Edward Lakatta

Edward Lakatta

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Edward Lakatta

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Subclinical Longitudinal Change in Ankle-Brachial Index With Aging in a Community-Dwelling Population Is Associated With Central Arterial Stiffening.

J Am Heart Assoc 2019 Aug 5;8(15):e011650. Epub 2019 Aug 5.

Laboratory of Cardiovascular Science National Institute on Aging Baltimore MD.

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http://dx.doi.org/10.1161/JAHA.118.011650DOI Listing
August 2019

Complexities in Cardiovascular Rhythmicity - Perspectives on Circadian Normality, Aging and Disease.

Cardiovasc Res 2019 May 31. Epub 2019 May 31.

Laboratory of Cardiovascular Sciences, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.

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http://dx.doi.org/10.1093/cvr/cvz112DOI Listing
May 2019

Role of Adipokines in the Association between Thyroid Hormone and Components of the Metabolic Syndrome.

J Clin Med 2019 May 30;8(6). Epub 2019 May 30.

Istituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale delle Ricerche, c/o Cittadella Universitaria di Monserrato, 09042 Cagliari, Italy.

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http://dx.doi.org/10.3390/jcm8060764DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6617115PMC
May 2019

Acute salt loading and cardiotonic steroids in resistant hypertension.

Curr Top Membr 2019 18;83:1-13. Epub 2019 Feb 18.

National Institute on Aging, NIH, Baltimore, MD, United States; Sechenov Institute of Evolutionary Physiology and Biochemistry, St. Petersburg, Russia. Electronic address:

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http://dx.doi.org/10.1016/bs.ctm.2019.01.005DOI Listing
February 2019

Publisher Correction: Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits.

Authors:
Evangelos Evangelou Helen R Warren David Mosen-Ansorena Borbala Mifsud Raha Pazoki He Gao Georgios Ntritsos Niki Dimou Claudia P Cabrera Ibrahim Karaman Fu Liang Ng Marina Evangelou Katarzyna Witkowska Evan Tzanis Jacklyn N Hellwege Ayush Giri Digna R Velez Edwards Yan V Sun Kelly Cho J Michael Gaziano Peter W F Wilson Philip S Tsao Csaba P Kovesdy Tonu Esko Reedik Mägi Lili Milani Peter Almgren Thibaud Boutin Stéphanie Debette Jun Ding Franco Giulianini Elizabeth G Holliday Anne U Jackson Ruifang Li-Gao Wei-Yu Lin Jian'an Luan Massimo Mangino Christopher Oldmeadow Bram Peter Prins Yong Qian Muralidharan Sargurupremraj Nabi Shah Praveen Surendran Sébastien Thériault Niek Verweij Sara M Willems Jing-Hua Zhao Philippe Amouyel John Connell Renée de Mutsert Alex S F Doney Martin Farrall Cristina Menni Andrew D Morris Raymond Noordam Guillaume Paré Neil R Poulter Denis C Shields Alice Stanton Simon Thom Gonçalo Abecasis Najaf Amin Dan E Arking Kristin L Ayers Caterina M Barbieri Chiara Batini Joshua C Bis Tineka Blake Murielle Bochud Michael Boehnke Eric Boerwinkle Dorret I Boomsma Erwin P Bottinger Peter S Braund Marco Brumat Archie Campbell Harry Campbell Aravinda Chakravarti John C Chambers Ganesh Chauhan Marina Ciullo Massimiliano Cocca Francis Collins Heather J Cordell Gail Davies Martin H de Borst Eco J de Geus Ian J Deary Joris Deelen Fabiola Del Greco M Cumhur Yusuf Demirkale Marcus Dörr Georg B Ehret Roberto Elosua Stefan Enroth A Mesut Erzurumluoglu Teresa Ferreira Mattias Frånberg Oscar H Franco Ilaria Gandin Paolo Gasparini Vilmantas Giedraitis Christian Gieger Giorgia Girotto Anuj Goel Alan J Gow Vilmundur Gudnason Xiuqing Guo Ulf Gyllensten Anders Hamsten Tamara B Harris Sarah E Harris Catharina A Hartman Aki S Havulinna Andrew A Hicks Edith Hofer Albert Hofman Jouke-Jan Hottenga Jennifer E Huffman Shih-Jen Hwang Erik Ingelsson Alan James Rick Jansen Marjo-Riitta Jarvelin Roby Joehanes Åsa Johansson Andrew D Johnson Peter K Joshi Pekka Jousilahti J Wouter Jukema Antti Jula Mika Kähönen Sekar Kathiresan Bernard D Keavney Kay-Tee Khaw Paul Knekt Joanne Knight Ivana Kolcic Jaspal S Kooner Seppo Koskinen Kati Kristiansson Zoltan Kutalik Maris Laan Marty Larson Lenore J Launer Benjamin Lehne Terho Lehtimäki David C M Liewald Li Lin Lars Lind Cecilia M Lindgren YongMei Liu Ruth J F Loos Lorna M Lopez Yingchang Lu Leo-Pekka Lyytikäinen Anubha Mahajan Chrysovalanto Mamasoula Jaume Marrugat Jonathan Marten Yuri Milaneschi Anna Morgan Andrew P Morris Alanna C Morrison Peter J Munson Mike A Nalls Priyanka Nandakumar Christopher P Nelson Teemu Niiranen Ilja M Nolte Teresa Nutile Albertine J Oldehinkel Ben A Oostra Paul F O'Reilly Elin Org Sandosh Padmanabhan Walter Palmas Aarno Palotie Alison Pattie Brenda W J H Penninx Markus Perola Annette Peters Ozren Polasek Peter P Pramstaller Quang Tri Nguyen Olli T Raitakari Meixia Ren Rainer Rettig Kenneth Rice Paul M Ridker Janina S Ried Harriëtte Riese Samuli Ripatti Antonietta Robino Lynda M Rose Jerome I Rotter Igor Rudan Daniela Ruggiero Yasaman Saba Cinzia F Sala Veikko Salomaa Nilesh J Samani Antti-Pekka Sarin Reinhold Schmidt Helena Schmidt Nick Shrine David Siscovick Albert V Smith Harold Snieder Siim Sõber Rossella Sorice John M Starr David J Stott David P Strachan Rona J Strawbridge Johan Sundström Morris A Swertz Kent D Taylor Alexander Teumer Martin D Tobin Maciej Tomaszewski Daniela Toniolo Michela Traglia Stella Trompet Jaakko Tuomilehto Christophe Tzourio André G Uitterlinden Ahmad Vaez Peter J van der Most Cornelia M van Duijn Anne-Claire Vergnaud Germaine C Verwoert Veronique Vitart Uwe Völker Peter Vollenweider Dragana Vuckovic Hugh Watkins Sarah H Wild Gonneke Willemsen James F Wilson Alan F Wright Jie Yao Tatijana Zemunik Weihua Zhang John R Attia Adam S Butterworth Daniel I Chasman David Conen Francesco Cucca John Danesh Caroline Hayward Joanna M M Howson Markku Laakso Edward G Lakatta Claudia Langenberg Olle Melander Dennis O Mook-Kanamori Colin N A Palmer Lorenz Risch Robert A Scott Rodney J Scott Peter Sever Tim D Spector Pim van der Harst Nicholas J Wareham Eleftheria Zeggini Daniel Levy Patricia B Munroe Christopher Newton-Cheh Morris J Brown Andres Metspalu Adriana M Hung Christopher J O'Donnell Todd L Edwards Bruce M Psaty Ioanna Tzoulaki Michael R Barnes Louise V Wain Paul Elliott Mark J Caulfield

Nat Genet 2018 12;50(12):1755

William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.

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http://www.nature.com/articles/s41588-018-0297-3
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http://dx.doi.org/10.1038/s41588-018-0297-3DOI Listing
December 2018

Aging, MicroRNAs, and Heart Failure.

Curr Probl Cardiol 2018 Dec 29. Epub 2018 Dec 29.

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http://dx.doi.org/10.1016/j.cpcardiol.2018.12.003DOI Listing
December 2018

Adipocytokine correlations with thyroid function and autoimmunity in euthyroid sardinians.

Cytokine 2018 11 30;111:189-193. Epub 2018 Aug 30.

Istituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale delle Ricerche, c/o Cittadella Universitaria di Monserrato, Cagliari, Italy; Department of Biomedical Sciences, Azienda Ospedaliero-Universitaria di Sassari, Sassari, Italy.

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https://linkinghub.elsevier.com/retrieve/pii/S10434666183036
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http://dx.doi.org/10.1016/j.cyto.2018.08.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385598PMC
November 2018

Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits.

Authors:
Evangelos Evangelou Helen R Warren David Mosen-Ansorena Borbala Mifsud Raha Pazoki He Gao Georgios Ntritsos Niki Dimou Claudia P Cabrera Ibrahim Karaman Fu Liang Ng Marina Evangelou Katarzyna Witkowska Evan Tzanis Jacklyn N Hellwege Ayush Giri Digna R Velez Edwards Yan V Sun Kelly Cho J Michael Gaziano Peter W F Wilson Philip S Tsao Csaba P Kovesdy Tonu Esko Reedik Mägi Lili Milani Peter Almgren Thibaud Boutin Stéphanie Debette Jun Ding Franco Giulianini Elizabeth G Holliday Anne U Jackson Ruifang Li-Gao Wei-Yu Lin Jian'an Luan Massimo Mangino Christopher Oldmeadow Bram Peter Prins Yong Qian Muralidharan Sargurupremraj Nabi Shah Praveen Surendran Sébastien Thériault Niek Verweij Sara M Willems Jing-Hua Zhao Philippe Amouyel John Connell Renée de Mutsert Alex S F Doney Martin Farrall Cristina Menni Andrew D Morris Raymond Noordam Guillaume Paré Neil R Poulter Denis C Shields Alice Stanton Simon Thom Gonçalo Abecasis Najaf Amin Dan E Arking Kristin L Ayers Caterina M Barbieri Chiara Batini Joshua C Bis Tineka Blake Murielle Bochud Michael Boehnke Eric Boerwinkle Dorret I Boomsma Erwin P Bottinger Peter S Braund Marco Brumat Archie Campbell Harry Campbell Aravinda Chakravarti John C Chambers Ganesh Chauhan Marina Ciullo Massimiliano Cocca Francis Collins Heather J Cordell Gail Davies Martin H de Borst Eco J de Geus Ian J Deary Joris Deelen Fabiola Del Greco M Cumhur Yusuf Demirkale Marcus Dörr Georg B Ehret Roberto Elosua Stefan Enroth A Mesut Erzurumluoglu Teresa Ferreira Mattias Frånberg Oscar H Franco Ilaria Gandin Paolo Gasparini Vilmantas Giedraitis Christian Gieger Giorgia Girotto Anuj Goel Alan J Gow Vilmundur Gudnason Xiuqing Guo Ulf Gyllensten Anders Hamsten Tamara B Harris Sarah E Harris Catharina A Hartman Aki S Havulinna Andrew A Hicks Edith Hofer Albert Hofman Jouke-Jan Hottenga Jennifer E Huffman Shih-Jen Hwang Erik Ingelsson Alan James Rick Jansen Marjo-Riitta Jarvelin Roby Joehanes Åsa Johansson Andrew D Johnson Peter K Joshi Pekka Jousilahti J Wouter Jukema Antti Jula Mika Kähönen Sekar Kathiresan Bernard D Keavney Kay-Tee Khaw Paul Knekt Joanne Knight Ivana Kolcic Jaspal S Kooner Seppo Koskinen Kati Kristiansson Zoltan Kutalik Maris Laan Marty Larson Lenore J Launer Benjamin Lehne Terho Lehtimäki David C M Liewald Li Lin Lars Lind Cecilia M Lindgren YongMei Liu Ruth J F Loos Lorna M Lopez Yingchang Lu Leo-Pekka Lyytikäinen Anubha Mahajan Chrysovalanto Mamasoula Jaume Marrugat Jonathan Marten Yuri Milaneschi Anna Morgan Andrew P Morris Alanna C Morrison Peter J Munson Mike A Nalls Priyanka Nandakumar Christopher P Nelson Teemu Niiranen Ilja M Nolte Teresa Nutile Albertine J Oldehinkel Ben A Oostra Paul F O'Reilly Elin Org Sandosh Padmanabhan Walter Palmas Aarno Palotie Alison Pattie Brenda W J H Penninx Markus Perola Annette Peters Ozren Polasek Peter P Pramstaller Quang Tri Nguyen Olli T Raitakari Meixia Ren Rainer Rettig Kenneth Rice Paul M Ridker Janina S Ried Harriëtte Riese Samuli Ripatti Antonietta Robino Lynda M Rose Jerome I Rotter Igor Rudan Daniela Ruggiero Yasaman Saba Cinzia F Sala Veikko Salomaa Nilesh J Samani Antti-Pekka Sarin Reinhold Schmidt Helena Schmidt Nick Shrine David Siscovick Albert V Smith Harold Snieder Siim Sõber Rossella Sorice John M Starr David J Stott David P Strachan Rona J Strawbridge Johan Sundström Morris A Swertz Kent D Taylor Alexander Teumer Martin D Tobin Maciej Tomaszewski Daniela Toniolo Michela Traglia Stella Trompet Jaakko Tuomilehto Christophe Tzourio André G Uitterlinden Ahmad Vaez Peter J van der Most Cornelia M van Duijn Anne-Claire Vergnaud Germaine C Verwoert Veronique Vitart Uwe Völker Peter Vollenweider Dragana Vuckovic Hugh Watkins Sarah H Wild Gonneke Willemsen James F Wilson Alan F Wright Jie Yao Tatijana Zemunik Weihua Zhang John R Attia Adam S Butterworth Daniel I Chasman David Conen Francesco Cucca John Danesh Caroline Hayward Joanna M M Howson Markku Laakso Edward G Lakatta Claudia Langenberg Olle Melander Dennis O Mook-Kanamori Colin N A Palmer Lorenz Risch Robert A Scott Rodney J Scott Peter Sever Tim D Spector Pim van der Harst Nicholas J Wareham Eleftheria Zeggini Daniel Levy Patricia B Munroe Christopher Newton-Cheh Morris J Brown Andres Metspalu Adriana M Hung Christopher J O'Donnell Todd L Edwards Bruce M Psaty Ioanna Tzoulaki Michael R Barnes Louise V Wain Paul Elliott Mark J Caulfield

Nat Genet 2018 10 17;50(10):1412-1425. Epub 2018 Sep 17.

William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.

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http://dx.doi.org/10.1038/s41588-018-0205-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284793PMC
October 2018

Segment-specific associations between local haemodynamic and imaging markers of early atherosclerosis at the carotid artery: an human study.

J R Soc Interface 2018 Oct 10;15(147). Epub 2018 Oct 10.

Biomedical Simulation Lab, Department of Mechanical and Industrial Engineering, University of Toronto, Toronto, Ontario, Canada

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http://dx.doi.org/10.1098/rsif.2018.0352DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6228482PMC
October 2018

Dual Activation of Phosphodiesterases 3 and 4 Regulates Basal Spontaneous Beating Rate of Cardiac Pacemaker Cells: Role of Compartmentalization?

Front Physiol 2018 9;9:1301. Epub 2018 Oct 9.

Laboratory of Cardiovascular Science, Intramural Research Program, NIA, NIH, Baltimore, MD, United States.

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http://dx.doi.org/10.3389/fphys.2018.01301DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6189467PMC
October 2018

The reality of getting old.

Authors:
Edward G Lakatta

Nat Rev Cardiol 2018 Sep;15(9):499-500

Laboratory of Cardiovascular Science, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.

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http://dx.doi.org/10.1038/s41569-018-0068-yDOI Listing
September 2018

Heterogeneity of calcium clock functions in dormant, dysrhythmically and rhythmically firing single pacemaker cells isolated from SA node.

Cell Calcium 2018 09 10;74:168-179. Epub 2018 Jul 10.

Laboratory of Cardiovascular Science, National Institute on Aging, NIH, Biomedical Research Center, 251 Bayview Blvd. Suite 100, Baltimore, MD 21224-6825, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ceca.2018.07.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402562PMC
September 2018

Unique Ca-Cycling Protein Abundance and Regulation Sustains Local Ca Releases and Spontaneous Firing of Rabbit Sinoatrial Node Cells.

Int J Mol Sci 2018 Jul 25;19(8). Epub 2018 Jul 25.

Laboratory of Cardiovascular Science, Intramural Research Program, National Institute on Aging, NIH, 251 Bayview Blvd, Room 8B-123, Baltimore, MD 21224, USA.

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http://dx.doi.org/10.3390/ijms19082173DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6121616PMC
July 2018

PR interval genome-wide association meta-analysis identifies 50 loci associated with atrial and atrioventricular electrical activity.

Authors:
Jessica van Setten Jennifer A Brody Yalda Jamshidi Brenton R Swenson Anne M Butler Harry Campbell Fabiola M Del Greco Daniel S Evans Quince Gibson Daniel F Gudbjartsson Kathleen F Kerr Bouwe P Krijthe Leo-Pekka Lyytikäinen Christian Müller Martina Müller-Nurasyid Ilja M Nolte Sandosh Padmanabhan Marylyn D Ritchie Antonietta Robino Albert V Smith Maristella Steri Toshiko Tanaka Alexander Teumer Stella Trompet Sheila Ulivi Niek Verweij Xiaoyan Yin David O Arnar Folkert W Asselbergs Joel S Bader John Barnard Josh Bis Stefan Blankenberg Eric Boerwinkle Yuki Bradford Brendan M Buckley Mina K Chung Dana Crawford Marcel den Hoed Josh C Denny Anna F Dominiczak Georg B Ehret Mark Eijgelsheim Patrick T Ellinor Stephan B Felix Oscar H Franco Lude Franke Tamara B Harris Hilma Holm Gandin Ilaria Annamaria Iorio Mika Kähönen Ivana Kolcic Jan A Kors Edward G Lakatta Lenore J Launer Honghuang Lin Henry J Lin Ruth J F Loos Steven A Lubitz Peter W Macfarlane Jared W Magnani Irene Mateo Leach Thomas Meitinger Braxton D Mitchell Thomas Munzel George J Papanicolaou Annette Peters Arne Pfeufer Peter P Pramstaller Olli T Raitakari Jerome I Rotter Igor Rudan Nilesh J Samani David Schlessinger Claudia T Silva Aldana Moritz F Sinner Jonathan D Smith Harold Snieder Elsayed Z Soliman Timothy D Spector David J Stott Konstantin Strauch Kirill V Tarasov Unnur Thorsteinsdottir Andre G Uitterlinden David R Van Wagoner Uwe Völker Henry Völzke Melanie Waldenberger Harm Jan Westra Philipp S Wild Tanja Zeller Alvaro Alonso Christy L Avery Stefania Bandinelli Emelia J Benjamin Francesco Cucca Marcus Dörr Luigi Ferrucci Paolo Gasparini Vilmundur Gudnason Caroline Hayward Susan R Heckbert Andrew A Hicks J Wouter Jukema Stefan Kääb Terho Lehtimäki Yongmei Liu Patricia B Munroe Afshin Parsa Ozren Polasek Bruce M Psaty Dan M Roden Renate B Schnabel Gianfranco Sinagra Kari Stefansson Bruno H Stricker Pim van der Harst Cornelia M van Duijn James F Wilson Sina A Gharib Paul I W de Bakker Aaron Isaacs Dan E Arking Nona Sotoodehnia

Nat Commun 2018 07 25;9(1):2904. Epub 2018 Jul 25.

Departments of Medicine and Epidemiology, Cardiovascular Health Research Unit, Division of Cardiology, University of Washington, Seattle, 98101, WA, USA.

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http://dx.doi.org/10.1038/s41467-018-04766-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6060178PMC
July 2018

Basal Spontaneous Firing of Rabbit Sinoatrial Node Cells Is Regulated by Dual Activation of PDEs (Phosphodiesterases) 3 and 4.

Circ Arrhythm Electrophysiol 2018 06;11(6):e005896

Laboratory of Cardiovascular Science, Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, MD.

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http://dx.doi.org/10.1161/CIRCEP.117.005896DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6025775PMC
June 2018

Reduced vasorin enhances angiotensin II signaling within the aging arterial wall.

Oncotarget 2018 Jun 5;9(43):27117-27132. Epub 2018 Jun 5.

Laboratory of Cardiovascular Science, National Institute on Aging, National Institutes of Health, Biomedical Research Center (BRC), Baltimore, MD, USA.

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http://www.oncotarget.com/fulltext/25499
Publisher Site
http://dx.doi.org/10.18632/oncotarget.25499DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6007470PMC
June 2018

Electrophysiological heterogeneity of pacemaker cells in the rabbit intercaval region, including the SA node: insights from recording multiple ion currents in each cell.

Am J Physiol Heart Circ Physiol 2018 03 15;314(3):H403-H414. Epub 2017 Sep 15.

Laboratory of Cardiovascular Science, Biomedical Research Center, National Institute on Aging, National Institutes of Health , Baltimore, Maryland.

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http://dx.doi.org/10.1152/ajpheart.00253.2016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5899256PMC
March 2018

Positive Feedback Mechanisms among Local Ca Releases, NCX, and I Ignite Pacemaker Action Potentials.

Biophys J 2018 03;114(5):1176-1189

Laboratory of Cardiovascular Science, Biomedical Research Center, Intramural Research Program, National Institute on Aging, NIH, Baltimore, Maryland. Electronic address:

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http://dx.doi.org/10.1016/j.bpj.2017.12.043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5883559PMC
March 2018

TGFβ1 reinforces arterial aging in the vascular smooth muscle cell through a long-range regulation of the cytoskeletal stiffness.

Sci Rep 2018 02 8;8(1):2668. Epub 2018 Feb 8.

Department of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, 21205, USA.

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http://dx.doi.org/10.1038/s41598-018-20763-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5805716PMC
February 2018

Spontaneous, local diastolic subsarcolemmal calcium releases in single, isolated guinea-pig sinoatrial nodal cells.

PLoS One 2017 25;12(9):e0185222. Epub 2017 Sep 25.

Laboratory of Cardiovascular Science, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0185222PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5612473PMC
October 2017

Long-term low dose dietary resveratrol supplement reduces cardiovascular structural and functional deterioration in chronic heart failure in rats.

Can J Physiol Pharmacol 2017 Mar 17;95(3):268-274. Epub 2016 Dec 17.

Laboratory of Cardiovascular Sciences, Intramural Research Program, NIA, NIH, Baltimore, MD 21224, USA.

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http://dx.doi.org/10.1139/cjpp-2016-0512DOI Listing
March 2017

Arterial Stiffness and Risk of Overall Heart Failure, Heart Failure With Preserved Ejection Fraction, and Heart Failure With Reduced Ejection Fraction: The Health ABC Study (Health, Aging, and Body Composition).

Hypertension 2017 02 19;69(2):267-274. Epub 2016 Dec 19.

From the Division of Cardiology, Department of Internal Medicine (A.P., J.D.B.) and Department of Clinical Sciences (J.D.B.), University of Texas Southwestern Medical Center, Dallas; Department of Internal Medicine, Emory University School of Medicine, Atlanta, GA (H.K.); Department of Epidemiology, Graduate School of Public Health at University of Pittsburgh, PA (A.B.N.); Laboratory of Cardiovascular Science, Biomedical Research Center, National Institutes of Heath, National Institute of Aging, Baltimore, MD (E.G.L.); Section of Geriatric Cardiology, Divisions of Geriatrics and Cardiology, University of Pittsburgh School of Medicine, VA Pittsburgh Healthcare System, PA (D.E.F.); and Division of Cardiology, Department of Internal Medicine, Stony Brook University School of Medicine, New York, NY (J.B.).

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.116.08327DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5828168PMC
February 2017

The Pressure of Aging.

Med Clin North Am 2017 Jan;101(1):81-101

Laboratory of Cardiovascular Science, NIA, NIH, Baltimore, MD, USA. Electronic address:

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http://dx.doi.org/10.1016/j.mcna.2016.08.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5206899PMC
January 2017

The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals.

Authors:
Georg B Ehret Teresa Ferreira Daniel I Chasman Anne U Jackson Ellen M Schmidt Toby Johnson Gudmar Thorleifsson Jian'an Luan Lousie A Donnelly Stavroula Kanoni Ann-Kristin Petersen Vasyl Pihur Rona J Strawbridge Dmitry Shungin Maria F Hughes Osorio Meirelles Marika Kaakinen Nabila Bouatia-Naji Kati Kristiansson Sonia Shah Marcus E Kleber Xiuqing Guo Leo-Pekka Lyytikäinen Cristiano Fava Niclas Eriksson Ilja M Nolte Patrik K Magnusson Elias L Salfati Loukianos S Rallidis Elizabeth Theusch Andrew J P Smith Lasse Folkersen Kate Witkowska Tune H Pers Roby Joehanes Stuart K Kim Lazaros Lataniotis Rick Jansen Andrew D Johnson Helen Warren Young Jin Kim Wei Zhao Ying Wu Bamidele O Tayo Murielle Bochud Devin Absher Linda S Adair Najaf Amin Dan E Arking Tomas Axelsson Damiano Baldassarre Beverley Balkau Stefania Bandinelli Michael R Barnes Inês Barroso Stephen Bevan Joshua C Bis Gyda Bjornsdottir Michael Boehnke Eric Boerwinkle Lori L Bonnycastle Dorret I Boomsma Stefan R Bornstein Morris J Brown Michel Burnier Claudia P Cabrera John C Chambers I-Shou Chang Ching-Yu Cheng Peter S Chines Ren-Hua Chung Francis S Collins John M Connell Angela Döring Jean Dallongeville John Danesh Ulf de Faire Graciela Delgado Anna F Dominiczak Alex S F Doney Fotios Drenos Sarah Edkins John D Eicher Roberto Elosua Stefan Enroth Jeanette Erdmann Per Eriksson Tonu Esko Evangelos Evangelou Alun Evans Tove Fall Martin Farrall Janine F Felix Jean Ferrières Luigi Ferrucci Myriam Fornage Terrence Forrester Nora Franceschini Oscar H Franco Duran Anders Franco-Cereceda Ross M Fraser Santhi K Ganesh He Gao Karl Gertow Francesco Gianfagna Bruna Gigante Franco Giulianini Anuj Goel Alison H Goodall Mark O Goodarzi Mathias Gorski Jürgen Gräßler Christopher Groves Vilmundur Gudnason Ulf Gyllensten Göran Hallmans Anna-Liisa Hartikainen Maija Hassinen Aki S Havulinna Caroline Hayward Serge Hercberg Karl-Heinz Herzig Andrew A Hicks Aroon D Hingorani Joel N Hirschhorn Albert Hofman Jostein Holmen Oddgeir Lingaas Holmen Jouke-Jan Hottenga Phil Howard Chao A Hsiung Steven C Hunt M Arfan Ikram Thomas Illig Carlos Iribarren Richard A Jensen Mika Kähönen Hyun Kang Sekar Kathiresan Brendan J Keating Kay-Tee Khaw Yun Kyoung Kim Eric Kim Mika Kivimaki Norman Klopp Genovefa Kolovou Pirjo Komulainen Jaspal S Kooner Gulum Kosova Ronald M Krauss Diana Kuh Zoltan Kutalik Johanna Kuusisto Kirsti Kvaløy Timo A Lakka Nanette R Lee I-Te Lee Wen-Jane Lee Daniel Levy Xiaohui Li Kae-Woei Liang Honghuang Lin Li Lin Jaana Lindström Stéphane Lobbens Satu Männistö Gabriele Müller Martina Müller-Nurasyid François Mach Hugh S Markus Eirini Marouli Mark I McCarthy Colin A McKenzie Pierre Meneton Cristina Menni Andres Metspalu Vladan Mijatovic Leena Moilanen May E Montasser Andrew D Morris Alanna C Morrison Antonella Mulas Ramaiah Nagaraja Narisu Narisu Kjell Nikus Christopher J O'Donnell Paul F O'Reilly Ken K Ong Fred Paccaud Cameron D Palmer Afshin Parsa Nancy L Pedersen Brenda W Penninx Markus Perola Annette Peters Neil Poulter Peter P Pramstaller Bruce M Psaty Thomas Quertermous Dabeeru C Rao Asif Rasheed N William N W R Rayner Frida Renström Rainer Rettig Kenneth M Rice Robert Roberts Lynda M Rose Jacques Rossouw Nilesh J Samani Serena Sanna Jouko Saramies Heribert Schunkert Sylvain Sebert Wayne H-H Sheu Young-Ah Shin Xueling Sim Johannes H Smit Albert V Smith Maria X Sosa Tim D Spector Alena Stančáková Alice Stanton Kathleen E Stirrups Heather M Stringham Johan Sundstrom Amy J Swift Ann-Christine Syvänen E-Shyong Tai Toshiko Tanaka Kirill V Tarasov Alexander Teumer Unnur Thorsteinsdottir Martin D Tobin Elena Tremoli Andre G Uitterlinden Matti Uusitupa Ahmad Vaez Dhananjay Vaidya Cornelia M van Duijn Erik P A van Iperen Ramachandran S Vasan Germaine C Verwoert Jarmo Virtamo Veronique Vitart Benjamin F Voight Peter Vollenweider Aline Wagner Louise V Wain Nicholas J Wareham Hugh Watkins Alan B Weder Harm-Jan Westra Rainford Wilks Tom Wilsgaard James F Wilson Tien Y Wong Tsun-Po Yang Jie Yao Loic Yengo Weihua Zhang Jing Hua Zhao Xiaofeng Zhu Pascal Bovet Richard S Cooper Karen L Mohlke Danish Saleheen Jong-Young Lee Paul Elliott Hinco J Gierman Cristen J Willer Lude Franke G Kees Hovingh Kent D Taylor George Dedoussis Peter Sever Andrew Wong Lars Lind Themistocles L Assimes Inger Njølstad Peter Eh Schwarz Claudia Langenberg Harold Snieder Mark J Caulfield Olle Melander Markku Laakso Juha Saltevo Rainer Rauramaa Jaakko Tuomilehto Erik Ingelsson Terho Lehtimäki Kristian Hveem Walter Palmas Winfried März Meena Kumari Veikko Salomaa Yii-Der I Chen Jerome I Rotter Philippe Froguel Marjo-Riitta Jarvelin Edward G Lakatta Kari Kuulasmaa Paul W Franks Anders Hamsten H-Erich Wichmann Colin N A Palmer Kari Stefansson Paul M Ridker Ruth J F Loos Aravinda Chakravarti Panos Deloukas Andrew P Morris Christopher Newton-Cheh Patricia B Munroe

Nat Genet 2016 10 12;48(10):1171-1184. Epub 2016 Sep 12.

Clinical Pharmacology, William Harvey Research Institute, Queen Mary University of London, London, EC1M 6BQ, UK.

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http://dx.doi.org/10.1038/ng.3667DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5042863PMC
October 2016

CaMKII-dependent phosphorylation regulates basal cardiac pacemaker function via modulation of local Ca2+ releases.

Am J Physiol Heart Circ Physiol 2016 09 8;311(3):H532-44. Epub 2016 Jul 8.

Laboratory of Cardiovascular Science, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, Maryland

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http://dx.doi.org/10.1152/ajpheart.00765.2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5142178PMC
September 2016

Mouse RAGE Variant 4 Is a Dominant Membrane Receptor that Does Not Shed to Generate Soluble RAGE.

PLoS One 2016;11(9):e0153657. Epub 2016 Sep 21.

Laboratory of Cardiovascular Sciences, National Institute on Aging, NIH, Baltimore, Maryland, United States of America.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5031407PMC
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0153657PLOS
September 2016

52 Genetic Loci Influencing Myocardial Mass.

Authors:
Pim van der Harst Jessica van Setten Niek Verweij Georg Vogler Lude Franke Matthew T Maurano Xinchen Wang Irene Mateo Leach Mark Eijgelsheim Nona Sotoodehnia Caroline Hayward Rossella Sorice Osorio Meirelles Leo-Pekka Lyytikäinen Ozren Polašek Toshiko Tanaka Dan E Arking Sheila Ulivi Stella Trompet Martina Müller-Nurasyid Albert V Smith Marcus Dörr Kathleen F Kerr Jared W Magnani Fabiola Del Greco M Weihua Zhang Ilja M Nolte Claudia T Silva Sandosh Padmanabhan Vinicius Tragante Tõnu Esko Gonçalo R Abecasis Michiel E Adriaens Karl Andersen Phil Barnett Joshua C Bis Rolf Bodmer Brendan M Buckley Harry Campbell Megan V Cannon Aravinda Chakravarti Lin Y Chen Alessandro Delitala Richard B Devereux Pieter A Doevendans Anna F Dominiczak Luigi Ferrucci Ian Ford Christian Gieger Tamara B Harris Eric Haugen Matthias Heinig Dena G Hernandez Hans L Hillege Joel N Hirschhorn Albert Hofman Norbert Hubner Shih-Jen Hwang Annamaria Iorio Mika Kähönen Manolis Kellis Ivana Kolcic Ishminder K Kooner Jaspal S Kooner Jan A Kors Edward G Lakatta Kasper Lage Lenore J Launer Daniel Levy Alicia Lundby Peter W Macfarlane Dalit May Thomas Meitinger Andres Metspalu Stefania Nappo Silvia Naitza Shane Neph Alex S Nord Teresa Nutile Peter M Okin Jesper V Olsen Ben A Oostra Josef M Penninger Len A Pennacchio Tune H Pers Siegfried Perz Annette Peters Yigal M Pinto Arne Pfeufer Maria Grazia Pilia Peter P Pramstaller Bram P Prins Olli T Raitakari Soumya Raychaudhuri Ken M Rice Elizabeth J Rossin Jerome I Rotter Sebastian Schafer David Schlessinger Carsten O Schmidt Jobanpreet Sehmi Herman H W Silljé Gianfranco Sinagra Moritz F Sinner Kamil Slowikowski Elsayed Z Soliman Timothy D Spector Wilko Spiering John A Stamatoyannopoulos Ronald P Stolk Konstantin Strauch Sian-Tsung Tan Kirill V Tarasov Bosco Trinh Andre G Uitterlinden Malou van den Boogaard Cornelia M van Duijn Wiek H van Gilst Jorma S Viikari Peter M Visscher Veronique Vitart Uwe Völker Melanie Waldenberger Christian X Weichenberger Harm-Jan Westra Cisca Wijmenga Bruce H Wolffenbuttel Jian Yang Connie R Bezzina Patricia B Munroe Harold Snieder Alan F Wright Igor Rudan Laurie A Boyer Folkert W Asselbergs Dirk J van Veldhuisen Bruno H Stricker Bruce M Psaty Marina Ciullo Serena Sanna Terho Lehtimäki James F Wilson Stefania Bandinelli Alvaro Alonso Paolo Gasparini J Wouter Jukema Stefan Kääb Vilmundur Gudnason Stephan B Felix Susan R Heckbert Rudolf A de Boer Christopher Newton-Cheh Andrew A Hicks John C Chambers Yalda Jamshidi Axel Visel Vincent M Christoffels Aaron Isaacs Nilesh J Samani Paul I W de Bakker

J Am Coll Cardiol 2016 09;68(13):1435-1448

Department of Medical Genetics, University Medical Center Utrecht, Utrecht, the Netherlands; Department of Epidemiology, University Medical Center Utrecht, Utrecht, the Netherlands.

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http://dx.doi.org/10.1016/j.jacc.2016.07.729DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5478167PMC
September 2016

A Rat Carotid Balloon Injury Model to Test Anti-vascular Remodeling Therapeutics.

J Vis Exp 2016 09 19(115). Epub 2016 Sep 19.

Laboratory of Cardiovascular Sciences, National Institute on Aging;

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http://dx.doi.org/10.3791/53777DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5092041PMC
September 2016

Deterioration of autonomic neuronal receptor signaling and mechanisms intrinsic to heart pacemaker cells contribute to age-associated alterations in heart rate variability in vivo.

Aging Cell 2016 08 10;15(4):716-24. Epub 2016 May 10.

Laboratory of Cardiovascular Science, Biomedical Research Center, Intramural Research Program, National Institute on Aging, NIH, Baltimore, MD, USA.

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http://dx.doi.org/10.1111/acel.12483DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4933656PMC
August 2016

Prognostic significance of mechanical biomarkers derived from pulse wave analysis for predicting long-term cardiovascular mortality in two population-based cohorts.

Int J Cardiol 2016 Jul 17;215:388-95. Epub 2016 Apr 17.

Department of Medical Education, Taipei Veterans General Hospital, Taipei, Taiwan; Cardiovascular Research Center, National Yang-Ming University, Taipei, Taiwan; Faculty of Medicine, National Yang-Ming University, Taipei, Taiwan; Department of Public Health, National Yang-Ming University, Taipei, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.ijcard.2016.04.070DOI Listing
July 2016

Electrochemical Na+ and Ca2+ gradients drive coupled-clock regulation of automaticity of isolated rabbit sinoatrial nodal pacemaker cells.

Am J Physiol Heart Circ Physiol 2016 07 20;311(1):H251-67. Epub 2016 May 20.

Laboratory of Cardiovascular Science, National Institutes of Health, National Institute on Aging, Intramural Research Program, Baltimore, Maryland;

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http://dx.doi.org/10.1152/ajpheart.00667.2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4967203PMC
July 2016

Pharmacological Strategies to Retard Cardiovascular Aging.

Circ Res 2016 05;118(10):1626-42

From the Experimental Gerontology Section, Translational Gerontology Branch (I.A., C.D.G., M.B., R.d.C.) and Laboratory of Cardiovascular Science (E.G.L.), National Institute on Aging, National Institutes of Health, Baltimore, MD; Faculty of Veterinary Medicine, University of Teramo, Teramo, Italy (C.D.G.); and Reynolds Oklahoma Center on Aging, Department of Geriatric Medicine, University of Oklahoma Health Science Center, Oklahoma City, OK (A.C., Z.U.).

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http://dx.doi.org/10.1161/CIRCRESAHA.116.307475DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4894351PMC
May 2016

AGE-RAGE signal generates a specific NF-κB RelA "barcode" that directs collagen I expression.

Sci Rep 2016 Jan 5;6:18822. Epub 2016 Jan 5.

Laboratory of Cardiovascular Sciences, National Institute on Aging, National Institute of Health, Baltimore, MD 21224.

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http://dx.doi.org/10.1038/srep18822DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4700418PMC
January 2016

The end effector of circadian heart rate variation: the sinoatrial node pacemaker cell.

BMB Rep 2015 Dec;48(12):677-84

Laboratory of Cardiovascular Science, Biomedical Research Center, Intramural Research Program, National Institute on Aging, NIH, Baltimore, Maryland, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4791323PMC
http://dx.doi.org/10.5483/bmbrep.2015.48.12.061DOI Listing
December 2015

Real-time relationship between PKA biochemical signal network dynamics and increased action potential firing rate in heart pacemaker cells: Kinetics of PKA activation in heart pacemaker cells.

J Mol Cell Cardiol 2015 Sep 1;86:168-78. Epub 2015 Aug 1.

Laboratory of Cardiovascular Science, Biomedical Research Center Intramural Research Program, National Institute on Aging, NIH, Baltimore, MD, USA. Electronic address:

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http://dx.doi.org/10.1016/j.yjmcc.2015.07.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4558217PMC
September 2015

Marinobufagenin-induced vascular fibrosis is a likely target for mineralocorticoid antagonists.

J Hypertens 2015 Aug;33(8):1602-10

aNational Institute on Aging, NIH, Baltimore, Maryland, USA bInstitute of Heart and Vessels, Almazov Federal Heart, Blood and Endocrinology Centre, St. Petersburg, Russia cDepartment of Biotechnology, Technion Institute, Haifa, Israel dSechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg, Russia.

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http://dx.doi.org/10.1097/HJH.0000000000000591DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4547457PMC
August 2015

Proinflammation of aging central arteries: a mini-review.

Gerontology 2014 28;60(6):519-29. Epub 2014 Aug 28.

Laboratory of Cardiovascular Science, National Institute on Aging, National Institutes of Health, Biomedical Research Center (BRC), Baltimore, Md., USA.

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http://dx.doi.org/10.1159/000362548DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4209183PMC
June 2015

So! What's aging? Is cardiovascular aging a disease?

Authors:
Edward G Lakatta

J Mol Cell Cardiol 2015 Jun 11;83:1-13. Epub 2015 Apr 11.

Laboratory of Cardiovascular Science, Intramural Research Program, National Institute on Aging, Biomedical Research Center, NIH, 251 Bayview Blvd., Baltimore, MD 21224, USA. Electronic address:

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http://dx.doi.org/10.1016/j.yjmcc.2015.04.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4532266PMC
June 2015

Vinculin network-mediated cytoskeletal remodeling regulates contractile function in the aging heart.

Sci Transl Med 2015 Jun;7(292):292ra99

Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093, USA. Biomedical Sciences Program, University of California, San Diego, La Jolla, CA 92093, USA. Sanford Consortium for Regenerative Medicine, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1126/scitranslmed.aaa5843DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4507505PMC
June 2015

Matrix metalloproteinases promote arterial remodeling in aging, hypertension, and atherosclerosis.

Hypertension 2015 Apr 9;65(4):698-703. Epub 2015 Feb 9.

From the Laboratory of Cardiovascular Science, National Institute on Aging, National Institutes of Health, Biomedical Research Center (BRC), Baltimore, MD.

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.114.03618DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4359070PMC
April 2015

Plasma level of the endogenous sodium pump ligand marinobufagenin is related to the salt-sensitivity in men.

J Hypertens 2015 Mar;33(3):534-41; discussion 541

aLaboratory of Cardiovascular Science, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA bDepartment of Clinical Sciences, Lund University cDepartment of Internal Medicine, Skåne University Hospital, Malmö, Sweden.

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http://dx.doi.org/10.1097/HJH.0000000000000437DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4543292PMC
March 2015

From two competing oscillators to one coupled-clock pacemaker cell system.

Front Physiol 2015 13;6:28. Epub 2015 Feb 13.

Laboratory of Cardiovascular Science, Biomedical Research Center, Intramural Research Program, National Institute on Aging, National Institutes of Health Baltimore, MD, USA.

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http://dx.doi.org/10.3389/fphys.2015.00028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4327306PMC
March 2015

Potential effects of intrinsic heart pacemaker cell mechanisms on dysrhythmic cardiac action potential firing.

Front Physiol 2015 23;6:47. Epub 2015 Feb 23.

Laboratory of Cardiovascular Science, Biomedical Research Center, Intramural Research Program, National Institute on Aging, National Institutes of Health Baltimore, MD, USA.

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http://dx.doi.org/10.3389/fphys.2015.00047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4337365PMC
March 2015

Serum from calorie-restricted animals delays senescence and extends the lifespan of normal human fibroblasts in vitro.

Aging (Albany NY) 2015 Mar;7(3):152-66

Experimental Gerontology Section, Translational Gerontology Branch, NIA/NIH, Baltimore, MD 21224, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4394727PMC
http://dx.doi.org/10.18632/aging.100719DOI Listing
March 2015

The conundrum of arterial stiffness, elevated blood pressure, and aging.

Curr Hypertens Rep 2015 Feb;17(2):12

Laboratory of Cardiovascular Science, NIA, NIH, Baltimore, MD, USA,

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http://dx.doi.org/10.1007/s11906-014-0523-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4524667PMC
February 2015

Biophysical characterization of the underappreciated and important relationship between heart rate variability and heart rate.

Hypertension 2014 Dec 15;64(6):1334-43. Epub 2014 Sep 15.

From the Institute of Cardiovascular Sciences, University of Manchester, Manchester, United Kingdom (O.M., H.S., M.N., M.R.B.); Laboratory of Cardiovascular Science, National Institute on Aging-Intramural Research Program, National Institutes of Health, Baltimore, MD (O.M., A.E.L., V.A.M., E.G.L.); K.G. Jebsen Center of Exercise in Medicine at Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway (A.-B.J., U.W.); Laboratory of Biomedical Sciences and Information Management, National Cerebral and Cardiovascular Center, Osaka, Japan (S.I.); and Biological Physics Group, University of Manchester, Manchester, United Kingdom (R.W., H.Z.).

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.114.03782DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4326239PMC
December 2014

Longitudinal perspective on the conundrum of central arterial stiffness, blood pressure, and aging.

Hypertension 2014 Dec 15;64(6):1219-27. Epub 2014 Sep 15.

From the Hospital San Raffaele Pisana-Istituto Ricovero e Cura a Carattere Sceintifico (IRCCS), Rome, Italy (A.S.); Laboratory of Cardiovascular Science, National Institute of Aging, Baltimore, MD (C.H.M., J.B.S., K.V.T., H.S., E.G.L.); Loyola University Maryland, Baltimore (C.H.M.); Istituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale delle Ricerche, c/o Cittadella Universitaria di Monserrato, Monserrato, Cagliari, Italy (M.O., L.A.P.F., F.L., M.G.P., A.D.); Johns Hopkins School of Medicine, Baltimore, MD (M.A.); and MedStar Heart Institute, Washington, DC (S.S.N.).

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.114.04127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4231012PMC
December 2014

Stochasticity intrinsic to coupled-clock mechanisms underlies beat-to-beat variability of spontaneous action potential firing in sinoatrial node pacemaker cells.

J Mol Cell Cardiol 2014 Dec 22;77:1-10. Epub 2014 Sep 22.

Laboratory of Cardiovascular Science, Biomedical Research Center, Intramural Research Program, National Institute on Aging, NIH, Baltimore, MD, USA. Electronic address:

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http://dx.doi.org/10.1016/j.yjmcc.2014.09.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4312254PMC
December 2014

Vessel ultrasound sonographic assessment of soluble receptor for advanced glycation end products efficacy in a rat balloon injury model.

Curr Ther Res Clin Exp 2014 Dec 11;76:110-5. Epub 2014 Nov 11.

Laboratory of Cardiovascular Science, National Institute on Aging, National Institutes of Health, Baltimore, Maryland.

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http://dx.doi.org/10.1016/j.curtheres.2014.08.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4229510PMC
December 2014

Modern perspectives on numerical modeling of cardiac pacemaker cell.

J Pharmacol Sci 2014 19;125(1):6-38. Epub 2014 Apr 19.

Laboratory of Cardiovascular Science, Intramural Research Program, National Institute on Aging, NIH, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4530975PMC
October 2014

Are personality traits associated with white-coat and masked hypertension?

J Hypertens 2014 Oct;32(10):1987-92; discussion 1992

aFlorida State University College of Medicine, Tallahassee, Florida bNational Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA cHospital San Raffaele Pisana IRCCS, Rome dIstituto di Neurogenetica e Neurofarmacologia, Consiglio Nazionale delle Ricerche eUnità Operativa Complessa Cardiologia, Presidio Ospedaliero A. Businco, Cagliari, Italy.

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http://dx.doi.org/10.1097/HJH.0000000000000289DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4196211PMC
October 2014

Impact of central obesity on the estimation of carotid-femoral pulse wave velocity.

Am J Hypertens 2014 Sep 17;27(9):1209-17. Epub 2014 Mar 17.

Longitudinal Studies Section, Translational Gerontology Branch, National Institute of Aging, National Institutes of Health, Baltimore, Maryland;

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http://dx.doi.org/10.1093/ajh/hpu038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4141203PMC
September 2014

Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization.

Authors:
Dan E Arking Sara L Pulit Lia Crotti Pim van der Harst Patricia B Munroe Tamara T Koopmann Nona Sotoodehnia Elizabeth J Rossin Michael Morley Xinchen Wang Andrew D Johnson Alicia Lundby Daníel F Gudbjartsson Peter A Noseworthy Mark Eijgelsheim Yuki Bradford Kirill V Tarasov Marcus Dörr Martina Müller-Nurasyid Annukka M Lahtinen Ilja M Nolte Albert Vernon Smith Joshua C Bis Aaron Isaacs Stephen J Newhouse Daniel S Evans Wendy S Post Daryl Waggott Leo-Pekka Lyytikäinen Andrew A Hicks Lewin Eisele David Ellinghaus Caroline Hayward Pau Navarro Sheila Ulivi Toshiko Tanaka David J Tester Stéphanie Chatel Stefan Gustafsson Meena Kumari Richard W Morris Åsa T Naluai Sandosh Padmanabhan Alexander Kluttig Bernhard Strohmer Andrie G Panayiotou Maria Torres Michael Knoflach Jaroslav A Hubacek Kamil Slowikowski Soumya Raychaudhuri Runjun D Kumar Tamara B Harris Lenore J Launer Alan R Shuldiner Alvaro Alonso Joel S Bader Georg Ehret Hailiang Huang W H Linda Kao James B Strait Peter W Macfarlane Morris Brown Mark J Caulfield Nilesh J Samani Florian Kronenberg Johann Willeit J Gustav Smith Karin H Greiser Henriette Meyer Zu Schwabedissen Karl Werdan Massimo Carella Leopoldo Zelante Susan R Heckbert Bruce M Psaty Jerome I Rotter Ivana Kolcic Ozren Polašek Alan F Wright Maura Griffin Mark J Daly David O Arnar Hilma Hólm Unnur Thorsteinsdottir Joshua C Denny Dan M Roden Rebecca L Zuvich Valur Emilsson Andrew S Plump Martin G Larson Christopher J O'Donnell Xiaoyan Yin Marco Bobbo Adamo P D'Adamo Annamaria Iorio Gianfranco Sinagra Angel Carracedo Steven R Cummings Michael A Nalls Antti Jula Kimmo K Kontula Annukka Marjamaa Lasse Oikarinen Markus Perola Kimmo Porthan Raimund Erbel Per Hoffmann Karl-Heinz Jöckel Hagen Kälsch Markus M Nöthen Marcel den Hoed Ruth J F Loos Dag S Thelle Christian Gieger Thomas Meitinger Siegfried Perz Annette Peters Hanna Prucha Moritz F Sinner Melanie Waldenberger Rudolf A de Boer Lude Franke Pieter A van der Vleuten Britt Maria Beckmann Eimo Martens Abdennasser Bardai Nynke Hofman Arthur A M Wilde Elijah R Behr Chrysoula Dalageorgou John R Giudicessi Argelia Medeiros-Domingo Julien Barc Florence Kyndt Vincent Probst Alice Ghidoni Roberto Insolia Robert M Hamilton Stephen W Scherer Jeffrey Brandimarto Kenneth Margulies Christine E Moravec Fabiola del Greco M Christian Fuchsberger Jeffrey R O'Connell Wai K Lee Graham C M Watt Harry Campbell Sarah H Wild Nour E El Mokhtari Norbert Frey Folkert W Asselbergs Irene Mateo Leach Gerjan Navis Maarten P van den Berg Dirk J van Veldhuisen Manolis Kellis Bouwe P Krijthe Oscar H Franco Albert Hofman Jan A Kors André G Uitterlinden Jacqueline C M Witteman Lyudmyla Kedenko Claudia Lamina Ben A Oostra Gonçalo R Abecasis Edward G Lakatta Antonella Mulas Marco Orrú David Schlessinger Manuela Uda Marcello R P Markus Uwe Völker Harold Snieder Timothy D Spector Johan Ärnlöv Lars Lind Johan Sundström Ann-Christine Syvänen Mika Kivimaki Mika Kähönen Nina Mononen Olli T Raitakari Jorma S Viikari Vera Adamkova Stefan Kiechl Maria Brion Andrew N Nicolaides Bernhard Paulweber Johannes Haerting Anna F Dominiczak Fredrik Nyberg Peter H Whincup Aroon D Hingorani Jean-Jacques Schott Connie R Bezzina Erik Ingelsson Luigi Ferrucci Paolo Gasparini James F Wilson Igor Rudan Andre Franke Thomas W Mühleisen Peter P Pramstaller Terho J Lehtimäki Andrew D Paterson Afshin Parsa Yongmei Liu Cornelia M van Duijn David S Siscovick Vilmundur Gudnason Yalda Jamshidi Veikko Salomaa Stephan B Felix Serena Sanna Marylyn D Ritchie Bruno H Stricker Kari Stefansson Laurie A Boyer Thomas P Cappola Jesper V Olsen Kasper Lage Peter J Schwartz Stefan Kääb Aravinda Chakravarti Michael J Ackerman Arne Pfeufer Paul I W de Bakker Christopher Newton-Cheh

Nat Genet 2014 Aug 22;46(8):826-36. Epub 2014 Jun 22.

1] Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, USA. [2] Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA. [3] Harvard Medical School, Boston, Massachusetts, USA. [4] Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts, USA. [5].

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http://dx.doi.org/10.1038/ng.3014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4124521PMC
August 2014

Synchronization of sinoatrial node pacemaker cell clocks and its autonomic modulation impart complexity to heart beating intervals.

Heart Rhythm 2014 Jul 5;11(7):1210-9. Epub 2014 Apr 5.

Laboratory of Cardiovascular Science, Biomedical Research Center, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, Maryland. Electronic address:

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http://dx.doi.org/10.1016/j.hrthm.2014.03.049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4065846PMC
July 2014

Gene-age interactions in blood pressure regulation: a large-scale investigation with the CHARGE, Global BPgen, and ICBP Consortia.

Authors:
Jeannette Simino Gang Shi Joshua C Bis Daniel I Chasman Georg B Ehret Xiangjun Gu Xiuqing Guo Shih-Jen Hwang Eric Sijbrands Albert V Smith Germaine C Verwoert Jennifer L Bragg-Gresham Gemma Cadby Peng Chen Ching-Yu Cheng Tanguy Corre Rudolf A de Boer Anuj Goel Toby Johnson Chiea-Chuen Khor Carla Lluís-Ganella Jian'an Luan Leo-Pekka Lyytikäinen Ilja M Nolte Xueling Sim Siim Sõber Peter J van der Most Niek Verweij Jing Hua Zhao Najaf Amin Eric Boerwinkle Claude Bouchard Abbas Dehghan Gudny Eiriksdottir Roberto Elosua Oscar H Franco Christian Gieger Tamara B Harris Serge Hercberg Albert Hofman Alan L James Andrew D Johnson Mika Kähönen Kay-Tee Khaw Zoltan Kutalik Martin G Larson Lenore J Launer Guo Li Jianjun Liu Kiang Liu Alanna C Morrison Gerjan Navis Rick Twee-Hee Ong George J Papanicolau Brenda W Penninx Bruce M Psaty Leslie J Raffel Olli T Raitakari Kenneth Rice Fernando Rivadeneira Lynda M Rose Serena Sanna Robert A Scott David S Siscovick Ronald P Stolk Andre G Uitterlinden Dhananjay Vaidya Melanie M van der Klauw Ramachandran S Vasan Eranga Nishanthie Vithana Uwe Völker Henry Völzke Hugh Watkins Terri L Young Tin Aung Murielle Bochud Martin Farrall Catharina A Hartman Maris Laan Edward G Lakatta Terho Lehtimäki Ruth J F Loos Gavin Lucas Pierre Meneton Lyle J Palmer Rainer Rettig Harold Snieder E Shyong Tai Yik-Ying Teo Pim van der Harst Nicholas J Wareham Cisca Wijmenga Tien Yin Wong Myriam Fornage Vilmundur Gudnason Daniel Levy Walter Palmas Paul M Ridker Jerome I Rotter Cornelia M van Duijn Jacqueline C M Witteman Aravinda Chakravarti Dabeeru C Rao

Am J Hum Genet 2014 Jul 19;95(1):24-38. Epub 2014 Jun 19.

Division of Biostatistics, Washington University School of Medicine, St. Louis, MO 63110, USA; Departments of Psychiatry, Genetics, and Mathematics, Washington University School of Medicine, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1016/j.ajhg.2014.05.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4085636PMC
July 2014

Age-associated abnormalities of intrinsic automaticity of sinoatrial nodal cells are linked to deficient cAMP-PKA-Ca(2+) signaling.

Am J Physiol Heart Circ Physiol 2014 May 14;306(10):H1385-97. Epub 2014 Mar 14.

Laboratory of Cardiovascular Science, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, Maryland; and

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http://dx.doi.org/10.1152/ajpheart.00088.2014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4024720PMC
May 2014

Hierarchical clustering of ryanodine receptors enables emergence of a calcium clock in sinoatrial node cells.

J Gen Physiol 2014 May;143(5):577-604

Laboratory of Cardiovascular Science, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224.

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http://dx.doi.org/10.1085/jgp.201311123DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4003189PMC
May 2014

Personality traits and circadian blood pressure patterns: a 7-year prospective study.

Psychosom Med 2014 Apr;76(3):237-43

From the Florida State University College of Medicine (A.T., A.R.S.), Tallahassee, Florida; National Institute on Aging, National Institutes of Health (A.T., J.S., O.M., A.R.S., K.T., J.D., E.L., D.S.), Baltimore, Maryland; Istituto di Neurogenetica e Neurofarmacologia (M.M., M.G.P., F.C.), Consiglio Nazionale delle Ricerche, Cagliari, Italy; Hospital San Raffaele Pisana IRCCS (A.S.), Rome, Italy; and Unità Operativa Complessa Cardiologia (M.O.), Presidio Ospedaliero A. Businco, Cagliari, Italy.

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http://dx.doi.org/10.1097/PSY.0000000000000035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4008636PMC
April 2014

GeneOptimizer program-assisted cDNA reengineering enhances sRAGE autologous expression in Chinese hamster ovary cells.

Protein Expr Purif 2014 Mar 25;95:143-8. Epub 2013 Dec 25.

Laboratory of Cardiovascular Sciences, National Institute on Aging, NIH, 251 Bayview Boulevard, Baltimore, MD 21224, United States. Electronic address:

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http://dx.doi.org/10.1016/j.pep.2013.12.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3936886PMC
March 2014

Impaired signaling intrinsic to sinoatrial node pacemaker cells affects heart rate variability during cardiac disease.

J Clin Trials 2014 Mar;4(1)

Laboratory of Cardiovascular Science, Biomedical Research Center, Intramural Research Program, National Institute on Aging, NIH, Baltimore, Maryland, USA.

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http://dx.doi.org/10.4172/2167-0870.1000152DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4524547PMC
March 2014

Proinflammation: the key to arterial aging.

Trends Endocrinol Metab 2014 Feb 20;25(2):72-9. Epub 2013 Dec 20.

Laboratory of Cardiovascular Science, National Institution on Aging, National Institutes of Health, Biomedical Research Center (BRC), 251 Bayview Boulevard, Baltimore, MD 21224, USA. Electronic address:

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http://dx.doi.org/10.1016/j.tem.2013.10.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3917314PMC
February 2014

Pacemaker gene mutations, bradycardia, arrhythmias and the coupled clock theory.

J Cardiovasc Electrophysiol 2013 Dec 9;24(12):E28-9. Epub 2013 Sep 9.

Laboratory of Cardiovascular Science Biomedical, Research Center Intramural Research Program, National Institute on Aging, NIH, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1111/jce.12236DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3855211PMC
December 2013

Relationship between inter-arm difference in systolic blood pressure and arterial stiffness in community-dwelling older adults.

J Clin Hypertens (Greenwich) 2013 Dec 7;15(12):880-7. Epub 2013 Aug 7.

Longitudinal Studies Section, Translational Gerontology Branch, NIA/NIH, Baltimore, MD; Laboratory of Cardiovascular Sciences, Human Cardiovascular Studies Unit, NIA/NIH, Baltimore, MD; Department of Internal Medicine, University of Genova, Genova, Italy.

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http://dx.doi.org/10.1111/jch.12178DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3855278PMC
December 2013

Longitudinal trajectories of arterial stiffness and the role of blood pressure: the Baltimore Longitudinal Study of Aging.

Hypertension 2013 Nov 3;62(5):934-41. Epub 2013 Sep 3.

Laboratory of Cardiovascular Science, Biomedical Research Center, 251 Bayview Blvd, Suite 100, Room 09B116, Baltimore, MD 21224.

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.113.01445DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3880832PMC
November 2013

Mechanisms of beat-to-beat regulation of cardiac pacemaker cell function by Ca²⁺ cycling dynamics.

Biophys J 2013 Oct;105(7):1551-61

Laboratory of Cardiovascular Science, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, Maryland.

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http://dx.doi.org/10.1016/j.bpj.2013.08.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3791306PMC
October 2013