Dr. Eduardo Anglés-Cano, MD, ScD, PhD - Inserm/Université Paris Descartes - Director of Research

Dr. Eduardo Anglés-Cano

MD, ScD, PhD

Inserm/Université Paris Descartes

Director of Research

Paris | France

Main Specialties: Hematology

Additional Specialties: Haemostasis-Thrombosis

ORCID logohttps://orcid.org/0000-0001-7891-3975


Top Author

Dr. Eduardo Anglés-Cano, MD, ScD, PhD - Inserm/Université Paris Descartes - Director of Research

Dr. Eduardo Anglés-Cano

MD, ScD, PhD

Introduction

We are pioneer in the study of fibrinolytic microvesicles (MVs) as functional messengers of plasmin generation. MVs derived from cells that express plasminogen activators may generate, disseminate and transfer plasmin proteolytic activity (Blood, 2007). For instance, besides endothelial cells and leucocytes, neurons are able to release microvesicles bearing plasmin and tPA activity (Biochem J 2010). We have found that endothelial cell- and leucocyte- derived microvesicles bear the machinery necessary for plasmin formation including plasminogen activators and its receptors: tPA for endothelial MVs and the uPA/uPAR system for leukocyte MVs (Haematologica 2013). Presently, we are prospecting on synthetic tools to identify phosphatidylserine on cell membranes.
Furthermore, we have discovered a new mechanism for plasmin formation that bypass the requirement for co-assembly of plasminogen and uPA on the same surface (Blood 2010). These heterotypic cell-to-cell (platelets/ monocytes; platelets/MPs), cell-to-matrix (leukocytes/fibrin), or MPs-to-matrix (MPs/fibrin) proteolytic cross-talk represents an alternative pathway for localized plasmin formation that may be relevant not only for fibrinolysis, but also for processes such as cell migration and MP dissemination. Finally, our data provide additional evidence for a novel role of MPs and platelets, as vectors that generate and propagate plasmin fibrinolytic and/or proteolytic activity, and could thereby constitute a pharmacologic tool.
At the Inserm reaserch unit UMR_S 1140 (Faculty of pharmaceutical and biological sciences, Paris) we have studied the fibrinolytic and microvesiculation properties of human bone marrow mesenchymal stem cells (submitted). Our translational research is mainly related to the role of NET transformation of PMN on the fibrinolytic response to ischaemic diseases.

Primary Affiliation: Inserm/Université Paris Descartes - Paris , France

Specialties:

Additional Specialties:

Research Interests:


View Dr. Eduardo Anglés-Cano’s Resume / CV

Education

Jul 1980
University of Paris
Sc.D.
Jul 1978
University of Paris
Ph. D.
Jul 1978
University of Paris
Ph. D.
Jan 1975
Faculty of Medicine UNAM
M.D.
Jan 1975
Faculty of Medicine UNAM
M.D.
Jan 1975
Faculty of Medicine UNAM
M.D.

Experience

Aug 2008
INSERM
Emeritus Director of Research
UMR_S 1140

Publications

124Publications

555Reads

333Profile Views

406PubMed Central Citations

Evidence of Netosis in Septic Shock-Induced Disseminated Intravascular Coagulation.

Shock 2017 03;47(3):313-317

*Medical Intensive Care Unit, NHC - Strasbourg University Hospital, Strasbourg, France †EA 7293 FMTS, University of Strasbourg, Strasbourg, France ‡Laboratory of Medical Biostatistics and Informatics, University of Strasbourg, Strasbourg, France §Group Method in Clinical Research, Public Health Unit, Strasbourg University Hospital, Strasbourg, France ||Hematology and heamostasis laboratory, Hautepierre - Strasbourg University Hospital, Strasbourg, France ¶EA 3430 FMTS, University of Strasbourg, Strasbourg, France #EA 7290, University of Strasbourg, Strasbourg, France **CNRS UMR 7213, University of Strasbourg, Illkirch, France ††Paris Descartes University, Sorbonne, Paris, France ‡‡INSERM UMR S1140, Paris, France.

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http://dx.doi.org/10.1097/SHK.0000000000000719DOI Listing
March 2017
13 Reads
12 Citations
3.045 Impact Factor

Exome Sequencing and Clot Lysis Experiments Demonstrate the R458C Mutation of the Alpha Chain of Fibrinogen to be Associated with Impaired Fibrinolysis in a Family with Thrombophilia.

J Atheroscler Thromb 2016 17;23(4):431-40. Epub 2015 Nov 17.

Stroke pharmacogenomics and genetics laboratory, Fundació Docencia i Recerca MutuaTerrassa, Hospital Mutua de Terrassa.

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http://dx.doi.org/10.5551/jat.30676DOI Listing
January 2017
11 Reads
1 Citation
2.733 Impact Factor

Endothelial fibrinolytic response onto an evolving matrix of fibrin.

BMC Hematol 2016 14;16. Epub 2016 Apr 14.

Centro de Medicina Experimental, Laboratorio Biología del Desarrollo de la Hemostasia, Instituto Venezolano de Investigaciones Científicas, Caracas, República Bolivariana de Venezuela.

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http://dx.doi.org/10.1186/s12878-016-0048-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4831191PMC
April 2016
1 Read

Evidence for several independent genetic variants affecting lipoprotein (a) cholesterol levels.

Hum Mol Genet 2015 Apr 9;24(8):2390-400. Epub 2015 Jan 9.

Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, MD 21201, USA,

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http://dx.doi.org/10.1093/hmg/ddu731DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4380064PMC
April 2015
14 Reads
16 Citations
6.393 Impact Factor

Molecular requirements for safer generation of thrombolytics by bioengineering the tissue-type plasminogen activator A chain.

J Thromb Haemost 2013 Mar;11(3):539-46

Inserm, Inserm UMR-S U919, University of Caen Basse-Normandie, Serine Proteases and Pathophysiology of Neurovascular Unit, GIP Cyceron, Caen, France.

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http://dx.doi.org/10.1111/jth.12128DOI Listing
March 2013
1 Read

Unveiling an exceptional zymogen: the single-chain form of tPA is a selective activator of NMDA receptor-dependent signaling and neurotoxicity.

Cell Death Differ 2012 Dec 29;19(12):1983-91. Epub 2012 Jun 29.

Inserm U919, Serine Proteases and Pathophysiology of the neurovascular Unit, Université de Caen Basse-Normandie, GIP Cyceron, Caen, France.

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http://dx.doi.org/10.1038/cdd.2012.86DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3504712PMC
December 2012
1 Read
8.184 Impact Factor

Lipoprotein(a) and homocysteine potentiate the risk of coronary artery disease in male subjects.

Circ J 2012 18;76(8):1953-7. Epub 2012 May 18.

Instituto Nacional de Cardiología Ignacio Chávez, Grupo Genética Intervencionista, Departamentos de Biología Molecular, Hemodinámica, Endocrinología, Unidad Coronaria, Juan Badiano 1, México.

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December 2012
9 Reads
2 Citations
3.940 Impact Factor

Synergistic effect of thrombin and CD40 ligand on endothelial matrix metalloproteinase-10 expression and microparticle generation in vitro and in vivo.

Arterioscler Thromb Vasc Biol 2012 Jun 5;32(6):1477-87. Epub 2012 Apr 5.

Laboratory of Atherothrombosis, Division of Cardiovascular Sciences, CIMA, Av. Pio XII, 55, 31008 Pamplona, Navarra, Spain.

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http://dx.doi.org/10.1161/ATVBAHA.112.248773DOI Listing
June 2012
12 Reads
16 Citations
6.000 Impact Factor

Matrix metalloproteinase-10 effectively reduces infarct size in experimental stroke by enhancing fibrinolysis via a thrombin-activatable fibrinolysis inhibitor-mediated mechanism.

Circulation 2011 Dec 21;124(25):2909-19. Epub 2011 Nov 21.

Laboratory of Atherosclerosis, Division of Cardiovascular Science, CIMA, Avenida Pio XII, 55, 31008 Pamplona, Navarra, Spain.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.111.047100DOI Listing
December 2011
3 Reads
14.430 Impact Factor

Plasmin on adherent cells: from microvesiculation to apoptosis.

Biochem J 2010 Dec;432(2):365-73

Inserm U919, GiP Cyceron, Bd Henri Becquerel, 14074 Caen, France.

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http://dx.doi.org/10.1042/BJ20100561DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3124466PMC
December 2010
8 Reads
11 Citations
4.400 Impact Factor

Sizing nanomatter in biological fluids by fluorescence single particle tracking.

Nano Lett 2010 Nov 5;10(11):4435-42. Epub 2010 Oct 5.

Laboratory of General Biochemistry and Physical Pharmacy, Ghent University, Harelbekestraat 72, 9000 Gent, Belgium.

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http://dx.doi.org/10.1021/nl103264uDOI Listing
November 2010
12 Reads
12 Citations
13.592 Impact Factor

Apo(a) phenotyping and long-term prognosis for coronary artery disease.

Clin Biochem 2010 May 12;43(7-8):640-4. Epub 2010 Feb 12.

Instituto Nacional de Cardiología "Ignacio Chávez", Departamentos de Biología Molecular, Mexico, D.F.

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http://dx.doi.org/10.1016/j.clinbiochem.2010.01.013DOI Listing
May 2010
1 Read
2.229 Impact Factor

Plasmin induces apoptosis of aortic valvular myofibroblasts.

J Pathol 2010 May;221(1):37-48

Inserm, UMR698, Hemostasis, Bio-Engineering and Cardiovascular Remodelling, Paris 7 Denis Diderot University, Hôpital Bichat-Claude Bernard, 46 Rue Henri Huchard, 75877 Paris Cedex 18, France.

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http://dx.doi.org/10.1002/path.2681DOI Listing
May 2010
5 Reads
4 Citations
7.430 Impact Factor

Role of plasminogen activation in neuronal organization and survival.

Mol Cell Neurosci 2009 Dec 14;42(4):288-95. Epub 2009 Aug 14.

Inserm U698, Université Paris Diderot-Paris 7, 75018 Paris, France.

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http://dx.doi.org/10.1016/j.mcn.2009.08.001DOI Listing
December 2009
3 Reads
12 Citations
3.840 Impact Factor

[Cellular microparticles, potential useful biomarkers in the identification of cerebrovascular accidents].

Med Sci (Paris) 2009 Oct;25(10):843-6

Inserm U919, Sérine protéases et physiopathologie de l'unité neurovasculaire, UMR-CNRS 6232 CINAPS, Cyceron, Caen, F-14074 France.

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http://dx.doi.org/10.1051/medsci/20092510843DOI Listing
October 2009
8 Reads
1 Citation
0.520 Impact Factor

[Cerebral ischemia (2), How to neutralize the neurotoxic effects of tPA].

Med Sci (Paris) 2009 Oct;25(10):855-7

Inserm U919, Sérine protéases et physiopathologie de l'unité neurovasculaire, UMR-CNRS 6232 CINAPS, Cyceron, F-14074 Caen, France.

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http://dx.doi.org/10.1051/medsci/20092510855DOI Listing
October 2009
38 Reads
1 Citation
0.520 Impact Factor

Cell-derived microparticles: a new challenge in neuroscience.

J Neurochem 2009 Jul 13;110(2):457-68. Epub 2009 May 13.

INSERM U, Université de Caen, France.

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http://dx.doi.org/10.1111/j.1471-4159.2009.06163.xDOI Listing
July 2009
1 Read
16 Citations
4.281 Impact Factor

[Cell-derived microparticles unveil their fibrinolytic and proteolytic function].

Med Sci (Paris) 2009 Jan;25(1):37-44

Inserm U919, Sérine Protéases et Physiopathologie de l'Unité neurovasculaire, CiNaps, UMR CNRS 6232, GIP Cyceron, boulevard Henri Becquerel, 14074 Caen Cedex, France.

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http://dx.doi.org/10.1051/medsci/200925137DOI Listing
January 2009
2 Reads
2 Citations
0.520 Impact Factor

Relationship between apo(a) length polymorphism and lipoprotein(a) concentration in healthy Ivorian subjects with single or double apo(a) isoforms.

Clin Biochem 2008 Sep 12;41(13):1039-43. Epub 2008 Jun 12.

Laboratory of Biochemistry, UFR Pharmaceutical and Biological Sciences, Abidjan, Côte d'Ivoire.

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http://dx.doi.org/10.1016/j.clinbiochem.2008.05.014DOI Listing
September 2008
7 Reads
2.230 Impact Factor

[Immunoquantification of serum lipoprotein(a) in healthy Ivorian subject: a comparative evaluation of two methods].

Ann Biol Clin (Paris) 2007 Nov-Dec;65(6):629-35

Laboratoire de biochimie, UFR de sciences pharmaceutiques et biologiques, Abidjan, Ivory Coast.

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March 2008
1 Read
0.415 Impact Factor

Mouse model of in situ thromboembolic stroke and reperfusion.

Stroke 2007 Oct 16;38(10):2771-8. Epub 2007 Aug 16.

INSERM-Avenir tPA in the working brain, University of Caen, Centre CYCERON, Bd Becquerel, BP 5229, 14074 Caen Cedex, France.

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http://dx.doi.org/10.1161/STROKEAHA.107.487520DOI Listing
October 2007
3 Reads
48 Citations
5.723 Impact Factor

Activation of plasminogen into plasmin at the surface of endothelial microparticles: a mechanism that modulates angiogenic properties of endothelial progenitor cells in vitro.

Blood 2007 Oct 2;110(7):2432-9. Epub 2007 Jul 2.

Unité Mixte de Recherche S 608 (UMR-S 608), Institut National de la Santé et de la Recherche Médicale (INSERM), Université de la Méditerranée, Unité de Formation et de Recherche (UFR) de Pharmacie, Marseille, France.

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http://dx.doi.org/10.1182/blood-2007-02-069997DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2495018PMC
October 2007
9 Reads
43 Citations
10.452 Impact Factor

A case of afibrinogenemia associated with A-alpha chain gene compound heterozygosity (HUMFIBRA c.[4110delA]+[3200+1G>T]).

Blood Coagul Fibrinolysis 2007 Jan;18(1):73-5

Inserm U698, Université Paris7-Denis Diderot, Paris, France.

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http://dx.doi.org/10.1097/MBC.0b013e328010bd16DOI Listing
January 2007
8 Reads
1 Citation
1.380 Impact Factor

Lipoprotein(a) in the cerebrospinal fluid of neurological patients with blood-cerebrospinal fluid barrier dysfunction.

Clin Chem 2006 Nov 21;52(11):2043-8. Epub 2006 Sep 21.

Department of Biochemistry and Molecular Biology, University of Bari, Italy.

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http://dx.doi.org/10.1373/clinchem.2006.073544DOI Listing
November 2006
4 Reads
2 Citations
7.911 Impact Factor

Plasminogen activator inhibitor-1 impairs plasminogen activation-mediated vascular smooth muscle cell apoptosis.

Thromb Haemost 2006 Nov;96(5):665-70

Center for Molecular and Vascular Biology, K.U.Leuven, Leuven, Belgium.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2237888PMC
November 2006
4 Reads
10 Citations
4.984 Impact Factor

Interaction of fibrin(ogen) with apolipoprotein(a): further characterization and identification of a novel lysine-dependent apolipoprotein(a)-binding site within the gamma chain 287-411 region.

Biochemistry 2006 Sep;45(35):10624-32

Center for Vascular and Inflammatory Diseases and Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA.

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http://dx.doi.org/10.1021/bi060526hDOI Listing
September 2006
4 Reads
2 Citations
3.020 Impact Factor

Functional characterization of fibrinogen Bicêtre II: a gamma 308 Asn-->Lys mutation located near the fibrin D:D interaction sites.

Blood Coagul Fibrinolysis 2006 Apr;17(3):193-201

Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1097/01.mbc.0000220241.22714.68DOI Listing
April 2006
3 Reads
3 Citations
1.380 Impact Factor

Dual effect of apolipoprotein(a) on plasmin(ogen)-induced apoptosis through modulation of cell detachment of adherent cells.

Thromb Haemost 2006 Jan;95(1):142-50

INSERM U698, Paris 18, France.

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January 2006
3 Reads
4.984 Impact Factor

Functional hierarchy of plasminogen kringles 1 and 4 in fibrinolysis and plasmin-induced cell detachment and apoptosis.

FEBS J 2005 Jul;272(13):3387-400

INSERM U698, Centre Hospitalier Universitaire Bichat-Claude Bernard, Paris, France.

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http://dx.doi.org/10.1111/j.1742-4658.2005.04754.xDOI Listing
July 2005
22 Reads
8 Citations
4.001 Impact Factor

Mechanism for the homocysteine-enhanced antifibrinolytic potential of lipoprotein(a) in human plasma.

Thromb Haemost 2005 Jul;94(1):75-81

INSERM U698, CHU Bichat-Claude Bernard, 46 rue Henri Huchard, F-75877-Cdx, Paris 18, France.

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http://dx.doi.org/10.1160/TH04-12-0808DOI Listing
July 2005
1 Read
1 Citation
4.984 Impact Factor

The plasminogen-MMP system is more activated in the scar than in viable myocardium 3 months post-MI in the rat.

J Mol Cell Cardiol 2005 Jan 9;38(1):193-204. Epub 2004 Dec 9.

Inserm U460, Cardiovascular Remodeling, CHU Xavier Bichat-Claude Bernard, 46, rue Henri Huchard, 75877 Paris cedex 18, France.

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http://dx.doi.org/10.1016/j.yjmcc.2004.10.017DOI Listing
January 2005
7 Reads
8 Citations
4.660 Impact Factor

Neutrophils stimulated by apolipoprotein(a) generate fragments that are stronger inhibitors of plasmin formation than apo(a).

Thromb Haemost 2004 Nov;92(5):1066-75

Department of Biochemistry & Molecular Biology & IBBE-CNR, University of Bari, Italy.

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http://dx.doi.org/10.1160/TH04-04-0241DOI Listing
November 2004
2 Reads
2 Citations
4.984 Impact Factor

Protease nexin-1 inhibits plasminogen activation-induced apoptosis of adherent cells.

J Biol Chem 2004 Mar 29;279(11):10346-56. Epub 2003 Dec 29.

INSERM U460, Centre Hospitalier Universitaire Bichat-Claude Bernard, Paris 18, France.

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http://dx.doi.org/10.1074/jbc.M310964200DOI Listing
March 2004
4 Reads
26 Citations
4.573 Impact Factor

Identification and characterization of novel lysine-independent apolipoprotein(a)-binding sites in fibrin(ogen) alphaC-domains.

J Biol Chem 2003 Sep 9;278(39):37154-9. Epub 2003 Jul 9.

Jerome H. Holland Laboratory for the Biomedical Sciences, American Red Cross, Rockville, Maryland 20855, USA.

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http://dx.doi.org/10.1074/jbc.M305154200DOI Listing
September 2003
11 Reads
6 Citations
4.573 Impact Factor

Pericellular plasmin induces smooth muscle cell anoikis.

FASEB J 2003 Jul 8;17(10):1301-3. Epub 2003 May 8.

INSERM U460, CHU Bichat-Claude Bernard, 75018 Paris, France.

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http://dx.doi.org/10.1096/fj.02-0687fjeDOI Listing
July 2003
7 Reads
25 Citations
5.043 Impact Factor

Functional approach to investigate Lp(a) in ischaemic heart and cerebral diseases.

Eur J Clin Invest 2003 Feb;33(2):99-105

Instituto Nacional de Cardiología Ignacio Chávez, México.

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February 2003
1 Read
2.734 Impact Factor

Involvement of the mural thrombus as a site of protease release and activation in human aortic aneurysms.

Am J Pathol 2002 Nov;161(5):1701-10

Institut National de la Santé et de la Recherche Médicale U460, Cardiovascular Remodeling, Hôpital Xavier Bichat, Paris, France.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1850780PMC
http://dx.doi.org/10.1016/S0002-9440(10)64447-1DOI Listing
November 2002
14 Reads
48 Citations
4.591 Impact Factor

Bivalency of plasminogen monoclonal antibodies is required for plasminogen bridging to fibrin and enhanced plasmin formation.

Biochim Biophys Acta 2002 Jul;1598(1-2):165-76

Plasminogen Activation in Cardiovascular Remodelling, Institut National de la Santé et de la Recherche Médicale, INSERM U460, UFR de Médecine Xavier Bichat, 16 rue Henri Huchard-BP 416, Paris, France.

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July 2002
4 Reads
1 Citation

Lp(a) particles mold fibrin-binding properties of apo(a) in size-dependent manner: a study with different-length recombinant apo(a), native Lp(a), and monoclonal antibody.

Arterioscler Thromb Vasc Biol 2002 Jul;22(7):1232-8

INSERM U460, Faculté de Médecine Xavier Bichat, Paris, France.

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July 2002
4 Reads
6.000 Impact Factor

Plasminogen activation by blood monocytes and alveolar macrophages in primary pulmonary hypertension.

Blood Coagul Fibrinolysis 2002 Jul;13(5):417-22

UPRES EA 2705 Centre de Maladies Vasculaires Pulmonaires, Hôpital Antoine-Béclère, Clamart, France.

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July 2002
1 Read
1.380 Impact Factor

[Is lipoprotein (a) a risk factor in coronary atherothrombotic disease?].

Arch Cardiol Mex 2001 Jul-Sep;71(3):188-92

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June 2002
1 Read

[Physiopathology of aortic aneurysm].

Rev Prat 2002 May;52(10):1061-5

INSERM Unité 460 (Remodelage cardiovasculaire) Faculté de médecine Xavier Bichat B.P. 416 75870 Paris.

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May 2002
30 Reads
1 Citation

Apolipoprotein(a): structure-function relationship at the lysine-binding site and plasminogen activator cleavage site.

Biol Chem 2002 Jan;383(1):93-9

Institut National de la Santé et de la Recherche, Médicale, Faculté de Médecine Xavier-Bichat, Paris, France.

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http://dx.doi.org/10.1515/BC.2002.009DOI Listing
January 2002
8 Reads
3 Citations
3.270 Impact Factor

Experimental Study of Fibrin/Fibrin-Specific Molecular Interactions Using a Sphere/Plane Adhesion Model.

J Colloid Interface Sci 2001 Sep;241(1):52-62

Institut de Mécanique des Fluides de Toulouse, UMR CNRS 5502, Allée du Professeur C. Soula, Toulouse, 31400, France

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http://dx.doi.org/10.1006/jcis.2001.7679DOI Listing
September 2001
4 Reads
5 Citations
3.370 Impact Factor

Inhibition of fibrinolysis by lipoprotein(a).

Ann N Y Acad Sci 2001 ;936:261-75

Institut National de la Santé et de la Recherche Médicale, U460, Faculté de Médecine Xavier-Bichat, France.

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August 2001
2 Reads
4.313 Impact Factor

Structure and properties of clots from fibrinogen Bicêtre II (gamma 308 Asn-->Lys). Increased permeability due to larger pores, thicker fibers, and decreased rigidity.

Ann N Y Acad Sci 2001 ;936:125-8

Laboratorio de Fisiopatología, Centro de Medicina Experimental, IVIC, Caracas, Venezuela.

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August 2001
1 Read
4.313 Impact Factor

Antiphospholipid antibodies and the coagulation cascade.

Rheum Dis Clin North Am 2001 Aug;27(3):573-86

INSERM U.460, Remodelage Cardiovasculaire Faculté de Médecine Xavier-Bichat, Paris, France.

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August 2001
1 Read
2.692 Impact Factor

Elevated plasma tissue plasminogen activator and anti-THP-1 antibodies are independently associated with decreased graft survival in cardiac transplant recipients.

Am J Cardiol 2001 Jul;88(1):30-4

Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA.

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July 2001
1 Read
3.276 Impact Factor

Kringles of the plasminogen--prothrombin gene family share conformational epitopes with recombinant apolipoprotein (a): specificity of the fibrin-binding site.

Biochim Biophys Acta 2001 Jul;1548(1):72-80

Institut National de la Santé et de la Recherche Médicale, INSERM U.460, Plasminogen Activation in Cardiovascular Remodeling, Faculté Xavier Bichat, Paris, France.

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July 2001
1 Read

Binding of recombinant apolipoprotein(a) to human platelets and effect on platelet aggregation.

Thromb Haemost 2001 Apr;85(4):686-93

Unit of Hematology and Clinical Oncology, University General Hospital, Murcia, Spain.

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April 2001
1 Read
4.984 Impact Factor

Lipoprotein Lp(a) and atherothrombotic disease.

Arch Med Res 2000 Jul-Aug;31(4):353-9

Departamento de Hematología, Instituto Nacional de Cardiología Ignacio Chávez, México, D.F., Mexico.

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February 2001
2 Reads
2.406 Impact Factor

High antifibrinolytic activity of lipoprotein(a) containing small apolipoprotein(a) isoforms.

Authors:
E Anglés-Cano

Circulation 2000 Dec;102(25):E184-5

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December 2000
1 Read
14.430 Impact Factor

Antibodies to tissue-type plasminogen activator in plasma from patients with primary antiphospholipid syndrome.

Br J Haematol 2000 Mar;108(4):871-5

Department of Internal Medicine, IRCCS Maggiore Hospital, University of Milan, Milan, Italy. massimo.cugno.unimi.it

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March 2000
2 Reads
4.711 Impact Factor

Immobilisation of monocytes to a solid support: a model for the study of ligand-binding interactions and plasminogen activation at the cell surface.

Thromb Res 1999 Dec;96(6):473-80

INSERM U.143 Hémostase-Biologie Vasculaire, Hôpital de Bicêtre, Paris, France.

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December 1999
1 Read
2.447 Impact Factor

Effect of plasminogen activators on human recombinant apolipoprotein(a) having the plasminogen activation cleavage site.

Biochim Biophys Acta 1999 Sep;1434(1):124-34

Scripps Research Institute, TSRI-VB3, La Jolla, CA, USA.

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September 1999
1 Read

Evidence that modifications of Lp(a) in vivo inhibit plasmin formation on fibrin--a study with individual plasmas presenting natural variations of Lp(a).

Thromb Haemost 1999 Jul;82(1):121-7

Inserm U.143, Hôpital de Bicêtre, Paris, France.

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July 1999
1 Read
4.984 Impact Factor

Advances in autoantibodies in SLE.

Lupus 1998 ;7(8):507-14

PUC School of Medicine, Porto Alegre, Brazil.

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http://dx.doi.org/10.1191/096120398678920613DOI Listing
March 1999
1 Read
2.197 Impact Factor

A novel kringle-4 number-based recombinant apo[a] standard for human apo[a] phenotyping.

J Lipid Res 1999 Feb;40(2):354-9

INSERM U.143, Hôpital de Bicêtre, Paris, France.

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February 1999
1 Read
4.421 Impact Factor

Fibrino(geno)lytic properties of purified hementerin, a metalloproteinase from the leech Haementeria depressa.

Thromb Haemost 1998 Jul;80(1):155-60

Laboratório de Fisiopatologia, Instituto Butantan, São Paulo, Brasil.

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July 1998
1 Read
4.984 Impact Factor

Structural basis for the pathophysiology of lipoprotein(a) in the athero-thrombotic process.

Authors:
E Anglés-Cano

Braz J Med Biol Res 1997 Nov;30(11):1271-80

Institut National de la Santé et de la Recherche Médicale (INSERM), U. 143, Centre Hospitalier Universitaire de Bicêtre, Université de Paris-Sud, Paris, France.

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November 1997
1 Read
1.034 Impact Factor

Lipoprotein(a) isoforms display differences in affinity for plasminogen-like binding to human mononuclear cells.

Arterioscler Thromb Vasc Biol 1997 Oct;17(10):2036-43

INSERM U.143, Hôpital de Bicêtre, Paris, France.

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October 1997
1 Read
6.000 Impact Factor

[Hemostasis].

Rev Invest Clin 1997 May;49 Suppl 1:34-41

INSERM U. 143, Hôpital de Bicêtre, Paris, France.

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May 1997
1 Read

[Thrombophilia].

Rev Invest Clin 1997 May;49 Suppl 1:49-55

Instituto Nacional de Cardiología, Ignacio Chávez, México.

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May 1997
1 Read

Primary pulmonary hypertension, tissue plasminogen activator antibodies, and HLA-DQ7.

Am J Respir Crit Care Med 1997 Jan;155(1):274-8

Children's Pulmonary Hypertension Center, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA.

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http://dx.doi.org/10.1164/ajrccm.155.1.9001324DOI Listing
January 1997
2 Reads
12.996 Impact Factor

The antifibrinolytic effect of lipoprotein(a) in heterozygous subjects is modulated by the relative concentration of each of the apolipoprotein(a) isoforms and their affinity for fibrin.

Eur J Clin Invest 1996 May;26(5):411-7

Institut National de la Santé et de la Recherche Médicale, INSERM U143, Centre Hospitalier Universitaire de Bicêtre, Paris, France.

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May 1996
1 Read
2.734 Impact Factor

Development and clinical application of a new ELISA assay to determine plasmin-alpha2-antiplasmin complexes in plasma.

Br J Haematol 1996 Mar;92(4):979-85

Laboratory of Vascular Biology and Thrombosis Research, School of Medicine, University of Navarra, Pamplona, Spain.

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March 1996
1 Read
4.711 Impact Factor

Acquired protein S deficiency with primary antiphospholipid syndrome and recurrent thrombotic events: report of a case.

Rev Rhum Engl Ed 1995 Dec;62(11):810-11

Department of Immunology and Rheumatology, Hospital General de Occidente de la SS, Zapopan, Jal, Mexico.

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December 1995
1 Read

Multiple binding with identical linkage: a mechanism that explains the effect of lipoprotein(a) on fibrinolysis.

Biochemistry 1995 Oct;34(41):13353-8

Institut National de la Santé et de la Recherche Médicale, INSERM U.143, Centre Hospitalier Universitaire de Bicêtre, Paris, France.

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October 1995
1 Read
3.015 Impact Factor

[Risk predictors and secondary prevention in angina pectoris and after myocardial infarct].

Internist (Berl) 1995 Sep;36(9):883-90

Abteilung für Kardiologie, Universität Wien.

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September 1995
1 Read
0.271 Impact Factor

Antibodies to fibrin bound tissue type plasminogen activator in systemic sclerosis.

J Rheumatol 1995 Sep;22(9):1688-93

Department of Medicine, University of Calgary, Canada.

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September 1995
2 Reads
3.187 Impact Factor

Serum antibodies to distinct epitopes of the tissue-type plasminogen activator (t-PA) in patients with systemic lupus erythematosus.

Am J Hematol 1995 Jun;49(2):109-14

Laboratorios Clinicos de Puebla, Mexico.

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June 1995
2 Reads
3.798 Impact Factor

Limited proteolysis of human alpha-thrombin by urokinase yields a non-clotting enzyme.

Thromb Haemost 1995 Feb;73(2):275-80

Laboratoire de Recherche sur l'Hémostase et la Thrombose, Faculté Xavier Bichat, Paris, France.

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February 1995
1 Read
4.984 Impact Factor

Endothelial cell markers (vWF, t-PA and PAI-1) in the elderly.

Thromb Haemost 1994 Jul;72(1):164-5

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July 1994
1 Read
4.984 Impact Factor

Study of tissue-type plasminogen activator binding sites on fibrin using distinct fragments of fibrinogen.

Eur J Biochem 1994 Feb;219(3):961-7

Unité 143 of the Institut National de la Santé et de la Recherche Médicale, Hôpital de Bicêtre, France.

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February 1994
1 Read

Effects of lipoprotein(a) on the binding of plasminogen to fibrin and its activation by fibrin-bound tissue-type plasminogen activator.

Chem Phys Lipids 1994 Jan;67-68:369-80

Institut National de la Santé et de la Recherche Médicale (INSERM) U.143, Hôpital de Bicêtre, France.

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January 1994
4 Reads
2.422 Impact Factor

Overview on fibrinolysis: plasminogen activation pathways on fibrin and cell surfaces.

Authors:
E Anglés-Cano

Chem Phys Lipids 1994 Jan;67-68:353-62

Institut National de la Santé et de la Recherche Médicale (INSERM) U. 143, Hôpital de Bicêtre, France.

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January 1994
1 Read
2.422 Impact Factor

The mutation in fibrinogen Bicêtre II (gamma Asn308-->Lys) does not affect the binding of t-PA and plasminogen to fibrin.

Blood Coagul Fibrinolysis 1993 Oct;4(5):679-87

Unité 143, Institut National de la Santé et de la Recherche Médicale, Centre Hospitalo-Universitaire de Bicêtre, France.

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October 1993
1 Read
1.380 Impact Factor

Molecular assembly of plasminogen and tissue-type plasminogen activator on an evolving fibrin surface.

Eur J Biochem 1993 Sep;216(2):549-56

Institut National de la Santé et de la Recherche Médicale, Centre Hospitalo-Universitaire of Bicêtre, France.

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September 1993
1 Read

Mechanism of the enhanced intrinsic activity of single-chain urokinase-type plasminogen activator during ongoing fibrinolysis.

J Biol Chem 1993 Sep;268(25):18554-9

Institut National de la Santé et de la Recherche Médicale U.143, Hôpital de Bicêtre, France.

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September 1993
22 Reads
4.573 Impact Factor

Does apolipoprotein(a) heterogeneity influence lipoprotein(a) effects on fibrinolysis?

Blood 1993 Jul;82(2):392-7

Institut National de la Santé et de la Recherche Médicale, INSERM U. 143, Hôpital de Bicêtre, Paris, France.

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July 1993
1 Read
10.452 Impact Factor

Sodium dodecyl sulfate-induced dissociation of complexes between human tissue plasminogen activator and its specific inhibitor.

J Biol Chem 1993 Jun;268(16):12150-5

Institut National de la Santé et de la Recherche Médicale, Unité 143, Centre Hospitalo-Universitaire de Bicêtre, Paris, France.

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June 1993
1 Read
4.573 Impact Factor

Familial association of high levels of histidine-rich glycoprotein and plasminogen activator inhibitor-1 with venous thromboembolism.

J Lab Clin Med 1993 May;121(5):646-53

Institut National de la Santé et de la Recherche Médicale, U.143, Hôpital de Bicêtre, Paris, France.

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May 1993
1 Read

Plasminogen binding by alpha 2-antiplasmin and histidine-rich glycoprotein does not inhibit plasminogen activation at the surface of fibrin.

Biochim Biophys Acta 1992 Dec;1156(1):34-42

INSERM U. 143, Hôpital de Bicêtre, France.

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December 1992
1 Read

Apolipoprotein(a) and plasminogen interactions with fibrin: a study with recombinant apolipoprotein(a) and isolated plasminogen fragments.

Biochemistry 1992 Jul;31(27):6333-9

Institut National de la Santé et de la Recherche Médicale (INSERM), U.143, Hôpital de Bicêtre, Paris, France.

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July 1992
1 Read
3.015 Impact Factor

Hedgehog lipoprotein(a) is a modulator of activation of plasminogen at the fibrin surface. An in vitro study.

Arterioscler Thromb 1992 Feb;12(2):146-54

Institut National de la Santé et de la Recherche Médicale (INSERM) U. 143, Hôpital de Bicêtre, France.

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February 1992
1 Read

The formation of complexes between human plasminogen activator inhibitor-1 (PAI-1) and sodium dodecyl sulfate: possible implication in the functional properties of PAI-1.

Biochim Biophys Acta 1991 Sep;1079(3):321-9

Institut National de la Santé et de la Recherche Médicale, Hôpital de Bicêtre, France.

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September 1991
1 Read

Characterization of the binding of plasminogen to fibrin surfaces: the role of carboxy-terminal lysines.

Biochemistry 1991 Jul;30(30):7630-8

Institut National de la Santé et de la Recherche Médicale, Hôpital de Bicêtre, France.

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July 1991
1 Read
3.015 Impact Factor

Lipoprotein(a) impairs generation of plasmin by fibrin-bound tissue-type plasminogen activator. In vitro studies in a plasma milieu.

Arterioscler Thromb 1991 May-Jun;11(3):629-38

Unité 143, Hôpital de Bicêtre, France.

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June 1991
3 Reads

The pH dependence of the binding of pro-urokinase to fibrin/celite.

Thromb Haemost 1990 Dec;64(4):556-8

Vascular Research Laboratory, New England Deaconess Hospital, Harvard Medical School, Boston, MA 02215.

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December 1990
1 Read
4.984 Impact Factor

The mechanism of activation of plasminogen at the fibrin surface by tissue-type plasminogen activator in a plasma milieu in vitro. Role of alpha 2-antiplasmin.

Biochem J 1990 Oct;271(1):51-7

Institut National de la Santé et de la Recherche Médicale, Hôpital de Bicêtre, France.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1149513PMC
October 1990
1 Read
4.396 Impact Factor

Factors affecting the stability of tPA and PAI-1 during storage and handling of human plasma for in vitro studies: implications in the determination of tPA and PAI-1 activities.

Blood Coagul Fibrinolysis 1990 Oct;1(4-5):393-9

INSERM U.143, Institut de Pathologie Cellulaire, Hôpital de Bicêtre, Paris, France.

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October 1990
1 Read
1.380 Impact Factor

Slow and fast rat skeletal muscles differ in their plasminogen activator activities.

Eur J Cell Biol 1990 Jun;52(1):157-62

Laboratoire de Cytologie et Cultures Cellulaires, UFR de Sciences, Université Paris XII, Créteil/France.

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June 1990
1 Read
3.825 Impact Factor

[Quantification of a specific inhibitor (PAI-1) of tissue-type plasminogen activator (t-PA) in the plasma].

Ann Biol Clin (Paris) 1989 ;47(5):269-74

INSERM U 143, Institut de Pathologie Cellulaire, Hôpital de Bicêtre.

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August 1989
1 Read
0.415 Impact Factor

Endothelial damage and hypofibrinolysis in systemic lupus erythematosus.

Authors:
E Angles-Cano

Thromb Haemost 1989 Apr;61(2):322

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April 1989
1 Read
4.984 Impact Factor

Functional identification of t-PA in crude and purified systems.

Thromb Res Suppl 1988 ;8:123-30

INSERM U. 143, Hôpital de Bicêtre, France.

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January 1989
1 Read

Kinetic analysis of the interaction between plasminogen activator inhibitor-1 and tissue-type plasminogen activator.

Biochem J 1988 Nov;256(1):237-44

I.N.S.E.R.M. U. 143, Institut de Pathologie Cellulaire, Hôpital de Bicêtre, France.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1135393PMC
November 1988
1 Read
4.396 Impact Factor

A method for the determination of the affinity constant of antibodies to tissue plasminogen activator.

Thromb Res 1988 Jun;50(5):687-94

INSERM U. 143, Institut de Pathologie Cellulaire, Hôpital de Bicêtre, France.

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June 1988
1 Read
2.447 Impact Factor

Release pattern of the vascular plasminogen activator and its inhibitor in human postvenous occlusion plasma as assessed by a spectrophotometric solid-phase fibrin-tPA activity assay.

Thromb Haemost 1987 Oct;58(3):843-9

INSERM U. 143, Institut de Pathologie Cellulaire, Hôpital de Bicêtre, Paris, France.

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October 1987
1 Read
4.984 Impact Factor

Polyunsaturated fatty acids increase fibrinolytic activity of human isolated glomeruli.

Kidney Int 1986 Nov;30(5):701-5

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November 1986
1 Read
8.563 Impact Factor

Identification and cellular localization of plasminogen activators from human glomeruli.

Thromb Haemost 1985 Oct;54(3):688-92

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October 1985
1 Read
4.984 Impact Factor

Release of VIII R:Ag and VIII R:WF during thrombin and collagen induced aggregation.

Thromb Res 1979 ;15(3-4):415-25

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December 1979
1 Read
2.447 Impact Factor

[Purification of the vascular plasminogen activator].

C R Seances Acad Sci D 1979 Sep;289(5):485-7

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September 1979
1 Read

Thrombophlebitis in systemic lupus erythematosus.

JAMA 1979 Jun;241(26):2785-6

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June 1979
1 Read
35.289 Impact Factor

Top co-authors

Eduardo Anglés-Cano
Eduardo Anglés-Cano

Inserm/Université Paris Descartes

10
Laurent Plawinski
Laurent Plawinski

Université de Caen

8
Jean-Baptiste Michel
Jean-Baptiste Michel

Bichat-Claude Bernard Hospital

7
Benoit Ho-Tin-Noe
Benoit Ho-Tin-Noe

Université Paris Diderot

6
Patrick Rossignol
Patrick Rossignol

University Hospital Nancy

5
Denis Vivien
Denis Vivien

Normandie Univ

5
Gabriella Pepe
Gabriella Pepe

University of Bari

4
Olivier Meilhac
Olivier Meilhac

Autonoma University

4
Marie-Paule Jacob
Marie-Paule Jacob

Université Paris 7

4