Dr. Eduardo Anglés-Cano, MD, ScD,PhD - Inserm/Université Paris Descartes - Director of Research

Dr. Eduardo Anglés-Cano

MD, ScD,PhD

Inserm/Université Paris Descartes

Director of Research

Paris | France

Dr. Eduardo Anglés-Cano, MD, ScD,PhD - Inserm/Université Paris Descartes - Director of Research

Dr. Eduardo Anglés-Cano

MD, ScD,PhD
Introduction

We are pioneer in the study of fibrinolytic microvesicles (MVs) as functional messengers of plasmin generation. MVs derived from cells that express plasminogen activators may generate, disseminate and transfer plasmin proteolytic activity (Blood, 2007). For instance, besides endothelial cells and leucocytes, neurons are able to release microvesicles bearing plasmin and tPA activity (Biochem J 2010). We have found that endothelial cell- and leucocyte- derived microvesicles bear the machinery necessary for plasmin formation including plasminogen activators and its receptors: tPA for endothelial MVs and the uPA/uPAR system for leukocyte MVs (Haematologica 2013). Presently, we are prospecting on synthetic tools to identify phosphatidylserine on cell membranes.
Furthermore, we have discovered a new mechanism for plasmin formation that bypass the requirement for co-assembly of plasminogen and uPA on the same surface (Blood 2010). These heterotypic cell-to-cell (platelets/ monocytes; platelets/MPs), cell-to-matrix (leukocytes/fibrin), or MPs-to-matrix (MPs/fibrin) proteolytic cross-talk represents an alternative pathway for localized plasmin formation that may be relevant not only for fibrinolysis, but also for processes such as cell migration and MP dissemination. Finally, our data provide additional evidence for a novel role of MPs and platelets, as vectors that generate and propagate plasmin fibrinolytic and/or proteolytic activity, and could thereby constitute a pharmacologic tool.
At the Inserm reaserch unit UMR_S 1140 (Faculty of pharmaceutical and biological sciences, Paris) we have studied the fibrinolytic and microvesiculation properties of human bone marrow mesenchymal stem cells (submitted). Our translational research is mainly related to the role of NET transformation of PMN on the fibrinolytic response to ischaemic diseases.

Primary Affiliation: Inserm/Université Paris Descartes - Paris , France


View Dr. Eduardo Anglés-Cano’s Resume / CV
Metrics

40

Publications

204

Profile Views

164

Reads

400

PubMed Central Citations

Top co-authors
Eduardo Anglés-Cano
Eduardo Anglés-Cano

Inserm/Université Paris Descartes

9
Laurent Plawinski
Laurent Plawinski

Université de Caen

8
Benoit Ho-Tin-Noe
Benoit Ho-Tin-Noe

Université Paris Diderot

6
Jean-Baptiste Michel
Jean-Baptiste Michel

Bichat-Claude Bernard Hospital

6
Patrick Rossignol
Patrick Rossignol

University Hospital Nancy

5
Denis Vivien
Denis Vivien

Normandie Univ

5
Gabriella Pepe
Gabriella Pepe

University of Bari

4
Olivier Meilhac
Olivier Meilhac

Autonoma University

4
Marie-Paule Jacob
Marie-Paule Jacob

Université Paris 7

4

Publications

40Publications

164Reads

400PubMed Central Citations

Evidence of Netosis in Septic Shock-Induced Disseminated Intravascular Coagulation.

Shock 2017 03;47(3):313-317

*Medical Intensive Care Unit, NHC - Strasbourg University Hospital, Strasbourg, France †EA 7293 FMTS, University of Strasbourg, Strasbourg, France ‡Laboratory of Medical Biostatistics and Informatics, University of Strasbourg, Strasbourg, France §Group Method in Clinical Research, Public Health Unit, Strasbourg University Hospital, Strasbourg, France ||Hematology and heamostasis laboratory, Hautepierre - Strasbourg University Hospital, Strasbourg, France ¶EA 3430 FMTS, University of Strasbourg, Strasbourg, France #EA 7290, University of Strasbourg, Strasbourg, France **CNRS UMR 7213, University of Strasbourg, Illkirch, France ††Paris Descartes University, Sorbonne, Paris, France ‡‡INSERM UMR S1140, Paris, France.

View Article
March 2017
4 Reads
10 PubMed Central Citations(source)
3.04 Impact Factor

Exome Sequencing and Clot Lysis Experiments Demonstrate the R458C Mutation of the Alpha Chain of Fibrinogen to be Associated with Impaired Fibrinolysis in a Family with Thrombophilia.

J Atheroscler Thromb 2016 17;23(4):431-40. Epub 2015 Nov 17.

Stroke pharmacogenomics and genetics laboratory, Fundació Docencia i Recerca MutuaTerrassa, Hospital Mutua de Terrassa.

View Article
January 2017
5 Reads
1 PubMed Central Citation(source)
2.73 Impact Factor

Evidence for several independent genetic variants affecting lipoprotein (a) cholesterol levels.

Hum Mol Genet 2015 Apr 9;24(8):2390-400. Epub 2015 Jan 9.

Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, MD 21201, USA,

View Article
April 2015
2 Reads
15 PubMed Central Citations(source)
6.39 Impact Factor

Membrane microvesicles: a circulating source for fibrinolysis, new antithrombotic messengers.

Haematologica 2013 Jul;98(7):e75-6

View Article
July 2013
1 PubMed Central Citation(source)
5.87 Impact Factor

Lipoprotein(a) and homocysteine potentiate the risk of coronary artery disease in male subjects.

Circ J 2012 18;76(8):1953-7. Epub 2012 May 18.

Instituto Nacional de Cardiología Ignacio Chávez, Grupo Genética Intervencionista, Departamentos de Biología Molecular, Hemodinámica, Endocrinología, Unidad Coronaria, Juan Badiano 1, México.

View Article
December 2012
1 Read
2 PubMed Central Citations(source)
3.94 Impact Factor

Synergistic effect of thrombin and CD40 ligand on endothelial matrix metalloproteinase-10 expression and microparticle generation in vitro and in vivo.

Arterioscler Thromb Vasc Biol 2012 Jun 5;32(6):1477-87. Epub 2012 Apr 5.

Laboratory of Atherothrombosis, Division of Cardiovascular Sciences, CIMA, Av. Pio XII, 55, 31008 Pamplona, Navarra, Spain.

View Article
June 2012
7 Reads
14 PubMed Central Citations(source)
6.00 Impact Factor

Plasmin on adherent cells: from microvesiculation to apoptosis.

Biochem J 2010 Dec;432(2):365-73

Inserm U919, GiP Cyceron, Bd Henri Becquerel, 14074 Caen, France.

View Article
December 2010
5 Reads
10 PubMed Central Citations(source)
4.40 Impact Factor

Sizing nanomatter in biological fluids by fluorescence single particle tracking.

Nano Lett 2010 Nov 5;10(11):4435-42. Epub 2010 Oct 5.

Laboratory of General Biochemistry and Physical Pharmacy, Ghent University, Harelbekestraat 72, 9000 Gent, Belgium.

View Article
November 2010
12 PubMed Central Citations(source)
13.59 Impact Factor

Plasmin induces apoptosis of aortic valvular myofibroblasts.

J Pathol 2010 May;221(1):37-48

Inserm, UMR698, Hemostasis, Bio-Engineering and Cardiovascular Remodelling, Paris 7 Denis Diderot University, Hôpital Bichat-Claude Bernard, 46 Rue Henri Huchard, 75877 Paris Cedex 18, France.

View Article
May 2010
1 Read
4 PubMed Central Citations(source)
7.43 Impact Factor

Fibrinolytic cross-talk: a new mechanism for plasmin formation.

Blood 2010 Mar 7;115(10):2048-56. Epub 2009 Dec 7.

Inserm, U919, Caen, France.

View Article
March 2010
2 Reads
20 PubMed Central Citations(source)
10.45 Impact Factor

Role of plasminogen activation in neuronal organization and survival.

Mol Cell Neurosci 2009 Dec 14;42(4):288-95. Epub 2009 Aug 14.

Inserm U698, Université Paris Diderot-Paris 7, 75018 Paris, France.

View Article
December 2009
2 Reads
12 PubMed Central Citations(source)
3.84 Impact Factor

[Cerebral ischemia (2), How to neutralize the neurotoxic effects of tPA].

Med Sci (Paris) 2009 Oct;25(10):855-7

Inserm U919, Sérine protéases et physiopathologie de l'unité neurovasculaire, UMR-CNRS 6232 CINAPS, Cyceron, F-14074 Caen, France.

View Article
October 2009
21 Reads
1 PubMed Central Citation(source)
0.52 Impact Factor

[Cellular microparticles, potential useful biomarkers in the identification of cerebrovascular accidents].

Med Sci (Paris) 2009 Oct;25(10):843-6

Inserm U919, Sérine protéases et physiopathologie de l'unité neurovasculaire, UMR-CNRS 6232 CINAPS, Cyceron, Caen, F-14074 France.

View Article
October 2009
1 PubMed Central Citation(source)
0.52 Impact Factor

Cell-derived microparticles: a new challenge in neuroscience.

J Neurochem 2009 Jul 13;110(2):457-68. Epub 2009 May 13.

INSERM U, Université de Caen, France.

View Article
July 2009
16 PubMed Central Citations(source)
4.28 Impact Factor

[Cell-derived microparticles unveil their fibrinolytic and proteolytic function].

Med Sci (Paris) 2009 Jan;25(1):37-44

Inserm U919, Sérine Protéases et Physiopathologie de l'Unité neurovasculaire, CiNaps, UMR CNRS 6232, GIP Cyceron, boulevard Henri Becquerel, 14074 Caen Cedex, France.

View Article
January 2009
2 PubMed Central Citations(source)
0.52 Impact Factor

Relationship between apo(a) length polymorphism and lipoprotein(a) concentration in healthy Ivorian subjects with single or double apo(a) isoforms.

Clin Biochem 2008 Sep 12;41(13):1039-43. Epub 2008 Jun 12.

Laboratory of Biochemistry, UFR Pharmaceutical and Biological Sciences, Abidjan, Côte d'Ivoire.

View Article
September 2008
3 Reads
2.23 Impact Factor

Activation of plasminogen into plasmin at the surface of endothelial microparticles: a mechanism that modulates angiogenic properties of endothelial progenitor cells in vitro.

Blood 2007 Oct 2;110(7):2432-9. Epub 2007 Jul 2.

Unité Mixte de Recherche S 608 (UMR-S 608), Institut National de la Santé et de la Recherche Médicale (INSERM), Université de la Méditerranée, Unité de Formation et de Recherche (UFR) de Pharmacie, Marseille, France.

View Article
October 2007
43 PubMed Central Citations(source)
10.45 Impact Factor

Mouse model of in situ thromboembolic stroke and reperfusion.

Stroke 2007 Oct 16;38(10):2771-8. Epub 2007 Aug 16.

INSERM-Avenir tPA in the working brain, University of Caen, Centre CYCERON, Bd Becquerel, BP 5229, 14074 Caen Cedex, France.

View Article
October 2007
1 Read
48 PubMed Central Citations(source)
5.72 Impact Factor

A case of afibrinogenemia associated with A-alpha chain gene compound heterozygosity (HUMFIBRA c.[4110delA]+[3200+1G>T]).

Blood Coagul Fibrinolysis 2007 Jan;18(1):73-5

Inserm U698, Université Paris7-Denis Diderot, Paris, France.

View Article
January 2007
2 Reads
1 PubMed Central Citation(source)
1.38 Impact Factor

Plasminogen activator inhibitor-1 impairs plasminogen activation-mediated vascular smooth muscle cell apoptosis.

Thromb Haemost 2006 Nov;96(5):665-70

Center for Molecular and Vascular Biology, K.U.Leuven, Leuven, Belgium.

View Article
November 2006
10 PubMed Central Citations(source)
4.98 Impact Factor

Lipoprotein(a) in the cerebrospinal fluid of neurological patients with blood-cerebrospinal fluid barrier dysfunction.

Clin Chem 2006 Nov 21;52(11):2043-8. Epub 2006 Sep 21.

Department of Biochemistry and Molecular Biology, University of Bari, Italy.

View Article
November 2006
2 PubMed Central Citations(source)
7.91 Impact Factor

Interaction of fibrin(ogen) with apolipoprotein(a): further characterization and identification of a novel lysine-dependent apolipoprotein(a)-binding site within the gamma chain 287-411 region.

Biochemistry 2006 Sep;45(35):10624-32

Center for Vascular and Inflammatory Diseases and Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA.

View Article
September 2006
1 Read
2 PubMed Central Citations(source)
3.02 Impact Factor

Functional characterization of fibrinogen Bicêtre II: a gamma 308 Asn-->Lys mutation located near the fibrin D:D interaction sites.

Blood Coagul Fibrinolysis 2006 Apr;17(3):193-201

Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA.

View Article
April 2006
3 PubMed Central Citations(source)
1.38 Impact Factor

Mechanism for the homocysteine-enhanced antifibrinolytic potential of lipoprotein(a) in human plasma.

Thromb Haemost 2005 Jul;94(1):75-81

INSERM U698, CHU Bichat-Claude Bernard, 46 rue Henri Huchard, F-75877-Cdx, Paris 18, France.

View Article
July 2005
1 PubMed Central Citation(source)
4.98 Impact Factor

Functional hierarchy of plasminogen kringles 1 and 4 in fibrinolysis and plasmin-induced cell detachment and apoptosis.

FEBS J 2005 Jul;272(13):3387-400

INSERM U698, Centre Hospitalier Universitaire Bichat-Claude Bernard, Paris, France.

View Article
July 2005
6 Reads
8 PubMed Central Citations(source)
4.00 Impact Factor

The plasminogen-MMP system is more activated in the scar than in viable myocardium 3 months post-MI in the rat.

J Mol Cell Cardiol 2005 Jan 9;38(1):193-204. Epub 2004 Dec 9.

Inserm U460, Cardiovascular Remodeling, CHU Xavier Bichat-Claude Bernard, 46, rue Henri Huchard, 75877 Paris cedex 18, France.

View Article
January 2005
3 Reads
8 PubMed Central Citations(source)
4.66 Impact Factor

Neutrophils stimulated by apolipoprotein(a) generate fragments that are stronger inhibitors of plasmin formation than apo(a).

Thromb Haemost 2004 Nov;92(5):1066-75

Department of Biochemistry & Molecular Biology & IBBE-CNR, University of Bari, Italy.

View Article
November 2004
1 Read
2 PubMed Central Citations(source)
4.98 Impact Factor

Protease nexin-1 inhibits plasminogen activation-induced apoptosis of adherent cells.

J Biol Chem 2004 Mar 29;279(11):10346-56. Epub 2003 Dec 29.

INSERM U460, Centre Hospitalier Universitaire Bichat-Claude Bernard, Paris 18, France.

View Article
March 2004
2 Reads
26 PubMed Central Citations(source)
4.57 Impact Factor

Identification and characterization of novel lysine-independent apolipoprotein(a)-binding sites in fibrin(ogen) alphaC-domains.

J Biol Chem 2003 Sep 9;278(39):37154-9. Epub 2003 Jul 9.

Jerome H. Holland Laboratory for the Biomedical Sciences, American Red Cross, Rockville, Maryland 20855, USA.

View Article
September 2003
6 PubMed Central Citations(source)
4.57 Impact Factor

Pericellular plasmin induces smooth muscle cell anoikis.

FASEB J 2003 Jul 8;17(10):1301-3. Epub 2003 May 8.

INSERM U460, CHU Bichat-Claude Bernard, 75018 Paris, France.

View Article
July 2003
2 Reads
25 PubMed Central Citations(source)
5.04 Impact Factor

Involvement of the mural thrombus as a site of protease release and activation in human aortic aneurysms.

Am J Pathol 2002 Nov;161(5):1701-10

Institut National de la Santé et de la Recherche Médicale U460, Cardiovascular Remodeling, Hôpital Xavier Bichat, Paris, France.

View Article
November 2002
2 Reads
48 PubMed Central Citations(source)
4.59 Impact Factor

Bivalency of plasminogen monoclonal antibodies is required for plasminogen bridging to fibrin and enhanced plasmin formation.

Biochim Biophys Acta 2002 Jul;1598(1-2):165-76

Plasminogen Activation in Cardiovascular Remodelling, Institut National de la Santé et de la Recherche Médicale, INSERM U460, UFR de Médecine Xavier Bichat, 16 rue Henri Huchard-BP 416, Paris, France.

View Article
July 2002
1 Read
1 PubMed Central Citation(source)

[Physiopathology of aortic aneurysm].

Rev Prat 2002 May;52(10):1061-5

INSERM Unité 460 (Remodelage cardiovasculaire) Faculté de médecine Xavier Bichat B.P. 416 75870 Paris.

View Article
May 2002
15 Reads
1 PubMed Central Citation(source)

Apolipoprotein(a): structure-function relationship at the lysine-binding site and plasminogen activator cleavage site.

Biol Chem 2002 Jan;383(1):93-9

Institut National de la Santé et de la Recherche, Médicale, Faculté de Médecine Xavier-Bichat, Paris, France.

View Article
January 2002
3 PubMed Central Citations(source)
3.27 Impact Factor

Experimental Study of Fibrin/Fibrin-Specific Molecular Interactions Using a Sphere/Plane Adhesion Model.

J Colloid Interface Sci 2001 Sep;241(1):52-62

Institut de Mécanique des Fluides de Toulouse, UMR CNRS 5502, Allée du Professeur C. Soula, Toulouse, 31400, France

View Article
September 2001
1 Read
5 PubMed Central Citations(source)
3.37 Impact Factor
Top co-authors
Eduardo Anglés-Cano
Eduardo Anglés-Cano

Inserm/Université Paris Descartes

9
Laurent Plawinski
Laurent Plawinski

Université de Caen

8
Benoit Ho-Tin-Noe
Benoit Ho-Tin-Noe

Université Paris Diderot

6
Jean-Baptiste Michel
Jean-Baptiste Michel

Bichat-Claude Bernard Hospital

6
Patrick Rossignol
Patrick Rossignol

University Hospital Nancy

5
Denis Vivien
Denis Vivien

Normandie Univ

5
Gabriella Pepe
Gabriella Pepe

University of Bari

4
Olivier Meilhac
Olivier Meilhac

Autonoma University

4
Marie-Paule Jacob
Marie-Paule Jacob

Université Paris 7

4