Emmanuel Darcq

Emmanuel Darcq

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Emmanuel Darcq

Emmanuel Darcq

Publications by authors named "Emmanuel Darcq"

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Current strategies toward safer mu opioid receptor drugs for pain management.

Expert Opin Ther Targets 2019 Apr 15;23(4):315-326. Epub 2019 Mar 15.

a Department of Psychiatry , McGill University, Douglas Hospital Research Center , Montréal , QC , Canada.

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http://dx.doi.org/10.1080/14728222.2019.1586882DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6497449PMC
April 2019

Biased Signaling of the Mu Opioid Receptor Revealed in Native Neurons.

iScience 2019 Apr 15;14:47-57. Epub 2019 Mar 15.

Department of Psychiatry, McGill University, Douglas Hospital Research Center, Perry Pavilion Room E-3317.1, 6875 Boulevard LaSalle, Montréal, QC H4H 1R3, Canada; Institut de Génétique et de Biologie Moléculaire et Cellulaire, 67400 Illkirch-Graffenstaden, France. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S25890042193007
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http://dx.doi.org/10.1016/j.isci.2019.03.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439305PMC
April 2019

Recommending buprenorphine for pain management.

Pain Manag 2019 01 3;9(1):13-16. Epub 2018 Dec 3.

Faculty of Medicine, Douglas Research Centre, McGill University, Montreal, Canada.

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https://www.futuremedicine.com/doi/10.2217/pmt-2018-0069
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http://dx.doi.org/10.2217/pmt-2018-0069DOI Listing
January 2019

Increased Alcohol Seeking in Mice Lacking Gpr88 Involves Dysfunctional Mesocorticolimbic Networks.

Biol Psychiatry 2018 Aug 9;84(3):202-212. Epub 2018 Feb 9.

Département de Médecine Translationnelle et Neurogénétique, Institut de Génétique et de Biologie Moléculaire et Cellulaire, Institut National de la Santé et de la Recherche Médicale U-964, Centre National de la Recherche Scientifique UMR-7104, University of Strasbourg, Illkirch-Graffenstaden, Strasbourg, France; Douglas Mental Health Institute, Department of Psychiatry, McGill University, Montreal, Quebec, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.biopsych.2018.01.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6054571PMC
August 2018

Opioid receptors: drivers to addiction?

Nat Rev Neurosci 2018 Aug;19(8):499-514

Douglas Mental Health Institute, Department of Psychiatry, McGill University, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1038/s41583-018-0028-xDOI Listing
August 2018

Discovery of a Potent, Selective, and Brain-Penetrant Small Molecule that Activates the Orphan Receptor GPR88 and Reduces Alcohol Intake.

J Med Chem 2018 Aug 30;61(15):6748-6758. Epub 2018 Jul 30.

Center for Drug Discovery , Research Triangle Institute , Research Triangle Park , North Carolina 27709 , United States.

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http://dx.doi.org/10.1021/acs.jmedchem.8b00566DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6108082PMC
August 2018

The Control of Reward Seeking.

Biol Psychiatry 2018 06;83(12):981-983

Douglas Hospital Research Center, Department of Psychiatry, Faculty of Medicine, McGill University, Montréal, Quebec, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.biopsych.2018.04.003DOI Listing
June 2018

Mapping GPR88-Venus illuminates a novel role for GPR88 in sensory processing.

Brain Struct Funct 2018 Apr 6;223(3):1275-1296. Epub 2017 Nov 6.

Department of Psychiatry, McGill University, Douglas Hospital Research Center, Perry Pavilion Room E-3317.1, 6875 boulevard LaSalle, Montreal, QC, H4H 1R3, Canada.

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http://dx.doi.org/10.1007/s00429-017-1547-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5871604PMC
April 2018

Fyn Signaling Is Compartmentalized to Dopamine D1 Receptor Expressing Neurons in the Dorsal Medial Striatum.

Front Mol Neurosci 2017 31;10:273. Epub 2017 Aug 31.

Department of Neurology, University of California San FranciscoSan Francisco, CA, United States.

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http://dx.doi.org/10.3389/fnmol.2017.00273DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5583218PMC
August 2017

Mu Opioid Receptors in Gamma-Aminobutyric Acidergic Forebrain Neurons Moderate Motivation for Heroin and Palatable Food.

Biol Psychiatry 2017 05 26;81(9):778-788. Epub 2016 Dec 26.

Institut de Génétique et de Biologie Moléculaire et Cellulaire, Centre National de la Recherche Scientifique, Institut National de la Santé et de la Recherche Médicale, Université de Strasbourg, Illkirch; Douglas Mental Health Institute, Department of Psychiatry, McGill University, Montreal, Quebec, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.biopsych.2016.12.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5386808PMC
May 2017

Translating the Habenula-From Rodents to Humans.

Biol Psychiatry 2017 02 7;81(4):296-305. Epub 2016 Jun 7.

Douglas Hospital Research Center, Department of Psychiatry, Faculty of Medicine, McGill University, Montreal, Quebec, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.biopsych.2016.06.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5143215PMC
February 2017

BOLD Imaging in Awake Wild-Type and Mu-Opioid Receptor Knock-Out Mice Reveals On-Target Activation Maps in Response to Oxycodone.

Front Neurosci 2016 3;10:471. Epub 2016 Nov 3.

Department of Psychology, Center for Translational NeuroImaging, Northeastern University Boston, MA, USA.

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http://dx.doi.org/10.3389/fnins.2016.00471DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5094148PMC
November 2016

Deletion of the mu opioid receptor gene in mice reshapes the reward-aversion connectome.

Proc Natl Acad Sci U S A 2016 10 26;113(41):11603-11608. Epub 2016 Sep 26.

Advanced Molecular Imaging Center, Medical Physics, University Medical Center Freiburg, 79106 Freiburg, Germany; Engineering Science, Computer Science, and Imaging Laboratory, Integrative Multimodal Imaging in Healthcare, UMR 7357, University of Strasbourg, CNRS, 67000 Strasbourg, France; Department of Biophysics and Nuclear Medicine, University Hospital Strasbourg, 67000 Strasbourg, France

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http://dx.doi.org/10.1073/pnas.1601640113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5068324PMC
October 2016

The Neurotrophic Factor Receptor p75 in the Rat Dorsolateral Striatum Drives Excessive Alcohol Drinking.

J Neurosci 2016 09 28;36(39):10116-27. Epub 2016 Sep 28.

Department of Neurology, University of California, San Francisco, San Francisco, California 94143,

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http://dx.doi.org/10.1523/JNEUROSCI.4597-14.2016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5039257PMC
September 2016

Striatal-enriched protein tyrosine phosphatase controls responses to aversive stimuli: implication for ethanol drinking.

PLoS One 2015 20;10(5):e0127408. Epub 2015 May 20.

Department of Neurology, University of California San Francisco, San Francisco, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0127408PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4438985PMC
April 2016

PI3K signaling in the locus coeruleus: a new molecular pathway for ADHD research.

EMBO Mol Med 2015 Jul;7(7):859-61

Department of Psychiatry, Faculty of Medicine, Douglas Hospital Research Center, McGill University, Montreal, QC, Canada.

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http://dx.doi.org/10.15252/emmm.201505266DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4520651PMC
July 2015

A novel anxiogenic role for the delta opioid receptor expressed in GABAergic forebrain neurons.

Biol Psychiatry 2015 Feb 27;77(4):404-15. Epub 2014 Aug 27.

Institut de Génétique et de Biologie Moléculaire et Cellulaire, Centre National de la Recherche Scientifique, Institut National de la Santé et de la Recherche Médicale, Université de Strasbourg, Illkirch, France.; Douglas Hospital Research Center, Department of Psychiatry, Faculty of Medicine, McGill University, Montreal, Quebec, Canada.. Electronic address:

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http://dx.doi.org/10.1016/j.biopsych.2014.07.033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4297504PMC
February 2015

Delta opioid receptors expressed in forebrain GABAergic neurons are responsible for SNC80-induced seizures.

Behav Brain Res 2015 Feb 30;278:429-34. Epub 2014 Oct 30.

Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS/INSERM/Université de Strasbourg, 1 rue Laurent Fries, 67404 Illkirch, France; Douglas Hospital Research Center, Department of Psychiatry, Faculty of Medicine, McGill University, Montreal, Quebec, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.bbr.2014.10.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4382405PMC
February 2015

Inhibition of striatal-enriched tyrosine phosphatase 61 in the dorsomedial striatum is sufficient to increased ethanol consumption.

J Neurochem 2014 Jun 27;129(6):1024-34. Epub 2014 Mar 27.

The Gallo Research Center, University of California San Francisco, San Francisco, California, USA; Department of Neurology, University of California San Francisco, San Francisco, California, USA.

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http://dx.doi.org/10.1111/jnc.12701DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055745PMC
June 2014

Protein tyrosine phosphatase α in the dorsomedial striatum promotes excessive ethanol-drinking behaviors.

J Neurosci 2013 Sep;33(36):14369-78

Gallo Center at the Department of Neurology, University of California, San Francisco, San Francisco, California 94143, USA.

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http://dx.doi.org/10.1523/JNEUROSCI.1954-13.2013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3761047PMC
September 2013

RSK2 signaling in medial habenula contributes to acute morphine analgesia.

Neuropsychopharmacology 2012 Apr 4;37(5):1288-96. Epub 2012 Jan 4.

Institut de Génétique et de Biologie Moléculaire et Cellulaire, Centre National de la Recherche Scientifique/Institut National de la Santé et de la Recherche Médicale/Université de Strasbourg, Illkirch, France.

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http://dx.doi.org/10.1038/npp.2011.316DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3306890PMC
April 2012

Protracted abstinence from distinct drugs of abuse shows regulation of a common gene network.

Addict Biol 2012 Jan 28;17(1):1-12. Epub 2011 Sep 28.

Institut de Génétique et de Biologie Moléculaire et Cellulaire, INSERM and CNRS, Illkirch-Graffenstaden, France.

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http://dx.doi.org/10.1111/j.1369-1600.2011.00365.xDOI Listing
January 2012

RSK2 signaling in brain habenula contributes to place aversion learning.

Learn Mem 2011 Sep 18;18(9):574-8. Epub 2011 Aug 18.

Institut de Génétique et de Biologie Moléculaire et Cellulaire, Centre National de la Recherche Scientifique/Institut National de la Santé et de la Recherche Médicale/Université de Strasbourg, 67404 Illkirch, France.

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http://learnmem.cshlp.org/cgi/doi/10.1101/lm.2221011
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http://dx.doi.org/10.1101/lm.2221011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3256568PMC
September 2011

Impaired emotional-like behavior and serotonergic function during protracted abstinence from chronic morphine.

Biol Psychiatry 2011 Feb 14;69(3):236-44. Epub 2010 Oct 14.

Centre National de la Recherche Scientifique/Institut National de la Santé et de la Recherche Médicale/Université de Strasbourg, Illkirch, France.

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http://dx.doi.org/10.1016/j.biopsych.2010.08.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3014999PMC
February 2011