Publications by authors named "Eckart Meese"

100Publications

Competitive learning suggests circulating miRNA profiles for cancers decades prior to diagnosis.

RNA Biol 2020 10 16;17(10):1416-1426. Epub 2020 Jun 16.

Department of Human Genetics, Saarland University , Homburg/Saar, Germany.

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http://dx.doi.org/10.1080/15476286.2020.1771945DOI Listing
October 2020

miRSwitch: detecting microRNA arm shift and switch events.

Nucleic Acids Res 2020 07;48(W1):W268-W274

Chair for Clinical Bioinformatics, Saarland University, 66123 Saarbrücken, Germany.

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http://dx.doi.org/10.1093/nar/gkaa323DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7319450PMC
July 2020

MicroRNA signature in spermatozoa and seminal plasma of proven fertile men and in testicular tissue of men with obstructive azoospermia.

Andrologia 2020 Mar 26;52(2):e13503. Epub 2019 Dec 26.

Institute of Human Genetics, Saarland University, Homburg, Saar, Germany.

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http://dx.doi.org/10.1111/and.13503DOI Listing
March 2020

Machine Learning to Detect Alzheimer's Disease from Circulating Non-coding RNAs.

Genomics Proteomics Bioinformatics 2019 08 4;17(4):430-440. Epub 2019 Dec 4.

Chair for Clinical Bioinformatics, Saarland University, 66123 Saarbrücken, Germany; Center for Bioinformatics, Saarland Informatics Campus, 66123 Saarbrücken, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.gpb.2019.09.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6943763PMC
August 2019

What's the target: understanding two decades of in silico microRNA-target prediction.

Brief Bioinform 2019 Dec 3. Epub 2019 Dec 3.

Chair for Clinical Bioinformatics, Saarland University, Saarbrücken, 66123, Germany and Department of Human Genetics, Saarland University, Homburg, 66424, Germany.

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http://dx.doi.org/10.1093/bib/bbz111DOI Listing
December 2019

miRPathDB 2.0: a novel release of the miRNA Pathway Dictionary Database.

Nucleic Acids Res 2020 01;48(D1):D142-D147

Chair for Clinical Bioinformatics, Saarland University, 66123 Saarbrücken, Germany.

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http://dx.doi.org/10.1093/nar/gkz1022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7145528PMC
January 2020

Micro-RNA 150-5p predicts overt heart failure in patients with univentricular hearts.

PLoS One 2019 10;14(10):e0223606. Epub 2019 Oct 10.

Department of Pediatric Cardiology, Saarland University Medical Center, Homburg/Saar, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0223606PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6786722PMC
March 2020

miR-34a as hub of T cell regulation networks.

J Immunother Cancer 2019 07 16;7(1):187. Epub 2019 Jul 16.

Institute of Human Genetics, Saarland University, Building 60, 66421, Homburg, Germany.

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http://dx.doi.org/10.1186/s40425-019-0670-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6636054PMC
July 2019

Prospect and challenge of detecting dynamic gene copy number increases in stem cells by whole genome sequencing.

J Mol Med (Berl) 2019 08 27;97(8):1099-1111. Epub 2019 May 27.

Department of Human Genetics, Saarland University, Building 60, 66421, Homburg/Saar, Germany.

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http://dx.doi.org/10.1007/s00109-019-01792-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6647207PMC
August 2019

Differential expression of miR-23a/b-3p and its target genes in male patients with subfertility.

Fertil Steril 2019 08 2;112(2):323-335.e2. Epub 2019 May 2.

Institute of Human Genetics, Saarland University, Homburg/Saar, Germany.

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http://dx.doi.org/10.1016/j.fertnstert.2019.03.025DOI Listing
August 2019

MicroRNA profiling from dried blood samples.

Crit Rev Clin Lab Sci 2019 03 29;56(2):111-117. Epub 2019 Jan 29.

a Institute of Human Genetics, Medical Faculty , Saarland University , Homburg , Germany.

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http://dx.doi.org/10.1080/10408363.2018.1561641DOI Listing
March 2019

MicroRNA-regulated pathways of flow-stimulated angiogenesis and vascular remodeling in vivo.

J Transl Med 2019 01 11;17(1):22. Epub 2019 Jan 11.

Department of Hand, Plastic and Reconstructive Surgery, University of Heidelberg, BG Trauma Center Ludwigshafen, Ludwig-Guttmann Str. 13, 67071, Ludwigshafen, Germany.

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https://translational-medicine.biomedcentral.com/articles/10
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http://dx.doi.org/10.1186/s12967-019-1767-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330440PMC
January 2019

Acute Myeloid Leukemia Affects Mouse Sperm Parameters, Spontaneous Acrosome Reaction, and Fertility Capacity.

Int J Mol Sci 2019 Jan 8;20(1). Epub 2019 Jan 8.

The Shraga Segal Department of Microbiology, Immunology, and Genetics, The Center of Advanced Research and Education in Reproduction (CARER), Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel.

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http://www.mdpi.com/1422-0067/20/1/219
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http://dx.doi.org/10.3390/ijms20010219DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337746PMC
January 2019

Next Generation Sequencing Analysis of Total Small Noncoding RNAs from Low Input RNA from Dried Blood Sampling.

Anal Chem 2018 10 25;90(20):11791-11796. Epub 2018 Sep 25.

Molecular Cell Dynamics, Centre for Human and Molecular Biology , Campus A2.4, Saarland University , 66123 Saarbrücken , Germany.

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http://dx.doi.org/10.1021/acs.analchem.8b03557DOI Listing
October 2018

The role of TCF3 as potential master regulator in blastemal Wilms tumors.

Int J Cancer 2019 03 13;144(6):1432-1443. Epub 2018 Nov 13.

Center for Bioinformatics, Saarland Informatics Campus, Saarland University, Saarbrücken, Germany.

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http://doi.wiley.com/10.1002/ijc.31834
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http://dx.doi.org/10.1002/ijc.31834DOI Listing
March 2019

Genome-wide MicroRNA Expression Profiles in COPD: Early Predictors for Cancer Development.

Genomics Proteomics Bioinformatics 2018 06 5;16(3):162-171. Epub 2018 Jul 5.

Department of Internal Medicine V - Pulmonology, Allergology, Intensive Care Medicine, Saarland University Hospital, 66421 Homburg, Germany.

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http://dx.doi.org/10.1016/j.gpb.2018.06.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6076380PMC
June 2018

Micro-RNA-Regulated Proangiogenic Signaling in Arteriovenous Loops in Patients with Combined Vascular and Soft-Tissue Reconstructions: Revisiting the Nutrient Flap Concept.

Plast Reconstr Surg 2018 10;142(4):489e-502e

Ludwigshafen, Homburg-Saar, and Saarbruecken, Germany From the Department of Hand, Plastic, and Reconstructive Surgery, University of Heidelberg, BG Trauma Center Ludwigshafen; the Institute of Human Genetics and the Institute of Clinical Bioinformatics, Saarland University; and the Department of Vascular Surgery, Ludwigshafen Hospital.

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http://dx.doi.org/10.1097/PRS.0000000000004750DOI Listing
October 2018

The deterministic role of 5-mers in microRNA-gene targeting.

RNA Biol 2018 11;15(6):819-825. Epub 2018 May 11.

a Institute of Human Genetics, Saarland University , Homburg , Germany.

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http://dx.doi.org/10.1080/15476286.2018.1462652DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152440PMC
November 2018

Small ncRNA-Seq Results of Human Tissues: Variations Depending on Sample Integrity.

Clin Chem 2018 07 24;64(7):1074-1084. Epub 2018 Apr 24.

Department of Clinical Bioinformatics, Saarland University, Saarbrücken, Germany;

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http://dx.doi.org/10.1373/clinchem.2017.285767DOI Listing
July 2018

Gene amplification in mesenchymal stem cells and during differentiation towards adipocytes or osteoblasts.

Oncotarget 2018 01 1;9(2):1803-1812. Epub 2017 Dec 1.

Department of Human Genetics, Saarland University, 66421 Homburg/Saar, Germany.

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http://dx.doi.org/10.18632/oncotarget.22804DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5788600PMC
January 2018

About miRNAs, miRNA seeds, target genes and target pathways.

Oncotarget 2017 Dec 9;8(63):107167-107175. Epub 2017 Nov 9.

Chair for Clinical Bioinformatics, Saarland University, Saarland Informatics Campus, Saarbrücken, Germany.

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http://dx.doi.org/10.18632/oncotarget.22363DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5739805PMC
December 2017

miRCarta: a central repository for collecting miRNA candidates.

Nucleic Acids Res 2018 01;46(D1):D160-D167

Chair for Clinical Bioinformatics, Saarland Informatics Campus, Saarland University, Germany.

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http://dx.doi.org/10.1093/nar/gkx851DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5753177PMC
January 2018

IMOTA: an interactive multi-omics tissue atlas for the analysis of human miRNA-target interactions.

Nucleic Acids Res 2018 01;46(D1):D770-D775

Chair for Clinical Bioinformatics, Saarland University, 66123 Saarbrücken, Germany.

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http://dx.doi.org/10.1093/nar/gkx701DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5753248PMC
January 2018

Altered miRNA-profile dependent on ART outcome in early pregnancy targets Wnt-pathway.

Reproduction 2017 12 29;154(6):799-805. Epub 2017 Sep 29.

Department of Gynecologic Endocrinology and Fertility Disorders at Heidelberg University Women's HospitalHeidelberg, Germany.

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http://dx.doi.org/10.1530/REP-17-0396DOI Listing
December 2017

MiR-148a impairs Ras/ERK signaling in B lymphocytes by targeting SOS proteins.

Oncotarget 2017 Aug 7;8(34):56417-56427. Epub 2017 May 7.

Institute of Human Genetics, Saarland University, 66421 Homburg, Germany.

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http://dx.doi.org/10.18632/oncotarget.17662DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5593572PMC
August 2017

Sources to variability in circulating human miRNA signatures.

RNA Biol 2017 12 13;14(12):1791-1798. Epub 2017 Sep 13.

c Department of Human Genetics , Saarland University , Homburg , Germany.

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http://dx.doi.org/10.1080/15476286.2017.1367888DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5731815PMC
December 2017

Bias in recent miRBase annotations potentially associated with RNA quality issues.

Sci Rep 2017 07 12;7(1):5162. Epub 2017 Jul 12.

Department of Human Genetics, Saarland University, Homburg, Germany.

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http://dx.doi.org/10.1038/s41598-017-05070-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5507985PMC
July 2017

Analysis of circulating microRNAs in patients with repaired Tetralogy of Fallot with and without heart failure.

J Transl Med 2017 07 10;15(1):156. Epub 2017 Jul 10.

Department of Pediatric Cardiology, Saarland University Medical Center, 66421, Homburg/Saar, Germany.

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http://dx.doi.org/10.1186/s12967-017-1255-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5504636PMC
July 2017

Characterization of micro-RNA Profile in the Blood of Patients with Marfan's Syndrome.

Thorac Cardiovasc Surg 2018 01 5;66(1):116-124. Epub 2017 Jul 5.

Department of Human Genetics, Saarland University, Homburg/Saar, Germany.

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http://dx.doi.org/10.1055/s-0037-1604083DOI Listing
January 2018

RegulatorTrail: a web service for the identification of key transcriptional regulators.

Nucleic Acids Res 2017 07;45(W1):W146-W153

Center for Bioinformatics, Saarland Informatics Campus, Saarland University, 66123 Saarbrücken, Germany.

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http://dx.doi.org/10.1093/nar/gkx350DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5570139PMC
July 2017

Exploring ncRNAs in Alzheimer's disease by miRMaster.

Oncotarget 2017 Jan;8(3):3771-3772

Department of Clinical Bioinformatics, Saarland University, Saarbrücken, Germany.

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http://dx.doi.org/10.18632/oncotarget.14054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354793PMC
January 2017

miRNAs in Ancient Tissue Specimens of the Tyrolean Iceman.

Mol Biol Evol 2017 04;34(4):793-801

Medical Faculty, Institute of Human Genetics, Saarland University, Homburg, Germany.

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http://dx.doi.org/10.1093/molbev/msw291DOI Listing
April 2017

The miRNome of Alzheimer's disease: consistent downregulation of the miR-132/212 cluster.

Neurobiol Aging 2017 02 3;50:167.e1-167.e10. Epub 2016 Oct 3.

Department of Psychiatry and Psychotherapy, Neurobiological Laboratory, Saarland University, Homburg, Germany; Department of Psychiatry and Psychotherapy, Saarland University Hospital, Homburg, Germany.

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http://dx.doi.org/10.1016/j.neurobiolaging.2016.09.019DOI Listing
February 2017

Distribution of microRNA biomarker candidates in solid tissues and body fluids.

RNA Biol 2016 Nov 29;13(11):1084-1088. Epub 2016 Sep 29.

a Chair for Clinical Bioinformatics, Saarland University , Germany.

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http://dx.doi.org/10.1080/15476286.2016.1234658DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5100342PMC
November 2016

miRPathDB: a new dictionary on microRNAs and target pathways.

Nucleic Acids Res 2017 01 13;45(D1):D90-D96. Epub 2016 Oct 13.

Chair for Clinical Bioinformatics, Saarland Informatics Campus, Saarland University, D-66123 Saarbruecken, Germany

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http://dx.doi.org/10.1093/nar/gkw926DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5210630PMC
January 2017

miRNAs and sports: tracking training status and potentially confounding diagnoses.

J Transl Med 2016 07 26;14(1):219. Epub 2016 Jul 26.

Chair for Clinical Bioinformatics, Medical Department, Saarland University, Building E2.1, 66125, Saarbrücken, Germany.

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http://dx.doi.org/10.1186/s12967-016-0974-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4960671PMC
July 2016

Specific miRNA Disease Biomarkers in Blood, Serum and Plasma: Challenges and Prospects.

Mol Diagn Ther 2016 12;20(6):509-518

Chair for Clinical Bioinformatics, Saarland University, University Hospital Building E2.1, 66123, Saarbrücken, Germany.

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http://dx.doi.org/10.1007/s40291-016-0221-4DOI Listing
December 2016

BALL-SNPgp-from genetic variants toward computational diagnostics.

Bioinformatics 2016 06 15;32(12):1888-90. Epub 2016 Feb 15.

Chair for Clinical Bioinformatics, Saarland University, Saarbrücken 66123, Germany.

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http://dx.doi.org/10.1093/bioinformatics/btw084DOI Listing
June 2016

miEAA: microRNA enrichment analysis and annotation.

Nucleic Acids Res 2016 07 29;44(W1):W110-6. Epub 2016 Apr 29.

Chair for Clinical Bioinformatics, Saarland University, Building E 2.1, 66123 Saarbrücken, Germany.

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http://dx.doi.org/10.1093/nar/gkw345DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4987907PMC
July 2016

Syntaxin 8 is required for efficient lytic granule trafficking in cytotoxic T lymphocytes.

Biochim Biophys Acta 2016 Jul 17;1863(7 Pt A):1653-64. Epub 2016 Apr 17.

Biophysics, Center for Integrative Physiology and Molecular Medicine, School of Medicine, Saarland University, Building 48, 66421 Homburg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.bbamcr.2016.04.014DOI Listing
July 2016

MiRTargetLink--miRNAs, Genes and Interaction Networks.

Int J Mol Sci 2016 Apr 14;17(4):564. Epub 2016 Apr 14.

Chair for Clinical Bioinformatics, Saarland University, Saarbrücken D-66041, Germany.

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http://dx.doi.org/10.3390/ijms17040564DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4849020PMC
April 2016

Combining miRNA and mRNA Expression Profiles in Wilms Tumor Subtypes.

Int J Mol Sci 2016 Mar 30;17(4):475. Epub 2016 Mar 30.

Department of Human Genetics, Saarland University, 66421 Homburg/Saar, Germany.

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http://dx.doi.org/10.3390/ijms17040475DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4848931PMC
March 2016

Human alveolar epithelial cells expressing tight junctions to model the air-blood barrier.

ALTEX 2016 17;33(3):251-60. Epub 2016 Mar 17.

Drug Delivery (DDEL), Helmholtz-Institute for Pharmaceutical Research Saarland (HIPS), Saarbrücken, Germany.

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http://dx.doi.org/10.14573/altex.1511131DOI Listing
January 2017

Distribution of miRNA expression across human tissues.

Nucleic Acids Res 2016 05 25;44(8):3865-77. Epub 2016 Feb 25.

Chair for Clinical Bioinformatics, Saarland University, Saarbruecken, Germany

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http://dx.doi.org/10.1093/nar/gkw116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4856985PMC
May 2016

Differential blood-based diagnosis between benign prostatic hyperplasia and prostate cancer: miRNA as source for biomarkers independent of PSA level, Gleason score, or TNM status.

Tumour Biol 2016 Aug 29;37(8):10177-85. Epub 2016 Jan 29.

Institute of Human Genetics, Saarland University, Human Genetics, Building 60, 66421, Homburg, Germany.

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http://dx.doi.org/10.1007/s13277-016-4883-7DOI Listing
August 2016

EDISON-WMW: Exact Dynamic Programing Solution of the Wilcoxon-Mann-Whitney Test.

Genomics Proteomics Bioinformatics 2016 Feb 29;14(1):55-61. Epub 2016 Jan 29.

Chair for Clinical Bioinformatics, Medical Faculty, Saarland University, Saarbrücken 66123, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.gpb.2015.11.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4792850PMC
February 2016

Gene amplification during myogenic differentiation.

Oncotarget 2016 Feb;7(6):6864-77

Department of Human Genetics, Saarland University, 66421 Homburg/Saar, Germany.

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http://www.oncotarget.com/fulltext/6845
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http://dx.doi.org/10.18632/oncotarget.6845DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872754PMC
February 2016

Bias in High-Throughput Analysis of miRNAs and Implications for Biomarker Studies.

Anal Chem 2016 Feb 27;88(4):2088-95. Epub 2016 Jan 27.

Chair for Clinical Bioinformatics, Saarland University , 66123 Saarbrücken, Germany.

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http://dx.doi.org/10.1021/acs.analchem.5b03376DOI Listing
February 2016

Can circulating miRNAs live up to the promise of being minimal invasive biomarkers in clinical settings?

Wiley Interdiscip Rev RNA 2016 Mar-Apr;7(2):148-56. Epub 2015 Dec 15.

Institute of Human Genetics, Saarland University, University Hospital, Homburg, Germany.

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http://dx.doi.org/10.1002/wrna.1320DOI Listing
December 2016