Edward D Karoly

Edward D Karoly

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Edward D Karoly

Edward D Karoly

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Ozone-induced changes in the serum metabolome: Role of the microbiome.

PLoS One 2019 27;14(8):e0221633. Epub 2019 Aug 27.

Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0221633PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6711505PMC
August 2019

Changes in Metabolites Present in Lung-Lining Fluid Following Exposure of Humans to Ozone.

Toxicol Sci 2018 06;163(2):430-439

National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina 2799.

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http://dx.doi.org/10.1093/toxsci/kfy043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348881PMC
June 2018

Effect of acute ozone exposure on the lung metabolomes of obese and lean mice.

PLoS One 2017 13;12(7):e0181017. Epub 2017 Jul 13.

Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0181017PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5509247PMC
September 2017

A prospective study of serum metabolites and glioma risk.

Oncotarget 2017 Sep 31;8(41):70366-70377. Epub 2017 Jul 31.

Metabolic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, MD, USA.

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http://dx.doi.org/10.18632/oncotarget.19705DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5642561PMC
September 2017

Prospective serum metabolomic profile of prostate cancer by size and extent of primary tumor.

Oncotarget 2017 Jul;8(28):45190-45199

Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, MD, USA.

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http://dx.doi.org/10.18632/oncotarget.16775DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5542177PMC
July 2017

Replicatively senescent human fibroblasts reveal a distinct intracellular metabolic profile with alterations in NAD+ and nicotinamide metabolism.

Sci Rep 2016 12 7;6:38489. Epub 2016 Dec 7.

Centre for Clinical &Diagnostic Oral Sciences, Institute of Dentistry, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, Turner Street, London, E1 2AD, UK.

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http://dx.doi.org/10.1038/srep38489DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5141431PMC
December 2016

Serum Metabolomic Response to Long-Term Supplementation with --Tocopheryl Acetate in a Randomized Controlled Trial.

J Nutr Metab 2016 20;2016:6158436. Epub 2016 Oct 20.

Department of Health and Human Services, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Nutritional Epidemiology Branch, Bethesda, MD, USA.

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http://dx.doi.org/10.1155/2016/6158436DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5093288PMC
October 2016

Ozone Exposure Increases Circulating Stress Hormones and Lipid Metabolites in Humans.

Am J Respir Crit Care Med 2016 06;193(12):1382-91

2 Environmental Public Health Division, National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina; and.

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http://dx.doi.org/10.1164/rccm.201508-1599OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5440058PMC
June 2016

Metabolomics of dates (Phoenix dactylifera) reveals a highly dynamic ripening process accounting for major variation in fruit composition.

BMC Plant Biol 2015 Dec 16;15:291. Epub 2015 Dec 16.

Department of Physiology and Biophysics, Weill Cornell Medical College, Qatar Foundation - Education City, PO Box 24144, Doha, Qatar.

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http://dx.doi.org/10.1186/s12870-015-0672-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4681049PMC
December 2015

Large-scaled metabolic profiling of human dermal fibroblasts derived from pseudoxanthoma elasticum patients and healthy controls.

PLoS One 2014 29;9(9):e108336. Epub 2014 Sep 29.

Institut für Laboratoriums- und Transfusionsmedizin, Herz- und Diabeteszentrum Nordrhein-Westfalen, Universitätsklinik der Ruhr-Universität Bochum, Bad Oeynhausen, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0108336PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4181624PMC
November 2015

Metabolomic analysis of prostate cancer risk in a prospective cohort: The alpha-tocolpherol, beta-carotene cancer prevention (ATBC) study.

Int J Cancer 2015 Nov 9;137(9):2124-32. Epub 2015 May 9.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD.

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http://dx.doi.org/10.1002/ijc.29576DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4537663PMC
November 2015

Inhaled ozone (O3)-induces changes in serum metabolomic and liver transcriptomic profiles in rats.

Toxicol Appl Pharmacol 2015 Jul 31;286(2):65-79. Epub 2015 Mar 31.

Environmental Public Health Division, National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, NC, USA. Electronic address:

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http://dx.doi.org/10.1016/j.taap.2015.03.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4765366PMC
July 2015

Metabolic signatures differentiate ovarian from colon cancer cell lines.

J Transl Med 2015 Jul 14;13:223. Epub 2015 Jul 14.

Stem Cell and Microenvironment Laboratory, Weill Cornell Medical College in Qatar, Education City, Qatar Foundation, Doha, Qatar.

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http://dx.doi.org/10.1186/s12967-015-0576-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4499939PMC
July 2015

PD-1 alters T-cell metabolic reprogramming by inhibiting glycolysis and promoting lipolysis and fatty acid oxidation.

Nat Commun 2015 Mar 26;6:6692. Epub 2015 Mar 26.

1] Division of Hematology-Oncology, Harvard Medical School, 330 Brookline Avenue, Boston, Massachusetts 02215, USA [2] Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, Massachusetts 02215, USA [3] Beth Israel Deaconess Cancer Center, Harvard Medical School, 330 Brookline Avenue, Boston, Massachusetts 02215, USA.

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http://dx.doi.org/10.1038/ncomms7692DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4389235PMC
March 2015

Inactivation of metabolic genes causes short- and long-range dys-regulation in Escherichia coli metabolic network.

PLoS One 2013 5;8(12):e78360. Epub 2013 Dec 5.

Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0078360PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3868466PMC
July 2014

Uremic solutes and risk of end-stage renal disease in type 2 diabetes: metabolomic study.

Kidney Int 2014 May 15;85(5):1214-24. Epub 2014 Jan 15.

1] Section on Genetics and Epidemiology, Research Division, Joslin Diabetes Center, Boston, Massachussetts, USA [2] Department of Medicine, Harvard Medical School, Boston, Massachussetts, USA.

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http://dx.doi.org/10.1038/ki.2013.497DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4072128PMC
May 2014

1,5-Anhydroglucitol in saliva is a noninvasive marker of short-term glycemic control.

J Clin Endocrinol Metab 2014 Mar 1;99(3):E479-83. Epub 2014 Jan 1.

Department of Physiology and Biophysics (D.O.M.-K., J.R., N.A.Y., M.J.M.-K., W.A.A.M., K.S.) and Clinical Research Core (W.S.G., O.M.C., M.J.M.-K., S.A.K., C.M.), Weill Cornell Medical College, Qatar, Doha, Qatar; Department of Endocrinology (D.O.M.-K.), Leiden University Medical Centre, 2300 RC Leiden, The Netherlands; Departments of Dermatology (M.M.E.D.S., A.H.T., H.A.-H., K.A.S.A.-M., A.A.-O.) and Endocrinology (M.A.Z.), Hamad Medical Corporation, Doha, Qatar; Metabolon Inc (E.D.K.), Durham, North Carolina 27713; Unit of Periodontology (T.K.), Department of Restorative Dentistry, Periodontology, and Endodontology, University Medicine Greifswald, D-17487 Greifswald, Germany; and Institute of Bioinformatics and Systems Biology (K.S.), Helmholtz Zentrum München, German Research Center for Environmental Health, 85764 Neuherberg, Germany.

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http://dx.doi.org/10.1210/jc.2013-3596DOI Listing
March 2014

The human ΔNp53 isoform triggers metabolic and gene expression changes that activate mTOR and alter mitochondrial function.

Aging Cell 2013 Oct 25;12(5):863-72. Epub 2013 Jun 25.

Department of Chemistry and Biochemistry, University of Colorado, Boulder, CO 80303, USA.

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http://dx.doi.org/10.1111/acel.12108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3773055PMC
October 2013

Metabolomic profile of response to supplementation with β-carotene in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study.

Am J Clin Nutr 2013 Aug 26;98(2):488-93. Epub 2013 Jun 26.

Nutritional Epidemiology Branch and the Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, MD, USA.

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http://dx.doi.org/10.3945/ajcn.113.062778DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3712556PMC
August 2013

Licofelone modulates neuroinflammation and attenuates mechanical hypersensitivity in the chronic phase of spinal cord injury.

J Neurosci 2013 Jan;33(2):652-64

Department of Integrative Biology and Pharmacology, The University of Texas Medical School at Houston, Texas, 77030, USA.

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http://dx.doi.org/10.1523/JNEUROSCI.6128-11.2013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3586230PMC
January 2013

Prospective study of changes in the metabolomic profiles of men during their first three months of androgen deprivation therapy for prostate cancer.

Clin Cancer Res 2012 Jul 15;18(13):3677-85. Epub 2012 May 15.

Division of Hematology-Oncology, Massachusetts General Hospital (MGH) Cancer Center, Boston, Massachusetts 02114, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-11-3209DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3661207PMC
July 2012

Oncogene-induced senescence results in marked metabolic and bioenergetic alterations.

Cell Cycle 2012 Apr 1;11(7):1383-92. Epub 2012 Apr 1.

Center for Molecular Medicine, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.4161/cc.19800DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3350879PMC
April 2012

Comparison of gene expression profiles induced by coarse, fine, and ultrafine particulate matter.

J Toxicol Environ Health A 2011 ;74(5):296-312

Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA.

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http://dx.doi.org/10.1080/15287394.2010.516238DOI Listing
February 2011

Profiling the effects of isocitrate dehydrogenase 1 and 2 mutations on the cellular metabolome.

Proc Natl Acad Sci U S A 2011 Feb 2;108(8):3270-5. Epub 2011 Feb 2.

The Preston Robert Tisch Brain Tumor Center at Duke, Pediatric Brain Tumor Foundation Institute, Duke University Medical Center, Durham, NC 27710, USA.

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http://dx.doi.org/10.1073/pnas.1019393108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3044380PMC
February 2011

Metabolomic differences in heart failure patients with and without major depression.

J Geriatr Psychiatry Neurol 2010 Jun 25;23(2):138-46. Epub 2010 Jan 25.

Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA.

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http://dx.doi.org/10.1177/0891988709358592DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3279728PMC
June 2010

Metabolomics for early detection of drug-induced kidney injury: review of the current status.

Bioanalysis 2009 Dec;1(9):1645-63

Metabolon Inc., 800 Capitola Drive, Suite 1, Durham, NC 27713, USA.

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http://dx.doi.org/10.4155/bio.09.142DOI Listing
December 2009

One-month diesel exhaust inhalation produces hypertensive gene expression pattern in healthy rats.

Environ Health Perspect 2009 Jan 12;117(1):38-46. Epub 2008 Sep 12.

Experimental Toxicology Division, National Health & Environmental Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, USA.

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http://dx.doi.org/10.1289/ehp.11647DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2627863PMC
January 2009

The role of particulate matter-associated zinc in cardiac injury in rats.

Environ Health Perspect 2008 Jan;116(1):13-20

National Health and Environmental Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, NC 27710, USA.

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http://dx.doi.org/10.1289/ehp.10379DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2199289PMC
January 2008

Assessing the role of particulate matter size and composition on gene expression in pulmonary cells.

Inhal Toxicol 2007 ;19 Suppl 1:23-8

MDS Pharma Services, Inc., Lincoln, Nebraska 68521, USA.

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http://dx.doi.org/10.1080/08958370701490551DOI Listing
November 2007

Up-regulation of tissue factor in human pulmonary artery endothelial cells after ultrafine particle exposure.

Environ Health Perspect 2007 Apr 8;115(4):535-40. Epub 2007 Jan 8.

National Health and Environmental Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, NC 27711, USA.

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https://ehp.niehs.nih.gov/doi/10.1289/ehp.9556
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http://dx.doi.org/10.1289/ehp.9556DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1852686PMC
April 2007

Ontogeny of transcription profiles during mouse early craniofacial development.

Reprod Toxicol 2005 Jan-Feb;19(3):339-52

Curriculum in Toxicology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.1016/j.reprotox.2004.09.008DOI Listing
June 2005

In vitro sulfoxidation of thioether compounds by human cytochrome P450 and flavin-containing monooxygenase isoforms with particular reference to the CYP2C subfamily.

Drug Metab Dispos 2004 Mar;32(3):333-9

Department of Environmental and Molecular Toxicology, North Carolina State University, Raleigh, North Carolina 27695, USA.

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http://dx.doi.org/10.1124/dmd.32.3.333DOI Listing
March 2004