Edward B Lee

Edward B Lee

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Edward B Lee

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Targeted DNA methylation of neurodegenerative disease genes via homology directed repair.

Nucleic Acids Res 2019 Nov 4. Epub 2019 Nov 4.

Translational Neuropathology Research Laboratory, Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.1093/nar/gkz979DOI Listing
November 2019

Genetic predictors of survival in behavioral variant frontotemporal degeneration.

Neurology 2019 Oct 19;93(18):e1707-e1714. Epub 2019 Sep 19.

From the Department of Biostatistics, Epidemiology, and Informatics (C.C., S.X.X.), Department of Neurology (C.T.M., D.J.I., M.G., L.M.M.), Penn Frontotemporal Degeneration Center (C.T.M., D.J.I., M.G., L.M.M.), Translational Neuropathology Research Laboratory (E.B.L.), Department of Pathology and Laboratory Medicine (V.M.V.D., E.B.L., J.Q.T., V.M.-Y.L.), and Center for Neurodegenerative Disease Research (V.M.V.D., E.S., E.B.L., J.Q.T., V.M.-Y.L.), Perelman School of Medicine, University of Pennsylvania, Philadelphia.

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http://dx.doi.org/10.1212/WNL.0000000000008387DOI Listing
October 2019

Diffusion Tensor MRI to Distinguish Progressive Supranuclear Palsy from α-Synucleinopathies.

Radiology 2019 Oct 15:190406. Epub 2019 Oct 15.

From the Clinical Memory Research Unit, Department of Clinical Sciences, Malmö, Lund University, Sölvegatan 19, 22100 Lund, Sweden (N.S., S.H., D.v.W., O.H.); Penn Frontotemporal Degeneration Center, Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pa (N.S., D.J.I., M.G., C.T.M.); Memory Clinic, Skåne University Hospital, Malmö, Sweden (S.H., O.H.); Center for Neurodegenerative Disease Research, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pa (D.J.I., E.B.L., J.Q.T.); Department of Diagnostic Radiology, Lund University, Lund, Sweden (T.R., D.v.W., M.N.); Wellcome Centre for Human Neuroimaging, UCL Queen Square Institute of Neurology, University College London, London, England (J.A.C.); Parkinson's Disease and Movement Disorders Center, Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pa (A.F.D., M.A.S.); Alzheimer's Disease Core Center, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pa (E.B.L., J.Q.T.); and Queensland Brain Institute, University of Queensland and Mater Misericordiae, Brisbane, Queensland, Australia (P.J.N.).

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http://dx.doi.org/10.1148/radiol.2019190406DOI Listing
October 2019

Chronic traumatic encephalopathy is a common co-morbidity, but less frequent primary dementia in former soccer and rugby players.

Acta Neuropathol 2019 Sep 1;138(3):389-399. Epub 2019 Jun 1.

Department of Neuropathology, Queen Elizabeth University Hospital, 1345 Govan Rd, Glasgow, G51 4TF, UK.

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http://dx.doi.org/10.1007/s00401-019-02030-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6689293PMC
September 2019

Empiric Methods to Account for Pre-analytical Variability in Digital Histopathology in Frontotemporal Lobar Degeneration.

Front Neurosci 2019 3;13:682. Epub 2019 Jul 3.

Penn Digital Neuropathology Laboratory, Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States.

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http://dx.doi.org/10.3389/fnins.2019.00682DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6616086PMC
July 2019

Genome-wide analyses as part of the international FTLD-TDP whole-genome sequencing consortium reveals novel disease risk factors and increases support for immune dysfunction in FTLD.

Authors:
Cyril Pottier Yingxue Ren Ralph B Perkerson Matt Baker Gregory D Jenkins Marka van Blitterswijk Mariely DeJesus-Hernandez Jeroen G J van Rooij Melissa E Murray Elizabeth Christopher Shannon K McDonnell Zachary Fogarty Anthony Batzler Shulan Tian Cristina T Vicente Billie Matchett Anna M Karydas Ging-Yuek Robin Hsiung Harro Seelaar Merel O Mol Elizabeth C Finger Caroline Graff Linn Öijerstedt Manuela Neumann Peter Heutink Matthis Synofzik Carlo Wilke Johannes Prudlo Patrizia Rizzu Javier Simon-Sanchez Dieter Edbauer Sigrun Roeber Janine Diehl-Schmid Bret M Evers Andrew King M Marsel Mesulam Sandra Weintraub Changiz Geula Kevin F Bieniek Leonard Petrucelli Geoffrey L Ahern Eric M Reiman Bryan K Woodruff Richard J Caselli Edward D Huey Martin R Farlow Jordan Grafman Simon Mead Lea T Grinberg Salvatore Spina Murray Grossman David J Irwin Edward B Lee EunRan Suh Julie Snowden David Mann Nilufer Ertekin-Taner Ryan J Uitti Zbigniew K Wszolek Keith A Josephs Joseph E Parisi David S Knopman Ronald C Petersen John R Hodges Olivier Piguet Ethan G Geier Jennifer S Yokoyama Robert A Rissman Ekaterina Rogaeva Julia Keith Lorne Zinman Maria Carmela Tartaglia Nigel J Cairns Carlos Cruchaga Bernardino Ghetti Julia Kofler Oscar L Lopez Thomas G Beach Thomas Arzberger Jochen Herms Lawrence S Honig Jean Paul Vonsattel Glenda M Halliday John B Kwok Charles L White Marla Gearing Jonathan Glass Sara Rollinson Stuart Pickering-Brown Jonathan D Rohrer John Q Trojanowski Vivianna Van Deerlin Eileen H Bigio Claire Troakes Safa Al-Sarraj Yan Asmann Bruce L Miller Neill R Graff-Radford Bradley F Boeve William W Seeley Ian R A Mackenzie John C van Swieten Dennis W Dickson Joanna M Biernacka Rosa Rademakers

Acta Neuropathol 2019 Jun 9;137(6):879-899. Epub 2019 Feb 9.

Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL, 32224, USA.

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http://link.springer.com/10.1007/s00401-019-01962-9
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http://dx.doi.org/10.1007/s00401-019-01962-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6533145PMC
June 2019

Divergent patterns of TDP-43 and tau pathologies in primary progressive aphasia.

Ann Neurol 2019 May 28;85(5):630-643. Epub 2019 Mar 28.

Penn Frontotemporal Degeneration Center, Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.

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http://dx.doi.org/10.1002/ana.25465DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6538935PMC
May 2019

Histologic, immunohistochemical, and molecular features of pituicytomas and atypical pituicytomas.

Acta Neuropathol Commun 2019 May 2;7(1):69. Epub 2019 May 2.

Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.

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https://actaneurocomms.biomedcentral.com/articles/10.1186/s4
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http://dx.doi.org/10.1186/s40478-019-0722-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6498683PMC
May 2019

Loss of Nuclear TDP-43 Is Associated with Decondensation of LINE Retrotransposons.

Cell Rep 2019 Apr;27(5):1409-1421.e6

Translational Neuropathology Research Laboratory, Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.04.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6508629PMC
April 2019

Elevated YKL-40 and low sAPPβ:YKL-40 ratio in antemortem cerebrospinal fluid of patients with pathologically confirmed FTLD.

J Neurol Neurosurg Psychiatry 2019 Feb 8;90(2):180-186. Epub 2018 Oct 8.

Sant Pau Memory Unit, Department of Neurology, Institut d'Investigacions Biomèdiques Sant Pau - Hospital de Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain

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http://jnnp.bmj.com/lookup/doi/10.1136/jnnp-2018-318993
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http://dx.doi.org/10.1136/jnnp-2018-318993DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351153PMC
February 2019

Converging Patterns of α-Synuclein Pathology in Multiple System Atrophy.

J Neuropathol Exp Neurol 2018 11;77(11):1005-1016

Center for Neurodegenerative Disease Research (CNDR), University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1093/jnen/nly080DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6181179PMC
November 2018

Patient-derived frontotemporal lobar degeneration brain extracts induce formation and spreading of TDP-43 pathology in vivo.

Nat Commun 2018 10 11;9(1):4220. Epub 2018 Oct 11.

Center for Neurodegenerative Disease Research (CNDR), Institute on Aging, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.

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http://www.nature.com/articles/s41467-018-06548-9
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http://dx.doi.org/10.1038/s41467-018-06548-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6181940PMC
October 2018

Cerebrospinal fluid α-synuclein contributes to the differential diagnosis of Alzheimer's disease.

Alzheimers Dement 2018 08 28;14(8):1052-1062. Epub 2018 Mar 28.

Department of Pathology, University of Washington School of Medicine, Seattle, WA, USA; Department of Pathology, Peking University Health Science Centre and Third Hospital, Beijing, China. Electronic address:

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http://dx.doi.org/10.1016/j.jalz.2018.02.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6097943PMC
August 2018

Alzheimer's genetic risk is reduced in primary age-related tauopathy: a potential model of resistance?

Ann Clin Transl Neurol 2018 Aug 19;5(8):927-934. Epub 2018 Jun 19.

Department of Neurology Perelman School of Medicine University of Pennsylvania Philadelphia Pennsylvania.

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http://dx.doi.org/10.1002/acn3.581DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6093846PMC
August 2018

Potential genetic modifiers of disease risk and age at onset in patients with frontotemporal lobar degeneration and GRN mutations: a genome-wide association study.

Authors:
Cyril Pottier Xiaolai Zhou Ralph B Perkerson Matt Baker Gregory D Jenkins Daniel J Serie Roberta Ghidoni Luisa Benussi Giuliano Binetti Adolfo López de Munain Miren Zulaica Fermin Moreno Isabelle Le Ber Florence Pasquier Didier Hannequin Raquel Sánchez-Valle Anna Antonell Albert Lladó Tammee M Parsons NiCole A Finch Elizabeth C Finger Carol F Lippa Edward D Huey Manuela Neumann Peter Heutink Matthis Synofzik Carlo Wilke Robert A Rissman Jaroslaw Slawek Emilia Sitek Peter Johannsen Jørgen E Nielsen Yingxue Ren Marka van Blitterswijk Mariely DeJesus-Hernandez Elizabeth Christopher Melissa E Murray Kevin F Bieniek Bret M Evers Camilla Ferrari Sara Rollinson Anna Richardson Elio Scarpini Giorgio G Fumagalli Alessandro Padovani John Hardy Parastoo Momeni Raffaele Ferrari Francesca Frangipane Raffaele Maletta Maria Anfossi Maura Gallo Leonard Petrucelli EunRan Suh Oscar L Lopez Tsz H Wong Jeroen G J van Rooij Harro Seelaar Simon Mead Richard J Caselli Eric M Reiman Marwan Noel Sabbagh Mads Kjolby Anders Nykjaer Anna M Karydas Adam L Boxer Lea T Grinberg Jordan Grafman Salvatore Spina Adrian Oblak M-Marsel Mesulam Sandra Weintraub Changiz Geula John R Hodges Olivier Piguet William S Brooks David J Irwin John Q Trojanowski Edward B Lee Keith A Josephs Joseph E Parisi Nilüfer Ertekin-Taner David S Knopman Benedetta Nacmias Irene Piaceri Silvia Bagnoli Sandro Sorbi Marla Gearing Jonathan Glass Thomas G Beach Sandra E Black Mario Masellis Ekaterina Rogaeva Jean-Paul Vonsattel Lawrence S Honig Julia Kofler Amalia C Bruni Julie Snowden David Mann Stuart Pickering-Brown Janine Diehl-Schmid Juliane Winkelmann Daniela Galimberti Caroline Graff Linn Öijerstedt Claire Troakes Safa Al-Sarraj Carlos Cruchaga Nigel J Cairns Jonathan D Rohrer Glenda M Halliday John B Kwok John C van Swieten Charles L White Bernardino Ghetti Jill R Murell Ian R A Mackenzie Ging-Yuek R Hsiung Barbara Borroni Giacomina Rossi Fabrizio Tagliavini Zbigniew K Wszolek Ronald C Petersen Eileen H Bigio Murray Grossman Vivianna M Van Deerlin William W Seeley Bruce L Miller Neill R Graff-Radford Bradley F Boeve Dennis W Dickson Joanna M Biernacka Rosa Rademakers

Lancet Neurol 2018 06 30;17(6):548-558. Epub 2018 Apr 30.

Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA. Electronic address:

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http://dx.doi.org/10.1016/S1474-4422(18)30126-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6237181PMC
June 2018

Sequential stages and distribution patterns of aging-related tau astrogliopathy (ARTAG) in the human brain.

Acta Neuropathol Commun 2018 06 11;6(1):50. Epub 2018 Jun 11.

Center for Neurodegenerative Disease Research (CNDR), Institute on Aging and Department of Pathology & Laboratory Medicine, Perelman School of Medicine (PSOM) at the University of Pennsylvania, HUP Maloney 3rd Floor, 36th and Spruce Street, Philadelphia, PA, 19104 - 4283, USA.

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http://dx.doi.org/10.1186/s40478-018-0552-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5996526PMC
June 2018

Integrated neurodegenerative disease autopsy diagnosis.

Authors:
Edward B Lee

Acta Neuropathol 2018 04 3;135(4):643-646. Epub 2018 Mar 3.

Translational Neuropathology Research Laboratory, University of Pennsylvania, 613A Stellar Chance Laboratories, 422 Curie Blvd, Philadelphia, PA, 19104, USA.

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http://dx.doi.org/10.1007/s00401-018-1827-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6186396PMC
April 2018

Tauopathy with hippocampal 4-repeat tau immunoreactive spherical inclusions: a report of three cases.

Brain Pathol 2018 03 19;28(2):274-283. Epub 2017 Jan 19.

Center for Neurodegenerative Disease Research, Institute on Aging and Department of Pathology & Laboratory Medicine, Philadelphia, PA.

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http://dx.doi.org/10.1111/bpa.12482DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5484758PMC
March 2018

Neocortical origin and progression of gray matter atrophy in nonamnestic Alzheimer's disease.

Neurobiol Aging 2018 03 21;63:75-87. Epub 2017 Nov 21.

Penn Frontotemporal Degeneration Center, University of Pennsylvania, Philadelphia, PA, USA; Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.1016/j.neurobiolaging.2017.11.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5801003PMC
March 2018

CSF tau and β-amyloid predict cerebral synucleinopathy in autopsied Lewy body disorders.

Neurology 2018 03 21;90(12):e1038-e1046. Epub 2018 Feb 21.

From Penn Frontotemporal Degeneration Center (D.J.I., N.N., C.T.M., M.G.), Alzheimer's Disease Core Center (D.A.W., J.Q.T.), Department of Neurology (D.J.I., D.C., R.S.A., C.T.M., D.A.W., D.W., A.C.-P., M.S., A.S., H.I.H., M.G.), Penn Morris K. Udall Parkinson's Disease Research Center of Excellence (D.J.I., R.S.A., C.T.M., D.W., A.C.-P., J.E.D., M.G., J.Q.T.), Center for Neurodegenerative Disease Research (L.M.S., J.Q.T.), Translational Neuropathology Research Laboratory (E.B.L.), Department of Pathology and Laboratory Medicine (E.B.L., L.M.S., J.Q.T.), and Department of Biostatistics and Epidemiology Perelman School of Medicine (S.X.X.), University of Pennsylvania; and Parkinson's Disease Research, Education and Clinical Center (D.W., J.E.D.), Michael J. Crescenz VA Medical Center, Philadelphia, PA.

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http://www.neurology.org/lookup/doi/10.1212/WNL.000000000000
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http://dx.doi.org/10.1212/WNL.0000000000005166DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5874449PMC
March 2018

Cognitive decline associated with pathological burden in primary age-related tauopathy.

Alzheimers Dement 2017 Sep 16;13(9):1048-1053. Epub 2017 Mar 16.

Department of Neurology, University of Pennsylvania, Philadelphia, PA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jalz.2017.01.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5585025PMC
September 2017

Neuron loss and degeneration in the progression of TDP-43 in frontotemporal lobar degeneration.

Acta Neuropathol Commun 2017 09 6;5(1):68. Epub 2017 Sep 6.

Center for Neurodegenerative Disease Research and Institute on Aging, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA.

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http://dx.doi.org/10.1186/s40478-017-0471-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5586052PMC
September 2017

Ante mortem cerebrospinal fluid tau levels correlate with postmortem tau pathology in frontotemporal lobar degeneration.

Ann Neurol 2017 Aug 19;82(2):247-258. Epub 2017 Aug 19.

Frontotemporal Degeneration Center, Department of Neurology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA.

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http://dx.doi.org/10.1002/ana.24996DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5776747PMC
August 2017

Multisite Assessment of Aging-Related Tau Astrogliopathy (ARTAG).

J Neuropathol Exp Neurol 2017 Jul;76(7):605-619

Institute of Neurology, Medical University of Vienna, Vienna, Austria; Center for Neurodegenerative Disease Research, Institute on Aging and Department of Pathology and Laboratory Medicine of the Perelman School of Medicine at the University of Pennsylvania; and Department of Biostatistics and Epidemiology; and Department of Neurosurgery, Center for Brain Injury and Repair, University of Pennsylvania, Philadelphia, Pennsylvania; Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden; Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, UK; Department of Neuropathology, Institute of Pathology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary; Department of Neuroscience, Mayo Clinic, Jacksonville, Florida; Northwestern University Feinberg School of Medicine, Northwestern ADC Neuropathology Core, Chicago, Illinois; Clinical Neuropathology, King's College Hospital and London Neurodegenerative Brain Bank, London, UK; Institute of Neuropathology, University Hospital Zurich, Zurich, Switzerland; University of California San Francisco, Institute for Neurodegenerative Diseases, San Francisco, California; Neuropathology Department, Hôpital de La Salpetrière, AP-HP, UPMC-Sorbonne-University, Paris, France; Institute of Neuropathology, Bellvitge University Hospital, University of Barcelona, CIBERNED, Hospitalet de Llobregat, Barcelona, Spain; Discipline of Pathology, Sydney Medical School, The University of Sydney, Sydney, Australia; Neurological Tissue Bank of the Biobank-Hospital Clinic-IDIBAPS, Institut d'Investigacions Biomediques Pi i, Barcelona, Spain; Department of Medicine, Imperial College London, London, UK; IRCCS Foundation "Carlo Besta" Neurological Institute, Milan, Italy; Memory and Aging Center, Department of Neurology, University of California, San Francisco, California; Department of Pathology, University of Sao Paulo Medical School, LIM, São Paulo, Brazil; Brain & Mind Centre, Sydney Medical School, The University of Sydney, and UNSW Medicine & NeuRA, Sydney, Australia; Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas; Fishberg Department of Neuroscience, Friedman Brain Institute, and Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, New York; Department of Neuropathology, John Radcliffe Hospital, Oxford, UK; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK; Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania; Department of Mental Health and Psychiatry, University Hospitals and University of Geneva School of Medicine, Geneva, Switzerland; Institute of Clinical Neurosciences, University of Bristol, Learning & Research Level 2, Southmead Hospital, Bristol, UK; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada; Department of Pathology and Molecular Medicine, Thomayer Hospital, Prague, Czech Republic; Department of Pathology, First Medical Faculty, Charles University, Prague, Czech Republic; Department of Anatomical Pathology, Alfred Hospital , Prahran, Victoria, Australia; Division of Pathology, St. Michael's Hospital, Toronto, Ontario, Canada; Department of Pathology and Sanders-Brown Center on Aging, University of Kentucky, Lexington, Kentucky; Physiopathology in Aging Lab/Brazilian Aging Brain Study Group-LIM22, University of Sao Paulo Medical School, Sao Paulo, Brazil; Behavioral and Cognitive Neurology Unit, Department of Neurology, University of São Paulo , São Paulo, Brazil; Netherlands Brainbank, Amsterdam and Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands; Department of Neurology and Neurobiology of Aging, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan; Institute of Neuroanatomy, Centre for Biomedicine and Medical Technology Mannheim, Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany; Department of Neurodegenerative Diseases and Gerontopsychiatry at the University of Bonn Medical Center, Bonn, Germany; Department of Pathology, Brain Research Institute, Niigata University, Niigata, Japan; Department of Neurology, Saitama Medical University International Medical Center, Saitama, Japan; Department of Neuroscience, Katholieke Universiteit-Leuven; and Department of Pathology, Universitaire Ziekenhuizen-Leuven, Leuven, Belgium; Laboratory of Neuropathology, Department of Pathology and Neuropathology, Kepler University Hospital, Medical School, Johannes Kepler University, Linz, Austria; Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield, UK; and Department of Pathology and Laboratory Medicine, Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, University of Ottawa, Ontario, Canada.

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http://dx.doi.org/10.1093/jnen/nlx041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6251511PMC
July 2017

Editorial overview: Molecular & genetic basis of disease.

Curr Opin Genet Dev 2017 06 2;44:iv-vi. Epub 2017 May 2.

Department of Neurology, Duke University School of Medicine, United States.

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http://dx.doi.org/10.1016/j.gde.2017.04.003DOI Listing
June 2017

Clinical marker for Alzheimer disease pathology in logopenic primary progressive aphasia.

Neurology 2017 Jun 17;88(24):2276-2284. Epub 2017 May 17.

From the Department of Neurology (L.A.A.G.), University Medical Center Groningen, University of Groningen, the Netherlands; Penn Frontotemporal Degeneration Center, Department of Neurology (L.A.A.G., D.J.I., C.T.M., S.A., K.R., M.G.), Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine (D.J.I., V.M.V.D., J.Q.T.), Alzheimer's Disease Center (D.A.W.), Department of Neurology, and Translational Pathology Laboratory, Perelman School of Medicine (E.B.L.), University of Pennsylvania, Philadelphia.

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http://dx.doi.org/10.1212/WNL.0000000000004034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5567322PMC
June 2017

RNA metabolism in neurodegenerative disease.

Dis Model Mech 2017 05;10(5):509-518

Translational Neuropathology Research Laboratories, Perelman School of Med. Univ. of Pennsylvania, 613A Stellar Chance Laboratories, Philadelphia, PA 19104, USA

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http://dmm.biologists.org/lookup/doi/10.1242/dmm.028613
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http://dx.doi.org/10.1242/dmm.028613DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5451173PMC
May 2017

Decision-Making Deficits Associated with Amyloidosis in Lewy Body Disorders.

Front Hum Neurosci 2016 11;10:693. Epub 2017 Jan 11.

Penn Frontotemporal Degeneration Center, University of Pennsylvania Perelman School of Medicine Philadelphia, PA, USA.

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http://dx.doi.org/10.3389/fnhum.2016.00693DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5225123PMC
January 2017

Multimodal evaluation demonstrates in vivo F-AV-1451 uptake in autopsy-confirmed corticobasal degeneration.

Acta Neuropathol 2016 12 4;132(6):935-937. Epub 2016 Nov 4.

Department of Neurology, Perelman School of Medicine, University of Pennsylvania, 3400 Spruce Street, 3 West Gates, Philadelphia, PA, 19104, USA.

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http://dx.doi.org/10.1007/s00401-016-1640-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5154298PMC
December 2016

Cognitive reserve in frontotemporal degeneration: Neuroanatomic and neuropsychological evidence.

Neurology 2016 Oct 28;87(17):1813-1819. Epub 2016 Sep 28.

From the Department of Neurology, Penn Frontotemporal Degeneration Center (K.P., L.M., C.O., K.T., K.F., D.I., M.G., C.T.M.), and Department of Pathology & Laboratory Medicine, Center for Neurodegenerative Disease Research (V.V.D., E.B.L., J.Q.T., V.M.-Y.L., D.I.), University of Pennsylvania, Philadelphia.

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http://dx.doi.org/10.1212/WNL.0000000000003250DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5089523PMC
October 2016

Multimodal imaging evidence of pathology-mediated disease distribution in corticobasal syndrome.

Neurology 2016 Sep 19;87(12):1227-34. Epub 2016 Aug 19.

From the Department of Neurology (C.T.M., C.B., R.G.G., J.W., K.F., K.R., D.A.W., D.J.I., M.G.) and Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine (J.B.T., L.S., D.J.I., E.B.L., J.Q.T.), Perelman School of Medicine, University of Pennsylvania, Philadelphia.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5035978PMC
http://dx.doi.org/10.1212/WNL.0000000000003119DOI Listing
September 2016

Multisite assessment of NIA-AA guidelines for the neuropathologic evaluation of Alzheimer's disease.

Alzheimers Dement 2016 Feb 29;12(2):164-169. Epub 2015 Aug 29.

Department of Neurology, Massachusetts General Hospital, Charleston, MA, USA; Massachusetts Alzheimer's Disease Research Center, Massachusetts General Hospital, Charleston, MA, USA.

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http://dx.doi.org/10.1016/j.jalz.2015.07.492DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4562409PMC
February 2016

Deep clinical and neuropathological phenotyping of Pick disease.

Ann Neurol 2016 Feb 25;79(2):272-87. Epub 2015 Dec 25.

Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4755803PMC
February 2016

Semi-Automated Digital Image Analysis of Pick's Disease and TDP-43 Proteinopathy.

J Histochem Cytochem 2016 01 4;64(1):54-66. Epub 2015 Nov 4.

Center for Neurodegenerative Disease Research,Department of Pathology & Laboratory Medicine(DJI, MDB, FC, SEA, EBL, VMVD, VML, JQT)

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http://dx.doi.org/10.1369/0022155415614303DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4810792PMC
January 2016

Aging-related tau astrogliopathy (ARTAG): harmonized evaluation strategy.

Acta Neuropathol 2016 Jan 10;131(1):87-102. Epub 2015 Dec 10.

Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL, 32224, USA.

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http://dx.doi.org/10.1007/s00401-015-1509-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4879001PMC
January 2016

C9orf72 BAC Transgenic Mice Display Typical Pathologic Features of ALS/FTD.

Neuron 2015 Dec;88(5):892-901

Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, CA 90048, USA; Department of Neurology, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, CA 90048, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2015.10.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4672384PMC
December 2015

Semi-automated quantification of C9orf72 expansion size reveals inverse correlation between hexanucleotide repeat number and disease duration in frontotemporal degeneration.

Acta Neuropathol 2015 Sep 29;130(3):363-72. Epub 2015 May 29.

Department of Pathology and Laboratory Medicine, Center for Neurodegenerative Disease Research, Perelman School of Medicine at the University of Pennsylvania, 3600 Spruce Street, Philadelphia, PA, 19104-4283, USA,

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http://dx.doi.org/10.1007/s00401-015-1445-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4545720PMC
September 2015

Common neuropathological features underlie distinct clinical presentations in three siblings with hereditary diffuse leukoencephalopathy with spheroids caused by CSF1R p.Arg782His.

Acta Neuropathol Commun 2015 Jul 4;3:42. Epub 2015 Jul 4.

Department of Pathology and Laboratory Medicine, Center for Neurodegenerative Disease Research, Perelman School of Medicine at the University of Pennsylvania, 3600 Spruce Street, 19104, Philadelphia, PA, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4491242PMC
July 2015

Erratum to: Sequential distribution of pTDP-43 pathology in behavioral variant frontotemporal dementia (bvFTD).

Acta Neuropathol 2015 Jun;129(6):929

Center for Neurodegenerative Disease Research (CNDR), Perelman School of Medicine at the University of Pennsylvania, 3rd Floor Maloney Building, 3600 Spruce Street, Philadelphia, PA, 19104, USA,

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June 2015

Frontotemporal lobar degeneration: defining phenotypic diversity through personalized medicine.

Acta Neuropathol 2015 Apr 31;129(4):469-91. Epub 2014 Dec 31.

Department of Pathology and Laboratory Medicine, Center for Neurodegenerative Disease Research, Institute on Ageing, University of Pennsylvania School of Medicine, HUP Maloney 3rd Floor, 36th and Spruce Streets, Philadelphia, PA, 19104-4283, USA.

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http://dx.doi.org/10.1007/s00401-014-1380-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4369168PMC
April 2015

C9orf72 promoter hypermethylation is neuroprotective: Neuroimaging and neuropathologic evidence.

Neurology 2015 Apr 20;84(16):1622-30. Epub 2015 Mar 20.

From the Penn Frontotemporal Degeneration Center (C.T.M., D.J.I., M.G.), Penn Medicine Neuroscience Center at Pennsylvania Hospital (L.M., L.E.), Department of Neurology (C.T.M., D.J.I., M.G., L.M., L.E.), Translational Neuropathology Research Laboratory (J.R., E.B.L.), Center for Neurodegenerative Disease Research, Department of Pathology & Laboratory Medicine (E.M.W., D.J.I., V.V.D.), Institute for Translation Medicine & Therapeutics (C.T.M., D.J.I.), the University of Pennsylvania Perelman School of Medicine, Philadelphia.

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http://dx.doi.org/10.1212/WNL.0000000000001495DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4409587PMC
April 2015

Hypermethylation of repeat expanded C9orf72 is a clinical and molecular disease modifier.

Acta Neuropathol 2015 Jan 12;129(1):39-52. Epub 2014 Nov 12.

Translational Neuropathology Research Laboratory, Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, 605B Stellar Chance Laboratories, 422 Curie Blvd, Philadelphia, PA, 19104, USA.

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http://dx.doi.org/10.1007/s00401-014-1365-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4282973PMC
January 2015

C9orf72 hypermethylation protects against repeat expansion-associated pathology in ALS/FTD.

Acta Neuropathol 2014 Oct 8;128(4):525-41. Epub 2014 May 8.

Translational Neuropathology Research Laboratory, Perelman School of Medicine at the University of Pennsylvania, 605B Stellar Chance Laboratories, 422 Curie Blvd, Philadelphia, PA, 19104, USA.

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http://dx.doi.org/10.1007/s00401-014-1286-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4161616PMC
October 2014

A comparison of Aβ amyloid pathology staging systems and correlation with clinical diagnosis.

Acta Neuropathol 2014 Oct 12;128(4):543-50. Epub 2014 Jun 12.

Department of Pathology and Laboratory Medicine, Center for Neurodegenerative Disease Research, Institute on Aging, University of Pennsylvania School of Medicine, Philadelphia, PA, 19104, USA.

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http://dx.doi.org/10.1007/s00401-014-1308-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4399383PMC
October 2014

TDP-43 pathology and neuronal loss in amyotrophic lateral sclerosis spinal cord.

Acta Neuropathol 2014 Sep 12;128(3):423-37. Epub 2014 Jun 12.

Center for Neurodegenerative Disease Research (CNDR), University of Pennsylvania School of Medicine, 3rd Floor Maloney Building, 3600 Spruce Street, Philadelphia, PA, 19104, USA,

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http://link.springer.com/10.1007/s00401-014-1299-6
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4384652PMC
September 2014

Perforant path synaptic loss correlates with cognitive impairment and Alzheimer's disease in the oldest-old.

Brain 2014 Sep 9;137(Pt 9):2578-87. Epub 2014 Jul 9.

1 Centre for Neurodegenerative Disease Research, Institute on Aging and Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA

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http://dx.doi.org/10.1093/brain/awu190DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4132652PMC
September 2014

Poly-A binding protein-1 localization to a subset of TDP-43 inclusions in amyotrophic lateral sclerosis occurs more frequently in patients harboring an expansion in C9orf72.

J Neuropathol Exp Neurol 2014 Sep;73(9):837-45

From the Department of Biology, University of Pennsylvania (LM, NMB); Translational Neuropathology Research Laboratory, Stellar Chance Laboratories (EBL); and Department of Pathology and Laboratory Medicine, Perelman School of Medicine (VML, JQT, VMVD, EBL), Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1097/NEN.0000000000000102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4149258PMC
September 2014

The neuropathology of obesity: insights from human disease.

Acta Neuropathol 2014 Jan 6;127(1):3-28. Epub 2013 Oct 6.

Translational Neuropathology Research Laboratory, Division of Neuropathology, Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, 605B Stellar Chance Laboratories, 422 Curie Blvd, Philadelphia, PA, 19104, USA,

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http://dx.doi.org/10.1007/s00401-013-1190-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3880612PMC
January 2014

Comparative survey of the topographical distribution of signature molecular lesions in major neurodegenerative diseases.

J Comp Neurol 2013 Dec;521(18):4339-55

Penn Memory Center, Departments of Psychiatry and Neurology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, 19104.

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http://dx.doi.org/10.1002/cne.23430DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3872132PMC
December 2013

Development and validation of pedigree classification criteria for frontotemporal lobar degeneration.

JAMA Neurol 2013 Nov;70(11):1411-7

Department of Pathology and Laboratory Medicine, Center for Neurodegenerative Disease Research, Perelman School of Medicine at the University of Pennsylvania, Philadelphia.

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http://dx.doi.org/10.1001/jamaneurol.2013.3956DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3906581PMC
November 2013

Stages of pTDP-43 pathology in amyotrophic lateral sclerosis.

Ann Neurol 2013 Jul 19;74(1):20-38. Epub 2013 Jun 19.

Center for Neurodegenerative Disease Research (CNDR), University of Pennsylvania School of Medicine, 3rd Floor Maloney Building, 3600 Spruce Street, Philadelphia, PA 19104, USA.

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http://doi.wiley.com/10.1002/ana.23937
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3785076PMC
July 2013

Topography of FUS pathology distinguishes late-onset BIBD from aFTLD-U.

Acta Neuropathol Commun 2013 May;1(9):1-11

Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA ; Translational Neuropathology Research Laboratory, 605B Stellar Chance Laboratories, 422 Curie Blvd, Philadelphia, PA 19104, USA ; Department of Pathology and Laboratory Medicine, Philadelphia, PA, USA.

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http://dx.doi.org/10.1186/2051-5960-1-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3767453PMC
May 2013

Pattern of ubiquilin pathology in ALS and FTLD indicates presence of C9ORF72 hexanucleotide expansion.

Acta Neuropathol 2012 Jun 18;123(6):825-39. Epub 2012 Mar 18.

Center for Neurodegenerative Disease Research (CNDR), University of Pennsylvania School of Medicine, 3rd Floor Maloney Building, 3600 Spruce Street, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1007/s00401-012-0970-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3521561PMC
June 2012

Determination of grade and subtype of meningiomas by using histogram analysis of diffusion-tensor imaging metrics.

Radiology 2012 Feb 14;262(2):584-92. Epub 2011 Nov 14.

Department of Radiology, Hospital of the University of Pennsylvania, 3400 Spruce St, 219 Dulles Bldg, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1148/radiol.11110576DOI Listing
February 2012

Alteration of hypothalamic cellular dynamics in obesity.

J Clin Invest 2012 Jan 27;122(1):22-5. Epub 2011 Dec 27.

Department of Pathology and Laboratory Medicine, Perelman School of Medicine at University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1172/JCI61562DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3248311PMC
January 2012

Obesity, leptin, and Alzheimer's disease.

Authors:
Edward B Lee

Ann N Y Acad Sci 2011 Dec;1243:15-29

Translational Neuropathology Research Laboratory, Division of Neuropathology, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1111/j.1749-6632.2011.06274.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3564488PMC
December 2011

Gains or losses: molecular mechanisms of TDP43-mediated neurodegeneration.

Nat Rev Neurosci 2011 Nov 30;13(1):38-50. Epub 2011 Nov 30.

Translational Neuropathology Research Laboratory, Division of Neuropathology, Department of Pathology and Laboratory Medicine, University of Pennsylvania, 605B Stellar Chance Laboratories, 422 Curie Boulevard, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1038/nrn3121DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3285250PMC
November 2011

Metabolic dysfunction associated with adiponectin deficiency enhances kainic acid-induced seizure severity.

J Neurosci 2011 Oct;31(40):14361-6

Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1523/JNEUROSCI.3171-11.2011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3195357PMC
October 2011

α-Syn suppression reverses synaptic and memory defects in a mouse model of dementia with Lewy bodies.

J Neurosci 2011 Jul;31(27):10076-87

Department of Pathology and Laboratory Medicine, Institute on Aging and Center for Neurodegenerative Disease Research, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1523/JNEUROSCI.0618-11.2011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3144489PMC
July 2011

Intraneuronal APP, not free Aβ peptides in 3xTg-AD mice: implications for tau versus Aβ-mediated Alzheimer neurodegeneration.

J Neurosci 2011 May;31(21):7691-9

Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1523/JNEUROSCI.6637-10.2011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3118598PMC
May 2011

Dysregulation of the ALS-associated gene TDP-43 leads to neuronal death and degeneration in mice.

J Clin Invest 2011 Feb 4;121(2):726-38. Epub 2011 Jan 4.

Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, and Institute on Aging, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1172/JCI44867DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3026736PMC
February 2011

Photo essay. MRI and positron emission tomography findings in Heidenhain variant Creutzfeldt-Jakob disease.

J Neuroophthalmol 2010 Sep;30(3):260-2

Departments of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1097/WNO.0b013e3181e2aef7DOI Listing
September 2010

Idiopathic eosinophilic meningoencephalomyelitis following Well syndrome.

Neurology 2009 Dec;73(23):2037-9

Department of Neurology, University of Pennsylvania Health System, Philadelphia, PA 19104, USA.

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http://www.neurology.org/cgi/doi/10.1212/WNL.0b013e3181c55ee
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http://dx.doi.org/10.1212/WNL.0b013e3181c55ee7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2790232PMC
December 2009

Hemangiomas of the brachial plexus: a case series.

Neurosurgery 2009 Oct;65(4 Suppl):A181-8

Department of Neurosurgery, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1227/01.NEU.0000335643.41581.1DDOI Listing
October 2009

Thyroid transcription factor 1 expression in sellar tumors: a histogenetic marker?

J Neuropathol Exp Neurol 2009 May;68(5):482-8

Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania 19106, USA.

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http://dx.doi.org/10.1097/NEN.0b013e3181a13fcaDOI Listing
May 2009

Primary diffuse leptomeningeal gliomatosis mimicking a chronic inflammatory meningitis.

J Neurol Sci 2009 Mar 8;278(1-2):127-31. Epub 2009 Jan 8.

Department of Neurology, State University of New York Upstate Medical University, Syracuse, NY 13202, USA.

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http://dx.doi.org/10.1016/j.jns.2008.11.026DOI Listing
March 2009

TDP-43 immunoreactivity in anoxic, ischemic and neoplastic lesions of the central nervous system.

Acta Neuropathol 2008 Mar 18;115(3):305-11. Epub 2007 Dec 18.

Department of Pathology and Laboratory Medicine, Center for Neurodegenerative Disease Research, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

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http://link.springer.com/content/pdf/10.1007/s00401-007-0331
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http://link.springer.com/10.1007/s00401-007-0331-5
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March 2008

Supranuclear vertical gaze abnormalities in sporadic Creutzfeldt-Jakob disease.

J Neurol Sci 2007 Feb 17;253(1-2):69-72. Epub 2007 Jan 17.

Department of Neurology, Hospital of the University of Pennsylvania, Philadelphia 19104, United States.

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http://dx.doi.org/10.1016/j.jns.2006.11.010DOI Listing
February 2007

Targeting amyloid-beta peptide (Abeta) oligomers by passive immunization with a conformation-selective monoclonal antibody improves learning and memory in Abeta precursor protein (APP) transgenic mice.

J Biol Chem 2006 Feb 16;281(7):4292-9. Epub 2005 Dec 16.

Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, 19104, USA.

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http://www.jbc.org/cgi/doi/10.1074/jbc.M511018200
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February 2006

Meningoencephalitis associated with passive immunization of a transgenic murine model of Alzheimer's amyloidosis.

FEBS Lett 2005 May 7;579(12):2564-8. Epub 2005 Apr 7.

Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, HUP, Philadelphia, 19104-4283, USA.

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http://dx.doi.org/10.1016/j.febslet.2005.03.070DOI Listing
May 2005

Microtubule-binding drugs offset tau sequestration by stabilizing microtubules and reversing fast axonal transport deficits in a tauopathy model.

Proc Natl Acad Sci U S A 2005 Jan 22;102(1):227-31. Epub 2004 Dec 22.

Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, 3600 Spruce Street, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1073/pnas.0406361102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC544048PMC
January 2005

BACE overexpression alters the subcellular processing of APP and inhibits Abeta deposition in vivo.

J Cell Biol 2005 Jan 10;168(2):291-302. Epub 2005 Jan 10.

The Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine.

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http://dx.doi.org/10.1083/jcb.200407070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2171598PMC
January 2005

Genetically modified NT2N human neuronal cells mediate long-term gene expression as CNS grafts in vivo and improve functional cognitive outcome following experimental traumatic brain injury.

J Neuropathol Exp Neurol 2003 Apr;62(4):368-80

Department of Pathobiology, Center for Comparative Medical Genetics, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, USA.

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http://dx.doi.org/10.1093/jnen/62.4.368DOI Listing
April 2003

Secretion and intracellular generation of truncated Abeta in beta-site amyloid-beta precursor protein-cleaving enzyme expressing human neurons.

J Biol Chem 2003 Feb 11;278(7):4458-66. Epub 2002 Dec 11.

Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA.

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February 2003

Distribution of a lysosomal enzyme in the adult brain by axonal transport and by cells of the rostral migratory stream.

J Neurosci 2002 Aug;22(15):6437-46

Department of Pathobiology and Center for Comparative Medical Genetics, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/20026665DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6758166PMC
August 2002