Eckhard Mandelkow

Eckhard Mandelkow

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Eckhard Mandelkow

Publications by authors named "Eckhard Mandelkow"

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Purification and Characterization of Low-n Tau Oligomers.

Methods Mol Biol 2018 ;1779:99-111

German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.

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http://dx.doi.org/10.1007/978-1-4939-7816-8_8DOI Listing
July 2019

Residue-specific identification of phase separation hot spots of Alzheimer's-related protein tau.

Chem Sci 2019 Jul 22;10(26):6503-6507. Epub 2019 May 22.

Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE) , Von-Siebold-Str. 3a , 37075 Göttingen , Germany . Email:

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http://dx.doi.org/10.1039/c9sc00531eDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6610569PMC
July 2019

Suppressing Tau Aggregation and Toxicity by an Anti-Aggregant Tau Fragment.

Mol Neurobiol 2019 May 8;56(5):3751-3767. Epub 2018 Sep 8.

German Center for Neurodegenerative Diseases (DZNE), Sigmund-Freud-Str. 27, 53127, Bonn, Germany.

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http://dx.doi.org/10.1007/s12035-018-1326-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6476873PMC
May 2019

Screening of a neuronal cell model of tau pathology for therapeutic compounds.

Neurobiol Aging 2019 04 13;76:24-34. Epub 2018 Dec 13.

DZNE, German Center for Neurodegenerative Diseases, Bonn, Germany; CAESAR Research Institute/Max-Planck-Inst., Bonn, Germany; Max-Planck-Inst. Metabolism Res, Hamburg Outstation @ DESY, Hamburg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2018.11.026DOI Listing
April 2019

Functional networks are impaired by elevated tau-protein but reversible in a regulatable Alzheimer's disease mouse model.

Mol Neurodegener 2019 03 27;14(1):13. Epub 2019 Mar 27.

In-vivo-NMR Laboratory, Max Planck Institute for Metabolism Research, Gleuelerstrasse 50, D-50931, Cologne, Germany.

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http://dx.doi.org/10.1186/s13024-019-0316-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438042PMC
March 2019

Mechanisms of Axonal Sorting of Tau and Influence of the Axon Initial Segment on Tau Cell Polarity.

Adv Exp Med Biol 2019 ;1184:69-77

German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.

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http://dx.doi.org/10.1007/978-981-32-9358-8_6DOI Listing
January 2019

Structural Basis of Small Molecule Targetability of Monomeric Tau Protein.

ACS Chem Neurosci 2018 12 16;9(12):2997-3006. Epub 2018 Jul 16.

MTA-TTK-NAP B - Drug Discovery Research Group - Neurodegenerative Diseases, Institute of Organic Chemistry, Research Center for Natural Sciences , Hungarian Academy of Sciences , 1245 Budapest , Hungary.

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http://dx.doi.org/10.1021/acschemneuro.8b00182DOI Listing
December 2018

Glutamatergic nervous system degeneration in a C. elegans Tau tauopathy model involves pathways of excitotoxicity and Ca dysregulation.

Neurobiol Dis 2018 09 9;117:189-202. Epub 2018 Jun 9.

German Center for Neurodegenerative Diseases (DZNE), Sigmund-Freud St. 27, 53127 Bonn, Germany; Max-Planck-Institute for Metabolism Research, Hamburg Outstation, c/o DESY, Notkestrsse 85, 22607 Hamburg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2018.06.005DOI Listing
September 2018

Reversible Cation-Selective Attachment and Self-Assembly of Human Tau on Supported Brain Lipid Membranes.

Nano Lett 2018 05 17;18(5):3271-3281. Epub 2018 Apr 17.

Department of Biosystems Science and Engineering , Eidgenössische Technische Hochschule (ETH) Zurich , Mattenstrasse 26 , 4058 Basel , Switzerland.

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http://dx.doi.org/10.1021/acs.nanolett.8b01085DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6588182PMC
May 2018

Inhibition of Tau Protein Aggregation by Rhodanine-based Compounds Solubilized Via Specific Formulation Additives to Improve Bioavailability and Cell Viability.

Curr Alzheimer Res 2017 ;14(7):742-752

CAESAR Research Institute, Ludwig- Erhard-Allee, 2, 53175; Max-Planck-Institute for Metabolism Research, Gleuerlerstr. 50, 50931 Koln. Germany.

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http://dx.doi.org/10.2174/1567205014666170202103136DOI Listing
April 2018

The Binding Mode of a Tau Peptide with Tubulin.

Angew Chem Int Ed Engl 2018 03 22;57(12):3246-3250. Epub 2018 Feb 22.

German Center for Neurodegenerative Diseases (DZNE), Von-Siebold Strasse 3a, 37075, Goettingen, Germany.

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http://doi.wiley.com/10.1002/anie.201712089
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http://dx.doi.org/10.1002/anie.201712089DOI Listing
March 2018

Interplay of pathogenic forms of human tau with different autophagic pathways.

Aging Cell 2018 02 12;17(1). Epub 2017 Oct 12.

Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY, 10461, USA.

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http://dx.doi.org/10.1111/acel.12692DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5770880PMC
February 2018

models of tauopathy.

FASEB J 2017 12;31(12):5137-5148

German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.

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http://dx.doi.org/10.1096/fj.201701007DOI Listing
December 2017

Anti-aggregant tau mutant promotes neurogenesis.

Mol Neurodegener 2017 12 4;12(1):88. Epub 2017 Dec 4.

German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.

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http://dx.doi.org/10.1186/s13024-017-0230-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5715613PMC
December 2017

Multivalent cross-linking of actin filaments and microtubules through the microtubule-associated protein Tau.

Nat Commun 2017 12 7;8(1):1981. Epub 2017 Dec 7.

Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Von-Siebold-Strasse 3a, 37075, Göttingen, Germany.

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http://dx.doi.org/10.1038/s41467-017-02230-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5719408PMC
December 2017

What is the evidence that tau pathology spreads through prion-like propagation?

Acta Neuropathol Commun 2017 Dec 19;5(1):99. Epub 2017 Dec 19.

Laboratory of Histology, Neuroanatomy and Neuropathology Université Libre de Bruxelles, Faculty of Medicine, ULB Neuroscience Institute (UNI) 808, route de Lennik 1070, Brussels, Belgium.

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http://dx.doi.org/10.1186/s40478-017-0488-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5735872PMC
December 2017

Extracellular low-n oligomers of tau cause selective synaptotoxicity without affecting cell viability.

Alzheimers Dement 2017 Nov 18;13(11):1270-1291. Epub 2017 May 18.

DZNE, German Center for Neurodegenerative Diseases, Bonn, Germany; MPI for Metabolism Research, Hamburg, Germany; CAESAR Research Center, Bonn, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jalz.2017.04.002DOI Listing
November 2017

Gaining Insights into Specific Drug Formulation Additives for Solubilizing a Potential Anti-Alzheimer Disease Drug B4A1.

Macromol Biosci 2017 10 10;17(10). Epub 2017 May 10.

Department of Chemistry, Laboratory for Organic Synthesis of Functional Systems, Humboldt-Universität zu Berlin, Brook-Taylor-Str. 2, 12489, Berlin, Germany.

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http://dx.doi.org/10.1002/mabi.201700109DOI Listing
October 2017

Time course of Tau toxicity and pharmacologic prevention in a cell model of Tauopathy.

Neurobiol Aging 2017 09 3;57:47-63. Epub 2017 May 3.

DZNE, German Center for Neurodegenerative Diseases, Bonn, Germany; CAESAR Research Institute, Bonn, Germany; Max-Planck-Institute for Metabolism Research, Köln, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2017.04.022DOI Listing
September 2017

Liquid-liquid phase separation of the microtubule-binding repeats of the Alzheimer-related protein Tau.

Nat Commun 2017 08 17;8(1):275. Epub 2017 Aug 17.

Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), von-Siebold-Str. 3a, 37075, Göttingen, Germany.

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http://dx.doi.org/10.1038/s41467-017-00480-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5561136PMC
August 2017

A Two-Component Adhesive: Tau Fibrils Arise from a Combination of a Well-Defined Motif and Conformationally Flexible Interactions.

J Am Chem Soc 2017 02 8;139(7):2639-2646. Epub 2017 Feb 8.

Department NMR-Based Structural Biology, Max-Planck Institute for Biophysical Chemistry , Am Fassberg 11, 37077 Göttingen, Germany.

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http://pubs.acs.org/doi/10.1021/jacs.6b09619
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http://dx.doi.org/10.1021/jacs.6b09619DOI Listing
February 2017

Adenosine A1 receptor antagonist rolofylline alleviates axonopathy caused by human Tau ΔK280.

Proc Natl Acad Sci U S A 2016 10 26;113(41):11597-11602. Epub 2016 Sep 26.

German Center for Neurodegenerative Diseases, 53127 Bonn, Germany; Center of Advanced European Studies and Research, 53175 Bonn, Germany; Max Planck Institute for Metabolism Research, 22607 Hamburg, Germany

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http://dx.doi.org/10.1073/pnas.1603119113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5068267PMC
October 2016

Generalizing the Concept of Specific Compound Formulation Additives towards Non-Fluorescent Drugs: A Solubilization Study on Potential Anti-Alzheimer-Active Small-Molecule Compounds.

Angew Chem Int Ed Engl 2016 07 10;55(30):8752-6. Epub 2016 Jun 10.

Humboldt-Universität zu Berlin, Department of Chemistry, Brook-Taylor-Strasse 2, 12489, Berlin, Germany.

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http://dx.doi.org/10.1002/anie.201601147DOI Listing
July 2016

Remodeling of the conformational ensemble of the repeat domain of tau by an aggregation enhancer.

Protein Sci 2016 May 24;25(5):1010-20. Epub 2016 Mar 24.

Department for NMR-based Structural Biology, Max Planck Institute for Biophysical Chemistry, Göttingen, 37077, Germany.

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http://dx.doi.org/10.1002/pro.2911DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4838641PMC
May 2016

FLEXITau: Quantifying Post-translational Modifications of Tau Protein in Vitro and in Human Disease.

Anal Chem 2016 Apr 7;88(7):3704-14. Epub 2016 Mar 7.

F. M. Kirby Neurobiology Center, Boston Children's Hospital , Boston, Massachusetts 02115, United States.

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http://dx.doi.org/10.1021/acs.analchem.5b04509DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5808556PMC
April 2016

The Tau/A152T mutation, a risk factor for frontotemporal-spectrum disorders, leads to NR2B receptor-mediated excitotoxicity.

EMBO Rep 2016 04 1;17(4):552-69. Epub 2016 Mar 1.

German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany Max-Planck-Institute for Metabolism Research (Cologne), Hamburg Outstation, Hamburg, Germany Caesar Research Center, Bonn, Germany

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http://dx.doi.org/10.15252/embr.201541439DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4818782PMC
April 2016

Tau mutant A152T, a risk factor for FTD/PSP, induces neuronal dysfunction and reduced lifespan independently of aggregation in a C. elegans Tauopathy model.

Mol Neurodegener 2016 Apr 27;11:33. Epub 2016 Apr 27.

German Center for Neurodegenerative Diseases (DZNE), Ludwig-Erhard-Allee 2, 53175, Bonn, Germany.

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http://dx.doi.org/10.1186/s13024-016-0096-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4847334PMC
April 2016

Backbone assignment for minimal protein amounts of low structural homogeneity in the absence of deuteration.

Chem Commun (Camb) 2016 Mar;52(21):4002-5

Max-Planck Institute for Biophysical Chemistry, Department NMR-Based Structural Biology, Am Fassberg 11, 37077 Göttingen, Germany.

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http://dx.doi.org/10.1039/c5cc09160hDOI Listing
March 2016

Acetylation mimic of lysine 280 exacerbates human Tau neurotoxicity in vivo.

Sci Rep 2016 Mar 4;6:22685. Epub 2016 Mar 4.

Max Planck Institute for Biology of Ageing, Joseph-Stelzmann-Strasse 9b, 50931 Cologne, Germany; CECAD Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases, 50931 Cologne, Germany.

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http://dx.doi.org/10.1038/srep22685DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4778021PMC
March 2016

Tau in physiology and pathology.

Nat Rev Neurosci 2016 Jan 3;17(1):5-21. Epub 2015 Dec 3.

German Center for Neurodegenerative Diseases (DZNE), 53175 Bonn, Germany.

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http://dx.doi.org/10.1038/nrn.2015.1DOI Listing
January 2016

Folding of the Tau Protein on Microtubules.

Angew Chem Int Ed Engl 2015 Aug 19;54(35):10347-51. Epub 2015 Jun 19.

Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, 37077 Göttingen (Germany).

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http://dx.doi.org/10.1002/anie.201501714DOI Listing
August 2015

Structural Impact of Tau Phosphorylation at Threonine 231.

Structure 2015 Aug 9;23(8):1448-1458. Epub 2015 Jul 9.

German Center for Neurodegenerative Diseases (DZNE), 37077 Göttingen, Germany; Department for NMR-based Structural Biology, Max Planck Institute for Biophysical Chemistry, 37077 Göttingen, Germany; DFG Research Center for Nanoscale Microscopy and Molecular Physiology of the Brain (CNMPB), University Medical Center Göttingen, 37073 Göttingen, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.str.2015.06.002DOI Listing
August 2015

Tau stabilizes microtubules by binding at the interface between tubulin heterodimers.

Proc Natl Acad Sci U S A 2015 Jun 1;112(24):7501-6. Epub 2015 Jun 1.

Max Planck Institute for Biophysical Chemistry, 37077 Göttingen, Germany; Deutsches Zentrum für Neurodegenerative Erkrankungen, 37077 Göttingen, Germany; Center for Nanoscale Microscopy and Molecular Physiology of the Brain, University Medical Center, 37075 Göttingen, Germany

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http://dx.doi.org/10.1073/pnas.1504081112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4475932PMC
June 2015

Lost after translation: missorting of Tau protein and consequences for Alzheimer disease.

Trends Neurosci 2014 Dec 12;37(12):721-32. Epub 2014 Sep 12.

German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany; Center of Advanced European Studies and Research (CAESAR), Bonn, Germany; Max Planck Institute for Neurological Research, Hamburg Outstation, c/o Deutsches Elektronen-Synchrotron (DESY), Hamburg, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01662236140013
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http://dx.doi.org/10.1016/j.tins.2014.08.004DOI Listing
December 2014

Oligomer formation of tau protein hyperphosphorylated in cells.

J Biol Chem 2014 Dec 22;289(49):34389-407. Epub 2014 Oct 22.

From the DZNE, German Center for Neurodegenerative Diseases, 53175 Bonn, Germany, the CAESAR Research Center, 53175 Bonn, Germany,

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http://www.jbc.org/content/289/49/34389.full.pdf
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http://www.jbc.org/lookup/doi/10.1074/jbc.M114.611368
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http://dx.doi.org/10.1074/jbc.M114.611368DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4256367PMC
December 2014

Transport and diffusion of Tau protein in neurons.

Cell Mol Life Sci 2014 Aug 1;71(16):3139-50. Epub 2014 Apr 1.

Institute for Molecular and Cell Physiology, Hannover Medical School, Carl-Neuberg-Strasse 1, 30625, Hannover, Germany,

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http://dx.doi.org/10.1007/s00018-014-1610-7DOI Listing
August 2014

Alternative conformations of the Tau repeat domain in complex with an engineered binding protein.

J Biol Chem 2014 Aug 25;289(33):23209-18. Epub 2014 Jun 25.

From the Institute of Physical Biology, Heinrich-Heine-Universität, 40204 Düsseldorf, Germany, the Institute of Structural Biochemistry (ICS-6), Research Centre Jülich, 52425 Jülich, Germany,

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http://www.jbc.org/content/289/33/23209.full.pdf
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http://www.jbc.org/content/early/2014/06/25/jbc.M114.560920.
Web Search
http://www.jbc.org/cgi/doi/10.1074/jbc.M114.560920
Publisher Site
http://dx.doi.org/10.1074/jbc.M114.560920DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4132818PMC
August 2014

Stages and conformations of the Tau repeat domain during aggregation and its effect on neuronal toxicity.

J Biol Chem 2014 Jul 13;289(29):20318-32. Epub 2014 May 13.

From the German Center for Neurodegenerative Diseases (DZNE), 53175 Bonn, Germany, the Max Planck Institute for Neurological Research, Hamburg Outstation, c/o DESY, 22607 Hamburg, Germany, and the Center of Advanced European Studies and Research (CAESAR), 53175 Bonn, Germany,

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http://dx.doi.org/10.1074/jbc.M114.554725DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4106345PMC
July 2014

Predictive atomic resolution descriptions of intrinsically disordered hTau40 and α-synuclein in solution from NMR and small angle scattering.

Structure 2014 Feb 19;22(2):238-49. Epub 2013 Dec 19.

University Grenoble Alpes, Protein Dynamics and Flexibility, Institut de Biologie Structurale, 38000 Grenoble, France; CNRS, Protein Dynamics and Flexibility, Institut de Biologie Structurale, 38000 Grenoble, France; CEA, DSV, Protein Dynamics and Flexibility, Institut de Biologie Structurale, 38000 Grenoble, France. Electronic address:

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http://dx.doi.org/10.1016/j.str.2013.10.020DOI Listing
February 2014

Extracellular monomeric tau protein is sufficient to initiate the spread of tau protein pathology.

J Biol Chem 2014 Jan 14;289(2):956-67. Epub 2013 Nov 14.

From the Department of Chemical Engineering and Biotechnology, University of Cambridge, Pembroke Street, Cambridge CB2 3RA, United Kingdom.

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http://dx.doi.org/10.1074/jbc.M113.515445DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3887218PMC
January 2014

Phosphorylation of human Tau protein by microtubule affinity-regulating kinase 2.

Biochemistry 2013 Dec 22;52(50):9068-79. Epub 2013 Nov 22.

German Center for Neurodegenerative Diseases (DZNE) , 37077 Göttingen, Germany.

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http://dx.doi.org/10.1021/bi401266nDOI Listing
December 2013

Progress and developments in tau aggregation inhibitors for Alzheimer disease.

J Med Chem 2013 Jun 13;56(11):4135-55. Epub 2013 Mar 13.

Laboratory of Organic Synthesis of Functional Systems, Humboldt-Universität zu Berlin, Brook-Taylor-Strasse 2, 12489 Berlin, Germany.

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http://pubs.acs.org/doi/10.1021/jm3017317
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http://dx.doi.org/10.1021/jm3017317DOI Listing
June 2013

Cascade of tau toxicity in inducible hippocampal brain slices and prevention by aggregation inhibitors.

Neurobiol Aging 2013 May 15;34(5):1343-1354. Epub 2012 Nov 15.

German Center for Neurodegenerative Diseases (DZNE), Ludwig-Erhard-Allee 2, 53175 Bonn, Germany.

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http://dx.doi.org/10.1016/j.neurobiolaging.2012.10.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4984976PMC
May 2013

Imbalance of Hsp70 family variants fosters tau accumulation.

FASEB J 2013 Apr 27;27(4):1450-9. Epub 2012 Dec 27.

Department of Pharmaceutical Sciences, University of South Florida Health Byrd Alzheimer's Institute, University of South Florida, Tampa, Florida 33613, USA.

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http://dx.doi.org/10.1096/fj.12-220889DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3606536PMC
April 2013

Mechanistic basis of phenothiazine-driven inhibition of Tau aggregation.

Angew Chem Int Ed Engl 2013 Mar 11;52(12):3511-5. Epub 2013 Feb 11.

Max-Planck-Institut für Biophysikalische Chemie, Am Fassberg 11, 37077 Göttingen, Germany.

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http://dx.doi.org/10.1002/anie.201208290DOI Listing
March 2013

Inhibition of tau filament formation by conformational modulation.

J Am Chem Soc 2013 Feb 5;135(7):2853-62. Epub 2013 Feb 5.

Department for NMR-based Structural Biology, Max Planck Institute for Biophysical Chemistry, 37077 Göttingen, Germany.

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http://dx.doi.org/10.1021/ja312471hDOI Listing
February 2013

The fuzzy coat of pathological human Tau fibrils is a two-layered polyelectrolyte brush.

Proc Natl Acad Sci U S A 2013 Jan 26;110(4):E313-21. Epub 2012 Dec 26.

Department of Biosystems Science and Engineering, Eidgenössiche Technische Hochschule Zürich, 4058 Basel, Switzerland.

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http://dx.doi.org/10.1073/pnas.1212100110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3557036PMC
January 2013

Tau protein diffuses along the microtubule lattice.

J Biol Chem 2012 Nov 27;287(46):38559-68. Epub 2012 Sep 27.

Institute for Molecular and Cell Physiology, Hannover Medical School, Carl-Neuberg-Strasse 1, 30625 Hannover, Germany.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M112.369785
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http://dx.doi.org/10.1074/jbc.M112.369785DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3493901PMC
November 2012

Alzheimer disease in 2020.

Cold Spring Harb Perspect Med 2012 Nov 1;2(11). Epub 2012 Nov 1.

Department of Neurology, Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

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http://dx.doi.org/10.1101/cshperspect.a011585DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3543098PMC
November 2012

Conformations of microtubule-associated protein Tau mapped by fluorescence resonance energy transfer.

Methods Mol Biol 2012 ;849:85-99

Max-Planck-Unit for Structural Molecular Biology c/o DESY, Hamburg, Germany.

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http://dx.doi.org/10.1007/978-1-61779-551-0_7DOI Listing
August 2012

Investigating fibrillar aggregates of Tau protein by atomic force microscopy.

Methods Mol Biol 2012 ;849:169-83

Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland.

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http://dx.doi.org/10.1007/978-1-61779-551-0_12DOI Listing
August 2012

Evidence for a role of the rare p.A152T variant in MAPT in increasing the risk for FTD-spectrum and Alzheimer's diseases.

Hum Mol Genet 2012 Aug 3;21(15):3500-12. Epub 2012 May 3.

Department of Neurology, University of California, Los Angeles, CA, USA.

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http://dx.doi.org/10.1093/hmg/dds161DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3392107PMC
August 2012

Inhibition of tau aggregation in a novel Caenorhabditis elegans model of tauopathy mitigates proteotoxicity.

Hum Mol Genet 2012 Aug 18;21(16):3587-603. Epub 2012 May 18.

Institute of Biology III, University of Freiburg, 79104 Freiburg, Germany.

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http://dx.doi.org/10.1093/hmg/dds190DOI Listing
August 2012

Degradation of tau protein by autophagy and proteasomal pathways.

Biochem Soc Trans 2012 Aug;40(4):644-52

German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.

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http://dx.doi.org/10.1042/BST20120071DOI Listing
August 2012

β-Sheet core of tau paired helical filaments revealed by solid-state NMR.

J Am Chem Soc 2012 Aug 15;134(34):13982-9. Epub 2012 Aug 15.

NMR-based Structural Biology, Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, 37077 Göttingen, Germany.

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http://dx.doi.org/10.1021/ja305470pDOI Listing
August 2012

Biochemistry and cell biology of tau protein in neurofibrillary degeneration.

Cold Spring Harb Perspect Med 2012 Jul;2(7):a006247

Max-Planck Unit for Structural Molecular Biology, c/o DESY, 22607 Hamburg, Germany; DZNE, German Center for Neurodegenerative Diseases, and CAESAR Research Center, 53175 Bonn, Germany.

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http://dx.doi.org/10.1101/cshperspect.a006247DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3385935PMC
July 2012

N'-benzylidene-benzohydrazides as novel and selective tau-PHF ligands.

J Alzheimers Dis 2011 ;27(4):835-43

Clemens Schöpf-Institute of Chemistry and Biochemistry, Technische Universtität Darmstadt, Darmstadt, Germany.

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http://dx.doi.org/10.3233/JAD-2011-111238DOI Listing
April 2012

Interaction of tau protein with model lipid membranes induces tau structural compaction and membrane disruption.

Biochemistry 2012 Mar 14;51(12):2539-50. Epub 2012 Mar 14.

Department of Chemical and Nuclear Engineering, Center for Biomedical Engineering, University of New Mexico, Albuquerque, New Mexico 87131, United States.

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http://dx.doi.org/10.1021/bi201857vDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3319454PMC
March 2012

Deciphering Alzheimer disease.

Cold Spring Harb Perspect Med 2012 Jan;2(1):a011460

Center for Neurologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1101/cshperspect.a011460DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3253026PMC
January 2012

"Lest we forget you--methylene blue...".

Neurobiol Aging 2011 Dec 12;32(12):2325.e7-16. Epub 2011 Feb 12.

Center of Biochemistry (BZH), University of Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.neurobiolaging.2010.12.012DOI Listing
December 2011

The dynamic structure of filamentous tau.

Angew Chem Int Ed Engl 2011 Nov 11;50(48):11520-4. Epub 2011 Oct 11.

Department of NMR-based Structural Biology, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany.

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http://dx.doi.org/10.1002/anie.201105493DOI Listing
November 2011

Structural impact of proline-directed pseudophosphorylation at AT8, AT100, and PHF1 epitopes on 441-residue tau.

J Am Chem Soc 2011 Oct 15;133(40):15842-5. Epub 2011 Sep 15.

Department of NMR-based Structural Biology, Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, 37077 Göttingen, Germany.

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http://pubs.acs.org/doi/abs/10.1021/ja205836j
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October 2011

Novel diffusion barrier for axonal retention of Tau in neurons and its failure in neurodegeneration.

EMBO J 2011 Oct 18;30(23):4825-37. Epub 2011 Oct 18.

Max-Planck-Unit for Structural Molecular Biology, c/o DESY, Hamburg, Germany.

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http://dx.doi.org/10.1038/emboj.2011.376DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3243615PMC
October 2011

Structural memory of natively unfolded tau protein detected by small-angle X-ray scattering.

Proteins 2011 Jul 10;79(7):2122-31. Epub 2011 May 10.

European Molecular Biology Laboratory, Hamburg Outstation c/o DESY, Notkestrasse 85, 22603 Hamburg, Germany.

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http://dx.doi.org/10.1002/prot.23033DOI Listing
July 2011

Tau protein and tau aggregation inhibitors.

Neuropharmacology 2010 Sep-Oct;59(4-5):276-89. Epub 2010 Feb 10.

Center for Advanced European Studies and Research, Bonn, Germany.

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http://dx.doi.org/10.1016/j.neuropharm.2010.01.016DOI Listing
June 2011

Competing interactions stabilize pro- and anti-aggregant conformations of human Tau.

J Biol Chem 2011 Jun 15;286(23):20512-24. Epub 2011 Apr 15.

Department of Biosystems Science and Engineering, ETH Zürich, 4058 Basel, Switzerland.

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http://dx.doi.org/10.1074/jbc.M111.237875DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3121454PMC
June 2011

Cleavage of Tau by calpain in Alzheimer's disease: the quest for the toxic 17 kD fragment.

Neurobiol Aging 2011 Jan 18;32(1):1-14. Epub 2010 Oct 18.

Max-Planck-Unit for Structural Molecular Biology, Hamburg, Germany.

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http://dx.doi.org/10.1016/j.neurobiolaging.2010.09.008DOI Listing
January 2011

Automatic assignment of the intrinsically disordered protein Tau with 441-residues.

J Am Chem Soc 2010 Sep;132(34):11906-7

Department of NMR-based Structural Biology, Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, 37077 Goettingen, Germany.

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http://pubs.acs.org/doi/abs/10.1021/ja105657f
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September 2010

Human Tau isoforms assemble into ribbon-like fibrils that display polymorphic structure and stability.

J Biol Chem 2010 Aug 21;285(35):27302-13. Epub 2010 Jun 21.

Department of Biosystems Science and Engineering, ETH Zürich, CH-4058 Basel, Switzerland.

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http://dx.doi.org/10.1074/jbc.M110.145318DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2930729PMC
August 2010

Proteolytic processing of tau.

Biochem Soc Trans 2010 Aug;38(4):955-61

Max-Planck-Unit for Structural Molecular Biology c/o DESY, Notkestrasse 85, 22607 Hamburg, Germany.

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http://dx.doi.org/10.1042/BST0380955DOI Listing
August 2010

Fyn-tau-amyloid: a toxic triad.

Cell 2010 Aug;142(3):356-8

German Center for Neurodegenerative Diseases, 80336 Munich, Germany.

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http://dx.doi.org/10.1016/j.cell.2010.07.032DOI Listing
August 2010

Structures of kinesin motor proteins.

Cell Motil Cytoskeleton 2009 Nov;66(11):958-66

Max-Planck-Unit for Structural Molecular Biology, c/o DESY, Hamburg, Germany.

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http://dx.doi.org/10.1002/cm.20392DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2765580PMC
November 2009

Tau fragmentation, aggregation and clearance: the dual role of lysosomal processing.

Hum Mol Genet 2009 Nov 4;18(21):4153-70. Epub 2009 Aug 4.

Max-Planck-Unit for Structural Molecular Biology, Notkestrasse 85, 22607 Hamburg, Germany.

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http://dx.doi.org/10.1093/hmg/ddp367DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2758146PMC
November 2009

Conformational changes specific for pseudophosphorylation at serine 262 selectively impair binding of tau to microtubules.

Biochemistry 2009 Oct;48(42):10047-55

Department for NMR-Based Structural Biology, Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, 37077 Gottingen, Germany.

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http://dx.doi.org/10.1021/bi901090mDOI Listing
October 2009

Low-power solid-state NMR experiments for resonance assignment under fast magic-angle spinning.

Chemphyschem 2009 Sep;10(13):2205-8

NMR-based Structural Biology, Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, 37077 Göttingen, Germany.

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http://doi.wiley.com/10.1002/cphc.200900439
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September 2009

Development of tau aggregation inhibitors for Alzheimer's disease.

Angew Chem Int Ed Engl 2009 ;48(10):1740-52

Max-Planck-Institute for Molecular Physiology, Dortmund, Germany.

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http://dx.doi.org/10.1002/anie.200802621DOI Listing
April 2009

Structural polymorphism of 441-residue tau at single residue resolution.

PLoS Biol 2009 Feb;7(2):e34

Department for Nuclear Magnetic Resonance (NMR)-Based Structural Biology, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany.

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https://dx.plos.org/10.1371/journal.pbio.1000034
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http://dx.doi.org/10.1371/journal.pbio.1000034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2642882PMC
February 2009