Edward Bilsky

Edward Bilsky

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Edward Bilsky

Edward Bilsky

Publications by authors named "Edward Bilsky"

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Long-term morphine delivery via slow release morphine pellets or osmotic pumps: Plasma concentration, analgesia, and naloxone-precipitated withdrawal.

Life Sci 2017 Sep 16;185:1-7. Epub 2017 Jul 16.

University of New England, College of Osteopathic Medicine, Biddeford, ME 04005, United States; University of New England, Center for Excellence in the Neurosciences, Biddeford, ME 04005, United States.

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https://linkinghub.elsevier.com/retrieve/pii/S00243205173034
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http://dx.doi.org/10.1016/j.lfs.2017.07.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5577921PMC
September 2017

Peripherally Acting µ-Opioid Receptor Antagonists for the Treatment of Opioid-Related Side Effects: Mechanism of Action and Clinical Implications.

J Pharm Pract 2017 Sep 25:897190017732263. Epub 2017 Sep 25.

2 Pacific Northwest University of Health Sciences, Yakima, WA, USA.

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http://dx.doi.org/10.1177/0897190017732263DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6291905PMC
September 2017

Exercise reverses pain-related weight asymmetry and differentially modulates trabecular bone microarchitecture in a rat model of osteoarthritis.

Life Sci 2017 Jul 11;180:51-59. Epub 2017 May 11.

Department of Psychology, University of New England, Biddeford, ME 04005, United States; Center for Excellence in the Neurosciences, University of New England, United States. Electronic address:

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http://dx.doi.org/10.1016/j.lfs.2017.05.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5549619PMC
July 2017

FAAH inhibitor OL-135 disrupts contextual, but not auditory, fear conditioning in rats.

Behav Brain Res 2016 07 13;308:1-5. Epub 2016 Apr 13.

Department of Biomedical Sciences, United States; Center for Excellence in the Neurosciences, University of New England, United States.

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http://dx.doi.org/10.1016/j.bbr.2016.04.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4877211PMC
July 2016

17-Cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-(4'-pyridylcarboxamido)morphinan (NAP) Modulating the Mu Opioid Receptor in a Biased Fashion.

ACS Chem Neurosci 2016 Mar 8;7(3):297-304. Epub 2016 Jan 8.

Department of Pharmacology and Toxicology, Virginia Commonwealth University , 410 North 12th Street, Richmond, Virginia 23298, United States.

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http://dx.doi.org/10.1021/acschemneuro.5b00245DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5111356PMC
March 2016

Structural Requirements for CNS Active Opioid Glycopeptides.

J Med Chem 2015 Aug 23;58(15):5728-41. Epub 2015 Jul 23.

†Carl S. Marvel Laboratories, Department of Chemistry and Biochemistry, BIO5, The University of Arizona, Tucson, Arizona 85721, United States.

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http://dx.doi.org/10.1021/acs.jmedchem.5b00014DOI Listing
August 2015

The mixed-action delta/mu opioid agonist MMP-2200 does not produce conditioned place preference but does maintain drug self-administration in rats, and induces in vitro markers of tolerance and dependence.

Pharmacol Biochem Behav 2015 05 28;132:49-55. Epub 2015 Feb 28.

Department of Biomedical Sciences, University of New England College of Osteopathic Medicine, Biddeford, ME 04005, United States; Center for Excellence in the Neurosciences, University of New England, United States.

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http://dx.doi.org/10.1016/j.pbb.2015.02.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4552603PMC
May 2015

K-12 Neuroscience Education Outreach Program: Interactive Activities for Educating Students about Neuroscience.

J Undergrad Neurosci Educ 2014 15;13(1):A8-A20. Epub 2014 Oct 15.

Psychology Department, University of New England, Biddeford, ME 04005. ; Center for Excellence in the Neurosciences, University of New England, Biddeford, ME 04005.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4281050PMC
January 2015

Behavioral and cellular pharmacology characterization of 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6α-(isoquinoline-3'-carboxamido)morphinan (NAQ) as a mu opioid receptor selective ligand.

Eur J Pharmacol 2014 Aug 8;736:124-30. Epub 2014 May 8.

Department of Biomedical Sciences, College of Osteopathic Medicine, University of New England, 11 Hills Beach Road, Biddeford, ME 04005, United States.

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http://dx.doi.org/10.1016/j.ejphar.2014.04.041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4073486PMC
August 2014

Can amphipathic helices influence the CNS antinociceptive activity of glycopeptides related to β-endorphin?

J Med Chem 2014 Mar 7;57(6):2237-46. Epub 2014 Mar 7.

Department of Chemistry & Biochemistry and BIO5, The University of Arizona , Tucson, Arizona 85721, United States.

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http://dx.doi.org/10.1021/jm400879wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3983389PMC
March 2014

6β-N-heterocyclic substituted naltrexamine derivative NAP as a potential lead to develop peripheral mu opioid receptor selective antagonists.

Bioorg Med Chem Lett 2012 Jul 26;22(14):4731-4. Epub 2012 May 26.

Department of Medicinal Chemistry, Virginia Commonwealth University, 800 East Leigh Street, PO Box 980540, Richmond, VA 23298, United States.

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http://dx.doi.org/10.1016/j.bmcl.2012.05.075DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3395321PMC
July 2012

Opioid glycopeptide analgesics derived from endogenous enkephalins and endorphins.

Future Med Chem 2012 Feb;4(2):205-26

Department of Chemistry & Biochemistry, BIO5, The University of Arizona, Tucson, AZ 85721, USA.

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http://dx.doi.org/10.4155/fmc.11.195DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3306179PMC
February 2012

Phosphorylation of enkephalins: NMR and CD studies in aqueous and membrane-mimicking environments.

Chem Biol Drug Des 2011 Nov 26;78(5):749-56. Epub 2011 Sep 26.

Carl S. Marvel Laboratories, Department of Chemistry and Biochemistry, BIO5, The University of Arizona, Tucson, AZ 85721, USA.

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http://dx.doi.org/10.1111/j.1747-0285.2011.01203.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3193572PMC
November 2011

Selective ablation of mu-opioid receptor expressing neurons in the rostral ventromedial medulla attenuates stress-induced mechanical hypersensitivity.

Life Sci 2011 Aug 6;89(9-10):313-9. Epub 2011 Jul 6.

Department of Biomedical Sciences, College of Osteopathic Medicine, University of New England, 11 Hills Beach Rd, Biddeford, ME 04005, USA.

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http://dx.doi.org/10.1016/j.lfs.2011.06.024DOI Listing
August 2011

In vivo characterization of MMP-2200, a mixed δ/μ opioid agonist, in mice.

J Pharmacol Exp Ther 2011 Mar 30;336(3):767-78. Epub 2010 Nov 30.

Department of Pharmacology, University of New England, College of Osteopathic Medicine, Biddeford, ME 04005, USA.

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http://dx.doi.org/10.1124/jpet.110.172866DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3061528PMC
March 2011

In vitro and in vivo assessment of mu opioid receptor constitutive activity.

Methods Enzymol 2010 ;484:413-43

Department of Biomedical Sciences, College of Osteopathic Medicine, University of New England, Biddeford, Maine, USA.

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http://dx.doi.org/10.1016/B978-0-12-381298-8.00021-6DOI Listing
February 2011

Rationale and methods for assessment of pain-depressed behavior in preclinical assays of pain and analgesia.

Methods Mol Biol 2010 ;617:79-91

Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA, USA.

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http://dx.doi.org/10.1007/978-1-60327-323-7_7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5788447PMC
June 2010

In vivo characterization of the opioid antagonist nalmefene in mice.

Life Sci 2010 Apr 14;86(15-16):624-30. Epub 2010 Feb 14.

Department of Nurse Anesthesia, Westbrook College of Health Professions, University of New England, Portland, ME 04103, United States.

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http://dx.doi.org/10.1016/j.lfs.2010.02.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2848904PMC
April 2010

6beta-naltrexol preferentially antagonizes opioid effects on gastrointestinal transit compared to antinociception in mice.

Life Sci 2009 Sep 5;85(11-12):413-20. Epub 2009 Jul 5.

AIKO Biotechnology, Portland, ME 04101, United States.

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http://dx.doi.org/10.1016/j.lfs.2009.06.016DOI Listing
September 2009

Glycosyl-enkephalins: synthesis and binding at the mu, delta & kappa opioid receptors. Antinociception in mice.

Adv Exp Med Biol 2009 ;611:495-6

Department of Chemistry, The University of Arizona, Tucson, AZ 85721, USA.

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http://dx.doi.org/10.1007/978-0-387-73657-0_214DOI Listing
June 2009

Design, synthesis, and characterization of 6beta-naltrexol analogs, and their selectivity for in vitro opioid receptor subtypes.

Bioorg Med Chem Lett 2009 May 26;19(10):2811-4. Epub 2009 Mar 26.

University of New England, Chemistry & Physics Department, Biddeford, ME, United States.

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http://dx.doi.org/10.1016/j.bmcl.2009.03.095DOI Listing
May 2009

Behavioral pharmacology of the mu/delta opioid glycopeptide MMP2200 in rhesus monkeys.

J Pharmacol Exp Ther 2008 Sep 29;326(3):939-48. Epub 2008 May 29.

Alcohol and Drug Abuse Research Center, McLean Hospital, Harvard Medical School, Belmont, Massachusetts, USA.

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http://dx.doi.org/10.1124/jpet.108.138180DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2587285PMC
September 2008

Opioid ligands with mixed properties from substituted enantiomeric N-phenethyl-5-phenylmorphans. Synthesis of a micro-agonist delta-antagonist and delta-inverse agonists.

Org Biomol Chem 2007 Apr 1;5(8):1177-1190. Epub 2007 Mar 1.

Drug Design and Synthesis Section, Chemical Biology Research Branch, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892-0815, USA.

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http://dx.doi.org/10.1039/b618875cDOI Listing
April 2007

Glycosylation improves the central effects of DAMGO.

Chem Biol Drug Des 2007 Jan;69(1):41-7

Department of Pharmacology, University of New England, 11 Hill Beach Rd., Biddeford, Maine 04005, USA.

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http://dx.doi.org/10.1111/j.1747-0285.2007.00462.xDOI Listing
January 2007

Targeting pain-suppressed behaviors in preclinical assays of pain and analgesia: effects of morphine on acetic acid-suppressed feeding in C57BL/6J mice.

J Pain 2006 Jun;7(6):408-16

Alcohol and Drug Abuse Research Center, McLean Hospital-Harvard Medical School, Belmont, Massachusetts 02478, USA.

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http://dx.doi.org/10.1016/j.jpain.2006.01.447DOI Listing
June 2006

Spinal L-type calcium channel blockade abolishes opioid-induced sensory hypersensitivity and antinociceptive tolerance.

Anesth Analg 2005 Dec;101(6):1730-5

Department of Pharmacology, College of Medicine, University of Arizona, AHSC, 1501 North Campbell Ave., Tucson, AZ 85724, USA.

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http://dx.doi.org/10.1213/01.ANE.0000184253.49849.B0DOI Listing
December 2005

Chronic morphine up-regulates G alpha12 and cytoskeletal proteins in Chinese hamster ovary cells expressing the cloned mu opioid receptor.

J Pharmacol Exp Ther 2005 Oct 29;315(1):248-55. Epub 2005 Jun 29.

Clinical Psychopharmacology Section, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, MD 21224-2735, USA.

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http://dx.doi.org/10.1124/jpet.105.089367DOI Listing
October 2005

Glycopeptides related to beta-endorphin adopt helical amphipathic conformations in the presence of lipid bilayers.

J Am Chem Soc 2005 Apr;127(15):5435-48

The Carl S. Marvel Laboratories, Department of Chemistry, The University of Arizona, 1306 East University Blvd., Tucson, Arizona 85721, USA.

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http://dx.doi.org/10.1021/ja0432158DOI Listing
April 2005

Basal opioid receptor activity, neutral antagonists, and therapeutic opportunities.

Life Sci 2005 Feb 8;76(13):1427-37. Epub 2004 Dec 8.

Department of Pharmacology, College of Medicine and Public Health, The Ohio State University, Columbus, OH 43210, USA.

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http://dx.doi.org/10.1016/j.lfs.2004.10.024DOI Listing
February 2005

Basal signaling activity of mu opioid receptor in mouse brain: role in narcotic dependence.

J Pharmacol Exp Ther 2004 Feb 4;308(2):512-20. Epub 2003 Nov 4.

Department of Biopharmaceutical Sciences and Pharmaceutical Chemistry, Wheeler Center for Neurobiology of Addiction, University of California San Francisco,

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http://dx.doi.org/10.1124/jpet.103.054049DOI Listing
February 2004