Dyann F Wirth

Dyann F Wirth

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Dyann F Wirth

Dyann F Wirth

Publications by authors named "Dyann F Wirth"

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Detection of low-density Plasmodium falciparum infections using amplicon deep sequencing.

Malar J 2019 Jul 1;18(1):219. Epub 2019 Jul 1.

Infectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA.

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http://dx.doi.org/10.1186/s12936-019-2856-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6604269PMC
July 2019

Reply to Velavan et al.: Polymorphisms of in natural populations: Implications for functional significance.

Proc Natl Acad Sci U S A 2019 Jun;116(26):12613-12614

Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA 02115;

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http://dx.doi.org/10.1073/pnas.1907920116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6601244PMC
June 2019

The Adaptive Proline Response in P. falciparum Is Independent of PfeIK1 and eIF2α Signaling.

ACS Infect Dis 2019 04 21;5(4):515-520. Epub 2019 Feb 21.

Harvard T.H. Chan School of Public Health , 665 Huntington Avenue , Boston , Massachusetts 02115 , United States.

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http://dx.doi.org/10.1021/acsinfecdis.8b00363DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6747701PMC
April 2019

Mutations in actin-binding protein coronin confer reduced artemisinin susceptibility.

Proc Natl Acad Sci U S A 2018 12 12;115(50):12799-12804. Epub 2018 Nov 12.

Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA 02115;

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http://www.pnas.org/lookup/doi/10.1073/pnas.1812317115
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http://dx.doi.org/10.1073/pnas.1812317115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294886PMC
December 2018

Conformation-guided analogue design identifies potential antimalarial compounds through inhibition of mitochondrial respiration.

Org Biomol Chem 2018 08;16(30):5403-5406

Department of Chemistry & Biochemistry and the Warren Family Research Center for Drug Discovery, University of Notre Dame, Notre Dame, IN 46556, USA.

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http://dx.doi.org/10.1039/c8ob01257aDOI Listing
August 2018

hmmIBD: software to infer pairwise identity by descent between haploid genotypes.

Malar J 2018 May 15;17(1):196. Epub 2018 May 15.

Infectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA.

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https://malariajournal.biomedcentral.com/articles/10.1186/s1
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http://dx.doi.org/10.1186/s12936-018-2349-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5952413PMC
May 2018

Identification of Collateral Sensitivity to Dihydroorotate Dehydrogenase Inhibitors in Plasmodium falciparum.

ACS Infect Dis 2018 04 22;4(4):508-515. Epub 2018 Jan 22.

Department of Immunology and Infectious Diseases , Harvard T. H. Chan School of Public Health , 665 Huntington Avenue , Boston , Massachusetts 02115 , United States.

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http://dx.doi.org/10.1021/acsinfecdis.7b00217DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5899019PMC
April 2018

Inactivation of Plasmepsins 2 and 3 Sensitizes Plasmodium falciparum to the Antimalarial Drug Piperaquine.

Antimicrob Agents Chemother 2018 04 27;62(4). Epub 2018 Mar 27.

Centre de recherche en infectiologie du CHU de Québec-Université Laval, Québec City, Québec, Canada

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http://dx.doi.org/10.1128/AAC.02309-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5913920PMC
April 2018

Modeling the genetic relatedness of Plasmodium falciparum parasites following meiotic recombination and cotransmission.

PLoS Comput Biol 2018 01 9;14(1):e1005923. Epub 2018 Jan 9.

Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, United States of America.

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http://dx.doi.org/10.1371/journal.pcbi.1005923DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5777656PMC
January 2018

Global action for training in malaria elimination.

Malar J 2018 Jan 25;17(1):51. Epub 2018 Jan 25.

Department of Global Health and Population, Harvard T.H. Chan School of Public Health, Boston, USA.

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http://dx.doi.org/10.1186/s12936-018-2199-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5785838PMC
January 2018

Lysophosphatidylcholine Regulates Sexual Stage Differentiation in the Human Malaria Parasite Plasmodium falciparum.

Cell 2017 Dec 9;171(7):1532-1544.e15. Epub 2017 Nov 9.

Wellcome Centre for Molecular Parasitology, Institute of Infection, Immunity & Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK; Harvard T.H. Chan School of Public Health, Department of Immunology and Infectious Diseases, Boston, MA 02155, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2017.10.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5733390PMC
December 2017

Case report of Plasmodium ovale curtisi malaria in Sri Lanka: relevance for the maintenance of elimination status.

BMC Infect Dis 2017 04 24;17(1):307. Epub 2017 Apr 24.

Department of Parasitology, Faculty of Medicine, University of Colombo, 25, Kynsey Road, Colombo 8, Sri Lanka.

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http://dx.doi.org/10.1186/s12879-017-2411-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5404676PMC
April 2017

Intramolecular Diaza-Diels-Alder Protocol: A New Diastereoselective and Modular One-Step Synthesis of Constrained Polycyclic Frameworks.

Chemistry 2017 Mar 17;23(17):4137-4148. Epub 2017 Feb 17.

Sharjah Institute for Medical Research, University of Sharjah, P.O. Box 27272, Sharjah, UAE.

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http://dx.doi.org/10.1002/chem.201605231DOI Listing
March 2017

A Novel Methodology for Bioenergetic Analysis of Plasmodium falciparum Reveals a Glucose-Regulated Metabolic Shift and Enables Mode of Action Analyses of Mitochondrial Inhibitors.

ACS Infect Dis 2016 12 25;2(12):903-916. Epub 2016 Oct 25.

Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health , Boston, Massachusetts 02115, United States.

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http://dx.doi.org/10.1021/acsinfecdis.6b00101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5518782PMC
December 2016

Plasmodium falciparum Cyclic Amine Resistance Locus (PfCARL), a Resistance Mechanism for Two Distinct Compound Classes.

ACS Infect Dis 2016 11 7;2(11):816-826. Epub 2016 Apr 7.

Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health , Boston, Massachusetts 02115, United States.

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http://pubs.acs.org/doi/10.1021/acsinfecdis.6b00025
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http://dx.doi.org/10.1021/acsinfecdis.6b00025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5109296PMC
November 2016

Probing the Azaaurone Scaffold against the Hepatic and Erythrocytic Stages of Malaria Parasites.

ChemMedChem 2016 10 19;11(19):2194-2204. Epub 2016 Aug 19.

Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003, Lisboa, Portugal.

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http://dx.doi.org/10.1002/cmdc.201600327DOI Listing
October 2016

Methods to Increase the Sensitivity of High Resolution Melting Single Nucleotide Polymorphism Genotyping in Malaria.

J Vis Exp 2015 Nov 10(105):e52839. Epub 2015 Nov 10.

Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health; School of Nursing and Health Sciences, Simmons College.

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http://dx.doi.org/10.3791/52839DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4692701PMC
November 2015

Adaptive evolution of malaria parasites in French Guiana: Reversal of chloroquine resistance by acquisition of a mutation in pfcrt.

Proc Natl Acad Sci U S A 2015 Sep 10;112(37):11672-7. Epub 2015 Aug 10.

Laboratoire de parasitologie, WHO Collaborating Center for Surveillance of Anti-Malarial Drug Resistance, Centre National de Référence du paludisme, Laboratoire associé pour la région Antilles-Guyane, Institut Pasteur de la Guyane, 97300 Cayenne, French Guiana;

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http://www.pnas.org/lookup/doi/10.1073/pnas.1507142112
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http://dx.doi.org/10.1073/pnas.1507142112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4577156PMC
September 2015

Exploring the 3-piperidin-4-yl-1H-indole scaffold as a novel antimalarial chemotype.

Eur J Med Chem 2015 Sep 31;102:320-33. Epub 2015 Jul 31.

Research Institute for Medicines (iMed.ULisboa), Faculdade de Farmácia, Universidade de Lisboa, Av. Professor Gama Pinto, 1640-003 Lisbon, Portugal. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2015.07.047DOI Listing
September 2015

The cytoplasmic prolyl-tRNA synthetase of the malaria parasite is a dual-stage target of febrifugine and its analogs.

Sci Transl Med 2015 May;7(288):288ra77

Infectious Diseases Program, Broad Institute, Cambridge, MA 02142, USA. Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA. Center for Systems Biology, Massachusetts General Hospital, Boston, MA 02114, USA.

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http://dx.doi.org/10.1126/scitranslmed.aaa3575DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4675670PMC
May 2015

Development of a single nucleotide polymorphism barcode to genotype Plasmodium vivax infections.

PLoS Negl Trop Dis 2015 Mar 17;9(3):e0003539. Epub 2015 Mar 17.

Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts, United States of America; Broad Institute, Cambridge, Massachusetts, United States of America; Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, United States of America.

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http://dx.doi.org/10.1371/journal.pntd.0003539DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4362761PMC
March 2015

An adjustable gas-mixing device to increase feasibility of in vitro culture of Plasmodium falciparum parasites in the field.

PLoS One 2014 6;9(3):e90928. Epub 2014 Mar 6.

Department of Immunology & Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, United States of America; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0090928PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3946284PMC
February 2015

Enrichment of reticulocytes from whole blood using aqueous multiphase systems of polymers.

Am J Hematol 2015 Jan 18;90(1):31-6. Epub 2014 Oct 18.

School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts.

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http://dx.doi.org/10.1002/ajh.23860DOI Listing
January 2015

Plasmodium falciparum gene expression measured directly from tissue during human infection.

Genome Med 2014 29;6(11):110. Epub 2014 Nov 29.

Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA USA ; Broad Institute, Cambridge, MA USA ; University of Malawi College of Medicine, Blantyre, Malawi ; The Blantyre Malaria Project, Blantyre, Malawi ; Brigham and Women's Hospital, Boston, MA USA.

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http://dx.doi.org/10.1186/s13073-014-0110-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4269068PMC
December 2014

The Sri Lankan paradox: high genetic diversity in Plasmodium vivax populations despite decreasing levels of malaria transmission.

Parasitology 2014 Jun 14;141(7):880-90. Epub 2014 Feb 14.

Department of Parasitology, Faculty of Medicine, University of Colombo, Sri Lanka.

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http://dx.doi.org/10.1017/S0031182013002278DOI Listing
June 2014

In vitro resistance selections for Plasmodium falciparum dihydroorotate dehydrogenase inhibitors give mutants with multiple point mutations in the drug-binding site and altered growth.

J Biol Chem 2014 Jun 29;289(26):17980-95. Epub 2014 Apr 29.

From the Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts 02115, the Infectious Disease Initiative, Broad Institute, Cambridge, Massachusetts 02142

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http://dx.doi.org/10.1074/jbc.M114.558353DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4140291PMC
June 2014

On the road to eliminate malaria in Sri Lanka: lessons from history, challenges, gaps in knowledge and research needs.

Malar J 2014 Feb 18;13:59. Epub 2014 Feb 18.

Department of Parasitology, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka.

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http://dx.doi.org/10.1186/1475-2875-13-59DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3943480PMC
February 2014

Malaria life cycle intensifies both natural selection and random genetic drift.

Proc Natl Acad Sci U S A 2013 Dec 20;110(50):20129-34. Epub 2013 Nov 20.

Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138.

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http://dx.doi.org/10.1073/pnas.1319857110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3864301PMC
December 2013

Modulation of PF10_0355 (MSPDBL2) alters Plasmodium falciparum response to antimalarial drugs.

Antimicrob Agents Chemother 2013 Jul 15;57(7):2937-41. Epub 2013 Apr 15.

Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1128/AAC.02574-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3697352PMC
July 2013

Harnessing genomics and genome biology to understand malaria biology.

Nat Rev Genet 2012 Apr 12;13(5):315-28. Epub 2012 Apr 12.

Department of Immunology and Infectious Disease, Harvard School of Public Health, 665 Huntington Avenue, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1038/nrg3187DOI Listing
April 2012

A high-throughput screen targeting malaria transmission stages opens new avenues for drug development.

J Infect Dis 2011 May;203(10):1445-53

Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA.

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http://dx.doi.org/10.1093/infdis/jir037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3080890PMC
May 2011

Low-complexity regions in Plasmodium falciparum: missing links in the evolution of an extreme genome.

Mol Biol Evol 2010 Sep 28;27(9):2198-209. Epub 2010 Apr 28.

Department of Organismic and Evolutionary Biology, Harvard University, Boston, MA, USA.

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http://dx.doi.org/10.1093/molbev/msq108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2922621PMC
September 2010

A concise silylamine approach to 2-amino-3-hydroxy-indoles with potent in vivo antimalaria activity.

Org Lett 2010 Sep;12(18):3998-4001

Infectious Disease Initiative Program, The Broad Institute of Harvard and MIT, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA.

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http://dx.doi.org/10.1021/ol101566hDOI Listing
September 2010

Colorimetric high-throughput screen for detection of heme crystallization inhibitors.

Antimicrob Agents Chemother 2009 Jun 23;53(6):2564-8. Epub 2009 Mar 23.

Department of Immunology and Infectious Diseases, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA.

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http://aac.asm.org/cgi/doi/10.1128/AAC.01466-08
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http://dx.doi.org/10.1128/AAC.01466-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2687197PMC
June 2009

Patterns of gene-specific and total transcriptional activity during the Plasmodium falciparum intraerythrocytic developmental cycle.

Eukaryot Cell 2009 Mar 16;8(3):327-38. Epub 2009 Jan 16.

Department of Immunology and Infectious Diseases, Harvard School of Public Health, Harvard University, Boston, Massachusetts 02115, USA.

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http://ec.asm.org/lookup/doi/10.1128/EC.00340-08
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http://dx.doi.org/10.1128/EC.00340-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2653245PMC
March 2009

Type II NADH dehydrogenase of the respiratory chain of Plasmodium falciparum and its inhibitors.

Bioorg Med Chem Lett 2009 Feb 24;19(3):972-5. Epub 2008 Nov 24.

Department of Immunology and Infectious Disease, Harvard School of Public Health, Building 1, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.bmcl.2008.11.071DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4422330PMC
February 2009