Publications by authors named "Dror Harats"

100Publications

Addition of fish oil to atherogenic high fat diet inhibited atherogenesis while olive oil did not, in LDL receptor KO mice.

Nutr Metab Cardiovasc Dis 2020 04 14;30(4):709-716. Epub 2019 Dec 14.

The Bert W. Strassburger Lipid Center, Sheba Medical Center, Tel-Hashomer, 5265601, Ramat Gan, Israel; Achva Academic College, Israel.

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April 2020

Specific overexpression of 15-lipoxygenase in endothelial cells promotes cancer cell death in an in vivo Lewis lung carcinoma mouse model.

Adv Med Sci 2020 Mar 7;65(1):111-119. Epub 2020 Jan 7.

The Bert Strassburger Lipid Center, Sheba Medical Center, Tel-Hashomer, Israel; Achva Academic College, Beer-Tuvia Regional Council, Arugot, Israel. Electronic address:

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March 2020

IFNγ potentiates TNFα/TNFR1 signaling to induce FAT10 expression in macrophages.

Mol Immunol 2020 01 20;117:101-109. Epub 2019 Nov 20.

The Bert W. Strassburger Lipid Center, Sheba Medical Center, Tel-Hashomer, Israel; Sackler Faculty of Medicine, Tel-Aviv University, Israel. Electronic address:

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January 2020

ApoE Genotype, Lipid Profile, Exercise, and the Associations With Cardiovascular Morbidity and 18-Year Mortality.

J Gerontol A Biol Sci Med Sci 2020 Sep;75(10):1887-1893

Unit for Cardiovascular Epidemiology, The Gertner Institute for Epidemiology and Health Policy Research, Sheba Medical Center, Ramat Gan, Israel.

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September 2020

Interleukin-1α and Interleukin-1β play a central role in the pathogenesis of fulminant hepatic failure in mice.

PLoS One 2017 27;12(9):e0184084. Epub 2017 Sep 27.

The Liver Research Laboratory Chaim Sheba Medical Center, Tel Hashomer, Ramat Gan, Israel.

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October 2017

Interleukin 1-alpha deficiency increases the expression of Follicle-stimulating hormone receptors in granulosa cells.

Mol Reprod Dev 2017 Jun 17;84(6):460-467. Epub 2017 Apr 17.

Department of Cell and Developmental Biology, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.

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June 2017

Molecular genetics of familial hypercholesterolemia in Israel-revisited.

Atherosclerosis 2017 02 18;257:55-63. Epub 2016 Dec 18.

Center for Research Prevention and Treatment of Atherosclerosis, Department of Medicine, Hadassah Hebrew University Medical Center, Jerusalem, Israel.

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February 2017

Cardiovascular health among two ethnic groups living in the same region: A population-based study.

Int J Cardiol 2017 Feb 9;228:23-30. Epub 2016 Nov 9.

Cardiovascular Epidemiology Unit, Gertner Institute for Epidemiology and Health Policy Research, Sheba Medical Center, Ramat-Gan, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

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February 2017

Differential Effects of apoE4 and Activation of ABCA1 on Brain and Plasma Lipoproteins.

PLoS One 2016 8;11(11):e0166195. Epub 2016 Nov 8.

The Department of Neurobiology, The George S. Wise Faculty of Life Sciences, The Sagol School of Neuroscience, Tel Aviv University, Tel Aviv 6997801, Israel.

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June 2017

9-cis β-Carotene Increased Cholesterol Efflux to HDL in Macrophages.

Nutrients 2016 Jul 19;8(7). Epub 2016 Jul 19.

The Bert W. Strassburger Lipid Center, Sheba Medical Center, Tel-Hashomer 5265601, Israel.

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July 2016

Factor XI Deficiency Protects Against Atherogenesis in Apolipoprotein E/Factor XI Double Knockout Mice.

Arterioscler Thromb Vasc Biol 2016 Mar 21;36(3):475-81. Epub 2016 Jan 21.

From the The Bert W. Strassburger Lipid Center (R.S.G., D.H., H.L., A.S.) and Department of Pathology (G.S., C.A.), and Thrombosis Unit (R.S.G., I.T., O.S.), Sheba Medical Center, Tel-Hashomer, Israel; Sackler Faculty of Medicine (R.S.G., D.H., G.S., H.L., C.A., I.T., O.S.), Tel-Aviv University, Tel-Aviv, Israel; and Department of Pathology, Microbiology, and Immunology, Vanderbilt University, Nashville, TN (D.G.).

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March 2016

Thoracic Duct Narrowing-Innovative Technique Restraining Weight Gain in Rats.

Obes Surg 2015 Dec;25(12):2443-50

The Bert W. Strassburger Lipid Center, The Chaim Sheba Medical Center, Tel Hashomer, Ramat Gan, 52621, Israel.

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December 2015

Interleukin-1α deficiency attenuates endoplasmic reticulum stress-induced liver damage and CHOP expression in mice.

J Hepatol 2015 Oct 27;63(4):926-33. Epub 2015 May 27.

The Bert W. Strassburger Lipid Center, Sheba Medical Center, Tel Hashomer, Israel; Sackler Faculty of Medicine, Tel-Aviv University, Israel. Electronic address:

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October 2015

Vitamin A-deficient diet accelerated atherogenesis in apolipoprotein E(-/-) mice and dietary β-carotene prevents this consequence.

Biomed Res Int 2015 23;2015:758723. Epub 2015 Feb 23.

The Bert W. Strassburger Lipid Center, Sheba Medical Center, 5265601 Tel-Hashomer, Israel.

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May 2016

Knockdown of interleukin-1α does not attenuate LPS-induced production of interleukin-1β in mouse macrophages.

Cytokine 2015 May 6;73(1):138-43. Epub 2015 Mar 6.

The Bert W. Strassburger Lipid Center, Sheba Medical Center, Tel Hashomer, Israel; Sackler Faculty of Medicine, Tel-Aviv University, Israel. Electronic address:

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May 2015

The inhibition of macrophage foam cell formation by 9-cis β-carotene is driven by BCMO1 activity.

PLoS One 2015 28;10(1):e0115272. Epub 2015 Jan 28.

The Bert W. Strassburger Lipid Center, Sheba Medical Center, Tel-Hashomer, 5265601, Ramat-Gan, Israel.

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October 2015

Therapies targeting innate immunity for fighting inflammation in atherosclerosis.

Curr Pharm Des 2015 ;21(9):1185-95

Head of Immunology, VBL Therapeutics, 6 Jonathan Netanyahu St, Or Yehuda 60376, Israel.

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September 2015

Interleukin-1 deficiency prolongs ovarian lifespan in mice.

Proc Natl Acad Sci U S A 2014 Aug 11;111(34):12492-7. Epub 2014 Aug 11.

The Bert W. Strassburger Lipid Center, Sheba Medical Center, Tel-Hashomer 52621, Israel;

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August 2014

Lack of interleukin-1α in Kupffer cells attenuates liver inflammation and expression of inflammatory cytokines in hypercholesterolaemic mice.

Dig Liver Dis 2014 May 26;46(5):433-9. Epub 2014 Feb 26.

The Bert W. Strassburger Lipid Center, Sheba Medical Center, Tel Hashomer, Israel; Sackler Faculty of Medicine, Tel-Aviv University, Israel. Electronic address:

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May 2014

Low molecular weight heparin-induced increase in chylomicron-remnants clearance, is associated with decreased plasma TNF-α level and increased hepatic lipase activity.

Thromb Res 2014 Apr 21;133(4):688-92. Epub 2014 Jan 21.

The Bert Strassburger Lipid Center, Sheba Medical Center, Tel Hashomer, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

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April 2014

Prevention of atherosclerosis progression by 9-cis-β-carotene rich alga Dunaliella in apoE-deficient mice.

Biomed Res Int 2013 23;2013:169517. Epub 2013 Sep 23.

The Bert W. Strassburger Lipid Center, Sheba Medical Center, Tel Hashomer, 5265601 Ramat-Gan, Israel ; Sackler Faculty of Medicine, Tel-Aviv University, Ramat-Aviv, 69978 Tel-Aviv, Israel.

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June 2014

Intolerance to statins: mechanisms and management.

Diabetes Care 2013 Aug;36 Suppl 2:S325-30

Bert W. Strassburger Lipid Center, Sheba Medical Center, Tel Hashomer, Israel.

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August 2013

Phase I dose-escalation study of VB-111, an antiangiogenic virotherapy, in patients with advanced solid tumors.

Clin Cancer Res 2013 Jul 15;19(14):3996-4007. Epub 2013 Apr 15.

Institute for Drug Development, Cancer Therapy and Research Center, University of Texas Health Science Center at San Antonio, Texas, USA.

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July 2013

[Prevention and treatment of atherosclerosis and cardiovascular diseases].

Harefuah 2012 May;151(5):281-8, 319, 318

Unit of Diabetes & Metabolic Diseases, Kaplan Medical Center, Rehovot.

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May 2012

Apolipoprotein A-V modulates multiple atherogenic mechanisms in a mouse model of disturbed clearance of triglyceride-rich lipoproteins.

Atherosclerosis 2012 Sep 29;224(1):75-83. Epub 2012 May 29.

The Bert W. Strassburger Lipid Center, Sheba Medical Center, Tel-Hashomer, Israel.

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September 2012

Low-dose calcitriol decreases aortic renin, blood pressure, and atherosclerosis in apoe-null mice.

J Atheroscler Thromb 2012 16;19(5):422-34. Epub 2012 Apr 16.

The Institute of Endocrinology, Metabolism and Hypertension, Tel Aviv Sourasky Medical Center, Israel.

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September 2012

Alteration of lipids and the transcription of lipid-related genes in myelodysplastic syndromes via a TP53-related pathway.

Exp Hematol 2012 Jul 27;40(7):540-547.e1. Epub 2012 Feb 27.

Laboratory for Translational Hemato-Oncology Research, The Hematology Institute, Meir Medical Center, Kfar-Saba, Israel.

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July 2012

Metabolically regulated endoplasmic reticulum-associated degradation of 3-hydroxy-3-methylglutaryl-CoA reductase: evidence for requirement of a geranylgeranylated protein.

J Biol Chem 2011 Sep 21;286(37):32150-61. Epub 2011 Jul 21.

Department of Human Genetics and Biochemistry, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, Israel.

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September 2011

Serum apolipoproteins C-I and C-III are reduced in stomach cancer patients: results from MALDI-based peptidome and immuno-based clinical assays.

PLoS One 2011 Jan 18;6(1):e14540. Epub 2011 Jan 18.

The Shraga Segal Department of Microbiology and Immunology and the National Institute for Biotechnology in the Negev, Ben Gurion University of the Negev, Beer Sheva, Israel.

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January 2011

Fatty acid bile acid conjugate inhibits hepatic stearoyl coenzyme A desaturase and is non-atherogenic.

Arch Med Res 2010 Aug;41(6):397-404

Minerva Center for Cholesterol Gallstones and Lipid Metabolism in the Liver, Tel-Aviv University, Tel-Aviv, Israel.

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August 2010

Modified phospholipids as anti-inflammatory compounds.

Curr Opin Lipidol 2010 Dec;21(6):525-9

VBL Therapeutics, Or Yehuda, Israel.

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December 2010

The metabolic effects of omega-3 plant sterol esters in mixed hyperlipidemic subjects.

Cardiovasc Drugs Ther 2010 Dec;24(5-6):429-37

The Bert W. Strassburger Lipid Center, Sheba Medical Center, Tel Hashomer, Israel.

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December 2010

Conservative treatment of L-asparaginase-associated lipid abnormalities in children with acute lymphoblastic leukemia.

Pediatr Blood Cancer 2010 May;54(5):703-6

The Bert W. Strassburger Lipid Center, Sheba Medical Center, Tel-Hashomer, Israel.

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May 2010

Treatment of a retinal dystrophy, fundus albipunctatus, with oral 9-cis-{beta}-carotene.

Br J Ophthalmol 2010 May 2;94(5):616-21. Epub 2009 Dec 2.

Maurice and Gabriela Goldschleger Eye Research Institute, Sheba Medical Center, Tel-Hashomer 52621, Israel.

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May 2010

Should all diabetic patients be treated with a statin?

Diabetes Care 2009 Nov;32 Suppl 2:S378-83

Bert W. Strassburger Lipid Center, Chaim Sheba Medical Center, Tel Hashomer, Israel.

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November 2009

Triglycerides and HDL cholesterol: stars or second leads in diabetes?

Diabetes Care 2009 Nov;32 Suppl 2:S373-7

Bert W. Strassburger Lipid Center, Chaim Sheba Medical Center, Tel Hashomer, Israel.

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November 2009

Dislocation of HMG-CoA reductase and Insig-1, two polytopic endoplasmic reticulum proteins, en route to proteasomal degradation.

Mol Biol Cell 2009 Jul 20;20(14):3330-41. Epub 2009 May 20.

Department of Human Genetics and Biochemistry, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, Israel.

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July 2009

B-type natriuretic peptide enhances vasculogenesis by promoting number and functional properties of early endothelial progenitor cells.

Tissue Eng Part A 2009 Sep;15(9):2741-9

Department of Cardiology, Tel Aviv Sourasky Medical Center, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.

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September 2009

Endothelial-targeted Gene Transfer of Hypoxia-inducible Factor-1α Augments Ischemic Neovascularization Following Systemic Administration.

Mol Ther 2008 Dec 8;16(12):1927-1936. Epub 2016 Dec 8.

Vascular Biogenics Ltd., Or-Yehuda, Israel; The Bert W. Strassburger Lipid Center, Sheba Medical Center, Tel Hashomer, Israel. Electronic address:

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December 2008

A carotenoid algal preparation containing phytoene and phytofluene inhibited LDL oxidation in vitro.

Plant Foods Hum Nutr 2008 Jun 29;63(2):83-6. Epub 2008 Apr 29.

The Bert W. Strassburger Lipid Center, Sheba Medical Center, Tel-Hashomer, Israel.

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June 2008

Familial Mediterranean fever gene and protection against asthma.

Ann Allergy Asthma Immunol 2007 Dec;99(6):517-21

Heller Institute of Medical Research, Sheba Medical Center, Tel-Hashomer, Israel.

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December 2007

Rifampicin-induced CYP3A4 activation in CTX patients cannot replace chenodeoxycholic acid treatment.

Biochim Biophys Acta 2007 Jul 1;1771(7):839-44. Epub 2007 May 1.

Department of Internal Medicine B and the Center for Research Prevention and Treatment of Atherosclerosis, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.

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July 2007

[Cholesterol absorption as a target for the treatment of hypercholesterolemia].

Harefuah 2006 Nov;145(11):831-5, 861, 860

The Institute of Lipid and Atherosclerosis Research Sheba Medical Center, Tel Hashomer, Israel.

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November 2006

Differential role and tissue specificity of interleukin-1alpha gene expression in atherogenesis and lipid metabolism.

Atherosclerosis 2007 Nov 14;195(1):31-8. Epub 2006 Dec 14.

Institute of Lipid and Atherosclerosis Research, Sheba Medical Center, Tel Hashomer and Sackler Faculty of Medicine, Tel Aviv University, Tel Hashomer 52621, Israel.

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November 2007

Endothelin B receptor antagonist increases preproendothelin-1 transcription in bovine aortic endothelial cells and in vivo.

J Cardiovasc Pharmacol 2006 May;47(5):668-72

Institute of Lipid and Atherosclerosis Research, Sheba Medical Center, Tel Hashomer, Israel.

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May 2006

9-cis beta-carotene-rich powder of the alga Dunaliella bardawil increases plasma HDL-cholesterol in fibrate-treated patients.

Atherosclerosis 2006 Nov 18;189(1):215-21. Epub 2006 Jan 18.

The Institute of Lipid and Atherosclerosis Research, Sheba Medical Center, Tel-Hashomer and Sackler Faculty of Medicine, Tel Aviv University, Tel-Hashomer 52621, Israel.

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November 2006

Beyond guidelines: achieving the optimum in LDL cholesterol control.

Curr Opin Lipidol 2005 Dec;16(6):635-9

Department of Medicine, Wolfson Medical Center, Holon, Israel.

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December 2005

A functional role for inducible costimulator (ICOS) in atherosclerosis.

Atherosclerosis 2005 Nov 6;183(1):57-63. Epub 2005 Jun 6.

Department of Cardiology and the Cardiovascular Research Laboratory, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, 6 Weizmann St., Tel-Aviv, Israel.

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November 2005

Antigen-tailored therapy based on the inflammatory theory of atherosclerosis.

Expert Rev Vaccines 2004 Oct;3(5):605-11

Vascular Biogenics Ltd, 6, Jonathan Netanyahu St., Or Yehuda, 60376 Israel.

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October 2004

Low-dose interferon-alpha accelerates atherosclerosis in an LDL receptor-deficient mouse model.

Eur J Intern Med 2003 Dec;14(8):479-483

Department of Medicine D, Meir Medical Center, Kfar-Sava and the Sackler Faculty of Medicine, Tel-Aviv University, Kfar-Sava 44281, Israel.

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December 2003

Are triglyceride-rich lipoproteins associated with aortic valve sclerosis? A preliminary report.

Atherosclerosis 2003 Oct;170(2):301-5

Division of Epidemiology and Preventive Medicine, Sackler Medical Faculty, Tel Aviv University, and Institute of Lipid & Artherosclerosis Research, Sheba Medical Center, Tel-Hashomer, Israel.

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October 2003

Plasma lipid levels in Alzheimer's disease patients treated by Donepezil hydrochloride: a cross-sectional study.

Arch Gerontol Geriatr 2004 Jan-Feb;38(1):61-8

Department of Geriatric Medicine, Sheba Medical Center, Tel Hashomer 52621, Israel.

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June 2004

Biliary and systemic effects of fatty acid bile acid conjugates.

Eur J Gastroenterol Hepatol 2003 Jun;15(6):649-55

Minerva Centre for Cholesterol Gallstones and Lipid Metabolism in the Liver, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

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June 2003

Indices related to apo CII and CIII serum concentrations and coronary heart disease: a case-control study.

Prev Med 2003 Jul;37(1):18-22

Division of Epidemiology and Preventive Medicine, Sackler Medical Faculty, Tel Aviv University, Israel.

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July 2003

Atherogenesis inhibition induced by magnesium-chloride fortification of drinking water.

Biol Trace Elem Res 2002 ;90(1-3):251-9

Institute of Lipid and Atherosclerosis Research, Sheba Medical Center, Tel-Hashomer, and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv Israel.

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July 2003

Oral tolerance with heat shock protein 65 attenuates Mycobacterium tuberculosis-induced and high-fat-diet-driven atherosclerotic lesions.

J Am Coll Cardiol 2002 Oct;40(7):1333-8

Institute of Lipid and Atherosclerosis Research, Sheba Medical Center, Tel Hashomer, Israel.

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October 2002

Severe hyperlipidemia-associated pregnancy: prevention in subsequent pregnancy by diet.

Acta Obstet Gynecol Scand 2002 Aug;81(8):788-90

Department of Obstetrics and Gynecology, Barzilai Medical Center, Ben-Gurion University of the Negev, Ashkelon, Israel.

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August 2002

Association between serum apolipoprotein C(II) concentration and coronary heart disease.

Prev Med 2002 Jul;35(1):42-7

Division of Epidemiology and Preventive Medicine, Sackler Medical Faculty, Tel Aviv University, Israel.

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July 2002

Efficacy of atorvastatin in treating high risk patients to reach low density lipoprotein-cholesterol goals: the Treat to Target (TTT-Israel) Study.

Isr Med Assoc J 2002 Jun;4(6):407-10

Department of Internal Medicine A and Institute of Physiological Hygiene, Wolfson Medical Center, Holon, Israel.

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June 2002