Publications by authors named "Durazzi Federico"

2 Publications

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Antimutagenic and antioxidant activities of some bioflavours from wine.

Food Chem Toxicol 2013 Oct 24;60:141-6. Epub 2013 Jul 24.

Department of Physiology and Pharmacology "V. Erspamer", Sapienza University of Rome, P.le Aldo Moro 5, 00185 Rome, Italy. Electronic address:

Monoterpenes limonene and its metabolic derivatives, α-terpineol and 1,8-cineol, commonly found as aroma wine components, were studied for their antimutagenicity by the bacterial reverse mutation assay on different strains. Substances were also tested for their antioxidant activity, i.e. radical scavenger, chelation, reduction, and lipid peroxidation inhibition. Limonene and its metabolites, α-terpineol and 1,8-cineol, resulted able to inhibit the chemically-induced mutagenesis, although with a different specificity. The antimutagenicity of limonene has been generally retained by its metabolites and sometimes increased. In particular, α-terpineol exhibited the strongest inhibition, moreover it showed to be a remarkable ferrous ions chelating agent. Limonene and 1,8-cineol were devoid of antioxidant activity. Present results are a starting point in evaluating the potential of α-terpineol as a chemopreventive agent and suggest potential functional dietary benefits of wine.
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http://dx.doi.org/10.1016/j.fct.2013.07.042DOI Listing
October 2013

Chelidonium majus L. does not potentiate the hepatic effect of acetaminophen.

Exp Toxicol Pathol 2013 Nov 29;65(7-8):1117-20. Epub 2013 May 29.

Department of Physiology and Pharmacology "V. Erspamer", Sapienza University of Rome, P.le Aldo Moro, 5, 00185 Rome, Italy.

Aim: The present study assessed the ability of Chelidonium majus to potentiate the hepatic effect of a sub-toxic dose of acetaminophen, in rats.

Results: C. majus, when administered alone, did not alter the liver function parameters in male, whereas an increase in fibrinogen level was found in female rats. Moreover, it did not affect the hepatic histomorphology in both male and female rats. The sub-toxic dose of acetaminophen induced: a significant increase in activated partial thromboplastin time in both genders, a focal hepatocellular necrosis with minor lymphocytes infiltrate and a slight but significant increase in total bilirubin, AST, and ALT in male rats, and in prothrombin time in female rats. The co-administration of C. majus did not increase the effects induced by acetaminophen, in both genders.

Conclusions: C. majus does not modify the hepatic effects of acetaminophen in our in vivo experimental model.
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http://dx.doi.org/10.1016/j.etp.2013.05.002DOI Listing
November 2013