Earl R Kern

Earl R Kern

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Earl R Kern

Publications by authors named "Earl R Kern"

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Orthopoxvirus targets for the development of new antiviral agents.

Antiviral Res 2012 May 8;94(2):111-25. Epub 2012 Mar 8.

Department of Pediatrics, The University of Alabama at Birmingham, Birmingham, AL 35233-1711, United States.

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http://dx.doi.org/10.1016/j.antiviral.2012.02.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3773844PMC
May 2012

Cyclopropavir inhibits the normal function of the human cytomegalovirus UL97 kinase.

Antimicrob Agents Chemother 2011 Oct 25;55(10):4682-91. Epub 2011 Jul 25.

University of Alabama at Birmingham, Department of Pediatrics, 128 Children's Harbor Building, 1600 6th Avenue South, Birmingham, AL 35233-1711, USA.

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http://dx.doi.org/10.1128/AAC.00571-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3186952PMC
October 2011

CMX001 potentiates the efficacy of acyclovir in herpes simplex virus infections.

Antimicrob Agents Chemother 2011 Oct 25;55(10):4728-34. Epub 2011 Jul 25.

University of Alabama at Birmingham, Department of Pediatrics, 128 Children's Harbor Building, 1600 6th Avenue South, Birmingham, AL 35233-1711, USA.

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http://aac.asm.org/content/55/10/4728.full.pdf
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http://aac.asm.org/cgi/doi/10.1128/AAC.00545-11
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http://dx.doi.org/10.1128/AAC.00545-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3186990PMC
October 2011

The search for new therapies for human cytomegalovirus infections.

Virus Res 2011 May 21;157(2):212-21. Epub 2010 Nov 21.

Department of Pediatrics, University of Alabama School of Medicine, Birmingham, AL 35233-1711, USA.

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http://dx.doi.org/10.1016/j.virusres.2010.11.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3068221PMC
May 2011

Benzimidazole analogs inhibit human herpesvirus 6.

Antimicrob Agents Chemother 2011 May 7;55(5):2442-5. Epub 2011 Feb 7.

University of Alabama School of Medicine, 1600 6th Avenue South, 128 Children's Harbor Building, Birmingham, AL 35233, USA.

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http://dx.doi.org/10.1128/AAC.01523-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3088228PMC
May 2011

Treatment of Vaccinia and Cowpox Virus Infections in Mice with CMX001 and ST-246.

Viruses 2010 12 13;2(12):2681-95. Epub 2010 Dec 13.

Department of Pediatrics, School of Medicine, The University of Alabama, 170 Children's Harbor Building, 1600 6th Avenue South, Birmingham, Birmingham, AL 35233, USA; E-Mail:

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http://dx.doi.org/10.3390/v2122681DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3185598PMC
December 2010

Efficacy of CMX001 against herpes simplex virus infections in mice and correlations with drug distribution studies.

J Infect Dis 2010 Nov 5;202(10):1492-9. Epub 2010 Oct 5.

The University of Alabama at Birmingham School of Medicine, Birmingham, Alabama 35233-1711, USA.

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http://dx.doi.org/10.1086/656717DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2957530PMC
November 2010

Antiviral Activity of 4'-thioIDU and Thymidine Analogs against Orthopoxviruses.

Viruses 2010 Sep 16;2(9):1968-83. Epub 2010 Sep 16.

Department of Pediatrics, University of Alabama School of Medicine, CHB 128, 1600 6th Ave S, Birmingham AL 35233-1711, USA; E-Mail:

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http://dx.doi.org/10.3390/v2091968DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3185742PMC
September 2010

Inhibition of herpesvirus replication by 5-substituted 4'-thiopyrimidine nucleosides.

Antimicrob Agents Chemother 2009 Dec 21;53(12):5251-8. Epub 2009 Sep 21.

Department of Pediatrics, University of Alabama School of Medicine, Birmingham, AL 35233, USA.

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http://dx.doi.org/10.1128/AAC.00417-09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2786333PMC
December 2009

Virucidal activity of polysaccharide extracts from four algal species against herpes simplex virus.

Antiviral Res 2009 Sep 1;83(3):282-9. Epub 2009 Jul 1.

Department of Pediatrics, University of Alabama School of Medicine, Birmingham, AL 35233 USA.

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http://dx.doi.org/10.1016/j.antiviral.2009.06.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2730659PMC
September 2009

Activities of certain 5-substituted 4'-thiopyrimidine nucleosides against orthopoxvirus infections.

Antimicrob Agents Chemother 2009 Feb 24;53(2):572-9. Epub 2008 Nov 24.

Department of Pediatrics, University of Alabama School of Medicine, Birmingham, 35233, USA.

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http://dx.doi.org/10.1128/AAC.01257-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2630668PMC
February 2009

Inhibition of herpesvirus replication by hexadecyloxypropyl esters of purine- and pyrimidine-based phosphonomethoxyethyl nucleoside phosphonates.

Antimicrob Agents Chemother 2008 Dec 13;52(12):4326-30. Epub 2008 Oct 13.

Department of Pediatrics, University of Alabama School of Medicine, 128 Children's Harbor Building, 1600 6th Ave. South, Birmingham, AL 35233, USA.

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http://aac.asm.org/cgi/doi/10.1128/AAC.00918-08
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http://dx.doi.org/10.1128/AAC.00918-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2592848PMC
December 2008

Amphipathic DNA polymers exhibit antiherpetic activity in vitro and in vivo.

Antimicrob Agents Chemother 2008 Aug 27;52(8):2727-33. Epub 2008 May 27.

Division of Infectious Diseases, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave., Cincinnati, OH 45229, USA.

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http://dx.doi.org/10.1128/AAC.00279-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2493138PMC
August 2008

Synergistic efficacy of the combination of ST-246 with CMX001 against orthopoxviruses.

Antimicrob Agents Chemother 2007 Nov 27;51(11):4118-24. Epub 2007 Aug 27.

Department of Pediatrics, The University of Alabama at Birmingham, Birmingham, AL 35233-1711, USA.

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http://aac.asm.org/content/early/2007/08/27/AAC.00762-07.ful
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http://aac.asm.org/cgi/doi/10.1128/AAC.00762-07
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http://dx.doi.org/10.1128/AAC.00762-07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2151443PMC
November 2007

Effect of oral treatment with hexadecyloxypropyl-[(S)-9-(3-hydroxy-2- phosphonylmethoxypropyl)adenine] [(S)-HPMPA] or octadecyloxyethyl-(S)-HPMPA on cowpox or vaccinia virus infections in mice.

Antimicrob Agents Chemother 2007 Nov 10;51(11):3940-7. Epub 2007 Sep 10.

Department of Pediatrics, The University of Alabama at Birmingham, School of Medicine, CHB 128, 1600 6th Avenue South, Birmingham, AL 35233, USA.

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http://dx.doi.org/10.1128/AAC.00184-07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2151427PMC
November 2007

A rapid DNA hybridization assay for the evaluation of antiviral compounds against Epstein-Barr virus.

J Virol Methods 2007 Sep 30;144(1-2):86-90. Epub 2007 May 30.

Department of Pediatrics, University of Alabama School of Medicine, Birmingham, AL 35233, USA.

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http://dx.doi.org/10.1016/j.jviromet.2007.04.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1995440PMC
September 2007

Fluoroanalogues of anti-cytomegalovirus agent cyclopropavir: synthesis and antiviral activity of (E)- and (Z)-9-{[2,2-bis(hydroxymethyl)-3-fluorocyclopropylidene]methyl}-adenines and guanines.

Nucleosides Nucleotides Nucleic Acids 2007 ;26(3):231-43

Developmental Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan 48201-1379, USA.

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http://dx.doi.org/10.1080/15257770701257210DOI Listing
June 2007

Efficacy of delayed treatment with ST-246 given orally against systemic orthopoxvirus infections in mice.

Antimicrob Agents Chemother 2007 Feb 20;51(2):689-95. Epub 2006 Nov 20.

University of Alabama at Birmingham, School of Medicine, Department of Pediatrics, 128 Children's Harbor Building, 1600 6th Avenue South, Birmingham, AL 35233-1711, USA.

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http://dx.doi.org/10.1128/AAC.00879-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1797744PMC
February 2007

Antiviral activities of novel 5-phosphono-pent-2-en-1-yl nucleosides and their alkoxyalkyl phosphonoesters.

Antimicrob Agents Chemother 2007 Feb 27;51(2):611-5. Epub 2006 Nov 27.

Department of Medicine (0676), University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0676, USA.

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http://aac.asm.org/cgi/doi/10.1128/AAC.00444-06
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http://dx.doi.org/10.1128/AAC.00444-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1797766PMC
February 2007

Synthesis and antiviral evaluation of alkoxyalkyl esters of phosphonopropoxymethyl-guanine and phosphonopropoxymethyl-diaminopurine.

Antivir Chem Chemother 2006 ;17(2):89-95

Department of Medicine, Division of Infectious Disease, University of California, San Diego, CA, USA.

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http://dx.doi.org/10.1177/095632020601700204DOI Listing
November 2006

9-{[3-fluoro-2-(hydroxymethyl)cyclopropylidene]methyl}adenines and -guanines. Synthesis and antiviral activity of all stereoisomers1.

J Med Chem 2006 Oct;49(20):6120-8

Department of Chemistry, Developmental Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan 48201-1379, USA.

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http://dx.doi.org/10.1021/jm0607404DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2562564PMC
October 2006

Assembling a smallpox biodefense by interrogating 5-substituted pyrimidine nucleoside chemical space.

Antiviral Res 2006 Sep 19;71(2-3):201-5. Epub 2006 May 19.

Department of Chemistry and Biochemistry, Northern Arizona University, Flagstaff, AZ 86011, USA.

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http://dx.doi.org/10.1016/j.antiviral.2006.04.015DOI Listing
September 2006

Pivotal role of animal models in the development of new therapies for cytomegalovirus infections.

Authors:
Earl R Kern

Antiviral Res 2006 Sep 19;71(2-3):164-71. Epub 2006 Jun 19.

The University of Alabama at Birmingham, Department of Pediatrics, CHB 128, 1600 6th Avenue South, Birmingham, AL 35233, United States.

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http://dx.doi.org/10.1016/j.antiviral.2006.05.018DOI Listing
September 2006

Distinct thymidine kinases encoded by cowpox virus and herpes simplex virus contribute significantly to the differential antiviral activity of nucleoside analogs.

Antiviral Res 2006 Aug 28;71(1):1-6. Epub 2006 Feb 28.

University of Alabama School of Medicine, Department of Pediatrics, Birmingham, 35233, USA.

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http://dx.doi.org/10.1016/j.antiviral.2006.01.013DOI Listing
August 2006

In vitro and in vivo evaluation of isatin-beta-thiosemicarbazone and marboran against vaccinia and cowpox virus infections.

Antiviral Res 2006 Aug 29;71(1):24-30. Epub 2006 Mar 29.

University of Alabama School of Medicine, Birmingham, USA.

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http://dx.doi.org/10.1016/j.antiviral.2006.02.010DOI Listing
August 2006

Toward orthopoxvirus countermeasures: a novel heteromorphic nucleoside of unusual structure.

J Med Chem 2006 Jul;49(14):4052-4

Department of Chemistry and Biochemistry, Northern Arizona University, Flagstaff, 86011, USA.

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http://dx.doi.org/10.1021/jm060404nDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4298854PMC
July 2006

A pyrimidine-pyrazolone nucleoside chimera with potent in vitro anti-orthopoxvirus activity.

Bioorg Med Chem Lett 2006 Jun 5;16(12):3224-8. Epub 2006 Apr 5.

Department of Chemistry and Biochemistry, Northern Arizona University, Flagstaff, AZ 86011, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S0960894X0600336
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http://dx.doi.org/10.1016/j.bmcl.2006.03.043DOI Listing
June 2006

5-(Dimethoxymethyl)-2'-deoxyuridine: a novel gem diether nucleoside with anti-orthopoxvirus activity.

J Med Chem 2006 Jun;49(11):3377-82

Department of Chemistry and Biochemistry, Northern Arizona University, Flagstaff, Arizona 86011, USA.

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http://dx.doi.org/10.1021/jm0601710DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4262926PMC
June 2006

Activity and mechanism of action of N-methanocarbathymidine against herpesvirus and orthopoxvirus infections.

Antimicrob Agents Chemother 2006 Apr;50(4):1336-41

Department of Pediatrics, University of Alabama School of Medicine, Birmingham, AL 35233, USA.

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http://dx.doi.org/10.1128/AAC.50.4.1336-1341.2006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1426929PMC
April 2006

Genetically engineered herpes simplex viruses that express IL-12 or GM-CSF as vaccine candidates.

Vaccine 2006 Mar 5;24(10):1644-52. Epub 2005 Oct 5.

Department of Pediatrics, Division of Infectious Diseases, The University of Alabama at Birmingham, CHB 118B, 1600 6th Avenue South, Birmingham, AL 35233, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S0264410X0501016
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http://dx.doi.org/10.1016/j.vaccine.2005.09.051DOI Listing
March 2006

Effect of immunization with herpes simplex virus type-1 (HSV-1) glycoprotein D (gD) plus the immune enhancer GPI-0100 on infection with HSV-1 or HSV-2.

Vaccine 2006 Mar 24;24(10):1515-22. Epub 2005 Oct 24.

University of Alabama at Birmingham, Department of Pediatrics, CHB 128, 1600 6th Avenue South, Birmingham, AL 35233-1711, USA.

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http://dx.doi.org/10.1016/j.vaccine.2005.10.017DOI Listing
March 2006

Phosphoralaninate pronucleotides of pyrimidine methylenecyclopropane analogues of nucleosides: synthesis and antiviral activity.

Nucleosides Nucleotides Nucleic Acids 2005 ;24(10-12):1763-74

Department of Chemistry, Developmental Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan 48201-1379, USA.

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http://www.tandfonline.com/doi/abs/10.1080/15257770500266867
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http://dx.doi.org/10.1080/15257770500266867DOI Listing
March 2006

Synthesis and antiviral evaluation of alkoxyalkyl derivatives of 9-(S)-(3-hydroxy-2-phosphonomethoxypropyl)adenine against cytomegalovirus and orthopoxviruses.

J Med Chem 2006 Mar;49(6):2010-5

Department of Medicine, VA San Diego Healthcare System and the University of California, San Diego, La Jolla, California 92093-0676, USA.

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http://dx.doi.org/10.1021/jm050473mDOI Listing
March 2006

Human cytomegalovirus UL27 is not required for viral replication in human tissue implanted in SCID mice.

Virol J 2006 Mar 29;3:18. Epub 2006 Mar 29.

Department of Pediatrics, University of Alabama School of Medicine, Birmingham, AL, USA.

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http://dx.doi.org/10.1186/1743-422X-3-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1448171PMC
March 2006

Synthesis, antiviral, and antitumor activity of 2-substituted purine methylenecyclopropane analogues of nucleosides.

Bioorg Med Chem 2006 Feb 18;14(4):1247-54. Epub 2005 Oct 18.

Developmental Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201-1379, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S096808960500931
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http://dx.doi.org/10.1016/j.bmc.2005.09.052DOI Listing
February 2006

Synthesis of cyclopentenyl carbocyclic nucleosides as potential antiviral agents against orthopoxviruses and SARS.

J Med Chem 2006 Feb;49(3):1140-8

The University of Georgia College of Pharmacy, Athens, GA 30602, USA.

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http://dx.doi.org/10.1021/jm0509750DOI Listing
February 2006

Synthesis, physicochemical properties and antiviral activities of ester prodrugs of ganciclovir.

Int J Pharm 2005 Nov 19;305(1-2):75-89. Epub 2005 Oct 19.

Division of Pharmaceutical Sciences, School of Pharmacy, University of Missouri-Kansas City, 5005 Rockhill Road, Kansas City, MO 64110-2499, USA.

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http://dx.doi.org/10.1016/j.ijpharm.2005.08.024DOI Listing
November 2005

The 4',4'-difluoro analog of 5'-noraristeromycin: a new structural prototype for possible antiviral drug development toward orthopoxvirus and cytomegalovirus.

Bioorg Med Chem 2005 Jul;13(14):4443-9

Department of Chemistry and Biochemistry, Auburn University, Auburn, AL 36849, USA.

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http://dx.doi.org/10.1016/j.bmc.2005.04.044DOI Listing
July 2005

Recurrent antiviral-resistant genital herpes in an immunocompetent patient.

J Infect Dis 2005 Jul 27;192(1):156-61. Epub 2005 May 27.

Department of Medicine, University of Utah, Salt Lake City, Utah 84132, USA.

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http://dx.doi.org/10.1086/430612DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4265802PMC
July 2005

Combinatorial optimization of isatin-beta-thiosemicarbazones as anti-poxvirus agents.

J Med Chem 2005 Apr;48(8):3045-50

Department of Chemistry, Levine Science Research Center, Box 90317, Duke University, Durham, North Carolina 27708-0317, USA.

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http://dx.doi.org/10.1021/jm049147hDOI Listing
April 2005

In vitro activity and mechanism of action of methylenecyclopropane analogs of nucleosides against herpesvirus replication.

Antimicrob Agents Chemother 2005 Mar;49(3):1039-45

The University of Alabama at Birmingham, Department of Pediatrics, 128 Children's Harbor Building, 1600 6th Ave. South, Birmingham, AL 35233, USA.

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http://aac.asm.org/cgi/doi/10.1128/AAC.49.3.1039-1045.2005
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http://dx.doi.org/10.1128/AAC.49.3.1039-1045.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC549243PMC
March 2005

Orthopoxvirus targets for the development of antiviral therapies.

Curr Drug Targets Infect Disord 2005 Mar;5(1):17-28

University of Alabama School of Medicine, Department of Pediatrics, 1600 6th Avenue South, Birmingham, AL 35233, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4264105PMC
March 2005

Ether lipid-ester prodrugs of acyclic nucleoside phosphonates: activity against adenovirus replication in vitro.

J Infect Dis 2005 Feb 29;191(3):396-9. Epub 2004 Dec 29.

University of Alabama School of Medicine, Birmingham, Alabama 35233, USA.

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http://dx.doi.org/10.1086/426831DOI Listing
February 2005

Comparison of the antiviral activities of alkoxyalkyl and alkyl esters of cidofovir against human and murine cytomegalovirus replication in vitro.

Antimicrob Agents Chemother 2005 Feb;49(2):656-62

Veterans Administration San Diego Healthcare System, Department of Medicine, University of California, San Diego, Mail Code 0676, 9500 Gilman Dr., La Jolla, CA 92093-0676, USA.

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http://aac.asm.org/cgi/doi/10.1128/AAC.49.2.656-662.2005
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http://dx.doi.org/10.1128/AAC.49.2.656-662.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC547274PMC
February 2005

Inhibition of herpesvirus replication by a series of 4-oxo-dihydroquinolines with viral polymerase activity.

Antiviral Res 2005 Feb;65(2):97-105

Department of Pediatrics, The University of Alabama School of Medicine, 128 CHB, 1600 6th Avenue South, Birmingham, AL 35233, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S016635420400242
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http://dx.doi.org/10.1016/j.antiviral.2004.10.003DOI Listing
February 2005

Nucleotides and pronucleotides of 2,2-bis(hydroxymethyl)methylenecyclopropane analogues of purine nucleosides: synthesis and antiviral activity.

J Med Chem 2005 Jan;48(1):91-9

Department of Chemistry, Developmental Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan 48201-1379, USA.

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http://dx.doi.org/10.1021/jm040149bDOI Listing
January 2005

Oral activity of a methylenecyclopropane analog, cyclopropavir, in animal models for cytomegalovirus infections.

Antimicrob Agents Chemother 2004 Dec;48(12):4745-53

University of Alabama School of Medicine, Department of Pediatrics, Division of Infectious Diseases, Birmingham, Birmingham, Alabama 35233, USA.

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http://aac.asm.org/cgi/doi/10.1128/AAC.48.12.4745-4753.2004
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http://dx.doi.org/10.1128/AAC.48.12.4745-4753.2004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC529216PMC
December 2004

(Z)- and (E)-[2-Fluoro-2-(hydroxymethyl)cyclopropylidene]methylpurines and -pyrimidines, a new class of methylenecyclopropane analogues of nucleosides: synthesis and antiviral activity.

J Med Chem 2004 Dec;47(27):6964-72

Department of Chemistry, Developmental Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201-1379, USA.

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http://dx.doi.org/10.1021/jm040093lDOI Listing
December 2004

Oral treatment of murine cytomegalovirus infections with ether lipid esters of cidofovir.

Antimicrob Agents Chemother 2004 Sep;48(9):3516-22

Department of Pediatrics, The University of Alabama at Birmingham, School of Medicine, CHB 128, 1600 6th Ave. South, Birmingham, AL 35233, USA.

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http://dx.doi.org/10.1128/AAC.48.9.3516-3522.2004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC514741PMC
September 2004

Oral activity of ether lipid ester prodrugs of cidofovir against experimental human cytomegalovirus infection.

J Infect Dis 2004 Aug 1;190(3):499-503. Epub 2004 Jul 1.

University of Alabama School of Medicine, Birmingham 35233, USA.

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http://dx.doi.org/10.1086/421912DOI Listing
August 2004

Cutaneous infections of mice with vaccinia or cowpox viruses and efficacy of cidofovir.

Antiviral Res 2004 Jul;63(1):33-40

The University of Alabama School of Medicine, Birmingham, AL, USA.

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http://dx.doi.org/10.1016/j.antiviral.2004.02.003DOI Listing
July 2004

Efficacy of ganciclovir and cidofovir against human cytomegalovirus replication in SCID mice implanted with human retinal tissue.

Antiviral Res 2004 Jul;63(1):61-4

Department of Pediatrics, University of Alabama School of Medicine, 128 CHB, 1600 6th Avenue South, Birmingham, AL 35233, USA.

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http://dx.doi.org/10.1016/j.antiviral.2004.02.002DOI Listing
July 2004

Activities of benzimidazole D- and L-ribonucleosides in animal models of cytomegalovirus infections.

Antimicrob Agents Chemother 2004 May;48(5):1749-55

Department of Pediatrics, University of Alabama School of Medicine, Birmingham, Alabama 35233, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC400580PMC
http://dx.doi.org/10.1128/aac.48.5.1749-1755.2004DOI Listing
May 2004

Oral treatment of cowpox and vaccinia virus infections in mice with ether lipid esters of cidofovir.

Antimicrob Agents Chemother 2004 Feb;48(2):404-12

The University of Alabama School of Medicine, Birmingham, Alabama, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC321539PMC
http://dx.doi.org/10.1128/aac.48.2.404-412.2004DOI Listing
February 2004

Synthesis and antiviral activity of (Z)- and (E)-2,2-[bis(hydroxymethyl)cyclopropylidene]methylpurines and -pyrimidines: second-generation methylenecyclopropane analogues of nucleosides.

J Med Chem 2004 Jan;47(3):566-75

Department of Chemistry, Developmental Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan 48201-1379, USA.

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http://dx.doi.org/10.1021/jm030316sDOI Listing
January 2004

Synthesis and biological activity of 2-aminopurine methylenecyclopropane analogues of nucleosides.

Nucleosides Nucleotides Nucleic Acids 2003 May-Aug;22(5-8):813-5

Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan 48201-1379, USA.

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http://dx.doi.org/10.1081/NCN-120022660DOI Listing
December 2003

Efficacy of methylenecyclopropane analogs of nucleosides against herpesvirus replication in vitro.

Nucleosides Nucleotides Nucleic Acids 2003 Dec;22(12):2105-19

The University of Alabama School of Medicine, Birmingham, Alabama, USA.

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December 2003

Efficacy of multiple- or single-dose cidofovir against vaccinia and cowpox virus infections in mice.

Antimicrob Agents Chemother 2003 Oct;47(10):3275-80

The University of Alabama School of Medicine, Birmingham, Alabama 35233, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC201130PMC
http://dx.doi.org/10.1128/aac.47.10.3275-3280.2003DOI Listing
October 2003

Structure-activity relationships of (S,Z)-2-aminopurine methylenecyclopropane analogues of nucleosides. Variation of purine-6 substituents and activity against herpesviruses and hepatitis B virus.

J Med Chem 2003 Apr;46(8):1531-7

Department of Chemistry, Developmental Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan 48201-1379, USA.

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http://dx.doi.org/10.1021/jm0205245DOI Listing
April 2003

Determination of antiviral efficacy against lymphotropic herpesviruses utilizing flow cytometry.

Antiviral Res 2003 Apr;58(2):149-57

Department of Pediatrics, University of Alabama, BBRB 309, 845 19th Street South, Birmingham, AL 35294-2170, USA.

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http://dx.doi.org/10.1016/s0166-3542(02)00210-3DOI Listing
April 2003

Synthesis and biological activities of 2-functionalized purine nucleosides.

Nucleosides Nucleotides Nucleic Acids 2003 Feb;22(2):115-27

Department of Pharmaceutical and Biomedical Sciences, University of Georgia, Athens, Georgia 30602, USA.

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http://dx.doi.org/10.1081/NCN-120019498DOI Listing
February 2003

Synthesis and biological activity of 2-aminopurine methylenecyclopropane analogues of nucleosides.

Nucleosides Nucleotides Nucleic Acids 2003 Feb;22(2):135-44

Developmental Chemotherapy Program, Department of Chemistry, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan 48201-1379, USA.

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http://www.tandfonline.com/doi/abs/10.1081/NCN-120019502
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http://dx.doi.org/10.1081/NCN-120019502DOI Listing
February 2003

In vitro activity of potential anti-poxvirus agents.

Authors:
Earl R Kern

Antiviral Res 2003 Jan;57(1-2):35-40

Department of Pediatrics, University of Alabama School of Medicine, BBRB 309, 845 19th Street South, Birmingham, AL 35294-2170, USA.

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http://dx.doi.org/10.1016/s0166-3542(02)00198-5DOI Listing
January 2003

Tryptophanyl phosphoramidates as prodrugs of synadenol and its E-isomer: synthesis and biological activity.

Bioorg Med Chem Lett 2002 Sep;12(17):2467-70

Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201-1379, USA.

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http://dx.doi.org/10.1016/s0960-894x(02)00423-7DOI Listing
September 2002

Alkoxyalkyl esters of cidofovir and cyclic cidofovir exhibit multiple-log enhancement of antiviral activity against cytomegalovirus and herpesvirus replication in vitro.

Antimicrob Agents Chemother 2002 Aug;46(8):2381-6

Department of Medicine, Veterans Affairs Medical Center, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0676, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC127379PMC
http://dx.doi.org/10.1128/aac.46.8.2381-2386.2002DOI Listing
August 2002

Synthesis of methylenecyclobutane analogues of nucleosides with axial chirality and their phosphoralaninates: a new pronucleotide effective against Epstein-Barr virus.

Antivir Chem Chemother 2002 Jul;13(4):251-62

Department of Chemistry, Developmental Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Mich, USA.

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http://journals.sagepub.com/doi/10.1177/095632020201300406
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http://dx.doi.org/10.1177/095632020201300406DOI Listing
July 2002

The enantiomers of carbocyclic 5'-norguanosine: activity towards Epstein-Barr virus.

Bioorg Med Chem 2002 Apr;10(4):883-6

Department of Chemistry, Auburn University, Auburn, AL 36849-5312, USA.

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http://dx.doi.org/10.1016/s0968-0896(01)00344-3DOI Listing
April 2002