Publications by authors named "Edith Hummler"

77Publications

Plasma Potassium Determines NCC Abundance in Adult Kidney-Specific ENaC Knockout.

J Am Soc Nephrol 2018 03 25;29(3):977-990. Epub 2018 Jan 25.

Department of Pharmacology and Toxicology, University of Lausanne, Lausanne, Switzerland;

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http://dx.doi.org/10.1681/ASN.2017030345DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5827588PMC
March 2018

Severe hyperkalemia is rescued by low-potassium diet in renal βENaC-deficient mice.

Pflugers Arch 2017 10 31;469(10):1387-1399. Epub 2017 May 31.

Department of Pharmacology and Toxicology, University of Lausanne, Rue du Bugnon 27, 1011, Lausanne, Switzerland.

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http://dx.doi.org/10.1007/s00424-017-1990-2DOI Listing
October 2017

Current knowledge on biomarkers for contact sensitization and allergic contact dermatitis.

Contact Dermatitis 2017 Jul 12;77(1):1-16. Epub 2017 May 12.

Department of Dermatology and Allergy, National Allergy Research Centre, Herlev and Gentofte Hospital, University of Copenhagen, 2900, Hellerup, Denmark.

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http://dx.doi.org/10.1111/cod.12789DOI Listing
July 2017

Altered Prostasin (CAP1/Prss8) Expression Favors Inflammation and Tissue Remodeling in DSS-induced Colitis.

Inflamm Bowel Dis 2016 12;22(12):2824-2839

*Département de Pharmacologie and de Toxicologie, University of Lausanne, Lausanne, Switzerland; Sumedha Malsure is now with the Elanco Animal Health, Basel, Switzerland; and †Institut Universitaire de Pathologie, University Hospital of Lausanne (CHUV), Lausanne, Switzerland.

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http://dx.doi.org/10.1097/MIB.0000000000000940DOI Listing
December 2016

The function and regulation of acid-sensing ion channels (ASICs) and the epithelial Na(+) channel (ENaC): IUPHAR Review 19.

Br J Pharmacol 2016 09 10;173(18):2671-701. Epub 2016 Aug 10.

Department of Pharmacology and Toxicology, University of Lausanne, Lausanne, Switzerland.

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http://dx.doi.org/10.1111/bph.13533DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4995293PMC
September 2016

Adult nephron-specific MR-deficient mice develop a severe renal PHA-1 phenotype.

Pflugers Arch 2016 05 14;468(5):895-908. Epub 2016 Jan 14.

Department of Pharmacology and Toxicology, University of Lausanne, Rue du Bugnon 27, CH-1011, Lausanne, Switzerland.

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http://dx.doi.org/10.1007/s00424-015-1785-2DOI Listing
May 2016

Severe Salt-Losing Syndrome and Hyperkalemia Induced by Adult Nephron-Specific Knockout of the Epithelial Sodium Channel α-Subunit.

J Am Soc Nephrol 2016 08 23;27(8):2309-18. Epub 2015 Dec 23.

Department of Pharmacology and Toxicology, University of Lausanne, Lausanne, Switzerland; Swiss National Center of Competence in Research "Kidney.CH", Zurich, Switzerland;

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http://dx.doi.org/10.1681/ASN.2015020154DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4978035PMC
August 2016

Reducing αENaC expression in the kidney connecting tubule induces pseudohypoaldosteronism type 1 symptoms during K+ loading.

Am J Physiol Renal Physiol 2016 Feb 18;310(4):F300-10. Epub 2015 Nov 18.

Department of Biomedicine, Aarhus University, Aarhus, Denmark;

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http://dx.doi.org/10.1152/ajprenal.00258.2015DOI Listing
February 2016

Tgfbi/Bigh3 silencing activates ERK in mouse retina.

Exp Eye Res 2015 Nov 24;140:159-170. Epub 2015 Sep 24.

Institut de Recherche en Ophtalmologie, Sion, Switzerland; Ecole polytechnique fédérale de Lausanne, Faculté des Sciences de la vie, Lausanne, Switzerland.

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https://linkinghub.elsevier.com/retrieve/pii/S00144835153002
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http://dx.doi.org/10.1016/j.exer.2015.09.004DOI Listing
November 2015

ENaC activity in collecting ducts modulates NCC in cirrhotic mice.

Pflugers Arch 2015 Dec 10;467(12):2529-39. Epub 2015 Jun 10.

Department of Nephrology, Hypertension and Clinical Pharmacology, Inselspital, Bern University Hospital, Bern, Switzerland.

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http://dx.doi.org/10.1007/s00424-015-1711-7DOI Listing
December 2015

Regulation of blood pressure and renal function by NCC and ENaC: lessons from genetically engineered mice.

Curr Opin Pharmacol 2015 Apr 20;21:60-72. Epub 2015 Jan 20.

Department of Pharmacology and Toxicology, University of Lausanne, Lausanne, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.coph.2014.12.012DOI Listing
April 2015

Generation of TALEN-mediated GRdim knock-in rats by homologous recombination.

PLoS One 2014 11;9(2):e88146. Epub 2014 Feb 11.

Department of Pharmacology and Toxicology, University of Lausanne, Lausanne, Switzerland.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0088146PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3921256PMC
October 2014

Hypoxia-induced inhibition of epithelial Na(+) channels in the lung. Role of Nedd4-2 and the ubiquitin-proteasome pathway.

Am J Respir Cell Mol Biol 2014 Mar;50(3):526-37

1 Université Paris 13, Sorbonne Paris Cité, Laboratoire Réponses Cellulaires et Fonctionnelles à l'Hypoxie (EA 2363), Bobigny, France.

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http://dx.doi.org/10.1165/rcmb.2012-0518OCDOI Listing
March 2014

Nitric oxide reduces Cl⁻ absorption in the mouse cortical collecting duct through an ENaC-dependent mechanism.

Am J Physiol Renal Physiol 2013 Jun 20;304(11):F1390-7. Epub 2013 Mar 20.

Department of Medicine, Renal Division, Emory University School of Medicine, Atlanta, GA, USA.

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http://dx.doi.org/10.1152/ajprenal.00292.2012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3680692PMC
June 2013

The epithelial sodium channel mediates the directionality of galvanotaxis in human keratinocytes.

J Cell Sci 2013 May 27;126(Pt 9):1942-51. Epub 2013 Feb 27.

Department of Dermatology, University of California, Davis, CA 95616, USA.

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http://dx.doi.org/10.1242/jcs.113225DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3666251PMC
May 2013

Reduced prostasin (CAP1/PRSS8) activity eliminates HAI-1 and HAI-2 deficiency-associated developmental defects by preventing matriptase activation.

PLoS Genet 2012 30;8(8):e1002937. Epub 2012 Aug 30.

Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1002937DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3431340PMC
January 2013

Sodium channels and mammalian sensory mechanotransduction.

Mol Pain 2012 Mar 26;8:21. Epub 2012 Mar 26.

Molecular Nociception Group, Wolfson Institute for Biomedical Research, University College London, London WC1E 6BT, UK.

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http://dx.doi.org/10.1186/1744-8069-8-21DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3378430PMC
March 2012

Coat color dilution in mice because of inactivation of the melanoma antigen MART-1.

Pigment Cell Melanoma Res 2012 Jan 7;25(1):37-46. Epub 2011 Oct 7.

Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.

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http://dx.doi.org/10.1111/j.1755-148X.2011.00910.xDOI Listing
January 2012

alphaENaC-mediated lithium absorption promotes nephrogenic diabetes insipidus.

J Am Soc Nephrol 2011 Feb 4;22(2):253-61. Epub 2010 Nov 4.

Water and Salt Research Center, Department of Anatomy, Aarhus University, Wilhelm Meyers Allé 3, 8000 Aarhus C, Denmark.

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http://www.jasn.org/cgi/doi/10.1681/ASN.2010070734
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http://dx.doi.org/10.1681/ASN.2010070734DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3029898PMC
February 2011

The cells and peripheral representation of sodium taste in mice.

Nature 2010 Mar 27;464(7286):297-301. Epub 2010 Jan 27.

Howard Hughes Medical Institute and Department of Neurobiology, University of California at San Diego, La Jolla, California 92093-0649, USA

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http://dx.doi.org/10.1038/nature08783DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2849629PMC
March 2010

Importance of ENaC-mediated sodium transport in alveolar fluid clearance using genetically-engineered mice.

Cell Physiol Biochem 2010 22;25(1):63-70. Epub 2009 Dec 22.

Département de Pharmacologie & Toxicologie, Université de Lausanne, Switzerland.

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http://dx.doi.org/10.1159/000272051DOI Listing
February 2010

Thiazolidinedione-induced fluid retention is independent of collecting duct alphaENaC activity.

J Am Soc Nephrol 2009 Apr 21;20(4):721-9. Epub 2009 Jan 21.

Nephrology and Hypertension, Department of Medicine, University of California, San Diego, and Veterans Affairs San Diego Healthcare System, 3350 La Jolla Village Drive (9151), San Diego, California 92161, USA.

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http://dx.doi.org/10.1681/ASN.2008040415DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2663822PMC
April 2009

Transgenic mice and their impact on kidney research.

Pflugers Arch 2009 May 16;458(1):211-22. Epub 2008 Dec 16.

CNRS-FRE, Université de Nice Sophia-Antipolis, France.

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http://link.springer.com/10.1007/s00424-008-0624-0
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http://dx.doi.org/10.1007/s00424-008-0624-0DOI Listing
May 2009

Conditional gene targeting of the ENaC subunit genes Scnn1b and Scnn1g.

Am J Physiol Renal Physiol 2009 Feb 26;296(2):F249-56. Epub 2008 Nov 26.

Département de Pharmacologie et de Toxicologie, Univ. of Lausanne, Rue du Bugnon 27, CH-1005 Lausanne, Switzerland.

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http://dx.doi.org/10.1152/ajprenal.00612.2007DOI Listing
February 2009

Postnatal requirement of the epithelial sodium channel for maintenance of epidermal barrier function.

J Biol Chem 2008 Feb 26;283(5):2622-30. Epub 2007 Nov 26.

Département de Pharmacologie & de Toxicologie, Université de Lausanne, Rue du Bugnon 27, Lausanne, Switzerland.

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http://dx.doi.org/10.1074/jbc.M708829200DOI Listing
February 2008

Low expression of the beta-ENaC subunit impairs lung fluid clearance in the mouse.

Am J Physiol Lung Cell Mol Physiol 2008 Mar 16;294(3):L409-16. Epub 2007 Nov 16.

INSERM U773, CRB3, Université Denis Diderot-Paris 7, 16 rue Henri Huchard, 75018 Paris, France.

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http://dx.doi.org/10.1152/ajplung.00307.2007DOI Listing
March 2008

Tissue-specific transgenic and knockout mice.

Methods Mol Biol 2006 ;337:185-205

Transgenic Animal Facility, Faculty of Biology and Medicine, University of Lausanne, Switzerland.

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http://dx.doi.org/10.1385/1-59745-095-2:185DOI Listing
December 2006

GLUT8 is dispensable for embryonic development but influences hippocampal neurogenesis and heart function.

Mol Cell Biol 2006 Jun;26(11):4268-76

Institute of Physiology, University of Lausanne, Center for Integrative Genomics, Génopode Building, CH-1015 Lausanne, Switzerland.

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http://dx.doi.org/10.1128/MCB.00081-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1489108PMC
June 2006

Activation of epithelial sodium channels by mouse channel activating proteases (mCAP) expressed in Xenopus oocytes requires catalytic activity of mCAP3 and mCAP2 but not mCAP1.

J Am Soc Nephrol 2006 Apr 8;17(4):968-76. Epub 2006 Mar 8.

Institut de Pharmacologie et de Toxicologie, Université de Lausanne, Rue du Bugnon 27, Lausanne, CH-1005 Switzerland.

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http://www.jasn.org/cgi/doi/10.1681/ASN.2005060637
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http://dx.doi.org/10.1681/ASN.2005060637DOI Listing
April 2006

Lessons from mouse mutants of epithelial sodium channel and its regulatory proteins.

J Am Soc Nephrol 2005 Nov 28;16(11):3160-6. Epub 2005 Sep 28.

Département de Pharmacologie et de Toxicologie, Université de Lausanne, Lausanne, Switzerland.

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http://dx.doi.org/10.1681/ASN.2005040450DOI Listing
November 2005

The epidermal barrier function is dependent on the serine protease CAP1/Prss8.

J Cell Biol 2005 Aug;170(3):487-96

Département de Pharmacologie et de Toxicologie, Université de Lausanne, CH-1005 Lausanne, Switzerland.

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http://dx.doi.org/10.1083/jcb.200501038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2171460PMC
August 2005

In vitro and in vivo regulation of transepithelial lung alveolar sodium transport by serine proteases.

Am J Physiol Lung Cell Mol Physiol 2005 Jun 28;288(6):L1099-109. Epub 2005 Jan 28.

Department of Physiology, INSERM U426, Faculté de Medécine Xavier Bichat, Université Paris 7, Paris, France.

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http://dx.doi.org/10.1152/ajplung.00332.2004DOI Listing
June 2005

Vasopressin-stimulated CFTR Cl- currents are increased in the renal collecting duct cells of a mouse model of Liddle's syndrome.

J Physiol 2005 Jan 28;562(Pt 1):271-84. Epub 2004 Oct 28.

INSERM U478, Faculté de Médecine Xavier Bichat, 16 rue Henri Huchard, BP 416, 75870 Paris Cedex 18, France.

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http://dx.doi.org/10.1113/jphysiol.2004.077933DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1665473PMC
January 2005

Defective respiratory amiloride-sensitive sodium transport predisposes to pulmonary oedema and delays its resolution in mice.

J Physiol 2004 Nov 12;560(Pt 3):857-65. Epub 2004 Aug 12.

Department of Internal Medicine, Centre Hospitalier Universitaire Vaudois, CH-1011 Lausanne, Switzerland.

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http://dx.doi.org/10.1113/jphysiol.2004.066704DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1665279PMC
November 2004

A nonconventional look at ionic fluxes in the skin: lessons from genetically modified mice.

News Physiol Sci 2004 Apr;19:75-9

Départment de Pharmacologie et de Toxicologie, Université de Lausanne, CH-1005 Lausanne, Switzerland.

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http://dx.doi.org/10.1152/nips.01503.2003DOI Listing
April 2004

Chronic hyperaldosteronism in a transgenic mouse model fails to induce cardiac remodeling and fibrosis under a normal-salt diet.

Am J Physiol Renal Physiol 2004 Jun 3;286(6):F1178-84. Epub 2004 Feb 3.

Dept. of Pharmacology and Toxicology, Rue du Bugnon 27, CH-1005 Lausanne, Switzerland.

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http://www.physiology.org/doi/10.1152/ajprenal.00386.2003
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http://dx.doi.org/10.1152/ajprenal.00386.2003DOI Listing
June 2004

Dysfunction of the epithelial sodium channel expressed in the kidney of a mouse model for Liddle syndrome.

J Am Soc Nephrol 2003 Sep;14(9):2219-28

Institut de Pharmacologie et de Toxicologie de l'Université, Lausanne, Switzerland.

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http://dx.doi.org/10.1097/01.asn.0000080204.65527.e6DOI Listing
September 2003

Mineralocorticoid regulation of epithelial Na+ channels is maintained in a mouse model of Liddle's syndrome.

Am J Physiol Renal Physiol 2003 Aug 8;285(2):F310-8. Epub 2003 Apr 8.

Department of Physiology and Biophysics, Weill Medical College of Cornell Univ., 1300 York Ave., New York, NY 10021, USA.

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http://dx.doi.org/10.1152/ajprenal.00016.2003DOI Listing
August 2003

Epithelial sodium channel, salt intake, and hypertension.

Authors:
Edith Hummler

Curr Hypertens Rep 2003 Feb;5(1):11-8

Institut de Pharmacologie et de Toxicologie, Université de Lausanne, Rue du Bugnon 27, CH-1005 Lausanne, Switzerland.

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http://dx.doi.org/10.1007/s11906-003-0005-1DOI Listing
February 2003

Selected contribution: limiting Na(+) transport rate in airway epithelia from alpha-ENaC transgenic mice: a model for pulmonary edema.

J Appl Physiol (1985) 2002 Nov;93(5):1881-7

Institut de Pharmacologie et de Toxicologie, Université de Lausanne, CH-1005 Lausanne, Switzerland.

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http://dx.doi.org/10.1152/japplphysiol.00413.2002DOI Listing
November 2002

Expression of Cre recombinase in pigment cells.

Pigment Cell Res 2002 Aug;15(4):305-9

ISREC (Swiss Institute for Experimental Cancer Research), Chemin des Boveresses 155, CH-1066 Epalinges, Switzerland.

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http://dx.doi.org/10.1034/j.1600-0749.2002.02039.xDOI Listing
August 2002

Blood pressure, cardiac, and renal responses to salt and deoxycorticosterone acetate in mice: role of Renin genes.

J Am Soc Nephrol 2002 Jun;13(6):1509-16

Division of Hypertension and Vascular Medicine, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.

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http://dx.doi.org/10.1097/01.asn.0000017902.77985.84DOI Listing
June 2002

Absence of fibroblast growth factor 2 does not prevent tumor formation originating from the RPE.

Oncogene 2002 Mar;21(12):1841-7

ISREC (Swiss Institute for Experimental Cancer Research), Chemin des Boveresses 155, CH-1066 Epalinges, Switzerland.

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http://dx.doi.org/10.1038/sj.onc.1205030DOI Listing
March 2002

A conditional allele at the mouse channel activating protease 1 (Prss8) gene locus.

Genesis 2002 Feb;32(2):173-6

Institut de Pharmacologie et de Toxicologie de l'Université de Lausanne, Lausanne, Switzerland.

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http://dx.doi.org/10.1002/gene.10040DOI Listing
February 2002

Conditional gene targeting of the Scnn1a (alphaENaC) gene locus.

Genesis 2002 Feb;32(2):169-72

Institut de Pharmacologie et de Toxicologie, Université de Lausanne, Lausanne, Switzerland.

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http://dx.doi.org/10.1002/gene.10041DOI Listing
February 2002

Epithelial sodium channel and the control of sodium balance: interaction between genetic and environmental factors.

Annu Rev Physiol 2002 ;64:877-97

Institute of Pharmacology and Toxicology, University of Lausanne, Rue du Bugnon 27, Lausanne, CH-1005 Switzerland.

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http://www.annualreviews.org/doi/10.1146/annurev.physiol.64.
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http://dx.doi.org/10.1146/annurev.physiol.64.082101.143243DOI Listing
May 2002