Duanqing Pei

Duanqing Pei

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Duanqing Pei

Publications by authors named "Duanqing Pei"

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Establishment of peripheral blood mononuclear cell-derived humanized lung cancer mouse models for studying efficacy of PD-L1/PD-1 targeted immunotherapy.

MAbs 2018 Nov-Dec;10(8):1301-1311. Epub 2018 Oct 2.

b Key Laboratory of Regenerative Biology, South China Institute for Stem Cell Biology and Regenerative Medicine , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , Guangzhou , China.

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http://dx.doi.org/10.1080/19420862.2018.1518948DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284590PMC
June 2019

Induction of Pluripotent Stem Cells from Mouse Embryonic Fibroblasts by Jdp2-Jhdm1b-Mkk6-Glis1-Nanog-Essrb-Sall4.

Cell Rep 2019 Jun;27(12):3473-3485.e5

CAS Key Laboratory of Regenerative Biology, South China Institutes for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China; Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, South China Stem Cell and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China; Guangzhou Regenerative Medicine and Health Guangdong Laboratory at GIBH, Guangzhou 510530, China. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.05.068DOI Listing
June 2019

Resolving Cell Fate Decisions during Somatic Cell Reprogramming by Single-Cell RNA-Seq.

Mol Cell 2019 02 13;73(4):815-829.e7. Epub 2019 Feb 13.

CAS Key Laboratory of Regenerative Biology, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China; Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangzhou 510530, China; Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou Medical University, Guangzhou 511436, China; University of Chinese Academy of Sciences, Beijing 100049, China; Guangzhou Regenerative Medicine and Health GuangDong Laboratory (GRMH-GDL), Guangzhou 510005, China. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2019.01.042DOI Listing
February 2019

Hemi-methylated CpG sites connect -knockdown-induced and -induced DNA demethylation during somatic cell reprogramming.

Cell Discov 2019 12;5:11. Epub 2019 Feb 12.

1CAS Key Laboratory of Regenerative Biology, Hefei Institute of Stem Cell and Regenerative Medicine, Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou Medical University, 510530 Guangzhou, China.

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http://www.nature.com/articles/s41421-018-0074-6
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http://dx.doi.org/10.1038/s41421-018-0074-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370818PMC
February 2019

Mesothelin is a target of chimeric antigen receptor T cells for treating gastric cancer.

J Hematol Oncol 2019 Feb 18;12(1):18. Epub 2019 Feb 18.

Key Laboratory of Regenerative Biology, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China.

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https://jhoonline.biomedcentral.com/articles/10.1186/s13045-
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http://dx.doi.org/10.1186/s13045-019-0704-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380000PMC
February 2019

Rejuvenation of β cells by epigenetic editing.

J Clin Invest 2019 Jan 26;129(1):51-52. Epub 2018 Nov 26.

Guangzhou Institutes of Biomedicine and Health.

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http://dx.doi.org/10.1172/JCI124583DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307952PMC
January 2019

Mesenchymal-epithelial transition in development and reprogramming.

Nat Cell Biol 2019 01 2;21(1):44-53. Epub 2019 Jan 2.

CAS Key Laboratory of Regenerative Biology, Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China.

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http://dx.doi.org/10.1038/s41556-018-0195-zDOI Listing
January 2019

Short-Term Mitochondrial Permeability Transition Pore Opening Modulates Histone Lysine Methylation at the Early Phase of Somatic Cell Reprogramming.

Cell Metab 2018 12 30;28(6):935-945.e5. Epub 2018 Aug 30.

CAS Key Laboratory of Regenerative Biology, Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences; Guangzhou Medical University, Guangzhou 510530, China; Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, CUHK-GIBH Joint Research Laboratory on Stem Cells and Regenerative Medicine, South China Institute for Stem Cell Biology and Regenerative Medicine, Institute for Stem Cell and Regeneration, Guangzhou Institutes of Biomedicine and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Guangzhou 510530, China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15504131183050
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http://dx.doi.org/10.1016/j.cmet.2018.08.001DOI Listing
December 2018

The Battle between TET Proteins and DNA Methylation for the Right Cell.

Trends Cell Biol 2018 12 3;28(12):973-975. Epub 2018 Nov 3.

CAS Key Laboratory of Regenerative Biology, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China; Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China; Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou Medical University, Guangzhou 511436, China; Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China; University of Chinese Academy of Sciences, Beijing 100049, China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09628924183017
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http://dx.doi.org/10.1016/j.tcb.2018.10.002DOI Listing
December 2018

BMI1 enables interspecies chimerism with human pluripotent stem cells.

Nat Commun 2018 11 7;9(1):4649. Epub 2018 Nov 7.

Key Laboratory of Regenerative Biology of Chinese Academy of Sciences, Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou Medical University, 510530, Guangzhou, China.

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http://dx.doi.org/10.1038/s41467-018-07098-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6220315PMC
November 2018

DNAX-activating protein 10 co-stimulation enhances the anti-tumor efficacy of chimeric antigen receptor T cells.

Oncoimmunology 2019 2;8(1):e1509173. Epub 2018 Nov 2.

Key Laboratory of Regenerative Biology, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China.

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https://www.tandfonline.com/doi/full/10.1080/2162402X.2018.1
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http://dx.doi.org/10.1080/2162402X.2018.1509173DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287795PMC
November 2018

The homeobox transcription factor MSX2 partially mediates the effects of bone morphogenetic protein 4 (BMP4) on somatic cell reprogramming.

J Biol Chem 2018 09 10;293(38):14905-14915. Epub 2018 Aug 10.

From the Chinese Academy of Sciences Key Laboratory of Regenerative Biology, Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China, Guangzhou Medical University, Guangzhou 511436, China,

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http://dx.doi.org/10.1074/jbc.RA118.003913DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6153288PMC
September 2018

Mouse embryonic stem cells resist c-Jun induced differentiation when in suspension.

Cell Regen (Lond) 2018 Sep 17;7(1):16-21. Epub 2018 Jul 17.

CAS Key Laboratory of Regenerative Biology, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China.

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https://linkinghub.elsevier.com/retrieve/pii/S20459769183000
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http://dx.doi.org/10.1016/j.cr.2018.05.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326245PMC
September 2018

Deficiency in class III PI3-kinase confers postnatal lethality with IBD-like features in zebrafish.

Nat Commun 2018 07 6;9(1):2639. Epub 2018 Jul 6.

CAS Key Laboratory of Regenerative Biology, Guangzhou Institute of Biomedicine and Health-Guangzhou Medical University Joint School of Biological Sciences, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, 510530, Guangzhou, China.

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http://dx.doi.org/10.1038/s41467-018-05105-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6035235PMC
July 2018

Lower genomic stability of induced pluripotent stem cells reflects increased non-homologous end joining.

Cancer Commun (Lond) 2018 07 25;38(1):49. Epub 2018 Jul 25.

Key Laboratory of Genomic and Precision Medicine, China Gastrointestinal Cancer Research Center, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, 100101, P. R. China.

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http://dx.doi.org/10.1186/s40880-018-0313-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6060453PMC
July 2018

Chromatin Accessibility Dynamics during Chemical Induction of Pluripotency.

Cell Stem Cell 2018 04;22(4):529-542.e5

CAS Key Laboratory of Regenerative Biology, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China; Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China; Guangzhou Branch of the Supercomputing Center of Chinese Academy of Sciences, Guangzhou 510530, China; CUHK-GIBH Joint Laboratory of Stem Cell and Regenerative Medicine, Chinese University of Hong Kong, Shatin, Hong Kong SAR, China; GUANGZHOU Regenerative Medicine and Health Guangdong Laboratory at GIBH, Guangzhou 510530, China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S19345909183011
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http://dx.doi.org/10.1016/j.stem.2018.03.005DOI Listing
April 2018

Chromatin Accessibility Dynamics during iPSC Reprogramming.

Cell Stem Cell 2017 Dec;21(6):819-833.e6

CAS Key Laboratory of Regenerative Biology, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China; Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China; Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou Medical University, Guangzhou 511436, China; University of Chinese Academy of Sciences, Beijing 100049, China; GUANGZHOU Regenerative Medicine and Health Laboratory, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2017.10.012DOI Listing
December 2017

CD215+ Myeloid Cells Respond to Interleukin 15 Stimulation and Promote Tumor Progression.

Front Immunol 2017 4;8:1713. Epub 2017 Dec 4.

Key Laboratory of Regenerative Biology, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China.

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http://dx.doi.org/10.3389/fimmu.2017.01713DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5722806PMC
December 2017

Defined, serum/feeder-free conditions for expansion and drug screening of primary B-acute lymphoblastic leukemia.

Oncotarget 2017 Dec 15;8(63):106382-106392. Epub 2017 Nov 15.

Key Laboratory of Regenerative Biology, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China.

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http://dx.doi.org/10.18632/oncotarget.22466DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5739741PMC
December 2017

Passive DNA demethylation preferentially up-regulates pluripotency-related genes and facilitates the generation of induced pluripotent stem cells.

J Biol Chem 2017 11 18;292(45):18542-18555. Epub 2017 Sep 18.

From the CAS Key Laboratory of Regenerative Biology, Joint School of Life Sciences between Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, Guangdong 510530, China and Guangzhou Medical University, Guangzhou, Guangdong 511436,

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http://dx.doi.org/10.1074/jbc.M117.810457DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5682964PMC
November 2017

Chemical reprogramming of mouse embryonic and adult fibroblast into endoderm lineage.

J Biol Chem 2017 11 21;292(46):19122-19132. Epub 2017 Sep 21.

From the Key Laboratory of Regenerative Biology, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Beijing 100049, China,

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http://dx.doi.org/10.1074/jbc.M117.812537DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5704493PMC
November 2017

Kdm2b Regulates Somatic Reprogramming through Variant PRC1 Complex-Dependent Function.

Cell Rep 2017 Nov;21(8):2160-2170

CAS Key Laboratory of Regenerative Biology, Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China; Guangzhou Medical University, Guangzhou, China; Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China; Guangzhou Branch of the Supercomputing Center of Chinese Academy of Sciences, Guangzhou 510530, China. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.10.091DOI Listing
November 2017

Human Embryo Editing: Opportunities and Importance of Transnational Cooperation.

Cell Stem Cell 2017 10;21(4):423-426

California Institute of Technology, Pasadena, CA 91125, USA; Organizing Committee for the International Summit on Human Gene Editing.

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http://dx.doi.org/10.1016/j.stem.2017.09.010DOI Listing
October 2017

Gadd45a opens up the promoter regions of miR-295 facilitating pluripotency induction.

Cell Death Dis 2017 10 12;8(10):e3107. Epub 2017 Oct 12.

CAS Key Laboratory of Regenerative Biology, Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, Guangzhou Medical University, Guangzhou, China.

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http://dx.doi.org/10.1038/cddis.2017.497DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5682663PMC
October 2017

PRC2 specifies ectoderm lineages and maintains pluripotency in primed but not naïve ESCs.

Nat Commun 2017 09 22;8(1):672. Epub 2017 Sep 22.

CAS Key Laboratory of Regenerative Biology, Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou Medical University, Guangzhou, 511436, China.

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http://dx.doi.org/10.1038/s41467-017-00668-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5610324PMC
September 2017

SNX16 Regulates the Recycling of E-Cadherin through a Unique Mechanism of Coordinated Membrane and Cargo Binding.

Structure 2017 08 14;25(8):1251-1263.e5. Epub 2017 Jul 14.

State Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China; Guangdong Provincial Key Laboratory of Biocomputing, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China. Electronic address:

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http://dx.doi.org/10.1016/j.str.2017.06.015DOI Listing
August 2017

Generation of tooth-periodontium complex structures using high-odontogenic potential dental epithelium derived from mouse embryonic stem cells.

Stem Cell Res Ther 2017 06 8;8(1):141. Epub 2017 Jun 8.

Department of Oral and Maxillofacial Surgery/Central Laboratory, Peking University School and Hospital of Stomatology, National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing Key Laboratory of Digital Stomatology, Beijing, 100081, People's Republic of China.

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http://dx.doi.org/10.1186/s13287-017-0583-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5465544PMC
June 2017

A sequential EMT-MET mechanism drives the differentiation of human embryonic stem cells towards hepatocytes.

Nat Commun 2017 05 3;8:15166. Epub 2017 May 3.

CAS Key laboratory of Regenerative Biology, Guangdong Key laboratory of Stem Cell and Regenerative Medicine and CUHK-GIBH Joint Research Laboratory on Stem Cells and Regenerative Medicine, Guangzhou Institute of Biomedicine and Health-Guangzhou Medical University Joint School of Biological Sciences, South China Institute of Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, 190 Kai Yuan Avenue, Science Park, Guangzhou 510530, China.

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http://dx.doi.org/10.1038/ncomms15166DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5418622PMC
May 2017

Sequential EMT-MET induces neuronal conversion through Sox2.

Cell Discov 2017 30;3:17017. Epub 2017 May 30.

CAS Key Laboratory of Regenerative Biology, Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou Medical University, Guangzhou, China.

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http://dx.doi.org/10.1038/celldisc.2017.17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5450022PMC
May 2017

RNA Helicase DDX5 Inhibits Reprogramming to Pluripotency by miRNA-Based Repression of RYBP and its PRC1-Dependent and -Independent Functions.

Cell Stem Cell 2017 04 19;20(4):462-477.e6. Epub 2017 Jan 19.

CAS Key Laboratory of Regenerative Biology, Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, CAS Center for Excellence in Molecular Cell Science, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2016.12.002DOI Listing
April 2017

Deubiquitylating Nanog: novel role of USP21 in embryonic stem cell maintenance.

Authors:
Duanqing Pei

Signal Transduct Target Ther 2017 21;2:17014. Epub 2017 Apr 21.

Key Laboratory of Regenerative Biology, Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences 510530, Guangzhou.

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http://dx.doi.org/10.1038/sigtrans.2017.14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5661622PMC
April 2017

Incorporation of a hinge domain improves the expansion of chimeric antigen receptor T cells.

J Hematol Oncol 2017 03 13;10(1):68. Epub 2017 Mar 13.

Key Laboratory of Regenerative Biology, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510530, China.

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http://dx.doi.org/10.1186/s13045-017-0437-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5347831PMC
March 2017

Models of global gene expression define major domains of cell type and tissue identity.

Nucleic Acids Res 2017 03;45(5):2354-2367

Key Laboratory of Regenerative Biology of the Chinese Academy of Sciences and Guangdong Provincial Key Laboratory of Stem Cells and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, Guangdong 510530, China.

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http://dx.doi.org/10.1093/nar/gkx054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5389706PMC
March 2017

PSCA and MUC1 in non-small-cell lung cancer as targets of chimeric antigen receptor T cells.

Oncoimmunology 2017 6;6(3):e1284722. Epub 2017 Feb 6.

Key Laboratory of Regenerative Biology, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China; Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China; State Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China.

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http://dx.doi.org/10.1080/2162402X.2017.1284722DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5384358PMC
February 2017

Anti-GPC3-CAR T Cells Suppress the Growth of Tumor Cells in Patient-Derived Xenografts of Hepatocellular Carcinoma.

Front Immunol 2016 11;7:690. Epub 2017 Jan 11.

State Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China; Key Laboratory of Regenerative Biology, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China; Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China.

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http://dx.doi.org/10.3389/fimmu.2016.00690DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5225101PMC
January 2017

Epigenetic Landmarks During Somatic Reprogramming.

IUBMB Life 2016 11;68(11):854-857

Key Laboratory of Regenerative Biology, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510530, China.

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http://dx.doi.org/10.1002/iub.1577DOI Listing
November 2016

Gadd45a is a heterochromatin relaxer that enhances iPS cell generation.

EMBO Rep 2016 11 4;17(11):1641-1656. Epub 2016 Oct 4.

Key Laboratory of Regenerative Biology, Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China

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http://dx.doi.org/10.15252/embr.201642402DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5090707PMC
November 2016

Heterogeneity of CD34 and CD38 expression in acute B lymphoblastic leukemia cells is reversible and not hierarchically organized.

J Hematol Oncol 2016 Sep 22;9(1):94. Epub 2016 Sep 22.

State Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, 190 Kaiyuan Avenue, Science Park, Guangzhou, Guangdong, 510530, China.

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http://dx.doi.org/10.1186/s13045-016-0310-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5034590PMC
September 2016

Remission for Loss of Odontogenic Potential in a New Micromilieu In Vitro.

PLoS One 2016 6;11(4):e0152893. Epub 2016 Apr 6.

Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology, Beijing 100081, P.R. China.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0152893PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4822848PMC
August 2016

Lysine-specific histone demethylase 1 inhibition promotes reprogramming by facilitating the expression of exogenous transcriptional factors and metabolic switch.

Sci Rep 2016 08 2;6:30903. Epub 2016 Aug 2.

CAS Key Laboratory of Regenerative Biology, Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China.

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http://dx.doi.org/10.1038/srep30903DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4969595PMC
August 2016

Bioethics in China: No wild east.

Nature 2016 06;534(7608):465-7

Key Laboratory of Regenerative Biology, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health (GIBH), Chinese Academy of Sciences, Guangzhou, China, and is director-general of the GIBH.

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http://dx.doi.org/10.1038/534465aDOI Listing
June 2016

Sorting Nexin 11 Regulates Lysosomal Degradation of Plasma Membrane TRPV3.

Traffic 2016 May 23;17(5):500-14. Epub 2016 Feb 23.

Key Laboratory of Regenerative Biology, Chinese Academy of Sciences and Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China.

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http://dx.doi.org/10.1111/tra.12379DOI Listing
May 2016

Simple and versatile synthetic polydopamine-based surface supports reprogramming of human somatic cells and long-term self-renewal of human pluripotent stem cells under defined conditions.

Biomaterials 2016 May 10;87:1-17. Epub 2016 Feb 10.

Department of Oral and Maxillofacial Surgery, Laboratory of Interdisciplinary Studies, School and Hospital of Stomatology, Peking University, Beijing, 100081, China; Center for Biomedical Materials and Tissue Engineering, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, 100871, China. Electronic address:

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http://dx.doi.org/10.1016/j.biomaterials.2016.02.012DOI Listing
May 2016

TGFβ signaling regulates the choice between pluripotent and neural fates during reprogramming of human urine derived cells.

Sci Rep 2016 Mar 3;6:22484. Epub 2016 Mar 3.

Key Laboratory of Regenerative Biology, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China.

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http://dx.doi.org/10.1038/srep22484DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4776143PMC
March 2016

Pluripotency without Proliferation.

Cell 2016 Feb;164(4):595-7

Key Laboratory of Regenerative Biology of the Chinese Academy of Sciences and Guangdong Provincial Key Laboratory of Stem Cells and Regenerative Medicine, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China. Electronic address:

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February 2016

Insight into the maintenance of odontogenic potential in mouse dental mesenchymal cells based on transcriptomic analysis.

PeerJ 2016 22;4:e1684. Epub 2016 Feb 22.

Department of Oral and Maxillofacial Surgery, Laboratory of Interdisciplinary Studies, Peking University School and Hospital of Stomatology, Beijing, China.

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http://dx.doi.org/10.7717/peerj.1684DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4768683PMC
February 2016

Srebp-1 Interacts with c-Myc to Enhance Somatic Cell Reprogramming.

Stem Cells 2016 Jan 29;34(1):83-92. Epub 2015 Sep 29.

Key Laboratory of Regenerative Biology, Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, People's Republic of China.

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January 2016

Transient Activation of Mitoflashes Modulates Nanog at the Early Phase of Somatic Cell Reprogramming.

Cell Metab 2016 Jan 5;23(1):220-6. Epub 2015 Nov 5.

The Key Laboratory of Regenerative Biology, Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2015.10.002DOI Listing
January 2016

Induced Pluripotent Stem Cells to Model Human Fibrodysplasia Ossificans Progressiva.

Stem Cell Reports 2015 Dec 26;5(6):963-970. Epub 2015 Nov 26.

Department of Molecular Cell Biology, Cancer Genomics Centre Netherlands, Leiden University Medical Center, Leiden 2300, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2015.10.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4682290PMC
December 2015

Dynamically reorganized chromatin is the key for the reprogramming of somatic cells to pluripotent cells.

Sci Rep 2015 Dec 7;5:17691. Epub 2015 Dec 7.

Key Laboratory of Regenerative Biology, CAS Center for Excellence in Molecular Cell Science, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510530, China.

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http://dx.doi.org/10.1038/srep17691DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4671053PMC
December 2015

Reprogramming somatic cells to cells with neuronal characteristics by defined medium both in vitro and in vivo.

Cell Regen (Lond) 2015 30;4:12. Epub 2015 Dec 30.

CAS Key Laboratory of Regenerative Biology, Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, #190 Kaiyuan Avenue, Science City, Guangzhou, 510530 China.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4696146PMC
December 2015

Loss of ATOH8 Increases Stem Cell Features of Hepatocellular Carcinoma Cells.

Gastroenterology 2015 Oct 20;149(4):1068-81.e5. Epub 2015 Jun 20.

Department of Clinical Oncology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China; Centre for Cancer Research, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China; State Key Laboratory of Liver Research, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China; State Key Laboratory of Oncology in Southern China, Sun Yat-sen University Cancer Center, Guangzhou, China. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2015.06.010DOI Listing
October 2015

Stem cell aging in adult progeria.

Cell Regen (Lond) 2015 3;4. Epub 2015 Oct 3.

CUHK-CAS GIBH Joint Research Laboratory on Stem Cell and Regenerative Medicine, School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong S.A.R., China ; The Chinese University of Hong Kong, Room G03A, Lo Kwee-Seong Intergrated Biomedical Science Building, Shatin, N.T., Hong Kong S.A.R., China.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4592574PMC
October 2015

Transposable elements at the center of the crossroads between embryogenesis, embryonic stem cells, reprogramming, and long non-coding RNAs.

Sci Bull (Beijing) 2015;60(20):1722-1733. Epub 2015 Oct 13.

Key Laboratory of Regenerative Biology, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510530 China ; Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510530 China ; Guangzhou Branch of the Supercomputing Center of Chinese Academy of Sciences, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510530 China.

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http://dx.doi.org/10.1007/s11434-015-0905-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4624819PMC
October 2015

Cyclin-dependent kinase-mediated Sox2 phosphorylation enhances the ability of Sox2 to establish the pluripotent state.

J Biol Chem 2015 Sep 2;290(37):22782-94. Epub 2015 Jul 2.

Stowers Institute for Medical Research, Kansas City, Missouri 64110, Department of Anatomy and Cell Biology, University of Kansas School of Medicine, Kansas City, Kansas 66160

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http://dx.doi.org/10.1074/jbc.M115.658195DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4566249PMC
September 2015

Hallmarks of pluripotency.

Nature 2015 Sep;525(7570):469-78

Stem Cell Transplantation Program, Division of Pediatric Hematology Oncology, Children's Hospital Boston, and Dana-Farber Cancer Institute; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA.

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September 2015

Failure to replicate the STAP cell phenomenon.

Nature 2015 Sep;525(7570):E6-9

Stem Cell Transplantation Program, Division of Pediatric Hematology Oncology, Children's Hospital Boston, and Dana-Farber Cancer Institute, Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1038/nature15513DOI Listing
September 2015

GATA2(-/-) human ESCs undergo attenuated endothelial to hematopoietic transition and thereafter granulocyte commitment.

Cell Regen (Lond) 2015 5;4(1). Epub 2015 Aug 5.

CAS Key Laboratory of Regenerative Biology, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510530 China ; Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510530 China.

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http://dx.doi.org/10.1186/s13619-015-0018-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4526303PMC
August 2015

Mitochondrial fusion provides an 'initial metabolic complementation' controlled by mtDNA.

Cell Mol Life Sci 2015 Jul 24;72(13):2585-98. Epub 2015 Feb 24.

Key Laboratory of Regenerative Biology, Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510530, China.

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http://dx.doi.org/10.1007/s00018-015-1863-9DOI Listing
July 2015

The oncogene c-Jun impedes somatic cell reprogramming.

Nat Cell Biol 2015 Jul 22;17(7):856-67. Epub 2015 Jun 22.

1] Key Laboratory of Regenerative Biology, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China [2] Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China [3] Guangzhou Branch of the Supercomputing Center of Chinese Academy of Sciences, Guangzhou 510530, China.

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http://dx.doi.org/10.1038/ncb3193DOI Listing
July 2015

Autophagy and mTORC1 regulate the stochastic phase of somatic cell reprogramming.

Nat Cell Biol 2015 Jun 18;17(6):715-25. Epub 2015 May 18.

1] Key Laboratory of Regenerative Biology of the Chinese Academy of Sciences and Guangdong Provincial Key Laboratory of Stem Cells and Regenerative Medicine, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China [2] Hong Kong-Guangdong Joint Laboratory on Stem Cell and Regenerative Medicine, the University of Hong Kong and Guangzhou Institutes of Biomedicine and Health, China.

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http://dx.doi.org/10.1038/ncb3172DOI Listing
June 2015

Valproic acid-induced hepatotoxicity in Alpers syndrome is associated with mitochondrial permeability transition pore opening-dependent apoptotic sensitivity in an induced pluripotent stem cell model.

Hepatology 2015 May 10;61(5):1730-9. Epub 2015 Mar 10.

Key Laboratory of Regenerative Biology, Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China; University of Science and Technology of China, Hefei, Anhui, China.

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http://dx.doi.org/10.1002/hep.27712DOI Listing
May 2015

ANGPTL7 regulates the expansion and repopulation of human hematopoietic stem and progenitor cells.

Haematologica 2015 May 30;100(5):585-94. Epub 2015 Jan 30.

Key Laboratory of Regenerative Biology, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, China Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, China

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http://dx.doi.org/10.3324/haematol.2014.118612DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4420207PMC
May 2015

Factor-induced Reprogramming and Zinc Finger Nuclease-aided Gene Targeting Cause Different Genome Instability in β-Thalassemia Induced Pluripotent Stem Cells (iPSCs).

J Biol Chem 2015 May 20;290(19):12079-89. Epub 2015 Mar 20.

From the Key Laboratory of Regenerative Biology, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China,

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http://dx.doi.org/10.1074/jbc.M114.624999DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4424344PMC
May 2015

Quantitative evaluation of the immunodeficiency of a mouse strain by tumor engraftments.

J Hematol Oncol 2015 May 29;8:59. Epub 2015 May 29.

Key Laboratory of Regenerative Biology, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510530, China.

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http://dx.doi.org/10.1186/s13045-015-0156-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4478639PMC
May 2015

Transitions between epithelial and mesenchymal states during cell fate conversions.

Protein Cell 2014 9;5(8):580-91. Epub 2014 May 9.

CAS Key Laboratory of Regenerative Biology, Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510530, China.

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http://dx.doi.org/10.1007/s13238-014-0064-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4130923PMC
March 2015

In vitro culture and directed osteogenic differentiation of human pluripotent stem cells on peptides-decorated two-dimensional microenvironment.

ACS Appl Mater Interfaces 2015 Mar 18;7(8):4560-72. Epub 2015 Feb 18.

Department of Oral and Maxillofacial Surgery, Laboratory of Interdisciplinary Studies, School and Hospital of Stomatology, Peking University , Beijing 100081, People's Republic of China.

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http://dx.doi.org/10.1021/acsami.5b00188DOI Listing
March 2015

Loss of Angiopoietin-like 7 diminishes the regeneration capacity of hematopoietic stem and progenitor cells.

J Hematol Oncol 2015 Feb 6;8. Epub 2015 Feb 6.

Key Laboratory of Regenerative Biology, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, 190 Kaiyuan Avenue, Science Park, Guangzhou, 7, Guangdong, 510530, China.

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http://dx.doi.org/10.1186/s13045-014-0102-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4353465PMC
February 2015

The p53-induced lincRNA-p21 derails somatic cell reprogramming by sustaining H3K9me3 and CpG methylation at pluripotency gene promoters.

Cell Res 2015 Jan 16;25(1):80-92. Epub 2014 Dec 16.

1] Laboratory of Chromatin and Human Disease, Chinese Academy of Sciences, Guangzhou, Guangdong 510530, China [2] Key Laboratory of Regenerative Biology, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, Guangdong 510530, China [3] Hong Kong - Guangdong Joint Laboratory of Stem Cells and Regenerative Medicine, the University of Hong Kong and Guangzhou Institutes of Biomedicine and Health, Guangzhou, Guangdong 510530, China.

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http://dx.doi.org/10.1038/cr.2014.165DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4650593PMC
January 2015

Structure of human SNX10 reveals insights into its role in human autosomal recessive osteopetrosis.

Proteins 2014 Dec 1;82(12):3483-9. Epub 2014 Oct 1.

State Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510530, China; School of Life Sciences, University of Science and Technology of China, Hefei, 230026, China.

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http://dx.doi.org/10.1002/prot.24689DOI Listing
December 2014

A reciprocal antagonism between miR-376c and TGF-β signaling regulates neural differentiation of human pluripotent stem cells.

FASEB J 2014 Nov 11;28(11):4642-56. Epub 2014 Aug 11.

Key Laboratory of Regenerative Biology and Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China

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http://dx.doi.org/10.1096/fj.13-249342DOI Listing
November 2014

Transcriptional pause release is a rate-limiting step for somatic cell reprogramming.

Cell Stem Cell 2014 Nov 9;15(5):574-88. Epub 2014 Oct 9.

Laboratory of Chromatin and Human Disease, Chinese Academy of Sciences, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Guangzhou 510530, China; Key Laboratory of Regenerative Biology, Chinese Academy of Sciences, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Guangzhou 510530, China; Hong Kong-Guangdong Joint Laboratory on Stem Cell and Regenerative Medicine, the University of Hong Kong and Guangzhou Institutes of Biomedicine and Health, China. Electronic address:

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http://www.cell.com/cms/attachment/2022533874/2042574651/mmc
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http://dx.doi.org/10.1016/j.stem.2014.09.018DOI Listing
November 2014

Characterization of a novel cell penetrating peptide derived from human Oct4.

Cell Regen (Lond) 2014 31;3(1). Epub 2014 Jan 31.

Department of Biotechnology, University of Natural Resources and Life Sciences, Muthgasse 18, 1190 Vienna, Austria ; Evercyte GmbH, Muthgasse 18, 1190 Vienna, Austria ; Christian Doppler Laboratory on Biotechnology of Skin Aging, University of Natural Resources and Life Sciences, Muthgasse 18, 1190 Vienna, Austria.

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http://dx.doi.org/10.1186/2045-9769-3-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4230757PMC
November 2014

Application of iPS cells in dental bioengineering and beyond.

Stem Cell Rev Rep 2014 Oct;10(5):663-70

CAS Key Laboratory of Regenerative Biology and Guangdong Provincial Key Laboratory of Stem Cell Biology and Regenerative Medicine, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, 190 Kai Yuan Avenue, Science Park, Guangzhou, 510530, People's Republic of China.

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http://dx.doi.org/10.1007/s12015-014-9531-2DOI Listing
October 2014

Where cell fate conversions meet Chinese philosophy.

Cell Res 2014 Oct 15;24(10):1162-3. Epub 2014 Jul 15.

Institute of Biochemistry and Cell Biology, Shanghai Institutes of Biological Sciences, Shanghai 200031, China.

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http://dx.doi.org/10.1038/cr.2014.93DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4185354PMC
October 2014

The function and regulation of mesenchymal-to-epithelial transition in somatic cell reprogramming.

Curr Opin Genet Dev 2014 Oct 29;28:32-7. Epub 2014 Aug 29.

Key Laboratory of Regenerative Biology, Chinese Academy of Sciences, and Guangdong Provincial Key Laboratory of Stem Cells and Regenerative Medicine, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Guangzhou 510530, China. Electronic address:

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http://dx.doi.org/10.1016/j.gde.2014.08.005DOI Listing
October 2014

Zfyve9a regulates the proliferation of hepatic cells during zebrafish embryogenesis.

Int J Dev Biol 2013 ;57(9-10):773-8

Key Laboratory of Regenerative Biology, Chinese Academy of Sciences, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Guangzhou, China.

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http://dx.doi.org/10.1387/ijdb.130065xsDOI Listing
September 2014

Cancer: pathological nuclear reprogramming?

Nat Rev Cancer 2014 Aug 17;14(8):568-73. Epub 2014 Jul 17.

Ludwig Institute for Cancer Research, Nuffield Department of Clinical Medicine, Old Road Campus Research Building, Old Road Campus, University of Oxford, Headington, Oxford OX3 7DQ, UK.

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http://dx.doi.org/10.1038/nrc3781DOI Listing
August 2014

Modeling of hemophilia A using patient-specific induced pluripotent stem cells derived from urine cells.

Life Sci 2014 Jul 13;108(1):22-9. Epub 2014 May 13.

Key Laboratory of Regenerative Biology, Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, P. R. China. Electronic address:

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http://dx.doi.org/10.1016/j.lfs.2014.05.004DOI Listing
July 2014

Low immunogenicity of neural progenitor cells differentiated from induced pluripotent stem cells derived from less immunogenic somatic cells.

PLoS One 2013 26;8(7):e69617. Epub 2013 Jul 26.

Key Laboratory of Regenerative Biology, Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine,Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, Guangdong Province, PR China.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0069617PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3724937PMC
April 2014

Tet and TDG mediate DNA demethylation essential for mesenchymal-to-epithelial transition in somatic cell reprogramming.

Cell Stem Cell 2014 Apr 13;14(4):512-22. Epub 2014 Feb 13.

Shanghai Key Laboratory of Molecular Andrology, The State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2014.01.001DOI Listing
April 2014

Generating a non-integrating human induced pluripotent stem cell bank from urine-derived cells.

PLoS One 2013 5;8(8):e70573. Epub 2013 Aug 5.

CAS Key Laboratory of Regenerative Biology, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, Guangdong, China.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0070573PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3734275PMC
March 2014

Neural progenitor cells from human induced pluripotent stem cells generated less autogenous immune response.

Sci China Life Sci 2014 Feb 17;57(2):162-70. Epub 2014 Jan 17.

Key Laboratory of Regenerative Biology, Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510530, China.

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http://dx.doi.org/10.1007/s11427-013-4598-6DOI Listing
February 2014

Genome-wide CNV analysis in mouse induced pluripotent stem cells reveals dosage effect of pluripotent factors on genome integrity.

BMC Genomics 2014 Jan 28;15:79. Epub 2014 Jan 28.

State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai 200433, China.

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http://dx.doi.org/10.1186/1471-2164-15-79DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3912500PMC
January 2014

Vitamin C modulates TET1 function during somatic cell reprogramming.

Nat Genet 2013 Dec 27;45(12):1504-9. Epub 2013 Oct 27.

1] Key Laboratory of Regenerative Biology, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China. [2] Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China. [3].

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http://dx.doi.org/10.1038/ng.2807DOI Listing
December 2013

Ribosomal RNA gene transcription mediated by the master genome regulator protein CCCTC-binding factor (CTCF) is negatively regulated by the condensin complex.

J Biol Chem 2013 Sep 24;288(36):26067-77. Epub 2013 Jul 24.

Key Laboratory of Regenerative Biology of the Chinese Academy of Sciences, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China.

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http://dx.doi.org/10.1074/jbc.M113.486175DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3764810PMC
September 2013

Pyrimido[4,5-d]pyrimidin-4(1H)-one derivatives as selective inhibitors of EGFR threonine790 to methionine790 (T790M) mutants.

Angew Chem Int Ed Engl 2013 Aug 26;52(32):8387-90. Epub 2013 Jun 26.

Institute of Chemical Biology, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, 190 Kaiyuan Avenue, Guangzhou 510530, China.

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http://dx.doi.org/10.1002/anie.201302313DOI Listing
August 2013

Sequential introduction of reprogramming factors reveals a time-sensitive requirement for individual factors and a sequential EMT-MET mechanism for optimal reprogramming.

Nat Cell Biol 2013 Jul 26;15(7):829-38. Epub 2013 May 26.

CAS Key Laboratory of Regenerative Biology, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China.

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http://dx.doi.org/10.1038/ncb2765DOI Listing
July 2013