Douglas Richman

Douglas Richman

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Bacteremia and Severe Cellulitis.

Open Forum Infect Dis 2019 Jul 17;6(7):ofz282. Epub 2019 Jun 17.

VA San Diego Healthcare System and Division of Infectious Diseases, University of California, San Diego, La Jolla, California.

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https://academic.oup.com/ofid/article/doi/10.1093/ofid/ofz28
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http://dx.doi.org/10.1093/ofid/ofz282DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6634436PMC
July 2019

Histone deacetylase inhibitors induce complex host responses that contribute to differential potencies of these compounds in HIV reactivation.

J Biol Chem 2019 04 11;294(14):5576-5589. Epub 2019 Feb 11.

From the Veterans Affairs San Diego Healthcare System and Veterans Medical Research Foundation, San Diego, California 92161 and.

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http://www.jbc.org/lookup/doi/10.1074/jbc.RA118.005185
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http://dx.doi.org/10.1074/jbc.RA118.005185DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6462528PMC
April 2019

A case report of disseminated histoplasmosis and concurrent cryptococcal meningitis in a patient treated with ruxolitinib.

BMC Infect Dis 2019 Mar 27;19(1):287. Epub 2019 Mar 27.

Division of Infectious Diseases, University of California San Diego, 9500 Gilman Drive, La Jolla, CA, 92093-0711, USA.

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http://dx.doi.org/10.1186/s12879-019-3922-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437885PMC
March 2019

Quantitation of Integrated HIV Provirus by Pulsed-Field Gel Electrophoresis and Droplet Digital PCR.

J Clin Microbiol 2018 12 27;56(12). Epub 2018 Nov 27.

San Diego Center for AIDS Research, University of California San Diego, La Jolla, California, USA

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http://jcm.asm.org/lookup/doi/10.1128/JCM.01158-18
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http://dx.doi.org/10.1128/JCM.01158-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6258838PMC
December 2018

Improved assays to measure and characterize the inducible HIV reservoir.

EBioMedicine 2018 Oct 11;36:113-121. Epub 2018 Oct 11.

University of California San Diego, La Jolla, CA, USA; Veterans Affairs San Diego Healthcare System, La Jolla, CA, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S23523964183039
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http://dx.doi.org/10.1016/j.ebiom.2018.09.036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197429PMC
October 2018

Effect of HIV-1 low-level viraemia during antiretroviral therapy on treatment outcomes in WHO-guided South African treatment programmes: a multicentre cohort study.

Lancet Infect Dis 2018 02 17;18(2):188-197. Epub 2017 Nov 17.

Translational Virology, Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands; Ndlovu Research Consortium, Elandsdoorn, South Africa. Electronic address:

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http://dx.doi.org/10.1016/S1473-3099(17)30681-3DOI Listing
February 2018

Factors Associated With Persistence of Plasma HIV-1 RNA During Long-term Continuously Suppressive Firstline Antiretroviral Therapy.

Open Forum Infect Dis 2018 Feb 3;5(2):ofy032. Epub 2018 Feb 3.

Institute of Infection and Global Health, University of Liverpool, Liverpool, United Kingdom.

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http://dx.doi.org/10.1093/ofid/ofy032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5825920PMC
February 2018

Mark Wainberg.

Curr Opin HIV AIDS 2017 09;12(5):423-424

aVA San Diego Healthcare System and University of California San Diego, Distinguished Professor of Pathology and Medicine, Director, Center for AIDS Research, Florence Seeley Riford Chair in AIDS Research, Room 329, Stein Clinical Sciences Building, 9500 Gilman Drive, La Jolla, CA 92093-0679. Tel: +858 552 7439; fax: +858 552 7445; e-mail: Homer & Martha Gudelsky Distinguished Professor in Medicine, Director, Institute of Human Virology, University of Maryland School of Medicine, Co-Founder & Scientific Director, Global Virus Network. Tel: +410 706 8614; fax: +410 706 1952; e-mail:

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http://dx.doi.org/10.1097/COH.0000000000000394DOI Listing
September 2017

Relative efficacy of T cell stimuli as inducers of productive HIV-1 replication in latently infected CD4 lymphocytes from patients on suppressive cART.

Virology 2017 08;508:127-133

VA San Diego Healthcare System, 3350 La Jolla Village Dr., San Diego, CA 92161, USA; University of California San Diego, 9500 Gilman Dr., La Jolla, CA 92093, USA. Electronic address:

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http://dx.doi.org/10.1016/j.virol.2017.05.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5654527PMC
August 2017

Increased HIV-1 superinfection risk in carriers of specific human leukocyte antigen alleles.

AIDS 2017 05;31(8):1149-1158

aUniversity of California San Diego, La Jolla bVeterans Affairs San Diego Healthcare System, San Diego, California, USA.

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http://dx.doi.org/10.1097/QAD.0000000000001445DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5559224PMC
May 2017

HIV persistence in tissue macrophages of humanized myeloid-only mice during antiretroviral therapy.

Nat Med 2017 May 17;23(5):638-643. Epub 2017 Apr 17.

Division of Infectious Diseases, Center for AIDS Research, University of North Carolina, School of Medicine, Chapel Hill, North Carolina, USA.

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http://dx.doi.org/10.1038/nm.4319DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5419854PMC
May 2017

2017 Update of the Drug Resistance Mutations in HIV-1.

Top Antivir Med 2017 Dec/Jan;24(4):132-133

Veterans Affairs San Diego Healthcare System and University of California San Diego, San Diego, CA, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5677049PMC
April 2017

HIV: Finding latent needles in a haystack.

Nature 2017 03 15;543(7646):499-500. Epub 2017 Mar 15.

Center for AIDS Research, University of California San Diego, La Jolla, California 92093-0679, USA, and at the Veteran Affairs San Diego Healthcare System, San Diego.

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http://dx.doi.org/10.1038/nature21899DOI Listing
March 2017

2015 Update of the Drug Resistance Mutations in HIV-1.

Top Antivir Med 2015 Oct-Nov;23(4):132-41

Veterans Affairs San Diego Healthcare System and University of California San Diego, San Diego, CA, USA.

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https://www.iasusa.org/sites/default/files/tam/23-4-132.pdf
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6148920PMC
November 2016

HIV-associated neurocognitive disorder is associated with HIV-1 dual infection.

AIDS 2016 11;30(17):2591-2597

aUniversity of California, San Diego, La Jolla, California, USA bINSERM UMR U966, Tours, France cVeterans Affairs San Diego Healthcare System, San Diego, California, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5083206PMC
http://dx.doi.org/10.1097/QAD.0000000000001237DOI Listing
November 2016

Editorial Commentary: HIV Is Putting Up Less Resistance.

Clin Infect Dis 2016 05 8;62(10):1318-9. Epub 2016 Mar 8.

Departments of Pathology and Medicine and the Center for AIDS Research, University of California VA San Diego Healthcare System.

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http://dx.doi.org/10.1093/cid/ciw130DOI Listing
May 2016

Prevalence of Transmitted HIV Drug Resistance Among Recently Infected Persons in San Diego, CA 1996-2013.

J Acquir Immune Defic Syndr 2016 Feb;71(2):228-36

*Department of Preventive and Social Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand; †Department of Medicine, University of California, San Diego, CA; ‡Veterans Affairs San Diego Healthcare System, San Diego, CA; and §Department of Pathology, University of California, San Diego, CA.

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https://insights.ovid.com/crossref?an=00126334-201602010-000
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http://dx.doi.org/10.1097/QAI.0000000000000831DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4712087PMC
February 2016

Measuring the latent reservoir in vivo.

J Clin Invest 2016 Feb 1;126(2):464-72. Epub 2016 Feb 1.

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https://www.jci.org/articles/view/80567
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http://dx.doi.org/10.1172/JCI80567DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4731179PMC
February 2016

Colorectal Disorders in Acute Human Immunodeficiency Virus Infection: A Case Series.

Open Forum Infect Dis 2016 Jan 29;3(1):ofw014. Epub 2016 Jan 29.

Departments of Medicine; Veterans Affairs San Diego Healthcare System, California, La Jolla.

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http://dx.doi.org/10.1093/ofid/ofw014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4766383PMC
January 2016

Characterizing the multiplicity of HIV founder variants during sexual transmission among MSM.

Virus Evol 2016 Jan 8;2(1):vew012. Epub 2016 Jun 8.

University of California, San Diego, 9500 Gilman Drive, Stein Clinical Research Building #325, La Jolla CA, USA.

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http://dx.doi.org/10.1093/ve/vew012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6118227PMC
January 2016

HIV: Cure by killing.

Nature 2015 Dec 2;528(7581):198-9. Epub 2015 Dec 2.

Center for AIDS Research, University of California San Diego, La Jolla, California 92093-0679, USA, and at the Veteran Affairs San Diego Healthcare System, San Diego.

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http://dx.doi.org/10.1038/nature16321DOI Listing
December 2015

Dose-responsive gene expression in suberoylanilide hydroxamic acid-treated resting CD4+ T cells.

AIDS 2015 Nov;29(17):2235-44

aDepartment of Medicine bDepartment of Pathology, University of California San Diego, La Jolla cVeterans Affairs San Diego Healthcare System, San Diego, California, USA dFaculty of Medicine, University of Southampton, Southampton, Hants, UK eDepartments of Medicine, of Epidemiology, and of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

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http://dx.doi.org/10.1097/QAD.0000000000000839DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4917679PMC
November 2015

No evidence of posttreatment control after early initiation of antiretroviral therapy.

AIDS 2015 Oct;29(16):2093-7

aUniversity of California, San Diego, La Jolla bVeterans Affairs San Diego Healthcare System, San Diego, California, USA.

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http://dx.doi.org/10.1097/QAD.0000000000000816DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4638137PMC
October 2015

During Stably Suppressive Antiretroviral Therapy Integrated HIV-1 DNA Load in Peripheral Blood is Associated with the Frequency of CD8 Cells Expressing HLA-DR/DP/DQ.

EBioMedicine 2015 Sep 21;2(9):1153-9. Epub 2015 Jul 21.

Department of Clinical Infection, Microbiology and Immunology (CIMI), Institute of Infection and Global Health (IGH), University of Liverpool, 8 West Derby Street, Liverpool L697BE, United Kingdom.

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http://dx.doi.org/10.1016/j.ebiom.2015.07.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4588402PMC
September 2015

Preface.

Curr Top Microbiol Immunol 2015 ;389:v-vii

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July 2015

Joep MA Lange.

Antivir Ther 2014 14;19(4):325-6. Epub 2014 Aug 14.

Departments of Pathology and Medicine, University of California, San Diego, CA, USA.

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http://dx.doi.org/10.3851/IMP2847DOI Listing
May 2015

2014 Update of the drug resistance mutations in HIV-1.

Top Antivir Med 2014 Jun-Jul;22(3):642-50

Veterans Affairs San Diego Healthcare System and University of California San Diego, La Jolla, CA, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4392881PMC
April 2015

Select host restriction factors are associated with HIV persistence during antiretroviral therapy.

AIDS 2015 Feb;29(4):411-20

aBlood Systems Research Institute, San Francisco bDepartment of Medicine, University of California, San Francisco, California cEmory University, Atlanta, Georgia dUniversity of California, San Diego, La Jolla eVeterans Affairs San Diego Healthcare System, San Diego fDepartment of Laboratory Medicine, University of California, San Francisco, California, USA.

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http://dx.doi.org/10.1097/QAD.0000000000000572DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4385712PMC
February 2015

Influence of the timing of antiretroviral therapy on the potential for normalization of immune status in human immunodeficiency virus 1-infected individuals.

JAMA Intern Med 2015 Jan;175(1):88-99

Veterans Affairs Research Center for AIDS and HIV-1 Infection, South Texas Veterans Health Care System, San Antonio4Veterans Affairs Center for Personalized Medicine, South Texas Veterans Health Care System, San Antonio5Department of Medicine, The Univers.

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http://dx.doi.org/10.1001/jamainternmed.2014.4010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4286496PMC
January 2015

HIV-1 neutralizing antibody response and viral genetic diversity characterized with next generation sequencing.

Virology 2015 Jan 11;474:34-40. Epub 2014 Nov 11.

University of California San Diego, 9500 Gilman Dr. 0679, La Jolla, CA 92093, USA; Veterans Affairs San Diego Healthcare System, 3350 La Jolla Village Dr., San Diego, CA, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S00426822140047
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http://dx.doi.org/10.1016/j.virol.2014.10.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4259848PMC
January 2015

Influence of age at virologic control on peripheral blood human immunodeficiency virus reservoir size and serostatus in perinatally infected adolescents.

JAMA Pediatr 2014 Dec;168(12):1138-46

Program in Molecular Medicine, Department of Pediatrics, University of Massachusetts Medical School, Worcester10Center for Clinical and Translational Science, University of Massachusetts Medical School, Worcester.

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http://dx.doi.org/10.1001/jamapediatrics.2014.1560DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4324476PMC
December 2014

Editorial overview: antivirals and resistance: advances and challenges ahead.

Curr Opin Virol 2014 Oct 22;8:iv-vii. Epub 2014 Aug 22.

VA San Diego Healthcare System and University of California San Diego, Room 329, Stein Clinical Sciences Building, 9500 Gilman Drive, La Jolla, CA 92093-0679, USA. Electronic address:

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http://dx.doi.org/10.1016/j.coviro.2014.08.002DOI Listing
October 2014

HIV migration between blood and cerebrospinal fluid or semen over time.

J Infect Dis 2014 May 2;209(10):1642-52. Epub 2013 Dec 2.

University of California-San Diego, La Jolla.

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http://dx.doi.org/10.1093/infdis/jit678DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3997580PMC
May 2014

Whole transcriptome sequencing enables discovery and analysis of viruses in archived primary central nervous system lymphomas.

PLoS One 2013 4;8(9):e73956. Epub 2013 Sep 4.

Moores Cancer Center, University of California San Diego, La Jolla, California, United States of America ; Bioinformatics and Systems Biology Graduate Program, University of California San Diego, La Jolla, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0073956PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3762708PMC
April 2014

Editorial Commentary: Extending HIV drug resistance testing to low levels of plasma viremia.

Clin Infect Dis 2014 Apr 14;58(8):1174-5. Epub 2014 Jan 14.

Veterans Affairs San Diego Healthcare System.

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http://dx.doi.org/10.1093/cid/ciu025DOI Listing
April 2014

Predictors of virologic response in persons who start antiretroviral therapy during recent HIV infection.

AIDS 2014 Mar;28(6):841-9

aUniversity of California San Diego, La Jolla bVeterans Administration San Diego Healthcare System, San Diego, California, USA.

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http://dx.doi.org/10.1097/QAD.0000000000000149DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4049563PMC
March 2014

Antibody response to Achromobacter xylosoxidans during HIV infection is associated with lower CD4 levels and increased lymphocyte activation.

Clin Vaccine Immunol 2014 Jan 30;21(1):46-50. Epub 2013 Oct 30.

Department of Psychiatry, University of California San Diego, La Jolla, California, USA.

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http://dx.doi.org/10.1128/CVI.00553-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3910916PMC
January 2014

Update of the drug resistance mutations in HIV-1: March 2013.

Top Antivir Med 2013 Feb-Mar;21(1):6-14

Birmingham Veterans Affairs Medical Center and the University of Alabama at Birmingham School of Medicine, Birmingham, AL, USA.

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http://www.matecmichigan.org/A%20Drug%20Resistance%20Mutatio
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6148891PMC
November 2013

Differential gene expression in HIV-infected individuals following ART.

Antiviral Res 2013 Nov 6;100(2):420-8. Epub 2013 Aug 6.

Fundació irsiCaixa-HIVACAT, Institut de Recerca en Ciències de la Salut Germans Trias i Pujol (IGTP), Hospital Germans Trias, Universitat Autònoma de Barcelona, 08916 Badalona, Spain; Veterans Affairs San Diego Healthcare System, San Diego, CA 92161, USA; Department of Pathology, University of California San Diego, La Jolla, CA 92093, USA.

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http://dx.doi.org/10.1016/j.antiviral.2013.07.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3899918PMC
November 2013

Absence of detectable HIV-1 viremia after treatment cessation in an infant.

N Engl J Med 2013 Nov 23;369(19):1828-35. Epub 2013 Oct 23.

From the Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore (D.P., C.Z., Y.H.C.), Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Frederick (M.P.), and the Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda (T.-W.C.) - all in Maryland; the Department of Pediatrics, University of Mississippi Medical Center, Jackson (H.G.); the University of California San Diego, La Jolla, and the Veterans Affairs San Diego Healthcare System, San Diego (M.S., D.R.); and the Department of Pediatrics, Program in Molecular Medicine, and Center for Clinical and Translational Science, University of Massachusetts Medical School, Worcester (K.L.).

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http://www.nejm.org/doi/10.1056/NEJMoa1302976
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http://dx.doi.org/10.1056/NEJMoa1302976DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3954754PMC
November 2013

A synthetic bivalent ligand of CXCR4 inhibits HIV infection.

Biochem Biophys Res Commun 2013 Jun 18;435(4):646-50. Epub 2013 May 18.

Department of Pharmacology, SUNY Upstate Cancer Research Institute, State University of New York, Syracuse, NY 13210, USA.

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http://dx.doi.org/10.1016/j.bbrc.2013.05.038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3752463PMC
June 2013

How to best measure HIV reservoirs?

Curr Opin HIV AIDS 2013 May;8(3):170-5

Department of Virology, Necker Hospital, Paris Descartes University, Paris-Sorbonne-Cité, Paris, France.

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http://dx.doi.org/10.1097/COH.0b013e32835fc619DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3763804PMC
May 2013

Cytomegalovirus DNA in semen and blood is associated with higher levels of proviral HIV DNA.

J Infect Dis 2013 Mar 28;207(6):898-902. Epub 2012 Dec 28.

University of California-San Diego, 9500 Gilman Dr, MC 0679, La Jolla, CA 92093-0679, USA.

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http://dx.doi.org/10.1093/infdis/jis777DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3571441PMC
March 2013

New assays for monitoring residual HIV burden in effectively treated individuals.

Curr Opin HIV AIDS 2013 Mar;8(2):106-10

University of California San Diego, La Jolla, California 92093-0679, USA.

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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
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http://dx.doi.org/10.1097/COH.0b013e32835d811bDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3754420PMC
March 2013

HIV downregulates interferon-stimulated genes in primary macrophages.

J Interferon Cytokine Res 2013 Feb 31;33(2):90-5. Epub 2012 Dec 31.

Department of Internal Medicine, School of Medicine, The Catholic University of Korea, Seoul, South Korea.

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http://dx.doi.org/10.1089/jir.2012.0052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3573720PMC
February 2013

Enhanced CD4+ T-cell recovery with earlier HIV-1 antiretroviral therapy.

N Engl J Med 2013 Jan;368(3):218-30

Veterans Affairs Research Center for AIDS and HIV-1 Infection, South Texas Veterans Health Care System, San Antonio, Texas, USA.

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http://dx.doi.org/10.1056/NEJMoa1110187DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3657555PMC
January 2013