Duncan J Stewart

Duncan J Stewart

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Duncan J Stewart

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Thawed Mesenchymal Stem Cell Product Shows Comparable Immunomodulatory Potency to Cultured Cells In Vitro and in Polymicrobial Septic Animals.

Sci Rep 2019 Dec 2;9(1):18078. Epub 2019 Dec 2.

Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, Ontario, K1H 8L6, Canada.

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http://dx.doi.org/10.1038/s41598-019-54462-xDOI Listing
December 2019

Physiologic expansion of human heart-derived cells enhances therapeutic repair of injured myocardium.

Stem Cell Res Ther 2019 Nov 4;10(1):316. Epub 2019 Nov 4.

University of Ottawa Heart Institute, Division of Cardiology, Department of Medicine, University of Ottawa, H3214 40 Ruskin Ave, Ottawa, ON, K1Y4W7, Canada.

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http://dx.doi.org/10.1186/s13287-019-1418-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6829847PMC
November 2019

Systematic Review of MicroRNA Biomarkers in Acute Coronary Syndrome and Stable Coronary Artery Disease.

Cardiovasc Res 2019 Nov 29. Epub 2019 Nov 29.

Centre for Outcomes Research and Evaluation, Research Institute, McGill University Health Centre, Montreal, Canada.

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http://dx.doi.org/10.1093/cvr/cvz302DOI Listing
November 2019

Transcriptomically Guided Mesendoderm Induction of Human Pluripotent Stem Cells Using a Systematically Defined Culture Scheme.

Stem Cell Reports 2019 Nov 20. Epub 2019 Nov 20.

The Sprott Centre for Stem Cell Research, Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada; Ottawa Institute of Systems Biology, Ottawa, ON, Canada; Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON, Canada; Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, ON, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2019.11.001DOI Listing
November 2019

From the Lab to Patients: a Systematic Review and Meta-Analysis of Mesenchymal Stem Cell Therapy for Stroke.

Transl Stroke Res 2019 Oct 25. Epub 2019 Oct 25.

Clinical Epidemiology Program, Blueprint Translational Group, The Ottawa Hospital Research Institute, Ottawa, Canada.

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http://dx.doi.org/10.1007/s12975-019-00736-5DOI Listing
October 2019

Optimizing imaging of the rat pulmonary microvasculature by micro-computed tomography.

Pulm Circ 2019 Oct-Dec;9(4):2045894019883613. Epub 2019 Oct 31.

Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, Canada.

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http://dx.doi.org/10.1177/2045894019883613DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6823983PMC
October 2019

Medical Therapy for Heart Failure Associated With Pulmonary Hypertension.

Circ Res 2019 May;124(11):1551-1567

From the Division of Cardiology, University of Ottawa Heart Institute (J.G.E.Z., L.M.M., D.J.S.), University of Ottawa, Canada.

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https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.118.31365
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http://dx.doi.org/10.1161/CIRCRESAHA.118.313650DOI Listing
May 2019

Myeloid angiogenic cells exhibit impaired migration, reduced expression of endothelial markers, and increased apoptosis in idiopathic pulmonary arterial hypertension .

Can J Physiol Pharmacol 2019 Apr 17;97(4):306-312. Epub 2018 Dec 17.

a Division of Cardiology, Keenan Research Center for Biomedical Science, St. Michael's Hospital, University of Toronto, Toronto, ON M5B 1W8, Canada.

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http://dx.doi.org/10.1139/cjpp-2018-0424DOI Listing
April 2019

Strategies for controlling egress of therapeutic cells from hydrogel microcapsules.

J Tissue Eng Regen Med 2019 04 19;13(4):612-624. Epub 2019 Mar 19.

Department of Physics, University of Ottawa, Ottawa, Ontario, Canada.

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http://dx.doi.org/10.1002/term.2818DOI Listing
April 2019

Regenerative cell therapy for pulmonary arterial hypertension in animal models: a systematic review.

Stem Cell Res Ther 2019 03 6;10(1):75. Epub 2019 Mar 6.

Regenerative Medicine Program, The Ottawa Hospital Research Institute, 501 Smyth Road, PO Box 201B, Ottawa, ON, K1H 8L6, Canada.

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http://dx.doi.org/10.1186/s13287-019-1172-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6404277PMC
March 2019

The Janus Faces of Bone Morphogenetic Protein 9 in Pulmonary Arterial Hypertension.

Circ Res 2019 Mar;124(6):822-824

Ottawa Hospital Research Institute, Sinclair Centre for Regenerative Medicine and the University of Ottawa, Ontario, Canada (R.S.G., K.R.C., D.J.S.).

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http://dx.doi.org/10.1161/CIRCRESAHA.119.314753DOI Listing
March 2019

Increased Expression of Vascular Endothelial Growth Factor-D Following Brain Injury.

Int J Mol Sci 2019 Mar 30;20(7). Epub 2019 Mar 30.

Department of Medicine, University of Ottawa, and Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada.

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http://dx.doi.org/10.3390/ijms20071594DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6479775PMC
March 2019

Systematic Assessment of Strategies for Lung-targeted Delivery of MicroRNA Mimics.

Theranostics 2018 2;8(5):1213-1226. Epub 2018 Feb 2.

Sinclair Centre for Regenerative Medicine, Ottawa Hospital Research Institute, Ottawa, ON, Canada.

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http://dx.doi.org/10.7150/thno.22912DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5835931PMC
January 2019

Circulating MicroRNAs Implicate Multiple Atherogenic Abnormalities in the Long-Term Cardiovascular Sequelae of Preeclampsia.

Am J Hypertens 2018 09;31(10):1093-1097

Department of Medicine, Division of General Internal Medicine, McGill University Health Centre, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1093/ajh/hpy069DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6132124PMC
September 2018

Interleukin-6 Mediates Post-Infarct Repair by Cardiac Explant-Derived Stem Cells.

Theranostics 2017 17;7(19):4850-4861. Epub 2017 Oct 17.

University of Ottawa Heart Institute, Division of Cardiology, Department of Medicine, University of Ottawa, Ottawa, Canada K1Y4W7.

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http://dx.doi.org/10.7150/thno.19435DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5706104PMC
July 2018

Go with the (back) flow: what can retrograde perfusion teach us about arterial remodeling in pulmonary arterial hypertension?

Am J Physiol Lung Cell Mol Physiol 2018 05 8;314(5):L797-L798. Epub 2018 Feb 8.

Sinclair Centre for Regenerative Medicine, Ottawa Hospital Research Institute , Ottawa, Ontario , Canada.

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http://dx.doi.org/10.1152/ajplung.00065.2018DOI Listing
May 2018

Taking the right ventricle to 'task' in pulmonary hypertension: role of TASK1/KCNK3 in RV dysfunction.

Cardiovasc Res 2018 05;114(6):776-778

Sinclair Centre for Regenerative Medicine, Ottawa Hospital Research Institute, 501 Smyth Road, Ottawa, ON K1H 8L6, Canada.

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http://dx.doi.org/10.1093/cvr/cvy066DOI Listing
May 2018

Deterministic Encapsulation of Human Cardiac Stem Cells in Variable Composition Nanoporous Gel Cocoons To Enhance Therapeutic Repair of Injured Myocardium.

ACS Nano 2018 05 20;12(5):4338-4350. Epub 2018 Apr 20.

University of Ottawa Heart Institute, Division of Cardiology, Department of Medicine , University of Ottawa , Ottawa , Canada K1Y4W7.

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http://dx.doi.org/10.1021/acsnano.7b08881DOI Listing
May 2018

High circulating angiopoietin-2 levels exacerbate pulmonary inflammation but not vascular leak or mortality in endotoxin-induced lung injury in mice.

Thorax 2018 03 25;73(3):248-261. Epub 2017 Sep 25.

Regenerative Medicine Program, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Ontario, Canada.

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http://dx.doi.org/10.1136/thoraxjnl-2017-210413DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5870448PMC
March 2018

Clinical Features and Outcomes of Acute Coronary Syndrome in Women With Previous Pregnancy Complications.

Can J Cardiol 2017 12 11;33(12):1683-1692. Epub 2017 Sep 11.

Research Institute, McGill University Health Centre, Montreal, Quebec, Canada; Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Quebec, Canada; Division of General Internal Medicine, McGill University Health Centre, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1016/j.cjca.2017.08.025DOI Listing
December 2017

Systemic delivery of MicroRNA mimics with polyethylenimine elevates pulmonary microRNA levels, but lacks pulmonary selectivity.

Pulm Circ 2018 Jan-Mar;8(1):2045893217750613. Epub 2017 Dec 18.

1 10055 Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada.

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http://dx.doi.org/10.1177/2045893217750613DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5753929PMC
December 2017

Assessment of safety and efficacy of mesenchymal stromal cell therapy in preclinical models of acute myocardial infarction: a systematic review protocol.

Syst Rev 2017 11 7;6(1):226. Epub 2017 Nov 7.

Clinical Epidemiology Program, Ottawa Hospital Research Institute, Department of Medicine (Division of Critical Care), University of Ottawa, 501 Smyth Rd, Box 201, Ottawa, ON, K1H 8L6, Canada.

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http://dx.doi.org/10.1186/s13643-017-0601-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5688817PMC
November 2017

Macro- and micro-heterogeneity of lung endothelial cells: they may not be smooth, but they got the moves.

Pulm Circ 2017 Oct-Dec;7(4):755-757

1 Sinclair Centre for Regenerative Medicine, Ottawa Hospital Research Institute, Ottawa, ON, Canada.

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http://dx.doi.org/10.1177/2045893217743710DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5703129PMC
November 2017

Cardiotrophin 1 stimulates beneficial myogenic and vascular remodeling of the heart.

Cell Res 2017 Oct 8;27(10):1195-1215. Epub 2017 Aug 8.

Sprott Centre for Stem Cell Research, Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa Hospital, Ottawa, Ontario K1H 8L6, Canada.

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http://dx.doi.org/10.1038/cr.2017.87DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5630684PMC
October 2017

Molecular Changes Associated with the Protective Effects of Angiopoietin-1 During Blood-Brain Barrier Breakdown Post-Injury.

Mol Neurobiol 2017 08 22;54(6):4232-4242. Epub 2016 Jun 22.

Ottawa Health Research Institute, University of Ottawa, Ottawa, ON, Canada.

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http://dx.doi.org/10.1007/s12035-016-9973-4DOI Listing
August 2017

Proliferative Versus Degenerative Paradigms in Pulmonary Arterial Hypertension: Have We Put the Cart Before the Horse?

Circ Res 2017 04;120(8):1237-1239

From the Sinclair Center for Regenerative Medicine, Ottawa Hospital Research Institute, Canada (K.R.C., M.T., V.J.J.C., R.S.G., D.J.S.); and Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Canada (K.R.C., M.T., D.J.S.).

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http://dx.doi.org/10.1161/CIRCRESAHA.116.310097DOI Listing
April 2017

Advances in Stem Cell and Cell-Based Gene Therapy Approaches for Experimental Acute Lung Injury: A Review of Preclinical Studies.

Hum Gene Ther 2016 10;27(10):802-812

1 Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.

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http://dx.doi.org/10.1089/hum.2016.063DOI Listing
October 2016

Brief Report: Elastin Microfibril Interface 1 and Integrin-Linked Protein Kinase Are Novel Markers of Islet Regenerative Function in Human Multipotent Mesenchymal Stromal Cells.

Stem Cells 2016 08 19;34(8):2249-55. Epub 2016 May 19.

Regulatory Research Division, Centre for Biologics Evaluation, Biologics and Genetic Therapies Directorate, Health Products and Food Branch, Health Canada, Ottawa, Ontario, Canada.

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http://dx.doi.org/10.1002/stem.2385DOI Listing
August 2016

Paracrine Engineering of Human Explant-Derived Cardiac Stem Cells to Over-Express Stromal-Cell Derived Factor 1α Enhances Myocardial Repair.

Stem Cells 2016 07 21;34(7):1826-35. Epub 2016 Apr 21.

Division of Cardiology, Department of Medicine, University of Ottawa Heart Institute, University of Ottawa, Ottawa, K1Y4W7, Canada.

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http://dx.doi.org/10.1002/stem.2373DOI Listing
July 2016

The impact of patient co-morbidities on the regenerative capacity of cardiac explant-derived stem cells.

Stem Cell Res Ther 2016 May 26;7(1):60. Epub 2016 May 26.

University of Ottawa Heart Institute, Division of Cardiology, Department of Medicine, University of Ottawa, Ottawa, K1Y4W7, Canada.

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http://dx.doi.org/10.1186/s13287-016-0321-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4880978PMC
May 2016

Customized Internal Reference Controls for Improved Assessment of Circulating MicroRNAs in Disease.

PLoS One 2015 26;10(5):e0127443. Epub 2015 May 26.

Regenerative Medicine Program, Ottawa Hospital Research Institute. Ottawa, Ontario, Canada; Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0127443PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4444297PMC
April 2016

Marked Strain-Specific Differences in the SU5416 Rat Model of Severe Pulmonary Arterial Hypertension.

Am J Respir Cell Mol Biol 2016 Apr;54(4):461-8

1 Sinclair Centre for Regenerative Medicine, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada; and.

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http://dx.doi.org/10.1165/rcmb.2014-0488OCDOI Listing
April 2016

Transient Receptor Potential Melastatin 7 Cation Channel Kinase: New Player in Angiotensin II-Induced Hypertension.

Hypertension 2016 Apr 29;67(4):763-73. Epub 2016 Feb 29.

From the Kidney Research Centre (T.T.A., G.E.C., Y.H., A.Y., R.M.T.) and Sprott Centre for Stem Cell Research and Regenerative Medicine Program (A.Z., D.J.S.), Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Canada; Department of Pharmacology, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ (A.G.R., L.V.R.); Department of Physiology and Groupe de Recherche Axé sur la Structure des Protéines, McGill University, Montreal, QC, Canada (A.S.); and BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom (R.M.T.).

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http://circres.ahajournals.org/content/96/2/207.full.pdf
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http://hyper.ahajournals.org/lookup/doi/10.1161/HYPERTENSION
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http://dx.doi.org/10.1161/HYPERTENSIONAHA.115.07021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4786473PMC
April 2016

Occlusive lung arterial lesions in endothelial-targeted, fas-induced apoptosis transgenic mice.

Am J Respir Cell Mol Biol 2015 Nov;53(5):712-8

1 Sinclair Centre for Regenerative Medicine, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.

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http://dx.doi.org/10.1165/rcmb.2014-0311OCDOI Listing
November 2015

The Immunomodulatory and Therapeutic Effects of Mesenchymal Stromal Cells for Acute Lung Injury and Sepsis.

J Cell Physiol 2015 Nov;230(11):2606-17

Sinclair Centre for Regenerative Medicine, Ottawa Hospital Research Institute, Ottawa, Ontario.

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http://dx.doi.org/10.1002/jcp.25028DOI Listing
November 2015

Endothelial NO-Synthase Gene-Enhanced Progenitor Cell Therapy for Pulmonary Arterial Hypertension: The PHACeT Trial.

Circ Res 2015 Sep 20;117(7):645-54. Epub 2015 Jul 20.

From the Division of Respirology, Pulmonary Hypertension Program, University Health Network (J. Granton) and Division of Cardiology, Keenan Research Center for Biomedical Science at the Li Ka Shing Knowledge Institute, St. Michael's Hospital (M.B.K.), Department of Medicine, University of Toronto, Toronto, Ontario, Canada (J. Granton, M.B.K.); Center for Pulmonary Vascular Disease, Division of Cardiology, and Lady Davis Research Institute, Jewish General Hospital, Department of Medicine, McGill University, Montreal, Quebec, Canada (D.L.); Ottawa Hospital Research Institute, Ottawa, Ontario, Canada (N.C., D.W.C., D.J.S.); Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada (D.W.C., D.J.S.); Department of Hematology and Oncology, Winship Cancer Institute, Emory University, Atlanta, GA (J. Galipeau); and Northern Therapeutics, Montreal, Quebec, Canada (D.W.C., D.J.S.).

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https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.114.30595
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http://dx.doi.org/10.1161/CIRCRESAHA.114.305951DOI Listing
September 2015

Paracrine Engineering of Human Cardiac Stem Cells With Insulin-Like Growth Factor 1 Enhances Myocardial Repair.

J Am Heart Assoc 2015 Sep 11;4(9):e002104. Epub 2015 Sep 11.

University of Ottawa Heart Institute, Ottawa, Canada (R.J., E.L.T., N.L., S.M., G.R., J.S., B.Y., M.B., V.C., M.R., T.D.R., E.J.S., D.R.D.).

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http://dx.doi.org/10.1161/JAHA.115.002104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4599498PMC
September 2015

Discordant Regulation of microRNA Between Multiple Experimental Models and Human Pulmonary Hypertension.

Chest 2015 Aug;148(2):481-490

From the Regenerative Medicine Program, Ottawa Hospital Research Institute), Ottawa, ON, Canada; Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON, Canada. Electronic address:

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http://dx.doi.org/10.1378/chest.14-2169DOI Listing
August 2015

Circulating angiogenic cell dysfunction in patients with hereditary hemorrhagic telangiectasia.

PLoS One 2014 25;9(2):e89927. Epub 2014 Feb 25.

Division of Cardiology, Keenan Research Center for Biomedical Science at the Li Ka Shing Knowledge Institute, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0089927PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3934937PMC
January 2015

The current state of stem cell therapeutics: Canadian approaches in the international context.

Can J Cardiol 2014 Nov 4;30(11):1361-9. Epub 2014 May 4.

Department of Surgery, Peter Munk Cardiac Centre, University Health Network, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.cjca.2014.04.031DOI Listing
November 2014

Regenerative cell and tissue-based therapies for pulmonary arterial hypertension.

Can J Cardiol 2014 Nov 27;30(11):1350-60. Epub 2014 Aug 27.

Ottawa Hospital Research Institute, Sinclair Centre for Regenerative Medicine and Regenerative Medicine Program, and University of Ottawa, Faculty of Medicine, Department of Cellular and Molecular Medicine, Ottawa, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.cjca.2014.08.022DOI Listing
November 2014

Proteomic analysis implicates translationally controlled tumor protein as a novel mediator of occlusive vascular remodeling in pulmonary arterial hypertension.

Circulation 2014 May 21;129(21):2125-35. Epub 2014 Mar 21.

From the Ottawa Hospital Research Institute, Sprott Centre for Stem Cell Research and Regenerative Medicine Program, Ottawa, ON, Canada (J.R.L., C.P.-I., D.W.C., B.J., W.S.F., D.J.S.); University of Ottawa, Faculty of Medicine, Department of Cellular and Molecular Medicine, Ottawa, ON, Canada (J.R.L., W.S.F., D.J.S.); University of Cambridge, Department of Medicine, Addenbrooke's Hospital, Cambridge, UK (M.L.O., E.F., P.C., N.W.M.); and Papworth Hospital, Department of Pathology, Papworth, UK (M.S.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.114.008777DOI Listing
May 2014

Adult stem cells: potential implications for perioperative medicine.

Can J Anaesth 2014 Apr 8;61(4):299-305. Epub 2014 Feb 8.

Department of Anesthesiology, The Ottawa Hospital Research Institute, University of Ottawa, Civic Campus, Room B307, 1053 Carling Avenue, Mail Stop 249, Ottawa, ON, K1Y 4E9, Canada,

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http://dx.doi.org/10.1007/s12630-014-0121-1DOI Listing
April 2014

eNOS overexpressing bone marrow cells are safe and effective in a porcine model of myocardial regeneration following acute myocardial infarction.

Cardiovasc Ther 2013 Dec;31(6):e72-8

Keenan Research Centre of the LI-Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, ON, Canada.

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http://dx.doi.org/10.1111/1755-5922.12037DOI Listing
December 2013

miR-26a linked to pulmonary hypertension by global assessment of circulating extracellular microRNAs.

Am J Respir Crit Care Med 2013 Dec;188(12):1472-5

1 Ottawa Hospital Research Institute Ottawa, Ontario, Canada and University of Ottawa Ottawa, Ontario, Canada.

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http://www.atsjournals.org/doi/abs/10.1164/rccm.201308-1403L
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http://dx.doi.org/10.1164/rccm.201308-1403LEDOI Listing
December 2013

Effects of mesenchymal stem cell therapy on the time course of pulmonary remodeling depend on the etiology of lung injury in mice.

Crit Care Med 2013 Nov;41(11):e319-33

1Laboratory of Pulmonary Investigation, Carlos Chagas Filho Institute of Biophysics, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil. 2Laboratory of Cellular and Molecular Physiology, Carlos Chagas Filho Institute of Biophysics, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil. 3The Keenan Research Centre of the Li Ka Shing Knowledge Institute of St. Michael's Hospital, Toronto, ON, Canada. 4Interdepartmental Division of Critical Care, University of Toronto, Toronto, ON, Canada. 5Laboratory of Cellular and Molecular Cardiology, Carlos Chagas Filho Institute of Biophysics, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil. 6Laboratory of Inflammation, Carlos Chagas Filho Institute of Biophysics, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil. 7The Ottawa Hospital Research Institute, University of Ottawa, Ottawa, ON, Canada.

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http://dx.doi.org/10.1097/CCM.0b013e31828a663eDOI Listing
November 2013

Targeted delivery of genes to endothelial cells and cell- and gene-based therapy in pulmonary vascular diseases.

Compr Physiol 2013 Oct;3(4):1749-79

Sprott Centre for Stem Cell Research, The Ottawa Hospital Research Institute and University of Ottawa, Ottawa, Ontario, Canada.

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http://doi.wiley.com/10.1002/cphy.c120034
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http://dx.doi.org/10.1002/cphy.c120034DOI Listing
October 2013

Human blood and cardiac stem cells synergize to enhance cardiac repair when cotransplanted into ischemic myocardium.

Circulation 2013 Sep;128(11 Suppl 1):S105-12

University of Ottawa Heart Institute, Department of Cardiology, Ottawa, Ontario, Canada (N.L., B.Y., R.J., B.-K.L., D.K., M.R., E.J.S., D.R.D.); and Ottawa Hospital Research Institute, Department of Medicine, Ottawa, Ontario, Canada (D.J.S.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.112.000374DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3846533PMC
September 2013

Endothelin-2 deficiency causes growth retardation, hypothermia, and emphysema in mice.

J Clin Invest 2013 Jun 8;123(6):2643-53. Epub 2013 May 8.

Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390-8584, USA.

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http://www.jci.org/articles/view/66735
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http://dx.doi.org/10.1172/JCI66735DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3668837PMC
June 2013

A lymphocyte-dependent mode of action for imatinib mesylate in experimental pulmonary hypertension.

Am J Pathol 2013 May 19;182(5):1541-51. Epub 2013 Mar 19.

Terrence Donnelly Cardiovascular Research Laboratories, St. Michael's Hospital, Toronto, Ontario, Canada.

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https://linkinghub.elsevier.com/retrieve/pii/S00029440130011
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http://dx.doi.org/10.1016/j.ajpath.2013.01.031DOI Listing
May 2013

Tie2-dependent neovascularization of the ischemic hindlimb is mediated by angiopoietin-2.

PLoS One 2012 25;7(9):e43568. Epub 2012 Sep 25.

Terrence Donnelly Research Laboratories, Division of Cardiology, St. Michael's Hospital, Canada.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0043568PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3458045PMC
April 2013

Feeder-independent derivation of induced-pluripotent stem cells from peripheral blood endothelial progenitor cells.

Stem Cell Res 2013 Mar 3;10(2):195-202. Epub 2012 Dec 3.

Sprott Centre for Stem Cell Research, Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, Canada.

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http://dx.doi.org/10.1016/j.scr.2012.11.006DOI Listing
March 2013

A direct comparison of endothelial progenitor cell dysfunction in rat metabolic syndrome and diabetes.

Atherosclerosis 2013 Jan 10;226(1):58-66. Epub 2012 Oct 10.

Division of Cardiology, Keenan Research Centre in the Li Ka Shing Knowledge Institute, St. Michael's Hospital, University of Toronto, 6-044 Queen Wing, 30 Bond Street, Toronto, Ontario, Canada M5B 1W8.

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https://linkinghub.elsevier.com/retrieve/pii/S00219150120064
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http://dx.doi.org/10.1016/j.atherosclerosis.2012.09.029DOI Listing
January 2013

Network analysis of transcriptional responses induced by mesenchymal stem cell treatment of experimental sepsis.

Am J Pathol 2012 Nov;181(5):1681-92

Interdepartmental Division of Critical Care, The Keenan Research Centre of the Li Ka Shing Knowledge Institute of St. Michael's Hospital, University of Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.ajpath.2012.08.009DOI Listing
November 2012

Exosomes: cell garbage can, therapeutic carrier, or trojan horse?

Circulation 2012 Nov 31;126(22):2553-5. Epub 2012 Oct 31.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.112.146738DOI Listing
November 2012

Selectins for cardiosphere culture: the "E's" have it!

Mol Ther 2012 Jul;20(7):1296-7

Division of Cardiology, University of Ottawa Heart Institute, Ottawa, Ontario, Canada.

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http://dx.doi.org/10.1038/mt.2012.120DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3392986PMC
July 2012

Petersen hernia complicating laparoscopic duodenal switch.

Surg Obes Relat Dis 2012 Mar-Apr;8(2):236-8. Epub 2011 Dec 7.

Department of Bariatric Surgery, Gravitas, Bourne End, United Kingdom.

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http://dx.doi.org/10.1016/j.soard.2011.11.012DOI Listing
May 2012

Genetically modified endothelial progenitor cells in the therapy of cardiovascular disease and pulmonary hypertension.

Curr Vasc Pharmacol 2012 May;10(3):289-99

Ottawa Hospital Research Institute, Critical Care Wing, Ottawa, Ontario, Canada.

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http://dx.doi.org/10.2174/157016112799959413DOI Listing
May 2012

Sustained improvement in perfusion and flow reserve after temporally separated delivery of vascular endothelial growth factor and angiopoietin-1 plasmid deoxyribonucleic acid.

J Am Coll Cardiol 2012 Apr;59(14):1320-8

Division of Cardiology, Keenan Research Centre--Li Ka Shing Knowledge Institute, St. Michael's Hospital, University of Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.jacc.2011.12.025DOI Listing
April 2012

Cell-based therapies for lung vascular diseases: lessons for the future.

Proc Am Thorac Soc 2011 Nov;8(6):535-40

Ottawa Hospital Research Institute, The Ottawa Hospital, 501 Smyth Road, Ottawa, ON, K1H 8L6 Canada.

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http://dx.doi.org/10.1513/pats.201105-035MWDOI Listing
November 2011

Differential roles of endothelin-1 in angiotensin II-induced atherosclerosis and aortic aneurysms in apolipoprotein E-null mice.

Am J Pathol 2011 Sep 29;179(3):1549-59. Epub 2011 Jun 29.

Terrence Donnelly Research Laboratories, Division of Cardiology, St. Michael's Hospital, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.ajpath.2011.05.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3157254PMC
September 2011

VEGF masks BNIP3-mediated apoptosis of hypoxic endothelial cells.

Angiogenesis 2011 May 13;14(2):199-207. Epub 2011 Feb 13.

St. Michael's Hospital, Toronto, ON, Canada.

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http://dx.doi.org/10.1007/s10456-011-9204-6DOI Listing
May 2011

Vascular gene transfer of SDF-1 promotes endothelial progenitor cell engraftment and enhances angiogenesis in ischemic muscle.

Mol Ther 2011 May 1;19(5):895-902. Epub 2011 Mar 1.

Division of Cardiology, Keenan Research Centre in Li Ka Shing Knowledge Institute, St Michael's Hospital, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1038/mt.2011.18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3098636PMC
May 2011

Autologous cell therapy for cardiac repair.

Expert Opin Biol Ther 2011 Apr 8;11(4):489-508. Epub 2011 Feb 8.

University of Ottawa Heart Institute, Ottawa, Ontario, K1Y 4W7, Canada.

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http://www.tandfonline.com/doi/full/10.1517/14712598.2011.55
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http://dx.doi.org/10.1517/14712598.2011.556615DOI Listing
April 2011

Electrical remodelling precedes heart failure in an endothelin-1-induced model of cardiomyopathy.

Cardiovasc Res 2011 Feb 9;89(3):623-33. Epub 2010 Nov 9.

Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1093/cvr/cvq351DOI Listing
February 2011

The role of transglutaminase 2 and osteopontin in matrix protein supplemented microencapsulation of marrow stromal cells.

Biomaterials 2010 Dec;31(35):9256-65

The Ottawa Hospital Research Institute, 501 Smyth Road, Ottawa, Ontario, Canada.

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http://dx.doi.org/10.1016/j.biomaterials.2010.08.060DOI Listing
December 2010