Earl G Brown

Earl G Brown

UNVERIFIED PROFILE

Are you Earl G Brown?   Register this Author

Register author
Earl G Brown

Earl G Brown

Publications by authors named "Earl G Brown"

Are you Earl G Brown?   Register this Author

49Publications

1001Reads

38Profile Views

Influenza A virus cap-snatches host RNAs based on their abundance early after infection.

Virology 2017 09 22;509:167-177. Epub 2017 Jun 22.

Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada K1H 8M5. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.virol.2017.06.020DOI Listing
September 2017

Residues F103 and M106 within the influenza A virus NS1 CPSF4-binding region regulate interferon-stimulated gene translation initiation.

Virology 2017 08 26;508:170-179. Epub 2017 May 26.

Department of Immunology, University of Toronto, 1 King's College Circle, Toronto, Ontario, Canada M5S 1A8; Toronto General Hospital Research Institute, University Health Network, 67 College Street, Room 424, Toronto, Ontario, Canada M5G 2M1. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.virol.2017.05.009DOI Listing
August 2017

A Conserved Residue, Tyrosine (Y) 84, in H5N1 Influenza A Virus NS1 Regulates IFN Signaling Responses to Enhance Viral Infection.

Viruses 2017 05 12;9(5). Epub 2017 May 12.

Toronto General Hospital Research Institute, University Health Network, 67 College Street, Toronto, ON M5G 2M1, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/v9050107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5454420PMC
May 2017

Modelling idiopathic Parkinson disease as a complex illness can inform incidence rate in healthy adults: the P EDIGT score.

Eur J Neurosci 2017 01 27;45(1):175-191. Epub 2016 Dec 27.

Neuroscience Program, Ottawa Hospital Research Institute, 451 Smyth Road, RGH #1414, Ottawa, ON, K1H 8M5, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ejn.13476DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5324667PMC
January 2017

Influenza Virus Targets Class I MHC-Educated NK Cells for Immunoevasion.

PLoS Pathog 2016 Feb 29;12(2):e1005446. Epub 2016 Feb 29.

Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, Ontario, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.ppat.1005446DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4771720PMC
February 2016

Identification of adaptive mutations in the influenza A virus non-structural 1 gene that increase cytoplasmic localization and differentially regulate host gene expression.

PLoS One 2013 31;8(12):e84673. Epub 2013 Dec 31.

Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada ; Emerging Pathogens Research Centre, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0084673PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3877356PMC
September 2014

Deep sequencing reveals the eight facets of the influenza A/HongKong/1/1968 (H3N2) virus cap-snatching process.

Sci Rep 2014 Aug 26;4:6181. Epub 2014 Aug 26.

Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, K1H 8M5, Canada.

View Article

Download full-text PDF

Source
http://www.nature.com/articles/srep06181
Publisher Site
http://dx.doi.org/10.1038/srep06181DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4143772PMC
August 2014

Universal anti-neuraminidase antibody inhibiting all influenza A subtypes.

Antiviral Res 2013 Nov 30;100(2):567-74. Epub 2013 Sep 30.

Centre for Vaccine Evaluation, Biologics and Genetic Therapies Directorate, HPFB, Health Canada, Ottawa, ON, Canada; Department of Biochemistry, Microbiology and Immunology and Emerging Pathogens Research Centre, University of Ottawa, Ottawa, ON, Canada.

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S01663542130026
Publisher Site
http://dx.doi.org/10.1016/j.antiviral.2013.09.018DOI Listing
November 2013

A monoclonal antibody targeting a highly conserved epitope in influenza B neuraminidase provides protection against drug resistant strains.

Biochem Biophys Res Commun 2013 Nov 16;441(1):226-9. Epub 2013 Oct 16.

Centre for Vaccine Evaluation, Biologics and Genetic Therapies Directorate, HPFB, Health Canada, Ottawa, ON, Canada; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbrc.2013.10.041DOI Listing
November 2013

The universal epitope of influenza A viral neuraminidase fundamentally contributes to enzyme activity and viral replication.

J Biol Chem 2013 Jun 3;288(25):18283-9. Epub 2013 May 3.

Centre for Vaccine Evaluation, Biologics and Genetic Therapies Directorate, Health Products and Food Branch, Health Canada, Ottawa, Ontario K1A 0K9, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M113.468884DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3689970PMC
June 2013

Generation and characterization of a new panel of broadly reactive anti-NS1 mAbs for detection of influenza A virus.

J Gen Virol 2013 Mar 5;94(Pt 3):593-605. Epub 2012 Dec 5.

Manitoba Institute of Child Health, Room 513, John Buhler Research Centre, 715 McDermot Avenue, Winnipeg, MB R3E 3P4, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1099/vir.0.046649-0DOI Listing
March 2013

Respiratory infection of mice with mammalian reoviruses causes systemic infection with age and strain dependent pneumonia and encephalitis.

Virol J 2013 Mar 1;10:67. Epub 2013 Mar 1.

Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, 451 Smyth Rd, Ottawa, Ontario K1H 8M5, Canada.

View Article

Download full-text PDF

Source
http://virologyj.biomedcentral.com/articles/10.1186/1743-422
Publisher Site
http://dx.doi.org/10.1186/1743-422X-10-67DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3605257PMC
March 2013

Mouse-adapted H9N2 influenza A virus PB2 protein M147L and E627K mutations are critical for high virulence.

PLoS One 2012 10;7(7):e40752. Epub 2012 Jul 10.

Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, Beijing, China.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0040752PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3393695PMC
January 2013

Adaptive mutation in influenza A virus non-structural gene is linked to host switching and induces a novel protein by alternative splicing.

Emerg Microbes Infect 2012 Nov 21;1(11):e42. Epub 2012 Nov 21.

Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa , Ottawa, Ontario K1H 8M5, Canada ; Emerging Pathogens Research Centre, Faculty of Medicine, University of Ottawa , Ottawa, Ontario K1H 8M5, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/emi.2012.38DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3630925PMC
November 2012

Hepatitis C virus: the role of molecular mimicry in response to interferon treatment.

J Med Virol 2012 Oct;84(10):1571-85

Department of Epidemiology and Surveillance, Canadian Blood Services, Ottawa, Ontario, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jmv.23361DOI Listing
October 2012

Pathogenicity of H3N8 influenza viruses isolated from domestic ducks in chickens with or without Escherichia coli coinfections.

Avian Dis 2012 Sep;56(3):597-600

Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1637/9984-110911-ResNote.1DOI Listing
September 2012

Low-pathogenic avian influenza virus A/turkey/Ontario/6213/1966 (H5N1) is the progenitor of highly pathogenic A/turkey/Ontario/7732/1966 (H5N9).

J Gen Virol 2012 Aug 16;93(Pt 8):1649-1657. Epub 2012 May 16.

Canadian Institutes of Health Research (CIHR) Canadian Influenza Pathogenesis Team, University of Ottawa, 451 Smyth Rd, Ottawa, Ontario, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1099/vir.0.042895-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3541759PMC
August 2012

Multifunctional adaptive NS1 mutations are selected upon human influenza virus evolution in the mouse.

PLoS One 2012 21;7(2):e31839. Epub 2012 Feb 21.

Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0031839PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3283688PMC
June 2012

Identification of RNA helicase A as a cellular factor that interacts with influenza A virus NS1 protein and its role in the virus life cycle.

J Virol 2012 Feb 14;86(4):1942-54. Epub 2011 Dec 14.

Vaccine and Infectious Disease Organization, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.

View Article

Download full-text PDF

Source
http://jvi.asm.org/cgi/doi/10.1128/JVI.06362-11
Publisher Site
http://dx.doi.org/10.1128/JVI.06362-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3302408PMC
February 2012

Negative regulation of lung inflammation and immunopathology by TNF-α during acute influenza infection.

Am J Pathol 2011 Dec 14;179(6):2963-76. Epub 2011 Oct 14.

Department of Pathology and Molecular Medicine & McMaster Immunology Research Centre, McMaster University, Hamilton, Ontario, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ajpath.2011.09.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3260802PMC
December 2011

Control of pathogenic CD4 T cells and lethal immunopathology by signaling immunoadaptor DAP12 during influenza infection.

J Immunol 2011 Oct 9;187(8):4280-92. Epub 2011 Sep 9.

Department of Pathology and Molecular Medicine, McMaster Immunology Research Centre, McMaster University, Hamilton, Ontario L8S 4K1, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4049/jimmunol.1101050DOI Listing
October 2011

Influenza A virus NS1 gene mutations F103L and M106I increase replication and virulence.

Virol J 2011 Jan 12;8:13. Epub 2011 Jan 12.

Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa 451 Smyth Rd, Ottawa, Ontario K1H8M5, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/1743-422X-8-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3032709PMC
January 2011

PB2 and hemagglutinin mutations are major determinants of host range and virulence in mouse-adapted influenza A virus.

J Virol 2010 Oct 11;84(20):10606-18. Epub 2010 Aug 11.

Department of Biochemistry, Faculty of Medicine, University of Ottawa, 451 Smyth Road, Ottawa, Ontario, Canada K1H 8M5.

View Article

Download full-text PDF

Source
http://jvi.asm.org/content/84/20/10606.full.pdf
Web Search
http://jvi.asm.org/lookup/doi/10.1128/JVI.01187-10
Publisher Site
http://dx.doi.org/10.1128/JVI.01187-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2950562PMC
October 2010

Quantitative proteomic analyses of influenza virus-infected cultured human lung cells.

J Virol 2010 Oct 11;84(20):10888-906. Epub 2010 Aug 11.

Department of Medical Microbiology, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba R3E 0J6, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/JVI.00431-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2950599PMC
October 2010

Immunogenicity and protective efficacy of an elastase-dependent live attenuated swine influenza virus vaccine administered intranasally in pigs.

Vaccine 2010 Oct 12;28(43):7098-108. Epub 2010 Aug 12.

Vaccine and Infectious Disease Organization, University of Saskatchewan, 120 Veterinary Road, Saskatoon, Saskatchewan S7N 5E3, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.vaccine.2010.08.003DOI Listing
October 2010

Aurintricarboxylic acid is a potent inhibitor of influenza A and B virus neuraminidases.

PLoS One 2009 Dec 17;4(12):e8350. Epub 2009 Dec 17.

Centre for Biologics Research, Biologics and Genetic Therapies Directorate, HPFB, Health Canada, Ottawa, Ontario, Canada; Department of Microbiology, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia. [corrected].

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0008350PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2792043PMC
December 2009

Serologic evidence of prevalent avian H3 subtype influenza virus infection in chickens.

Avian Dis 2009 Jun;53(2):198-204

Laboratory of Infectious Diseases, College of Veterinary Medicine, China Agricultural University, Beijing 100193, PR China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1637/8410-071708-Reg.1DOI Listing
June 2009

Genetic analysis of H3 subtype influenza viruses isolated from domestic ducks in northern China during 2004-2005.

Virus Genes 2009 Feb 9;38(1):136-42. Epub 2008 Dec 9.

Laboratory of Infectious Diseases, College of Veterinary Medicine, China Agricultural University, Beijing, 100193, People's Republic of China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11262-008-0300-7DOI Listing
February 2009

Experimental evolution of human influenza virus H3 hemagglutinin in the mouse lung identifies adaptive regions in HA1 and HA2.

J Virol 2008 Dec 1;82(23):11599-608. Epub 2008 Oct 1.

Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.

View Article

Download full-text PDF

Source
http://jvi.asm.org/content/early/2008/10/01/JVI.01393-08.ful
Web Search
http://jvi.asm.org/cgi/doi/10.1128/JVI.01393-08
Publisher Site
http://dx.doi.org/10.1128/JVI.01393-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2583651PMC
December 2008

Simplified recombinational approach for influenza A virus reverse genetics.

J Virol Methods 2008 Jul 5;151(1):74-8. Epub 2008 May 5.

Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, 451 Smyth Road, Ottawa, Ontario, Canada K1H 8M5.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jviromet.2008.03.020DOI Listing
July 2008

Antigenic and genetic characterization of H9N2 swine influenza viruses in China.

J Gen Virol 2007 Jul;88(Pt 7):2035-41

Laboratory of Infectious Diseases, College of Veterinary Medicine, State Key Laboratory for Agrobiotechnology, China Agricultural University, Beijing 100094, PR China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1099/vir.0.82783-0DOI Listing
July 2007

Cigarette smoke impacts immune inflammatory responses to influenza in mice.

Am J Respir Crit Care Med 2006 Dec 5;174(12):1342-51. Epub 2006 Oct 5.

Department of Pathology and Molecular Medicine, Centre for Gene Therapeutics, McMaster University, Hamilton, ON, L8N 3Z5 Canada.

View Article

Download full-text PDF

Source
http://www.atsjournals.org/doi/abs/10.1164/rccm.200604-561OC
Publisher Site
http://dx.doi.org/10.1164/rccm.200604-561OCDOI Listing
December 2006

Influenza virus receptor specificity and cell tropism in mouse and human airway epithelial cells.

J Virol 2006 Aug;80(15):7469-80

Department of Internal Medicine, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/JVI.02677-05DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1563738PMC
August 2006

Immunoglobulin mimicry by Hepatitis C Virus envelope protein E2.

Virology 2005 Feb;332(2):538-49

Canadian Blood Services, 1800 Alta Vista Drive, Ottawa, Ontario, Canada K1G 4J5.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.virol.2004.11.041DOI Listing
February 2005

Comparative analysis of the SARS coronavirus genome: a good start to a long journey.

Lancet 2003 May;361(9371):1756-7

Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ontario, K1H 8M5, Ottawa, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/S0140-6736(03)13444-7DOI Listing
May 2003

Mammalian reovirus core protein micro 2 initiates at the first start codon and is acetylated.

Rapid Commun Mass Spectrom 2002 ;16(24):2317-24

Department of Medical Microbiology, University of Manitoba, Winnipeg, MB Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/rcm.866DOI Listing
February 2003

Aggregation of influenza virus ribonucleocapsids at low pH.

Virus Res 2002 May;85(2):141-9

Department of Biochemistry, Microbiology, and Immunology, Faculty of Medicine, University of Ottawa, 451 Smyth Road, Ottawa, ON, Canada K1H 8M5.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/s0168-1702(02)00028-xDOI Listing
May 2002