Edmund A Mroz

Edmund A Mroz

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Edmund A Mroz

Edmund A Mroz

Publications by authors named "Edmund A Mroz"

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17Publications

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Single-Cell Transcriptomic Analysis of Primary and Metastatic Tumor Ecosystems in Head and Neck Cancer.

Cell 2017 Dec 30;171(7):1611-1624.e24. Epub 2017 Nov 30.

Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00928674173127
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http://dx.doi.org/10.1016/j.cell.2017.10.044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5878932PMC
December 2017

The challenges of tumor genetic diversity.

Cancer 2017 05 8;123(6):917-927. Epub 2016 Nov 8.

Department of Otolaryngology-Head and Neck Surgery, The James Cancer Hospital and Solove Research Institute, The Ohio State University, Columbus, Ohio.

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http://dx.doi.org/10.1002/cncr.30430DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5370554PMC
May 2017

Intra-tumor heterogeneity in head and neck cancer and its clinical implications.

World J Otorhinolaryngol Head Neck Surg 2016 Jun 22;2(2):60-67. Epub 2016 Jul 22.

Department of Otolaryngology-Head and Neck Surgery, The James Cancer Hospital and Solove Research Institute, The Ohio State University, Columbus, OH, USA.

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http://dx.doi.org/10.1016/j.wjorl.2016.05.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5477669PMC
June 2016

Comparison of the Genomic Landscape Between Primary Breast Cancer in African American Versus White Women and the Association of Racial Differences With Tumor Recurrence.

J Clin Oncol 2015 Nov 14;33(31):3621-7. Epub 2015 Sep 14.

Tanya Keenan, Beverly Moy, Kenneth Ross, Andrzej Niemierko, Steven Isakoff, Leif W. Ellisen, and Aditya Bardia, Massachusetts General Hospital, Harvard Medical School, Boston, MA; and Edmund A. Mroz and James W. Rocco, Ohio State University/Wexner Medical Center and James Cancer Center, Ohio State University, Columbus, OH.

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http://dx.doi.org/10.1200/JCO.2015.62.2126DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4979243PMC
November 2015

Intra-tumor genetic heterogeneity and mortality in head and neck cancer: analysis of data from the Cancer Genome Atlas.

PLoS Med 2015 Feb 10;12(2):e1001786. Epub 2015 Feb 10.

Center for Cancer Research and Division of Surgical Oncology, Massachusetts General Hospital, Boston, Massachusetts, United States of America; Department of Otology and Laryngology, Harvard Medical School and Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, United States of America; Department of Otolaryngology-Head and Neck Surgery, Ohio State University, Columbus, Ohio, United States of America.

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http://dx.doi.org/10.1371/journal.pmed.1001786DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4323109PMC
February 2015

High intratumor genetic heterogeneity is related to worse outcome in patients with head and neck squamous cell carcinoma.

Cancer 2013 Aug 20;119(16):3034-42. Epub 2013 May 20.

Center for Cancer Research and Department of Surgery, Massachusetts General Hospital, Boston, MA 02114, USA.

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http://dx.doi.org/10.1002/cncr.28150DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3735618PMC
August 2013

Impact of human papillomavirus on oropharyngeal cancer biology and response to therapy: implications for treatment.

Otolaryngol Clin North Am 2013 Aug 27;46(4):521-43. Epub 2013 Jun 27.

Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, 243 Charles Street, Boston, MA 02114, USA.

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http://dx.doi.org/10.1016/j.otc.2013.04.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3740406PMC
August 2013

MATH, a novel measure of intratumor genetic heterogeneity, is high in poor-outcome classes of head and neck squamous cell carcinoma.

Oral Oncol 2013 Mar 15;49(3):211-5. Epub 2012 Oct 15.

Center for Cancer Research and Department of Surgery, Massachusetts General Hospital, Boston, MA 02114, USA.

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http://dx.doi.org/10.1016/j.oraloncology.2012.09.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3570658PMC
March 2013

Bcl2 and human papilloma virus 16 as predictors of outcome following concurrent chemoradiation for advanced oropharyngeal cancer.

Clin Cancer Res 2010 Apr 16;16(7):2138-46. Epub 2010 Mar 16.

Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Massachusetts General Hospital, Boston, MA 02114, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-09-3185DOI Listing
April 2010

Functional p53 status as a biomarker for chemotherapy response in oral-cavity cancer.

J Clin Oncol 2010 Feb 4;28(5):715-7. Epub 2010 Jan 4.

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http://dx.doi.org/10.1200/JCO.2009.26.3475DOI Listing
February 2010

Bcl-2 blocks cisplatin-induced apoptosis and predicts poor outcome following chemoradiation treatment in advanced oropharyngeal squamous cell carcinoma.

Clin Cancer Res 2009 Mar 24;15(5):1645-54. Epub 2009 Feb 24.

Massachusetts General Hospital (MGH) Cancer Center, Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-08-2581DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2745309PMC
March 2009

HPV-16 infection predicts treatment outcome in oropharyngeal squamous cell carcinoma.

Otolaryngol Head Neck Surg 2009 Feb;140(2):228-34

Department of Otology and Laryngology, Massachusetts Eye and Ear Infirmary, Boston, MA, USA.

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http://dx.doi.org/10.1016/j.otohns.2008.11.025DOI Listing
February 2009

COOH-terminal binding protein regulates expression of the p16INK4A tumor suppressor and senescence in primary human cells.

Cancer Res 2008 Aug;68(15):6049-53

Department of Surgery, Division of Surgical Oncology, Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, Massachusetts 02114, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-08-1279DOI Listing
August 2008

RNA interference: natural, experimental, and clinical roles in cancer biology.

Head Neck 2006 Dec;28(12):1132-41

Division of Surgical Oncology, Department of Surgery, Massachusetts General Hospital, 55 Fruit St., Boston, MA 02114, USA.

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http://dx.doi.org/10.1002/hed.20439DOI Listing
December 2006