Dustin E Schones

Dustin E Schones

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Dustin E Schones

Publications by authors named "Dustin E Schones"

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Hyperinsulinemia promotes aberrant histone acetylation in triple-negative breast cancer.

Epigenetics Chromatin 2019 Jul 17;12(1):44. Epub 2019 Jul 17.

Department of Diabetes Complications and Metabolism, Beckman Research Institute, City of Hope, Duarte, CA, 91010, USA.

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http://dx.doi.org/10.1186/s13072-019-0290-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6636093PMC
July 2019

LTRs activated by Epstein-Barr virus-induced transformation of B cells alter the transcriptome.

Genome Res 2018 12 31;28(12):1791-1798. Epub 2018 Oct 31.

Department of Diabetes Complications and Metabolism, Beckman Research Institute, City of Hope, Duarte, California 91010, USA.

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http://genome.cshlp.org/lookup/doi/10.1101/gr.233585.117
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http://dx.doi.org/10.1101/gr.233585.117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6280761PMC
December 2018

Estrogens and selective estrogen receptor modulators differentially antagonize Runx2 in ST2 mesenchymal progenitor cells.

J Steroid Biochem Mol Biol 2018 10 8;183:10-17. Epub 2018 May 8.

Center of Craniofacial Molecular Biology, Ostrow School of Dentistry, University of Southern California, Los Angeles, CA, USA; Departments of Biochemistry and Molecular Medicine, Los Angeles, CA, USA; Institute for Genetic Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA; Departments of Orthopedic Surgery, Los Angeles, CA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jsbmb.2018.05.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6128776PMC
October 2018

Diabetes Mellitus-Induced Long Noncoding RNA Dnm3os Regulates Macrophage Functions and Inflammation via Nuclear Mechanisms.

Arterioscler Thromb Vasc Biol 2018 08;38(8):1806-1820

From the Department of Diabetes Complications and Metabolism, Beckman Research Institute of City of Hope, Duarte, CA (S. Das, M.A.R., P.S., K.S., L.L., M.W., V.A., R.G., L.Z., D.E.S., R.N.).

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https://www.ahajournals.org/doi/10.1161/ATVBAHA.117.310663
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http://dx.doi.org/10.1161/ATVBAHA.117.310663DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6202204PMC
August 2018

Chromatin modifications in metabolic disease: Potential mediators of long-term disease risk.

Wiley Interdiscip Rev Syst Biol Med 2018 07 25;10(4):e1416. Epub 2018 Jan 25.

Department of Diabetes Complications and Metabolism, Irell & Manella Graduate School, City of Hope, Duarte, California.

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http://dx.doi.org/10.1002/wsbm.1416DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6002879PMC
July 2018

Regulation of angiotensin II actions by enhancers and super-enhancers in vascular smooth muscle cells.

Nat Commun 2017 11 13;8(1):1467. Epub 2017 Nov 13.

Department of Diabetes Complications and Metabolism, Diabetes Metabolism Research Institute, Beckman Research Institute of City of Hope, Duarte, CA, 91010, USA.

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http://www.nature.com/articles/s41467-017-01629-7
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http://dx.doi.org/10.1038/s41467-017-01629-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5684340PMC
November 2017

Vertical sleeve gastrectomy reverses diet-induced gene-regulatory changes impacting lipid metabolism.

Sci Rep 2017 07 13;7(1):5274. Epub 2017 Jul 13.

Department of Diabetes Complications and Metabolism, Beckman Research Institute, City of Hope, Duarte, CA, USA.

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http://dx.doi.org/10.1038/s41598-017-05349-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5509746PMC
July 2017

Transgenerational programming of longevity through E(z)-mediated histone H3K27 trimethylation in .

Aging (Albany NY) 2016 11;8(11):2988-3008

Department of Biology, Dart Neuroscience LLC, San Diego, CA 92131, USA.

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http://dx.doi.org/10.18632/aging.101107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5191882PMC
November 2016

Chromatin variation associated with liver metabolism is mediated by transposable elements.

Epigenetics Chromatin 2016 8;9:28. Epub 2016 Jul 8.

Department of Diabetes Complications and Metabolism, Beckman Research Institute, City of Hope, Duarte, CA USA ; Irell & Manella Graduate School of Biological Sciences, City of Hope, Duarte, CA USA.

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http://dx.doi.org/10.1186/s13072-016-0078-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4939004PMC
July 2016

Persistent Chromatin Modifications Induced by High Fat Diet.

J Biol Chem 2016 May 22;291(20):10446-55. Epub 2016 Mar 22.

From the Department of Diabetes Complications and Metabolism, Beckman Research Institute, and Irell and Manella Graduate School of Biological Sciences, City of Hope, Duarte, California 91010

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http://dx.doi.org/10.1074/jbc.M115.711028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4865896PMC
May 2016

Chromatin Modifications Associated With Diabetes and Obesity.

Arterioscler Thromb Vasc Biol 2015 Jul 4;35(7):1557-61. Epub 2015 Jun 4.

From the Department of Diabetes Complications and Metabolism, Beckman Research Institute of City of Hope, Duarte, CA.

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http://dx.doi.org/10.1161/ATVBAHA.115.305041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4482788PMC
July 2015

Distinct roles of DNMT1-dependent and DNMT1-independent methylation patterns in the genome of mouse embryonic stem cells.

Genome Biol 2015 Jun 2;16:115. Epub 2015 Jun 2.

Department of Environmental Health Sciences, Laboratory of Human Environmental Epigenomes, Bloomberg School of Public Health, Johns Hopkins University, 615 N. Wolfe Street, Room E7816, Baltimore, MD, 21205, USA.

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http://dx.doi.org/10.1186/s13059-015-0685-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4474455PMC
June 2015

Epigenetic dysregulation by nickel through repressive chromatin domain disruption.

Proc Natl Acad Sci U S A 2014 Oct 22;111(40):14631-6. Epub 2014 Sep 22.

Department of Environmental Medicine, New York University School of Medicine, Tuxedo, NY 10987;

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http://www.pnas.org/lookup/doi/10.1073/pnas.1406923111
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http://dx.doi.org/10.1073/pnas.1406923111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4210008PMC
October 2014

G9a/GLP-dependent H3K9me2 patterning alters chromatin structure at CpG islands in hematopoietic progenitors.

Epigenetics Chromatin 2014 10;7:23. Epub 2014 Sep 10.

Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.

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http://dx.doi.org/10.1186/1756-8935-7-23DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4166411PMC
September 2014

Open chromatin profiling in mice livers reveals unique chromatin variations induced by high fat diet.

J Biol Chem 2014 Aug 8;289(34):23557-67. Epub 2014 Jul 8.

Cancer Biology, Beckman Research Institute and the Irell & Manella Graduate School of Biological Sciences, City of Hope, Duarte, California 91010 and

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http://dx.doi.org/10.1074/jbc.M114.581439DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4156056PMC
August 2014

Differential effects of RUNX2 on the androgen receptor in prostate cancer: synergistic stimulation of a gene set exemplified by SNAI2 and subsequent invasiveness.

Cancer Res 2014 May 19;74(10):2857-68. Epub 2014 Mar 19.

Authors' Affiliations: Departments of Biochemistry and Molecular Biology, Orthopedic Surgery, Preventive Medicine, and Medicine; Institute for Genetic Medicine; USC/Norris Comprehensive Cancer Center, Keck School of Medicine of the University of Southern California, Los Angeles; Departments of Molecular Pharmacology and Cancer Biology, Beckman Research Institute, City of Hope, Duarte, CaliforniaAuthors' Affiliations: Departments of Biochemistry and Molecular Biology, Orthopedic Surgery, Preventive Medicine, and Medicine; Institute for Genetic Medicine; USC/Norris Comprehensive Cancer Center, Keck School of Medicine of the University of Southern California, Los Angeles; Departments of Molecular Pharmacology and Cancer Biology, Beckman Research Institute, City of Hope, Duarte, CaliforniaAuthors' Affiliations: Departments of Biochemistry and Molecular Biology, Orthopedic Surgery, Preventive Medicine, and Medicine; Institute for Genetic Medicine; USC/Norris Comprehensive Cancer Center, Keck School of Medicine of the University of Southern California, Los Angeles; Departments of Molecular Pharmacology and Cancer Biology, Beckman Research Institute, City of Hope, Duarte, California

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http://dx.doi.org/10.1158/0008-5472.CAN-13-2003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4051204PMC
May 2014

A structural-based strategy for recognition of transcription factor binding sites.

PLoS One 2013 8;8(1):e52460. Epub 2013 Jan 8.

Laboratory of Molecular Modeling and Design, Dalian Institute of Chemical Physics, The Chinese Academy of Sciences, Dalian, Liaoning, China.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0052460PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3540023PMC
August 2013

The ATP-dependent chromatin remodeling enzyme Fun30 represses transcription by sliding promoter-proximal nucleosomes.

J Biol Chem 2013 Aug 18;288(32):23182-93. Epub 2013 Jun 18.

Institute of Molecular Medicine and Genetics, Department of Neurology, Medical College of Georgia, Georgia Regents University, Augusta, Georgia 30912, USA.

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http://dx.doi.org/10.1074/jbc.M113.471979DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3743490PMC
August 2013

Novel long noncoding RNAs are regulated by angiotensin II in vascular smooth muscle cells.

Circ Res 2013 Jul 22;113(3):266-78. Epub 2013 May 22.

Department of Diabetes and Cancer Biology, Beckman Research Institute, City of Hope, Duarte, CA, USA.

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http://dx.doi.org/10.1161/CIRCRESAHA.112.300849DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3763837PMC
July 2013

Using epigenetic mechanisms to understand the impact of common disease causing alleles.

Curr Opin Immunol 2012 Oct 2;24(5):558-63. Epub 2012 Aug 2.

Department of Diabetes, Beckman Research Institute of the City of Hope, Duarte, CA 91010, United States.

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http://dx.doi.org/10.1016/j.coi.2012.07.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3478440PMC
October 2012

Genome-wide approaches to studying yeast chromatin modifications.

Methods Mol Biol 2011 ;759:61-71

City of Hope, Duarte, CA, USA.

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http://dx.doi.org/10.1007/978-1-61779-173-4_4DOI Listing
December 2011

The chromatin-binding protein HMGN1 regulates the expression of methyl CpG-binding protein 2 (MECP2) and affects the behavior of mice.

J Biol Chem 2011 Dec 17;286(49):42051-62. Epub 2011 Oct 17.

Protein Section, Laboratory of Metabolism, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1074/jbc.M111.300541DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3234940PMC
December 2011

Regulation of nucleosome landscape and transcription factor targeting at tissue-specific enhancers by BRG1.

Genome Res 2011 Oct 27;21(10):1650-8. Epub 2011 Jul 27.

Laboratory of Molecular Immunology, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1101/gr.121145.111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3202282PMC
October 2011

Genomic profiling of HMGN1 reveals an association with chromatin at regulatory regions.

Mol Cell Biol 2011 Feb 20;31(4):700-9. Epub 2010 Dec 20.

Laboratory of Molecular Immunology, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1128/MCB.00740-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3028635PMC
February 2011

Monovalent and unpoised status of most genes in undifferentiated cell-enriched Drosophila testis.

Genome Biol 2010 15;11(4):R42. Epub 2010 Apr 15.

Department of Biology, The Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218, USA.

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http://dx.doi.org/10.1186/gb-2010-11-4-r42DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2884545PMC
October 2010

Chromatin poises miRNA- and protein-coding genes for expression.

Genome Res 2009 Oct 27;19(10):1742-51. Epub 2009 Aug 27.

Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1101/gr.090951.109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2765269PMC
October 2009

Genome-wide mapping of HATs and HDACs reveals distinct functions in active and inactive genes.

Cell 2009 Sep 20;138(5):1019-31. Epub 2009 Aug 20.

Laboratory of Molecular Immunology, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.cell.2009.06.049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2750862PMC
September 2009

A clustering approach for identification of enriched domains from histone modification ChIP-Seq data.

Bioinformatics 2009 Aug 8;25(15):1952-8. Epub 2009 Jun 8.

Department of Physics, The George Washington University, Washington, DC 20052, USA.

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http://dx.doi.org/10.1093/bioinformatics/btp340DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2732366PMC
August 2009

Native chromatin preparation and Illumina/Solexa library construction.

Cold Spring Harb Protoc 2009 Jun;2009(6):pdb.prot5237

Laboratory of Molecular Immunology, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1101/pdb.prot5237DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3541822PMC
June 2009

Characterization of human epigenomes.

Curr Opin Genet Dev 2009 Apr 18;19(2):127-34. Epub 2009 Mar 18.

Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.gde.2009.02.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2699568PMC
April 2009

Determination of enriched histone modifications in non-genic portions of the human genome.

BMC Genomics 2009 Mar 31;10:143. Epub 2009 Mar 31.

Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.

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http://dx.doi.org/10.1186/1471-2164-10-143DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2667539PMC
March 2009

Down-regulation of Gfi-1 expression by TGF-beta is important for differentiation of Th17 and CD103+ inducible regulatory T cells.

J Exp Med 2009 Feb 2;206(2):329-41. Epub 2009 Feb 2.

Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1084/jem.20081666DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2646571PMC
February 2009

Global analysis of the insulator binding protein CTCF in chromatin barrier regions reveals demarcation of active and repressive domains.

Genome Res 2009 Jan 3;19(1):24-32. Epub 2008 Dec 3.

Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1101/gr.082800.108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2612964PMC
January 2009

Chromatin signatures in multipotent human hematopoietic stem cells indicate the fate of bivalent genes during differentiation.

Cell Stem Cell 2009 Jan;4(1):80-93

Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S193459090800582
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http://dx.doi.org/10.1016/j.stem.2008.11.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2785912PMC
January 2009

Priming for T helper type 2 differentiation by interleukin 2-mediated induction of interleukin 4 receptor alpha-chain expression.

Nat Immunol 2008 Nov 28;9(11):1288-96. Epub 2008 Sep 28.

Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1038/ni.1656DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2762127PMC
November 2008

Combinatorial patterns of histone acetylations and methylations in the human genome.

Nat Genet 2008 Jul 15;40(7):897-903. Epub 2008 Jun 15.

Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, US National Institutes of Health, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1038/ng.154DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2769248PMC
July 2008

Genome-wide approaches to studying chromatin modifications.

Nat Rev Genet 2008 Mar;9(3):179-91

Laboratory of Molecular Immunology, The National Heart, Lung and Blood Institute, National Institutes of Health, Building 10, Room 7B05, 9,000 Rockville Pike, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1038/nrg2270DOI Listing
March 2008

Dynamic regulation of nucleosome positioning in the human genome.

Cell 2008 Mar;132(5):887-98

Laboratory of Molecular Immunology, The National Heart, Lung and Blood Institute, NIH, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.cell.2008.02.022DOI Listing
March 2008

High-resolution profiling of histone methylations in the human genome.

Cell 2007 May;129(4):823-37

Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.cell.2007.05.009DOI Listing
May 2007

Statistical significance of cis-regulatory modules.

BMC Bioinformatics 2007 Jan 22;8:19. Epub 2007 Jan 22.

Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.

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http://dx.doi.org/10.1186/1471-2105-8-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1796902PMC
January 2007

Similarity of position frequency matrices for transcription factor binding sites.

Bioinformatics 2005 Feb 19;21(3):307-13. Epub 2004 Aug 19.

Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA.

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http://dx.doi.org/10.1093/bioinformatics/bth480DOI Listing
February 2005