Publications by authors named "Edurne San José-Enériz"

38 Publications

Targeting aberrant DNA methylation in mesenchymal stromal cells as a treatment for myeloma bone disease.

Authors:
Antonio Garcia-Gomez Tianlu Li Carlos de la Calle-Fabregat Javier Rodríguez-Ubreva Laura Ciudad Francesc Català-Moll Gerard Godoy-Tena Montserrat Martín-Sánchez Laura San-Segundo Sandra Muntión Xabier Morales Carlos Ortiz-de-Solórzano Julen Oyarzabal Edurne San José-Enériz Manel Esteller Xabier Agirre Felipe Prosper Mercedes Garayoa Esteban Ballestar

Nat Commun 2021 01 18;12(1):421. Epub 2021 Jan 18.

Epigenetics and Immune Disease Group, Josep Carreras Leukaemia Research Institute (IJC), Badalona, 08916, Badalona, Barcelona, Spain.

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January 2021

Chromatin activation as a unifying principle underlying pathogenic mechanisms in multiple myeloma.

Authors:
Raquel Ordoñez Marta Kulis Nuria Russiñol Vicente Chapaprieta Arantxa Carrasco-Leon Beatriz García-Torre Stella Charalampopoulou Guillem Clot Renée Beekman Cem Meydan Martí Duran-Ferrer Núria Verdaguer-Dot Roser Vilarrasa-Blasi Paula Soler-Vila Leire Garate Estíbaliz Miranda Edurne San José-Enériz Juan R Rodriguez-Madoz Teresa Ezponda Rebeca Martínez-Turrilas Amaia Vilas-Zornoza David Lara-Astiaso Daphné Dupéré-Richer Joost H A Martens Halima El-Omri Ruba Y Taha Maria J Calasanz Bruno Paiva Jesus San Miguel Paul Flicek Ivo Gut Ari Melnick Constantine S Mitsiades Jonathan D Licht Elias Campo Hendrik G Stunnenberg Xabier Agirre Felipe Prosper Jose I Martin-Subero

Genome Res 2020 Sep 20;30(9):1217-1227. Epub 2020 Aug 20.

Centro de Investigación Biomédica en Red de Cáncer, CIBERONC, 28029 Madrid, Spain.

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September 2020

Immunogenomic identification and characterization of granulocytic myeloid-derived suppressor cells in multiple myeloma.

Authors:
Cristina Perez Cirino Botta Aintzane Zabaleta Noemi Puig Maria-Teresa Cedena Ibai Goicoechea Daniel Alameda Edurne San José-Eneriz Juana Merino Paula Rodríguez-Otero Catarina Maia Diego Alignani Patricia Maiso Irene Manrique David Lara-Astiaso Amaia Vilas-Zornoza Sarai Sarvide Caterina Riillo Marco Rossi Laura Rosiñol Albert Oriol María-Jesús Blanchard Rafael Rios Anna Sureda Jesus Martin Rafael Martinez Joan Bargay Javier de la Rubia Miguel-Teodoro Hernandez Joaquin Martinez-Lopez Alberto Orfao Xabier Agirre Felipe Prosper Maria-Victoria Mateos Juan-José Lahuerta Joan Blade Jesús F San-Miguel Bruno Paiva

Blood 2020 07;136(2):199-209

Clinica Universidad de Navarra, Centro de Investigacion Medica Aplicada (CIMA), Instituto de Investigacion Sanitaria de Navarra (IDISNA), CIBER-ONC numbers CB16/12/00369, CB16/12/00489, Pamplona, Spain.

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July 2020

HDAC Inhibitors in Acute Myeloid Leukemia.

Authors:
Edurne San José-Enériz Naroa Gimenez-Camino Xabier Agirre Felipe Prosper

Cancers (Basel) 2019 Nov 14;11(11). Epub 2019 Nov 14.

Área de Hemato-Oncología, Centro de Investigación Médica Aplicada, Instituto de Investigación Sanitaria de Navarra (IDISNA), Universidad de Navarra, 31008 Pamplona, Spain.

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November 2019

Inhibition of a G9a/DNMT network triggers immune-mediated bladder cancer regression.

Authors:
Cristina Segovia Edurne San José-Enériz Ester Munera-Maravilla Mónica Martínez-Fernández Leire Garate Estíbaliz Miranda Amaia Vilas-Zornoza Iris Lodewijk Carolina Rubio Carmen Segrelles Luis Vitores Valcárcel Obdulia Rabal Noelia Casares Alejandra Bernardini Cristian Suarez-Cabrera Fernando F López-Calderón Puri Fortes José A Casado Marta Dueñas Felipe Villacampa Juan José Lasarte Félix Guerrero-Ramos Guillermo de Velasco Julen Oyarzabal Daniel Castellano Xabier Agirre Felipe Prósper Jesús M Paramio

Nat Med 2019 07 3;25(7):1073-1081. Epub 2019 Jul 3.

Molecular Oncology Unit CIEMAT, Madrid, Spain.

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July 2019

Epigenomic profiling of myelofibrosis reveals widespread DNA methylation changes in enhancer elements and as a potential tumor suppressor gene that is epigenetically regulated.

Authors:
Nicolás Martínez-Calle Marien Pascual Raquel Ordoñez Edurne San José Enériz Marta Kulis Estíbaliz Miranda Elisabeth Guruceaga Víctor Segura María José Larráyoz Beatriz Bellosillo María José Calasanz Carles Besses José Rifón José I Martín-Subero Xabier Agirre Felipe Prosper

Haematologica 2019 08 17;104(8):1572-1579. Epub 2019 Jan 17.

Área de Hemato-Oncología, Centro de Investigación Médica Aplicada, IDISNA, Universidad de Navarra, Pamplona

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August 2019

Dual Targeting of Histone Methyltransferase G9a and DNA-Methyltransferase 1 for the Treatment of Experimental Hepatocellular Carcinoma.

Authors:
Marina Bárcena-Varela Stefano Caruso Susana Llerena Gloria Álvarez-Sola Iker Uriarte M Ujue Latasa Raquel Urtasun Sandra Rebouissou Laura Alvarez Maddalen Jimenez Eva Santamaría Carlos Rodriguez-Ortigosa Giuseppe Mazza Krista Rombouts Edurne San José-Eneriz Obdulia Rabal Xabier Agirre Maria Iraburu Alvaro Santos-Laso Jesus M Banales Jessica Zucman-Rossi Felipe Prósper Julen Oyarzabal Carmen Berasain Matías A Ávila Maite G Fernández-Barrena

Hepatology 2019 02 4;69(2):587-603. Epub 2019 Jan 4.

Hepatology Program, Cima-University of Navarra, Pamplona, Spain.

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February 2019

Discovery of Reversible DNA Methyltransferase and Lysine Methyltransferase G9a Inhibitors with Antitumoral in Vivo Efficacy.

Authors:
Obdulia Rabal Edurne San José-Enériz Xabier Agirre Juan Antonio Sánchez-Arias Amaia Vilas-Zornoza Ana Ugarte Irene de Miguel Estíbaliz Miranda Leire Garate Mario Fraga Pablo Santamarina Raul Fernandez Perez Raquel Ordoñez Elena Sáez Sergio Roa María José García-Barchino José Angel Martínez-Climent Yingying Liu Wei Wu Musheng Xu Felipe Prosper Julen Oyarzabal

J Med Chem 2018 Aug 19;61(15):6518-6545. Epub 2018 Jul 19.

Departmento de Hematología, Clinica Universidad de Navarra , University of Navarra , Avenida Pio XII 36 , E-31008 Pamplona , Spain.

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August 2018

Detailed Exploration around 4-Aminoquinolines Chemical Space to Navigate the Lysine Methyltransferase G9a and DNA Methyltransferase Biological Spaces.

Authors:
Obdulia Rabal Juan Antonio Sánchez-Arias Edurne San José-Enériz Xabier Agirre Irene de Miguel Leire Garate Estibaliz Miranda Elena Sáez Sergio Roa José Angel Martínez-Climent Yingying Liu Wei Wu Musheng Xu Felipe Prosper Julen Oyarzabal

J Med Chem 2018 Aug 19;61(15):6546-6573. Epub 2018 Jul 19.

Departmento de Hematología, Clinica Universidad de Navarra , University of Navarra , Avenida Pio XII 36 , E-31008 Pamplona , Spain.

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August 2018

Deregulation of in acute lymphoblastic leukemia is implicated in abnormal proliferation of leukemic cells.

Authors:
Andoni Garitano-Trojaola Edurne San José-Enériz Teresa Ezponda Juan Pablo Unfried Arantxa Carrasco-León Nerea Razquin Marina Barriocanal Amaia Vilas-Zornoza Bruno Sangro Victor Segura Felipe Prósper Puri Fortes Xabier Agirre

Oncotarget 2018 Feb 5;9(16):12842-12852. Epub 2018 Feb 5.

Laboratory of Myeloproliferative Syndromes, Oncology Area, Foundation for Applied Medical Research, IDISNA, CIBERONC, University of Navarra, Pamplona, Spain.

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February 2018

COBRA methods and metabolic drug targets in cancer.

Authors:
Iñigo Apaolaza Edurne San José-Eneriz Xabier Agirre Felipe Prósper Francisco J Planes

Mol Cell Oncol 2018 30;5(1):e1389672. Epub 2017 Nov 30.

CEIT and Tecnun, University of Navarra, Manuel de Lardizábal 13, San Sebastián, Spain.

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November 2017

Reversible dual inhibitor against G9a and DNMT1 improves human iPSC derivation enhancing MET and facilitating transcription factor engagement to the genome.

Authors:
Juan Roberto Rodriguez-Madoz Edurne San Jose-Eneriz Obdulia Rabal Natalia Zapata-Linares Estibaliz Miranda Saray Rodriguez Angelo Porciuncula Amaia Vilas-Zornoza Leire Garate Victor Segura Elizabeth Guruceaga Xabier Agirre Julen Oyarzabal Felipe Prosper

PLoS One 2017 27;12(12):e0190275. Epub 2017 Dec 27.

Cell Therapy Program, Center for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain.

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February 2018

In-silico gene essentiality analysis of polyamine biosynthesis reveals APRT as a potential target in cancer.

Authors:
Jon Pey Edurne San José-Eneriz María Carmen Ochoa Iñigo Apaolaza Pedro de Atauri Angel Rubio Xabier Cendoya Estíbaliz Miranda Leire Garate Marta Cascante Arkaitz Carracedo Xabier Agirre Felipe Prosper Francisco J Planes

Sci Rep 2017 10 30;7(1):14358. Epub 2017 Oct 30.

Bioinformatics Group, CEIT and TECNUN, University of Navarra, San Sebastian, 20018, Spain.

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October 2017

An in-silico approach to predict and exploit synthetic lethality in cancer metabolism.

Authors:
Iñigo Apaolaza Edurne San José-Eneriz Luis Tobalina Estíbaliz Miranda Leire Garate Xabier Agirre Felipe Prósper Francisco J Planes

Nat Commun 2017 09 6;8(1):459. Epub 2017 Sep 6.

CEIT and Tecnun, University of Navarra, Manuel de Lardizábal 13, 20018, San Sebastián, Spain.

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September 2017

Dual epigenetic modifiers for cancer therapy.

Authors:
Edurne San José-Enériz Obdulia Rabal Xabier Agirre Julen Oyarzabal Felipe Prosper

Mol Cell Oncol 2017 20;4(4):e1342748. Epub 2017 Jun 20.

Area de Hemato-Oncología, Centro de Investigación Médica Aplicada (CIMA), IDISNA, ciberonc, Universidad de Navarra, Pamplona, Spain.

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June 2017

Discovery of first-in-class reversible dual small molecule inhibitors against G9a and DNMTs in hematological malignancies.

Authors:
Edurne San José-Enériz Xabier Agirre Obdulia Rabal Amaia Vilas-Zornoza Juan A Sanchez-Arias Estibaliz Miranda Ana Ugarte Sergio Roa Bruno Paiva Ander Estella-Hermoso de Mendoza Rosa María Alvarez Noelia Casares Victor Segura José I Martín-Subero François-Xavier Ogi Pierre Soule Clara M Santiveri Ramón Campos-Olivas Giancarlo Castellano Maite Garcia Fernandez de Barrena Juan Roberto Rodriguez-Madoz Maria José García-Barchino Juan Jose Lasarte Matias A Avila Jose Angel Martinez-Climent Julen Oyarzabal Felipe Prosper

Nat Commun 2017 05 26;8:15424. Epub 2017 May 26.

Area de Hemato-Oncología, Centro de Investigación Médica Aplicada, IDISNA, Ciberonc, Universidad de Navarra, Avenida Pío XII, 55 31008 Pamplona, Spain.

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May 2017

Whole-epigenome analysis in multiple myeloma reveals DNA hypermethylation of B cell-specific enhancers.

Authors:
Xabier Agirre Giancarlo Castellano Marien Pascual Simon Heath Marta Kulis Victor Segura Anke Bergmann Anna Esteve Angelika Merkel Emanuele Raineri Lidia Agueda Julie Blanc David Richardson Laura Clarke Avik Datta Nuria Russiñol Ana C Queirós Renée Beekman Juan R Rodríguez-Madoz Edurne San José-Enériz Fang Fang Norma C Gutiérrez José M García-Verdugo Michael I Robson Eric C Schirmer Elisabeth Guruceaga Joost H A Martens Marta Gut Maria J Calasanz Paul Flicek Reiner Siebert Elías Campo Jesús F San Miguel Ari Melnick Hendrik G Stunnenberg Ivo G Gut Felipe Prosper José I Martín-Subero

Genome Res 2015 Apr 2;25(4):478-87. Epub 2015 Feb 2.

Unidad de Hematopatología, Servicio de Anatomía Patológica, Hospital Clínic, Universitat de Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain;

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April 2015

Epigenetic regulation of cell signaling pathways in acute lymphoblastic leukemia.

Authors:
Edurne San Jose-Eneriz Xabier Agirre Paula Rodríguez-Otero Felipe Prosper

Epigenomics 2013 ;5(5):525-38

Oncology Division, Foundation for Applied Medical Research, University of Navarra, Pamplona, Spain.

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April 2016

Down-regulated expression of hsa-miR-181c in Fanconi anemia patients: implications in TNFα regulation and proliferation of hematopoietic progenitor cells.

Authors:
Paula Río Xabier Agirre Leire Garate Rocío Baños Lara Álvarez Edurne San José-Enériz Isabel Badell José A Casado Marina Garín Felipe Prósper Juan A Bueren

Blood 2012 Mar 6;119(13):3042-9. Epub 2012 Feb 6.

Hematopoiesis and Gene Therapy Division, Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas, Madrid, Spain.

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March 2012

Deregulation of FGFR1 and CDK6 oncogenic pathways in acute lymphoblastic leukaemia harbouring epigenetic modifications of the MIR9 family.

Authors:
Paula Rodriguez-Otero José Román-Gómez Amaia Vilas-Zornoza Edurne San José-Eneriz Vanesa Martín-Palanco José Rifón Antonio Torres María José Calasanz Xabier Agirre Felipe Prosper

Br J Haematol 2011 Oct 2;155(1):73-83. Epub 2011 Aug 2.

Division of Cancer, Foundation for Applied Medical Research, Universidad de Navarra, Avenida Pio XII 36, Pamplona, Spain.

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October 2011

Frequent and simultaneous epigenetic inactivation of TP53 pathway genes in acute lymphoblastic leukemia.

Authors:
Amaia Vilas-Zornoza Xabier Agirre Vanesa Martín-Palanco José Ignacio Martín-Subero Edurne San José-Eneriz Leire Garate Sara Álvarez Estíbaliz Miranda Paula Rodríguez-Otero José Rifón Antonio Torres María José Calasanz Juan Cruz Cigudosa José Román-Gómez Felipe Prósper

PLoS One 2011 Feb 28;6(2):e17012. Epub 2011 Feb 28.

Hematology Service and Area of Cell Therapy, Clínica Universidad de Navarra, Foundation for Applied Medical Research, University of Navarra, Pamplona, Spain.

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February 2011

Epigenetic regulation of the non-canonical Wnt pathway in acute myeloid leukemia.

Authors:
Vanesa Martín Ana Valencia Xabier Agirre Jose Cervera Edurne San Jose-Eneriz Amaia Vilas-Zornoza Paula Rodriguez-Otero Miguel A Sanz Concepción Herrera Antonio Torres Felipe Prosper Jose Román-Gómez

Cancer Sci 2010 Feb 29;101(2):425-32. Epub 2009 Oct 29.

Hematology Department, Cellular Therapy Area, Reina Sofia Hospital, Maimonides Institute for Biomedical Research, Cordoba, Spain.

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February 2010

MicroRNA expression profiling in Imatinib-resistant Chronic Myeloid Leukemia patients without clinically significant ABL1-mutations.

Authors:
Edurne San José-Enériz José Román-Gómez Antonio Jiménez-Velasco Leire Garate Vanesa Martin Lucia Cordeu Amaia Vilas-Zornoza Paula Rodríguez-Otero María José Calasanz Felipe Prósper Xabier Agirre

Mol Cancer 2009 Sep 1;8:69. Epub 2009 Sep 1.

Foundation for Applied Medical Research, Division of Cancer, Area of Cell Therapy and Hematology Service, Clínica Universitaria, Universidad de Navarra, Spain.

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September 2009

Epigenetic silencing of the tumor suppressor microRNA Hsa-miR-124a regulates CDK6 expression and confers a poor prognosis in acute lymphoblastic leukemia.

Authors:
Xabier Agirre Amaia Vilas-Zornoza Antonio Jiménez-Velasco José Ignacio Martin-Subero Lucia Cordeu Leire Gárate Edurne San José-Eneriz Gloria Abizanda Paula Rodríguez-Otero Puri Fortes José Rifón Eva Bandrés María José Calasanz Vanesa Martín Anabel Heiniger Antonio Torres Reiner Siebert José Román-Gomez Felipe Prósper

Cancer Res 2009 May 12;69(10):4443-53. Epub 2009 May 12.

Hematology Department and Area of Cell Therapy, Clinica Universitaria and Division of Gene Therapy and Hepatology, Foundation for Applied Medical Research, University of Navarra, Pamplona, Spain.

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May 2009

Epigenetic down-regulation of BIM expression is associated with reduced optimal responses to imatinib treatment in chronic myeloid leukaemia.

Authors:
Edurne San José-Eneriz Xabier Agirre Antonio Jiménez-Velasco Lucia Cordeu Vanesa Martín Victor Arqueros Leire Gárate Vicente Fresquet Francisco Cervantes José A Martínez-Climent Anabel Heiniger Antonio Torres Felipe Prósper Jose Roman-Gomez

Eur J Cancer 2009 Jul 4;45(10):1877-89. Epub 2009 May 4.

Hematology Department and Area of Cell Therapy, Clinica Universitaria, Foundation for Applied Medical Research, University of Navarra, Pamplona, Spain.

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July 2009

Epigenetic regulation of microRNAs in acute lymphoblastic leukemia.

Authors:
Jose Roman-Gomez Xabier Agirre Antonio Jiménez-Velasco Victor Arqueros Amaia Vilas-Zornoza Paula Rodriguez-Otero Iñaki Martin-Subero Leire Garate Lucia Cordeu Edurne San José-Eneriz Vanesa Martin Juan Antonio Castillejo Eva Bandrés María José Calasanz Reiner Siebert Anabel Heiniger Antonio Torres Felipe Prosper

J Clin Oncol 2009 Mar 21;27(8):1316-22. Epub 2009 Jan 21.

Hematology Department. Reina Sofia Hospital. Avda. Menendez Pidal s/n. 14004 Cordoba. Spain.

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March 2009

Down-regulation of hsa-miR-10a in chronic myeloid leukemia CD34+ cells increases USF2-mediated cell growth.

Authors:
Xabier Agirre Antonio Jiménez-Velasco Edurne San José-Enériz Leire Garate Eva Bandrés Lucia Cordeu Oscar Aparicio Borja Saez Germán Navarro Amaia Vilas-Zornoza Ignacio Pérez-Roger Jesús García-Foncillas Antonio Torres Anabel Heiniger María José Calasanz Puri Fortes José Román-Gómez Felipe Prósper

Mol Cancer Res 2008 Dec;6(12):1830-40

Foundation for Applied Medical Research, Division of Cancer, Clínica Universitaria, University of Navarre, Pamplona, Spain.

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December 2008

Characterization of the paracrine effects of human skeletal myoblasts transplanted in infarcted myocardium.

Authors:
Maitane Perez-Ilzarbe Onnik Agbulut Beatriz Pelacho Cristina Ciorba Edurne San Jose-Eneriz Michel Desnos Albert A Hagège Pablo Aranda Enrique J Andreu Philippe Menasché Felipe Prósper

Eur J Heart Fail 2008 Nov 20;10(11):1065-72. Epub 2008 Sep 20.

Hematology, Cardiology and Cell Therapy, Clínica Universitaria and Division of Cancer, Foundation for Applied Medical Research, Division of Cancer, University of Navarra, Pamplona, Spain.

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November 2008

Methylation status of Wnt signaling pathway genes affects the clinical outcome of Philadelphia-positive acute lymphoblastic leukemia.

Authors:
Vanesa Martin Xabier Agirre Antonio Jiménez-Velasco Edurne San José-Eneriz Lucia Cordeu Leire Gárate Amaia Vilas-Zornoza Juan A Castillejo Anabel Heiniger Felipe Prósper Antonio Torres Jose Roman-Gomez

Cancer Sci 2008 Sep 28;99(9):1865-8. Epub 2008 Jun 28.

Hematology Department, Reina Sofia Hospital, 14004-Cordoba, Spain.

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September 2008

BCR-ABL1-induced expression of HSPA8 promotes cell survival in chronic myeloid leukaemia.

Authors:
Edurne San José-Enériz José Román-Gómez Lucia Cordeu Esteban Ballestar Leire Gárate Enrique J Andreu Isabel Isidro Elizabeth Guruceaga Antonio Jiménez-Velasco Anabel Heiniger Antonio Torres Maria José Calasanz Manel Esteller Norma C Gutiérrez Angel Rubio Ignacio Pérez-Roger Xabier Agirre Felipe Prósper

Br J Haematol 2008 Aug 5;142(4):571-82. Epub 2008 Jun 5.

Foundation for Applied Medical Research, Division of Cancer, Area of Cell Therapy and Haematology Service, Clínica Universitaria, Universidad de Navarra, Spain.

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August 2008