Dudley K Strickland

Dudley K Strickland

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Dudley K Strickland

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High-affinity binding of plasminogen-activator inhibitor 1 complexes to LDL receptor-related protein 1 requires lysines 80, 88, and 207.

J Biol Chem 2020 Jan 2;295(1):212-222. Epub 2019 Dec 2.

Center for Vascular and Inflammatory Diseases and the Departments of Surgery and Physiology, University of Maryland School of Medicine, Baltimore, Maryland 21201

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http://dx.doi.org/10.1074/jbc.RA119.010449DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6952620PMC
January 2020

Paul E. Bock, PhD (21 October, 1949-11 October, 2019).

J Thromb Haemost 2020 Jan;18(1):262-263

University of Maryland, Baltimore, MD, USA.

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http://dx.doi.org/10.1111/jth.14680DOI Listing
January 2020

Fibrin-VLDL Receptor-Dependent Pathway Promotes Leukocyte Transmigration by Inhibiting Src Kinase Fyn and is a Target for Fibrin β15-42 Peptide.

Thromb Haemost 2019 Nov 29;119(11):1816-1826. Epub 2019 Aug 29.

Center for Vascular and Inflammatory Diseases, University of Maryland School of Medicine, Baltimore, Maryland, United States.

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http://dx.doi.org/10.1055/s-0039-1695008DOI Listing
November 2019

Role of the LDL Receptor-Related Protein 1 in Regulating Protease Activity and Signaling Pathways in the Vasculature.

Curr Drug Targets 2018 ;19(11):1276-1288

Center for Vascular and Inflammatory Diseases, Biopark I, R213, 800 W. Baltimore Street, Baltimore, Maryland 21201, MD, United States.

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http://dx.doi.org/10.2174/1389450119666180511162048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6812522PMC
October 2019

Macrophage LRP1 Promotes Diet-Induced Hepatic Inflammation and Metabolic Dysfunction by Modulating Wnt Signaling.

Mediators Inflamm 2018 4;2018:7902841. Epub 2018 Nov 4.

Center for Vascular and Inflammatory Diseases, University of Maryland School of Medicine, Baltimore, MD 21201, USA.

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http://dx.doi.org/10.1155/2018/7902841DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6247401PMC
February 2019

Pathogen Identification Direct From Polymicrobial Specimens Using Membrane Glycolipids.

Sci Rep 2018 10 26;8(1):15857. Epub 2018 Oct 26.

Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, MD, 21201, USA.

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http://www.nature.com/articles/s41598-018-33681-8
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http://dx.doi.org/10.1038/s41598-018-33681-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6203844PMC
October 2018

Quantitative Micro-CT Analysis of Aortopathy in a Mouse Model of β-aminopropionitrile-induced Aortic Aneurysm and Dissection.

J Vis Exp 2018 07 16(137). Epub 2018 Jul 16.

Center for Vascular and Inflammatory Diseases, University of Maryland School of Medicine; Division of Vascular Surgery, University of Maryland School of Medicine.

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https://www.jove.com/video/57589/quantitative-micro-ct-analy
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http://dx.doi.org/10.3791/57589DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6126473PMC
July 2018

The LDL Receptor-Related Protein 1: At the Crossroads of Lipoprotein Metabolism and Insulin Signaling.

J Diabetes Res 2017 11;2017:8356537. Epub 2017 May 11.

Center for Vascular and Inflammatory Diseases, University of Maryland School of Medicine, Baltimore, MD, USA.

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http://dx.doi.org/10.1155/2017/8356537DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5444004PMC
April 2018

Decreased non-specific adhesivity, receptor targeted (DART) nanoparticles exhibit improved dispersion, cellular uptake, and tumor retention in invasive gliomas.

J Control Release 2017 Dec 5;267:144-153. Epub 2017 Sep 5.

Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA; Marlene and Stewart Greenebaum Comprehensive Cancer Center, University of Maryland School of Medicine, Baltimore, MD 21201, USA; Department of Pharmacology, University of Maryland School of Medicine, Baltimore, MD 21201, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jconrel.2017.09.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5723214PMC
December 2017

Microglial-mediated PDGF-CC activation increases cerebrovascular permeability during ischemic stroke.

Acta Neuropathol 2017 Oct 19;134(4):585-604. Epub 2017 Jul 19.

Department of Physiology, Center for Vascular and Inflammatory Diseases, University of Maryland School of Medicine, BioPark-1, Room 211, 800 W. Baltimore Street, Baltimore, MD, 21201, USA.

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http://dx.doi.org/10.1007/s00401-017-1749-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5587628PMC
October 2017

Identification of the ESKAPE pathogens by mass spectrometric analysis of microbial membrane glycolipids.

Sci Rep 2017 07 25;7(1):6403. Epub 2017 Jul 25.

Department of Pharmaceutical Sciences, University of Maryland, Baltimore, MD, 21201, USA.

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http://dx.doi.org/10.1038/s41598-017-04793-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5526941PMC
July 2017

Murine Aortic Crush Injury: An Efficient In Vivo Model of Smooth Muscle Cell Proliferation and Endothelial Function.

J Vis Exp 2017 06 11(124). Epub 2017 Jun 11.

Department of Surgery, Baltimore Veterans Affairs Medical Center; Department of Surgery, University of Maryland School of Medicine; Center for Vascular and Inflammatory Diseases, University of Maryland School of Medicine;

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http://dx.doi.org/10.3791/55201DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5608387PMC
June 2017

MMP-13 is constitutively produced in human chondrocytes and co-endocytosed with ADAMTS-5 and TIMP-3 by the endocytic receptor LRP1.

Matrix Biol 2016 12 12;56:57-73. Epub 2016 Apr 12.

Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology, and Musculoskeletal Sciences, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1016/j.matbio.2016.03.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5146981PMC
December 2016

Evidence That Factor VIII Forms a Bivalent Complex with the Low Density Lipoprotein (LDL) Receptor-related Protein 1 (LRP1): IDENTIFICATION OF CLUSTER IV ON LRP1 AS THE MAJOR BINDING SITE.

J Biol Chem 2016 Dec 29;291(50):26035-26044. Epub 2016 Oct 29.

From the Center for Vascular and Inflammatory Disease and the Departments of Surgery and Physiology, University of Maryland School of Medicine, Baltimore, Maryland 21201

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http://dx.doi.org/10.1074/jbc.M116.754622DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5207074PMC
December 2016

Anti-VLDL receptor monoclonal antibodies inhibit fibrin-VLDL receptor interaction and reduce fibrin-dependent leukocyte transmigration.

Thromb Haemost 2016 Nov 1;116(6):1122-1130. Epub 2016 Sep 1.

Dr. Leonid Medved, PhD, University of Maryland School of Medicine, Center for Vascular and Inflammatory Diseases, 800 West Baltimore Street, Baltimore, MD, 21201, USA, Tel.: +1 410 706 8065, Fax: +1 410 706 8121, E-mail:

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http://dx.doi.org/10.1160/TH16-04-0333DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5294920PMC
November 2016

Engineered Tissue Inhibitor of Metalloproteinases-3 Variants Resistant to Endocytosis Have Prolonged Chondroprotective Activity.

J Biol Chem 2016 Oct 31;291(42):22160-22172. Epub 2016 Aug 31.

From the Arthritis Research UK Centre for Osteoarthritis Pathogenesis, Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology, and Musculoskeletal Sciences, University of Oxford, Roosevelt Drive, Oxford OX3 7FY, United Kingdom,

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http://dx.doi.org/10.1074/jbc.M116.733261DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5063997PMC
October 2016

High Affinity Binding of the Receptor-associated Protein D1D2 Domains with the Low Density Lipoprotein Receptor-related Protein (LRP1) Involves Bivalent Complex Formation: CRITICAL ROLES OF LYSINES 60 AND 191.

J Biol Chem 2016 08 11;291(35):18430-9. Epub 2016 Jul 11.

From the Center for Vascular and Inflammatory Disease and the Departments of Surgery and Physiology, University of Maryland School of Medicine, Baltimore, Maryland 21201

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http://dx.doi.org/10.1074/jbc.M116.744904DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5000088PMC
August 2016

MARCKS Signaling Differentially Regulates Vascular Smooth Muscle and Endothelial Cell Proliferation through a KIS-, p27kip1- Dependent Mechanism.

PLoS One 2015 3;10(11):e0141397. Epub 2015 Nov 3.

Department of Surgery, Baltimore Veterans Affairs Medical Center, Baltimore, Maryland, United States of America; Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland, United States of America; Center for Vascular and Inflammatory Diseases, University of Maryland School of Medicine, Baltimore, Maryland, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0141397PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4631550PMC
June 2016

LDL Receptor-Related Protein-1 (LRP1) Regulates Cholesterol Accumulation in Macrophages.

PLoS One 2015 10;10(6):e0128903. Epub 2015 Jun 10.

Center for Vascular and Inflammatory Diseases, University of Maryland School of Medicine, Baltimore, MD 21201, United States of America; Department of Physiology, University of Maryland School of Medicine, Baltimore, MD 21201, United States of America; Department of Surgery, University of Maryland School of Medicine, Baltimore, MD 21201, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0128903PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4463855PMC
March 2016

Regulation of Itch and Nedd4 E3 Ligase Activity and Degradation by LRAD3.

Biochemistry 2016 Mar 17;55(8):1204-13. Epub 2016 Feb 17.

Center for Vascular and Inflammatory Diseases and the ‡Departments of Surgery and §Physiology, University of Maryland School of Medicine , Baltimore, Maryland 21201, United States.

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http://dx.doi.org/10.1021/acs.biochem.5b01218DOI Listing
March 2016

LRP in Endothelial Cells: A Little Goes a Long Way.

Arterioscler Thromb Vasc Biol 2016 Feb;36(2):213-6

From the Center for Vascular and Inflammatory Disease (D.K.S., S.C.M.), Departments of Surgery (D.K.S.), and Physiology (D.K.S., S.C.M.), University of Maryland School of Medicine, Baltimore.

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http://dx.doi.org/10.1161/ATVBAHA.115.306895DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4732572PMC
February 2016

Myristoylated Alanine-Rich Protein Kinase Substrate (MARCKS) Regulates Small GTPase Rac1 and Cdc42 Activity and Is a Critical Mediator of Vascular Smooth Muscle Cell Migration in Intimal Hyperplasia Formation.

J Am Heart Assoc 2015 Oct 8;4(10):e002255. Epub 2015 Oct 8.

Department of Surgery, Veterans Affairs Medical Center, Baltimore, MD (D.Y., T.S.M.) Department of Surgery, University of Maryland School of Medicine, Baltimore, MD (D.Y., G.M., D.K.S., R.S., T.S.M.) Center for Vascular and Inflammatory Disease, University of Maryland School of Medicine, Baltimore, MD (D.Y., D.K.S., R.S., T.S.M.).

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http://dx.doi.org/10.1161/JAHA.115.002255DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4845127PMC
October 2015

Generation of a Potent Low Density Lipoprotein Receptor-related Protein 1 (LRP1) Antagonist by Engineering a Stable Form of the Receptor-associated Protein (RAP) D3 Domain.

J Biol Chem 2015 Jul 26;290(28):17262-8. Epub 2015 May 26.

From the Center for Vascular and Inflammatory Disease and the Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland 21201.

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http://dx.doi.org/10.1074/jbc.M115.660084DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4498065PMC
July 2015

Smooth muscle cell deletion of low-density lipoprotein receptor-related protein 1 augments angiotensin II-induced superior mesenteric arterial and ascending aortic aneurysms.

Arterioscler Thromb Vasc Biol 2015 Jan 13;35(1):155-62. Epub 2014 Nov 13.

From the Saha Cardiovascular Research Center (F.M.D., D.L.R., A.B., D.A.H., C.M.H., B.K.F., A.D.), Department of Pediatrics (B.K.F.), Department of Pharmacology and Nutritional Sciences (L.A.C.), University of Kentucky, Lexington; and Center for Vascular and Inflammatory Diseases, University of Maryland School of Medicine, Baltimore (D.K.S., S.C.M.).

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http://dx.doi.org/10.1161/ATVBAHA.114.304683DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4332619PMC
January 2015

Low-density lipoprotein receptor-related protein-1: role in the regulation of vascular integrity.

Arterioscler Thromb Vasc Biol 2014 Mar 6;34(3):487-98. Epub 2014 Feb 6.

From the Center for Vascular and Inflammatory Disease (D.K.S., D.T.A., P.C., S.C.M.), Departments of Surgery (D.K.S.), and Physiology (S.C.M.), University of Maryland School of Medicine, Baltimore.

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http://dx.doi.org/10.1161/ATVBAHA.113.301924DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4304649PMC
March 2014

LRP1 protects the vasculature by regulating levels of connective tissue growth factor and HtrA1.

Arterioscler Thromb Vasc Biol 2013 Sep 18;33(9):2137-46. Epub 2013 Jul 18.

Center for Vascular and Inflammatory Disease, Departments of Physiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.

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http://dx.doi.org/10.1161/ATVBAHA.113.301893DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3892666PMC
September 2013

LRP-1-mediated endocytosis regulates extracellular activity of ADAMTS-5 in articular cartilage.

FASEB J 2013 Feb 11;27(2):511-21. Epub 2012 Oct 11.

Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology, and Musculoskeletal Sciences, University of Oxford, London, UK.

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http://dx.doi.org/10.1096/fj.12-216671DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3545526PMC
February 2013

Macrophage LRP1 suppresses neo-intima formation during vascular remodeling by modulating the TGF-β signaling pathway.

PLoS One 2011 9;6(12):e28846. Epub 2011 Dec 9.

Center for Vascular and Inflammatory Diseases, School of Medicine, University of Maryland, Baltimore, Maryland, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0028846PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3235159PMC
April 2012

Identification of VLDLR as a novel endothelial cell receptor for fibrin that modulates fibrin-dependent transendothelial migration of leukocytes.

Blood 2012 Jan 17;119(2):637-44. Epub 2011 Nov 17.

Center for Vascular and Inflammatory Diseases, University of Maryland School of Medicine, Baltimore, 21201, USA.

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http://dx.doi.org/10.1182/blood-2011-09-382580DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3257021PMC
January 2012

Serpin-Enzyme Receptors LDL Receptor-Related Protein 1.

Methods Enzymol 2011 ;499:17-31

Center for Vascular and Inflammatory Diseases, University of Maryland School of Medicine, Baltimore, Maryland, USA.

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https://linkinghub.elsevier.com/retrieve/pii/B97801238647100
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http://dx.doi.org/10.1016/B978-0-12-386471-0.00002-XDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3189627PMC
October 2011

Murine missing in metastasis (MIM) mediates cell polarity and regulates the motility response to growth factors.

PLoS One 2011 9;6(6):e20845. Epub 2011 Jun 9.

The Center for Vascular and Inflammatory Diseases, University of Maryland School of Medicine, Baltimore, Maryland, United of States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0020845PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3111439PMC
October 2011

LRAD3, a novel low-density lipoprotein receptor family member that modulates amyloid precursor protein trafficking.

J Neurosci 2011 Jul;31(30):10836-46

Center for Vascular and Inflammatory Diseases and the Departments of Surgery and Physiology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA.

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http://dx.doi.org/10.1523/JNEUROSCI.5065-10.2011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3189500PMC
July 2011

Low density lipoprotein receptor-related protein-1 (LRP1) regulates thrombospondin-2 (TSP2) enhancement of Notch3 signaling.

J Biol Chem 2010 Jul 14;285(30):23047-55. Epub 2010 May 14.

Department of Neurology, University of Michigan, Ann Arbor, Michigan 48109-5622, USA.

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http://dx.doi.org/10.1074/jbc.M110.144634DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2906298PMC
July 2010

Inhibition of Abeta aggregation and neurotoxicity by the 39-kDa receptor-associated protein.

J Neurochem 2010 Mar 10;112(5):1199-209. Epub 2009 Dec 10.

Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Monash University, Victoria, Australia.

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http://doi.wiley.com/10.1111/j.1471-4159.2009.06540.x
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http://dx.doi.org/10.1111/j.1471-4159.2009.06540.xDOI Listing
March 2010

A new plasminogen receptor.

Blood 2010 Feb;115(7):1315-6

University of Maryland School of Medicine, USA.

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http://dx.doi.org/10.1182/blood-2009-11-254045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2826755PMC
February 2010

Microglial low-density lipoprotein receptor-related protein 1 mediates the effect of tissue-type plasminogen activator on matrix metalloproteinase-9 activity in the ischemic brain.

J Cereb Blood Flow Metab 2009 Dec 12;29(12):1946-54. Epub 2009 Aug 12.

Department of Neurology and Center for Neurodegenerative Disease, Emory University School of Medicine, Atlanta, Georgia 30322, USA.

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http://journals.sagepub.com/doi/10.1038/jcbfm.2009.174
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http://dx.doi.org/10.1038/jcbfm.2009.174DOI Listing
December 2009

Microglial low-density lipoprotein receptor-related protein 1 modulates c-Jun N-terminal kinase activation.

J Neuroimmunol 2009 Sep 7;214(1-2):25-32. Epub 2009 Jul 7.

Department of Neuroscience, Georgetown University, Washington, DC 20057-1464, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S016557280900227
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http://dx.doi.org/10.1016/j.jneuroim.2009.06.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2745483PMC
September 2009

Peptide-mediated targeting of hepatocytes via low density lipoprotein receptor-related protein (LRP).

Drug Deliv 2009 Jul;16(5):268-73

Waisman Center, Departments of Pediatrics and Medical Genetics, University of Wisconsin-Madison, Madison, WI 53705, USA.

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http://dx.doi.org/10.1080/10717540902975000DOI Listing
July 2009

Regulation of platelet-derived growth factor receptor function by integrin-associated cell surface transglutaminase.

J Biol Chem 2009 Jun 22;284(24):16693-703. Epub 2009 Apr 22.

Department of Biochemistry and Molecular Biology, Center for Vascular and Inflammatory Diseases, University of Maryland School of Medicine, Baltimore, MD 21201, USA.

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http://dx.doi.org/10.1074/jbc.M109.010769DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2713562PMC
June 2009

The low-density lipoprotein receptor-related protein 1 mediates tissue-type plasminogen activator-induced microglial activation in the ischemic brain.

Am J Pathol 2009 Feb 15;174(2):586-94. Epub 2009 Jan 15.

Department of Neurology and Center for Neurodegenerative Disease, Emory University School of Medicine, Atlanta, GA 30322, USA.

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http://dx.doi.org/10.2353/ajpath.2009.080661DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2630566PMC
February 2009

Proteases and lipoprotein receptors in Alzheimer's disease.

Cell Biochem Biophys 2004 ;41(1):139-78

Department of Surgery and Physiology, University of MarylandSchool of Medicine, Baltimore, MD, USA.

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http://dx.doi.org/10.1385/CBB:41:1:139DOI Listing
January 2009

The LDL receptor-related protein can form homo-dimers in neuronal cells.

Neurosci Lett 2008 Sep 28;442(2):91-5. Epub 2008 Jun 28.

MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1016/j.neulet.2008.06.070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2565777PMC
September 2008

Activation of PDGF-CC by tissue plasminogen activator impairs blood-brain barrier integrity during ischemic stroke.

Nat Med 2008 Jul 22;14(7):731-7. Epub 2008 Jun 22.

Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan Medical School, Ann Arbor Michigan 48109-0644, USA.

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http://dx.doi.org/10.1038/nm1787DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2811427PMC
July 2008

LDL receptor-related protein 1: unique tissue-specific functions revealed by selective gene knockout studies.

Physiol Rev 2008 Jul;88(3):887-918

Center for Vascular and Inflammatory Diseases and Department of Surgery and Physiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.

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http://www.physiology.org/doi/10.1152/physrev.00033.2007
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http://dx.doi.org/10.1152/physrev.00033.2007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2744109PMC
July 2008

The binding sites for the very low density lipoprotein receptor and low-density lipoprotein receptor-related protein are shared within coagulation factor VIII.

Blood Coagul Fibrinolysis 2008 Mar;19(2):166-77

Center for Vascular and Inflammatory Diseases, Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, Maryland, USA.

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https://insights.ovid.com/crossref?an=00001721-200803000-000
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http://dx.doi.org/10.1097/MBC.0b013e3282f5457bDOI Listing
March 2008

Thrombospondins use the VLDL receptor and a nonapoptotic pathway to inhibit cell division in microvascular endothelial cells.

Mol Biol Cell 2008 Feb 21;19(2):563-71. Epub 2007 Nov 21.

Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.

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http://dx.doi.org/10.1091/mbc.e07-07-0649DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2230579PMC
February 2008

Localization of the low-density lipoprotein receptor-related protein regions involved in binding to the A2 domain of coagulation factor VIII.

Thromb Haemost 2007 Dec;98(6):1170-81

Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, Maryland, USA.

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December 2007

Cell-surface transglutaminase undergoes internalization and lysosomal degradation: an essential role for LRP1.

J Cell Sci 2007 Sep 21;120(Pt 18):3188-99. Epub 2007 Aug 21.

Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.

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http://dx.doi.org/10.1242/jcs.010397DOI Listing
September 2007

NMR assignment of domain 2 of the receptor-associated protein.

J Biomol NMR 2006 ;36 Suppl 1:54

Protein-Nucleic Acid Interactions Section, Structural Biophysics Laboratory, Center for Cancer Research, National Cancer Institute-Frederick, National Institutes of Health, Frederick, MD 21702, USA.

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http://link.springer.com/10.1007/s10858-006-9034-9
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http://dx.doi.org/10.1007/s10858-006-9034-9DOI Listing
August 2007

NMR assignment of domain 3 of the receptor-associated protein (RAP).

J Biomol NMR 2006 3;36 Suppl 1:56. Epub 2006 Oct 3.

Protein-Nucleic Acid Interactions Section, Structural Biophysics Laboratory, Center for Cancer Research, NCI Frederick, NIH, Frederick, Maryland 21702, USA.

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http://link.springer.com/10.1007/s10858-006-9036-7
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http://dx.doi.org/10.1007/s10858-006-9036-7DOI Listing
August 2007

The structure of receptor-associated protein (RAP).

Protein Sci 2007 Aug;16(8):1628-40

Protein-Nucleic Acid Interaction Section, Structural Biophysics Laboratory, National Cancer Institute at Frederick, National Institutes of Health, Frederick, Maryland 21702, USA.

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http://dx.doi.org/10.1110/ps.072865407DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2203372PMC
August 2007

gamma-Secretase-mediated release of the low density lipoprotein receptor-related protein 1B intracellular domain suppresses anchorage-independent growth of neuroglioma cells.

J Biol Chem 2007 Mar 16;282(10):7504-11. Epub 2007 Jan 16.

Center for Vascular and Inflammatory Disease and the Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA.

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March 2007

Fluorescence lifetime imaging microscopy (FLIM) detects stimulus-dependent phosphorylation of the low density lipoprotein receptor-related protein (LRP) in primary neurons.

Biochem Biophys Res Commun 2006 Oct 14;349(1):24-30. Epub 2006 Aug 14.

Alzheimer's Disease Research Unit, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1016/j.bbrc.2006.07.212DOI Listing
October 2006

Dissection of RAP-LRP interactions: binding of RAP and RAP fragments to complement-like repeats 7 and 8 from ligand binding cluster II of LRP.

Arch Biochem Biophys 2006 Jun 5;450(2):167-75. Epub 2006 May 5.

Department of Biochemistry and Molecular Genetics, College of Medicine, University of Illinois at Chicago, Chicago, IL 60607, USA.

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http://dx.doi.org/10.1016/j.abb.2006.04.007DOI Listing
June 2006

Endocytic receptor LRP together with tPA and PAI-1 coordinates Mac-1-dependent macrophage migration.

EMBO J 2006 May 6;25(9):1860-70. Epub 2006 Apr 6.

Department of Physiology and Surgery, Center for Vascular and Inflammatory Diseases, University of Maryland School of Medicine, Baltimore, 21201, USA.

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http://dx.doi.org/10.1038/sj.emboj.7601082DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1456942PMC
May 2006

RAP uses a histidine switch to regulate its interaction with LRP in the ER and Golgi.

Mol Cell 2006 May;22(3):423-30

Protein-Nucleic Acid Interaction Section, Structural Biophysics Laboratory, National Cancer Institute at Frederick, National Institutes of Health, Frederick, Maryland 21702, USA.

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http://dx.doi.org/10.1016/j.molcel.2006.04.011DOI Listing
May 2006

Identification of coagulation factor VIII A2 domain residues forming the binding epitope for low-density lipoprotein receptor-related protein.

Biochemistry 2006 Feb;45(6):1829-40

Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA.

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February 2006

A specific role of integrin Mac-1 in accelerated macrophage efflux to the lymphatics.

Blood 2005 Nov 7;106(9):3234-41. Epub 2005 Jul 7.

Department of Physiology, University of Maryland School of Medicine, 15601 Crabbs Branch Way, Rockville, MD 20855, USA.

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http://dx.doi.org/10.1182/blood-2005-03-1288DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1895336PMC
November 2005

Low density lipoprotein receptor-related protein (LRP) interacts with presenilin 1 and is a competitive substrate of the amyloid precursor protein (APP) for gamma-secretase.

J Biol Chem 2005 Jul 25;280(29):27303-9. Epub 2005 May 25.

Alzheimer Research Unit, Massachusetts Institute for Neurodegenerative Disorders, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA.

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July 2005

Platelet-derived growth factor receptor-beta (PDGFR-beta) activation promotes its association with the low density lipoprotein receptor-related protein (LRP). Evidence for co-receptor function.

J Biol Chem 2005 Jul 8;280(30):27872-8. Epub 2005 Jun 8.

Department of Surgery and Physiology, University of Maryland School of Medicine, 15601 Crabbs Branch Way, Rockville, Maryland 20855, USA.

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http://dx.doi.org/10.1074/jbc.M505410200DOI Listing
July 2005

NMR structural studies of domain 1 of receptor-associated protein.

J Biomol NMR 2004 Jul;29(3):271-9

Protein-Nucleic Acid Interaction Section, Structural Biophysics Laboratory, National Cancer Institute at Frederick, National Institutes of Health, Frederick, MD 21702, USA.

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http://dx.doi.org/10.1023/B:JNMR.0000032507.96325.6dDOI Listing
July 2004

The low density lipoprotein receptor-related protein LRP is regulated by membrane type-1 matrix metalloproteinase (MT1-MMP) proteolysis in malignant cells.

J Biol Chem 2004 Feb 25;279(6):4260-8. Epub 2003 Nov 25.

Cancer Research Center, the Burnham Institute, La Jolla, California 92037, USA.

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February 2004

Structural organization of the receptor associated protein.

Biochemistry 2003 Dec;42(50):14913-20

Department of Biochemistry and Molecular Genetics, College of Medicine, University of Illinois at Chicago, Chicago, Illinois 60607-7170, USA.

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http://dx.doi.org/10.1021/bi035779eDOI Listing
December 2003

The cytoplasmic domain of the low density lipoprotein (LDL) receptor-related protein, but not that of the LDL receptor, triggers phagocytosis.

J Biol Chem 2003 Nov 26;278(45):44799-807. Epub 2003 Aug 26.

Department of Medicine, Columbia University, New York, New York 10032, USA.

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November 2003

Tissue-type plasminogen activator induces opening of the blood-brain barrier via the LDL receptor-related protein.

J Clin Invest 2003 Nov;112(10):1533-40

Department of Vascular Biology, Holland Laboratory, American Red Cross, Rockville, Maryland 20855, USA.

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http://dx.doi.org/10.1172/JCI19212DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC259131PMC
November 2003

Modulation of the LDL receptor and LRP levels by HIV protease inhibitors.

J Lipid Res 2003 Oct 1;44(10):1859-69. Epub 2003 Jul 1.

Department of Vascular Biology, Jerome H. Holland Laboratories, American Red Cross, Rockville, MD 20855, USA.

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http://dx.doi.org/10.1194/jlr.M200487-JLR200DOI Listing
October 2003

The intracellular domain of the low density lipoprotein receptor-related protein modulates transactivation mediated by amyloid precursor protein and Fe65.

J Biol Chem 2003 Oct 29;278(42):41182-8. Epub 2003 Jul 29.

Alzheimer Disease Research Laboratory, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA.

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http://dx.doi.org/10.1074/jbc.M306403200DOI Listing
October 2003

Low density lipoprotein receptor-related protein is a calreticulin coreceptor that signals focal adhesion disassembly.

J Cell Biol 2003 Jun;161(6):1179-89

Department of Pathology, Division of Molecular and Cellular Pathology and The Cell Adhesion and Matrix Research Center, University of Alabama at Birmingham, VH 668 1530, 3rd Ave. South, Birmingham, AL 35294-0019, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172996PMC
June 2003

Allosteric modulation of ligand binding to low density lipoprotein receptor-related protein by the receptor-associated protein requires critical lysine residues within its carboxyl-terminal domain.

J Biol Chem 2003 May 12;278(20):17986-92. Epub 2003 Mar 12.

Department of Vascular Biology, Jerome H. Holland Laboratory for the Biomedical Sciences, American Red Cross, Rockville, Maryland 20855, USA.

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http://dx.doi.org/10.1074/jbc.M212592200DOI Listing
May 2003

The three-dimensional structure of the human alpha 2-macroglobulin dimer reveals its structural organization in the tetrameric native and chymotrypsin alpha 2-macroglobulin complexes.

J Biol Chem 2002 Aug 15;277(31):28031-7. Epub 2002 May 15.

Department of Pathology and Laboratory Medicine, University of Texas-Houston Medical School, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1074/jbc.M202714200DOI Listing
August 2002

LRP and senile plaques in Alzheimer's disease: colocalization with apolipoprotein E and with activated astrocytes.

Brain Res Mol Brain Res 2002 Jul;104(1):38-46

Alzheimer Research Unit, Department of Neurology, Massachusetts General Hospital, 114 16th Street, Room 2009, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1016/s0169-328x(02)00203-6DOI Listing
July 2002

The low density lipoprotein receptor-related protein mediates fibronectin catabolism and inhibits fibronectin accumulation on cell surfaces.

J Biol Chem 2002 May 26;277(18):16160-6. Epub 2002 Feb 26.

Department of Pathology, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA.

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http://dx.doi.org/10.1074/jbc.M201401200DOI Listing
May 2002

alpha 2-Macroglobulin exposure reduces calcium responses to N-methyl-D-aspartate via low density lipoprotein receptor-related protein in cultured hippocampal neurons.

J Biol Chem 2002 Apr 11;277(17):14458-66. Epub 2002 Feb 11.

Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA.

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http://dx.doi.org/10.1074/jbc.M112066200DOI Listing
April 2002

Diverse roles for the LDL receptor family.

Trends Endocrinol Metab 2002 Mar;13(2):66-74

Department Vascular Biology, Holland Laboratory, American Red Cross, Rockville, MD 20855, USA.

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http://dx.doi.org/10.1016/s1043-2760(01)00526-4DOI Listing
March 2002