Publications by authors named "Eduardo J Villablanca"

54Publications

Lysophosphatidic Acid-Mediated GPR35 Signaling in CX3CR1 Macrophages Regulates Intestinal Homeostasis.

Cell Rep 2020 Aug;32(5):107979

Department of Biomedicine, University of Basel, 4031 Basel, Switzerland; University Center for Gastrointestinal and Liver Diseases, St. Clara Hospital and University Hospital of Basel, 4031 Basel, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2020.107979DOI Listing
August 2020

Liver X receptor regulates Th17 and RORγt Treg cells by distinct mechanisms.

Mucosal Immunol 2020 Jul 17. Epub 2020 Jul 17.

Division of Immunology and Allergy, Department of Medicine, Solna, Karolinska Institutet and University Hospital, Stockholm, Sweden.

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http://dx.doi.org/10.1038/s41385-020-0323-5DOI Listing
July 2020

Neutrophilic HGF-MET signaling exacerbates intestinal inflammation.

J Crohns Colitis 2020 Jun 17. Epub 2020 Jun 17.

Department of Chronic Diseases, Metabolism and Ageing (CHROMETA), Translational Research Center for Gastrointestinal Disorders (TARGID), KU Leuven, 3000 Leuven, Belgium.

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http://dx.doi.org/10.1093/ecco-jcc/jjaa121DOI Listing
June 2020

Retinoic acid induced cytokines are selectively modulated by liver X receptor activation in zebrafish.

Reprod Toxicol 2020 04 25;93:163-168. Epub 2020 Feb 25.

Division of Immunology and Allergy, Department of Medicine, Solna, Karolinska Institutet and University Hospital, 17176, Stockholm, Sweden; Center of Molecular Medicine, 17176, Stockholm, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.reprotox.2020.02.009DOI Listing
April 2020

The Cell Circuitry of Ulcerative Colitis, a New View for a Highly Complex Disease.

Gastroenterology 2020 04 15;158(5):1506-1508. Epub 2020 Feb 15.

Division of Immunology and Allergy, Center of Molecular Medicine, Department of Medicine, 17176 Karolinska Institutet and University Hospital, Stockholm, Sweden.

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http://dx.doi.org/10.1053/j.gastro.2020.02.019DOI Listing
April 2020

Conserved transcriptomic profile between mouse and human colitis allows unsupervised patient stratification.

Nat Commun 2019 06 28;10(1):2892. Epub 2019 Jun 28.

Immunology and Allergy Unit, Department of Medicine, Solna, Karolinska Institute and University Hospital, 17176, Stockholm, Sweden.

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http://dx.doi.org/10.1038/s41467-019-10769-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6598981PMC
June 2019

Dietary Habits and Intestinal Immunity: From Food Intake to CD4 T Cells.

Front Immunol 2018 15;9:3177. Epub 2019 Jan 15.

Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

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http://dx.doi.org/10.3389/fimmu.2018.03177DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340974PMC
October 2019

Multi-faceted inhibition of dendritic cell function by CD4Foxp3 regulatory T cells.

J Autoimmun 2019 03 5;98:86-94. Epub 2019 Jan 5.

Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.jaut.2018.12.002DOI Listing
March 2019

Commensal Bacteria-Specific CD4 T Cell Responses in Health and Disease.

Front Immunol 2018 20;9:2667. Epub 2018 Nov 20.

Immunology and Allergy Unit, Department of Medicine Solna, Karolinska Institute, Stockholm, Sweden.

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https://www.frontiersin.org/article/10.3389/fimmu.2018.02667
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http://dx.doi.org/10.3389/fimmu.2018.02667DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6256970PMC
October 2019

β7 integrins contribute to intestinal tumor growth in mice.

PLoS One 2018 20;13(9):e0204181. Epub 2018 Sep 20.

Department of Medicine, Solna, Science for Life Laboratory, Karolinska Institute and University Hospital, Stockholm, Sweden.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0204181PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6147474PMC
March 2019

T17 cell plasticity: The role of dendritic cells and molecular mechanisms.

J Autoimmun 2018 02 19;87:50-60. Epub 2018 Jan 19.

Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany; I. Department of Medicine, University Medical Center Hamburg-Eppendorf Hamburg-Eppendorf, 20246 Hamburg, Germany; Immunology and Allergy Unit, Department of Medicine Solna, Karolinska Institute, 17176 Stockholm, Sweden. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S08968411173078
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http://dx.doi.org/10.1016/j.jaut.2017.12.003DOI Listing
February 2018

Vitamin D downregulates the IL-23 receptor pathway in human mucosal group 3 innate lymphoid cells.

J Allergy Clin Immunol 2018 01 20;141(1):279-292. Epub 2017 Apr 20.

Center for Infectious Medicine, Department of Medicine, Huddinge, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden; Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00916749173065
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http://dx.doi.org/10.1016/j.jaci.2017.01.045DOI Listing
January 2018

Retinoic Acid and Its Role in Modulating Intestinal Innate Immunity.

Nutrients 2017 Jan 13;9(1). Epub 2017 Jan 13.

Immunology and Allergy Unit, Department of Medicine, Solna, Karolinska Institutet and University Hospital, Stockholm 171-76, Sweden.

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http://dx.doi.org/10.3390/nu9010068DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5295112PMC
January 2017

Genetic Coding Variant in GPR65 Alters Lysosomal pH and Links Lysosomal Dysfunction with Colitis Risk.

Immunity 2016 06 7;44(6):1392-405. Epub 2016 Jun 7.

The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, MA 02114, USA; Gastrointestinal Unit, Massachusetts General Hospital, Boston, MA 02114, USA; Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Boston, MA 02114, USA. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2016.05.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4936415PMC
June 2016

Mechanisms of Pediatric Inflammatory Bowel Disease.

Annu Rev Immunol 2016 05;34:31-64

Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease and.

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http://dx.doi.org/10.1146/annurev-immunol-032414-112151DOI Listing
May 2016

Breast Milk and Solid Food Shaping Intestinal Immunity.

Front Immunol 2015 19;6:415. Epub 2015 Aug 19.

Translational Immunology Unit, Department of Medicine Solna, Karolinska Institutet and University Hospital , Stockholm , Sweden.

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http://dx.doi.org/10.3389/fimmu.2015.00415DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4541369PMC
September 2015

Integrated Genomics of Crohn's Disease Risk Variant Identifies a Role for CLEC12A in Antibacterial Autophagy.

Cell Rep 2015 Jun 18;11(12):1905-18. Epub 2015 Jun 18.

Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Boston, MA 02114, USA; Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, MA 02114, USA; The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.05.045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4507440PMC
June 2015

Atg16L1 T300A variant decreases selective autophagy resulting in altered cytokine signaling and decreased antibacterial defense.

Proc Natl Acad Sci U S A 2014 May 12;111(21):7741-6. Epub 2014 May 12.

Broad Institute, Cambridge, MA 02142;Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, MA 02114;Gastrointestinal Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114;Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Boston, MA 02114;

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http://dx.doi.org/10.1073/pnas.1407001111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4040621PMC
May 2014

β7 integrins are required to give rise to intestinal mononuclear phagocytes with tolerogenic potential.

Gut 2014 Sep 12;63(9):1431-40. Epub 2013 Sep 12.

Gastrointestinal Unit, Massachusetts General Hospital & Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1136/gutjnl-2013-305386DOI Listing
September 2014

Atg16l1 is required for autophagy in intestinal epithelial cells and protection of mice from Salmonella infection.

Gastroenterology 2013 Dec 21;145(6):1347-57. Epub 2013 Aug 21.

Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts; Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts; Center for Computational and Integrative Biology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1053/j.gastro.2013.08.035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3840157PMC
December 2013

Retinoic acid-producing DCs and gut-tropic FOXP3 regulatory T cells in the induction of oral tolerance.

Oncoimmunology 2013 Feb;2(2):e22987

Gastrointestinal Unit; Massachusetts General Hospital/Harvard Medical School; Boston, MA USA.

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http://dx.doi.org/10.4161/onci.22987DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3601169PMC
February 2013

FcγRI (CD64): an identity card for intestinal macrophages.

Eur J Immunol 2012 Dec;42(12):3136-40

Gastrointestinal Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1002/eji.201243061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3644030PMC
December 2012

Wiskott-Aldrich syndrome protein deficiency in innate immune cells leads to mucosal immune dysregulation and colitis in mice.

Gastroenterology 2012 Sep 15;143(3):719-729.e2. Epub 2012 Jun 15.

Gastrointestinal Unit and the Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Boston, Massachusetts; Harvard Medical School, Boston, Massachusetts; Department of Gastroenterology/Nutrition, Children's Hospital, Boston, Massachusetts; Division of Gastroenterology, Brigham and Women's Hospital, Boston, Massachusetts. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2012.06.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3760724PMC
September 2012

Vitamin A and immune regulation: role of retinoic acid in gut-associated dendritic cell education, immune protection and tolerance.

Mol Aspects Med 2012 Feb 22;33(1):63-76. Epub 2011 Nov 22.

Gastrointestinal Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.

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http://dx.doi.org/10.1016/j.mam.2011.11.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3246074PMC
February 2012

T-cell homing to the gut mucosa: general concepts and methodological considerations.

Methods Mol Biol 2012 ;757:411-34

Gastrointestinal Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1007/978-1-61779-166-6_24DOI Listing
January 2012

Vitamin A deficiency impairs vaccine-elicited gastrointestinal immunity.

J Immunol 2011 Aug 15;187(4):1877-83. Epub 2011 Jul 15.

Division of Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.

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http://dx.doi.org/10.4049/jimmunol.1101248DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3150351PMC
August 2011

Blocking lymphocyte localization to the gastrointestinal mucosa as a therapeutic strategy for inflammatory bowel diseases.

Gastroenterology 2011 May;140(6):1776-84

Gastrointestinal Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1053/j.gastro.2011.02.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3102304PMC
May 2011

Competitive homing assays to study gut-tropic t cell migration.

J Vis Exp 2011 Mar 1(49). Epub 2011 Mar 1.

Gastrointestinal Unit, Massachusetts General Hospital, Harvard Medical School, USA.

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http://dx.doi.org/10.3791/2619DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3197317PMC
March 2011

Molecular dissection of the migrating posterior lateral line primordium during early development in zebrafish.

BMC Dev Biol 2010 Dec 13;10:120. Epub 2010 Dec 13.

Center for Genome Regulation. Facultad de Ciencias, Universidad de Chile, Casilla 653. Santiago, Chile.

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http://dx.doi.org/10.1186/1471-213X-10-120DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3016277PMC
December 2010

Gut homing receptors on CD8 T cells are retinoic acid dependent and not maintained by liver dendritic or stellate cells.

Gastroenterology 2009 Jul 21;137(1):320-9. Epub 2009 Feb 21.

MRC Centre for Immune Regulation, Institute for Biomedical Research, Medical School, University of Birmingham, Birmingham, United Kingdom.

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http://dx.doi.org/10.1053/j.gastro.2009.02.046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3201985PMC
July 2009

A two-step model for Langerhans cell migration to skin-draining LN.

Eur J Immunol 2008 Nov;38(11):2975-80

Department of Medicine, Gastrointestinal Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.

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http://doi.wiley.com/10.1002/eji.200838919
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http://dx.doi.org/10.1002/eji.200838919DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3204458PMC
November 2008

Selected natural and synthetic retinoids impair CCR7- and CXCR4-dependent cell migration in vitro and in vivo.

J Leukoc Biol 2008 Sep 30;84(3):871-9. Epub 2008 May 30.

Cancer Gene Therapy Unit, Cancer Immunotherapy and Gene Therapy Program, Scientific Institute H. San Raffaele, Milan, Italy.

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http://doi.wiley.com/10.1189/jlb.0108047
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http://dx.doi.org/10.1189/jlb.0108047DOI Listing
September 2008

Dendritic cell migration and lymphocyte homing imprinting.

Histol Histopathol 2008 07;23(7):897-910

Cancer Gene Therapy Unit, Scientific Institute H. San Raffaele, San Raffaele, Milan, Italy.

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http://dx.doi.org/10.14670/HH-23.897DOI Listing
July 2008

Abrogation of prostaglandin E2/EP4 signaling impairs the development of rag1+ lymphoid precursors in the thymus of zebrafish embryos.

J Immunol 2007 Jul;179(1):357-64

Cancer Gene Therapy Unit, Cancer Immunotherapy and Gene Therapy Program, Scientific Institute H. San Raffaele, Via Olgettina 58, Milan, Italy.

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http://dx.doi.org/10.4049/jimmunol.179.1.357DOI Listing
July 2007

Proneural gene requirement for hair cell differentiation in the zebrafish lateral line.

Dev Biol 2006 Jul 4;295(2):534-45. Epub 2006 Apr 4.

Millennium Nucleus in Developmental Biology, Departamento de Biología, Facultad de Ciencias, Universidad de Chile, Casilla 653, Santiago, Chile.

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http://dx.doi.org/10.1016/j.ydbio.2006.03.037DOI Listing
July 2006