Publications by authors named "E M Craig"

570 Publications

Considerations for Developing a Reassessment Process: Report from the Canadian Real-World Evidence for Value of Cancer Drugs (CanREValue) Collaboration's Reassessment and Uptake Working Group.

Curr Oncol 2021 10 16;28(5):4174-4183. Epub 2021 Oct 16.

Temerty Faculty of Medicine, University of Toronto, 1 King's College Circle, Toronto, ON M5S 1A8, Canada.

The Canadian Real-world Evidence for Value in Cancer Drugs (CanREValue) Collaboration was established to develop a framework for generating and using real-world evidence (RWE) to inform the reassessment of cancer drugs following initial health technology assessment (HTA). The Reassessment and Uptake Working Group (RWG) is one of the five established CanREValue Working Groups. The RWG aims to develop considerations for incorporating RWE for HTA reassessment and strategies for using RWE to reassess drug funding decisions. Between February 2018 and December 2019, the RWG attended four teleconferences (with follow-up surveys) and two in-person meetings to discuss recommendations for the development of a reassessment process and potential barriers and facilitators. Modified Delphi methods were used to gather input. A draft report of recommendations (to December 2018) was shared for public consultation (December 2019 to January 2020). Initial considerations for developing a reassessment process were proposed. Specifically, reassessment can be initiated by diverse stakeholders, including decision makers from public drug plans or industry stakeholders. The reassessment process should be modelled after existing deliberation and recommendation frameworks used by HTA agencies. Proposed reassessment outcome categories include maintaining status quo, revisiting funding criteria, renegotiating price, or disinvesting. Overall, these initial considerations will serve as the basis for future advancements by the Collaboration.
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http://dx.doi.org/10.3390/curroncol28050354DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8534602PMC
October 2021

Teaching Safeguarding through Books: A Content Analysis of Child Sexual Abuse Prevention Books.

Authors:
Eleanor Craig

J Child Sex Abus 2021 Oct 20:1-19. Epub 2021 Oct 20.

University of Leeds; Leeds, UK.

Research attests that when children are given essential knowledge about Child Sexual Abuse (CSA) prevention, such as the maintenance of boundaries and personal space, the correct anatomical names for genitals, and information on how to distinguish between appropriate and inappropriate touching, children are less likely to experience sexual abuse and more likely to disclose abuse they have already encountered. CSA prevention books aim to teach children safety skills, helping to inform them on how to assess a situation and what to do if they are made to feel uncomfortable. This research analyzes 44 CSA prevention books to ascertain whether they are in line with academic recommendations as to what knowledge children should be taught in order to protect them, as much as possible, from sexual abuse. While most of the books do follow advice derived from the academic literature, only 7 books contained 70% or more of the information research determined to be essential. Despite the documented importance of teaching children anatomically correct names for genitals, this was missing in 91% of books analyzed. It is recommended, therefore, in order to ensure sufficient coverage of essential information, that multiple CSA prevention books are obtained for, and read with, children.
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http://dx.doi.org/10.1080/10538712.2021.1985672DOI Listing
October 2021

COVID-19 in Multiple Sclerosis: Clinically reported outcomes from the UK Multiple Sclerosis Register.

Mult Scler Relat Disord 2021 Oct 8;56:103317. Epub 2021 Oct 8.

Imperial College London, London, United Kingdom.

Background: In March 2020, the United Kingdom Multiple Sclerosis Register (UKMSR) established an electronic case return form, designed collaboratively by MS neurologists, to record data about COVID-19 infections in people with MS (pwMS).

Objectives: Examine how hospital admission and mortality are affected by disability, age and disease modifying treatments (DMTs) in people with Multiple Sclerosis with COVID-19.

Methods: Anonymised data were submitted by clinical teams. Regression models were tested for predictors of hospitalisation and mortality outcomes. Separate analyzes compared the first and second 'waves' of the pandemic.

Results: Univariable analysis found hospitalisation and mortality were associated with increasing age, male gender, comorbidities, severe disability, and progressive MS; severe disability showed the highest magnitude of association. Being on a DMT was associated with a small, lower risk. Multivariable analysis found only age and male gender were significant. Post hoc analysis demonstrated that factors were significant for hospitalisation but not mortality. In the second wave, hospitalisation and mortality were lower. Separate models of the first and second wave using age and gender found they had a more important role in the second wave.

Conclusions: Features associated with poor outcome in COVID-19 are similar to other populations and being on a DMT was not found to be associated with adverse outcomes, consistent with smaller studies. Once in hospital, no factors were predictive of mortality. Reassuringly, mortality appears lower in the second wave.
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http://dx.doi.org/10.1016/j.msard.2021.103317DOI Listing
October 2021

Perianal Chancres of Primary Syphilis.

JAMA Dermatol 2021 Oct 13. Epub 2021 Oct 13.

Department of Dermatology, Kaiser Permanente, San Francisco, California.

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http://dx.doi.org/10.1001/jamadermatol.2021.3763DOI Listing
October 2021

Pathway of Hsp70 interactions at the ribosome.

Nat Commun 2021 09 27;12(1):5666. Epub 2021 Sep 27.

Department of Biochemistry, University of Wisconsin-Madison, Madison, Wisconsin, 53706, USA.

In eukaryotes, an Hsp70 molecular chaperone triad assists folding of nascent chains emerging from the ribosome tunnel. In fungi, the triad consists of canonical Hsp70 Ssb, atypical Hsp70 Ssz1 and J-domain protein cochaperone Zuo1. Zuo1 binds the ribosome at the tunnel exit. Zuo1 also binds Ssz1, tethering it to the ribosome, while its J-domain stimulates Ssb's ATPase activity to drive efficient nascent chain interaction. But the function of Ssz1 and how Ssb engages at the ribosome are not well understood. Employing in vivo site-specific crosslinking, we found that Ssb(ATP) heterodimerizes with Ssz1. Ssb, in a manner consistent with the ADP conformation, also crosslinks to ribosomal proteins across the tunnel exit from Zuo1. These two modes of Hsp70 Ssb interaction at the ribosome suggest a functionally efficient interaction pathway: first, Ssb(ATP) with Ssz1, allowing optimal J-domain and nascent chain engagement; then, after ATP hydrolysis, Ssb(ADP) directly with the ribosome.
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http://dx.doi.org/10.1038/s41467-021-25930-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8476630PMC
September 2021
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