Publications by authors named "E Saunders Alpaugh"

6 Publications

Peripheral Nerve Stimulation: A Review of Techniques and Clinical Efficacy.

Pain Ther 2021 Jul 31. Epub 2021 Jul 31.

Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Chronic pain is a common source of morbidity in many patient populations worldwide. There are growing concerns about the potential side effects of currently prescribed medications and a continued need for effective treatment. Related to these concerns, peripheral nerve stimulation has been regaining popularity as a potential treatment modality. Peripheral nerve stimulation components include helically coiled electrical leads, which direct an applied current to afferent neurons providing sensory innervation to the painful area. In theory, the applied current to the peripheral nerve will alter the large-diameter myelinated afferent nerve fibers, which interfere with the central processing of pain signals through small-diameter afferent fibers at the level of the spinal cord. Multiple studies have shown success in the use of peripheral nerve stimulation for acute post-surgical pain for orthopedic surgery, including post total knee arthroplasty and anterior cruciate ligament surgery, and chronic knee pain. Many studies have investigated the utility of peripheral nerve stimulation for the management of chronic shoulder pain. Peripheral nerve stimulation also serves as one of the potential non-pharmacologic therapies to treat back pain along with physical therapy, application of transcutaneous electrical neurostimulation unit, radiofrequency ablation, epidural steroid injections, permanently implanted neurostimulators, and surgery. Studies regarding back pain treatment have shown that peripheral nerve stimulation led to significant improvement in all pain and quality-of-life measures and a reduction in the use of opioids. Further studies are needed as the long-term risks and benefits of peripheral nerve stimulation have not been well studied as most information available on the effectiveness of peripheral nerve stimulation is based on shorter-term improvements in chronic pain.
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http://dx.doi.org/10.1007/s40122-021-00298-1DOI Listing
July 2021

Pharmacogenomics, concepts for the future of perioperative medicine and pain management: A review.

Best Pract Res Clin Anaesthesiol 2020 Sep 22;34(3):651-662. Epub 2020 Jul 22.

Louisiana State University Health Shreveport, Department of Anesthesiology, Shreveport, LA, USA. Electronic address:

Pharmacogenomics is the study of how genetic differences between individuals affect pharmacokinetics and pharmacodynamics. These differences are apparent to clinicians when taking into account the wide range of responses to medications given in clinical practice. A review of literature involving pharmacogenomics and pain management was performed. The implementation of preoperative pharmacogenomics will allow us to better care for our patients by delivering personalized, safer medicine. This review describes the current state of pharmacogenomics as it relates to many aspects of clinical practice and how clinicians can use these tools to improve patient outcomes.
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http://dx.doi.org/10.1016/j.bpa.2020.07.004DOI Listing
September 2020

How toxic agents enter the body.

Authors:
E Alpaugh

Trans Natl Saf Congr 1971 ;18:12-4

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August 1972

How toxic agents enter the body.

Authors:
E Alpaugh

Trans Natl Saf Congr 1970 ;18:12-4

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November 1973
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