Professor Edgar Pick, M.D.,Ph.D. - Sackler School of Medicine - Professor Emeritus

Professor Edgar Pick

M.D.,Ph.D.

Sackler School of Medicine

Professor Emeritus

Tel Aviv, Tel Aviv | Israel

Main Specialties: Allergy & Immunology, Biology, Biotechnology, Hematology, Infectious Disease, Medical Microbiology

Additional Specialties: Biochemistry, Molecular Biology

ORCID logohttps://orcid.org/0000-0003-4625-3233


Top Author

Professor Edgar Pick, M.D.,Ph.D. - Sackler School of Medicine - Professor Emeritus

Professor Edgar Pick

M.D.,Ph.D.

Introduction

1965-1967 Scripps Clinic and Research Foundation Postdoctoral fellow
Experimental
Pathology
1967-1970 University of London
Institute of Dermatology Post M.D. doctoral fellow and Ph.D. student
1970-1975 Tel Aviv University
Sackler School of Medicine Senior Lecturer Immunology
1975-1979 Tel Aviv University
Sackler School of Medicine Associate Professor Immunology
1979-1980 National Institutes of Health, Bethesda, MD Visiting Scientist
(sabbatical) Immunology
1979-2008 Tel Aviv University
Sackler School of Medicine Professor Immunology
2008 – present Tel Aviv University
Sackler School of Medicine Professor Emeritus

Primary Affiliation: Sackler School of Medicine - Tel Aviv, Tel Aviv , Israel

Specialties:

Additional Specialties:

Research Interests:


View Professor Edgar Pick’s Resume / CV

Education

Oct 1970
Universiy of London
Ph.D.
Feb 1965
Hebrew University - Hadassah Medical School
M.D.

Experience

Sep 1979
Visiting Scientist, NIH, Bethesda
Oct 1970
Ph.D., University of London

Publications

33Publications

279Reads

44Profile Views

p67 -derived self-assembled peptides prevent Nox2 NADPH oxidase activation by an auto-inhibitory mechanism.

J Leukoc Biol 2020 Jul 8. Epub 2020 Jul 8.

The Julius Friedrich Cohnheim Laboratory of Phagocyte Research, Department of Clinical Microbiology and Immunology, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.

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http://dx.doi.org/10.1002/JLB.4A0620-292RDOI Listing
July 2020
4.289 Impact Factor

p67 binds to a newly identified site in Nox2 following the disengagement of an intramolecular bond-Canaan sighted?

J Leukoc Biol 2020 03 22;107(3):509-528. Epub 2020 Jan 22.

The Julius Friedrich Cohnheim Laboratory of Phagocyte Research, Department of Clinical Microbiology and Immunology, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.

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http://dx.doi.org/10.1002/JLB.4A1219-607RDOI Listing
March 2020
4.289 Impact Factor

Cell-Free NADPH Oxidase Activation Assays: A Triumph of Reductionism.

Authors:
Edgar Pick

Methods Mol Biol 2020 ;2087:325-411

Department of Clinical Microbiology and Immunology, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.

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http://dx.doi.org/10.1007/978-1-0716-0154-9_23DOI Listing
January 2020

Using Synthetic Peptides for Exploring Protein-Protein Interactions in the Assembly of the NADPH Oxidase Complex.

Authors:
Edgar Pick

Methods Mol Biol 2019 ;1982:377-415

Department of Clinical Microbiology and Immunology, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.

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http://dx.doi.org/10.1007/978-1-4939-9424-3_23DOI Listing
January 2020
14 Reads

Binding of p67 to Nox2 is stabilized by disulfide bonds between cysteines in the Cys-Gly-Cys triad in Nox2 and in p67.

J Leukoc Biol 2018 11 16;104(5):1023-1039. Epub 2018 Jul 16.

The Julius Friedrich Cohnheim Laboratory of Phagocyte Research, Department of Clinical Microbiology and Immunology, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.

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http://dx.doi.org/10.1002/JLB.4A0418-173RDOI Listing
November 2018
6 Reads
4.289 Impact Factor

Turning off NADPH oxidase-2 by impeding p67 activation in infected mouse macrophages reduced viral entry and inflammation.

Biochim Biophys Acta Gen Subj 2018 06 8;1862(6):1263-1275. Epub 2018 Mar 8.

Paris Saclay University, U892 INRA, Jouy en Josas, France; Paris Saclay University, Gustave Roussy Institute, UMR 8200 CNRS, Villejuif, France. Electronic address:

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http://dx.doi.org/10.1016/j.bbagen.2018.03.004DOI Listing
June 2018
3 Reads
4.381 Impact Factor

Absolute and Relative Activity Values in Assessing the Effect of NADPH Oxidase Inhibitors.

Authors:
Edgar Pick

Antioxid Redox Signal 2015 Nov;23(15):1250-1

Julius Friedrich Cohnheim Laboratory of Phagocyte Research, Department of Clinical Microbiology and Immunology, Sackler School of Medicine, Tel Aviv University , Tel Aviv, Israel .

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http://dx.doi.org/10.1089/ars.2015.6470DOI Listing
November 2015
3 Reads
7.407 Impact Factor

A Cys-Gly-Cys triad in the dehydrogenase region of Nox2 plays a key role in the interaction with p67phox.

J Leukoc Biol 2015 Nov 9;98(5):859-74. Epub 2015 Jul 9.

*The Julius Friedrich Cohnheim Laboratory of Phagocyte Research, Department of Clinical Microbiology and Immunology, Sackler School of Medicine, Tel Aviv University, Israel; and Department of Biology and Physics, College of Science and Mathematics, Kennesaw State University, Kennesaw, Georgia, USA

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http://dx.doi.org/10.1189/jlb.4A0315-107RDOI Listing
November 2015
15 Reads
4.289 Impact Factor

Role of the Rho GTPase Rac in the activation of the phagocyte NADPH oxidase: outsourcing a key task.

Authors:
Edgar Pick

Small GTPases 2014 5;5:e27952. Epub 2014 Mar 5.

Julius Friedrich Cohnheim Laboratory of Phagocyte Research; Department of Clinical Microbiology and Immunology; Sackler School of Medicine; Tel Aviv University; Tel Aviv, Israel.

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http://dx.doi.org/10.4161/sgtp.27952DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4114928PMC
February 2015
9 Reads

The dehydrogenase region of the NADPH oxidase component Nox2 acts as a protein disulfide isomerase (PDI) resembling PDIA3 with a role in the binding of the activator protein p67 (phox.).

Front Chem 2015 4;3. Epub 2015 Feb 4.

The Julius Friedrich Cohnheim Laboratory of Phagocyte Research, Department of Clinical Microbiology and Immunology, Sackler School of Medicine, Tel Aviv University Tel Aviv, Israel.

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http://dx.doi.org/10.3389/fchem.2015.00003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4316792PMC
February 2015
7 Reads

Cell-free NADPH oxidase activation assays: "in vitro veritas".

Authors:
Edgar Pick

Methods Mol Biol 2014 ;1124:339-403

The Julius Friedrich Cohnheim-Minerva Center for Phagocyte Research and the Ela Kodesz Institute of Host Defense against Infectious Diseases, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.

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http://dx.doi.org/10.1007/978-1-62703-845-4_22DOI Listing
October 2014
4 Reads

Two CGD Families with a Hypomorphic Mutation in the Activation Domain of p67.

J Clin Cell Immunol 2014 Jun;5(3)

Departments of Pediatrics (Hematology/Oncology), Microbiology/Immunology, and Medical and Molecular Genetics, Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, IN, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4414043PMC
June 2014
29 Reads

Strategies for identifying synthetic peptides to act as inhibitors of NADPH oxidases, or "all that you did and did not want to know about Nox inhibitory peptides".

Cell Mol Life Sci 2012 Jul 6;69(14):2283-305. Epub 2012 May 6.

The Julius Friedrich Cohnheim Laboratory of Phagocyte Research, Department of Clinical Microbiology and Immunology, Sackler School of Medicine, Tel Aviv University, Israel.

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http://dx.doi.org/10.1007/s00018-012-1007-4DOI Listing
July 2012
29 Reads
5.808 Impact Factor

Inhibition of NADPH oxidase activation by peptides mapping within the dehydrogenase region of Nox2-A "peptide walking" study.

J Leukoc Biol 2012 Mar 19;91(3):501-15. Epub 2011 Dec 19.

Department of Clinical Microbiology and Immunology, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.

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http://dx.doi.org/10.1189/jlb.1011507DOI Listing
March 2012
12 Reads
4.289 Impact Factor

Rational design of small molecule inhibitors targeting the Rac GTPase-p67(phox) signaling axis in inflammation.

Chem Biol 2012 Feb;19(2):228-42

Division of Experimental Hematology and Cancer Biology, Children's Hospital Medical Center, Cincinnati, OH 45229, USA.

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http://dx.doi.org/10.1016/j.chembiol.2011.12.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3292765PMC
February 2012
1 Read
6.645 Impact Factor

A prenylated p47phox-p67phox-Rac1 chimera is a Quintessential NADPH oxidase activator: membrane association and functional capacity.

J Biol Chem 2010 Aug 7;285(33):25485-99. Epub 2010 Jun 7.

Julius Friedrich Cohnheim Laboratory of Phagocyte Research, Department of Clinical Microbiology and Immunology, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M110.113779
Publisher Site
http://dx.doi.org/10.1074/jbc.M110.113779DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2919112PMC
August 2010
16 Reads
4.573 Impact Factor

Editorial: When charge is in charge--"Millikan" for leukocyte biologists.

Authors:
Edgar Pick

J Leukoc Biol 2010 Apr;87(4):537-40

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http://dx.doi.org/10.1189/jlb.1109710DOI Listing
April 2010
4 Reads
4.289 Impact Factor

Dissociation of Rac1(GDP).RhoGDI complexes by the cooperative action of anionic liposomes containing phosphatidylinositol 3,4,5-trisphosphate, Rac guanine nucleotide exchange factor, and GTP.

J Biol Chem 2008 Aug 27;283(32):22257-71. Epub 2008 May 27.

Julius Friedrich Cohnheim-Minerva Center for Phagocyte Research and the Ela Kodesz Institute of Host Defense against Infectious Diseases, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel.

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http://dx.doi.org/10.1074/jbc.M800734200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2494937PMC
August 2008
4 Reads
4.573 Impact Factor

Cell-free assays: the reductionist approach to the study of NADPH oxidase assembly, or "all you wanted to know about cell-free assays but did not dare to ask".

Methods Mol Biol 2007 ;412:385-428

The Julius Friedrich Cohnheim-Minerva Center for Phagocyte Research, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.

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http://dx.doi.org/10.1007/978-1-59745-467-4_25DOI Listing
June 2008
10 Reads

Characterization of surface structure and p47phox SH3 domain-mediated conformational changes for human neutrophil flavocytochrome b.

Biochemistry 2007 Dec 16;46(49):14291-304. Epub 2007 Nov 16.

Department of Microbiology, 109 Lewis Hall, Montana State University, Bozeman, Montana 59717, USA.

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http://dx.doi.org/10.1021/bi701626pDOI Listing
December 2007
11 Reads
3.015 Impact Factor

Opening the black box: lessons from cell-free systems on the phagocyte NADPH-oxidase.

Biochimie 2007 Sep 12;89(9):1123-32. Epub 2007 Mar 12.

Institut de Biologie Structurale Jean-Pierre Ebel, 41 rue Jules Horowitz, F-38027 Grenoble; CEA;CNRS; Université Joseph Fourier; France.

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http://dx.doi.org/10.1016/j.biochi.2007.03.002DOI Listing
September 2007
6 Reads
2.963 Impact Factor

Tripartite chimeras comprising functional domains derived from the cytosolic NADPH oxidase components p47phox, p67phox, and Rac1 elicit activator-independent superoxide production by phagocyte membranes: an essential role for anionic membrane phospholipids.

J Biol Chem 2007 Jul 4;282(30):22122-39. Epub 2007 Jun 4.

Julius Friedrich Cohnheim-Minerva Center for Phagocyte Research and the Ela Kodesz Institute of Host Defense against Infectious Diseases, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.

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http://dx.doi.org/10.1074/jbc.M701497200DOI Listing
July 2007
3 Reads
4.573 Impact Factor

Liposomes comprising anionic but not neutral phospholipids cause dissociation of Rac(1 or 2) x RhoGDI complexes and support amphiphile-independent NADPH oxidase activation by such complexes.

J Biol Chem 2006 Jul 15;281(28):19204-19. Epub 2006 May 15.

Julius Friedrich Cohnheim-Minerva Center for Phagocyte Research and the Ela Kodesz Institute of Host Defense against Infectious Diseases, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel.

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http://dx.doi.org/10.1074/jbc.M600042200DOI Listing
July 2006
3 Reads
4.573 Impact Factor

Bridging the divide or deepening it?

Authors:
Edgar Pick

Science 2006 Jul;313(5784):169-70

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http://dx.doi.org/10.1126/science.313.5784.169cDOI Listing
July 2006
2 Reads
31.477 Impact Factor

Assembly of the phagocyte NADPH oxidase complex: chimeric constructs derived from the cytosolic components as tools for exploring structure-function relationships.

J Leukoc Biol 2006 May;79(5):881-95

The Julius Friedrich Cohnheim-Minerva Center for Phagocyte Research and Ela Kodesz Institute of Host Defense against Infectious Diseases, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.

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http://doi.wiley.com/10.1189/jlb.1005553
Publisher Site
http://dx.doi.org/10.1189/jlb.1005553DOI Listing
May 2006
9 Reads
4.289 Impact Factor

Activation of the phagocyte NADPH oxidase by Rac Guanine nucleotide exchange factors in conjunction with ATP and nucleoside diphosphate kinase.

J Biol Chem 2005 Feb 19;280(5):3802-11. Epub 2004 Nov 19.

Julius Friedrich Cohnheim-Minerva Center for Phagocyte Research and the Ela Kodesz Institute of Host Defense against Infectious Diseases, Sackler School of Medicine, Tel Aviv University, PO Box 39040, Tel Aviv 69978, Israel.

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http://dx.doi.org/10.1074/jbc.M410257200DOI Listing
February 2005
2 Reads
4.573 Impact Factor

Dual role of Rac in the assembly of NADPH oxidase, tethering to the membrane and activation of p67phox: a study based on mutagenesis of p67phox-Rac1 chimeras.

J Biol Chem 2004 Apr 3;279(16):16007-16. Epub 2004 Feb 3.

Julius Friedrich Cohnheim-Minerva Center for Phagocyte Research and the Ela Kodesz Institute of Host Defense against Infectious Diseases, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel.

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http://dx.doi.org/10.1074/jbc.M312394200DOI Listing
April 2004
5 Reads
4.573 Impact Factor

Two pathways of activation of the superoxide-generating NADPH oxidase of phagocytes in vitro--distinctive effects of inhibitors.

Inflammation 2003 Jun;27(3):147-59

Julius Friedrich Cohnheim-Minerva Center for Phagocyte Research, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.

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http://dx.doi.org/10.1023/a:1023869828688DOI Listing
June 2003
2 Reads
1.921 Impact Factor

The guanine nucleotide exchange factor trio activates the phagocyte NADPH oxidase in the absence of GDP to GTP exchange on Rac. "The emperor's nw clothes".

J Biol Chem 2003 Feb 9;278(7):4854-61. Epub 2002 Dec 9.

Julius Friedrich Cohnheim-Minerva Center for Phagocyte Research, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel.

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http://dx.doi.org/10.1074/jbc.M211011200DOI Listing
February 2003
5 Reads
4.573 Impact Factor

A prenylated p67phox-Rac1 chimera elicits NADPH-dependent superoxide production by phagocyte membranes in the absence of an activator and of p47phox: conversion of a pagan NADPH oxidase to monotheism.

J Biol Chem 2002 May 14;277(21):18605-10. Epub 2002 Mar 14.

Julius Friedrich Cohnheim-Minerva Center for Phagocyte Research, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel.

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http://dx.doi.org/10.1074/jbc.M202114200DOI Listing
May 2002
3 Reads
4.573 Impact Factor

Mapping of functional domains in the p22(phox) subunit of flavocytochrome b(559) participating in the assembly of the NADPH oxidase complex by "peptide walking".

J Biol Chem 2002 Mar 3;277(10):8421-32. Epub 2001 Dec 3.

Julius Friedrich Cohnheim-Minerva Center for Phagocyte Research and the Ela Kodesz Institute of Host Defense against Infectious Diseases, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel.

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http://dx.doi.org/10.1074/jbc.M109778200DOI Listing
March 2002
21 Reads
4.573 Impact Factor

Glucosylation and ADP ribosylation of rho proteins: effects on nucleotide binding, GTPase activity, and effector coupling.

Biochemistry 1998 Apr;37(15):5296-304

Institut für Pharmakologie und Toxikologie der Albert-Ludwigs-Universität Freiburg, Hermann-Herder-Strasse 5, D-79104 Freiburg, Germany.

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http://dx.doi.org/10.1021/bi972592cDOI Listing
April 1998
3.015 Impact Factor

Top co-authors

Yevgeny Berdichevsky
Yevgeny Berdichevsky

Tel Aviv University

11
Iris Dahan
Iris Dahan

Sackler School of Medicine

8
Ariel Mizrahi
Ariel Mizrahi

Julius Friedrich Cohnheim Laboratory of Phagocyte Research

7
Shahar Molshanski-Mor
Shahar Molshanski-Mor

Sackler School of Medicine

7
Carolyn Weinbaum
Carolyn Weinbaum

Sackler School of Medicine

6
Yara Gorzalczany
Yara Gorzalczany

Julius Friedrich Cohnheim-Minerva Center for Phagocyte Research

6
Yelena Ugolev
Yelena Ugolev

Tel Aviv University

5
Edna Bechor
Edna Bechor

The Julius Friedrich Cohnheim Laboratory of Phagocyte Research

5
Natalia Sigal
Natalia Sigal

Tel Aviv University

4
Miriam Hirshberg
Miriam Hirshberg

Sackler School of Medicine

4