Edward C Keystone

Edward C Keystone

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MRI and Dose Selection in a Phase II Trial of Baricitinib with Conventional Synthetic Disease-modifying Antirheumatic Drugs in Rheumatoid Arthritis.

J Rheumatol 2019 Aug 15;46(8):887-895. Epub 2019 Jan 15.

From Spire Sciences Inc., Boca Raton, Florida; Division of Immunology and Rheumatology, Stanford University, Stanford, California; Eli Lilly and Co., Indianapolis, Indiana; Incyte Corporation, Wilmington, Delaware, USA; The Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds; Botnar Research Centre, University of Oxford, Oxford, UK; Department of Rheumatology, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.3899/jrheum.171469DOI Listing
August 2019

Comprehensive Profiling of Rheumatoid Arthritis Antibody Repertoire.

Arthritis Rheumatol 2019 Aug 26. Epub 2019 Aug 26.

Departments of Medicine and Immunology, University of Toronto, Mount Sinai and Toronto General Research Institutes, Toronto, Canada.

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http://dx.doi.org/10.1002/art.41089DOI Listing
August 2019

Overweight, Obesity, and the Likelihood of Achieving Sustained Remission in Early Rheumatoid Arthritis: Results From a Multicenter Prospective Cohort Study.

Arthritis Care Res (Hoboken) 2018 08 13;70(8):1185-1191. Epub 2018 Jul 13.

Hospital for Special Surgery, Weill Cornell Medical College, New York, New York, and Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/acr.23457DOI Listing
August 2018

The Dorsal 4-finger Technique: A Novel Method to Examine Metacarpophalangeal Joints in Patients with Rheumatoid Arthritis.

J Rheumatol 2018 03 15;45(3):329-334. Epub 2018 Jan 15.

From the Division of Rheumatology, Department of Medicine, College of Medicine, King Saud University, Riyadh, Saudi Arabia; Division of Rheumatology, Department of Medicine, and Division of Musculoskeletal Imaging, Department of Medical Imaging, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.3899/jrheum.161507DOI Listing
March 2018

Corrigendum to "Klinefelter's syndrome (47,XXY) is in excess among men with Sjögren's syndrome" [Clin. Immunol. 168 (2016) 25-29].

Clin Immunol 2018 02 7;187:137-138. Epub 2017 Dec 7.

Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA; Department of Pathology, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA; Department of Medicine, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA; Medical Service, Department of Veterans Affairs Medical Center, Oklahoma City, OK, USA. Electronic address:

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http://dx.doi.org/10.1016/j.clim.2017.11.012DOI Listing
February 2018

Safety and Efficacy of Baricitinib Through 128 Weeks in an Open-label, Longterm Extension Study in Patients with Rheumatoid Arthritis.

J Rheumatol 2018 01 15;45(1):14-21. Epub 2017 Aug 15.

Kennedy Institute of Rheumatology and Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.3899/jrheum.161161DOI Listing
January 2018

Triple Therapy Versus Biologic Therapy for Active Rheumatoid Arthritis: A Cost-Effectiveness Analysis.

Ann Intern Med 2017 Jul 30;167(1):8-16. Epub 2017 May 30.

From University of British Columbia and St Paul's Hospital, Vancouver, British Columbia, Canada; Palo Alto Veterans Affairs (VA) Health Care System, Palo Alto, and Stanford University School of Medicine, Stanford, California; VA Nebraska-Western Iowa Health Care Center and University of Nebraska Medical Center, Omaha, Nebraska; Boston University School of Medicine, Boston, Massachusetts; and University of Toronto and Mount Sinai Hospital, Toronto, Ontario, Canada.

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http://dx.doi.org/10.7326/M16-0713DOI Listing
July 2017

Baricitinib versus Placebo or Adalimumab in Rheumatoid Arthritis.

N Engl J Med 2017 02;376(7):652-662

From the Nuffield Department of Orthopaedics, Rheumatology, and Musculoskeletal Sciences and the Kennedy Institute of Rheumatology, University of Oxford, Oxford, United Kingdom (P.C.T.); the Rebecca MacDonald Centre, Mount Sinai Hospital, University of Toronto, Toronto (E.C.K.); Leiden University Medical Center, Leiden, the Netherlands (D.H.); Brigham and Women's Hospital, Boston (M.E.W.); Instituto Reumatológico Strusberg, Córdoba, Argentina (L.C.M.); Centro de Investigacion Clinica Especializada, Mexico City (J.R.G.); Ryazan Regional Clinical Cardiology Dispensary, Ryazan, Russia (S.Y.); Eli Lilly, Indianapolis (T.I., S. Beattie, V.A., C.G., T.R., D.S., W.L.M., S. de Bono); and AstraZeneca K.K., Osaka (K.E.), and the First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu (Y.T.) - both in Japan.

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http://dx.doi.org/10.1056/NEJMoa1608345DOI Listing
February 2017

Klinefelter's syndrome (47,XXY) is in excess among men with Sjögren's syndrome.

Clin Immunol 2016 07 22;168:25-29. Epub 2016 Apr 22.

Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA; Department of Pathology, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA; Department of Medicine, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA; Medical Service, Department of Veterans Affairs Medical Center, Oklahoma City, OK, USA. Electronic address:

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http://dx.doi.org/10.1016/j.clim.2016.04.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4940221PMC
July 2016

The comparative effectiveness of oral versus subcutaneous methotrexate for the treatment of early rheumatoid arthritis.

Ann Rheum Dis 2016 Jun 15;75(6):1003-8. Epub 2015 May 15.

Mount Sinai Hospital, Toronto, Ontario, Canada Hospital for Special Surgery, New York, New York, USA.

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http://dx.doi.org/10.1136/annrheumdis-2014-206504DOI Listing
June 2016

Identifying flares in rheumatoid arthritis: reliability and construct validation of the OMERACT RA Flare Core Domain Set.

RMD Open 2016 26;2(1):e000225. Epub 2016 May 26.

Division of Rheumatology, Johns Hopkins School of Medicine, Baltimore, Maryland, USA; Divisions of Clinical Epidemiology, Rheumatology, and Respiratory Clinical Trials Unit, McGill University, Montreal, Québec, Canada.

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http://dx.doi.org/10.1136/rmdopen-2015-000225DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4885442PMC
June 2016

Heterogeneous Disease Trajectories Explain Variable Radiographic, Function and Quality of Life Outcomes in the Canadian Early Arthritis Cohort (CATCH).

PLoS One 2015 24;10(8):e0135327. Epub 2015 Aug 24.

Division of Rheumatology, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada; Hospital for Special Surgery, Weill Cornell Medical College, New York, New York, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0135327PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4547697PMC
May 2016

X Chromosome Dose and Sex Bias in Autoimmune Diseases: Increased Prevalence of 47,XXX in Systemic Lupus Erythematosus and Sjögren's Syndrome.

Arthritis Rheumatol 2016 05;68(5):1290-1300

College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.

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http://dx.doi.org/10.1002/art.39560DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5019501PMC
May 2016

Fibrocyte and T cell interactions promote disease pathogenesis in rheumatoid arthritis.

J Autoimmun 2016 May 3;69:38-50. Epub 2016 Mar 3.

Toronto General Research Institute, University Health Network, Toronto, Canada; Department of Immunology, University of Toronto, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jaut.2016.02.008DOI Listing
May 2016

Certolizumab Pegol Efficacy Across Methotrexate Regimens: A Pre-Specified Analysis of Two Phase III Trials.

Arthritis Care Res (Hoboken) 2016 Mar;68(3):299-307

Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, and National Institute for Health Research Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospitals National Health Service Trust, Leeds, UK.

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http://doi.wiley.com/10.1002/acr.22676
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http://dx.doi.org/10.1002/acr.22676DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5067694PMC
March 2016

Safety and Efficacy of Subcutaneous Golimumab in Patients with Active Rheumatoid Arthritis despite Methotrexate Therapy: Final 5-year Results of the GO-FORWARD Trial.

J Rheumatol 2016 Feb 15;43(2):298-306. Epub 2015 Dec 15.

From Immunology and Rheumatology, University of Toronto and Mount Sinai Hospital, Toronto, Ontario, Canada; Immunology and Rheumatology, Stanford University, Palo Alto, California; Janssen Global Services LLC, Malvern, Pennsylvania, USA; Biostatistics, Janssen Research & Development LLC, Malvern; Biologics Clinical Pharmacology, and Immunology, Janssen Research & Development LLC, Spring House, Pennsylvania, USA; Rheumatology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA; Rheumatology, Cabrini Medical Centre, Malvern, Australia; Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, Korea.E.C. Keystone, MD, FRCP(C), Immunology and Rheumatology, University of Toronto and Mount Sinai Hospital; M.C. Genovese, MD, Immunology and Rheumatology, Stanford University; S. Hall, MBBS, FRACP, Rheumatology, Cabrini Medical Centre; S.C. Bae, MD, PhD, MPH, Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases; C. Han, PhD, Janssen Global Services LLC; T.A. Gathany, MEd, Janssen Global Services LLC; S. Xu, MS, Biostatistics, Janssen Research & Development LLC; Y. Zhou, PhD, Biostatistics, Janssen Research & Development LLC; J.H. Leu, PhD, Biologics Clinical Pharmacology, Janssen Research & Development LLC; E.C. Hsia, MD, Immunology, Janssen Research & Development LLC, and Rheumatology, University of Pennsylvania School of Medicine.

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http://dx.doi.org/10.3899/jrheum.150712DOI Listing
February 2016

Attitudes towards subsequent entry biologics/biosimilars: A survey of Canadian rheumatologists.

Clin Rheumatol 2015 Aug 15;34(8):1427-33. Epub 2015 Jan 15.

Institute of Management & Innovation, University of Toronto Mississauga, 3359 Mississauga Road, Mississauga, ON, L5L 1C6, Canada.

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http://dx.doi.org/10.1007/s10067-014-2835-4DOI Listing
August 2015

Does socioeconomic status affect outcomes in early inflammatory arthritis? Data from a canadian multisite suspected rheumatoid arthritis inception cohort.

J Rheumatol 2015 Jan 15;42(1):46-54. Epub 2014 Nov 15.

From the Schulich School of Medicine and Dentistry, Department of Internal Medicine, University of Western Ontario, London, Ontario, Canada; Rheumatology, Hospital for Special Surgery, Cornell University, New York, New York, USA; Rheumatology Division, Université de Sherbrooke, Sherbrooke, Quebec; Arthritis Centre, University of Manitoba, Winnipeg, Manitoba; Southlake Regional Health Centre, Newmarket, Ontario; Rheumatic Disease Unit, Institut de Rhumatologie, Montreal, Quebec; Rheumatology, Mount Sinai Hospital, University of Toronto, Toronto; Rheumatology, St. Joseph's Health Care, London, Ontario, Canada.G. Yang, MD, Schulich School of Medicine and Dentistry, Department of Internal Medicine, University of Western Ontario; V.P. Bykerk, MD, FRCPC, Rheumatology, Hospital for Special Surgery, Cornell University; G. Boire, MD, FRCPC, Rheumatology Division, Universite de Sherbrooke; C.A. Hitchon, MD, FRCPC, Arthritis Centre, University of Manitoba; J.C. Thorne, MD, FRCPC; D. Tin, BSc Pharm, Southlake Regional Health Centre; B. Haraoui, MD, FRCPC, Rheumatic Disease Unit, Institut de Rhumatologie; E.C. Keystone, MD, FRCPC, Rheumatology, Mount Sinai Hospital, University of Toronto; J.E. Pope, MD, FRCPC, MPH, Schulich School of Medicine and Dentistry, Department of Internal Medicine, University of Western Ontario, and Rheumatology, St. Joseph's Health Care.

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http://dx.doi.org/10.3899/jrheum.131382DOI Listing
January 2015

Arthritis clinical trials at a crossroad.

J Rheumatol 2015 Jan;42(1):14-7

Canadian Rheumatology Research Consortium, Toronto, Ontario, Canada.

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http://dx.doi.org/10.3899/jrheum.140717DOI Listing
January 2015

The Canadian methotrexate and etanercept outcome study: a randomised trial of discontinuing versus continuing methotrexate after 6 months of etanercept and methotrexate therapy in rheumatoid arthritis.

Ann Rheum Dis 2014 Dec 26;73(12):2144-51. Epub 2013 Aug 26.

Department of Rheumatology, Mount Sinai Hospital, Rebecca MacDonald Centre For Arthritis & Autoimmune Diseases, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1136/annrheumdis-2013-203684DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4251190PMC
December 2014

Prognosis of seronegative patients in a large prospective cohort of patients with early inflammatory arthritis.

J Rheumatol 2014 Dec 1;41(12):2361-9. Epub 2014 Oct 1.

From the Department of Medicine, Division of Rheumatology, St. Joseph's Health Care London, University of Western Ontario, London; Rebecca McDonald Center for Arthritis and Autoimmune Disease, Mount Sinai Hospital, University of Toronto, Toronto; Southlake Regional Health Centre, Newmarket, Ontario; Rheumatology Division, Université de Sherbrooke, Sherbrooke; Rheumatic Disease Unit, Institut de Rheumatologie, Université de Montréal, Montreal, Quebec; Arthritis Center, University of Manitoba, Winnipeg, Manitoba, Canada; Inflammatory Arthritis Center, Hospital for Special Surgery, Department of Biostatistics, Harvard University, Boston, Massachusetts; Weill Cornell Medical College, Cornell University, New York, New York, USA.Dr. Barra has received honoraria from Hoffmann-La Roche Ltd., Amgen Canada Inc., AbbVie, and United Chemicals of Belgium (UCB). The CATCH study was designed and implemented by the investigators and financially supported initially by Amgen Canada Inc. and Pfizer Canada Inc. through an unrestricted research grant since inception of CATCH. As of 2011, further support was provided by Hoffmann-La Roche Ltd., UCB Canada Inc., Bristol-Myers Squibb Canada Co., Abbott Laboratories Ltd., and Janssen Biotech Inc. (a wholly owned subsidiary of Johnson & Johnson Inc.).L. Barra, MD, MPH; J.E. Pope, MD, MPH, Department of Medicine, Division of Rheumatology, St. Joseph's Health Care London, University of Western Ontario; J.E. Orav, PhD, Department of Biostatistics, Harvard University; G. Boire, MD, MSc, Rheumatology Division, Université de Sherbrooke; B. Haraoui, MD, Rheumatic Disease Unit, Institut de Rheumatologie, Université de Montréal; C. Hitchon, MD, MSc, Arthritis Center, University of Manitoba; E.C. Keystone, MD, Rebecca McDonald Center for Arthritis and Autoimmune Disease, Mount Sinai Hospital, University of Toronto; J.C. Thorne, MD; D. Tin, BPharm, Southlake Regional Health Centre; V.P. Bykerk, MD, Rebecca McDonald Center for Arthritis and Autoimm

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http://www.jrheum.org/content/41/12/2361.full.pdf
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http://www.jrheum.org/cgi/doi/10.3899/jrheum.140082
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http://dx.doi.org/10.3899/jrheum.140082DOI Listing
December 2014

Serum 14-3-3η is a novel marker that complements current serological measurements to enhance detection of patients with rheumatoid arthritis.

J Rheumatol 2014 Nov 15;41(11):2104-13. Epub 2014 Aug 15.

From the University of Alberta, Edmonton, Alberta; Augurex Life Sciences Corp., North Vancouver, British Columbia; Mount Sinai Hospital, Toronto, Ontario, Canada; Quest Diagnostics Nichols Institute, San Juan Capistrano; Stanford University Medical Center, Palo Alto, California; Hospital for Special Surgery, New York, New York; Brigham and Women's Hospital, Boston, Massachusetts, USA; Vrije Universiteit University Medical Center; Academic Medical Center/University of Amsterdam; Jan van Breemen Research Institute, Reade organization, Amsterdam; the Department of Rheumatology, Leiden University Medical Center, Leiden, the Netherlands; University of Cambridge, Cambridge; GlaxoSmithKline, Stevenage, UK.W.P. Maksymowych, MD, Professor of Medicine, University of Alberta; S.J. Naides, MD, Quest Diagnostics Nichols Institute; V. Bykerk, MD, Hospital for Special Surgery; K.A. Siminovitch, MD, Mount Sinai Hospital; D. van Schaardenburg, MD, Jan van Breemen Research Institute; M. Boers, MD, Vrije Universiteit University Medical Center; R. Landewé, MD, Academic Medical Center/University of Amsterdam; D. van der Heijde, MD, Department of Rheumatology, Leiden University Medical Center; P-P. Tak, MD, Academic Medical Center/University of Amsterdam, University of Cambridge, GlaxoSmithKline; M.C. Genovese, MD, Stanford University Medical Center; M.E. Weinblatt, MD, Brigham and Women's Hospital; E.C. Keystone, MD, Mount Sinai Hospital; O.S. Zhukov, MS; R.W. Abolhosn, BS; J.M. Popov, MD, PhD, Quest Diagnostics Nichols Institute; K. Britsemmer, MD, Jan van Breemen Research Institute; A.W. van Kuijk, MD, Academic Medical Center/University of Amsterdam; A. Marotta, PhD, Augurex Life Sciences Corp.

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http://dx.doi.org/10.3899/jrheum.131446DOI Listing
November 2014

A phase III, multicenter, randomized, double-blind, placebo-controlled, parallel-group study of 2 dosing regimens of fostamatinib in patients with rheumatoid arthritis with an inadequate response to a tumor necrosis factor-α antagonist.

J Rheumatol 2014 Nov 15;41(11):2120-8. Epub 2014 Sep 15.

From Stanford University, Palo Alto, California, USA; Leiden University Medical Center, Leiden, The Netherlands; University of Toronto, Toronto, Ontario, Canada; Centro Medico Privado de Reumatologia, San Miguel de Tucuman, Argentina; Centre Hospitalier Régional, Orleans, France; University of California, San Diego, La Jolla, California; Austin Rheumatology Research PA, Austin, Texas; (formerly) AstraZeneca, Wilmington, Delaware, USA; AstraZeneca, Macclesfield, UK; Arthritis Associates, Orlando, Florida; Brigham and Women's Hospital, Boston, Massachusetts, USA.M.C. Genovese, MD, Stanford University; D.M. van der Heijde, MD, PhD, Leiden University Medical Center; E.C. Keystone, MD, University of Toronto; A.J. Spindler, MD, Centro Medico Privado de Reumatologia; C. Benhamou, MD, Centre Hospitalier Régional; A. Kavanaugh, MD, University of California, San Diego; E. Fudman, MD, Austin Rheumatology Research PA; K. Lampl, MD; C. O'Brien, MD, PhD, (formerly) AstraZeneca; E.L. Duffield, MSc, AstraZeneca, UK; J. Poiley, MD, Arthritis Associates; M.E. Weinblatt, MD, Brigham and Women's Hospital.

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http://dx.doi.org/10.3899/jrheum.140238DOI Listing
November 2014

Earlier time to remission predicts sustained clinical remission in early rheumatoid arthritis--results from the Canadian Early Arthritis Cohort (CATCH).

J Rheumatol 2014 Nov 1;41(11):2161-6. Epub 2014 Oct 1.

From the Rheumatology Department, Mount Sinai Hospital, University of Toronto, Toronto, Ontario; Université de Sherbrooke, Sherbrooke; Rheumatic Disease Unit, Institut de Rhumatologie, Montreal, Quebec; Arthritis Centre, University of Manitoba, Winnipeg, Manitoba; Rheumatology Department, St. Joseph's Health Care, Western University, London; Southlake Regional Health Centre, Newmarket, Ontario, Canada; Hospital for Special Surgery, Cornell University, New York, New York, USA.B. Kuriya, MD, MS, FRCPC; J. Xiong, MSc, PhD, Rheumatology Department, Mount Sinai Hospital, University of Toronto; G. Boire, MD, MSc, FRCPC, Université de Sherbrooke; B. Haraoui, MD, FRCPC, Rheumatic Disease Unit, Institut de Rhumatologie; C. Hitchon, MD, MSc, FRCPC, Arthritis Centre, University of Manitoba; J. Pope, MD, MPH, FRCPC, Rheumatology Department, St. Joseph's Health Care, Western University; J.C. Thorne, MD, FRCP, FACP; D. Tin, BSc PHm, RPh, CDE, CGP, Southlake Regional Health Centre; E.C. Keystone, MD, FRCPC, Rheumatology Department, Mount Sinai Hospital, University of Toronto; V. Bykerk, MD, FRCPC, Rheumatology Department, Mount Sinai Hospital, University of Toronto, and Hospital for Special Surgery, Cornell University.

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http://dx.doi.org/10.3899/jrheum.140137DOI Listing
November 2014

Is structural damage evaluation by traditional radiographs still relevant in rheumatoid arthritis clinical trials?

J Rheumatol 2014 Nov;41(11):2325

Professor of Medicine, University of Toronto, Director, Rebecca MacDonald Centre for Arthritis and Autoimmune Diseases, Mount Sinai Hospital, Toronto, Ontario, Canada.

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http://dx.doi.org/10.3899/jrheum.140383DOI Listing
November 2014

Therapy: oral or subcutaneous methotrexate for rheumatoid arthritis?

Nat Rev Rheumatol 2014 Oct 5;10(10):578-9. Epub 2014 Aug 5.

Mount Sinai Hospital, 60 Murray Street, Room 2-006, Toronto, ON M5T 3L9, Canada.

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http://dx.doi.org/10.1038/nrrheum.2014.129DOI Listing
October 2014

Intravenous golimumab in rheumatoid arthritis.

Expert Rev Clin Immunol 2014 Jul 15;10(7):823-30. Epub 2014 May 15.

Mayo Clinic, 668 Humboldt St, Denver, CO 80218, USA.

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http://dx.doi.org/10.1586/1744666X.2014.918847DOI Listing
July 2014

Remission in rheumatoid arthritis patients treated with etanercept monotherapy: clinical practice and clinical trial experience.

Clin Exp Rheumatol 2013 Nov-Dec;31(6):919-25. Epub 2013 Nov 14.

Veterans Affairs Medical Center and University of Utah, Salt Lake City University of Utah, Salt Lake City, UT, USA.

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March 2014

Physician global assessment at 3 months is strongly predictive of remission at 12 months in early rheumatoid arthritis: results from the CATCH cohort.

Rheumatology (Oxford) 2014 Mar 15;53(3):482-90. Epub 2013 Nov 15.

Department of Rheumatology, St Joseph's Health Care, 268 Grosvenor St., London, ON, N6A 4V2, Canada.

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http://dx.doi.org/10.1093/rheumatology/ket366DOI Listing
March 2014

Clinical, functional, and radiographic implications of time to treatment response in patients with early rheumatoid arthritis: a posthoc analysis of the PREMIER study.

J Rheumatol 2014 Feb 1;41(2):235-43. Epub 2013 Dec 1.

From the University of Toronto, Toronto, Ontario; the University of Montreal, Montreal, Quebec, Canada; AbbVie Inc., North Chicago, Illinois; and the University of California San Diego, La Jolla, California, USA.

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http://dx.doi.org/10.3899/jrheum.121468DOI Listing
February 2014

Continued benefit of tocilizumab plus disease-modifying antirheumatic drug therapy in patients with rheumatoid arthritis and inadequate clinical responses by week 8 of treatment.

J Rheumatol 2014 Feb 15;41(2):216-26. Epub 2014 Jan 15.

From Mount Sinai Hospital, The Rebecca MacDonald Centre for Arthritis and Autoimmune Disease, Toronto, Ontario, Canada; US Medical Affairs-Immunology and Biometrics and Health Outcomes, Genentech, South San Francisco, California; University of Alabama at Birmingham, Division of Clinical Immunology and Rheumatology, Birmingham, Alabama, USA.

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http://dx.doi.org/10.3899/jrheum.130489DOI Listing
February 2014

Factors associated with time to diagnosis in early rheumatoid arthritis.

Rheumatol Int 2014 Jan 30;34(1):85-92. Epub 2013 Aug 30.

Departments of Medicine and Community Health Sciences, University of Calgary, 3330 Hospital Dr NW, Calgary, AB, T2N 4N1, Canada,

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http://dx.doi.org/10.1007/s00296-013-2846-5DOI Listing
January 2014

Longterm effect of delaying combination therapy with tumor necrosis factor inhibitor in patients with aggressive early rheumatoid arthritis: 10-year efficacy and safety of adalimumab from the randomized controlled PREMIER trial with open-label extension.

J Rheumatol 2014 Jan 15;41(1):5-14. Epub 2013 Nov 15.

From the University of Toronto, Toronto, Ontario, Canada; Leiden University Medical Center, Leiden, The Netherlands; Academic Medical Center, Amsterdam, The Netherlands; AbbVie, Rungis, France; AbbVie Inc., North Chicago, Illinois, USA; AbbVie Deutschland GmbH and Co KG, Ludwigshafen, Germany; University of California San Diego, La Jolla, California, USA.

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http://dx.doi.org/10.3899/jrheum.130543DOI Listing
January 2014

Achieving remission in clinical practice: lessons from clinical trial data.

Clin Exp Rheumatol 2013 Jul-Aug;31(4):621-32. Epub 2013 Apr 22.

Hospital for Special Surgery, New York City, USA.

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October 2013

Anticitrullinated protein antibodies and rheumatoid factor fluctuate in early inflammatory arthritis and do not predict clinical outcomes.

J Rheumatol 2013 Aug 1;40(8):1259-67. Epub 2013 Feb 1.

Department of Medicine, Division of Rheumatology, St. Joseph's Health Care London, University of Western Ontario, London, Ontario, Canada.

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http://dx.doi.org/10.3899/jrheum.120736DOI Listing
August 2013

Golimumab in patients with active rheumatoid arthritis despite methotrexate therapy: results through 2 years of the GO-FORWARD study extension.

J Rheumatol 2013 Jul 15;40(7):1097-103. Epub 2013 May 15.

Immunology department, University of Toronto and Mount Sinai Hospital, Toronto, Ontario, Canada.

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http://dx.doi.org/10.3899/jrheum.120584DOI Listing
July 2013

Rational therapy in RA: Issues in implementing a treat-to-target approach in RA.

Nat Rev Rheumatol 2013 Mar 12;9(3):137-8. Epub 2013 Feb 12.

University of Colorado Medical Center, Division of Rheumatology, 668 Humboldt St Denver, CO 80218, USA.

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http://dx.doi.org/10.1038/nrrheum.2013.18DOI Listing
March 2013

Risk of failure of a clinical drug trial in patients with moderate to severe rheumatoid arthritis.

J Rheumatol 2012 Nov 1;39(11):2066-70. Epub 2012 Sep 1.

University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.3899/jrheum.120005DOI Listing
November 2012

Increasing treatment in early rheumatoid arthritis is not determined by the disease activity score but by physician global assessment: results from the CATCH study.

J Rheumatol 2012 Nov 1;39(11):2081-7. Epub 2012 Sep 1.

Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada.

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http://dx.doi.org/10.3899/jrheum.120520DOI Listing
November 2012

Clinical evaluation of the efficacy of the P2X7 purinergic receptor antagonist AZD9056 on the signs and symptoms of rheumatoid arthritis in patients with active disease despite treatment with methotrexate or sulphasalazine.

Ann Rheum Dis 2012 Oct;71(10):1630-5

The Rebecca MacDonald Centre For Arthritis & Autoimmune Diseases, Mount Sinai Hospital, 60 Murray St, Box 4, Toronto, ON, Canada M5T 3L9.

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http://dx.doi.org/10.1136/annrheumdis-2011-143578DOI Listing
October 2012

Rheumatoid arthritis: where are we now?

Rheumatology (Oxford) 2012 Jul;51 Suppl 5:v1-2

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http://dx.doi.org/10.1093/rheumatology/kes112DOI Listing
July 2012

Developing an effective treatment algorithm for rheumatoid arthritis.

Rheumatology (Oxford) 2012 Jul;51 Suppl 5:v48-54

University of Toronto, Department of Immunology, Toronto, ON, Canada.

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http://dx.doi.org/10.1093/rheumatology/kes122DOI Listing
July 2012

Future of RA: building on what we know and tailoring treatment.

Rheumatology (Oxford) 2012 Jul;51 Suppl 5:v55-6

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http://dx.doi.org/10.1093/rheumatology/kes121DOI Listing
July 2012

Remission in early rheumatoid arthritis -- a comparison of new ACR/EULAR remission criteria to established criteria.

J Rheumatol 2012 Jun 15;39(6):1155-8. Epub 2012 Apr 15.

Division of Rheumatology, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.3899/jrheum.111341DOI Listing
June 2012

TNFα modulates protein degradation pathways in rheumatoid arthritis synovial fibroblasts.

Arthritis Res Ther 2012 Mar 14;14(2):R62. Epub 2012 Mar 14.

Arthritis and Immune Disorder Research Centre, University Health Network, Toronto Medical Discovery Tower, 10th Floor, Room 10-358, 101 College Street, Toronto, Ontario M5G 1L7, Canada.

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http://dx.doi.org/10.1186/ar3778DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3446430PMC
March 2012

Assessment by MRI of inflammation and damage in rheumatoid arthritis patients with methotrexate inadequate response receiving golimumab: results of the GO-FORWARD trial.

Ann Rheum Dis 2011 Nov 21;70(11):1968-74. Epub 2011 Jul 21.

Section of Musculoskeletal Disease, Leeds Institute of Molecular Medicine, University of Leeds, Chapel Allerton Hospital, Chapeltown Road, Leeds LS7 4SA, UK.

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http://ard.bmj.com/cgi/doi/10.1136/ard.2010.146068
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http://dx.doi.org/10.1136/ard.2010.146068DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3184239PMC
November 2011

Efficacy and safety of CH-1504, a metabolically stable antifolate, in patients with active rheumatoid arthritis: results of a phase II multicenter randomized study.

J Rheumatol 2011 Sep 1;38(9):1875-83. Epub 2011 Jul 1.

Rebecca MacDonald Centre for Arthritis and Autoimmune Disease, Mount Sinai Hospital, Joseph and Wolf Lebovic Building, 60 Murray Street, Room 2-006, PO Box 4, Toronto, Ontario M5G 1X5, Canada.

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http://dx.doi.org/10.3899/jrheum.101038DOI Listing
September 2011

Does anti-tumor necrosis factor-α therapy affect risk of serious infection and cancer in patients with rheumatoid arthritis?: a review of longterm data.

J Rheumatol 2011 Aug 15;38(8):1552-62. Epub 2011 May 15.

Rebecca MacDonald Centre for Arthritis and Autoimmune Diseases, Mount Sinai Hospital, Toronto, Ontario, Canada.

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http://dx.doi.org/10.3899/jrheum.100995DOI Listing
August 2011

Challenges in diagnosing latent tuberculosis infection in patients treated with tumor necrosis factor antagonists.

J Rheumatol 2011 Jul 1;38(7):1234-43. Epub 2011 Apr 1.

Rebecca MacDonald Centre for Arthritis and Autoimmune Diseases, Mount Sinai Hospital, Toronto, ON, Canada.

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http://dx.doi.org/10.3899/jrheum.100623DOI Listing
July 2011

Clinical consequences of delayed addition of adalimumab to methotrexate therapy over 5 years in patients with rheumatoid arthritis.

J Rheumatol 2011 May 1;38(5):855-62. Epub 2011 Feb 1.

Division of Advanced Therapeutics, Rebecca MacDonald Centre for Arthritis and Autoimmune Disease, Mount Sinai Hospital, 60 Murray Street, Toronto, Ontario, Canada.

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http://dx.doi.org/10.3899/jrheum.100752DOI Listing
May 2011

Factors associated with radiographic progression in patients with rheumatoid arthritis who were treated with methotrexate.

J Rheumatol 2011 Feb 15;38(2):242-6. Epub 2010 Nov 15.

Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA.

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http://dx.doi.org/10.3899/jrheum.091446DOI Listing
February 2011

Response times follow lognormal or gamma distribution in arthritis patients.

J Clin Epidemiol 2010 Dec;63(12):1363-9

Child Health Evaluative Sciences program, The Hospital for Sick Children Research Institute, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.jclinepi.2009.11.019DOI Listing
December 2010

Are physician-derived joint counts obsolete?

J Rheumatol 2010 May;37(5):883-4

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http://dx.doi.org/10.3899/jrheum.100242DOI Listing
May 2010

From Bedside to Bench: the Role of Anti-Tumor Necrosis Factor Agents in the Management of Immune-Mediated Inflammatory Diseases.

J Rheumatol Suppl 2010 May;85

Université de Montréal, CHUM, Hôpital Notre Dame, Montreal, Quebec, Canada.

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http://dx.doi.org/10.3899/jrheum.091460DOI Listing
May 2010

Tumor necrosis factor and anti-tumor necrosis factor therapies.

J Rheumatol Suppl 2010 May;85:27-39

Rebecca MacDonald Centre for Arthritis and Autoimmune Disease and Division of Advanced Therapeutics in Arthritis, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.3899/jrheum.091463DOI Listing
May 2010

Fibrocyte activation in rheumatoid arthritis.

Rheumatology (Oxford) 2010 Apr 25;49(4):640-51. Epub 2009 Oct 25.

Toronto General Research Institute, University Health Network, 67 College Street, 4-424, Toronto, Ontario M5G 2M1, Canada.

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http://dx.doi.org/10.1093/rheumatology/kep265DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2909797PMC
April 2010

Can tumor necrosis factor inhibitors be safely used in pregnancy?

J Rheumatol 2010 Jan 15;37(1):9-17. Epub 2009 Dec 15.

Department of Clinical Immunology and Allergy, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.3899/jrheum.090563DOI Listing
January 2010