Edward M Robertis

Edward M De Robertis

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Edward M Robertis

Edward M De Robertis

Publications by authors named "Edward M De Robertis"

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1PubMed Central Citations

Transcriptome analysis of regeneration during Xenopus laevis experimental twinning.

Int J Dev Biol 2019 ;63(6-7):301-309

Howard Hughes Medical Institute, Department of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.

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http://dx.doi.org/10.1387/ijdb.190006edDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7032064PMC
January 2020

Wnt canonical pathway activates macropinocytosis and lysosomal degradation of extracellular proteins.

Proc Natl Acad Sci U S A 2019 May 6;116(21):10402-10411. Epub 2019 May 6.

Howard Hughes Medical Institute, University of California, Los Angeles, CA 90095-1662;

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http://dx.doi.org/10.1073/pnas.1903506116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6534993PMC
May 2019

Canonical Wnt is inhibited by targeting one-carbon metabolism through methotrexate or methionine deprivation.

Proc Natl Acad Sci U S A 2019 02 24;116(8):2987-2995. Epub 2019 Jan 24.

Howard Hughes Medical Institute, University of California, Los Angeles, CA 90095-1662;

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http://dx.doi.org/10.1073/pnas.1820161116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6386671PMC
February 2019

Bighead is a Wnt antagonist secreted by the Spemann organizer that promotes Lrp6 endocytosis.

Proc Natl Acad Sci U S A 2018 09 12;115(39):E9135-E9144. Epub 2018 Sep 12.

Howard Hughes Medical Institute, University of California, Los Angeles, CA 90095-1662;

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http://dx.doi.org/10.1073/pnas.1812117115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6166843PMC
September 2018

Arginine methylation is required for canonical Wnt signaling and endolysosomal trafficking.

Proc Natl Acad Sci U S A 2018 06 17;115(23):E5317-E5325. Epub 2018 May 17.

Howard Hughes Medical Institute, University of California, Los Angeles, CA 90095;

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http://dx.doi.org/10.1073/pnas.1804091115DOI Listing
June 2018

Embryonic regeneration by relocalization of the Spemann organizer during twinning in .

Proc Natl Acad Sci U S A 2018 05 23;115(21):E4815-E4822. Epub 2018 Apr 23.

Howard Hughes Medical Institute, University of California, Los Angeles, CA 90095;

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http://dx.doi.org/10.1073/pnas.1802749115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6003488PMC
May 2018

Angiopoietin-like 4 Is a Wnt Signaling Antagonist that Promotes LRP6 Turnover.

Dev Cell 2017 10;43(1):71-82.e6

Division of Molecular Embryology, DKFZ-ZMBH Alliance, Deutsches Krebsforschungszentrum (DKFZ), 69120 Heidelberg, Germany; Institute of Molecular Biology (IMB), 55128 Mainz, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.devcel.2017.09.011DOI Listing
October 2017

Generation of animal form by the Chordin/Tolloid/BMP gradient: 100 years after D'Arcy Thompson.

Dev Growth Differ 2017 Sep 16;59(7):580-592. Epub 2017 Aug 16.

Howard Hughes Medical Institute and Department of Biological Chemistry, University of California, Los Angeles, Los Angeles, CA, 90095-1662, USA.

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http://dx.doi.org/10.1111/dgd.12388DOI Listing
September 2017

The Chordin Morphogenetic Pathway.

Curr Top Dev Biol 2016 7;116:231-45. Epub 2016 Jan 7.

Howard Hughes Medical Institute and Department of Biological Chemistry, University of California, Los Angeles, California, USA.

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http://dx.doi.org/10.1016/bs.ctdb.2015.10.003DOI Listing
August 2017

Genome-wide analysis of dorsal and ventral transcriptomes of the Xenopus laevis gastrula.

Dev Biol 2017 06 23;426(2):176-187. Epub 2016 Mar 23.

Howard Hughes Medical Institute and Department of Biological Chemistry, University of California, Los Angeles, CA 90095-1662, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ydbio.2016.02.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5033668PMC
June 2017

Spemann organizer transcriptome induction by early beta-catenin, Wnt, Nodal, and Siamois signals in .

Proc Natl Acad Sci U S A 2017 04 27;114(15):E3081-E3090. Epub 2017 Mar 27.

Howard Hughes Medical Institute, University of California, Los Angeles, CA 90095-1662;

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http://dx.doi.org/10.1073/pnas.1700766114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5393196PMC
April 2017

Smad4/DPC4: A barrier against tumor progression driven by RTK/Ras/Erk and Wnt/GSK3 signaling.

Mol Cell Oncol 2016 Mar 30;3(2):e989133. Epub 2015 Jan 30.

Howard Hughes Medical Institute and Department of Biological Chemistry; University of California ; Los Angeles, CA USA.

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http://dx.doi.org/10.4161/23723556.2014.989133DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905428PMC
March 2016

Point mutations in the tumor suppressor Smad4/DPC4 enhance its phosphorylation by GSK3 and reversibly inactivate TGF-β signaling.

Mol Cell Oncol 2016 Jan 14;3(1):e1025181. Epub 2015 Apr 14.

Howard Hughes Medical Institute and Department of Biological Chemistry; University of California ; Los Angeles, CA USA.

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http://dx.doi.org/10.1080/23723556.2015.1025181DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4845174PMC
January 2016

Sperm Motility Requires Wnt/GSK3 Stabilization of Proteins.

Dev Cell 2015 Nov;35(4):401-2

Howard Hughes Medical Institute and Department of Biological Chemistry, University of California, Los Angeles, Los Angeles, CA 90095-1737, USA.

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http://www.cell.com/developmental-cell/pdf/S1534-5807(15)007
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http://linkinghub.elsevier.com/retrieve/pii/S153458071500723
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http://dx.doi.org/10.1016/j.devcel.2015.11.009DOI Listing
November 2015

Morpholinos: Antisense and Sensibility.

Dev Cell 2015 Oct;35(2):145-9

Institute of Molecular Biology, 55128 Mainz, Germany; DKFZ-ZMBH Alliance, Division of Molecular Embryology, 69120 Heidelberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.devcel.2015.09.017DOI Listing
October 2015

The MITF family of transcription factors: Role in endolysosomal biogenesis, Wnt signaling, and oncogenesis.

Pharmacol Res 2015 Sep 21;99:36-43. Epub 2015 May 21.

Howard Hughes Medical Institute, University of California, Los Angeles, CA 90095-1662, United States; Department of Biological Chemistry, University of California, Los Angeles, CA 90095-1662, United States.

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http://dx.doi.org/10.1016/j.phrs.2015.04.006DOI Listing
September 2015

EMBRYO DEVELOPMENT. BMP gradients: A paradigm for morphogen-mediated developmental patterning.

Science 2015 Jun;348(6242):aaa5838

Howard Hughes Medical Institute, University of California, Los Angeles, Los Angeles, CA 90095-1662, USA. Department of Biological Chemistry, University of California, Los Angeles, Los Angeles, CA 90095-1662, USA.

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http://dx.doi.org/10.1126/science.aaa5838DOI Listing
June 2015

MITF drives endolysosomal biogenesis and potentiates Wnt signaling in melanoma cells.

Proc Natl Acad Sci U S A 2015 Feb 20;112(5):E420-9. Epub 2015 Jan 20.

Howard Hughes Medical Institute and Department of Biological Chemistry,

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http://dx.doi.org/10.1073/pnas.1424576112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4321275PMC
February 2015

The tumor suppressor Smad4/DPC4 is regulated by phosphorylations that integrate FGF, Wnt, and TGF-β signaling.

Cell Rep 2014 Oct 16;9(2):688-700. Epub 2014 Oct 16.

Howard Hughes Medical Institute and Department of Biological Chemistry, University of California, Los Angeles, Los Angeles, CA 90095-1662, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22111247140078
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http://dx.doi.org/10.1016/j.celrep.2014.09.020DOI Listing
October 2014

Yoshiki Sasai 1962–2014.

Dev Cell 2014 Sep;30(5):509-11

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http://dx.doi.org/10.1016/j.devcel.2014.08.022DOI Listing
September 2014

Yoshiki Sasai 1962-2014.

Cell 2014 Sep;158(6):1233-5

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http://dx.doi.org/10.1016/j.cell.2014.08.024DOI Listing
September 2014

Maternal syntabulin is required for dorsal axis formation and is a germ plasm component in Xenopus.

Differentiation 2014 Jul 3;88(1):17-26. Epub 2014 May 3.

Howard Hughes Medical Institute, Department of Biological Chemistry, University of California, Los Angeles, CA 90095-1662, United States. Electronic address:

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http://dx.doi.org/10.1016/j.diff.2014.03.002DOI Listing
July 2014

Lessons from a great developmental biologist.

Differentiation 2014 Jul 20;88(1):3-8. Epub 2014 Nov 20.

Howard Hughes Medical Institute and, Department of Biological Chemistry, University of California, Los Angeles, CA 90095-1662, United States. Electronic address:

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http://dx.doi.org/10.1016/j.diff.2013.12.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4286343PMC
July 2014

Chordin forms a self-organizing morphogen gradient in the extracellular space between ectoderm and mesoderm in the Xenopus embryo.

Proc Natl Acad Sci U S A 2013 Dec 27;110(51):20372-9. Epub 2013 Nov 27.

Howard Hughes Medical Institute and Department of Biological Chemistry, University of California, Los Angeles, CA 90095-1662.

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http://dx.doi.org/10.1073/pnas.1319745110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3870759PMC
December 2013

Development: scaling to size by protease inhibition.

Curr Biol 2013 Aug;23(15):R652-4

Howard Hughes Medical Institute and Department of Biological Chemistry, University of California Los Angeles, CA 90095-1662, USA.

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http://dx.doi.org/10.1016/j.cub.2013.06.055DOI Listing
August 2013

Presenilin deficiency or lysosomal inhibition enhances Wnt signaling through relocalization of GSK3 to the late-endosomal compartment.

Cell Rep 2012 Nov 1;2(5):1316-28. Epub 2012 Nov 1.

Howard Hughes Medical Institute and Department of Biological Chemistry, University of California, Los Angeles, CA 90095-1662, USA.

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http://dx.doi.org/10.1016/j.celrep.2012.09.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3538832PMC
November 2012

Systems control of BMP morphogen flow in vertebrate embryos.

Curr Opin Genet Dev 2011 Dec 19;21(6):696-703. Epub 2011 Sep 19.

Howard Hughes Medical Institute and Department of Biological Chemistry, University of California, Los Angeles, CA 90095-1662, USA.

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http://dx.doi.org/10.1016/j.gde.2011.09.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3224208PMC
December 2011

Endocytic control of growth factor signalling: multivesicular bodies as signalling organelles.

Nat Rev Mol Cell Biol 2011 11 23;13(1):53-60. Epub 2011 Nov 23.

Howard Hughes Medical Institute and Department of Biological Chemistry, University of California-Los Angeles, CA 90095-1662, USA.

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http://www.nature.com/articles/nrm3244
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http://dx.doi.org/10.1038/nrm3244DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3374592PMC
November 2011

Temporal pattern of the posterior expression of Wingless in Drosophila blastoderm.

Gene Expr Patterns 2011 Oct 28;11(7):456-63. Epub 2011 Jul 28.

Howard Hughes Medical Institute, Department of Biological Chemistry, University of California, Los Angeles, CA 90095-1662, United States.

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http://dx.doi.org/10.1016/j.gep.2011.07.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3200307PMC
October 2011

Phosphorylation of Mad controls competition between wingless and BMP signaling.

Sci Signal 2011 Oct 11;4(194):ra68. Epub 2011 Oct 11.

Howard Hughes Medical Institute and Department of Biological Chemistry, University of California, Los Angeles, CA 90095-1662, USA.

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http://dx.doi.org/10.1126/scisignal.2002034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3215398PMC
October 2011

Dorsal-ventral patterning: Crescent is a dorsally secreted Frizzled-related protein that competitively inhibits Tolloid proteases.

Dev Biol 2011 Apr 3;352(2):317-28. Epub 2011 Feb 3.

Department of Biological Chemistry, Howard Hughes Medical Institute, University of California, Los Angeles, CA 90095–1662, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S001216061100062
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http://dx.doi.org/10.1016/j.ydbio.2011.01.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3088358PMC
April 2011

Wnt signaling requires sequestration of glycogen synthase kinase 3 inside multivesicular endosomes.

Cell 2010 Dec;143(7):1136-48

Howard Hughes Medical Institute and Department of Biological Chemistry, University of California, Los Angeles, Los Angeles, CA 90095-1662, USA.

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http://dx.doi.org/10.1016/j.cell.2010.11.034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3022472PMC
December 2010

Wnt signaling in axial patterning and regeneration: lessons from planaria.

Sci Signal 2010 Jun 22;3(127):pe21. Epub 2010 Jun 22.

Howard Hughes Medical Institute and Department of Biological Chemistry, University of California, Los Angeles, Los Angeles, CA 90095-1662, USA.

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http://dx.doi.org/10.1126/scisignal.3127pe21DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3034647PMC
June 2010

Drosophila Smad2 opposes Mad signaling during wing vein development.

PLoS One 2010 Apr 28;5(4):e10383. Epub 2010 Apr 28.

Howard Hughes Medical Institute, Department of Biological Chemistry, University of California Los Angeles, Los Angeles, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0010383PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2860994PMC
April 2010

Enzymatic regulation of pattern: BMP4 binds CUB domains of Tolloids and inhibits proteinase activity.

Genes Dev 2009 Nov;23(21):2551-62

Howard Hughes Medical Institute and Department of Biological Chemistry, University of California at Los Angeles, Los Angeles, California 90095, USA.

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http://dx.doi.org/10.1101/gad.1839309DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2779747PMC
November 2009

Integrating patterning signals: Wnt/GSK3 regulates the duration of the BMP/Smad1 signal.

Cell 2007 Nov;131(5):980-93

Howard Hughes Medical Institute and Department of Biological Chemistry, University of California, Los Angeles, CA 90095-1662, USA.

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http://dx.doi.org/10.1016/j.cell.2007.09.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2200633PMC
November 2007

Spemann's organizer and self-regulation in amphibian embryos.

Nat Rev Mol Cell Biol 2006 Apr;7(4):296-302

Howard Hughes Medical Institute and Department of Biological Chemistry, University of California, Los Angeles, California 90095-1662, USA.

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http://dx.doi.org/10.1038/nrm1855DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2464568PMC
April 2006

Exploration of the extracellular space by a large-scale secretion screen in the early Xenopus embryo.

Int J Dev Biol 2005 ;49(7):781-96

Howard Hughes Medical Institute and Department of Biological Chemistry, University of California, Los Angeles, USA.

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http://dx.doi.org/10.1387/ijdb.052003epDOI Listing
January 2006

Depletion of Bmp2, Bmp4, Bmp7 and Spemann organizer signals induces massive brain formation in Xenopus embryos.

Development 2005 Aug 23;132(15):3381-92. Epub 2005 Jun 23.

Howard Hughes Medical Institute and Department of Biological Chemistry, University of California, Los Angeles, CA 90095-1662, USA.

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http://dev.biologists.org/cgi/doi/10.1242/dev.01901
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http://dx.doi.org/10.1242/dev.01901DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2278118PMC
August 2005

Dorsal-ventral patterning and neural induction in Xenopus embryos.

Annu Rev Cell Dev Biol 2004 ;20:285-308

Howard Hughes Medical Institute, Department of Biological Chemistry, University of California-Los Angeles, Los Angeles, CA 90095-1662, USA.

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http://dx.doi.org/10.1146/annurev.cellbio.20.011403.154124DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2280069PMC
February 2005

Identification of a second Xenopus twisted gastrulation gene.

Int J Dev Biol 2004 Feb;48(1):57-61

Howard Hughes Medical Institute, and Department of Biological Chemistry, University of California, Los Angeles, CA 90095-1662, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2311381PMC
http://dx.doi.org/10.1387/ijdb.15005575DOI Listing
February 2004