Publications by authors named "Douglas R Houston"

34Publications

Design of drug-like hepsin inhibitors against prostate cancer and kidney stones.

Acta Pharm Sin B 2020 Jul 28;10(7):1309-1320. Epub 2019 Sep 28.

University of Edinburgh, Institute of Quantitative Biology, Biochemistry and Biotechnology, Edinburgh, Scotland, EH9 3BF, UK.

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http://dx.doi.org/10.1016/j.apsb.2019.09.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7452031PMC
July 2020

PRL3-DDX21 Transcriptional Control of Endolysosomal Genes Restricts Melanocyte Stem Cell Differentiation.

Dev Cell 2020 Aug 10;54(3):317-332.e9. Epub 2020 Jul 10.

MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Crewe Road South, Edinburgh EH4 2XU, UK; Cancer Research UK Edinburgh Centre, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK. Electronic address:

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http://dx.doi.org/10.1016/j.devcel.2020.06.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7435699PMC
August 2020

Recognition Dynamics of Cancer Mutations on the ERp57-Tapasin Interface.

Cancers (Basel) 2020 Mar 20;12(3). Epub 2020 Mar 20.

International Centre for Cancer Vaccine Science, University of Gdansk, Wita Stwosza 63, 80-308 Gdansk, Poland.

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http://dx.doi.org/10.3390/cancers12030737DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7140079PMC
March 2020

Lamin A molecular compression and sliding as mechanisms behind nucleoskeleton elasticity.

Nat Commun 2019 07 11;10(1):3056. Epub 2019 Jul 11.

Wellcome Centre for Cell Biology, University of Edinburgh, Max Born Crescent, Edinburgh, EH9 3BF, UK.

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http://dx.doi.org/10.1038/s41467-019-11063-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6624373PMC
July 2019

Intrinsic lipid binding activity of ATG16L1 supports efficient membrane anchoring and autophagy.

EMBO J 2019 05 1;38(9). Epub 2019 Apr 1.

Cancer Research UK Edinburgh Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK

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http://dx.doi.org/10.15252/embj.2018100554DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6484409PMC
May 2019

An inter-subunit protein-peptide interface that stabilizes the specific activity and oligomerization of the AAA+ chaperone Reptin.

J Proteomics 2019 05 9;199:89-101. Epub 2019 Mar 9.

University of Edinburgh, Institute of Quantitative Biology, Biochemistry and Biotechnology, Edinburgh, Scotland EH9 3BF, United Kingdom.

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https://linkinghub.elsevier.com/retrieve/pii/S18743919193006
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http://dx.doi.org/10.1016/j.jprot.2019.02.012DOI Listing
May 2019

Oligopeptide Signaling through TbGPR89 Drives Trypanosome Quorum Sensing.

Cell 2019 01 29;176(1-2):306-317.e16. Epub 2018 Nov 29.

Institute for Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3FL, UK. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2018.10.041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333907PMC
January 2019

ALDH1 Bio-activates Nifuroxazide to Eradicate ALDH Melanoma-Initiating Cells.

Cell Chem Biol 2018 12 4;25(12):1456-1469.e6. Epub 2018 Oct 4.

MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XR, UK; Cancer Research UK Edinburgh Centre, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XR, UK. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S24519456183030
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http://dx.doi.org/10.1016/j.chembiol.2018.09.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6309505PMC
December 2018

Fatty-acylation target sequence in the ligand-binding domain of vertebrate steroid receptors demarcates evolution from estrogen-related receptors.

J Steroid Biochem Mol Biol 2018 11 17;184:20-28. Epub 2018 Jul 17.

School of Biological Sciences, University of Edinburgh, King's Buildings, Edinburgh EH9 3BF, UK. Electronic address:

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http://dx.doi.org/10.1016/j.jsbmb.2018.07.010DOI Listing
November 2018

Development of Potent Inhibitors of Receptor Tyrosine Kinases by Ligand-Based Drug Design and Target-Biased Phenotypic Screening.

J Med Chem 2018 03 21;61(5):2104-2110. Epub 2018 Feb 21.

Cancer Research UK Edinburgh Centre, MRC Institute of Genetics and Molecular Medicine , University of Edinburgh , Crewe Road South , Edinburgh EH4 2XR , U.K.

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http://pubs.acs.org/doi/10.1021/acs.jmedchem.7b01605
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http://dx.doi.org/10.1021/acs.jmedchem.7b01605DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5851644PMC
March 2018

Mono-Substituted Hydrocarbon Diastereomer Combinations Reveal Stapled Peptides with High Structural Fidelity.

Chemistry 2018 Feb 19;24(9):2094-2097. Epub 2018 Jan 19.

EaStChem School of Chemistry, University of Edinburgh, David Brewster Road, Edinburgh, EH9 3FJ, UK.

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http://dx.doi.org/10.1002/chem.201705983DOI Listing
February 2018

Novel triazolothiadiazines act as potent anticancer agents in liver cancer cells through Akt and ASK-1 proteins.

Bioorg Med Chem 2016 Feb 8;24(4):858-72. Epub 2016 Jan 8.

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Hacettepe University, Sıhhiye, 06100 Ankara, Turkey. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2016.01.013DOI Listing
February 2016

Identification and activity of inhibitors of the essential nematode-specific metalloprotease DPY-31.

Bioorg Med Chem Lett 2015 Dec 3;25(24):5752-5. Epub 2015 Nov 3.

Institute of Biodiversity, Animal Health & Comparative Medicine, University of Glasgow, Bearsden Road, Glasgow G61 1QH, UK.

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http://dx.doi.org/10.1016/j.bmcl.2015.10.077DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4658336PMC
December 2015

Hetero-trans-β-glucanase, an enzyme unique to Equisetum plants, functionalizes cellulose.

Plant J 2015 Sep;83(5):753-69

The Edinburgh Cell Wall Group, Institute of Molecular Plant Sciences, The University of Edinburgh, Edinburgh, EH9 3BF, UK.

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http://dx.doi.org/10.1111/tpj.12935DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4950035PMC
September 2015

Inhibition of the ERCC1-XPF structure-specific endonuclease to overcome cancer chemoresistance.

DNA Repair (Amst) 2015 Jul 22;31:19-28. Epub 2015 Apr 22.

MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, MRC Human Genetics Unit, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK. Electronic address:

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http://dx.doi.org/10.1016/j.dnarep.2015.04.002DOI Listing
July 2015

Structure- and ligand-based virtual screening identifies new scaffolds for inhibitors of the oncoprotein MDM2.

PLoS One 2015 17;10(4):e0121424. Epub 2015 Apr 17.

Institute of Structural and Molecular Biology, University of Edinburgh, Edinburgh, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0121424PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4401541PMC
January 2016

Structural Basis for the Inverted Repeat Preferences of mariner Transposases.

J Biol Chem 2015 May 13;290(21):13531-40. Epub 2015 Apr 13.

Institute of Structural and Molecular Biology, School of Biological Sciences, University of Edinburgh, The King's Buildings, Max Born Crescent, Edinburgh EH9 3BF, Scotland, United Kingdom

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http://dx.doi.org/10.1074/jbc.M115.636704DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505599PMC
May 2015

Consensus docking: improving the reliability of docking in a virtual screening context.

J Chem Inf Model 2013 Feb 7;53(2):384-90. Epub 2013 Feb 7.

Institute of Structural and Molecular Biology, University of Edinburgh, Edinburgh, United Kingdom.

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http://dx.doi.org/10.1021/ci300399wDOI Listing
February 2013

Crystal structures of antibiotic-bound complexes of aminoglycoside 2''-phosphotransferase IVa highlight the diversity in substrate binding modes among aminoglycoside kinases.

Biochemistry 2011 Jul 27;50(28):6237-44. Epub 2011 Jun 27.

Department of Biochemistry, Groupe de Recherche Axé sur la Structure des Protéines, McGill University, 3649 Promenade Sir William Osler, Montreal, Quebec H3G 0B1, Canada.

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http://dx.doi.org/10.1021/bi200747fDOI Listing
July 2011

Identification and characterization of a protein-tyrosine phosphatase in Leishmania: Involvement in virulence.

J Biol Chem 2006 Nov 27;281(47):36257-68. Epub 2006 Sep 27.

Department of Microbiology & Immunology, Mcgill University, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1074/jbc.M606256200DOI Listing
November 2006

Specificity and affinity of natural product cyclopentapeptide inhibitors against A. fumigatus, human, and bacterial chitinases.

Chem Biol 2005 Jan;12(1):65-76

Division of Biological Chemistry & Molecular Microbiology, School of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland.

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http://dx.doi.org/10.1016/j.chembiol.2004.10.013DOI Listing
January 2005

Crystal structure and binding properties of the Serratia marcescens chitin-binding protein CBP21.

J Biol Chem 2005 Mar 8;280(12):11313-9. Epub 2004 Dec 8.

Department of Chemistry, Biotechnology, and Food Science, Postbox 5003, Agricultural University of Norway, N-1432 As, Norway.

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http://dx.doi.org/10.1074/jbc.M407175200DOI Listing
March 2005

Structure-based exploration of cyclic dipeptide chitinase inhibitors.

J Med Chem 2004 Nov;47(23):5713-20

Division of Biological Chemistry and Molecular Microbiology, School of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, UK.

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http://dx.doi.org/10.1021/jm049940aDOI Listing
November 2004

Structure of the D142N mutant of the family 18 chitinase ChiB from Serratia marcescens and its complex with allosamidin.

Biochim Biophys Acta 2004 Jan;1696(1):103-11

Department of Chemistry and Biotechnology, Agricultural University of Norway, PO Box 5040, N-1432 Aas, Norway.

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http://dx.doi.org/10.1016/j.bbapap.2003.09.014DOI Listing
January 2004

Interactions of a family 18 chitinase with the designed inhibitor HM508 and its degradation product, chitobiono-delta-lactone.

J Biol Chem 2004 Jan 3;279(5):3612-9. Epub 2003 Nov 3.

Department of Chemistry and Biotechnology, Agricultural University of Norway, N-1432 As, Norway.

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http://dx.doi.org/10.1074/jbc.M310057200DOI Listing
January 2004

Structure and ligand-induced conformational change of the 39-kDa glycoprotein from human articular chondrocytes.

J Biol Chem 2003 Aug 29;278(32):30206-12. Epub 2003 May 29.

Division of Biological Chemistry & Molecular Microbiology, School of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M303371200
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http://dx.doi.org/10.1074/jbc.M303371200DOI Listing
August 2003

Crystal structures of allosamidin derivatives in complex with human macrophage chitinase.

J Biol Chem 2003 May 14;278(22):20110-6. Epub 2003 Mar 14.

Division of Biological Chemistry and Molecular Microbiology, School of Life Sciences, University of Dundee, Scotland.

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http://dx.doi.org/10.1074/jbc.M300362200DOI Listing
May 2003

The cyclic dipeptide CI-4 [cyclo-(l-Arg-d-Pro)] inhibits family 18 chitinases by structural mimicry of a reaction intermediate.

Biochem J 2002 Nov;368(Pt 1):23-7

Division of Biological Chemistry and Molecular Microbiology, School of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, U.K.

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http://dx.doi.org/10.1042/BJ20021034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1222990PMC
November 2002