Dwight Nissley

Dwight Nissley

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Dwight Nissley

Dwight Nissley

Publications by authors named "Dwight Nissley"

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The small molecule BI-2852 induces a nonfunctional dimer of KRAS.

Proc Natl Acad Sci U S A 2020 Feb 11. Epub 2020 Feb 11.

National Cancer Institute RAS Initiative, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, MD 21702;

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http://dx.doi.org/10.1073/pnas.1918164117DOI Listing
February 2020

Membrane curvature sensing of the lipid-anchored K-Ras small GTPase.

Life Sci Alliance 2019 08 11;2(4). Epub 2019 Jul 11.

Department of Integrative Biology and Pharmacology, University of Texas Health Science Center at Houston, Houston, TX, USA

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http://dx.doi.org/10.26508/lsa.201900343DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6625090PMC
August 2019

Structures of N-terminally processed KRAS provide insight into the role of N-acetylation.

Sci Rep 2019 Jul 19;9(1):10512. Epub 2019 Jul 19.

NCI RAS Initiative, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, MD, 21701, USA.

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http://dx.doi.org/10.1038/s41598-019-46846-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6642148PMC
July 2019

KRAS Prenylation Is Required for Bivalent Binding with Calmodulin in a Nucleotide-Independent Manner.

Biophys J 2019 03 15;116(6):1049-1063. Epub 2019 Feb 15.

NCI RAS Initiative, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, Maryland. Electronic address:

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http://dx.doi.org/10.1016/j.bpj.2019.02.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428923PMC
March 2019

Quantitative biophysical analysis defines key components modulating recruitment of the GTPase KRAS to the plasma membrane.

J Biol Chem 2019 02 17;294(6):2193-2207. Epub 2018 Dec 17.

From the NCI RAS Initiative, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, Maryland 21702,

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http://www.jbc.org/lookup/doi/10.1074/jbc.RA118.005669
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http://dx.doi.org/10.1074/jbc.RA118.005669DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369290PMC
February 2019

Direct molecular dissection of tumor parenchyma from tumor stroma in tumor xenograft using mass spectrometry-based glycoproteomics.

Oncotarget 2018 May 29;9(41):26431-26452. Epub 2018 May 29.

National Cancer Institute RAS Initiative, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, MD 21702, USA.

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http://dx.doi.org/10.18632/oncotarget.25449DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5995176PMC
May 2018

Tumor RAS Gene Expression Levels Are Influenced by the Mutational Status of RAS Genes and Both Upstream and Downstream RAS Pathway Genes.

Cancer Inform 2017 8;16:1176935117711944. Epub 2017 Jun 8.

Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD, USA.

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http://journals.sagepub.com/doi/10.1177/1176935117711944
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http://dx.doi.org/10.1177/1176935117711944DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5467702PMC
June 2017

RAS Proteins and Their Regulators in Human Disease.

Cell 2017 Jun;170(1):17-33

NCI RAS Initiative, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Frederick, MD 21701, USA; Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, 1450 3(rd) Street, San Francisco, CA 94158, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2017.06.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5555610PMC
June 2017

Structural basis of recognition of farnesylated and methylated KRAS4b by PDEδ.

Proc Natl Acad Sci U S A 2016 11 17;113(44):E6766-E6775. Epub 2016 Oct 17.

NCI RAS Initiative, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, MD 21701;

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http://dx.doi.org/10.1073/pnas.1615316113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5098621PMC
November 2016

Mass spectrometry in cancer biomarker research: a case for immunodepletion of abundant blood-derived proteins from clinical tissue specimens.

Biomark Med 2014 ;8(2):269-86

Laboratory of Proteomics & Analytical Technologies, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, National Cancer Institute at Frederick, PO Box B, Frederick, MD 21702, USA.

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http://dx.doi.org/10.2217/bmm.13.101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4201940PMC
October 2014

APOBEC3G hypermutates genomic DNA and inhibits Ty1 retrotransposition in yeast.

Proc Natl Acad Sci U S A 2005 Jul 6;102(28):9854-9. Epub 2005 Jul 6.

Department of Biochemistry, Molecular Biology, and Biophysics and Institute for Molecular Virology, University of Minnesota, Minneapolis, MN 55455, USA.

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http://dx.doi.org/10.1073/pnas.0501694102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1172225PMC
July 2005