Publications by authors named "Edward L Huttlin"

48Publications

Selection of Heating Temperatures Improves the Sensitivity of the Proteome Integral Solubility Alteration Assay.

Authors:
Jiaming Li Jonathan G Van Vranken Joao A Paulo Edward L Huttlin Steven P Gygi

J Proteome Res 2020 05 13;19(5):2159-2166. Epub 2020 Apr 13.

Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, United States.

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May 2020

TMTpro reagents: a set of isobaric labeling mass tags enables simultaneous proteome-wide measurements across 16 samples.

Authors:
Jiaming Li Jonathan G Van Vranken Laura Pontano Vaites Devin K Schweppe Edward L Huttlin Chris Etienne Premchendar Nandhikonda Rosa Viner Aaron M Robitaille Andrew H Thompson Karsten Kuhn Ian Pike Ryan D Bomgarden John C Rogers Steven P Gygi Joao A Paulo

Nat Methods 2020 04 16;17(4):399-404. Epub 2020 Mar 16.

Department of Cell Biology, Harvard Medical School, Boston, MA, USA.

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April 2020

Full-Featured, Real-Time Database Searching Platform Enables Fast and Accurate Multiplexed Quantitative Proteomics.

Authors:
Devin K Schweppe Jimmy K Eng Qing Yu Derek Bailey Ramin Rad Jose Navarrete-Perea Edward L Huttlin Brian K Erickson Joao A Paulo Steven P Gygi

J Proteome Res 2020 05 6;19(5):2026-2034. Epub 2020 Apr 6.

Harvard Medical School, Department of Cell Biology, Cambridge, Massachusetts 02155, United States.

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May 2020

A Quantitative Tissue-Specific Landscape of Protein Redox Regulation during Aging.

Authors:
Haopeng Xiao Mark P Jedrychowski Devin K Schweppe Edward L Huttlin Qing Yu David E Heppner Jiaming Li Jiani Long Evanna L Mills John Szpyt Zhixiang He Guangyan Du Ryan Garrity Anita Reddy Laura Pontano Vaites Joao A Paulo Tinghu Zhang Nathanael S Gray Steven P Gygi Edward T Chouchani

Cell 2020 03 27;180(5):968-983.e24. Epub 2020 Feb 27.

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA; Department of Cell Biology, Harvard Medical School, Boston, MA, USA. Electronic address:

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March 2020

Human cytomegalovirus interactome analysis identifies degradation hubs, domain associations and viral protein functions.

Authors:
Luis V Nobre Katie Nightingale Benjamin J Ravenhill Robin Antrobus Lior Soday Jenna Nichols James A Davies Sepehr Seirafian Eddie Cy Wang Andrew J Davison Gavin Wg Wilkinson Richard J Stanton Edward L Huttlin Michael P Weekes

Elife 2019 12 24;8. Epub 2019 Dec 24.

Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom.

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December 2019

Investigation of Proteomic and Phosphoproteomic Responses to Signaling Network Perturbations Reveals Functional Pathway Organizations in Yeast.

Authors:
Jiaming Li Joao A Paulo David P Nusinow Edward L Huttlin Steven P Gygi

Cell Rep 2019 11;29(7):2092-2104.e4

Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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November 2019

High-Definition Analysis of Host Protein Stability during Human Cytomegalovirus Infection Reveals Antiviral Factors and Viral Evasion Mechanisms.

Authors:
Katie Nightingale Kai-Min Lin Benjamin J Ravenhill Colin Davies Luis Nobre Ceri A Fielding Eva Ruckova Alice Fletcher-Etherington Lior Soday Hester Nichols Daniel Sugrue Eddie C Y Wang Pablo Moreno Yagnesh Umrania Edward L Huttlin Robin Antrobus Andrew J Davison Gavin W G Wilkinson Richard J Stanton Peter Tomasec Michael P Weekes

Cell Host Microbe 2018 09 16;24(3):447-460.e11. Epub 2018 Aug 16.

Cambridge Institute for Medical Research, University of Cambridge, Hills Road, Cambridge CB2 0XY, UK. Electronic address:

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September 2018

Characterization of Plasmodium falciparum Atypical Kinase PfPK7 Dependent Phosphoproteome.

Authors:
Brittany N Pease Edward L Huttlin Mark P Jedrychowski Dominique Dorin-Semblat Daniela Sebastiani Daniel T Segarra Bracken F Roberts Ratna Chakrabarti Christian Doerig Steven P Gygi Debopam Chakrabarti

J Proteome Res 2018 06 30;17(6):2112-2123. Epub 2018 Apr 30.

Division of Molecular Biology and Microbiology, Burnett School of Biomedical Sciences , University of Central Florida , Orlando , Florida 32826 , United States.

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June 2018

DNAJC12: A molecular chaperone involved in proteostasis, PKU, biogenic amines metabolism and beyond?

Authors:
Juliette Bouchereau Edward L Huttlin Virginia Guarani Samia Pichard Yair Anikster Manuel Schiff

Mol Genet Metab 2018 03 12;123(3):285-286. Epub 2018 Feb 12.

Reference Center for Inborn Errors of Metabolism, Robert Debré University Hospital, APHP, Paris 75019, France; Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel. Electronic address:

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March 2018

Compositional Proteomics: Effects of Spatial Constraints on Protein Quantification Utilizing Isobaric Tags.

Authors:
Jonathon J O'Brien Jeremy D O'Connell Joao A Paulo Sanjukta Thakurta Christopher M Rose Michael P Weekes Edward L Huttlin Steven P Gygi

J Proteome Res 2018 01 15;17(1):590-599. Epub 2017 Dec 15.

Department of Cell Biology, Harvard Medical School , Boston, Massachusetts 02115, United States.

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January 2018

BioPlex Display: An Interactive Suite for Large-Scale AP-MS Protein-Protein Interaction Data.

Authors:
Devin K Schweppe Edward L Huttlin J Wade Harper Steven P Gygi

J Proteome Res 2018 01 31;17(1):722-726. Epub 2017 Oct 31.

Department of Cell Biology, Harvard Medical School , Boston, Massachusetts 02115, United States.

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January 2018

Systematic Analysis of Human Cells Lacking ATG8 Proteins Uncovers Roles for GABARAPs and the CCZ1/MON1 Regulator C18orf8/RMC1 in Macroautophagic and Selective Autophagic Flux.

Authors:
Laura Pontano Vaites Joao A Paulo Edward L Huttlin J Wade Harper

Mol Cell Biol 2018 01 13;38(1). Epub 2017 Dec 13.

Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, USA

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January 2018

Architecture of the human interactome defines protein communities and disease networks.

Authors:
Edward L Huttlin Raphael J Bruckner Joao A Paulo Joe R Cannon Lily Ting Kurt Baltier Greg Colby Fana Gebreab Melanie P Gygi Hannah Parzen John Szpyt Stanley Tam Gabriela Zarraga Laura Pontano-Vaites Sharan Swarup Anne E White Devin K Schweppe Ramin Rad Brian K Erickson Robert A Obar K G Guruharsha Kejie Li Spyros Artavanis-Tsakonas Steven P Gygi J Wade Harper

Nature 2017 05 17;545(7655):505-509. Epub 2017 May 17.

Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA.

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May 2017

Biallelic Mutations in DNAJC12 Cause Hyperphenylalaninemia, Dystonia, and Intellectual Disability.

Authors:
Yair Anikster Tobias B Haack Thierry Vilboux Ben Pode-Shakked Beat Thöny Nan Shen Virginia Guarani Thomas Meissner Ertan Mayatepek Friedrich K Trefz Dina Marek-Yagel Aurora Martinez Edward L Huttlin Joao A Paulo Riccardo Berutti Jean-François Benoist Apolline Imbard Imen Dorboz Gali Heimer Yuval Landau Limor Ziv-Strasser May Christine V Malicdan Corinne Gemperle-Britschgi Kirsten Cremer Hartmut Engels David Meili Irene Keller Rémy Bruggmann Tim M Strom Thomas Meitinger James C Mullikin Gerard Schwartz Bruria Ben-Zeev William A Gahl J Wade Harper Nenad Blau Georg F Hoffmann Holger Prokisch Thomas Opladen Manuel Schiff

Am J Hum Genet 2017 02 26;100(2):257-266. Epub 2017 Jan 26.

UMR1141, PROTECT, INSERM, Université Paris Diderot, Sorbonne Paris Cité, Paris 75019, France; Reference Center for Inborn Errors of Metabolism, Robert Debré University Hospital, APHP, Paris 75019, France. Electronic address:

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February 2017

Neutral Loss Is a Very Common Occurrence in Phosphotyrosine-Containing Peptides Labeled with Isobaric Tags.

Authors:
Robert A Everley Edward L Huttlin Alison R Erickson Sean A Beausoleil Steven P Gygi

J Proteome Res 2017 02 30;16(2):1069-1076. Epub 2016 Dec 30.

Department of Cell Biology, Harvard Medical School , Boston, Massachusetts 02115, United States.

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February 2017

Defining the consequences of genetic variation on a proteome-wide scale.

Authors:
Joel M Chick Steven C Munger Petr Simecek Edward L Huttlin Kwangbom Choi Daniel M Gatti Narayanan Raghupathy Karen L Svenson Gary A Churchill Steven P Gygi

Nature 2016 06 15;534(7608):500-5. Epub 2016 Jun 15.

Harvard Medical School, Boston, Massachusetts 02115, USA.

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June 2016

Corrigendum: Systematic proteomics of the VCP-UBXD adaptor network identifies a role for UBXN10 in regulating ciliogenesis.

Authors:
Malavika Raman Mikhail Sergeev Maija Garnaas John R Lydeard Edward L Huttlin Wolfram Goessling Jagesh V Shah J Wade Harper

Nat Cell Biol 2016 Mar;18(3):347

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March 2016

Systematic proteomics of the VCP-UBXD adaptor network identifies a role for UBXN10 in regulating ciliogenesis.

Authors:
Malavika Raman Mikhail Sergeev Maija Garnaas John R Lydeard Edward L Huttlin Wolfram Goessling Jagesh V Shah J Wade Harper

Nat Cell Biol 2015 Oct 21;17(10):1356-69. Epub 2015 Sep 21.

Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, Massachusetts 02115, USA.

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October 2015

Erratum: A mass-tolerant database search identifies a large proportion of unassigned spectra in shotgun proteomics as modified peptides.

Authors:
Joel M Chick Deepak Kolippakkam David P Nusinow Bo Zhai Ramin Rad Edward L Huttlin Steven P Gygi

Nat Biotechnol 2015 Aug;33(8):882

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August 2015

The BioPlex Network: A Systematic Exploration of the Human Interactome.

Authors:
Edward L Huttlin Lily Ting Raphael J Bruckner Fana Gebreab Melanie P Gygi John Szpyt Stanley Tam Gabriela Zarraga Greg Colby Kurt Baltier Rui Dong Virginia Guarani Laura Pontano Vaites Alban Ordureau Ramin Rad Brian K Erickson Martin Wühr Joel Chick Bo Zhai Deepak Kolippakkam Julian Mintseris Robert A Obar Tim Harris Spyros Artavanis-Tsakonas Mathew E Sowa Pietro De Camilli Joao A Paulo J Wade Harper Steven P Gygi

Cell 2015 Jul;162(2):425-440

Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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July 2015