Edward H Koo

Edward H Koo

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Edward H Koo

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Cerebral transcriptome analysis reveals age-dependent progression of neuroinflammation in P301S mutant tau transgenic male mice.

Brain Behav Immun 2019 Aug 11;80:344-357. Epub 2019 Apr 11.

Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; School of Pharmacy, Sungkyunkwan University, Suwon, Gyeonggi-do, Republic of Korea; Neurobiology Programme, Life Sciences Institute, National University of Singapore, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.bbi.2019.04.011DOI Listing
August 2019

Evidence that NLRC4 inflammasome mediates apoptotic and pyroptotic microglial death following ischemic stroke.

Brain Behav Immun 2019 01 5;75:34-47. Epub 2018 Sep 5.

Department of Physiology, Yong Loo Lin School Medicine, National University of Singapore, Singapore; School of Pharmacy, Sungkyunkwan University, Suwon, Republic of Korea; Neurobiology/Ageing Programme, Life Sciences Institute, National University of Singapore, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.bbi.2018.09.001DOI Listing
January 2019

APP upregulation contributes to retinal ganglion cell degeneration via JNK3.

Cell Death Differ 2018 03 13;25(4):663-678. Epub 2017 Dec 13.

Department of Pharmacology, Yong Loo Lin School of Medicine, National University Health System, National University of Singapore, 16 Medical Drive, Singapore, 117600, Singapore.

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http://www.nature.com/articles/s41418-017-0005-3
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http://dx.doi.org/10.1038/s41418-017-0005-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5864187PMC
March 2018

Transcriptional regulation of APP by apoE: To boldly go where no isoform has gone before: ApoE, APP transcription and AD: Hypothesised mechanisms and existing knowledge gaps.

Bioessays 2017 09 21;39(9). Epub 2017 Jul 21.

Department of Medicine, Yong Loo Lin School of Medicine, National University Health System, Singapore, Singapore.

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http://dx.doi.org/10.1002/bies.201700062DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5647194PMC
September 2017

The Utility of Brief Cognitive Tests for Patients With Type 2 Diabetes Mellitus: A Systematic Review.

J Am Med Dir Assoc 2016 10 25;17(10):889-95. Epub 2016 Jul 25.

Department of Medicine, National University Hospital, Singapore; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

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http://dx.doi.org/10.1016/j.jamda.2016.06.010DOI Listing
October 2016

Deficiency in either COX-1 or COX-2 genes does not affect amyloid beta protein burden in amyloid precursor protein transgenic mice.

Biochem Biophys Res Commun 2016 09 15;478(1):286-292. Epub 2016 Jul 15.

Department of Neurosciences, University of California, San Diego, CA 92037, USA; Departments of Medicine and Physiology, National University of Singapore, Yong Loo Lin School of Medicine, Singapore, 117597, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2016.07.015DOI Listing
September 2016

Modulation of Aβ42 in vivo by γ-secretase modulator in primates and humans.

Alzheimers Res Ther 2015 5;7(1):55. Epub 2015 Aug 5.

Department of Neurosciences, University of California, La Jolla, San Diego, CA USA ; Departments of Medicine and Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.

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http://alzres.com/content/7/1/55
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http://dx.doi.org/10.1186/s13195-015-0137-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4523931PMC
May 2016

Independent relationship between amyloid precursor protein (APP) dimerization and γ-secretase processivity.

PLoS One 2014 28;9(10):e111553. Epub 2014 Oct 28.

Center for Translational Research in Neurodegenerative Disease, University of Florida, Gainesville, Florida, United States of America; Department of Neuroscience, University of Florida, Gainesville, Florida, United States of America; McKnight Brain Institute, College of Medicine, University of Florida, Gainesville, Florida, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0111553PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4211736PMC
January 2016

Visualizing APP and BACE-1 approximation in neurons yields insight into the amyloidogenic pathway.

Nat Neurosci 2016 Jan 7;19(1):55-64. Epub 2015 Dec 7.

Department of Pathology, University of California, San Diego, La Jolla, California, USA.

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http://dx.doi.org/10.1038/nn.4188DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4782935PMC
January 2016

Inter-Dependent Mechanisms Behind Cognitive Dysfunction, Vascular Biology and Alzheimer's Dementia in Down Syndrome: Multi-Faceted Roles of APP.

Front Behav Neurosci 2015 1;9:299. Epub 2015 Dec 1.

Departments of Medicine and Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore Singapore ; Department of Neurosciences, University of California, San Diego San Diego, CA, USA.

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http://dx.doi.org/10.3389/fnbeh.2015.00299DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4664698PMC
December 2015

New tricks from an old dog: Another synaptotoxic fragment from APP.

Cell Res 2015 Nov 27;25(11):1185-6. Epub 2015 Oct 27.

Department of Medicine, National University of Singapore, Singapore.

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http://dx.doi.org/10.1038/cr.2015.125DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4650427PMC
November 2015

Rarity of the Alzheimer disease-protective APP A673T variant in the United States.

Authors:
Li-San Wang Adam C Naj Robert R Graham Paul K Crane Brian W Kunkle Carlos Cruchaga Josue D Gonzalez Murcia Lisa Cannon-Albright Clinton T Baldwin Henrik Zetterberg Kaj Blennow Walter A Kukull Kelley M Faber Nicole Schupf Maria C Norton JoAnn T Tschanz Ronald G Munger Christopher D Corcoran Ekaterina Rogaeva Chiao-Feng Lin Beth A Dombroski Laura B Cantwell Amanda Partch Otto Valladares Hakon Hakonarson Peter St George-Hyslop Robert C Green Alison M Goate Tatiana M Foroud Regina M Carney Eric B Larson Timothy W Behrens John S K Kauwe Jonathan L Haines Lindsay A Farrer Margaret A Pericak-Vance Richard Mayeux Gerard D Schellenberg Marilyn S Albert Roger L Albin Liana G Apostolova Steven E Arnold Robert Barber Michael Barmada Lisa L Barnes Thomas G Beach James T Becker Gary W Beecham Duane Beekly David A Bennett Eileen H Bigio Thomas D Bird Deborah Blacker Bradley F Boeve James D Bowen Adam Boxer James R Burke Joseph D Buxbaum Nigel J Cairns Chuanhai Cao Chris S Carlson Steven L Carroll Helena C Chui David G Clark David H Cribbs Elizabeth A Crocco Charles DeCarli Steven T DeKosky F Yesim Demirci Malcolm Dick Dennis W Dickson Ranjan Duara Nilufer Ertekin-Taner Kenneth B Fallon Martin R Farlow Steven Ferris Matthew P Frosch Douglas R Galasko Mary Ganguli Marla Gearing Daniel H Geschwind Bernardino Ghetti John R Gilbert Jonathan D Glass Neill R Graff-Radford John H Growdon Ronald L Hamilton Kara L Hamilton-Nelson Lindy E Harrell Elizabeth Head Lawrence S Honig Christine M Hulette Bradley T Hyman Gail P Jarvik Gregory A Jicha Lee-Way Jin Gyungah Jun Gyungah Jun M Ilyas Kamboh Anna Karydas Jeffrey A Kaye Ronald Kim Edward H Koo Neil W Kowall Joel H Kramer Frank M LaFerla James J Lah James B Leverenz Allan I Levey Gei Li Andrew P Lieberman Oscar L Lopez Kathryn L Lunetta Constantine G Lyketsos Wendy J Mack Daniel C Marson Eden R Martin Frank Martiniuk Deborah C Mash Eliezer Masliah Wayne C McCormick Susan M McCurry Andrew N McDavid Ann C McKee W Marsel Mesulam Bruce L Miller Carol A Miller Joshua W Miller Thomas J Montine John C Morris Jill R Murrell John M Olichney Joseph E Parisi William Perry Elaine Peskind Ronald C Petersen Aimee Pierce Wayne W Poon Huntington Potter Joseph F Quinn Ashok Raj Murray Raskind Eric M Reiman Barry Reisberg Christiane Reitz John M Ringman Erik D Roberson Howard J Rosen Roger N Rosenberg Mary Sano Andrew J Saykin Julie A Schneider Lon S Schneider William W Seeley Amanda G Smith Joshua A Sonnen Salvatore Spina Robert A Stern Rudolph E Tanzi Tricia A Thornton-Wells John Q Trojanowski Juan C Troncoso Debby W Tsuang Vivianna M Van Deerlin Linda J Van Eldik Badri N Vardarajan Harry V Vinters Jean Paul Vonsattel Sandra Weintraub Kathleen A Welsh-Bohmer Jennifer Williamson Sarah Wishnek Randall L Woltjer Clinton B Wright Steven G Younkin Chang-En Yu Lei Yu

JAMA Neurol 2015 Feb;72(2):209-16

Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia.

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http://dx.doi.org/10.1001/jamaneurol.2014.2157DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4324097PMC
February 2015

The multifaceted nature of amyloid precursor protein and its proteolytic fragments: friends and foes.

Acta Neuropathol 2015 Jan 7;129(1):1-19. Epub 2014 Oct 7.

Department of Neurosciences, University of California, San Diego, La Jolla, CA, USA,

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http://dx.doi.org/10.1007/s00401-014-1347-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4282969PMC
January 2015

Effects of multiple genetic loci on age at onset in late-onset Alzheimer disease: a genome-wide association study.

Authors:
Adam C Naj Gyungah Jun Christiane Reitz Brian W Kunkle William Perry Yo Son Park Gary W Beecham Ruchita A Rajbhandary Kara L Hamilton-Nelson Li-San Wang John S K Kauwe Matthew J Huentelman Amanda J Myers Thomas D Bird Bradley F Boeve Clinton T Baldwin Gail P Jarvik Paul K Crane Ekaterina Rogaeva M Michael Barmada F Yesim Demirci Carlos Cruchaga Patricia L Kramer Nilufer Ertekin-Taner John Hardy Neill R Graff-Radford Robert C Green Eric B Larson Peter H St George-Hyslop Joseph D Buxbaum Denis A Evans Julie A Schneider Kathryn L Lunetta M Ilyas Kamboh Andrew J Saykin Eric M Reiman Philip L De Jager David A Bennett John C Morris Thomas J Montine Alison M Goate Deborah Blacker Debby W Tsuang Hakon Hakonarson Walter A Kukull Tatiana M Foroud Eden R Martin Jonathan L Haines Richard P Mayeux Lindsay A Farrer Gerard D Schellenberg Margaret A Pericak-Vance Marilyn S Albert Roger L Albin Liana G Apostolova Steven E Arnold Robert Barber Lisa L Barnes Thomas G Beach James T Becker Duane Beekly Eileen H Bigio James D Bowen Adam Boxer James R Burke Nigel J Cairns Laura B Cantwell Chuanhai Cao Chris S Carlson Regina M Carney Minerva M Carrasquillo Steven L Carroll Helena C Chui David G Clark Jason Corneveaux David H Cribbs Elizabeth A Crocco Charles DeCarli Steven T DeKosky Malcolm Dick Dennis W Dickson Ranjan Duara Kelley M Faber Kenneth B Fallon Martin R Farlow Steven Ferris Matthew P Frosch Douglas R Galasko Mary Ganguli Marla Gearing Daniel H Geschwind Bernardino Ghetti John R Gilbert Jonathan D Glass John H Growdon Ronald L Hamilton Lindy E Harrell Elizabeth Head Lawrence S Honig Christine M Hulette Bradley T Hyman Gregory A Jicha Lee-Way Jin Anna Karydas Jeffrey A Kaye Ronald Kim Edward H Koo Neil W Kowall Joel H Kramer Frank M LaFerla James J Lah James B Leverenz Allan I Levey Ge Li Andrew P Lieberman Chiao-Feng Lin Oscar L Lopez Constantine G Lyketsos Wendy J Mack Frank Martiniuk Deborah C Mash Eliezer Masliah Wayne C McCormick Susan M McCurry Andrew N McDavid Ann C McKee Marsel Mesulam Bruce L Miller Carol A Miller Joshua W Miller Jill R Murrell John M Olichney Vernon S Pankratz Joseph E Parisi Henry L Paulson Elaine Peskind Ronald C Petersen Aimee Pierce Wayne W Poon Huntington Potter Joseph F Quinn Ashok Raj Murray Raskind Barry Reisberg John M Ringman Erik D Roberson Howard J Rosen Roger N Rosenberg Mary Sano Lon S Schneider William W Seeley Amanda G Smith Joshua A Sonnen Salvatore Spina Robert A Stern Rudolph E Tanzi Tricia A Thornton-Wells John Q Trojanowski Juan C Troncoso Otto Valladares Vivianna M Van Deerlin Linda J Van Eldik Badri N Vardarajan Harry V Vinters Jean Paul Vonsattel Sandra Weintraub Kathleen A Welsh-Bohmer Jennifer Williamson Sarah Wishnek Randall L Woltjer Clinton B Wright Steven G Younkin Chang-En Yu Lei Yu

JAMA Neurol 2014 Nov;71(11):1394-404

Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois.

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http://dx.doi.org/10.1001/jamaneurol.2014.1491DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4314944PMC
November 2014

Emerging therapeutics for Alzheimer's disease.

Annu Rev Pharmacol Toxicol 2014 ;54:381-405

Department of Neurosciences, University of California, San Diego, La Jolla, California 92093; email: ,

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http://dx.doi.org/10.1146/annurev-pharmtox-011613-135932DOI Listing
September 2014

Specific disruption of hippocampal mossy fiber synapses in a mouse model of familial Alzheimer's disease.

PLoS One 2014 13;9(1):e84349. Epub 2014 Jan 13.

Neurobiology Section, Division of Biological Sciences, University of California San Diego, La Jolla, California, United States of America ; Neuroscience Discovery and Translational Area, pRED, F. Hoffmann-La Roche, Basel, Switzerland.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0084349PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3890281PMC
September 2014

Complex relationships between substrate sequence and sensitivity to alterations in γ-secretase processivity induced by γ-secretase modulators.

Biochemistry 2014 Apr 20;53(12):1947-57. Epub 2014 Mar 20.

Center for Translational Research in Neurodegenerative Disease, Department of Neuroscience, and McKnight Brain Institute, College of Medicine, University of Florida , Gainesville, Florida 32603, United States.

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http://dx.doi.org/10.1021/bi401521tDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3985764PMC
April 2014

γ-Secretase inhibitors and modulators.

Biochim Biophys Acta 2013 Dec 17;1828(12):2898-907. Epub 2013 Jun 17.

Center for Translational Research in Neurodegenerative Disease, Department of Neuroscience, McKnight Brain Institute, College of Medicine, University of Florida, Gainesville, FL 32610, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bbamem.2013.06.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3857966PMC
December 2013

The--YENPTY--domain of the amyloid precursor protein: much more than just endocytosis?

Bioessays 2013 Oct;35(10):844

Department of Neurosciences, University of California, San Diego, USA.

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http://dx.doi.org/10.1002/bies.201300120DOI Listing
October 2013

Steroids as γ-secretase modulators.

FASEB J 2013 Sep 28;27(9):3775-85. Epub 2013 May 28.

Center for Translational Research in Neurodegenerative Disease and Department of Neuroscience, College of Medicine, University of Florida, Gainesville, FL 32610, USA.

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http://dx.doi.org/10.1096/fj.12-225649DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3752532PMC
September 2013

Early BDNF treatment ameliorates cell loss in the entorhinal cortex of APP transgenic mice.

J Neurosci 2013 Sep;33(39):15596-602

Department of Neurosciences-0626, University of California, San Diego, La Jolla, California 92093, and Veterans Affairs Medical Center, San Diego, California 92161.

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http://dx.doi.org/10.1523/JNEUROSCI.5195-12.2013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3782628PMC
September 2013

Activity-induced convergence of APP and BACE-1 in acidic microdomains via an endocytosis-dependent pathway.

Neuron 2013 Aug;79(3):447-60

Department of Pathology, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.

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http://dx.doi.org/10.1016/j.neuron.2013.05.035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3741682PMC
August 2013

Asp664 cleavage of amyloid precursor protein induces tau phosphorylation by decreasing protein phosphatase 2A activity.

J Neurochem 2012 Dec 25;123(5):856-65. Epub 2012 Oct 25.

Department of Neurology, Soonchunhyang University Bucheon Hospital, Bucheon, Korea.

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http://dx.doi.org/10.1111/jnc.12032DOI Listing
December 2012

Amyloid precursor protein (APP) regulates synaptic structure and function.

Mol Cell Neurosci 2012 Aug 3;51(1-2):43-52. Epub 2012 Aug 3.

Department of Neurosciences, University of California San Diego, La Jolla, CA 92093, USA.

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http://dx.doi.org/10.1016/j.mcn.2012.07.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3538857PMC
August 2012

Novel late-onset Alzheimer disease loci variants associate with brain gene expression.

Authors:
Mariet Allen Fanggeng Zou High Seng Chai Curtis S Younkin Julia Crook V Shane Pankratz Minerva M Carrasquillo Christopher N Rowley Asha A Nair Sumit Middha Sooraj Maharjan Thuy Nguyen Li Ma Kimberly G Malphrus Ryan Palusak Sarah Lincoln Gina Bisceglio Constantin Georgescu Debra Schultz Fariborz Rakhshan Christopher P Kolbert Jin Jen Jonathan L Haines Richard Mayeux Margaret A Pericak-Vance Lindsay A Farrer Gerard D Schellenberg Ronald C Petersen Neill R Graff-Radford Dennis W Dickson Steven G Younkin Nilüfer Ertekin-Taner Liana G Apostolova Steven E Arnold Clinton T Baldwin Robert Barber Michael M Barmada Thomas Beach Gary W Beecham Duane Beekly David A Bennett Eileen H Bigio Thomas D Bird Deborah Blacker Bradley F Boeve James D Bowen Adam Boxer James R Burke Jacqueline Buros Joseph D Buxbaum Nigel J Cairns Laura B Cantwell Chuanhai Cao Chris S Carlson Regina M Carney Steven L Carroll Helena C Chui David G Clark Jason Corneveaux Carl W Cotman Paul K Crane Carlos Cruchaga Jeffrey L Cummings Philip L De Jager Charles DeCarli Steven T DeKosky F Yesim Demirci Ramon Diaz-Arrastia Malcolm Dick Beth A Dombroski Ranjan Duara William D Ellis Denis Evans Kelley M Faber Kenneth B Fallon Martin R Farlow Steven Ferris Tatiana M Foroud Matthew Frosch Douglas R Galasko Paul J Gallins Mary Ganguli Marla Gearing Daniel H Geschwind Bernardino Ghetti John R Gilbert Sid Gilman Bruno Giordani Jonathan D Glass Alison M Goate Robert C Green John H Growdon Hakon Hakonarson Ronald L Hamilton John Hardy Lindy E Harrell Elizabeth Head Lawrence S Honig Matthew J Huentelman Christine M Hulette Bradley T Hyman Gail P Jarvik Gregory A Jicha Lee-Way Jin Gyungah Jun M Ilyas Kamboh Jason Karlawish Anna Karydas John S K Kauwe Jeffrey A Kaye Nancy Kennedy Ronald Kim Edward H Koo Neil W Kowall Patricia Kramer Walter A Kukull James J Lah Eric B Larson Allan I Levey Andrew P Lieberman Oscar L Lopez Kathryn L Lunetta Wendy J Mack Daniel C Marson Eden R Martin Frank Martiniuk Deborah C Mash Eliezer Masliah Wayne C McCormick Susan M McCurry Andrew N McDavid Ann C McKee Marsel Mesulam Bruce L Miller Carol A Miller Joshua W Miller Thomas J Montine John C Morris Amanda J Myers Adam C Naj Petra Nowotny Joseph E Parisi Daniel P Perl Elaine Peskind Wayne W Poon Huntington Potter Joseph F Quinn Ashok Raj Ruchita A Rajbhandary Murray Raskind Eric M Reiman Barry Reisberg Christiane Reitz John M Ringman Erik D Roberson Ekaterina Rogaeva Roger N Rosenberg Mary Sano Andrew J Saykin Julie A Schneider Lon S Schneider William Seeley Michael L Shelanski Michael A Slifer Charles D Smith Joshua A Sonnen Salvatore Spina Peter St George-Hyslop Robert A Stern Rudolph E Tanzi John Q Trojanowski Juan C Troncoso Debby W Tsuang Vivianna M Van Deerlin Badri Narayan Vardarajan Harry V Vinters Jean Paul Vonsattel Li-San Wang Sandra Weintraub Kathleen A Welsh-Bohmer Jennifer Williamson Randall L Woltjer

Neurology 2012 Jul 20;79(3):221-8. Epub 2012 Jun 20.

Department of Neuroscience, Biostatistics Unit, Mayo Clinic Florida, Jacksonville, FL, USA.

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http://dx.doi.org/10.1212/WNL.0b013e3182605801DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3398432PMC
July 2012

Role of RanBP9 on amyloidogenic processing of APP and synaptic protein levels in the mouse brain.

FASEB J 2012 May 31;26(5):2072-83. Epub 2012 Jan 31.

Section of Neurobiology, Torrey Pines Institute for Molecular Studies, Port Saint Lucie, Florida, USA.

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http://dx.doi.org/10.1096/fj.11-196709DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3336780PMC
May 2012

Early and selective impairments in axonal transport kinetics of synaptic cargoes induced by soluble amyloid β-protein oligomers.

Traffic 2012 May 27;13(5):681-93. Epub 2012 Feb 27.

Department of Pathology, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.

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http://dx.doi.org/10.1111/j.1600-0854.2012.01340.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3593673PMC
May 2012

Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease.

Authors:
Adam C Naj Gyungah Jun Gary W Beecham Li-San Wang Badri Narayan Vardarajan Jacqueline Buros Paul J Gallins Joseph D Buxbaum Gail P Jarvik Paul K Crane Eric B Larson Thomas D Bird Bradley F Boeve Neill R Graff-Radford Philip L De Jager Denis Evans Julie A Schneider Minerva M Carrasquillo Nilufer Ertekin-Taner Steven G Younkin Carlos Cruchaga John S K Kauwe Petra Nowotny Patricia Kramer John Hardy Matthew J Huentelman Amanda J Myers Michael M Barmada F Yesim Demirci Clinton T Baldwin Robert C Green Ekaterina Rogaeva Peter St George-Hyslop Steven E Arnold Robert Barber Thomas Beach Eileen H Bigio James D Bowen Adam Boxer James R Burke Nigel J Cairns Chris S Carlson Regina M Carney Steven L Carroll Helena C Chui David G Clark Jason Corneveaux Carl W Cotman Jeffrey L Cummings Charles DeCarli Steven T DeKosky Ramon Diaz-Arrastia Malcolm Dick Dennis W Dickson William G Ellis Kelley M Faber Kenneth B Fallon Martin R Farlow Steven Ferris Matthew P Frosch Douglas R Galasko Mary Ganguli Marla Gearing Daniel H Geschwind Bernardino Ghetti John R Gilbert Sid Gilman Bruno Giordani Jonathan D Glass John H Growdon Ronald L Hamilton Lindy E Harrell Elizabeth Head Lawrence S Honig Christine M Hulette Bradley T Hyman Gregory A Jicha Lee-Way Jin Nancy Johnson Jason Karlawish Anna Karydas Jeffrey A Kaye Ronald Kim Edward H Koo Neil W Kowall James J Lah Allan I Levey Andrew P Lieberman Oscar L Lopez Wendy J Mack Daniel C Marson Frank Martiniuk Deborah C Mash Eliezer Masliah Wayne C McCormick Susan M McCurry Andrew N McDavid Ann C McKee Marsel Mesulam Bruce L Miller Carol A Miller Joshua W Miller Joseph E Parisi Daniel P Perl Elaine Peskind Ronald C Petersen Wayne W Poon Joseph F Quinn Ruchita A Rajbhandary Murray Raskind Barry Reisberg John M Ringman Erik D Roberson Roger N Rosenberg Mary Sano Lon S Schneider William Seeley Michael L Shelanski Michael A Slifer Charles D Smith Joshua A Sonnen Salvatore Spina Robert A Stern Rudolph E Tanzi John Q Trojanowski Juan C Troncoso Vivianna M Van Deerlin Harry V Vinters Jean Paul Vonsattel Sandra Weintraub Kathleen A Welsh-Bohmer Jennifer Williamson Randall L Woltjer Laura B Cantwell Beth A Dombroski Duane Beekly Kathryn L Lunetta Eden R Martin M Ilyas Kamboh Andrew J Saykin Eric M Reiman David A Bennett John C Morris Thomas J Montine Alison M Goate Deborah Blacker Debby W Tsuang Hakon Hakonarson Walter A Kukull Tatiana M Foroud Jonathan L Haines Richard Mayeux Margaret A Pericak-Vance Lindsay A Farrer Gerard D Schellenberg

Nat Genet 2011 May 3;43(5):436-41. Epub 2011 Apr 3.

The John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, USA.

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http://dx.doi.org/10.1038/ng.801DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3090745PMC
May 2011

Biology and pathophysiology of the amyloid precursor protein.

Mol Neurodegener 2011 Apr 28;6(1):27. Epub 2011 Apr 28.

Huffington Center on Aging and Department of Molecular & Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.

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http://dx.doi.org/10.1186/1750-1326-6-27DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3098799PMC
April 2011

Anti-aβ therapeutics in Alzheimer's disease: the need for a paradigm shift.

Neuron 2011 Jan;69(2):203-13

Center for Translational Research in Neurodegenerative Disease and Department of Neuroscience, College of Medicine, University of Florida, 1275 Center Drive BMS J-483, P.O. Box 100159, Gainesville, FL 32610-0244, USA.

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http://dx.doi.org/10.1016/j.neuron.2011.01.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3058906PMC
January 2011

And four equals one: presenilin takes the gamma-secretase role by itself.

Proc Natl Acad Sci U S A 2010 Dec 6;107(50):21236-7. Epub 2010 Dec 6.

Department of Neurosciences, University of California at San Diego, La Jolla, CA 92093, USA.

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http://dx.doi.org/10.1073/pnas.1016284108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3003118PMC
December 2010

Substrate docking to γ-secretase allows access of γ-secretase modulators to an allosteric site.

Nat Commun 2010 Nov 30;1:130. Epub 2010 Nov 30.

1] Alzheimer Research Unit, MassGeneral Institute for Neurodegenerative Diseases, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA. [2].

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http://www.nature.com/doifinder/10.1038/ncomms1129
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http://dx.doi.org/10.1038/ncomms1129DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3060602PMC
November 2010

alpha-secretase mediated conversion of the amyloid precursor protein derived membrane stub C99 to C83 limits Abeta generation.

J Neurochem 2009 Dec;111(6):1369-82

Molecular Neurodegeneration Group, Institute of Physiological Chemistry and Pathobiochemistry, Johannes Gutenberg-University Mainz, Mainz, Germany.

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http://dx.doi.org/10.1111/j.1471-4159.2009.06420.xDOI Listing
December 2009

Induced dimerization of the amyloid precursor protein leads to decreased amyloid-beta protein production.

J Biol Chem 2009 Oct 13;284(42):28943-52. Epub 2009 Jul 13.

Department of Neurosciences, University of California, San Diego, La Jolla, California 92093, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M109.038646
Publisher Site
http://dx.doi.org/10.1074/jbc.M109.038646DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2781440PMC
October 2009

Mechanism of cytotoxicity mediated by the C31 fragment of the amyloid precursor protein.

Biochem Biophys Res Commun 2009 Oct 11;388(2):450-5. Epub 2009 Aug 11.

Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093, USA.

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http://dx.doi.org/10.1016/j.bbrc.2009.08.042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2838490PMC
October 2009

Novel role of RanBP9 in BACE1 processing of amyloid precursor protein and amyloid beta peptide generation.

J Biol Chem 2009 May 27;284(18):11863-72. Epub 2009 Feb 27.

Department of Neurosciences, University of California, San Diego, La Jolla, California 92093, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M807345200
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http://dx.doi.org/10.1074/jbc.M807345200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2673255PMC
May 2009

Amyloid precursor protein trafficking, processing, and function.

J Biol Chem 2008 Oct 23;283(44):29615-9. Epub 2008 Jul 23.

Department of Neurobiology, The University of Chicago, Chicago, Illinois 60637, USA.

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http://dx.doi.org/10.1074/jbc.R800019200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2573065PMC
October 2008

Independent generation of Abeta42 and Abeta38 peptide species by gamma-secretase.

J Biol Chem 2008 Jun 21;283(25):17049-54. Epub 2008 Apr 21.

Molecular Neuropathology Group, Department of Neuropathology, Heinrich Heine-University, D-40225 Duesseldorf, Germany.

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http://dx.doi.org/10.1074/jbc.M802912200DOI Listing
June 2008

Low-density lipoprotein receptor-related protein promotes amyloid precursor protein trafficking to lipid rafts in the endocytic pathway.

FASEB J 2007 Sep 26;21(11):2742-52. Epub 2007 Apr 26.

Department of Neurosciences, UC San Diego, La Jolla, CA 92093, USA.

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http://dx.doi.org/10.1096/fj.07-8114comDOI Listing
September 2007

Rapid, concurrent alterations in pre- and postsynaptic structure induced by naturally-secreted amyloid-beta protein.

Mol Cell Neurosci 2007 Jun 12;35(2):183-93. Epub 2007 Feb 12.

Department of Cell Biology and Institute for Childhood and Neglected Diseases, The Scripps Research Institute, 10550 North Torrey Pines Rd., La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1016/j.mcn.2007.02.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2268524PMC
June 2007

The amyloid precursor protein: beyond amyloid.

Mol Neurodegener 2006 Jul 3;1. Epub 2006 Jul 3.

Huffington Center on Aging and Department of Molecular & Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.

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http://dx.doi.org/10.1186/1750-1326-1-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1538601PMC
July 2006

Inhibitors of Rho-kinase modulate amyloid-beta (Abeta) secretion but lack selectivity for Abeta42.

J Neurochem 2006 Jan 21;96(2):355-65. Epub 2005 Nov 21.

Emmy Noether Research Group, Institute of Physiological Chemistry and Pathobiochemistry, Johannes Gutenberg University Mainz, Mainz, Germany.

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http://dx.doi.org/10.1111/j.1471-4159.2005.03553.xDOI Listing
January 2006

To think or not to think: synaptic activity and Abeta release.

Neuron 2005 Dec;48(6):873-5

Department of Neurosciences, University of California, San Diego, La Jolla, California 92093, USA.

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http://dx.doi.org/10.1016/j.neuron.2005.12.005DOI Listing
December 2005

Presenilins mediate phosphatidylinositol 3-kinase/AKT and ERK activation via select signaling receptors. Selectivity of PS2 in platelet-derived growth factor signaling.

J Biol Chem 2005 Sep 13;280(36):31537-47. Epub 2005 Jul 13.

Department of Neurosciences, University of California, San Diego, La Jolla, California 92093, USA.

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September 2005

Low density lipoprotein receptor-related protein (LRP) interacts with presenilin 1 and is a competitive substrate of the amyloid precursor protein (APP) for gamma-secretase.

J Biol Chem 2005 Jul 25;280(29):27303-9. Epub 2005 May 25.

Alzheimer Research Unit, Massachusetts Institute for Neurodegenerative Disorders, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA.

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http://dx.doi.org/10.1074/jbc.M413969200DOI Listing
July 2005

Perturbed neurogenesis in the adult hippocampus associated with presenilin-1 A246E mutation.

Am J Pathol 2005 Jul;167(1):151-9

Department of Neurosciences, University of California-San Diego, School of Medicine, La Jolla, California 92093-0691, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1603433PMC
http://dx.doi.org/10.1016/S0002-9440(10)62962-8DOI Listing
July 2005

Diverse compounds mimic Alzheimer disease-causing mutations by augmenting Abeta42 production.

Nat Med 2005 May 17;11(5):545-50. Epub 2005 Apr 17.

Department of Neuroscience, Mayo Clinic, Mayo Clinic College of Medicine, 4500 San Pablo Road, Jacksonville, Florida 32224, USA.

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http://www.nature.com/articles/nm1235
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May 2005

The endocytotic pathway is required for increased A beta 42 secretion during apoptosis.

Brain Res Mol Brain Res 2004 Sep;128(2):201-11

Department of Pathology, Northwestern University Feinberg School of Medicine, 303 East Chicago Avenue, Chicago, IL 60611, USA.

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http://dx.doi.org/10.1016/j.molbrainres.2004.06.012DOI Listing
September 2004

Potential role of presenilin-regulated signaling pathways in sporadic neurodegeneration.

Nat Med 2004 Jul;10 Suppl:S26-33

Department of Neurosciences, University of California, San Diego, La Jolla, California 92093, USA.

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http://www.nature.com/doifinder/10.1038/nm1065
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July 2004

Amyloid beta protein toxicity mediated by the formation of amyloid-beta protein precursor complexes.

Ann Neurol 2003 Dec;54(6):781-9

Department of Neurosciences, University of California-San Diego, 9500 Gilman Drive, Mail Code 0691, La Jolla, CA 92093-0691, USA.

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http://dx.doi.org/10.1002/ana.10761DOI Listing
December 2003

Caspase cleavage of the amyloid precursor protein modulates amyloid beta-protein toxicity.

J Neurochem 2003 Nov;87(3):733-41

Department of Neurosciences, University of California, San Diego, La Jolla 92093, USA.

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http://dx.doi.org/10.1046/j.1471-4159.2003.02059.xDOI Listing
November 2003

Abeta42-lowering nonsteroidal anti-inflammatory drugs preserve intramembrane cleavage of the amyloid precursor protein (APP) and ErbB-4 receptor and signaling through the APP intracellular domain.

J Biol Chem 2003 Aug 31;278(33):30748-54. Epub 2003 May 31.

Department of Neurosciences, University of California San Diego, La Jolla, California 92093, USA.

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http://dx.doi.org/10.1074/jbc.M304824200DOI Listing
August 2003

The non-cyclooxygenase targets of non-steroidal anti-inflammatory drugs, lipoxygenases, peroxisome proliferator-activated receptor, inhibitor of kappa B kinase, and NF kappa B, do not reduce amyloid beta 42 production.

J Biol Chem 2003 Aug 12;278(34):31825-30. Epub 2003 Jun 12.

Department of Neurosciences, University of California San Diego, La Jolla, California 921093, USA.

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http://dx.doi.org/10.1074/jbc.M303588200DOI Listing
August 2003

Evidence that nonsteroidal anti-inflammatory drugs decrease amyloid beta 42 production by direct modulation of gamma-secretase activity.

J Biol Chem 2003 Aug 12;278(34):31831-7. Epub 2003 Jun 12.

Department of Neurosciences, University of California San Diego, La Jolla, California 92093, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M303592200
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August 2003

NSAIDs and enantiomers of flurbiprofen target gamma-secretase and lower Abeta 42 in vivo.

J Clin Invest 2003 Aug;112(3):440-9

Department of Neuroscience, Mayo Graduate School, Mayo Clinic Jacksonville, Jacksonville, Florida 32224, USA.

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http://dx.doi.org/10.1172/JCI18162DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC166298PMC
August 2003

Potential link between amyloid beta-protein 42 and C-terminal fragment gamma 49-99 of beta-amyloid precursor protein.

J Biol Chem 2003 Jul 21;278(27):24294-301. Epub 2003 Apr 21.

Department of Neuropathology, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Japan.

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http://dx.doi.org/10.1074/jbc.M211161200DOI Listing
July 2003

The beta-amyloid precursor protein (APP) and Alzheimer's disease: does the tail wag the dog?

Authors:
Edward H Koo

Traffic 2002 Nov;3(11):763-70

Department of Neurosciences, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.

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http://dx.doi.org/10.1034/j.1600-0854.2002.31101.xDOI Listing
November 2002

The cytoplasmic domain of the LDL receptor-related protein regulates multiple steps in APP processing.

EMBO J 2002 Nov;21(21):5691-700

Department of Neurosciences, University of California, San Diego, La Jolla 92093, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC131065PMC
http://dx.doi.org/10.1093/emboj/cdf568DOI Listing
November 2002

Presenilin couples the paired phosphorylation of beta-catenin independent of axin: implications for beta-catenin activation in tumorigenesis.

Cell 2002 Sep;110(6):751-62

Department of Neurosciences, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.

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http://dx.doi.org/10.1016/s0092-8674(02)00970-4DOI Listing
September 2002

Caspase cleavage of members of the amyloid precursor family of proteins.

J Neurochem 2002 Jul;82(2):283-94

Buck Institute for Age Research, Novato, California 94945-1400, USA.

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http://dx.doi.org/10.1046/j.1471-4159.2002.00970.xDOI Listing
July 2002

Exchange of N-CoR corepressor and Tip60 coactivator complexes links gene expression by NF-kappaB and beta-amyloid precursor protein.

Cell 2002 Jul;110(1):55-67

Howard Hughes Medical Institute, Department of Molecular Medicine, La Jolla, CA 92093, USA.

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http://dx.doi.org/10.1016/s0092-8674(02)00809-7DOI Listing
July 2002