Publications by authors named "Duncan Sproul"

28Publications

Transition to naïve human pluripotency mirrors pan-cancer DNA hypermethylation.

Nat Commun 2020 07 22;11(1):3671. Epub 2020 Jul 22.

Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, EC1M 6BQ, London, UK.

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http://dx.doi.org/10.1038/s41467-020-17269-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7376100PMC
July 2020

Age-related clonal haemopoiesis is associated with increased epigenetic age.

Curr Biol 2019 08;29(16):R786-R787

MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, EH4 2XU, UK. Electronic address:

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http://dx.doi.org/10.1016/j.cub.2019.07.011DOI Listing
August 2019

Estrogen-induced chromatin decondensation and nuclear re-organization linked to regional epigenetic regulation in breast cancer.

Genome Biol 2015 Aug 3;16:145. Epub 2015 Aug 3.

MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Crewe Road South, Edinburgh, EH4 2XU, UK.

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http://dx.doi.org/10.1186/s13059-015-0719-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4536608PMC
August 2015

Transcription factor binding predicts histone modifications in human cell lines.

Proc Natl Acad Sci U S A 2014 Sep 3;111(37):13367-72. Epub 2014 Sep 3.

Medical Research Council Human Genetics Unit, Medical Research Council Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, United Kingdom; and

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http://dx.doi.org/10.1073/pnas.1412081111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4169916PMC
September 2014

DNA methylation reprogramming in cancer: does it act by re-configuring the binding landscape of Polycomb repressive complexes?

Bioessays 2014 Feb 26;36(2):134-40. Epub 2013 Nov 26.

MRC Human Genetics Unit, MRC IGMM, University of Edinburgh, Edinburgh, United Kingdom.

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http://dx.doi.org/10.1002/bies.201300130DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4225474PMC
February 2014

Expression of a large LINE-1-driven antisense RNA is linked to epigenetic silencing of the metastasis suppressor gene TFPI-2 in cancer.

Nucleic Acids Res 2013 Aug 23;41(14):6857-69. Epub 2013 May 23.

Wolfson Centre for Stem Cells, Tissue Engineering and Modelling (STEM), School of Clinical Sciences, University of Nottingham, Centre for Biomedical Sciences, Nottingham NG7 2RD, UK.

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http://dx.doi.org/10.1093/nar/gkt438DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3737543PMC
August 2013

Targeting of Rac GTPases blocks the spread of intact human breast cancer.

Oncotarget 2012 Jun;3(6):608-19

Breakthrough Breast Cancer Research Unit, University of Edinburgh, Western General Hospital, Edinburgh, United Kingdom.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3442288PMC
http://dx.doi.org/10.18632/oncotarget.520DOI Listing
June 2012

Diversity of matriptase expression level and function in breast cancer.

PLoS One 2012 13;7(4):e34182. Epub 2012 Apr 13.

Edinburgh Cancer Research Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, Scotland, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0034182PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3325989PMC
August 2012

Lactate, a product of glycolytic metabolism, inhibits histone deacetylase activity and promotes changes in gene expression.

Nucleic Acids Res 2012 Jun 9;40(11):4794-803. Epub 2012 Feb 9.

Institute of Genetics and Molecular Medicine, University of Edinburgh, Crewe Road South, Edinburgh, EH4 2XR, SIRCAMS, UK.

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http://dx.doi.org/10.1093/nar/gks066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3367171PMC
June 2012

Tissue type is a major modifier of the 5-hydroxymethylcytosine content of human genes.

Genome Res 2012 Mar 21;22(3):467-77. Epub 2011 Nov 21.

Breakthrough Breast Cancer Research Unit and Division of Pathology, University of Edinburgh, Western General Hospital, Edinburgh, UK.

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http://dx.doi.org/10.1101/gr.126417.111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3290782PMC
March 2012

Modelling genetic and clinical heterogeneity in epithelial ovarian cancers.

Carcinogenesis 2011 Oct 22;32(10):1540-9. Epub 2011 Aug 22.

UCL EGA Institute for Women's Health, University College London, London, UK.

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http://dx.doi.org/10.1093/carcin/bgr140DOI Listing
October 2011

Transcriptionally repressed genes become aberrantly methylated and distinguish tumors of different lineages in breast cancer.

Proc Natl Acad Sci U S A 2011 Mar 28;108(11):4364-9. Epub 2011 Feb 28.

Breakthrough Breast Cancer Research Unit and Edinburgh Cancer Research Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, United Kingdom.

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http://dx.doi.org/10.1073/pnas.1013224108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3060255PMC
March 2011

Recruitment to the nuclear periphery can alter expression of genes in human cells.

PLoS Genet 2008 Mar 21;4(3):e1000039. Epub 2008 Mar 21.

MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom.

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http://dx.doi.org/10.1371/journal.pgen.1000039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2265557PMC
March 2008

The role of chromatin structure in regulating the expression of clustered genes.

Nat Rev Genet 2005 Oct;6(10):775-81

Chromosomes and Gene Expression Section, Medical Research Council Human Genetics Unit, Crewe Road, Edinburgh EH4 2XU, United Kingdom.

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http://hosting.uaa.alaska.edu/afjek/Pages/Uffenbeck.pdf
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http://www.nature.com/doifinder/10.1038/nrg1688
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http://dx.doi.org/10.1038/nrg1688DOI Listing
October 2005

Adenosine deaminases acting on RNA (ADARs): RNA-editing enzymes.

Genome Biol 2004 2;5(2):209. Epub 2004 Feb 2.

Medical Research Council Human Genetics Unit, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK.

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http://genomebiology.biomedcentral.com/articles/10.1186/gb-2
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http://dx.doi.org/10.1186/gb-2004-5-2-209DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC395743PMC
March 2005