Edward A Miao

Edward A Miao

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Edward A Miao

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Programmed Cell Death in the Evolutionary Race against Bacterial Virulence Factors.

Cold Spring Harb Perspect Biol 2019 Sep 9. Epub 2019 Sep 9.

Department of Microbiology and Immunology, Center for Gastrointestinal Biology and Disease, and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.

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http://dx.doi.org/10.1101/cshperspect.a036459DOI Listing
September 2019

NLRP1 - One NLR to guard them all.

EMBO J 2019 Jul 12;38(13):e102494. Epub 2019 Jun 12.

Department of Microbiology and Immunology, Center for Gastrointestinal Biology and Disease, and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

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http://dx.doi.org/10.15252/embj.2019102494DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6600648PMC
July 2019

NLRP1 - One NLR to guard them all.

EMBO J 2019 Jun 12. Epub 2019 Jun 12.

Department of Microbiology and Immunology, Center for Gastrointestinal Biology and Disease, and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

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http://dx.doi.org/10.15252/embj.2019102494DOI Listing
June 2019

A licence to kill during inflammation.

Nature 2019 Jun;570(7761):316-317

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http://dx.doi.org/10.1038/d41586-019-01764-9DOI Listing
June 2019

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

Authors:
Lorenzo Galluzzi Ilio Vitale Stuart A Aaronson John M Abrams Dieter Adam Patrizia Agostinis Emad S Alnemri Lucia Altucci Ivano Amelio David W Andrews Margherita Annicchiarico-Petruzzelli Alexey V Antonov Eli Arama Eric H Baehrecke Nickolai A Barlev Nicolas G Bazan Francesca Bernassola Mathieu J M Bertrand Katiuscia Bianchi Mikhail V Blagosklonny Klas Blomgren Christoph Borner Patricia Boya Catherine Brenner Michelangelo Campanella Eleonora Candi Didac Carmona-Gutierrez Francesco Cecconi Francis K-M Chan Navdeep S Chandel Emily H Cheng Jerry E Chipuk John A Cidlowski Aaron Ciechanover Gerald M Cohen Marcus Conrad Juan R Cubillos-Ruiz Peter E Czabotar Vincenzo D'Angiolella Ted M Dawson Valina L Dawson Vincenzo De Laurenzi Ruggero De Maria Klaus-Michael Debatin Ralph J DeBerardinis Mohanish Deshmukh Nicola Di Daniele Francesco Di Virgilio Vishva M Dixit Scott J Dixon Colin S Duckett Brian D Dynlacht Wafik S El-Deiry John W Elrod Gian Maria Fimia Simone Fulda Ana J García-Sáez Abhishek D Garg Carmen Garrido Evripidis Gavathiotis Pierre Golstein Eyal Gottlieb Douglas R Green Lloyd A Greene Hinrich Gronemeyer Atan Gross Gyorgy Hajnoczky J Marie Hardwick Isaac S Harris Michael O Hengartner Claudio Hetz Hidenori Ichijo Marja Jäättelä Bertrand Joseph Philipp J Jost Philippe P Juin William J Kaiser Michael Karin Thomas Kaufmann Oliver Kepp Adi Kimchi Richard N Kitsis Daniel J Klionsky Richard A Knight Sharad Kumar Sam W Lee John J Lemasters Beth Levine Andreas Linkermann Stuart A Lipton Richard A Lockshin Carlos López-Otín Scott W Lowe Tom Luedde Enrico Lugli Marion MacFarlane Frank Madeo Michal Malewicz Walter Malorni Gwenola Manic Jean-Christophe Marine Seamus J Martin Jean-Claude Martinou Jan Paul Medema Patrick Mehlen Pascal Meier Sonia Melino Edward A Miao Jeffery D Molkentin Ute M Moll Cristina Muñoz-Pinedo Shigekazu Nagata Gabriel Nuñez Andrew Oberst Moshe Oren Michael Overholtzer Michele Pagano Theocharis Panaretakis Manolis Pasparakis Josef M Penninger David M Pereira Shazib Pervaiz Marcus E Peter Mauro Piacentini Paolo Pinton Jochen H M Prehn Hamsa Puthalakath Gabriel A Rabinovich Markus Rehm Rosario Rizzuto Cecilia M P Rodrigues David C Rubinsztein Thomas Rudel Kevin M Ryan Emre Sayan Luca Scorrano Feng Shao Yufang Shi John Silke Hans-Uwe Simon Antonella Sistigu Brent R Stockwell Andreas Strasser Gyorgy Szabadkai Stephen W G Tait Daolin Tang Nektarios Tavernarakis Andrew Thorburn Yoshihide Tsujimoto Boris Turk Tom Vanden Berghe Peter Vandenabeele Matthew G Vander Heiden Andreas Villunger Herbert W Virgin Karen H Vousden Domagoj Vucic Erwin F Wagner Henning Walczak David Wallach Ying Wang James A Wells Will Wood Junying Yuan Zahra Zakeri Boris Zhivotovsky Laurence Zitvogel Gerry Melino Guido Kroemer

Cell Death Differ 2018 03 23;25(3):486-541. Epub 2018 Jan 23.

Paris Descartes/Paris V University, Paris, France.

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http://dx.doi.org/10.1038/s41418-017-0012-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5864239PMC
March 2018

Caspase-11-mediated endothelial pyroptosis underlies endotoxemia-induced lung injury.

J Clin Invest 2017 Nov 9;127(11):4124-4135. Epub 2017 Oct 9.

Department of Pharmacology, The University of Illinois College of Medicine, Chicago, Illinois, USA.

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http://dx.doi.org/10.1172/JCI94495DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5663346PMC
November 2017

Lipopolysaccharide Potentiates Insulin-Driven Hypoglycemic Shock.

J Immunol 2017 11 16;199(10):3634-3643. Epub 2017 Oct 16.

Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599;

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http://dx.doi.org/10.4049/jimmunol.1700820DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5685187PMC
November 2017

Gasdermins: Effectors of Pyroptosis.

Trends Cell Biol 2017 09 12;27(9):673-684. Epub 2017 Jun 12.

Department of Microbiology and Immunology, Lineberger Comprehensive Cancer Center, and Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09628924173008
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http://dx.doi.org/10.1016/j.tcb.2017.05.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5565696PMC
September 2017

Dietary Salt Exacerbates Experimental Colitis.

J Immunol 2017 08 21;199(3):1051-1059. Epub 2017 Jun 21.

Center for Gastrointestinal Biology and Disease, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599;

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http://www.jimmunol.org/lookup/doi/10.4049/jimmunol.1700356
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http://dx.doi.org/10.4049/jimmunol.1700356DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5576735PMC
August 2017

Programmed cell death as a defence against infection.

Nat Rev Immunol 2017 Mar 31;17(3):151-164. Epub 2017 Jan 31.

Department of Microbiology and Immunology, Lineberger Comprehensive Cancer Center, and Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.

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http://dx.doi.org/10.1038/nri.2016.147DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5328506PMC
March 2017

IL-1β, IL-18, and eicosanoids promote neutrophil recruitment to pore-induced intracellular traps following pyroptosis.

Eur J Immunol 2016 12 19;46(12):2761-2766. Epub 2016 Oct 19.

Department of Microbiology and Immunology, Center for Gastrointestinal Biology and Disease, and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

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http://dx.doi.org/10.1002/eji.201646647DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5138142PMC
December 2016

Loss of Bladder Epithelium Induced by Cytolytic Mast Cell Granules.

Immunity 2016 12 6;45(6):1258-1269. Epub 2016 Dec 6.

Department of Pathology, Duke University, Durham, NC 27710, USA; Department of Molecular Genetics and Microbiology, Duke University, Durham, NC 27710, USA; Department of Immunology, Duke University, Durham, NC 27710, USA; Program in Emerging Infectious Diseases, Duke-National University of Singapore, Singapore 169857, Singapore.

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http://dx.doi.org/10.1016/j.immuni.2016.11.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5177478PMC
December 2016

Pyroptosis triggers pore-induced intracellular traps (PITs) that capture bacteria and lead to their clearance by efferocytosis.

J Exp Med 2016 09 29;213(10):2113-28. Epub 2016 Aug 29.

Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599

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http://dx.doi.org/10.1084/jem.20151613DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5030797PMC
September 2016

Down with doublespeak: NAIP/NLRC4 inflammasomes get specific.

J Exp Med 2016 05;213(5):646

Department of Microbiology and Immunology, Lineberger Comprehensive Cancer Center, and Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill

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http://dx.doi.org/10.1084/jem.2135insight1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854739PMC
May 2016

Reassessing the Evolutionary Importance of Inflammasomes.

J Immunol 2016 Feb;196(3):956-62

Department of Microbiology and Immunology, Center for Gastrointestinal Biology and Disease, and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599

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http://dx.doi.org/10.4049/jimmunol.1502060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4724637PMC
February 2016

Guanylate binding proteins enable rapid activation of canonical and noncanonical inflammasomes in Chlamydia-infected macrophages.

Infect Immun 2015 Dec 28;83(12):4740-9. Epub 2015 Sep 28.

Departments of Molecular Genetics and Microbiology and Immunology, Duke University Medical Center, Durham, North Carolina, USA

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http://dx.doi.org/10.1128/IAI.00856-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4645370PMC
December 2015

Inflammasomes Coordinate Pyroptosis and Natural Killer Cell Cytotoxicity to Clear Infection by a Ubiquitous Environmental Bacterium.

Immunity 2015 Nov 10;43(5):987-97. Epub 2015 Nov 10.

Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2015.10.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4654968PMC
November 2015

Canonical Inflammasomes Drive IFN-γ to Prime Caspase-11 in Defense against a Cytosol-Invasive Bacterium.

Cell Host Microbe 2015 Sep 27;18(3):320-32. Epub 2015 Aug 27.

Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA; Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S19313128150030
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http://dx.doi.org/10.1016/j.chom.2015.07.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4567510PMC
September 2015

Pyroptotic cell death defends against intracellular pathogens.

Immunol Rev 2015 May;265(1):130-42

Department of Microbiology and Immunology, Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

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http://dx.doi.org/10.1111/imr.12287DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4400865PMC
May 2015

Yersinia pestis activates both IL-1β and IL-1 receptor antagonist to modulate lung inflammation during pneumonic plague.

PLoS Pathog 2015 Mar 17;11(3):e1004688. Epub 2015 Mar 17.

Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1004688DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4363893PMC
March 2015

The RIP1-RIP3 complex initiates mitochondrial fission to fuel NLRP3.

Nat Immunol 2014 Dec;15(12):1100-2

Department of Microbiology and Immunology, the Lineberger Comprehensive Cancer Center and the Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

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http://dx.doi.org/10.1038/ni.3030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5115691PMC
December 2014

NAIP inflammasomes give the NOD to bacterial ligands.

Trends Immunol 2014 Nov 18;35(11):503-4. Epub 2014 Oct 18.

Department of Microbiology and Immunology, Center for Gastrointestinal Biology and Disease, and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA. Electronic address:

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http://dx.doi.org/10.1016/j.it.2014.10.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4254492PMC
November 2014

NLRC4 and TLR5 each contribute to host defense in respiratory melioidosis.

PLoS Negl Trop Dis 2014 Sep 18;8(9):e3178. Epub 2014 Sep 18.

Division of Pulmonary & Critical Care Medicine, Department of Medicine, University of Washington School of Medicine, Seattle, Washington, United States of America.

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https://dx.plos.org/10.1371/journal.pntd.0003178
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http://dx.doi.org/10.1371/journal.pntd.0003178DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4169243PMC
September 2014

Guanylate binding proteins promote caspase-11-dependent pyroptosis in response to cytoplasmic LPS.

Proc Natl Acad Sci U S A 2014 Apr 8;111(16):6046-51. Epub 2014 Apr 8.

Departments of Molecular Genetics and Microbiology and Immunology, Duke University Medical Center, Durham, NC 27710.

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http://dx.doi.org/10.1073/pnas.1321700111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4000848PMC
April 2014

Detection of pyroptosis by measuring released lactate dehydrogenase activity.

Methods Mol Biol 2013 ;1040:85-90

Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

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http://dx.doi.org/10.1007/978-1-62703-523-1_7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3756820PMC
February 2014

miniMAVS, You Complete Me!

Cell 2014 Feb;156(4):629-30

Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2014.01.045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5097455PMC
February 2014

Detection of cytosolic bacteria by inflammatory caspases.

Curr Opin Microbiol 2014 Feb 22;17:61-6. Epub 2013 Dec 22.

Department of Microbiology and Immunology and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Electronic address:

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http://dx.doi.org/10.1016/j.mib.2013.11.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3942666PMC
February 2014

Salmonella typhimurium impedes innate immunity with a mast-cell-suppressing protein tyrosine phosphatase, SptP.

Immunity 2013 Dec;39(6):1108-20

Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA; Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA; Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA; Program in Emerging Infectious Diseases, Duke - National University of Singapore Graduate Medical School, Singapore 169857, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2013.11.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4326046PMC
December 2013

Cutting edge: Mouse NAIP1 detects the type III secretion system needle protein.

J Immunol 2013 Oct 16;191(8):3986-9. Epub 2013 Sep 16.

Department of Microbiology and Immunology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599;

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http://dx.doi.org/10.4049/jimmunol.1301549DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3819181PMC
October 2013

Cytoplasmic LPS activates caspase-11: implications in TLR4-independent endotoxic shock.

Science 2013 Sep;341(6151):1250-3

Department of Microbiology and Immunology and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.1126/science.1240988DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3931427PMC
September 2013

Mechanisms of NOD-like receptor-associated inflammasome activation.

Immunity 2013 Sep;39(3):432-41

The Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.1016/j.immuni.2013.08.037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3835203PMC
September 2013

Inflammasome-mediated pyroptotic and apoptotic cell death, and defense against infection.

Curr Opin Microbiol 2013 Jun 23;16(3):319-26. Epub 2013 May 23.

Department of Microbiology and Immunology and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.1016/j.mib.2013.04.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3742712PMC
June 2013

Caspase-11 protects against bacteria that escape the vacuole.

Science 2013 Feb 24;339(6122):975-8. Epub 2013 Jan 24.

Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.1126/science.1230751DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3697099PMC
February 2013

Just say NO to NLRP3.

Nat Immunol 2013 Jan;14(1):12-4

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http://dx.doi.org/10.1038/ni.2493DOI Listing
January 2013

YopM puts caspase-1 on ice.

Cell Host Microbe 2012 Dec;12(6):737-8

Department of Microbiology and Immunology and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.1016/j.chom.2012.11.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3590850PMC
December 2012

Salmonella and Caspase-1: A complex Interplay of Detection and Evasion.

Front Microbiol 2011 25;2:85. Epub 2011 Apr 25.

Department of Microbiology and Immunology, University of North Carolina Chapel Hill, NC, USA.

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http://dx.doi.org/10.3389/fmicb.2011.00085DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3153046PMC
November 2011

Caspase-1-induced pyroptotic cell death.

Immunol Rev 2011 Sep;243(1):206-14

Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.1111/j.1600-065X.2011.01044.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3609431PMC
September 2011

Generation of a Listeria vaccine strain by enhanced caspase-1 activation.

Eur J Immunol 2011 Jul 8;41(7):1934-40. Epub 2011 Jun 8.

Institute for Systems Biology, Seattle, WA 98109, USA.

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http://dx.doi.org/10.1002/eji.201041214DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3375905PMC
July 2011

The NLRP3 inflammasome detects encephalomyocarditis virus and vesicular stomatitis virus infection.

J Virol 2011 May 2;85(9):4167-72. Epub 2011 Feb 2.

Institute for Systems Biology, 1441 34th Avenue N., Seattle, WA 98104, USA.

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http://dx.doi.org/10.1128/JVI.01687-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3126243PMC
May 2011

Differential requirements for NAIP5 in activation of the NLRC4 inflammasome.

Infect Immun 2011 Apr 31;79(4):1606-14. Epub 2011 Jan 31.

School of Public Health, Division of Immunology & Pathogenesis, , University ofCalifornia, Berkeley, California 94720, USA.

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http://dx.doi.org/10.1128/IAI.01187-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3067536PMC
April 2011

Activation of the NLRP3 inflammasome by intracellular poly I:C.

FEBS Lett 2010 Nov 23;584(22):4627-32. Epub 2010 Oct 23.

Institute for Systems Biology, Seattle, WA 98103, USA.

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http://doi.wiley.com/10.1016/j.febslet.2010.10.036
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http://dx.doi.org/10.1016/j.febslet.2010.10.036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3005299PMC
November 2010

Innate immune detection of bacterial virulence factors via the NLRC4 inflammasome.

J Clin Immunol 2010 Jul 27;30(4):502-6. Epub 2010 Mar 27.

Institute for Systems Biology, 1441 N 34th St, Seattle, WA 98103, USA.

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http://dx.doi.org/10.1007/s10875-010-9386-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2993241PMC
July 2010

Multiple Nod-like receptors activate caspase 1 during Listeria monocytogenes infection.

J Immunol 2008 Jun;180(11):7558-64

Department of Immunology, University of Washington, Seattle WA 98195, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2991040PMC
http://dx.doi.org/10.4049/jimmunol.180.11.7558DOI Listing
June 2008

Pseudomonas aeruginosa activates caspase 1 through Ipaf.

Proc Natl Acad Sci U S A 2008 Feb 6;105(7):2562-7. Epub 2008 Feb 6.

Institute for Systems Biology, Seattle, WA 98103, USA.

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http://dx.doi.org/10.1073/pnas.0712183105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2268176PMC
February 2008

TLR5 and Ipaf: dual sensors of bacterial flagellin in the innate immune system.

Semin Immunopathol 2007 Sep 10;29(3):275-88. Epub 2007 Aug 10.

Institute for Systems Biology, Seattle, WA 98103, USA.

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http://link.springer.com/10.1007/s00281-007-0078-z
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http://dx.doi.org/10.1007/s00281-007-0078-zDOI Listing
September 2007

Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1beta via Ipaf.

Nat Immunol 2006 Jun 30;7(6):569-75. Epub 2006 Apr 30.

Institute for Systems Biology, Seattle, Washington 98103, USA.

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http://dx.doi.org/10.1038/ni1344DOI Listing
June 2006

Salmonella effectors translocated across the vacuolar membrane interact with the actin cytoskeleton.

Mol Microbiol 2003 Apr;48(2):401-15

Department of Microbiology, University of Washington, HSB K-140, Box 357710, Seattle, WA 98195-7710, USA.

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http://dx.doi.org/10.1046/j.1365-2958.2003.t01-1-03456.xDOI Listing
April 2003

Transcription of the SsrAB regulon is repressed by alkaline pH and is independent of PhoPQ and magnesium concentration.

J Bacteriol 2002 Mar;184(5):1493-7

Department of Microbiology, Health Sciences Building, University of Washington, Seattle, WA 98195, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC134869PMC
http://dx.doi.org/10.1128/jb.184.5.1493-1497.2002DOI Listing
March 2002