Publications by authors named "Duo Li"

419 Publications

Neuroprotective Effects and Mechanisms of Procyanidins In Vitro and In Vivo.

Molecules 2021 May 17;26(10). Epub 2021 May 17.

Department of Food Science and Nutrition, Zhejiang University, Hangzhou 310000, China.

This study evaluated the neuroprotective effects and mechanisms of procyanidins (PCs). In vitro, rat pheochromocytoma cells (PC12 cells) were exposed to PCs (1, 2 or 4 μg/mL) or N-Acetyl-L-cysteine (NAC) (20 μM) for 24 h, and then incubated with 200 μM of HO for 24 h. Compared with HO alone, PCs significantly increased antioxidant activities (e.g., glutathione peroxidase (GSH-Px), superoxide dismutase (SOD), catalase (CAT)), decreased levels of reactive oxygen species (ROS) and malondialdehyde (MDA), and increased nuclear factor-erythroid 2-related factor 2 (Nrf2) accumulation and increased the expression of quinone oxidoreductase 1 (NQO1), heme oxygenase 1 (HO-1), glutamate-cysteine ligase modifier subunit (GCLM), and glutamate-cysteine ligase catalytic subunit (GCLC). In vivo, zebrafish larvae (AB strain) 3 days post-fertilization (dpf) were exposed to NAC (30 μM) or PCs (4, 8 or 16 μg/mL) in the absence or presence of 300 μM of HO for 4 days. Compared with HO alone, PCs enhanced antioxidant activities (e.g., GSH-Px, CAT, and SOD), decreased levels of ROS and MDA, and enhanced Nrf2/ antioxidant response element (ARE) activation and raised expression levels of NQO1, HO-1, GCLM, and GCLC. In conclusion, these results indicated that PCs exerted neuroprotective effects via activating the Nrf2/ARE pathway and alleviating oxidative damage.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3390/molecules26102963DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8155916PMC
May 2021

Anti-Septic Potential of 7-α-Obacunyl Acetate Isolated from the on Cecal Ligation/Puncture Mice via Suppression of JAK-STAT/NF-κB Signal Pathway.

Infect Drug Resist 2021 14;14:1813-1821. Epub 2021 May 14.

Department of Critical Care Medicine, Beijing Luhe Hospital, Capital Medical University, Beijing, 101149, People's Republic of China.

Purpose: Sepsis is a life-threatening clinical syndrome and characterized by an inflammatory and innate immune response to infections. The current study was aimed to evaluate the anti-sepsis effect of 7-α-Obacunyl acetate (7-OBA), the abundant constituent isolated from (Meliaceae), in cecal ligation and puncture (CLP)-induced mice and to investigate the related molecular mechanisms.

Methods: The CLP operation was performed to establish the sepsis mice model, and the survival rate and temperature were measured after 7-OBA treatment (7.5, 15, and 30 mg/kg; i.p.). Inflammatory cytokines levels of TNF-α, IL-1β, IL-6, and IL-10 were detected by ELISA kits, and the kidney, liver, and heart function were measured using an automatic biochemistry analyzer. Effects of 7-OBA on NF-κB and JAK2-STAT3 signaling pathways were determined by Western blot analysis in a lipopolysaccharide (LPS) stimulated RAW264.7 cells model.

Results: 7-OBA treatment significantly increased the survival rate (<0.05 and <0.01) and normalized temperature (<0.05 and <0.01) of sepsis mice. The levels of pro-inflammatory cytokines like TNF-α, IL-1β, and IL-6 in serum were obviously decreased, whereas the anti-inflammatory cytokines of IL-10 were increased. CLP-induced increases of the main markers of kidney, liver, and heart function in mice (<0.01) were also obviously reversed by 7-OBA. The anti-sepsis effect of 7-OBA might be associated with regulation of nuclear factor kappa-B (NF-κB) and Janus kinase 2 (JAK2)-signal transducer and activator of transcription 3 (STAT3) signal pathways.

Conclusion: Our investigation indicated that 7-OBA can be developed as an effective agent for treating/curing sepsis in the future.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.2147/IDR.S302853DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8131011PMC
May 2021

Three-dimensional MoS nanoflowers supported Prussian blue and Au nanoparticles: A peroxidase-mimicking catalyst for the colorimetric detection of hydrogen peroxide and glucose.

Spectrochim Acta A Mol Biomol Spectrosc 2021 Oct 30;259:119886. Epub 2021 Apr 30.

Life and Health Research Institute, Tianjin Key Laboratory of Organic Solar Cells and photochemical Conversion, School of Chemistry & Chemical Engineering, Tianjin University of Technology, Tianjin 300384, PR China. Electronic address:

Well-dispersed Prussian blue (PB) and Au nanoparticles (Au NPs) loaded three dimensional MoS nanoflowers ([email protected] NFs) was synthesized by a simple and economical method. The structure, morphology and composition of the hybrid were characterized by XRD, SEM and EDS. Similar to the reported literature, MoS nanoflowers showed peroxidase-like activity in catalyzing the oxidation of 3,3',5,5'-tetramethylbenzidine (TMB). This peroxidase-mimicking activity could be enhanced with the introduction of PB and Au NPs. Herein, [email protected] NFs could be used to establish a new platform for the determination of HO and glucose by the chromogenic reaction. Wide linear ranges with 0-15 μM and 0-120 μM for HO and glucose detection were finally obtained. The detection limits were as low as 0.25 μM and 3 μM (with signal to noise ratio of 3), respectively. The established platform was also used successfully for the determination of glucose in human serum and fruit juice samples with excellent sensitivity and stability.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.saa.2021.119886DOI Listing
October 2021

Metagenomic analysis reveals oropharyngeal microbiota alterations in patients with COVID-19.

Signal Transduct Target Ther 2021 05 13;6(1):191. Epub 2021 May 13.

School of Life Science and Technology, Harbin Institute of Technology, Harbin, China.

COVID-19 remains a serious emerging global health problem, and little is known about the role of oropharynx commensal microbes in infection susceptibility and severity. Here, we present the oropharyngeal microbiota characteristics identified by shotgun metagenomic sequencing analyses of oropharynx swab specimens from 31 COVID-19 patients, 29 influenza B patients, and 28 healthy controls. Our results revealed a distinct oropharyngeal microbiota composition in the COVID-19 patients, characterized by enrichment of opportunistic pathogens such as Veillonella and Megasphaera and depletion of Pseudopropionibacterium, Rothia, and Streptococcus. Based on the relative abundance of the oropharyngeal microbiome, we built a microbial classifier to distinguish COVID-19 patients from flu patients and healthy controls with an AUC of 0.889, in which Veillonella was identified as the most prominent biomarker for COVID-19 group. Several members of the genus Veillonella, especially Veillonella parvula which was highly enriched in the oropharynx of our COVID-19 patients, were also overrepresented in the BALF of COVID-19 patients, indicating that the oral cavity acts as a natural reservoir for pathogens to induce co-infections in the lungs of COVID-19 patients. We also found the increased ratios of Klebsiella sp., Acinetobacter sp., and Serratia sp. were correlated with both disease severity and elevated systemic inflammation markers (neutrophil-lymphocyte ratio, NLR), suggesting that these oropharynx microbiota alterations may impact COVID-19 severity by influencing the inflammatory response. Moreover, the oropharyngeal microbiome of COVID-19 patients exhibited a significant enrichment in amino acid metabolism and xenobiotic biodegradation and metabolism. In addition, all 26 drug classes of antimicrobial resistance genes were detected in the COVID-19 group, and were significantly enriched in critical cases. In conclusion, we found that oropharyngeal microbiota alterations and functional differences were associated with COVID-19 severity.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41392-021-00614-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8116522PMC
May 2021

Freeform surface generation by atmospheric pressure plasma processing using a time-variant influence function.

Opt Express 2021 Apr;29(8):11479-11493

Based on a controllable chemical reaction, atmospheric pressure plasma processing (APPP) can achieve efficient material removal even when the tool influence function (TIF) size is reduced to several millimeters, resulting in its great application potential for generating freeform surfaces. However, the TIF changes with the local dwell time, introducing nonlinearity into processing, because of the influence of the plasma thermal effect on chemical reactions. In this paper, a freeform generation method using a time-variant TIF is presented and validated. First, the time-variant removal characteristics of APPP and its nonlinear influence on freeform surface generation are analyzed. Then, the freeform surface generation concept is proposed based on controlling the local volumetric removal. Consequently, the dwell time calculation method is developed to suppress the nonlinearity induced by the time-variant TIF. Finally, the developed method is evaluated by the simulation and experimental analysis of the complex structure generation process. Results show that the proposed method can reduce the nonlinear influence of the time-variant TIF by reasonably calculating dwell time, promoting the application of APPP in freeform surface generation.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1364/OE.421688DOI Listing
April 2021

Role of clinicopathological features for the early prediction of prognosis in lupus nephritis.

Immunol Res 2021 May 5. Epub 2021 May 5.

Department of Nephrology, the First Affiliated Hospital of Wenzhou Medical University, Nanbaixiang Street, Ouhai District, Wenzhou, Zhejiang, 325000, People's Republic of China.

Ambiguities remain regarding the role of clinicopathological characteristics in the early prediction of the prognosis of lupus nephritis (LN). Systemic lupus erythematosus (SLE) patients who completed routine follow-up were identified and retrospectively reviewed for eligible cases. Poor prognosis was defined as all-cause mortality or a persistent decrease of eGFR greater than half the baseline level or progression to end-stage renal disease (ESRD). An optimal Cox regression model was constructed for the early prediction of a poor prognosis for LN. Among the 2163 SLE patients, 376 eligible LN cases were enrolled in the study, with a median follow-up time of 55 [27.0, 87.0] months. The male-to-female ratio was 1:7.2, and 37 patients (9.8%) progressed to the composite endpoint. The ISN/RPS class was significantly associated with proteinuria levels (P-value < 0.001), and class IV/IV + V patients, but not class V patients, had the most severe proteinuria. Our optimal multivariate Cox regression model indicated that sex, ISN/RPS class, tubular atrophy/interstitial fibrosis, serum albumin, tertiles of proteinuria, and their interaction were independently associated with a poor prognosis. ROC analysis and external validation demonstrated that our model was efficient and robust for distinguishing LN patients with a poor prognosis. Our study constructed a robust and early predictive model for convenience in clinical practice to identify poor prognosis in LN patients. We found a significant interaction effect between proteinuria and serum albumin for the prediction of poor prognosis. LN patients with low-level proteinuria and hypoalbuminemia exhibit an increased hazard of progression to poor outcomes.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12026-021-09201-8DOI Listing
May 2021

Undocumented Migrants Reintroducing COVID-19, Yunnan Province, China.

Emerg Infect Dis 2021 ;27(5):1543-1545

To limit the spread of severe acute respiratory syndrome coronavirus 2, the government of China has been monitoring infected travelers and minimizing cold-chain contamination. However, other factors might contribute to recurring outbreaks. We analyze the role of undocumented migrants as potential transmitters of severe acute respiratory syndrome coronavirus 2 in China.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3201/eid2705.204944DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8084479PMC
January 2021

Palmitoleic Acid Protects against Hypertension by Inhibiting NF-κB-Mediated Inflammation.

Mol Nutr Food Res 2021 Apr 17:e2001025. Epub 2021 Apr 17.

Department of Food Science and Nutrition, Zhejiang University, Hangzhou, China.

Scope: The role of palmitoleic acid (POA) in hypertension or blood pressure remains uncertain. This study aims to investigate the epidemiological association between circulating POA and primary hypertension in humans, and subsequently evaluate the effects of exogenous POA on blood pressure and aortic remodeling in spontaneously hypertensive rats (SHRs).

Methods And Results: A case-control study of 349 hypertensive and 1396 normotensive children and adolescents is conducted, and found hypertensive cases show significant lower erythrocyte phospholipid POA than normotensive controls (p < 0.001). In conditional logistic regression model, participants in the top quartile of POA have a lower prevalence of primary hypertension than those in the bottom (multivariate-adjusted OR: 0.47, 95% CI: 0.25-0.89). In animal study, 24 SHRs are randomly assigned to n-3 PUFAs (500 mg kg ), POA (500 mg kg ), or vehicle (olive oil) for 8 weeks. At the end of intervention, as compared to SHRs treated with vehicle, SHRs treated with POA shows significantly decreased systolic blood pressure (SBP), improved aortic remodeling, and also decreased aortic expressions of NF-κB and its downstream proinflammatory cytokines.

Conclusions: Circulating POA is inversely associated with risk of primary hypertension, and exogenous POA supplementation can decrease SBP and improve aortic remodeling by inhibiting NF-κB-mediated inflammation.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1002/mnfr.202001025DOI Listing
April 2021

Modulation of the Corticomotor Excitability by Repetitive Peripheral Magnetic Stimulation on the Median Nerve in Healthy Subjects.

Front Neural Circuits 2021 18;15:616084. Epub 2021 Mar 18.

Department of Sport Rehabilitation, Shanghai University of Sport, Shanghai, China.

We aimed to examine the effects of repetitive peripheral nerve magnetic stimulation (rPNMS) on the excitability of the contralateral motor cortex and motor function of the upper limb in healthy subjects. Forty-six healthy subjects were randomly assigned to either a repetitive peripheral nerve magnetic stimulation group ( = 23) or a sham group ( = 23). The repetitive peripheral nerve magnetic stimulation group received stimulation using magnetic pulses at 20 Hz, which were applied on the median nerve of the non-dominant hand, whereas the sham group underwent the same protocol without the stimulation output. The primary outcome was contralateral transcranial magnetic stimulation (TMS)-induced corticomotor excitability for the abductor pollicis brevis of the stimulated hand in terms of resting motor threshold (rMT), the slope of recruitment curve, and peak amplitude of motor evoked potential (MEP), which were measured at baseline and immediately after each session. The secondary outcomes were motor hand function including dexterity and grip strength of the non-dominant hand assessed at baseline, immediately after stimulation, and 24 h post-stimulation. Compared with the sham stimulation, repetitive peripheral nerve magnetic stimulation increased the peak motor evoked potential amplitude immediately after the intervention. The repetitive peripheral nerve magnetic stimulation also increased the slope of the recruitment curve immediately after intervention and enhanced hand dexterity after 24 h. However, the between-group difference for the changes was not significant. The significant changes in hand dexterity and peak amplitude of motor evoked potential after repetitive peripheral nerve magnetic stimulation were associated with their baseline value. Repetitive peripheral nerve magnetic stimulation may modulate the corticomotor excitability together with a possible lasting improvement in hand dexterity, indicating that it might be helpful for clinical rehabilitation.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3389/fncir.2021.616084DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8012681PMC
March 2021

Cascadia megathrust earthquake rupture model constrained by geodetic fault locking.

Authors:
Duo Li Yajing Liu

Philos Trans A Math Phys Eng Sci 2021 May 15;379(2196):20200135. Epub 2021 Mar 15.

Department of Earth and Planetary Sciences McGill University, 3450 University Street, Montréal, Québec, Canada.

Paleo-earthquakes along the Cascadia subduction zone inferred from offshore sediments and Japan coastal tsunami deposits approximated to M9+ and ruptured the entire margin. However, due to the lack of modern megathrust earthquake records and general quiescence of subduction fault seismicity, the potential megathrust rupture scenario and influence of downdip limit of the seismogenic zone are still obscure. In this study, we present a numerical simulation of Cascadia subduction zone earthquake sequences in the laboratory-derived rate-and-state friction framework to investigate the potential influence of the geodetic fault locking on the megathrust sequences. We consider the rate-state friction stability parameter constrained by geodetic fault locking models derived from decadal GPS records, tidal gauge and levelling-derived uplift rate data along the Cascadia margin. We incorporate historical coseismic subsidence inferred from coastal marine sediments to validate our coseismic rupture scenarios. Earthquake rupture pattern is strongly controlled by the downdip width of the seismogenic, velocity-weakening zone and by the earthquake nucleation zone size. In our model, along-strike heterogeneous characteristic slip distance is required to generate margin-wide ruptures that result in reasonable agreement between the synthetic and observed coastal subsidence for the AD 1700 Cascadia Mw∼9.0 megathrust rupture. Our results suggest the geodetically inferred fault locking model can provide a useful constraint on earthquake rupture scenarios in subduction zones. This article is part of the theme issue 'Fracture dynamics of solid materials: from particles to the globe'.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1098/rsta.2020.0135DOI Listing
May 2021

An optimization method coupled the index-overlay method with entropy weighting model to assess seawater intrusion vulnerability.

Environ Sci Pollut Res Int 2021 Mar 8. Epub 2021 Mar 8.

Hebei Key Laboratory of Geological Resources and Environment Monitoring and Protection, Shijiazhuang, 050021, China.

Seawater intrusion poses a serious threat to coastal areas around the world. The purpose of this study was to develop a comprehensive approach to assess the vulnerability of saltwater intrusion. The powerful decision-making technique GALDIT was firstly selected, and its inherent weights are the origin of the subjective method. The entropy method was then integrated to reasonably determine the objective weight of this basic structure. Furthermore, to balance conflicts between subjective and objective methods, game theory was intruded upon. The result of the sensitivity analysis showed a correlation coefficient between the effective weights and theoretical weights of the normal method, entropy theory, and game theory of 0.66, 0.89, and 0.94, respectively. Meanwhile, the best correlation coefficient between the vulnerability indices and the values of 38 monitoring wells was obtained by the game model. Finally, the optimal weights of G, A, L, D, I, and T were 0.096, 0.153, 0.220, 0.320, 0.150, and 0.061, respectively. The study area was finally classified into regions with high, moderate, and low vulnerability, accounting for 11.4%, 24.9%, and 63.7% of the area. The paper included that the optimization of GALDIT through game theory gives a more accurate assessment of the groundwater vulnerability to seawater intrusion.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11356-021-13229-6DOI Listing
March 2021

Silencing of peroxiredoxin 1 expression ameliorates ulcerative colitis in a rat model.

J Int Med Res 2021 Mar;49(3):300060520986313

Department of Gastroenterology, The First Affiliated Hospital of Hebei North University, Zhangjiakou, Hebei, China.

Background: Peroxiredoxin 1 (PRDX1), a protein with anti-inflammatory and anti-apoptotic properties, shows elevated expression in ulcerative colitis (UC). However, PRDX1's specific role in UC is poorly understood.

Methods: UC was induced in rats using dextran sulfate sodium (DSS). RNA interference was used to silence the PRDX1 expression. PRDX1 expression levels and the inflammatory cytokines tumor necrosis factor (TNF)-α, interleukin (IL)-1β, IL-6, transforming growth factor (TGF)-β and interferon (IFN)-γ in tissues were assessed by real-time quantitative polymerase chain reaction and western blotting. Colonic injury was assessed by hematoxylin-eosin staining. ELISA was used to assess levels of the inflammatory cytokines TNF-α, IL-1β and IL-6 in colon tissues. Apoptosis of intestinal epithelial cells was assessed by terminal deoxynucleotidyl transferase dUTP nick end labeling, and expression of the apoptotic proteins bcl-2, Bax, cleaved caspase-3 and caspase-3 was assessed by western blotting.

Results: PRDX1 expression was significantly increased in rats with DSS-induced UC. Silencing of PRDX1 expression improved colon injury in rats with DSS-induced UC. In addition, silencing of PRDX1 expression inhibited inflammatory responses and apoptosis of intestinal epithelial cells in rats with DSS-induced UC.

Conclusions: Silencing of PRDX1 expression can ameliorate colon injury in rats with DSS-induced UC.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1177/0300060520986313DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7944532PMC
March 2021

Effects of brown seaweed polyphenols, a class of phlorotannins, on metabolic disorders via regulation of fat function.

Food Funct 2021 Mar 1;12(6):2378-2388. Epub 2021 Mar 1.

Institute of Nutrition & Health, Qingdao University, Qingdao, China.

It is well known that fat dysfunction is the main driver of development of metabolic disorders. Changes in diet and lifestyle are particularly important to reverse the current global rise in obesity-related metabolic disorders. Seaweed has been consumed for thousands of years, and it is rich in bioactive compounds, especially unique polyphenols. The aim of the present review is to summarize the effects of different seaweed polyphenols on fat function in metabolic disorders and the related mechanisms. Seaweed polyphenols activate white adipose tissue to "brown" or "beige" adipose tissue to enhance energy consumption. In addition, the amelioration of fat factor imbalance and inflammatory response is also considered as an important reason for the regulation of lipid function with seaweed polyphenols. The present review provides an important basis for using seaweed polyphenols as potential dietary supplements to prevent metabolic disorders.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1039/d0fo02886jDOI Listing
March 2021

Effect of a genetically engineered interferon-alpha versus traditional interferon-alpha in the treatment of moderate-to-severe COVID-19: a randomised clinical trial.

Ann Med 2021 12;53(1):391-401

Department of Thoracic Surgery, West China Hospital, Sichuan University, Chengdu, China.

Background: There are few effective therapies for coronavirus disease 2019 (COVID-19) upon the outbreak of the pandemic. To compare the effectiveness of a novel genetically engineered recombinant super-compound interferon (rSIFN-co) with traditional interferon-alpha added to baseline antiviral agents (lopinavir-ritonavir or umifenovir) for the treatment of moderate-to-severe COVID-19.

Method: In this multicenter randomized (1:1) trial, patients hospitalized with moderate-to-severe COVID-19 received either rSIFN-co nebulization or interferon-alpha nebulization added to baseline antiviral agents for no more than 28 days. The primary endpoint was the time to clinical improvement. Secondary endpoints included the overall rate of clinical improvement assessed on day 28, the time to radiological improvement and virus nucleic acid negative conversion.

Results: A total of 94 patients were included in the safety set (46 patients assigned to rSIFN-co group, 48 to interferon-alpha group). The time to clinical improvement was 11.5 days versus 14.0 days (95% CI 1.10 to 2.81,  = .019); the overall rate of clinical improvement on day 28 was 93.5% versus 77.1% (difference, 16.4%; 95% CI 3% to 30%); the time to radiological improvement was 8.0 days versus 10.0 days ( = .002), the time to virus nucleic acid negative conversion was 7.0 days versus 10.0 days ( = .018) in the rSIFN-co and interferon alpha arms, respectively. Adverse events were balanced with no deaths among groups.

Conclusions And Relevance: rSIFN-co was associated with a shorter time of clinical improvement than traditional interferon-alpha in the treatment of moderate-to-severe COVID-19 when combined with baseline antiviral agents. rSIFN-co therapy alone or combined with other antiviral therapy is worth to be further studied.Key messagesThere are few effective therapies for coronavirus disease 2019 (COVID-19) upon the outbreak of the pandemic. Interferon alphas, by inducing both innate and adaptive immune responses, have shown clinical efficacy in treating severe acute respiratory syndrome coronavirus and Middle East respiratory syndrome coronavirus.In this multicenter, head-to-head, randomized, clinical trial which included 94 participants with moderate-to-severe COVID-19, the rSIFN-co plus antiviral agents (lopinavir-ritonavir or umifenovir) was associated with a shorter time of clinical improvement than interferon-alpha plus antiviral agents.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1080/07853890.2021.1890329DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7906612PMC
December 2021

Sandalwood seed oil ameliorates hepatic insulin resistance by regulating the JNK/NF-κB inflammatory and PI3K/AKT insulin signaling pathways.

Food Funct 2021 Mar;12(5):2312-2322

Institute of Nutrition & Health, College of Public Health, Qingdao University, Qingdao, China. and Department of Food Science and Nutrition, Zhejiang University, Hangzhou, China.

Sandalwood (santalum spicatum) seed oil (SSO) is rich in ximenynic acid. The aim of the present study was to investigate the effect of SSO on high-fat/high-sucrose diet (HFHSD) induced insulin resistance (IR) in comparison with fish oil (FO), sunflower oil (SO) and linseed oil (LO). Fifty male Sprague-Dawley rats were randomly divided into five dietary groups: standard chow diet (controls), HFHSD plus 7% SSO, HFHSD plus 7% FO, HFHSD plus 7% SO and HFHSD plus 7% LO. After 12 weeks of feeding, the rats were sacrificed, and the serum parameters, hepatic lipids and underlying molecular mechanisms were studied. SSO, FO or LO significantly prevented glucose intolerance, hyperglycaemia, obesity, and hepatic lipid accumulation, and decreased the homeostasis model assessment of IR (HOMA-IR) and the serum levels of pro-inflammatory factors (IL-6, IL-1β and TNF-α) compared with SO. In addition, SSO activated the PI3K/AKT insulin signaling pathway and down-regulated the JNK/NF-κB inflammatory signaling pathway in the liver. In summary, our results proved that SSO exerted an ameliorative effect on IR by regulating the hepatic inflammation related blockage of the insulin signaling pathway in the rats.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1039/d0fo03051aDOI Listing
March 2021

Sex-dependent modulation of immune development in mice by secretory IgA-coated Lactobacillus reuteri isolated from breast milk.

J Dairy Sci 2021 Apr 19;104(4):3863-3875. Epub 2021 Feb 19.

Institute of Nutrition and Health, Qingdao University, Qingdao 266071, PR China. Electronic address:

Lactobacilli, commonly present in human breast milk, appear to colonize the neonatal gut and provide protection to infants against various infections, thereby promoting immune development. This study examined the potential probiotic role of breast milk-derived Lactobacillus reuteri FN041 in immune development in mice. The FN041 were gavaged either to BALB/c dams (n = 6/group) during the lactation period or to their offspring (n = 6/sex per intervention) after weaning separately (cointervention). All interventions induced increased intestinal barriers in 5-wk-old offspring, especially in the females. Immunoglobulin A plasmocytes in ileal tissue and secretory IgA (sIgA) in ileal contents increased in all 5-wk-old offspring of cointervention. The activation of mRNA expression of 17 genes was sex-dependent, especially in 5-wk-old offspring. Broader genes were regulated in female mice. The effect of cointervention on the Shannon index of total microbiota is sex-related. The Shannon index of sIgA-coated microbiota increased in both sexes. The sIgA-coated microbiota showed intergroup differences according to β diversity, especially in female mice that showed an increase in Bifidobacterium of Actinobacteria. The sIgA-coated Bifidobacterium was positively correlated with mRNA expression of Tlr9. The sIgA-coated Lactobacillus in male offspring was negatively correlated with mRNA expression of Cldn2. In conclusion, L. reuteri FN041 promoted the production of intestinal sIgA and the expression of genes related to antimicrobial peptides in the offspring and enhanced the function of the mucosal barrier, depending on sex and treatment manner.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3168/jds.2020-19437DOI Listing
April 2021

Elimination of Multidrug-Resistant Bacteria by Transition Metal Dichalcogenides Encapsulated by Synthetic Single-Stranded DNA.

ACS Appl Mater Interfaces 2021 Feb 11;13(7):8082-8094. Epub 2021 Feb 11.

Materials Science and Engineering, School for Engineering of Matter, Transport and Energy, Arizona State University, Tempe, Arizona 85287, United States.

Antibiotic-resistant bacteria are a significant and growing threat to human health. Recently, two-dimensional (2D) nanomaterials have shown antimicrobial activity and have the potential to be used as new approaches to treating antibiotic resistant bacteria. In this Research Article, we exfoliate transition metal dichalcogenide (TMDC) nanosheets using synthetic single-stranded DNA (ssDNA) sequences, and demonstrate the broad-spectrum antibacterial activity of MoSe encapsulated by the T ssDNA sequence in eliminating several multidrug-resistant (MDR) bacteria. The MoSe/T is able to eradicate Gram-positive and Gram-positive at much lower concentrations than graphene-based nanomaterials. Eradication of MDR strains of methicillin-resistant (MRSA), , , , and are shown to occur at at 75 μg mL concentration of MoSe/T, and at 150 μg mL. Molecular dynamics simulations show that the thymine bases in the T sequence lie flat on the MoSe surface and can, thus, form a very good conformal coating and allow the MoSe to act as a sharp nanoknife. Electron microscopy shows the MoSe nanosheets cutting through the cell membranes, resulting in significant cellular damage and the formation of interior voids. Further assays show the change in membrane potential and reactive oxygen species (ROS) formation as mechanisms of antimicrobial activity of MoSe/T. The cellular death pathways are also examined by mRNA expression. This work shows that biocompatible TMDCs, specifically MoSe/T, is a potent antimicrobial agent against MDR bacteria and has potential for clinical settings.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1021/acsami.0c22941DOI Listing
February 2021

Brain decoding in multiple languages: Can cross-language brain decoding work?

Authors:
Min Xu Duo Li Ping Li

Brain Lang 2021 Apr 5;215:104922. Epub 2021 Feb 5.

Department of Chinese and Bilingual Studies, Faculty of Humanities, The Hong Kong Polytechnic University, Kowloon, Hong Kong, China. Electronic address:

The approach of cross-language brain decoding is to use models of brain decoding from one language to decode stimuli of another language. It has the potential to provide new insights into how our brain represents multiple languages. While it is possible to decode semantic information across different languages from neuroimaging data, the approach's overall success remains to be tested and depends on a number of factors such as cross-language similarity, age of acquisition/proficiency levels, and depth of language processing. We expect to see continued progress in this domain, from a traditional focus on words and concrete concepts toward the use of naturalistic experimental tasks involving higher-level language processing (e.g., discourse processing). The approach can also be applied to understand how cross-modal, cross-cultural, and other nonlinguistic factors may influence neural representations of different languages. This article provides an overview of cross-language brain decoding with suggestions for future research directions.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bandl.2021.104922DOI Listing
April 2021

Effect of different phosphatidylcholines on high fat diet-induced insulin resistance in mice.

Food Funct 2021 Mar;12(4):1516-1528

Institute of Nutrition & Health, College of Public Health, Qingdao University, No. 308 Ningxia Road, Qingdao 266071, China.

Phosphatidylcholine (PC) is the most abundant phospholipid in natural products and exhibits various bioactivities in vivo. However, the beneficial effects of PC on IR and the potential mechanisms are rarely reported. PCs from different biological sources vary greatly in their fatty acid compositions. The present study aimed to investigate the effect of EPA/DHA-PC derived from Sthenototeuthis oualaniensis on high fat diet (HFD)-induced IR in comparison with terrestrial soybean PC (Soy-PC) and egg yolk PC (Egg-PC) in C57BL/6J mice. The results indicated that EPA/DHA-PC, but not Soy-PC or Egg-PC, reversed HFD-induced obesity, IR and hyperglycemia. This improvement was accompanied by enhanced IRS/PI3K/AKT insulin signaling pathway in peripheral tissue, ameliorated JNK and NF-κB inflammatory pathway in white adipose tissue, and changes in the gut microbial composition. Microbiological analysis showed that EPA/DHA-PC treatment prevented the loss of Bacteroidetes, Verrucomicrobia, Akkermansia, Coriobacteriaceae_UCG-002, Lactobacillus, Clostridium_sensu_stricto_1, Bacteroides and inhibited the increase of Firmicutes, Actinobacteria, Proteobacteria, and Ileibacterium. The gut microbiota-derived metabolites LPS and TMAO were also reduced by EPA/DHA-PC. In summary, the improvement effect of PCs on IR is largely related to their fatty acid composition. EPA/DHA-PC prevented IR probably by modulating the gut microbiota composition, ameliorating the chronic inflammation in the adipose tissue and promoting transduction of insulin signaling pathways.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1039/d0fo02632hDOI Listing
March 2021

Effect of n-3 polyunsaturated fatty acid supplementation on muscle mass and function with aging: A meta-analysis of randomized controlled trials.

Prostaglandins Leukot Essent Fatty Acids 2021 02 12;165:102249. Epub 2021 Jan 12.

Institute of Nutrition & Health, Qingdao University, Qingdao, China; School of Public Health, Qingdao University, Qingdao, China. Electronic address:

The results of randomized controlled trials (RCTs) investigating supplemental n-3 polyunsaturated fatty acids (PUFA) on muscle mass and function have been inconsistent. The present study aimed to quantitatively evaluate the effect of n-3 PUFA supplementation on indicators of muscle mass and function in healthy subjects. A systematic literature search was conducted up to July 2020 with databases of PubMed and Web of science. The random-effects model was implemented to calculate the weighted mean difference of net change of indicators regarding muscle mass and function. A total of nine studies (thirteen treatment groups) with 2067 participants were included for data analysis. The summary estimate showed that n-3 PUFA supplementation significantly increased the grip strength (1.17 kg; 95% CI: 0.27, 2.08 kg). Non-significant effect was observed with respect to muscle mass parameters, including fat mass (-0.67 kg; 95% CI: -2.20, 0.87 kg) and lean mass (0.33 kg; 95% CI: -0.35, 1.00 kg). Regarding muscle function indicators, there were non-significant effects on walking speed (-0.01 m•s; 95% CI: -0.03, 0.01 m•s), time up and go test (-0.25 s; 95% CI: -0.55, 0.04 s), respectively. The findings of this study indicated that supplementation with n-3 PUFA might have beneficial effects to improve muscle mass and function in healthy participants. However, there was no significant improvement in the subjects' muscle mass. Whether n-3 PUFA supplementation has favorable effects in participants with sarcopenia are warranted to be further investigated.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.plefa.2021.102249DOI Listing
February 2021

Barcode signal amplifying strategy for sensitive and accurate protein detection on LC-MS/MS.

Analyst 2021 Mar;146(5):1725-1733

State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China.

Protein drugs showing strong pharmaceutical activity, high specificity, and low toxicity and side effects have drawn extensive attention in the field of life sciences and medicine. Precise evaluation of the function of these drugs requires accurate and sensitive detection methods. Here, we report a novel chromatography-tandem mass spectrometry (LC-MS/MS) method for sensitive and selective detection of protein drugs. Magnetic nanoparticles ([email protected]) were functionalized by thrombin aptamers, and quantum dots ([email protected]@QDs) were dual-functionalized with quantitative thrombin aptamers and small molecules with high ionization efficiency as the mass barcode. After [email protected] specifically purify and enrich thrombin from biological samples, they can form a nano "sandwich structure" when [email protected]@QDs are added, resulting in the release of the mass barcode for LC-MS/MS analysis via the cutting of the disulfide bond. Since there is a higher quantitative molecular ratio of mass barcode to thrombin in the nano-"sandwich structure", quantitative detection of thrombin with high sensitivity and selectivity can be achieved via the LC-MS/MS detection of the mass barcode with high ionization efficiency rather than thrombin, which effectively avoids the disadvantages of direct protein detection by mass spectrometry. The established method for thrombin detection shows a good linear relationship in a concentration range of 0.00115-1.15 nM with a limit of detection (LOD) of 0.0007 nM. The present work provides a new approach for the effective and sensitive quantitative analysis of protein drugs and would be of great significance in promoting the development of protein drugs and clinical applications.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1039/d0an01948hDOI Listing
March 2021

Benevolent Creativity Buffers Anxiety Aroused by Mortality Salience: Terror Management in COVID-19 Pandemic.

Front Psychol 2020 29;11:601027. Epub 2020 Dec 29.

Department of Social Psychology, Nankai University, Tianjin, China.

With the outbreak of the COVID-19 crisis, the public keeps getting epidemic-related information on the media. News reports on the increasing number of fatalities have exposed individuals to death, which causes negative emotional experiences such as tension, anxiety, and fear. This study aimed to investigate whether creativity could serve as an anxiety-buffer when mortality is salient. Based on previous findings, the present study utilized type of creative task and personal search for meaning as moderators. In Study 1, a 2 (mortality salience: absent, present) × 2 (type of creative task: benevolent, malevolent) between-subject design was utilized, and 168 subjects were randomly assigned to four experimental conditions. In Study 2, 221 subjects were recruited. The experimental procedure was similar to Study 1, except that the priming paradigm of mortality was changed and search for meaning was included as an additional moderating variable. State anxiety was measured as the dependent variable in both studies. Results of Study 1 showed that, while the benevolent creative task could buffer anxiety in the mortality salience condition, the malevolent creative task did not have the same effect. Furthermore, there was a significant interaction between mortality salience, type of creative task, and search for meaning in life on anxiety. In Study 2, the buffering function of benevolent creativity was more intense for participants with a higher level of search for meaning. Together, these findings reveal the influence of different types of creative tasks on individual anxiety levels under death priming conditions and the moderating effect of search for meaning in this relationship. Further, they suggest the need to focus on the role of creativity in terror management.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3389/fpsyg.2020.601027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7802762PMC
December 2020

Stable Self-Floating Reduced Graphene Oxide Hydrogel Membrane for High Rate of Solar Vapor Evaporation under 1 sun.

Glob Chall 2021 Jan 28;5(1):2000053. Epub 2020 Sep 28.

National Laboratory of Solid State Microstructures College of Engineering and Applied Sciences School of Physics Key Laboratory of Intelligent Optical Sensing and Integration Ministry of Education Nanjing University Nanjing 210093 P. R. China.

Highly efficient vapor generation with considerable stability under natural solar irradiance is a promising technology for seawater desalination and wastewater purification. Here a broadband solar absorber of reduced graphene oxide hydrogel membrane (rGOHM), synthesized via an environmentally friendly one-step hydrothermal reduction process, is demonstrated, which shows a high rate of solar vapor production and superior stability. The porous rGOHM containing more than 99.5% water within its small volume floats on the surface of water, exhibiting efficient solar absorption of 98% across 300-2500 nm, as well as sufficient water-pumping pathways. The evaporation rate can be tuned by changing the water volume. By controlling the water volume, the self-floating rGOHM can enable efficient interfacial solar vapor generation at a high rate of 2.33 kg m h under 1 sun, which is comparable to the rate generated by the evaporator with an extra insulator. In addition, the evaporation rate of rGOHM is only slightly affected at a high saltwater concentration (at least 15 wt%), and the rGOHM shows mechanical and physical stability. The superior evaporation performance combined with efficient eradication of wastewater contaminants, cost-effectiveness, and straightforward fabrication process, makes this rGOHMs ideal for advanced high-concentration seawater desalination and wastewater treatment technologies.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1002/gch2.202000053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7788581PMC
January 2021

Vitamin C mediates the activation of green tea extract to modify nanozero-valent iron composites: Enhanced transport in heterogeneous porous media and the removal of hexavalent chromium.

J Hazard Mater 2021 06 6;411:125042. Epub 2021 Jan 6.

School of Environmental Science and Engineering, Suzhou University of Science and Technology, Suzhou 215009, China; Jiangsu Key Laboratory of Environmental Functional Materials, Suzhou University of Science and Technology, Suzhou 215009, China.

Both green tea (GT) extract and vitamin C (VC) were used for the reduction of Fe to Fe using a green synthesis method. Modified nanozero-valent iron ([email protected] nanocomposites) was successfully obtained and characterized as α-Fe-iron oxide/VC by multiple analytical methods. The [email protected] nanocomposites showed better transportability than nZVI, in that transport behavior was slightly dependent on various ratios of sand/soil in water-saturated heterogeneous porous media. Breakthrough curves of [email protected] nanocomposites in paddy soil exhibited "blocking effects" and were well described using a first-order straining coefficient (k) on site 2 obtained from a two-site kinetic attachment model. In particular, [email protected] (VC/Fe = 0.6) showed higher Cr(VI) removal (especially reducibility) in both paddy soil and water compared to that of nZVI and VC. It is likely that the synergistic effects of VC (ascorbic acid) and tea polyphenols can increase the released free electrons into solution, favoring the high reduction of Cr(VI) into Cr(III) (i.e., FeOCrO, Cr(OH) and CrO), where Cr(III) is prone to be immobilized by the nanocomposites in soil. This research highlights that VC can mediate the activation of GT extract to successfully modify nZVI, which could be beneficial for efficient transport in subsurface and remediation of Cr(VI)-contaminated soil and underground water.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jhazmat.2021.125042DOI Listing
June 2021

Evaluating the Exfoliation Efficiency of Quasi-2D Metal Diboride Nanosheets Using Hansen Solubility Parameters.

Langmuir 2021 Jan 10;37(3):1194-1205. Epub 2021 Jan 10.

Biodesign Center for Molecular Design and Biomimetics, The Biodesign Institute and the School of Molecular Sciences, Arizona State University, Tempe, Arizona 85287, United States.

Non-van der Waals (non-vdW) solids are emerging sources of two-dimensional (2D) nanosheets that can be produced via liquid-phase exfoliation (LPE), and are beginning to expand our understanding of 2D and quasi-2D materials. Recently, nanosheets formed by LPE processing of bulk metal diborides, a diverse family of layered non-vdW ceramic materials, have been reported. However, detailed knowledge of the exfoliation efficiency of these nanomaterials is lacking, and is important for their effective solution-phase processing and for understanding their fundamental surface chemistry, since they have significant differences from more conventional nanosheets produced from layered vdW compounds. Here in this paper we use Hansen solubility theory to investigate nanosheets of the metal borides CrB and MgB derived from LPE. By preparing dispersions in 33 different solvents, we determine Hansen solubility parameters (, , ) for both these metal diborides. We find that they exhibit notably higher and values compared to conventional vdW materials such as graphene and MoS, likely as a result of the types of bonds broken in such materials from exfoliation which allows for more favorable interactions with more polar and hydrogen-bonding solvents. We apply the solubility parameters to identify cosolvent blends suitable for CrB and MgB that produce dispersions with concentrations that match or exceed those of the top-performing individual solvents for each material and that have markedly higher stability compared to the constituent solvents of the blends alone. This work provides insight into the exfoliation effectiveness of different solvents for preparation of nanosheets from metal diborides and non-vdW materials in general. Such knowledge will be crucial for developing liquid-phase exfoliation strategies for incorporating these materials in applications such as nanocomposites, inks, and coatings.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.langmuir.0c03138DOI Listing
January 2021

Econutrition, brown and beige fat tissue and obesity.

Asia Pac J Clin Nutr 2020 ;29(4):668-680

Institute of Nutrition and Health, Qingdao University, Qingdao, China. Email:

Background And Objectives: Obesity is caused by excessive fat accumulation or abnormal fat distribution and has become one of the biggest health challenges worldwide. Considering the high thermogenic ability of brown fat tissue (BAT) and the plasticity of fat tissue, to induce the browning of white fat tissue (WAT), so increasing BAT activity provides an attractive option for the prevention and resolution of obesity. The aim of the present narrative review was to understand the relationship between diet, BAT, and obesity.

Methods And Study Design: PubMed and Embase databases were searched to identify eligible studies.

Results: Although cold exposure has long been known to be effective in the browning of WAT and activation of BAT, it is societally impractical for everyday body weight management aside from the tolerance of ambient temperature. An alternative is to identify specific dietary components with similar effects to cold exposure on BAT. Current evidence indicates that capsaicin and capsinoids, catechins, curcumin, quercetin, berberine, lipoic acid, polyunsaturated fatty acids, royal jelly, and some natural sweeteners are effective promoters of WAT browning, increase BAT activity and improve obesity related traits. However, only capsaicin, capsinoids, and catechins have demonstrated efficacy in clinical trials. Evidence for effects of curcumin, quercetin, berberine, lipoic acid, polyunsaturated fatty acids, royal jelly and natural sweeteners on BAT have only been observed in animal or in vitro studies, with clinical trials awaited for verification.

Conclusions: Several dietary components can induce WAT browning and activate BAT, offering potential targets for obesity prevention and management.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.6133/apjcn.202012_29(4).0001DOI Listing
January 2020

Deoiled sunflower seeds ameliorate depression by promoting the production of monoamine neurotransmitters and inhibiting oxidative stress.

Food Funct 2021 Jan 23;12(2):573-586. Epub 2020 Dec 23.

Institute of Nutrition and Health, School of Public Health, Qingdao University, Qingdao 266071, Shandong, China.

We aimed to evaluate the antidepressant activity of deoiled sunflower seeds (SFS), which are rich in tryptophan, in our mouse model and explored a possible mechanism of action. Male C57BL/6J mice were subjected to chronic unpredictable mild stress (CUMS) and were administered a diet containing SFS as the main protein source. SFS alleviated CUMS-induced depression-like behaviors, compared to the effects of a whey protein-based diet. This effect was related to increases in the levels of serotonin, dopamine, norepinephrine, acetylcholine, and brain-derived neurotrophic factor in SFS-fed mice. These changes accompanied the amelioration of inflammatory abnormalities and oxidative stress. SFS increased the aromatic amino acid levels, and the ratio of tryptophan to neutral amino acids. Furthermore, the antidepressant-like effects of SFS were involved in lipid, nucleotide, and amino acid metabolism. In summary, SFS was found to attenuate depression-like symptoms in mice. These antidepressant effects may be related to the increase in the levels of aromatic amino acids and neurotransmitters, amelioration of oxidative stress and inflammation, and the regulation of the levels of abnormal metabolites to the normal levels.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1039/d0fo01978jDOI Listing
January 2021

Sec-Eliminating the SARS-CoV-2 by AlGaN Based High Power Deep Ultraviolet Light Source.

Adv Funct Mater 2020 Nov 25:2008452. Epub 2020 Nov 25.

State Key Laboratory of Artificial Microstructure and Mesoscopic Physics School of Physics, Nano-Optoelectronics Frontier Center of Ministry of Education (NFC-MOE) Peking University Beijing 100871 China.

The world-wide spreading of coronavirus disease (COVID-19) has greatly shaken human society, thus effective and fast-speed methods of non-daily-life-disturbance sterilization have become extremely significant. In this work, by fully benefitting from high-quality AlN template (with threading dislocation density as low as ≈6×10 cm) as well as outstanding deep ultraviolet (UVC-less than 280 nm) light-emitting diodes (LEDs) structure design and epitaxy optimization, high power UVC LEDs and ultra-high-power sterilization irradiation source are achieved. Moreover, for the first time, a result in which a fast and complete elimination of SARS-CoV-2 (the virus causes COVID-19) within only 1 s is achieved by the nearly whole industry-chain-covered product. These results advance the promising potential in UVC-LED disinfection particularly in the shadow of COVID-19.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1002/adfm.202008452DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7744859PMC
November 2020

Effects of combined calcium and vitamin D supplementation on osteoporosis in postmenopausal women: a systematic review and meta-analysis of randomized controlled trials.

Food Funct 2020 Dec 25;11(12):10817-10827. Epub 2020 Nov 25.

Institute of Nutrition and Health, Qingdao University, Qingdao 266021, China.

Objective: The aim of the present study was to explore whether combined calcium and vitamin D supplementation is beneficial for osteoporosis in postmenopausal women.

Methods: We searched the PubMed, Cochrane library, Web of science and Embase databases and reference lists of eligible articles up to Feb, 2020. Randomized controlled trials (RCTs) evaluating the effect of combined calcium and vitamin D on osteoporosis in postmenopausal women were included in the present study.

Results: Combined calcium and vitamin D significantly increased total bone mineral density (BMD) (standard mean differences (SMD) = 0.537; 95% confidence interval (CI): 0.227 to 0.847), lumbar spine BMD (SMD = 0.233; 95% CI: 0.073 to 0.392; P < 0.001), arms BMD (SMD = 0.464; 95% CI: 0.186 to 0.741) and femoral neck BMD (SMD = 0.187; 95% CI: 0.010 to 0.364). It also significantly reduced the incidence of hip fracture (RR = 0.864; 95% CI: 0.763 to 0.979). Subgroup analysis showed that combined calcium and vitamin D significantly increased femoral neck BMD only when the dose of the vitamin D intake was no more than 400 IU d (SMD = 0.335; 95% CI: 0.113 to 0.558), but not for a dose more than 400 IU d (SMD = -0.098; 95% CI: -0.109 to 0.305), and calcium had no effect on the femoral neck BMD. Subgroup analysis also showed only dairy products fortified with calcium and vitamin D had a significant influence on total BMD (SMD = 0.784; 95% CI: 0.322 to 1.247) and lumbar spine BMD (SMD = 0.320; 95% CI: 0.146 to 0.494), but not for combined calcium and vitamin D supplement.

Conclusion: Dairy products fortified with calcium and vitamin D have a favorable effect on bone mineral density. Combined calcium and vitamin D supplementation could prevent osteoporosis hip fracture in postmenopausal women.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1039/d0fo00787kDOI Listing
December 2020

Scalable and hierarchically designed polymer film as a selective thermal emitter for high-performance all-day radiative cooling.

Nat Nanotechnol 2021 Feb 16;16(2):153-158. Epub 2020 Nov 16.

National Laboratory of Solid State Microstructures, College of Engineering and Applied Sciences, Jiangsu Key Laboratory of Artificial Functional Materials and Collaborative Innovation Center of Advanced Microstructures, Nanjing University, Nanjing, P. R. China.

Traditional cooling systems consume tremendous amounts of energy and thus aggravate the greenhouse effect. Passive radiative cooling, dissipating an object's heat through an atmospheric transparency window (8-13 μm) to outer space without any energy consumption, has attracted much attention. The unique feature of radiative cooling lies in the high emissivity in the atmospheric transparency window through which heat can be dissipated to the universe. Therefore, for achieving high cooling performance, the design and fabrication of selective emitters, with emission strongly dominant in the transparency window, is of essential importance, as such spectral selection suppresses parasitic absorption from the surrounding thermal radiation. Recently, various materials and structures with tailored spectrum responses have been investigated to achieve the effect of daytime radiative cooling. However, most of the radiative cooling materials reported possess broad-band absorption/emission covering the whole mid-infrared wavelength. Here we demonstrate that a hierarchically designed polymer nanofibre-based film, produced by a scalable electrostatic spinning process, enables selective mid-infrared emission, effective sunlight reflection and therefore excellent all-day radiative cooling performance. Specifically, the C-O-C (1,260-1,110 cm) and C-OH (1,239-1,030 cm) bonding endows the selective emissivity of 78% in 8-13 μm wavelength range, and the design of nanofibres with a controlled diameter allows for a high reflectivity of 96.3% in 0.3-2.5 μm wavelength range. As a result, we observe ~3 °C cooling improvement of this selective thermal emitter as compared to that of a non-selective emitter at night, and 5 °C sub-ambient cooling under sunlight. The impact of this hierarchically designed selective thermal emitter on alleviating global warming and temperature regulating an Earth-like planet is also analysed, with a significant advantage demonstrated. With its excellent cooling performance and a scalable process, this hierarchically designed selective thermal emitter opens a new pathway towards large-scale applications of all-day radiative cooling materials.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41565-020-00800-4DOI Listing
February 2021