Publications by authors named "Edoardo Alesse"

55Publications

Circulating MicroRNAs as Prognostic and Therapeutic Biomarkers in Breast Cancer Molecular Subtypes.

J Pers Med 2020 Aug 22;10(3). Epub 2020 Aug 22.

Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, Via Vetoio, Coppito 2, 67100 L'Aquila, Italy.

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http://dx.doi.org/10.3390/jpm10030098DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7563822PMC
August 2020

Leptin in Tumor Microenvironment.

Adv Exp Med Biol 2020 ;1259:89-112

Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy.

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http://dx.doi.org/10.1007/978-3-030-43093-1_6DOI Listing
July 2020

Long-term abuse of a high-carbohydrate diet is as harmful as a high-fat diet for development and progression of liver injury in a mouse model of NAFLD/NASH.

Nutrition 2020 Jul - Aug;75-76:110782. Epub 2020 Mar 5.

Department of Anatomical, Histological, Forensic Medicine and Orthopedic Sciences, Sapienza University of Rome, Italy.

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http://dx.doi.org/10.1016/j.nut.2020.110782DOI Listing
March 2020

Life, death, and autophagy in cancer: NF-κB turns up everywhere.

Cell Death Dis 2020 03 30;11(3):210. Epub 2020 Mar 30.

Department of Biotechnological and Applied Clinical Sciences (DISCAB), University of L'Aquila, 67100, L'Aquila, Italy.

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http://dx.doi.org/10.1038/s41419-020-2399-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7105474PMC
March 2020

Applications of Next Generation Sequencing to the Analysis of Familial Breast/Ovarian Cancer.

High Throughput 2020 Jan 10;9(1). Epub 2020 Jan 10.

Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, Via Vetoio, Coppito 2, 67100 L'Aquila, Italy.

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http://dx.doi.org/10.3390/ht9010001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7151204PMC
January 2020

NF-κB and mitochondria cross paths in cancer: mitochondrial metabolism and beyond.

Semin Cell Dev Biol 2020 02 12;98:118-128. Epub 2019 Jun 12.

Department of Biotechnological and Applied Clinical Sciences (DISCAB), University of L'Aquila, 67100, L'Aquila, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.semcdb.2019.05.021DOI Listing
February 2020

Next-generation sequencing: recent applications to the analysis of colorectal cancer.

J Transl Med 2017 Dec 8;15(1):246. Epub 2017 Dec 8.

Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, 67100, Italy.

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http://dx.doi.org/10.1186/s12967-017-1353-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5723063PMC
December 2017

Cancer secretome and inflammation: The bright and the dark sides of NF-κB.

Semin Cell Dev Biol 2018 06 2;78:51-61. Epub 2017 Aug 2.

Department of Biotechnological and Applied Clinical Sciences (DISCAB), University of L'Aquila, 67100 L'Aquila, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.semcdb.2017.08.004DOI Listing
June 2018

Perivascular Cells in Diffuse Cutaneous Systemic Sclerosis Overexpress Activated ADAM12 and Are Involved in Myofibroblast Transdifferentiation and Development of Fibrosis.

J Rheumatol 2016 07 1;43(7):1340-9. Epub 2016 Jun 1.

From the Department of Applied Clinical Sciences and Biotechnology, Rheumatology Unit, School of Medicine, and the Department of Applied Clinical Sciences and Biotechnology, General Pathology Unit, University of L'Aquila, L'Aquila; Dipartimento Biomedico di Medicina Interna e Specialistica, Sezione di Reumatologia, Università degli Studi di Palermo, Palermo, Italy.P. Cipriani, MD, PhD, Department of Applied Clinical Sciences and Biotechnology, Rheumatology Unit, School of Medicine, University of L'Aquila; P. Di Benedetto, PhD, Department of Applied Clinical Sciences and Biotechnology, Rheumatology Unit, School of Medicine, University of L'Aquila; P. Ruscitti, MD, Department of Applied Clinical Sciences and Biotechnology, Rheumatology Unit, School of Medicine, University of L'Aquila; V. Liakouli, MD, PhD, Department of Applied Clinical Sciences and Biotechnology, Rheumatology Unit, School of Medicine, University of L'Aquila; O. Berardicurti, MD, Department of Applied Clinical Sciences and Biotechnology, Rheumatology Unit, School of Medicine, University of L'Aquila; F. Carubbi, MD, Department of Applied Clinical Sciences and Biotechnology, Rheumatology Unit, School of Medicine, University of L'Aquila; F. Ciccia, MD, PhD, Dipartimento Biomedico di Medicina Interna e Specialistica, Sezione di Reumatologia, Università degli Studi di Palermo; G. Guggino, MD, Dipartimento Biomedico di Medicina Interna e Specialistica, Sezione di Reumatologia, Università degli Studi di Palermo; F. Zazzeroni, PhD, Department of Applied Clinical Sciences and Biotechnology, General Pathology Unit, University of L'Aquila; E. Alesse, MD, PhD, Department of Applied Clinical Sciences and Biotechnology, General Pathology Unit, University of L'Aquila; G. Triolo, MD, PhD, Dipartimento Biomedico di Medicina Interna e Specialistica, Sezione di Reumatologia, Università degli Studi di Palermo; R. Giacomelli, MD, PhD, Department of Applied Clinical Sciences and Biotechnology, Rheumatology Unit, School

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http://dx.doi.org/10.3899/jrheum.150996DOI Listing
July 2016

Macitentan inhibits the transforming growth factor-β profibrotic action, blocking the signaling mediated by the ETR/TβRI complex in systemic sclerosis dermal fibroblasts.

Arthritis Res Ther 2015 Sep 10;17:247. Epub 2015 Sep 10.

Department of Applied Clinical Sciences and Biotechnology, Rheumatology Unit, School of Medicine, University of L'Aquila, Delta 6 Building, Via dell'Ospedale, 67100, L'Aquila, Italy.

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http://dx.doi.org/10.1186/s13075-015-0754-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4566861PMC
September 2015

Targeting the NF-κB pathway in prostate cancer: a promising therapeutic approach?

Curr Drug Targets 2016 ;17(3):311-20

Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, Via Vetoio, Coppito II, 67100 L'Aquila, Italy.

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http://dx.doi.org/10.2174/1389450116666150907100715DOI Listing
October 2016

Therapeutic Use of MicroRNAs in Cancer.

Anticancer Agents Med Chem 2016 ;16(1):7-19

Dept. of Biotechnological and Applied Clinical Sciences, University of L'Aquila, Via Vetoio, Coppito II, L'Aquila, Italy.

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http://dx.doi.org/10.2174/1871520615666150824153358DOI Listing
August 2016

The Endothelial-mesenchymal Transition in Systemic Sclerosis Is Induced by Endothelin-1 and Transforming Growth Factor-β and May Be Blocked by Macitentan, a Dual Endothelin-1 Receptor Antagonist.

J Rheumatol 2015 Oct 15;42(10):1808-16. Epub 2015 Aug 15.

From the Department of Applied Clinical Sciences and Biotechnology, Rheumatology Unit, School of Medicine, and the Department of Applied Clinical Sciences and Biotechnology, General Phatology Unit, University of L'Aquila, L'Aquila; Medical and Scientific Direction, Actelion Pharmaceuticals Italy, Imola, Italy; Drug Discovery Department, Actelion Pharmaceuticals Ltd., Allschwil, Switzerland.P. Cipriani, MD, PhD; P. Di Benedetto, PhD; P. Ruscitti, MD, Department of Applied Clinical Sciences and Biotechnology, Rheumatology Unit, School of Medicine, University of L'Aquila; D. Capece, PhD; F. Zazzeroni, PhD, Department of Applied Clinical Sciences and Biotechnology, General Phatology Unit, University of L'Aquila; V. Liakouli, MD, PhD; I. Pantano, MD; O. Berardicurti, MD; F. Carubbi, MD, Department of Applied Clinical Sciences and Biotechnology, Rheumatology Unit, School of Medicine, University of L'Aquila; G. Pecetti, MD; S. Turricchia, MD, Medical and Scientific Direction, Actelion Pharmaceuticals Italy; E. Alesse, MD, PhD, Department of Applied Clinical Sciences and Biotechnology, General Pathology Unit, University of L'Aquila; M. Iglarz, PhD, Drug Discovery Department, Actelion Pharmaceuticals Ltd.; R. Giacomelli, MD, PhD, Department of Applied Clinical Sciences and Biotechnology, Rheumatology Unit, School of Medicine, University of L'Aquila.

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http://dx.doi.org/10.3899/jrheum.150088DOI Listing
October 2015

The role of IL-1β in the bone loss during rheumatic diseases.

Mediators Inflamm 2015 12;2015:782382. Epub 2015 Apr 12.

Department of Biotechnological and Applied Clinical Sciences, Rheumatology Unit, University of L'Aquila, Delta 6 Building, 67100 L'Aquila, Italy.

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http://dx.doi.org/10.1155/2015/782382DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4410538PMC
February 2016

The prevalent KRAS exon 2 c.35 G>A mutation in metastatic colorectal cancer patients: A biomarker of worse prognosis and potential benefit of bevacizumab-containing intensive regimens?

Crit Rev Oncol Hematol 2015 Mar 16;93(3):190-202. Epub 2014 Oct 16.

Medical Oncology, S. Salvatore Hospital, University of L'Aquila, L'Aquila, Italy; Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.critrevonc.2014.10.004DOI Listing
March 2015

Impaired Cav-1 expression in SSc mesenchymal cells upregulates VEGF signaling: a link between vascular involvement and fibrosis.

Fibrogenesis Tissue Repair 2014 15;7:13. Epub 2014 Sep 15.

Department of Applied Clinical Sciences and Biotechnology, Rheumatology Unit, School of Medicine, University of L'Aquila, Delta 6 Building, Via dell'Ospedale, 67100 L'Aquila, Italy.

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http://dx.doi.org/10.1186/1755-1536-7-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4166421PMC
September 2014

Molecular pathogenesis of bone metastases in breast cancer: Proven and emerging therapeutic targets.

World J Clin Oncol 2014 Aug;5(3):335-47

Nadia Rucci, Patrizia Sanità, Simona Delle Monache, Edoardo Alesse, Adriano Angelucci, Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, Coppito 67100, L'Aquila, Italy.

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http://www.wjgnet.com/2218-4333/full/v5/i3/335.htm
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http://dx.doi.org/10.5306/wjco.v5.i3.335DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4127605PMC
August 2014

KCTD11 tumor suppressor gene expression is reduced in prostate adenocarcinoma.

Biomed Res Int 2014 19;2014:380398. Epub 2014 Jun 19.

Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, Via Vetoio, Coppito 2, 67100 L'Aquila, Italy.

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http://dx.doi.org/10.1155/2014/380398DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4090506PMC
March 2015

MicroRNAs in the DNA Damage/Repair Network and Cancer.

Int J Genomics 2014 30;2014:820248. Epub 2014 Jan 30.

Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, Via Vetoio, Coppito 2, 67100 L'Aquila, Italy.

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http://dx.doi.org/10.1155/2014/820248DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3926391PMC
June 2014

Reverse-phase protein microarray highlights HER2 signaling activation in immunohistochemistry/FISH/HER2-negative breast cancers.

Expert Rev Proteomics 2013 Jun;10(3):223-6

Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, Via Vetoio, Coppito 2, 67100, L'Aquila, Italy.

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http://dx.doi.org/10.1586/epr.13.18DOI Listing
June 2013

The inflammatory microenvironment in hepatocellular carcinoma: a pivotal role for tumor-associated macrophages.

Biomed Res Int 2013 30;2013:187204. Epub 2012 Dec 30.

Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, 67100 L'Aquila, Italy.

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http://dx.doi.org/10.1155/2013/187204DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3591180PMC
September 2013

Serum biomarkers identification by mass spectrometry in high-mortality tumors.

Int J Proteomics 2013 15;2013:125858. Epub 2013 Jan 15.

Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, Via Vetoio Coppito 2, 67100 L'Aquila, Italy.

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http://dx.doi.org/10.1155/2013/125858DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3562576PMC
February 2013

Stem cells in autoimmune diseases: Implications for pathogenesis and future trends in therapy.

Autoimmun Rev 2013 May 24;12(7):709-16. Epub 2012 Nov 24.

Rheumatology Unit, Clinical Science and Biotechnology Department, University of L'Aquila, Italy.

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http://dx.doi.org/10.1016/j.autrev.2012.10.004DOI Listing
May 2013

Targeting costimulatory molecules to improve antitumor immunity.

J Biomed Biotechnol 2012 12;2012:926321. Epub 2012 Feb 12.

Department of Experimental Medicine, University of L'Aquila, L'Aquila, Italy.

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http://www.hindawi.com/journals/bmri/2012/926321/
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http://dx.doi.org/10.1155/2012/926321DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3303883PMC
September 2012

Age-associated changes in mouse oocytes during postovulatory in vitro culture: possible role for meiotic kinases and survival factor BCL2.

Biol Reprod 2006 Feb 26;74(2):395-402. Epub 2005 Oct 26.

Department of Biomedical Sciences and Technologies, University of L'Aquila, 67100 L'Aquila, Italy.

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http://dx.doi.org/10.1095/biolreprod.105.046169DOI Listing
February 2006

Chromosome 17p deletion in human medulloblastoma: a missing checkpoint in the Hedgehog pathway.

Cell Cycle 2004 Oct 3;3(10):1263-6. Epub 2004 Oct 3.

Department of Experimental Medicine and Pathology, University La Sapienza, Rome, Italy.

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http://www.tandfonline.com/doi/abs/10.4161/cc.3.10.1200
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http://dx.doi.org/10.4161/cc.3.10.1200DOI Listing
October 2004

Specific role for p300/CREB-binding protein-associated factor activity in E2F1 stabilization in response to DNA damage.

J Biol Chem 2004 Jul 3;279(29):30830-5. Epub 2004 May 3.

Department of Experimental Medicine and Pathology, University of Rome La Sapienza, 00161 Rome, Italy.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M402403200
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http://dx.doi.org/10.1074/jbc.M402403200DOI Listing
July 2004

Differential regulation of E2F1 apoptotic target genes in response to DNA damage.

Nat Cell Biol 2003 Jun;5(6):552-8

Laboratory of Gene Expression, Fondazione Andrea Cesalpino, University of Rome La Sapienza, Viale del Policlinico 155, 00161 Rome, Italy.

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http://www.nature.com/articles/ncb998
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http://dx.doi.org/10.1038/ncb998DOI Listing
June 2003

Angiotensin II inhibits endothelial cell motility through an AT1-dependent oxidant-sensitive decrement of nitric oxide availability.

Arterioscler Thromb Vasc Biol 2003 Jul 22;23(7):1218-23. Epub 2003 May 22.

Department of Internal Medicine and Public Health, University of L'Aquila, Via Vetoio, Blocco 11, 67100, Coppito, L'Aquila, Italy.

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https://www.ahajournals.org/doi/10.1161/01.ATV.0000078521.51
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http://dx.doi.org/10.1161/01.ATV.0000078521.51319.65DOI Listing
July 2003