Publications by authors named "Dragos C Plesca"

2 Publications

  • Page 1 of 1

Evaluation of CYP2C19 Genotype-Guided Voriconazole Prophylaxis After Allogeneic Hematopoietic Cell Transplant.

Clin Pharmacol Ther 2020 03 26;107(3):571-579. Epub 2019 Oct 26.

Department of Hematologic Oncology and Blood Disorders, Levine Cancer Institute, Atrium Health, Charlotte, North Carolina, USA.

There is a high risk of voriconazole failure in those with subtherapeutic drug concentrations, which is more common in CYP2C19 (cytochrome P450 2C19) rapid/ultrarapid metabolizers (RMs/UMs). We evaluated CYP2C19 genotype-guided voriconazole dosing on drug concentrations and clinical outcomes in adult allogeneic hematopoietic cell transplant recipients. Poor (PMs), intermediate (IMs), and normal metabolizers (NMs) received voriconazole 200 mg twice daily; RMs/UMs received 300 mg twice daily. Steady-state trough concentrations were obtained after 5 days, targeting 1.0-5.5 mg/L. Of 89 evaluable patients, 29% had subtherapeutic concentrations compared with 50% in historical controls (P < 0.001). Zero, 26%, 50%, and 16% of PMs, IMs, NMs, and RMs/UMs were subtherapeutic. Voriconazole success rate was 78% compared with 54% in historical controls (P < 0.001). No patients experienced an invasive fungal infection (IFI). Genotype-guided dosing resulted in $4,700 estimated per patient savings as compared with simulated controls. CYP2C19 genotype-guided voriconazole dosing reduced subtherapeutic drug concentrations and effectively prevented IFIs.
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http://dx.doi.org/10.1002/cpt.1642DOI Listing
March 2020

Transitioning historically inpatient chemotherapy regimens for hematologic malignancies to the ambulatory care setting.

Am J Health Syst Pharm 2018 Nov 21;75(22):1824-1830. Epub 2018 Aug 21.

Department of Pharmacy, Levine Cancer Institute, Atrium Health, Charlotte, NC.

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http://dx.doi.org/10.2146/ajhp180060DOI Listing
November 2018