Publications by authors named "E Ture"

9 Publications

Treatment of sialorrhea with botulinum toxin A injection in children.

Niger J Clin Pract 2021 Jun;24(6):847-852

Department of Pediatric Pulmonology, Meram Medical Faculty, Necmettin Erbakan University, Konya, Turkey.

Aims: We aimed to evaluate the effectivity and safety of botulinum toxin A (BT-A) to reduce sialorrhea in children with hypersalivation due to neurological diseases.

Methods: Patients who had a complaint of severe sialorrhea were included in the study. Drooling severity of the patients was evaluated using the classification of Thomas-Stonell and Greenberg. The frequency of aspiration before and after the procedure was recorded. The 24-hour saliva amount and mean duration of two consecutive aspirations were recorded. BT-A was injected into the bilateral parotid and submandibular glands by a otorhinolaryngologist under the guidance of ultrasound guidance (USG).

Results: When patients' mean drooling severity scores, drooling frequency scores, mean duration of two consecutive aspirations, and amount of saliva collected before and after procedure were compared, a statistical significance was observed. One-year hospital records before after and injection were examined and it was observed that after BT-A injection, hospital visits were statistically significantly low (P = 0.017).

Conclusion: BT-A injection into salivary glands is well tolerated, is minimally invasive, has low complication rates and should be performed into both parotid and submandibular glands under USG. Although there is still no consensus on the ideal dose and frequency of injections, it is thought that a dose of 1U/kg/gland can be used with safety in pediatric age groups and the dimensions of the salivary glands and quantitative measurements of the amount of saliva should be utilized. Larger studies involving more patients are required in order to constitute a standard injection protocol.
View Article and Find Full Text PDF

Download full-text PDF

Source Listing
June 2021

Early Kidney Injury in Immunoglobulin A Vasculitis: Role of Renal Biomarkers.

Pediatr Int 2021 Jan 10. Epub 2021 Jan 10.

Department of Pediatric Nephrology, Meram Medical Faculty, Necmettin Erbakan University, Turkey.

Background: We aimed to determine whether urine Kidney Injury Molecule-1 (KIM-1) and Neutrophil Gelatinase Associated Lipocalin (NGAL) can be used as early noninvasive biomarkers of kidney injury in Immunoglobulin A vasculitis.

Methods: Patients who were diagnosed with Immunoglobulin A vasculitis were included in the study. Urine samples were collected for determination of urine KIM-1and NGAL levels. The control group was comprised of age-matched healthy children.

Results: 61 patients who diagnosed with Immunoglobulin A vasculitis were included in the study. 37.7% of these patients were determined to have renal involvement. Median KIM-1 was found to be statistically significantly higher in the patient group (69.59 pg/ml) compared to the control group (40.84 pg/ml) (p= 0.001). Median NGAL was determined to be statistically significantly higher in the patient group (59.87 ng/ml) compared to the control group (44.87 ng/ml) (p=0.013). In 23.6% of the patients without renal involvement at admission were found to develop renal involvement within following six months. When median KIM-1 and NGAL at admission of these patients were compared with the control group, they were determined to be statistically significantly higher (p= 0.001, p= 0.003).

Conclusions: The fact that our patients with late-term nephropathy had no hematuria and/or proteinuria and that KIM-1and NGAL levels, however, were determined to be high indicates that these biomarkers might be potentially reliable, noninvasive and early determinants of kidney injury.
View Article and Find Full Text PDF

Download full-text PDF

Source Listing
January 2021

Point-of-care lung ultrasound findings in the pediatric emergency clinic during the COVID-19 pandemic.

J Clin Ultrasound 2021 Feb 13;49(2):85-90. Epub 2020 Nov 13.

Department of Pediatrics, Bursa City Hospital, Bursa, Turkey.

Purpose: To describe our experience concerning lung ultrasound (LUS) in the pediatric emergency clinic, and to investigate the diagnostic value of LUS in coronavirus disease-2019 (COVID-19).

Methods: Patients aged under 18 admitted to the pediatric emergency clinic with suspicion of COVID-19, who underwent point-of-care LUS and from whom COVID-19 reverse transcription polymerase chain reaction (RT-PCR) samples were collected, were included in the study.

Results: Point-of-care LUS was performed on 74 patients in the emergency room. LUS findings were more sensitive than chest X-ray in the early stages of the disease and in mild cases. Involvement was observed at LUS despite RT-PCR being negative in some symptomatic patients with a COVID-19 contact history.

Conclusions: We think that LUS can be beneficial in terms of identifying patients with lung involvement and staging their severity in this new disease in pediatric emergency clinics. The procedure is noninvasive, rapid, reproducible, and low cost, involving simple sterilization. Based on the current literature and our own practical experience, we think that increased use of point-of-care LUS can protect patients from unnecessary radiation and treatment delays during the COVID-19 pandemic.
View Article and Find Full Text PDF

Download full-text PDF

Source Listing
February 2021

[Evaluation of Patients Diagnosed with COVID-19 in Terms of Risk Factors].

Mikrobiyol Bul 2020 Oct;54(4):575-582

Health Sciences University, Samsun Training and Research Hospital, Clinic of Infectious Diseases and Clinical Microbiology, Samsun, Turkey.

Coronaviruses are RNA viruses that can cause disease in the upper and lower respiratory tract in humans and animals. Lately, a new coronavirus causing pneumonia cases was detected in Wuhan, China in December 2019. Soon after, the name of the virus was identified as the "severe acute respiratory syndrome coronavirus-2", and the World Health Organization named the disease coronavirus disease-2019 (COVID-19). In our country, the first cases began to appear in the second week of March. In this study, we aimed to investigate the demographic characteristics and risk factors of patients with the diagnosis of COVID-19. A total of 100 patients (53 female and 47 male) were included in our study. The patients included in the study were randomly selected from the registration system and their information was evaluated retrospectively. The mean age of the patients was 54.42 (Age range= 20-90). When the risk factors for catching the disease were evaluated; it was determined that there was at least one risk factor in 46 patients; 30 patients had close contact with the COVID-19 patient in the social environment (30%) and 16 patients had a travel history outside the city in the last 14 days (16%). The most common symptoms in our patients were; cough (93%), fever (42%), dyspnea (22%), weakness (8%), sore throat (7%), diarrhea (6%), headache (5%) and sputum (2%). The most common comorbid conditions in our patients were detected as hypertension (42%), diabetes mellitus (DM) (21%), congestive heart failure (10%), allergic asthma (7%), chronic obstructive pulmonary disease (6%), rheumatoid arthritis (3%), coronary artery disease (2%), solid organ tumour (2%), depression (1%) and epilepsy (1%). The mean age of our 15 patients who were monitored in intensive care unit was 65 y (± 11.46), the mean age of 85 patients followed in the service was 52.55 (± 16.35) and this difference was statistically significant (p= 0.006). When these two groups were compared in terms of comorbid diseases, the presence of DM was 40% higher (n= 6) in intensive care patients, and this difference was statistically significant (p= 0.05). In addition, the majority [11 patients (73%)] of the patients hospitalized in the intensive care unit were male (p= 0.03). When smoking was evaluated as a risk factor for serious illness, 4 of 11 patients (26%) in intensive care unit had a smoking history, while none of the patients who have died due to COVID-19 had a smoking history. These findings suggested to us that smoking does not increase the severity of COVID-19 disease. As a result, knowledge about the disease should be increased rapidly by sharing the studies on risk factors, transmission routes and clinical features of COVID-19 infection, which affects the whole world.
View Article and Find Full Text PDF

Download full-text PDF

Source Listing
October 2020

The Epidemiological and Clinical Characteristics of 81 Children with COVID-19 in a Pandemic Hospital in Turkey: an Observational Cohort Study.

J Korean Med Sci 2020 Jun 29;35(25):e236. Epub 2020 Jun 29.

Department of Clinical Microbiology, Bursa City Hospital, Bursa, Turkey.

Background: Coronavirus disease-2019 (COVID-19) pandemic has affected millions of people throughout the world since December 2019. However, there is a limited amount of data about pediatric patients infected with the disease agent, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

Methods: The epidemiological, laboratory, radiological, and treatment features of the pediatric patients who were positive for SARS-CoV-2 based on the reverse-transcription polymerase chain reaction (RT-PCR) test, were investigated retrospectively.

Results: The median age of 81 children included in the study was 9.50 years (0-17.75 years). The most frequent symptoms at the time of admission were fever (58%), cough (52%), and fatigue or myalgia (19%). The abnormal laboratory findings in these cases were decreased lymphocytes (2.5%, n = 2), leucopenia (5%, n = 4), and increased lactate dehydrogenase (17.2%, n = 14), C-reactive protein (16%, n = 13), procalcitonin (3.7%, n = 3), and D-dimer (12.3%, n = 10). Three (4%) patients had consolidation in chest computed tomography, and three (4%) had ground-glass opacities. None of the patients needed intensive care except for the newborns. The median time to turn SARS-CoV-2 negative in the RT-PCR test was 5 (3-10) days. The median length of hospital stay was 5 (4-10) days. The time to turn SARS-CoV-2 negative in the RT-PCR test and the length of hospital stay were significantly longer for those aged five years or younger than others ( = 0.037, = 0.01).

Conclusion: Compared to adults, COVID-19 is milder and more distinctive in children. As a result, more conservative approaches might be preferred in children for the diagnostic, clinical, and even therapeutic applications.
View Article and Find Full Text PDF

Download full-text PDF

Source Listing
June 2020