Publications by authors named "Douglas R Spitz"

100Publications

Radioresistance in Glioblastoma and the Development of Radiosensitizers.

Cancers (Basel) 2020 Sep 3;12(9). Epub 2020 Sep 3.

Free Radical & Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, University of Iowa, Iowa City, IA 52242, USA.

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http://dx.doi.org/10.3390/cancers12092511DOI Listing
September 2020

Response to Ling et al. regarding "An integrated physico-chemical approach for explaining the differential impact of FLASH versus conventional dose rate irradiation on cancer and normal tissue responses".

Radiother Oncol 2020 Jun 25;147:241-242. Epub 2020 Mar 25.

Department of Radiation Oncology, University of California, Irvine, United States.

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http://dx.doi.org/10.1016/j.radonc.2020.03.001DOI Listing
June 2020

Combination Therapy with Radiation and PARP Inhibition Enhances Responsiveness to Anti-PD-1 Therapy in Colorectal Tumor Models.

Int J Radiat Oncol Biol Phys 2020 Sep 6;108(1):81-92. Epub 2020 Feb 6.

Department of Radiation Oncology, University of Iowa Hospital and Clinics, Iowa City, Iowa; Free Radical and Radiation Biology Program, Department of Radiation Oncology, University of Iowa Hospital and Clinics, Iowa City, Iowa. Electronic address:

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http://dx.doi.org/10.1016/j.ijrobp.2020.01.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7416439PMC
September 2020

Disulfiram causes selective hypoxic cancer cell toxicity and radio-chemo-sensitization via redox cycling of copper.

Free Radic Biol Med 2020 04 4;150:1-11. Epub 2020 Feb 4.

Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, Carver College of Medicine, University of Iowa, Iowa City, IA, 52242, USA. Electronic address:

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http://dx.doi.org/10.1016/j.freeradbiomed.2020.01.186DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7299833PMC
April 2020

Inhibition of CaMKII in mitochondria preserves endothelial barrier function after irradiation.

Free Radic Biol Med 2020 01 9;146:287-298. Epub 2019 Nov 9.

Abboud Cardiovascular Research Center, Division of Cardiovascular Medicine, Department of Internal Medicine, 169 Newton Rd, 4336 PBDB, University of Iowa, Iowa City, IA, 52242, USA; Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, B180 Medical Laboratories, University of Iowa, Iowa City, IA, 52242, USA; Veterans Affairs Health Care System, 601 Hwy 6 West Iowa City, IA, 52246, USA. Electronic address:

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http://dx.doi.org/10.1016/j.freeradbiomed.2019.11.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7274136PMC
January 2020

Disrupting Mitochondrial Pyruvate Uptake Directs Glutamine into the TCA Cycle away from Glutathione Synthesis and Impairs Hepatocellular Tumorigenesis.

Cell Rep 2019 09;28(10):2608-2619.e6

Department of Biochemistry, University of Iowa Carver College of Medicine, Iowa City, IA 52240, USA; Holden Comprehensive Cancer Center, University of Iowa Carver College of Medicine, Iowa City, IA 52240, USA; Fraternal Order of Eagles Diabetes Research Center (FOEDRC), University of Iowa Carver College of Medicine, Iowa City, IA 52240, USA; Abboud Cardiovascular Research Center, University of Iowa Carver College of Medicine, Iowa City, IA 52240, USA; Pappajohn Biomedical Institute, University of Iowa Carver College of Medicine, Iowa City, IA 52240, USA; FOEDRC Metabolomics Core Research Facility, University of Iowa Carver College of Medicine, Iowa City, IA 52240, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.07.098DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6746334PMC
September 2019

Linking Cancer Metabolic Dysfunction and Genetic Instability through the Lens of Iron Metabolism.

Cancers (Basel) 2019 Jul 30;11(8). Epub 2019 Jul 30.

Free Radical and Radiation Biology Program, Department of Radiation Oncology, Free Radical Metabolism and Imaging Program, Holden Comprehensive Cancer Center, The University of Iowa, Iowa City, IA 52242, USA.

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http://dx.doi.org/10.3390/cancers11081077DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6721799PMC
July 2019

The Role of Redox Dysregulation in the Effects of Prenatal Stress on Embryonic Interneuron Migration.

Cereb Cortex 2019 12;29(12):5116-5130

Department of Psychiatry, University of Iowa Carver College of Medicine, 1310 PBDB, 169 Newton Rd, Iowa City, IA, USA.

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http://dx.doi.org/10.1093/cercor/bhz052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7199998PMC
December 2019

Pharmacological Ascorbate as a Means of Sensitizing Cancer Cells to Radio-Chemotherapy While Protecting Normal Tissue.

Semin Radiat Oncol 2019 01;29(1):25-32

Free Radical and Radiation Biology Program, Department of Radiation Oncology, Iowa City, IA; Department of Surgery, Iowa City, IA; University of Iowa Carver College of Medicine, Iowa City, IA; The Holden Comprehensive Cancer Center, Iowa City, IA; Veterans Affairs Medical Center, Iowa City, IA. Electronic address:

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http://dx.doi.org/10.1016/j.semradonc.2018.10.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310038PMC
January 2019

Manipulations of Redox Metabolism for Enhancing Radiation Therapy Responses: A Historical Perspective and Novel Hypothesis.

Authors:
Douglas R Spitz

Semin Radiat Oncol 2019 01;29(1):1-5

Free Radical and Radiation Biology Program, Department of Radiation Oncology, Free Radical Metabolism and Imaging Program, Holden Comprehensive Cancer Center, B180 Medical Laboratories, Carver College of Medicine, The University of Iowa, Iowa City, IA 52242.. Electronic address:

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http://dx.doi.org/10.1016/j.semradonc.2018.10.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6709524PMC
January 2019

Persistent increase in mitochondrial superoxide mediates cisplatin-induced chronic kidney disease.

Redox Biol 2019 01 27;20:98-106. Epub 2018 Sep 27.

Division of Pediatric Nephrology, Dialysis and Transplantation, Stead Family Department of Pediatrics, The University of Iowa, Iowa City, IA, 52242, United States. Electronic address:

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http://dx.doi.org/10.1016/j.redox.2018.09.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6174865PMC
January 2019

Emerging evidence for targeting mitochondrial metabolic dysfunction in cancer therapy.

J Clin Invest 2018 08 31;128(9):3682-3691. Epub 2018 Aug 31.

Department of Radiation Oncology, Robert H. Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.

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https://www.jci.org/articles/view/120844
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http://dx.doi.org/10.1172/JCI120844DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6118595PMC
August 2018

Corrigendum to: Augmentation of intracellular iron using iron sucrose enhances the toxicity of pharmacological ascorbate in colon cancer cells [Redox Biol. (2018) 82-87].

Redox Biol 2020 Jan 8;28:100935. Epub 2018 Jun 8.

Free Radical and Radiation Biology Program, Departments of Radiation Oncology, Carver College of Medicine, Holden Comprehensive Cancer Center, The University of Iowa, Iowa City, IA 52242, United States. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22132317183048
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http://dx.doi.org/10.1016/j.redox.2018.06.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6920117PMC
January 2020

Defective protein repair under methionine sulfoxide A deletion drives autophagy and ARE-dependent gene transcription.

Redox Biol 2018 06 3;16:401-413. Epub 2018 Apr 3.

Abboud Cardiovascular Research Center, Division of Cardiovascular Medicine, Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA; Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, University of Iowa, Iowa City, IA 52242, USA; Veterans Affairs Healthcare System, Iowa City, IA 52246, USA. Electronic address:

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http://dx.doi.org/10.1016/j.redox.2018.04.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5953240PMC
June 2018

Superoxide Dismutase Mimetic GC4419 Enhances the Oxidation of Pharmacological Ascorbate and Its Anticancer Effects in an H₂O₂-Dependent Manner.

Antioxidants (Basel) 2018 Jan 19;7(1). Epub 2018 Jan 19.

Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, The University of Iowa College of Medicine, Iowa City, IA 52242, USA.

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http://dx.doi.org/10.3390/antiox7010018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5789328PMC
January 2018

Radioresistant Cervical Cancers Are Sensitive to Inhibition of Glycolysis and Redox Metabolism.

Cancer Res 2018 03 16;78(6):1392-1403. Epub 2018 Jan 16.

Department of Radiation Oncology, Washington University School of Medicine, St. Louis, Missouri.

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http://dx.doi.org/10.1158/0008-5472.CAN-17-2367DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5856626PMC
March 2018

Redox active metals and HO mediate the increased efficacy of pharmacological ascorbate in combination with gemcitabine or radiation in pre-clinical sarcoma models.

Redox Biol 2018 04 28;14:417-422. Epub 2017 Sep 28.

Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, The University of Iowa, Iowa City, IA 52242, United States. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22132317173058
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http://dx.doi.org/10.1016/j.redox.2017.09.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5651553PMC
April 2018

Augmentation of intracellular iron using iron sucrose enhances the toxicity of pharmacological ascorbate in colon cancer cells.

Redox Biol 2018 04 26;14:82-87. Epub 2017 Aug 26.

Free Radical and Radiation Biology Program, Departments of Radiation Oncology, Carver College of Medicine, Holden Comprehensive Cancer Center, The University of Iowa, Iowa City, IA 52242, United States. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22132317173064
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http://dx.doi.org/10.1016/j.redox.2017.08.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5591450PMC
April 2018

D-penicillamine combined with inhibitors of hydroperoxide metabolism enhances lung and breast cancer cell responses to radiation and carboplatin via HO-mediated oxidative stress.

Free Radic Biol Med 2017 07 5;108:354-361. Epub 2017 Apr 5.

Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, Carver College of Medicine, The University of Iowa, Iowa City, IA 52242, United States. Electronic address:

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http://dx.doi.org/10.1016/j.freeradbiomed.2017.04.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5495544PMC
July 2017

Enhancement of Radiation Response in Breast Cancer Stem Cells by Inhibition of Thioredoxin- and Glutathione-Dependent Metabolism.

Radiat Res 2016 Oct 19;186(4):385-395. Epub 2016 Sep 19.

a   Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, Carver College of Medicine, The University of Iowa, Iowa City, Iowa 52240.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5077643PMC
http://dx.doi.org/10.1667/RR14463.1DOI Listing
October 2016

Size-dependent cytotoxicity of copper oxide nanoparticles in lung epithelial cells.

Environ Sci Nano 2016 Apr 24;3(2):365-374. Epub 2016 Feb 24.

Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, University of Iowa, Iowa city, IA 52242, United States.

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http://dx.doi.org/10.1039/C5EN00271KDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4917228PMC
April 2016

Assessment of the Mitigative Capacity of Dietary Zinc on PCB126 Hepatotoxicity and the Contribution of Zinc to Toxicity.

Chem Res Toxicol 2016 05 23;29(5):851-9. Epub 2016 Mar 23.

Interdisciplinary Graduate Program in Human Toxicology, University of Iowa , Iowa City, Iowa 52242, United States.

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http://dx.doi.org/10.1021/acs.chemrestox.6b00022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5100827PMC
May 2016

James William Osborne, PhD 1928-2015.

Radiat Res 2016 Feb;185(2):214-6

Little Rock, AR.

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http://dx.doi.org/10.1667/RR0JWO.1DOI Listing
February 2016

Redox balance influences differentiation status of neuroblastoma in the presence of all-trans retinoic acid.

Redox Biol 2016 Apr 29;7:88-96. Epub 2015 Nov 29.

Department of Pharmaceutical, Social, and Administrative Sciences, Belmont University College of Pharmacy, 1900 Belmont Boulevard, Nashville, TN 37212, USA. Electronic address:

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http://dx.doi.org/10.1016/j.redox.2015.11.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4683430PMC
April 2016

Essential Components of Cancer Education.

Cancer Res 2015 Dec 1;75(24):5202-5. Epub 2015 Dec 1.

Holden Comprehensive Cancer Center, Carver College of Medicine, The University of Iowa, Iowa City, Iowa.

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http://dx.doi.org/10.1158/0008-5472.CAN-15-2077DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4681646PMC
December 2015

Disruption of thioredoxin metabolism enhances the toxicity of transforming growth factor β-activated kinase 1 (TAK1) inhibition in KRAS-mutated colon cancer cells.

Redox Biol 2015 Aug 18;5:319-327. Epub 2015 Jun 18.

Department of Surgery, Division of Surgical Oncology, University of Iowa Hospitals and Clinics, Iowa City, IA, USA; Department of Radiation Oncology, Free Radical and Radiation Biology, University of Iowa Hospitals and Clinics, Iowa City, IA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.redox.2015.06.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4491644PMC
August 2015

Pharmacological Ascorbate Radiosensitizes Pancreatic Cancer.

Cancer Res 2015 Aug 16;75(16):3314-26. Epub 2015 Jun 16.

Department of Surgery, University of Iowa College of Medicine, Iowa City, Iowa. Department of Radiation Oncology, University of Iowa College of Medicine, Iowa City, Iowa. Holden Comprehensive Cancer Center, Iowa City, Iowa. Veterans Affairs Medical Center, Iowa City, Iowa.

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http://dx.doi.org/10.1158/0008-5472.CAN-14-1707DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4537815PMC
August 2015

Biobehavioral and neuroendocrine correlates of antioxidant enzyme activity in ovarian carcinoma.

Brain Behav Immun 2015 Nov 16;50:58-62. Epub 2015 May 16.

Department of Psychology, University of Iowa, United States; Holden Comprehensive Cancer Center, University of Iowa, United States; Department of Obstetrics and Gynecology, University of Iowa, United States; Department of Urology, University of Iowa, United States. Electronic address:

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http://dx.doi.org/10.1016/j.bbi.2015.04.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4631681PMC
November 2015

Combined inhibition of glycolysis, the pentose cycle, and thioredoxin metabolism selectively increases cytotoxicity and oxidative stress in human breast and prostate cancer.

Redox Biol 2015 10;4:127-35. Epub 2014 Dec 10.

Department of Radiation Oncology, Free Radical and Radiation Biology Program, Holden Comprehensive Cancer Center, University of Iowa, Iowa City, IA 52242, USA. Electronic address:

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http://dx.doi.org/10.1016/j.redox.2014.12.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4309850PMC
June 2016

Ketogenic diets as an adjuvant cancer therapy: History and potential mechanism.

Redox Biol 2014 7;2:963-70. Epub 2014 Aug 7.

Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, University of Iowa, Iowa City, IA 52242, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S22132317140009
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http://dx.doi.org/10.1016/j.redox.2014.08.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4215472PMC
January 2018

Retroviral-infection increases tumorigenic potential of MDA-MB-231 breast carcinoma cells by expanding an aldehyde dehydrogenase (ALDH1) positive stem-cell like population.

Redox Biol 2014 24;2:847-54. Epub 2014 Jun 24.

Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, Carver College of Medicine, University of Iowa, Iowa City, IA 52240, United States.

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http://dx.doi.org/10.1016/j.redox.2014.06.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4085353PMC
January 2015

Reactive oxygen species in normal and tumor stem cells.

Adv Cancer Res 2014 ;122:1-67

Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, Carver College of Medicine, The University of Iowa, Iowa City, Iowa, USA. Electronic address:

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http://dx.doi.org/10.1016/B978-0-12-420117-0.00001-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207279PMC
February 2015

Mitochondrial calcium uniporter activity is dispensable for MDA-MB-231 breast carcinoma cell survival.

PLoS One 2014 6;9(5):e96866. Epub 2014 May 6.

Department of Internal Medicine, Division of Cardiovascular Medicine, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States of America; Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States of America; Department of Molecular Physiology and Biophysics, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0096866PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4011874PMC
June 2015

The absence of CpG in plasmid DNA-chitosan polyplexes enhances transfection efficiencies and reduces inflammatory responses in murine lungs.

Mol Pharm 2014 Mar 4;11(3):1022-31. Epub 2014 Feb 4.

Division of Pharmaceutics and Translational Therapeutics, College of Pharmacy, ‡Department of Occupational and Environmental Health, College of Public Health, and §Department of Radiation Oncology, Carver College of Medicine, University of Iowa , Iowa City, Iowa 52242, United States.

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http://dx.doi.org/10.1021/mp400689rDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3993893PMC
March 2014

Ionizing radiation-induced responses: where free radical chemistry meets redox biology and medicine.

Antioxid Redox Signal 2014 Mar 11;20(9):1407-9. Epub 2014 Feb 11.

1 Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, The University of Iowa , Iowa City, Iowa.

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http://dx.doi.org/10.1089/ars.2013.5769DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3936498PMC
March 2014

Maintenance of mitochondrial genomic integrity in the absence of manganese superoxide dismutase in mouse liver hepatocytes.

Redox Biol 2013 5;1:172-7. Epub 2013 Feb 5.

Free Radical and Radiation Biology Program, Department of Radiation Oncology, Carver College of Medicine and the Holden Comprehensive Cancer Center, The University of Iowa, Iowa City, IA 52242, USA.

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http://dx.doi.org/10.1016/j.redox.2013.01.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757676PMC
May 2015

Chitosan coating of copper nanoparticles reduces in vitro toxicity and increases inflammation in the lung.

Nanotechnology 2013 Oct 5;24(39):395101. Epub 2013 Sep 5.

Department of Chemical and Biochemical Engineering, College of Engineering, University of Iowa, Iowa City, IA 52242, USA. Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, University of Iowa, Iowa City, IA 52242, USA.

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http://dx.doi.org/10.1088/0957-4484/24/39/395101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3816956PMC
October 2013

A new player in environmentally induced oxidative stress: polychlorinated biphenyl congener, 3,3'-dichlorobiphenyl (PCB11).

Toxicol Sci 2013 Nov 31;136(1):39-50. Epub 2013 Aug 31.

* Free Radical and Radiation Biology Program, B180 Medical Laboratories, Department of Radiation Oncology, Holden Comprehensive Cancer Center.

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http://dx.doi.org/10.1093/toxsci/kft186DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3829572PMC
November 2013

Superoxide mediates acute liver injury in irradiated mice lacking sirtuin 3.

Antioxid Redox Signal 2014 Mar 28;20(9):1423-35. Epub 2013 Sep 28.

1 Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, Carver College of Medicine, The University of Iowa , Iowa City, Iowa.

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http://dx.doi.org/10.1089/ars.2012.5091DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3936509PMC
March 2014

Low-dose radiation-induced enhancement of thymic lymphomagenesis in Lck-Bax mice is dependent on LET and gender.

Radiat Res 2013 Aug 2;180(2):156-65. Epub 2013 Jul 2.

Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, University of Iowa, Iowa City, Iowa 52242, USA.

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http://dx.doi.org/10.1667/RR3293.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3821998PMC
August 2013

Selenoprotein P regulates 1-(4-Chlorophenyl)-benzo-2,5-quinone-induced oxidative stress and toxicity in human keratinocytes.

Free Radic Biol Med 2013 Dec 11;65:70-77. Epub 2013 Jun 11.

Free Radical and Radiation Biology Division, Department of Radiation Oncology, The University of Iowa, Iowa City, IA 52242, USA. Electronic address:

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http://dx.doi.org/10.1016/j.freeradbiomed.2013.06.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3830697PMC
December 2013

Ketogenic diets enhance oxidative stress and radio-chemo-therapy responses in lung cancer xenografts.

Clin Cancer Res 2013 Jul 6;19(14):3905-13. Epub 2013 Jun 6.

Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, The University of Iowa, Iowa City, Iowa 52242, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-12-0287DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3954599PMC
July 2013

Breast cancer stem cell-like cells are more sensitive to ionizing radiation than non-stem cells: role of ATM.

PLoS One 2012 21;7(11):e50423. Epub 2012 Nov 21.

Department of Surgery, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0050423PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3503893PMC
May 2013

Exploring the electrostatic repulsion model in the role of Sirt3 in directing MnSOD acetylation status and enzymatic activity.

Free Radic Biol Med 2012 Aug 23;53(4):828-33. Epub 2012 Jun 23.

Department of Cancer Biology, and Vanderbilt University Medical Center, Vanderbilt University, Nashville, TN 37232, USA.

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http://dx.doi.org/10.1016/j.freeradbiomed.2012.06.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3418453PMC
August 2012

Inhibition of fatty acid oxidation enhances oxidative protein folding and protects hepatocytes from endoplasmic reticulum stress.

Mol Biol Cell 2012 Mar 19;23(5):811-9. Epub 2012 Jan 19.

Department of Anatomy and Cell Biology and Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA.

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http://dx.doi.org/10.1091/mbc.E11-12-1011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3290641PMC
March 2012

Mitochondrial Rac1 GTPase import and electron transfer from cytochrome c are required for pulmonary fibrosis.

J Biol Chem 2012 Jan 8;287(5):3301-12. Epub 2011 Dec 8.

Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, Iowa 52242, USA.

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http://dx.doi.org/10.1074/jbc.M111.308387DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3270985PMC
January 2012

Simultaneous inhibition of glutathione- and thioredoxin-dependent metabolism is necessary to potentiate 17AAG-induced cancer cell killing via oxidative stress.

Free Radic Biol Med 2012 Jan 4;52(2):436-43. Epub 2011 Nov 4.

Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, The University of Iowa, Iowa City, IA 52240, USA.

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http://dx.doi.org/10.1016/j.freeradbiomed.2011.10.493DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3664944PMC
January 2012

Genomic instability induced by mutant succinate dehydrogenase subunit D (SDHD) is mediated by O2(-•) and H2O2.

Free Radic Biol Med 2012 Jan 19;52(1):160-6. Epub 2011 Oct 19.

Department of Radiation Oncology, Holden Comprehensive Cancer Center, The University of Iowa, Iowa City, IA 52242, USA.

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http://dx.doi.org/10.1016/j.freeradbiomed.2011.10.435DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3249516PMC
January 2012

Sirt3, mitochondrial ROS, ageing, and carcinogenesis.

Int J Mol Sci 2011 23;12(9):6226-39. Epub 2011 Sep 23.

Department of Cancer Biology, Pediatrics, and Radiation Oncology, Vanderbilt University Medical Center, Nashville, TN 37232, USA; E-Mails: (S.-H.P.); (O.O.); (H.J.); (Y.I.C.); (J.D.P.); (D.G.).

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3189778PMC
February 2015

Manipulation of cellular redox parameters for improving therapeutic responses in B-cell lymphoma and multiple myeloma.

J Cell Biochem 2012 Feb;113(2):419-25

Free Radical and Radiation Biology Program, Department of Radiation Oncology, The Holden Comprehensive Cancer Center, University of Iowa, Iowa City, Iowa 52242, USA.

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http://dx.doi.org/10.1002/jcb.23387DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3374635PMC
February 2012

Enhancement of carboplatin-mediated lung cancer cell killing by simultaneous disruption of glutathione and thioredoxin metabolism.

Clin Cancer Res 2011 Oct 15;17(19):6206-17. Epub 2011 Aug 15.

Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, University of Iowa, Iowa City, Iowa 52242, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-11-0736DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3186854PMC
October 2011

An inhibitor of K+ channels modulates human endometrial tumor-initiating cells.

Cancer Cell Int 2011 Aug 2;11(1):25. Epub 2011 Aug 2.

Department of Obstetrics and Gynecology, University of Iowa, 200 Hawkins Drive, Iowa City, IA 52242, USA.

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http://dx.doi.org/10.1186/1475-2867-11-25DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3175438PMC
August 2011

Erlotinib-mediated inhibition of EGFR signaling induces metabolic oxidative stress through NOX4.

Cancer Res 2011 Jun 11;71(11):3932-40. Epub 2011 Apr 11.

Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, The University of Iowa, Iowa City, Iowa 52242, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-10-3425DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3217301PMC
June 2011

Comment on "Pharmacologic ascorbate synergizes with gemcitabine in preclinical models of pancreatic cancer," i.e., all we are saying is, give C a chance.

Free Radic Biol Med 2011 Jun 1;50(12):1726-7. Epub 2011 Apr 1.

Free Radical and Radiation Biology Graduate Program, Department of Surgery, The University of Iowa College of Medicine, Iowa City, IA 52242, USA.

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http://dx.doi.org/10.1016/j.freeradbiomed.2011.03.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3128375PMC
June 2011

Mitochondrial Cu,Zn-superoxide dismutase mediates pulmonary fibrosis by augmenting H2O2 generation.

J Biol Chem 2011 Apr 10;286(17):15597-607. Epub 2011 Mar 10.

Department of Internal Medicine, Carver College of Medicine,University of Iowa, Iowa City, Iowa 52242, USA.

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http://dx.doi.org/10.1074/jbc.M110.187377DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3083152PMC
April 2011

Acetylation of MnSOD directs enzymatic activity responding to cellular nutrient status or oxidative stress.

Aging (Albany NY) 2011 Feb;3(2):102-7

Departments of Cancer Biology, Pediatrics, and Radiation Oncology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3082006PMC
http://dx.doi.org/10.18632/aging.100291DOI Listing
February 2011

Dexamethasone-induced oxidative stress enhances myeloma cell radiosensitization while sparing normal bone marrow hematopoiesis.

Neoplasia 2010 Dec;12(12):980-92

Free Radical and Radiation Biology Program, Department of Radiation Oncology, The Holden Comprehensive Cancer Center, University of Iowa, Iowa City, IA 52242-1181, USA.

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http://dx.doi.org/10.1593/neo.101146DOI Listing
December 2010

Elevated mitochondrial superoxide disrupts normal T cell development, impairing adaptive immune responses to an influenza challenge.

Free Radic Biol Med 2011 Feb 2;50(3):448-58. Epub 2010 Dec 2.

Free Radical and Radiation Biology Program, Department of Radiation Oncology, Carver College of Medicine, Holden Comprehensive Cancer Center, The University of Iowa, Iowa City, IA 52242, USA.

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http://dx.doi.org/10.1016/j.freeradbiomed.2010.11.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3026081PMC
February 2011

Transgenic biosynthesis of trypanothione protects Escherichia coli from radiation-induced toxicity.

Radiat Res 2010 Sep;174(3):290-6

Department of Radiation Oncology, Carver College of Medicine, and Holden Comprehensive Cancer Center, The University of Iowa Free Radical and Radiation Biology Program, Montevideo, Uruguay.

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http://dx.doi.org/10.1667/RR2235.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2942016PMC
September 2010

Disruption of Sag/Rbx2/Roc2 induces radiosensitization by increasing ROS levels and blocking NF-kappaB activation in mouse embryonic stem cells.

Free Radic Biol Med 2010 Sep 8;49(6):976-83. Epub 2010 Jun 8.

Division of Radiation and Cancer Biology, Department of Radiation Oncology, University of Michigan, Ann Arbor, MI 48109, USA.

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http://dx.doi.org/10.1016/j.freeradbiomed.2010.05.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2921456PMC
September 2010

Superoxide Enhances the Antitumor Combination of AdMnSOD Plus BCNU in Breast Cancer.

Cancers (Basel) 2010 Feb;2(1):68-87

Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, Iowa City, Iowa.

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http://dx.doi.org/10.3390/cancers2010068DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2880814PMC
February 2010

2-deoxy-D-glucose induces oxidative stress and cell killing in human neuroblastoma cells.

Cancer Biol Ther 2010 Jun 26;9(11):853-61. Epub 2010 Jun 26.

Free Radical and Radiation Biology Program, Department of Radiation Oncology and Division of Hematology and Oncology, Department of Pediatrics, Holden Comprehensive Cancer Center, University of Iowa Carver College of Medicine, Iowa City, IA, USA.

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http://dx.doi.org/10.4161/cbt.9.11.11632DOI Listing
June 2010

Polychlorinated biphenyl induced ROS signaling delays the entry of quiescent human breast epithelial cells into the proliferative cycle.

Free Radic Biol Med 2010 Jul 20;49(1):40-9. Epub 2010 Mar 20.

Free Radical and Radiation Biology Program, Department of Radiation Oncology, University of Iowa, Iowa City, Iowa 52242-1181, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2875331PMC
July 2010

Liposomal doxorubicin increases radiofrequency ablation-induced tumor destruction by increasing cellular oxidative and nitrative stress and accelerating apoptotic pathways.

Radiology 2010 Apr 16;255(1):62-74. Epub 2010 Feb 16.

Laboratory for Minimally Invasive Tumor Therapies, Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Ave, Boston, MA 02215, USA.

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http://dx.doi.org/10.1148/radiol.09091196DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2843831PMC
April 2010

Paclitaxel combined with inhibitors of glucose and hydroperoxide metabolism enhances breast cancer cell killing via H2O2-mediated oxidative stress.

Free Radic Biol Med 2010 Apr 18;48(8):1024-33. Epub 2010 Jan 18.

Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, The University of Iowa, Iowa City, IA 52242, USA.

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http://dx.doi.org/10.1016/j.freeradbiomed.2010.01.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2843822PMC
April 2010

The generation of stable oxidative stress-resistant phenotypes in Chinese hamster fibroblasts chronically exposed to hydrogen peroxide or hyperoxia.

Methods Mol Biol 2010 ;610:183-99

Department of Radiation Oncology, Holden Comprehensive Cancer Center, The University of Iowa, Iowa City, IA, USA.

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February 2010