Eckard Wimmer

Eckard Wimmer

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Eckard Wimmer

Publications by authors named "Eckard Wimmer"

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Optimization of the Codon Pair Usage of Human Respiratory Syncytial Virus Paradoxically Resulted in Reduced Viral Replication and Reduced Immunogenicity.

J Virol 2020 Jan 6;94(2). Epub 2020 Jan 6.

Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1128/JVI.01296-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6955273PMC
January 2020

Extensive genomic recoding by codon-pair deoptimization selective for mammals is a flexible tool to generate attenuated vaccine candidates for dengue virus 2.

Virology 2019 Nov 5;537:237-245. Epub 2019 Sep 5.

Department of Molecular Genetics and Microbiology, Stony Brook University School of Medicine, Stony Brook, NY, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00426822193026
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http://dx.doi.org/10.1016/j.virol.2019.09.003DOI Listing
November 2019

Dengue and Zika Virus 5' Untranslated Regions Harbor Internal Ribosomal Entry Site Functions.

mBio 2019 04 9;10(2). Epub 2019 Apr 9.

Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, New York, USA

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http://dx.doi.org/10.1128/mBio.00459-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456755PMC
April 2019

Extensive recoding of dengue virus type 2 specifically reduces replication in primate cells without gain-of-function in Aedes aegypti mosquitoes.

PLoS One 2018 7;13(9):e0198303. Epub 2018 Sep 7.

Stony Brook University, Department of Molecular Genetics and Microbiology, Stony Brook University School of Medicine, Stony Brook, New York, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0198303PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6128446PMC
February 2019

Limits of variation, specific infectivity, and genome packaging of massively recoded poliovirus genomes.

Proc Natl Acad Sci U S A 2017 10 25;114(41):E8731-E8740. Epub 2017 Sep 25.

Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, NY, 11794;

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http://dx.doi.org/10.1073/pnas.1714385114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5642728PMC
October 2017

Genetic stability of genome-scale deoptimized RNA virus vaccine candidates under selective pressure.

Proc Natl Acad Sci U S A 2017 01 3;114(3):E386-E395. Epub 2017 Jan 3.

RNA Viruses Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892.

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http://dx.doi.org/10.1073/pnas.1619242114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5255620PMC
January 2017

A Single Amino Acid Substitution in Poliovirus Nonstructural Protein 2CATPase Causes Conditional Defects in Encapsidation and Uncoating.

J Virol 2016 07 24;90(14):6174-6186. Epub 2016 Jun 24.

Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, New York, USA.

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http://dx.doi.org/10.1128/JVI.02877-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4936127PMC
July 2016

Evaluation of the attenuation, immunogenicity, and efficacy of a live virus vaccine generated by codon-pair bias de-optimization of the 2009 pandemic H1N1 influenza virus, in ferrets.

Vaccine 2016 Jan 2;34(4):563-570. Epub 2015 Dec 2.

Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, United States. Electronic address:

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http://dx.doi.org/10.1016/j.vaccine.2015.11.054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4713281PMC
January 2016

Eradicating polio: A balancing act.

Science 2016 Jan;351(6271):348

Department of Molecular Genetics and Microbiology, School of Medicine, Stony Brook University, Stony Brook, NY 11794, USA.

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http://dx.doi.org/10.1126/science.351.6271.348-bDOI Listing
January 2016

Brunenders: a partially attenuated historic poliovirus type I vaccine strain.

J Gen Virol 2015 Sep 26;96(9):2614-2622. Epub 2015 May 26.

Janssen Infectious Diseases and Vaccines, Leiden, The Netherlands.

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http://dx.doi.org/10.1099/vir.0.000197DOI Listing
September 2015

Initiation of protein-primed picornavirus RNA synthesis.

Virus Res 2015 Aug 12;206:12-26. Epub 2015 Jan 12.

Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, NY 11790, United States.

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http://dx.doi.org/10.1016/j.virusres.2014.12.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4476921PMC
August 2015

Reply to Simmonds et al.: Codon pair and dinucleotide bias have not been functionally distinguished.

Proc Natl Acad Sci U S A 2015 Jul 12;112(28):E3635-6. Epub 2015 Jun 12.

Department of Molecular Genetics and Microbiology, Stony Brook University School of Medicine, Stony Brook, NY 11794

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http://dx.doi.org/10.1073/pnas.1507710112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4507201PMC
July 2015

Attenuation of human respiratory syncytial virus by genome-scale codon-pair deoptimization.

Proc Natl Acad Sci U S A 2014 Sep 25;111(36):13169-74. Epub 2014 Aug 25.

RNA Viruses Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892; and.

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http://dx.doi.org/10.1073/pnas.1411290111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4246931PMC
September 2014

Picornavirus morphogenesis.

Microbiol Mol Biol Rev 2014 Sep;78(3):418-37

Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, New York, USA

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http://dx.doi.org/10.1128/MMBR.00012-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4187686PMC
September 2014

Poliomyelitis in transgenic mice expressing CD155 under the control of the Tage4 promoter after oral and parenteral poliovirus inoculation.

J Gen Virol 2014 Aug 30;95(Pt 8):1668-1676. Epub 2014 Apr 30.

Department of Molecular Genetics and Microbiology, School of Medicine, Stony Brook University, Stony Brook, NY 11794, USA.

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http://dx.doi.org/10.1099/vir.0.064535-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4103066PMC
August 2014

A C-terminal, cysteine-rich site in poliovirus 2C(ATPase) is required for morphogenesis.

J Gen Virol 2014 Jun 20;95(Pt 6):1255-1265. Epub 2014 Feb 20.

Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, NY 11794, USA.

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http://dx.doi.org/10.1099/vir.0.062497-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4027037PMC
June 2014

An interaction between glutathione and the capsid is required for the morphogenesis of C-cluster enteroviruses.

PLoS Pathog 2014 Apr 10;10(4):e1004052. Epub 2014 Apr 10.

Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, New York, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1004052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3983063PMC
April 2014

Binding of glutathione to enterovirus capsids is essential for virion morphogenesis.

PLoS Pathog 2014 Apr 10;10(4):e1004039. Epub 2014 Apr 10.

Department of Microbiology and Immunology, Rega Institute for Medical Research, University of Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1371/journal.ppat.1004039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3983060PMC
April 2014

Polypyrimidine tract binding protein-1 (PTB1) is a determinant of the tissue and host tropism of a human rhinovirus/poliovirus chimera PV1(RIPO).

PLoS One 2013 4;8(4):e60791. Epub 2013 Apr 4.

Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, New York, New York, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0060791PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3617181PMC
November 2013

Deliberate reduction of hemagglutinin and neuraminidase expression of influenza virus leads to an ultraprotective live vaccine in mice.

Proc Natl Acad Sci U S A 2013 Jun 20;110(23):9481-6. Epub 2013 May 20.

Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, NY 11794, USA.

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http://dx.doi.org/10.1073/pnas.1307473110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3677463PMC
June 2013

Profile of Eckard Wimmer. Interview by Sujata Gupta.

Authors:
Eckard Wimmer

Proc Natl Acad Sci U S A 2013 Feb 31;110(6):1973-5. Epub 2012 Dec 31.

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http://dx.doi.org/10.1073/pnas.1221558110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3568298PMC
February 2013

Alanine scanning of poliovirus 2CATPase reveals new genetic evidence that capsid protein/2CATPase interactions are essential for morphogenesis.

J Virol 2012 Sep 3;86(18):9964-75. Epub 2012 Jul 3.

Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, New York, USA.

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http://dx.doi.org/10.1128/JVI.00914-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3446611PMC
September 2012

Identification of two functionally redundant RNA elements in the coding sequence of poliovirus using computer-generated design.

Proc Natl Acad Sci U S A 2012 Sep 10;109(36):14301-7. Epub 2012 Aug 10.

Department of Molecular Genetics and Microbiology and Computer Science, Stony Brook University, Stony Brook, NY 11794, USA.

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http://dx.doi.org/10.1073/pnas.1211484109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3437848PMC
September 2012

Evolution of poliovirus defective interfering particles expressing Gaussia luciferase.

J Virol 2012 Feb 7;86(4):1999-2010. Epub 2011 Dec 7.

Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, New York, USA.

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http://dx.doi.org/10.1128/JVI.05871-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3302396PMC
February 2012

Synthetic poliovirus and other designer viruses: what have we learned from them?

Annu Rev Microbiol 2011 ;65:583-609

Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, New York 11790, USA.

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http://dx.doi.org/10.1146/annurev-micro-090110-102957DOI Listing
January 2012

A host-specific, temperature-sensitive translation defect determines the attenuation phenotype of a human rhinovirus/poliovirus chimera, PV1(RIPO).

J Virol 2011 Jul 11;85(14):7225-35. Epub 2011 May 11.

Department of Molecular Genetics and Microbiology, Life Sciences Building, Stony Brook University, Stony Brook, NY 11794-5222, USA.

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http://dx.doi.org/10.1128/JVI.01804-09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3126568PMC
July 2011

Introducing recombinant picornaviral genomes into cells.

Cold Spring Harb Protoc 2011 Jun 1;2011(6):657-63. Epub 2011 Jun 1.

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http://dx.doi.org/10.1101/pdb.prot5626DOI Listing
June 2011

Oncolytic poliovirus therapy and immunization with poliovirus-infected cell lysate induces potent antitumor immunity against neuroblastoma in vivo.

Int J Oncol 2011 Jan;38(1):81-7

Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, NY 11790, USA.

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January 2011

Direct interaction between two viral proteins, the nonstructural protein 2C and the capsid protein VP3, is required for enterovirus morphogenesis.

PLoS Pathog 2010 Aug 26;6(8):e1001066. Epub 2010 Aug 26.

Department of Molecular Genetics and Microbiology, School of Medicine, Stony Brook University, Stony Brook, New York, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1001066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2928791PMC
August 2010

Live attenuated influenza virus vaccines by computer-aided rational design.

Nat Biotechnol 2010 Jul 13;28(7):723-6. Epub 2010 Jun 13.

Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, New York, USA.

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http://dx.doi.org/10.1038/nbt.1636DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2902615PMC
July 2010

Cis-acting RNA elements in human and animal plus-strand RNA viruses.

Biochim Biophys Acta 2009 Sep-Oct;1789(9-10):495-517. Epub 2009 Sep 23.

Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, NY 11790, USA.

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http://dx.doi.org/10.1016/j.bbagrm.2009.09.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2783963PMC
January 2010

Inhibition of hepatitis C virus IRES-mediated translation by oligonucleotides.

Virus Res 2009 Dec 29;146(1-2):29-35. Epub 2009 Aug 29.

Division of Gastroenterology, Department of Medicine, College of Medicine-Jacksonville, University of Florida, Jacksonville, FL 32206, United States.

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http://dx.doi.org/10.1016/j.virusres.2009.08.008DOI Listing
December 2009

Synthetic viruses: a new opportunity to understand and prevent viral disease.

Nat Biotechnol 2009 Dec;27(12):1163-72

Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, New York, USA.

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http://dx.doi.org/10.1038/nbt.1593DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2819212PMC
December 2009

HIV- 1 protease inhibits Cap- and poly(A)-dependent translation upon eIF4GI and PABP cleavage.

PLoS One 2009 Nov 24;4(11):e7997. Epub 2009 Nov 24.

Centro de Biología Molecular Severo Ochoa (CSIC-UAM), Nicolás Cabrera 1, Universidad Autónoma de Madrid, Cantoblanco, Spain.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0007997PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2776998PMC
November 2009

Putting synthesis into biology: a viral view of genetic engineering through de novo gene and genome synthesis.

Chem Biol 2009 Mar;16(3):337-47

Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, NY 11794-5222, USA.

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http://dx.doi.org/10.1016/j.chembiol.2009.03.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2728443PMC
March 2009

Crystal structure of CD155 and electron microscopic studies of its complexes with polioviruses.

Proc Natl Acad Sci U S A 2008 Nov 14;105(47):18284-9. Epub 2008 Nov 14.

Department of Biological Sciences, Purdue University, 915 West State Street, West Lafayette, IN 47907-2054, USA.

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http://dx.doi.org/10.1073/pnas.0807848105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2587566PMC
November 2008

Characterization of the New World monkey homologues of human poliovirus receptor CD155.

J Virol 2008 Jul 14;82(14):7167-79. Epub 2008 May 14.

Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, NY 11794-5222, USA.

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http://dx.doi.org/10.1128/JVI.02664-07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2446954PMC
July 2008

Virus attenuation by genome-scale changes in codon pair bias.

Science 2008 Jun;320(5884):1784-7

Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, NY 11794, USA.

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http://dx.doi.org/10.1126/science.1155761DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2754401PMC
June 2008

Growth phenotypes and biosafety profiles in poliovirus-receptor transgenic mice of recombinant oncolytic polio/human rhinoviruses.

J Med Virol 2008 Feb;80(2):352-9

Department of Molecular Genetics and Microbiology, School of Medicine, Stony Brook University, Stony Brook, NY 11794-5222, USA.

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http://dx.doi.org/10.1002/jmv.21063DOI Listing
February 2008

Vaccination against polio should not be stopped.

Nat Rev Microbiol 2007 Dec;5(12):952-8

Konstantin Chumakov is at the Center for Biologics Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike, Rockville, Maryland 20852, USA.

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http://www.nature.com/articles/nrmicro1769
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http://dx.doi.org/10.1038/nrmicro1769DOI Listing
December 2007

Complete protein linkage map between the P2 and P3 non-structural proteins of poliovirus.

J Gen Virol 2007 Aug;88(Pt 8):2259-67

Department of Molecular Genetics and Microbiology, School of Medicine, Stony Brook University, Stony Brook, NY 11794, USA.

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http://dx.doi.org/10.1099/vir.0.82795-0DOI Listing
August 2007

Tyrosine 3 of poliovirus terminal peptide VPg(3B) has an essential function in RNA replication in the context of its precursor protein, 3AB.

J Virol 2007 Jun 14;81(11):5669-84. Epub 2007 Mar 14.

Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, NY 11794, USA.

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http://dx.doi.org/10.1128/JVI.02350-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1900252PMC
June 2007

Membrane topography of the hydrophobic anchor sequence of poliovirus 3A and 3AB proteins and the functional effect of 3A/3AB membrane association upon RNA replication.

Biochemistry 2007 May 7;46(17):5185-99. Epub 2007 Apr 7.

Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, New York 11794-5222, USA.

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http://dx.doi.org/10.1021/bi6024758DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2519882PMC
May 2007

Evidence for emergence of diverse polioviruses from C-cluster coxsackie A viruses and implications for global poliovirus eradication.

Proc Natl Acad Sci U S A 2007 May 21;104(22):9457-62. Epub 2007 May 21.

Department of Molecular Genetics and Microbiology, School of Medicine, Stony Brook University, Stony Brook, NY 11794-5222, USA.

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http://www.pnas.org/content/104/22/9457.full.pdf
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http://www.pnas.org/cgi/doi/10.1073/pnas.0700451104
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http://dx.doi.org/10.1073/pnas.0700451104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1874223PMC
May 2007

Oncolytic treatment and cure of neuroblastoma by a novel attenuated poliovirus in a novel poliovirus-susceptible animal model.

Cancer Res 2007 Mar;67(6):2857-64

Department of Molecular Genetics and Microbiology, School of Medicine, Stony Brook University, Stony Brook, New York 11794-5222, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-06-3713DOI Listing
March 2007

The C-terminal hydrophobic domain of hepatitis C virus RNA polymerase NS5B can be replaced with a heterologous domain of poliovirus protein 3A.

J Virol 2006 Nov 13;80(22):11343-54. Epub 2006 Sep 13.

Department of Molecular Genetics and Microbiology, School of Medicine, Stony Brook University, Stony Brook, NY 11794, USA.

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http://dx.doi.org/10.1128/JVI.02072-05DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1642141PMC
November 2006

Reduction of the rate of poliovirus protein synthesis through large-scale codon deoptimization causes attenuation of viral virulence by lowering specific infectivity.

J Virol 2006 Oct;80(19):9687-96

Department of Molecular Genetics and Microbiology, Life Sciences Building, Stony Brook University, Stony Brook, NY 11794-5222, USA.

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http://dx.doi.org/10.1128/JVI.00738-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1617239PMC
October 2006

The test-tube synthesis of a chemical called poliovirus. The simple synthesis of a virus has far-reaching societal implications.

Authors:
Eckard Wimmer

EMBO Rep 2006 Jul;7 Spec No:S3-9

Department of Molecular Genetics and Microbiology, School of Medicine, Stony Brook University, Stony Brook, NY, USA.

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http://dx.doi.org/10.1038/sj.embor.7400728DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1490301PMC
July 2006

Pyrite-induced hydroxyl radical formation and its effect on nucleic acids.

Geochem Trans 2006 Apr 4;7. Epub 2006 Apr 4.

Department of Geosciences, Stony Brook University, Stony Brook, NY 11794, USA.

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http://dx.doi.org/10.1186/1467-4866-7-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1523326PMC
April 2006

Mutation of a single conserved nucleotide between the cloverleaf and internal ribosome entry site attenuates poliovirus neurovirulence.

J Virol 2005 Nov;79(22):14235-43

Department of Molecular Genetics and Microbiology, School of Medicine, Stony Brook University, Life Sciences Bldg., Stony Brook, NY 11794-5222, USA.

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http://dx.doi.org/10.1128/JVI.79.22.14235-14243.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1280220PMC
November 2005

Stimulation of poliovirus RNA synthesis and virus maturation in a HeLa cell-free in vitro translation-RNA replication system by viral protein 3CDpro.

Virol J 2005 Nov 21;2:86. Epub 2005 Nov 21.

Department of Molecular Genetics and Microbiology, School of Medicine, Stony Brook University, Stony Brook, NY 11790, USA.

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http://dx.doi.org/10.1186/1743-422X-2-86DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1315353PMC
November 2005

Poliovirus and poliomyelitis: a tale of guts, brains, and an accidental event.

Virus Res 2005 Aug;111(2):175-93

Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, NY 11794, USA.

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http://dx.doi.org/10.1016/j.virusres.2005.04.008DOI Listing
August 2005

The crystal structure of coxsackievirus A21 and its interaction with ICAM-1.

Structure 2005 Jul;13(7):1019-33

Department of Biological Sciences, Purdue University, 915 West State Street, West Lafayette, IN 47907, USA.

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http://dx.doi.org/10.1016/j.str.2005.04.011DOI Listing
July 2005

Stimulation of poliovirus synthesis in a HeLa cell-free in vitro translation-RNA replication system by viral protein 3CDpro.

J Virol 2005 May;79(10):6358-67

Department of Molecular Genetics and Microbiology, School of Medicine, Stony Brook University, Stony Brook, NY 11790, USA.

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http://dx.doi.org/10.1128/JVI.79.10.6358-6367.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1091690PMC
May 2005

Replication of a novel subgenomic HCV genotype 1a replicon expressing a puromycin resistance gene in Huh-7 cells.

Virology 2005 Mar;333(1):41-53

Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, NY 11790, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S004268220400872
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http://dx.doi.org/10.1016/j.virol.2004.12.031DOI Listing
March 2005

cis-acting RNA signals in the NS5B C-terminal coding sequence of the hepatitis C virus genome.

J Virol 2004 Oct;78(20):10865-77

Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, NY 11794, USA.

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http://dx.doi.org/10.1128/JVI.78.20.10865-10877.2004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC521798PMC
October 2004

Identification of cellular proteins enhancing activities of internal ribosomal entry sites by competition with oligodeoxynucleotides.

Nucleic Acids Res 2004 23;32(4):1308-17. Epub 2004 Feb 23.

Department of Life Science, Division of Molecular and Life Sciences, Pohang University of Science and Technology, San 31, Hyoja-Dong, Pohang, Kyungbuk 790-784, Korea.

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http://dx.doi.org/10.1093/nar/gkh300DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC390288PMC
June 2004

The double-stranded RNA-activated protein kinase mediates viral-induced encephalitis.

Virology 2003 Dec;317(2):263-74

Howard Hughes Medical Institute, University of Michigan, Ann Arbor, MI 48109, USA.

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http://dx.doi.org/10.1016/j.virol.2003.08.010DOI Listing
December 2003

A "slide-back" mechanism for the initiation of protein-primed RNA synthesis by the RNA polymerase of poliovirus.

J Biol Chem 2003 Nov 22;278(45):43951-60. Epub 2003 Aug 22.

Department of Molecular Genetics and Microbiology, School of Medicine, Stony Brook University, Stony Brook, New York 11790, USA.

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http://dx.doi.org/10.1074/jbc.M307441200DOI Listing
November 2003

Recruitment of nectin-3 to cell-cell junctions through trans-heterophilic interaction with CD155, a vitronectin and poliovirus receptor that localizes to alpha(v)beta3 integrin-containing membrane microdomains.

J Biol Chem 2003 Aug 19;278(33):31251-60. Epub 2003 May 19.

Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, New York 11794, USA.

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http://dx.doi.org/10.1074/jbc.M304166200DOI Listing
August 2003

Analysis of the cloverleaf element in a human rhinovirus type 14/poliovirus chimera: correlation of subdomain D structure, ternary protein complex formation and virus replication.

J Gen Virol 2003 Aug;84(Pt 8):2203-2216

Department of Molecular Genetics and Microbiology, School of Medicine, Stony Brook University, Stony Brook, NY 11794-5222, USA.

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http://dx.doi.org/10.1099/vir.0.19013-0DOI Listing
August 2003

Immunofluorescence analysis of poliovirus receptor expression in Peyer's patches of humans, primates, and CD155 transgenic mice: implications for poliovirus infection.

J Infect Dis 2002 Sep 9;186(5):585-92. Epub 2002 Aug 9.

Department of Epidemiology and Public Health, School of Medicine, Yale University, New Haven, Connecticut, USA.

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http://dx.doi.org/10.1086/342682DOI Listing
September 2002

Chemical synthesis of poliovirus cDNA: generation of infectious virus in the absence of natural template.

Science 2002 Aug 11;297(5583):1016-8. Epub 2002 Jul 11.

Department of Molecular Genetics and Microbiology, School of Medicine, State University of New York at Stony Brook, Stony Brook, NY 11794-5222, USA.

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http://dx.doi.org/10.1126/science.1072266DOI Listing
August 2002

Vaccines should be kept even if polio is wiped out.

Nature 2002 Aug;418(6901):915

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http://dx.doi.org/10.1038/418915aDOI Listing
August 2002

Expression of the human poliovirus receptor/CD155 gene is activated by sonic hedgehog.

J Biol Chem 2002 Jul 30;277(28):25697-702. Epub 2002 Apr 30.

Department of Molecular Genetics and Microbiology, School of Medicine, State University of New York at Stony Brook, 11794, USA.

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http://dx.doi.org/10.1074/jbc.M201378200DOI Listing
July 2002

Nectin couples cell-cell adhesion and the actin scaffold at heterotypic testicular junctions.

Curr Biol 2002 Jul;12(13):1145-50

Department of Molecular Biology and Biochemistry, Osaka University Graduate School of Medicine/Faculty of Medicine, 2-2 Yamada-oka, Japan.

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http://dx.doi.org/10.1016/s0960-9822(02)00922-3DOI Listing
July 2002

Interaction of the poliovirus receptor CD155 with the dynein light chain Tctex-1 and its implication for poliovirus pathogenesis.

J Biol Chem 2002 Mar 21;277(10):7897-904. Epub 2001 Dec 21.

Department of Molecular Genetics and Microbiology, State University of New York, Stony Brook, New York 11794, USA.

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http://dx.doi.org/10.1074/jbc.M111937200DOI Listing
March 2002

Synchrotron radiation-induced X-ray emission to identify metal ions in preparations of purified protein.

Biotechniques 2002 Jan;32(1):134-6, 138, 140-1

State University of New York at Stony Brook, USA.

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http://dx.doi.org/10.2144/02321rr02DOI Listing
January 2002

The C-terminal residues of poliovirus proteinase 2A(pro) are critical for viral RNA replication but not for cis- or trans-proteolytic cleavage.

J Gen Virol 2001 Feb;82(Pt 2):397-408

Department of Molecular Genetics and Microbiology, School of Medicine, State University of New York at Stony Brook, Stony Brook, NY 11794, USA1.

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http://dx.doi.org/10.1099/0022-1317-82-2-397DOI Listing
February 2001

Cell-free synthesis of poliovirus: 14S subunits are the key intermediates in the encapsidation of poliovirus RNA.

J Gen Virol 2000 Nov;81(Pt 11):2751-2754

Department of Microbiology and Hygiene, Vrije Universiteit Brussel, Laarbeeklaan 103, B-1090 Brussels, Belgium1.

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http://dx.doi.org/10.1099/0022-1317-81-11-2751DOI Listing
November 2000