Dustin Deming

Division of Hematology and Oncology, Department of Medicine, University of Wisconsin Carbone Cancer Center, University of Wisconsin-Madison, 1111 Highland Avenue, Madison, WI, 53705, USA.

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April 2020

Phase 1 dose escalation trial of TAS-102 (trifluridine/tipiracil) and temozolomide in the treatment of advanced neuroendocrine tumors.

Authors:

Nataliya V Uboha Sam J Lubner Noelle K LoConte Daniel L Mulkerin Jens C Eickhoff Dustin A Deming

Invest New Drugs 2020 10 6;38(5):1520-1525. Epub 2020 Apr 6.

Carbone Cancer Center, University of Wisconsin, Madison, WI, USA.

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October 2020

Acquisition of Cabozantinib-Sensitive MET D1228N Mutation During Progression on Crizotinib in MET-Amplified Triple-Negative Breast Cancer.

Authors:

Benjamin M Parsons David R Meier Craig S Richmond Grzegorz T Gurda Kristopher A Lofgren Mark E Burkard Dustin A Deming Paraic A Kenny

Clin Breast Cancer 2020 Aug 19;20(4):e433-e438. Epub 2020 Feb 19.

Kabara Cancer Research Institute, Gundersen Health System, La Crosse, WI; Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI. Electronic address:

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August 2020

The evolving treatment paradigm for BRAF V600 mutant colorectal cancer.

Authors:

Jeremy D Kratz Dustin A Deming

Ann Transl Med 2019 Dec;7(Suppl 8):S257

Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.

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December 2019

Small Bowel Adenocarcinoma, Version 1.2020, NCCN Clinical Practice Guidelines in Oncology.

J Natl Compr Canc Netw 2019 09;17(9):1109-1133

National Comprehensive Cancer Network.

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September 2019

Correction: A phase 2 randomised study of veliparib plus FOLFIRI±bevacizumab versus placebo plus FOLFIRI±bevacizumab in metastatic colorectal cancer.

Authors:

Vera Gorbunova J Thaddeus Beck Ralf-Dieter Hofheinz Pilar Garcia-Alfonso Marina Nechaeva Antonio Cubillo Gracian Laszlo Mangel Elena Elez Fernandez Dustin A Deming Ramesh K Ramanathan Alison H Torres Danielle Sullivan Yan Luo Jordan D Berlin

Br J Cancer 2019 Aug;121(5):429-430

Vanderbilt-Ingram Cancer Center, Nashville, TN, USA.

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August 2019

Patient-Derived Cancer Organoid Cultures to Predict Sensitivity to Chemotherapy and Radiation.

Clin Cancer Res 2019 09 7;25(17):5376-5387. Epub 2019 Jun 7.

University of Wisconsin Carbone Cancer Center, Madison, Wisconsin.

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September 2019

Targeted Therapy in Metastatic Colorectal Cancer: Current Standards and Novel Agents in Review.

Authors:

Rebecca A DeStefanis Jeremy D Kratz Philip B Emmerich Dustin A Deming

Curr Colorectal Cancer Rep 2019 Apr 20;15(2):61-69. Epub 2019 Mar 20.

Division of Hematology and Oncology, Department of Medicine, University of Wisconsin-Madison.

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April 2019

Targeting β-catenin overcomes MEK inhibition resistance in colon cancer with KRAS and PIK3CA mutations.

Br J Cancer 2019 04 4;120(9):941-951. Epub 2019 Apr 4.

Asan Institute for Life Science, Asan Medical Center, Seoul, Republic of Korea.

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April 2019

Metastatic Bulk Independently Predicts Outcomes for EGFR Precision Targeting in Colorectal Cancer.

Authors:

Jeremy D Kratz Nataliya V Uboha Sam J Lubner Daniel L Mulkerin Linda Clipson Yanyao Yi Menggang Yu Kristina A Matkowskyj Noelle K LoConte Dustin A Deming

J Natl Compr Canc Netw 2018 12;16(12):1442-1450

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December 2018

A phase 2 randomised study of veliparib plus FOLFIRI±bevacizumab versus placebo plus FOLFIRI±bevacizumab in metastatic colorectal cancer.

Authors:

Vera Gorbunova J Thaddeus Beck Ralf-Dieter Hofheinz Pilar Garcia-Alfonso Marina Nechaeva Antonio Cubillo Gracian Laszlo Mangel Elena Elez Fernandez Dustin A Deming Ramesh K Ramanathan Alison H Torres Danielle Sullivan Yan Luo Jordan D Berlin

Br J Cancer 2019 01 11;120(2):183-189. Epub 2018 Dec 11.

Vanderbilt-Ingram Cancer Center, Nashville, TN, USA.

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January 2019

Activating Mutations in Contribute to Anal Carcinogenesis in the Presence or Absence of HPV-16 Oncogenes.

Authors:

Myeong-Kyun Shin Susan Payne Andrea Bilger Kristina A Matkowskyj Evie Carchman Dominique S Meyer Mohamed Bentires-Alj Dustin A Deming Paul F Lambert

Clin Cancer Res 2019 03 7;25(6):1889-1900. Epub 2018 Dec 7.

McArdle Laboratory for Cancer Research, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.

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March 2019

MTORC1/2 Inhibition as a Therapeutic Strategy for Mutant Cancers.

Mol Cancer Ther 2019 02 13;18(2):346-355. Epub 2018 Nov 13.

Division of Hematology and Oncology, Department of Medicine, University of Wisconsin-Madison, Madison, Wisconsin.

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February 2019

Molecular Evolution of a Glioblastoma Controlled With Tumor Treating Fields and Concomitant Temozolomide.

Authors:

H Ian Robins HuyTram N Nguyen Aaron Field Steven Howard Shahriar Salamat Dustin A Deming

Front Oncol 2018 15;8:451. Epub 2018 Oct 15.

Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, United States.

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October 2018

The conserved protective cyclic AMP-phosphodiesterase function PDE4B is expressed in the adenoma and adjacent normal colonic epithelium of mammals and silenced in colorectal cancer.

Authors:

Jennifer K Pleiman Amy A Irving Zhishi Wang Erik Toraason Linda Clipson William F Dove Dustin A Deming Michael A Newton

PLoS Genet 2018 09 6;14(9):e1007611. Epub 2018 Sep 6.

Department of Statistics, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.

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September 2018

Rectal Cancer, Version 2.2018, NCCN Clinical Practice Guidelines in Oncology.

J Natl Compr Canc Netw 2018 07;16(7):874-901

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July 2018

Anal Carcinoma, Version 2.2018, NCCN Clinical Practice Guidelines in Oncology.

J Natl Compr Canc Netw 2018 07;16(7):852-871

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July 2018

E4206: AMG 706 and Octreotide in Patients with Low-Grade Neuroendocrine Tumors.

Authors:

Sam Lubner Yang Feng Mary Mulcahy Peter O'Dwyer Guang-Yu Giang J Louis Hinshaw Dustin Deming Leonard Klein Ursina Teitelbaum Jennifer Payne Paul Engstrom Philip Stella Neal Meropol Al Benson

Oncologist 2018 09 31;23(9):1006-e104. Epub 2018 May 31.

Northwestern University, Evanston, Illinois, USA.

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September 2018

NCCN Guidelines Insights: Colon Cancer, Version 2.2018.

J Natl Compr Canc Netw 2018 Apr;16(4):359-369

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April 2018

Tailoring the colorectal cancer disease assessment to the treatment strategy.

Authors:

Dustin A Deming

Gut 2018 06 21;67(6):996-997. Epub 2017 Dec 21.

Division of Hematology and Oncology, Department of Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA.

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June 2018

CT texture features of liver parenchyma for predicting development of metastatic disease and overall survival in patients with colorectal cancer.

Authors:

Scott J Lee Ryan Zea David H Kim Meghan G Lubner Dustin A Deming Perry J Pickhardt

Eur Radiol 2018 Apr 21;28(4):1520-1528. Epub 2017 Nov 21.

Department of Radiology, University of Wisconsin School of Medicine and Public Health, 600 Highland Avenue, Madison, WI, 53792, USA.

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April 2018

A Blueprint to Advance Colorectal Cancer Immunotherapies.

Cancer Immunol Res 2017 11 16;5(11):942-949. Epub 2017 Oct 16.

Northwestern University, Chicago, Illinois.

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November 2017

Versican-Derived Matrikines Regulate Batf3-Dendritic Cell Differentiation and Promote T Cell Infiltration in Colorectal Cancer.

Authors:

Chelsea Hope Philip B Emmerich Athanasios Papadas Adam Pagenkopf Kristina A Matkowskyj Dana R Van De Hey Susan N Payne Linda Clipson Natalie S Callander Peiman Hematti Shigeki Miyamoto Michael G Johnson Dustin A Deming Fotis Asimakopoulos

J Immunol 2017 09 28;199(5):1933-1941. Epub 2017 Jul 28.

Division of Hematology and Medical Oncology, Department of Medicine, University of Wisconsin School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53705;

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September 2017

Primary and acquired resistance to biologic therapies in gastrointestinal cancers.

Authors:

Sam J Lubner Nataliya V Uboha Dustin A Deming

J Gastrointest Oncol 2017 Jun;8(3):499-512

Department of Medicine, Hematology-Oncology Section, University of Wisconsin Carbone Cancer Center, Madison, WI 53792, USA.

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June 2017

Implementation and Clinical Utility of an Integrated Academic-Community Regional Molecular Tumor Board.

JCO Precis Oncol 2017 5;1. Epub 2017 Jul 5.

, , , , , , , , , , , , , , and , University of Wisconsin-Madison; , University of Wisconsin School of Medicine and Public Health; , UW Health; , William S. Middleton VA Medical Center, Madison; and , Gundersen Health System, La Crosse; , Aurora Health Care, Milwaukee; and , Green Bay Oncology, Green Bay, WI.

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July 2017

Safety and tolerability of veliparib combined with capecitabine plus radiotherapy in patients with locally advanced rectal cancer: a phase 1b study.

Authors:

Brian G Czito Dustin A Deming Gayle S Jameson Mary F Mulcahy Houman Vaghefi Matthew W Dudley Kyle D Holen Angela DeLuca Rajendar K Mittapalli Wijith Munasinghe Lei He John R Zalcberg Samuel Y Ngan Philip Komarnitsky Michael Michael

Lancet Gastroenterol Hepatol 2017 06 27;2(6):418-426. Epub 2017 Mar 27.

Peter MacCallum Cancer Centre, East Melbourne, VIC, Australia.

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June 2017

Colon Cancer, Version 1.2017, NCCN Clinical Practice Guidelines in Oncology.

J Natl Compr Canc Netw 2017 03;15(3):370-398

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March 2017

Using cancer genomics to guide clinical decisions.

Authors:

Mark E Burkard Dustin A Deming Josh Lauring

Cancer 2017 04 2;123(8):1288-1291. Epub 2017 Mar 2.

Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland.

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April 2017

Nivolumab for previously treated unresectable metastatic anal cancer (NCI9673): a multicentre, single-arm, phase 2 study.

Lancet Oncol 2017 04 18;18(4):446-453. Epub 2017 Feb 18.

The University of Texas-MD Anderson Cancer Center, Houston, TX, USA. Electronic address:

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April 2017

Dual PI3K/mTOR Inhibition in Colorectal Cancers with and Mutations.

Authors:

Tyler M Foley Susan N Payne Cheri A Pasch Alex E Yueh Dana R Van De Hey Demetra P Korkos Linda Clipson Molly E Maher Kristina A Matkowskyj Michael A Newton Dustin A Deming

Mol Cancer Res 2017 02 9;15(3):317-327. Epub 2017 Feb 9.

Division of Hematology and Oncology, Department of Medicine, University of Wisconsin-Madison, Madison, Wisconsin.

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February 2017

Advances in immunotherapeutic strategies for colorectal cancer commentary on: tumoral immune cell exploitation in colorectal cancer metastases can be targeted effectively by anti-CCR5 therapy in cancer patients by Halama et al.

Authors:

Dustin A Deming

J Immunother Cancer 2016 20;4:93. Epub 2016 Dec 20.

Division of Hematology and Oncology, Department of Medicine, University of Wisconsin-Madison, Madison, WI USA ; University of Wisconsin Carbone Cancer Center, Madison, WI USA ; McArdle Laboratory for Cancer Research, Department of Oncology, University of Wisconsin-Madison, Madison, WI USA ; William S Middleton Memorial Veterans Hospital, Madison, WI USA.

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December 2016

The effects of tumor treating fields and temozolomide in MGMT expressing and non-expressing patient-derived glioblastoma cells.

Authors:

Paul A Clark Jordan T Gaal Joslyn K Strebe Cheri A Pasch Dustin A Deming John S Kuo H Ian Robins

J Clin Neurosci 2017 Feb 16;36:120-124. Epub 2016 Nov 16.

University of Wisconsin Carbone Cancer Center, UWSMPH, United States; Division of Hematology and Oncology, Department of Medicine, UWSMPH, United States; William S Middleton Memorial Veterans Hospital, Madison, WI, United States; Department of Neurology, UWSMPH, United States; Department of Human Oncology, UWSMPH, United States. Electronic address:

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February 2017

The Multidisciplinary Management of Colorectal Cancer: Present and Future Paradigms.

Authors:

Chelsie K Sievers Jeremy D Kratz Luke D Zurbriggen Noelle K LoConte Sam J Lubner Natalya Uboha Daniel Mulkerin Kristina A Matkowskyj Dustin A Deming

Clin Colon Rectal Surg 2016 Sep;29(3):232-8

Division of Hematology and Oncology, Department of Medicine, University of Wisconsin, Madison, Wisconsin; University of Wisconsin Carbone Cancer Center, University of Wisconsin, Madison, Wisconsin; William S Middleton Memorial Veterans Hospital, Madison, Wisconsin.

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September 2016

Molecular Profiles Guide Colorectal Cancer Treatment.

Authors:

Jeremy D Kratz Anita A Turk Chelsie K Sievers Linda Clipson Kristina A Matkowskyj Dustin A Deming

Fed Pract 2016 May;33(Suppl 4):50S-53S

is an internal medicine resident; is an oncology fellow; is a graduate student; is a researcher; is a surgical pathologist; and is a medical oncologist and translational colorectal cancer researcher; all at the University of Wisconsin-Madison School of Medicine and Public Health. Dr. Matkowskyj and Dr. Deming are also staff physicians at the William S. Middleton Memorial Veterans Hospital in Madison, Wisconsin.

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May 2016

Colon Cancer Tumorigenesis Initiated by the H1047R Mutant PI3K.

Authors:

Alexander E Yueh Susan N Payne Alyssa A Leystra Dana R Van De Hey Tyler M Foley Cheri A Pasch Linda Clipson Kristina A Matkowskyj Dustin A Deming

PLoS One 2016 10;11(2):e0148730. Epub 2016 Feb 10.

Division of Hematology and Oncology, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, United States of America.

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July 2016

A phase I study of selumetinib (AZD6244/ARRY-142866), a MEK1/2 inhibitor, in combination with cetuximab in refractory solid tumors and KRAS mutant colorectal cancer.

Authors:

Dustin A Deming Ludmila L Cavalcante Sam J Lubner Daniel L Mulkerin Noelle K LoConte Jens C Eickhoff Jill M Kolesar Suzanne Fioravanti Tim F Greten Kathryn Compton Austin G Doyle George Wilding Austin Duffy Glenn Liu

Invest New Drugs 2016 Apr 14;34(2):168-75. Epub 2015 Dec 14.

University of Wisconsin-Madison Carbone Cancer Center, 600 Highland Avenue, K6/544 CSC, Madison, WI, 53792, USA.

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April 2016

Adjuvant Chemotherapy for Stage II Rectal Cancer.

Authors:

Dustin Deming Nataliya Uboha S Yousuf Zafar Stephen Rosenberg Michael Bassetti Sean Glasgow Ernest C Borden Sam Lubner

Semin Oncol 2015 Dec 21;42(6):e99-107. Epub 2015 Sep 21.

University of Wisconsin Carbone Cancer Center, Madison, WI. Electronic address:

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December 2015

Precision medicine in colorectal cancer: the molecular profile alters treatment strategies.

Authors:

Nguyen H Tran Ludmila L Cavalcante Sam J Lubner Daniel L Mulkerin Noelle K LoConte Linda Clipson Kristina A Matkowskyj Dustin A Deming

Ther Adv Med Oncol 2015 Sep;7(5):252-62

Division of Hematology and Oncology, Department of Medicine, University of Wisconsin-Madison School of Medicine and Public Health, 600 Highland Avenue, K6/544, Madison, WI 53792, USA.

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September 2015

Colon Tumors with the Simultaneous Induction of Driver Mutations in APC, KRAS, and PIK3CA Still Progress through the Adenoma-to-carcinoma Sequence.

Authors:

Jamie N Hadac Alyssa A Leystra Terrah J Paul Olson Molly E Maher Susan N Payne Alexander E Yueh Alexander R Schwartz Dawn M Albrecht Linda Clipson Cheri A Pasch Kristina A Matkowskyj Richard B Halberg Dustin A Deming

Cancer Prev Res (Phila) 2015 Oct 14;8(10):952-61. Epub 2015 Aug 14.

Division of Hematology and Oncology, University of Wisconsin, Madison, Wisconsin. University of Wisconsin Carbone Cancer Center, University of Wisconsin, Madison, Wisconsin. William S Middleton Memorial Veterans Hospital, Madison, Wisconsin.

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October 2015

A multicenter phase 1 study of γ -secretase inhibitor RO4929097 in combination with capecitabine in refractory solid tumors.

Authors:

Noelle K LoConte Albiruni R A Razak Percy Ivy Amye Tevaarwerk Rachael Leverence Jill Kolesar Lillian Siu Sam J Lubner Daniel L Mulkerin William R Schelman Dustin A Deming Kyle D Holen Lakeesha Carmichael Jens Eickhoff Glenn Liu

Invest New Drugs 2015 Feb 17;33(1):169-76. Epub 2014 Oct 17.

University of Wisconsin Carbone Cancer Center, 600 Highland Ave, CSC K4/548, Madison, WI, 53792, USA,

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February 2015

Phospholipid ether analogs for the detection of colorectal tumors.

Authors:

Dustin A Deming Molly E Maher Alyssa A Leystra Joseph P Grudzinski Linda Clipson Dawn M Albrecht Mary Kay Washington Kristina A Matkowskyj Lance T Hall Sam J Lubner Jamey P Weichert Richard B Halberg

PLoS One 2014 6;9(10):e109668. Epub 2014 Oct 6.

Division of Gastroenterology and Hepatology, Department of Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.

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December 2015

Mailed invitations for colorectal screening are effective in increasing screening participation in uninsured adults with faecal immunochemical testing: the preferred screening modality.

Authors:

Noelle K LoConte Dustin A Deming

Evid Based Med 2014 Aug 12;19(4):145. Epub 2014 Apr 12.

Department of Medicine, University of Wisconsin Carbone Cancer Center, Madison, Wisconsin, USA.

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August 2014

Dynamic tumor growth patterns in a novel murine model of colorectal cancer.

Authors:

Terrah J Paul Olson Jamie N Hadac Chelsie K Sievers Alyssa A Leystra Dustin A Deming Christopher D Zahm Dawn M Albrecht Alice Nomura Laura A Nettekoven Lauren K Plesh Linda Clipson Ruth Sullivan Michael A Newton William R Schelman Richard B Halberg

Cancer Prev Res (Phila) 2014 Jan 6;7(1):105-13. Epub 2013 Nov 6.

University of Wisconsin-Madison K4/532 Clinical Science Center, 600 Highland Avenue, Madison, WI 53792.

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January 2014

A Phase I study of intermittently dosed vorinostat in combination with bortezomib in patients with advanced solid tumors.

Authors:

Dustin A Deming Jacob Ninan Howard H Bailey Jill M Kolesar Jens Eickhoff Joel M Reid Matthew M Ames Renee M McGovern Dona Alberti Rebecca Marnocha Igor Espinoza-Delgado John Wright George Wilding William R Schelman

Invest New Drugs 2014 Apr 10;32(2):323-9. Epub 2013 Oct 10.

University of Wisconsin Carbone Cancer Center, 600 Highland Avenue, K4/530 CSC, Madison, WI, 53792, USA.

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April 2014

Transformation of epithelial cells through recruitment leads to polyclonal intestinal tumors.

Authors:

Andrew T Thliveris Brittany Schwefel Linda Clipson Lauren Plesh Christopher D Zahm Alyssa A Leystra Mary Kay Washington Ruth Sullivan Dustin A Deming Michael A Newton Richard B Halberg

Proc Natl Acad Sci U S A 2013 Jul 24;110(28):11523-8. Epub 2013 Jun 24.

Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, WI 53704, USA.

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July 2013

mTOR inhibition elicits a dramatic response in PI3K-dependent colon cancers.

Authors:

Dustin A Deming Alyssa A Leystra Mohammed Farhoud Laura Nettekoven Linda Clipson Dawn Albrecht Mary Kay Washington Ruth Sullivan Jamey P Weichert Richard B Halberg

PLoS One 2013 9;8(4):e60709. Epub 2013 Apr 9.

Division of Hematology and Oncology, Department of Medicine, University of Wisconsin, Madison, Wisconsin, United States of America.

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October 2013

A phase I study of sorafenib, oxaliplatin and 2 days of high dose capecitabine in advanced pancreatic and biliary tract cancer: a Wisconsin oncology network study.

Authors:

Noelle K LoConte Kyle D Holen William R Schelman Daniel L Mulkerin Dustin A Deming Hilary R Hernan Anne M Traynor Timothy Goggins David Groteluschen Kurt Oettel Emily Robinson Sam J Lubner

Invest New Drugs 2013 Aug 21;31(4):943-8. Epub 2012 Dec 21.

University of Wisconsin Carbone Cancer Center and the University of Wisconsin School of Medicine and Public Health, 600 Highland Avenue, K6/548 CSC, Madison, WI 53792, USA.

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August 2013