Publications by authors named "Douglas R Higgs"

100Publications

Loss of Extreme Long-Range Enhancers in Human Neural Crest Drives a Craniofacial Disorder.

Cell Stem Cell 2020 Sep 22. Epub 2020 Sep 22.

Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305, USA; Institute of Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA; Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2020.09.001DOI Listing
September 2020

Enhancer-promoter interactions and transcription.

Authors:
Douglas R Higgs

Nat Genet 2020 05;52(5):470-471

MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1038/s41588-020-0620-7DOI Listing
May 2020

A Dynamic Folded Hairpin Conformation Is Associated with α-Globin Activation in Erythroid Cells.

Cell Rep 2020 02;30(7):2125-2135.e5

Dipartimento di Fisica, Università degli Studi di Napoli Federico II, and INFN Napoli, Complesso Universitario di Monte Sant'Angelo, 80126 Naples, Italy; Berlin Institute of Health (BIH), MDC-Berlin, 13125 Berlin, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2020.01.044DOI Listing
February 2020

A revised model for promoter competition based on multi-way chromatin interactions at the α-globin locus.

Nat Commun 2019 11 27;10(1):5412. Epub 2019 Nov 27.

MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1038/s41467-019-13404-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6881440PMC
November 2019

Single-Cell Proteomics Reveal that Quantitative Changes in Co-expressed Lineage-Specific Transcription Factors Determine Cell Fate.

Cell Stem Cell 2019 05 14;24(5):812-820.e5. Epub 2019 Mar 14.

Sprott Center for Stem Cell Research, Ottawa Hospital Research Institute, Ottawa, ON K1H8L6, Canada; Department of Medicine, Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON K1H8L6, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2019.02.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6886472PMC
May 2019

Potential new approaches to the management of the Hb Bart's hydrops fetalis syndrome: the most severe form of α-thalassemia.

Hematology Am Soc Hematol Educ Program 2018 11;2018(1):353-360

Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, United Kingdom.

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http://dx.doi.org/10.1182/asheducation-2018.1.353DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6246003PMC
November 2018

How to Tackle Challenging ChIP-Seq, with Long-Range Cross-Linking, Using ATRX as an Example.

Methods Mol Biol 2018 ;1832:105-130

Medical Research Council (MRC) Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, OX3 9DS, UK.

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http://link.springer.com/10.1007/978-1-4939-8663-7_6
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http://dx.doi.org/10.1007/978-1-4939-8663-7_6DOI Listing
April 2019

Molecular Basis and Genetic Modifiers of Thalassemia.

Hematol Oncol Clin North Am 2018 04;32(2):177-191

Molecular Hematology Unit, Medical Research Council (MRC), Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford OX3 9DS, UK; National Institute for Health Research, Oxford Biomedical Research Centre, Blood Theme, Oxford University Hospitals, Headington, Oxford OX3 9DU, UK. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S08898588173019
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http://dx.doi.org/10.1016/j.hoc.2017.11.003DOI Listing
April 2018

Phenotypic and molecular characterization of a serum-free miniature erythroid differentiation system suitable for high-throughput screening and single-cell assays.

Exp Hematol 2018 04 9;60:10-20. Epub 2018 Jan 9.

Medical Research Council (MRC) Molecular Hematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford, United Kingdom; Oxford National Institute for Health Research Biomedical Research Centre, Blood Theme, Oxford University Hospital, John Radcliffe Hospital, Headington, Oxford, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.exphem.2018.01.001DOI Listing
April 2018

Robust detection of chromosomal interactions from small numbers of cells using low-input Capture-C.

Nucleic Acids Res 2017 Dec;45(22):e184

Medical Research Council (MRC) Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK.

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http://dx.doi.org/10.1093/nar/gkx1194DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5728395PMC
December 2017

Between form and function: the complexity of genome folding.

Hum Mol Genet 2017 10;26(R2):R208-R215

MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, OX3 9DS, UK.

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http://dx.doi.org/10.1093/hmg/ddx306DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5886466PMC
October 2017

DNA methylation of intragenic CpG islands depends on their transcriptional activity during differentiation and disease.

Proc Natl Acad Sci U S A 2017 09 21;114(36):E7526-E7535. Epub 2017 Aug 21.

Division of Medical Sciences and Graduate Entry Medicine, School of Medicine, University of Nottingham, Royal Derby Hospital, Derby DE22 3DT, United Kingdom;

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http://dx.doi.org/10.1073/pnas.1703087114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5594649PMC
September 2017

How best to identify chromosomal interactions: a comparison of approaches.

Nat Methods 2017 01;14(2):125-134

Medical Research Council (MRC) Molecular Hematology Unit, Weatherall Institute of Molecular Medicine, Oxford University, Oxford, United Kingdom.

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http://dx.doi.org/10.1038/nmeth.4146DOI Listing
January 2017

An international registry of survivors with Hb Bart's hydrops fetalis syndrome.

Blood 2017 03 5;129(10):1251-1259. Epub 2017 Jan 5.

Medical Research Council Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom; and.

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http://dx.doi.org/10.1182/blood-2016-08-697110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5345731PMC
March 2017

Selective silencing of α-globin by the histone demethylase inhibitor IOX1: a potentially new pathway for treatment of β-thalassemia.

Haematologica 2017 03 3;102(3):e80-e84. Epub 2016 Nov 3.

Medical Research Council (MRC) Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, UK

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http://dx.doi.org/10.3324/haematol.2016.155655DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5394973PMC
March 2017

MicroRNAs of the miR-290-295 Family Maintain Bivalency in Mouse Embryonic Stem Cells.

Stem Cell Reports 2016 05 14;6(5):635-642. Epub 2016 Apr 14.

Lymphocyte Development Group, MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College London, Du Cane Road, London W12 0NN, UK; Epigenetics Section, MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College London, Du Cane Road, London W12 0NN, UK. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2016.03.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4939759PMC
May 2016

Krüppeling erythropoiesis: an unexpected broad spectrum of human red blood cell disorders due to KLF1 variants.

Blood 2016 Apr 22;127(15):1856-62. Epub 2016 Feb 22.

Department of Cell Biology, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1182/blood-2016-01-694331DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4832505PMC
April 2016

Understanding α-globin gene regulation and implications for the treatment of β-thalassemia.

Ann N Y Acad Sci 2016 03 22;1368(1):16-24. Epub 2015 Dec 22.

Medical Research Council (MRC) Molecular Hematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom.

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http://dx.doi.org/10.1111/nyas.12988DOI Listing
March 2016

Studying epigenomics in single cells: what is feasible and what can we learn?

Epigenomics 2015 8;7(8):1231-4. Epub 2015 Dec 8.

Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DS, UK.

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http://dx.doi.org/10.2217/epi.15.93DOI Listing
October 2016

Multiplexed analysis of chromosome conformation at vastly improved sensitivity.

Nat Methods 2016 Jan 23;13(1):74-80. Epub 2015 Nov 23.

Medical Research Council, Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, Oxford University, Oxford, UK.

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http://dx.doi.org/10.1038/nmeth.3664DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4724891PMC
January 2016

Suppression of the alternative lengthening of telomere pathway by the chromatin remodelling factor ATRX.

Nat Commun 2015 Jul 6;6:7538. Epub 2015 Jul 6.

MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DS, UK.

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http://www.nature.com/articles/ncomms8538
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http://dx.doi.org/10.1038/ncomms8538DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4501375PMC
July 2015

α-Globin as a molecular target in the treatment of β-thalassemia.

Blood 2015 Jun 13;125(24):3694-701. Epub 2015 Apr 13.

Medical Research Council Molecular Hematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom; Oxford National Institute for Health Research Biomedical Research Centre, Blood Theme, Oxford University Hospital, Oxford, United Kingdom.

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http://dx.doi.org/10.1182/blood-2015-03-633594DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4497969PMC
June 2015

ATRX Plays a Key Role in Maintaining Silencing at Interstitial Heterochromatic Loci and Imprinted Genes.

Cell Rep 2015 Apr 9;11(3):405-18. Epub 2015 Apr 9.

MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.03.036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4410944PMC
April 2015

Considerations when investigating lncRNA function in vivo.

Elife 2014 Aug 14;3:e03058. Epub 2014 Aug 14.

Chris P Ponting is in the MRC Functional Genomics Unit, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom; Wellcome Trust Sanger Institute, Cambridge, United Kingdom

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4132285PMC
http://dx.doi.org/10.7554/eLife.03058DOI Listing
August 2014

ATRX dysfunction induces replication defects in primary mouse cells.

PLoS One 2014 20;9(3):e92915. Epub 2014 Mar 20.

MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0092915PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3961441PMC
November 2014

Analysis of hundreds of cis-regulatory landscapes at high resolution in a single, high-throughput experiment.

Nat Genet 2014 Feb 12;46(2):205-12. Epub 2014 Jan 12.

Medical Research Council (MRC) Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, Oxford University, Oxford, UK.

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http://dx.doi.org/10.1038/ng.2871DOI Listing
February 2014

The chromatin remodeller ATRX: a repeat offender in human disease.

Trends Biochem Sci 2013 Sep 1;38(9):461-6. Epub 2013 Aug 1.

MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DS, UK.

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http://dx.doi.org/10.1016/j.tibs.2013.06.011DOI Listing
September 2013

High-resolution analysis of cis-acting regulatory networks at the α-globin locus.

Philos Trans R Soc Lond B Biol Sci 2013 6;368(1620):20120361. Epub 2013 May 6.

MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, Oxford University, Oxford OX3 9DS, UK.

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http://dx.doi.org/10.1098/rstb.2012.0361DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3682726PMC
December 2013

Analysis of sequence variation underlying tissue-specific transcription factor binding and gene expression.

Hum Mutat 2013 Aug 18;34(8):1140-8. Epub 2013 Jun 18.

MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK.

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http://dx.doi.org/10.1002/humu.22343DOI Listing
August 2013

The molecular basis of α-thalassemia.

Authors:
Douglas R Higgs

Cold Spring Harb Perspect Med 2013 Jan 1;3(1):a011718. Epub 2013 Jan 1.

MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford OX3 9DS, UK.

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http://perspectivesinmedicine.cshlp.org/lookup/doi/10.1101/c
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http://dx.doi.org/10.1101/cshperspect.a011718DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3530043PMC
January 2013

Molecular biology: RNA discrimination.

Nature 2012 Feb 15;482(7385):310-1. Epub 2012 Feb 15.

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http://dx.doi.org/10.1038/482310aDOI Listing
February 2012

Thalassaemia.

Lancet 2012 Jan 9;379(9813):373-83. Epub 2011 Sep 9.

Medical Research Council Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK.

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http://dx.doi.org/10.1016/S0140-6736(11)60283-3DOI Listing
January 2012

Polycomb eviction as a new distant enhancer function.

Genes Dev 2011 Aug;25(15):1583-8

MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DS, UK.

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http://dx.doi.org/10.1101/gad.16985411DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3182025PMC
August 2011

Combinatorial readout of histone H3 modifications specifies localization of ATRX to heterochromatin.

Nat Struct Mol Biol 2011 Jun 12;18(7):777-82. Epub 2011 Jun 12.

Medical Research Council Laboratory of Molecular Biology, Cambridge, UK.

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http://dx.doi.org/10.1038/nsmb.2070DOI Listing
June 2011

Functional significance of mutations in the Snf2 domain of ATRX.

Hum Mol Genet 2011 Jul 19;20(13):2603-10. Epub 2011 Apr 19.

MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford, UK.

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http://dx.doi.org/10.1093/hmg/ddr163DOI Listing
July 2011

Global gene expression analysis of human erythroid progenitors.

Blood 2011 Mar 26;117(13):e96-108. Epub 2011 Jan 26.

Medical Research Council Molecular Hematology Unit, Weatherall Institute of Molecular Medicine, Oxford, UK.

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http://dx.doi.org/10.1182/blood-2010-07-290825DOI Listing
March 2011

ATRX: taming tandem repeats.

Cell Cycle 2010 Dec 1;9(23):4605-6. Epub 2010 Dec 1.

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http://dx.doi.org/10.4161/cc.9.23.14164DOI Listing
December 2010

The molecular basis of α-thalassemia: a model for understanding human molecular genetics.

Hematol Oncol Clin North Am 2010 Dec 29;24(6):1033-54. Epub 2010 Sep 29.

John Radcliffe Hospital, MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Headington, Oxford, UK.

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http://dx.doi.org/10.1016/j.hoc.2010.08.005DOI Listing
December 2010

Medicine. Sickle cell disease at 100 years.

Science 2010 Jul;329(5989):291-2

Children's Hospital Boston and Dana-Farber Cancer Institute, Harvard Medical School, Howard Hughes Medical Institute, Boston, MA 02115, USA.

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http://dx.doi.org/10.1126/science.1194035DOI Listing
July 2010

Alpha-thalassaemia.

Orphanet J Rare Dis 2010 May 28;5:13. Epub 2010 May 28.

1Department of Human and Clinical Genetics, Leiden University Medical Center, Einthovenweg 20, 2333ZC Leiden, The Netherlands.

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http://dx.doi.org/10.1186/1750-1172-5-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2887799PMC
May 2010

Adventitious changes in long-range gene expression caused by polymorphic structural variation and promoter competition.

Proc Natl Acad Sci U S A 2009 Dec 3;106(51):21771-6. Epub 2009 Dec 3.

Medical Research Council Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, The John Radcliffe Hospital, Headington, Oxford, OX3 9DS, United Kingdom.

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http://dx.doi.org/10.1073/pnas.0909331106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2799829PMC
December 2009

XNP/ATRX at sites of nucleosome replacement.

Epigenomics 2009 Dec;1(2):233-4

John Radcliffe Hospital, MRC Molecular Haematology Unit, The Weatherall Institute of Molecular Medicine, Headington, Oxford, UK.

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December 2009

The regulatory interplay of CpG islands and nucleosome remodeling at mammalian primary response genes.

Epigenomics 2009 Dec;1(2):233

John Radcliffe Hospital, MRC Molecular Haematology Unit, The Weatherall Institute of Molecular Medicine, Headington, Oxford, UK.

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December 2009

CTCF, cohesin and higher-order chromatin structure.

Epigenomics 2009 Dec;1(2):232

John Radcliffe Hospital, MRC Molecular Haematology Unit, The Weatherall Institute of Molecular Medicine, Headington, Oxford, UK.

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December 2009

Polycomb response elements in vertebrates.

Epigenomics 2009 Dec;1(2):231

John Radcliffe Hospital, MRC Molecular Haematology Unit, The Weatherall Institute of Molecular Medicine, Headington, Oxford, UK.

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http://dx.doi.org/10.2217/epi.09.36DOI Listing
December 2009

Chromosome looping at the human alpha-globin locus is mediated via the major upstream regulatory element (HS -40).

Blood 2009 Nov 20;114(19):4253-60. Epub 2009 Aug 20.

Medical Research Council (MRC) Molecular Haematology Unit, Weatherall Institute for Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DS United Kingdom.

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http://dx.doi.org/10.1182/blood-2009-03-213439DOI Listing
November 2009

Neuronal death resulting from targeted disruption of the Snf2 protein ATRX is mediated by p53.

J Neurosci 2008 Nov;28(47):12570-80

Department of Paediatrics, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada N6C 2V5.

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http://www.jneurosci.org/cgi/doi/10.1523/JNEUROSCI.4048-08.2
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http://dx.doi.org/10.1523/JNEUROSCI.4048-08.2008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6671724PMC
November 2008

Good news for the aging population?

Blood 2008 Oct;112(8):3001

Weatherall Institute of Molecular Medicine, USA.

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http://dx.doi.org/10.1182/blood-2008-08-171223DOI Listing
October 2008

Association between active genes occurs at nuclear speckles and is modulated by chromatin environment.

J Cell Biol 2008 Sep;182(6):1083-97

Medical Research Council Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, Oxford University, Oxford OX3 9DS, England, UK.

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http://dx.doi.org/10.1083/jcb.200803174DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2542471PMC
September 2008

Genetic complexity in sickle cell disease.

Proc Natl Acad Sci U S A 2008 Aug 11;105(33):11595-6. Epub 2008 Aug 11.

MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DS, United Kingdom.

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http://dx.doi.org/10.1073/pnas.0806633105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2575332PMC
August 2008

The role of the polycomb complex in silencing alpha-globin gene expression in nonerythroid cells.

Blood 2008 Nov 8;112(9):3889-99. Epub 2008 Aug 8.

Medical Research Council (MRC) Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, Oxford University, Oxford, UK.

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http://dx.doi.org/10.1182/blood-2008-06-161901DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2572806PMC
November 2008

A large deletion in the human alpha-globin cluster caused by a replication error is associated with an unexpectedly mild phenotype.

Hum Mol Genet 2008 Oct 15;17(19):3084-93. Epub 2008 Jul 15.

Medical Research Council Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford OX3 9DS, UK.

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http://dx.doi.org/10.1093/hmg/ddn205DOI Listing
October 2008

Switching genes on and off in haemopoiesis.

Biochem Soc Trans 2008 Aug;36(Pt 4):613-8

MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK.

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http://dx.doi.org/10.1042/BST0360613DOI Listing
August 2008

Long-range regulation of alpha globin gene expression during erythropoiesis.

Curr Opin Hematol 2008 May;15(3):176-83

MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford, UK.

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http://dx.doi.org/10.1097/MOH.0b013e3282f734c4DOI Listing
May 2008

A new dawn for stem-cell therapy.

Authors:
Douglas R Higgs

N Engl J Med 2008 Feb;358(9):964-6

Weatherall Institute of Molecular Medicine, Medical Research Council Molecular Haematology Unit, John Radcliffe Hospital, Oxford, United Kingdom.

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http://dx.doi.org/10.1056/NEJMcibr0708823DOI Listing
February 2008

Long-range regulation of alpha-globin gene expression.

Adv Genet 2008 ;61:143-73

MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DS, United Kingdom.

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http://dx.doi.org/10.1016/S0065-2660(07)00005-3DOI Listing
November 2008

Prevalence of erythrocyte haemoglobin H inclusions in unselected patients with clonal myeloid disorders.

Br J Haematol 2007 Nov;139(3):439-42

Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA.

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http://dx.doi.org/10.1111/j.1365-2141.2007.06831.xDOI Listing
November 2007

Tissue-specific histone modification and transcription factor binding in alpha globin gene expression.

Blood 2007 Dec 22;110(13):4503-10. Epub 2007 Aug 22.

Medical Research Council, Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, Oxford University, Oxford, UK.

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http://dx.doi.org/10.1182/blood-2007-06-097964DOI Listing
December 2007

Structural consequences of disease-causing mutations in the ATRX-DNMT3-DNMT3L (ADD) domain of the chromatin-associated protein ATRX.

Proc Natl Acad Sci U S A 2007 Jul 3;104(29):11939-44. Epub 2007 Jul 3.

Medical Research Council Molecular Haematology Unit, John Radcliffe Hospital, Oxford, United Kingdom.

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http://dx.doi.org/10.1073/pnas.0704057104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1924575PMC
July 2007

Using genomics to study how chromatin influences gene expression.

Annu Rev Genomics Hum Genet 2007 ;8:299-325

MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DS, United Kingdom.

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http://dx.doi.org/10.1146/annurev.genom.8.080706.092323DOI Listing
December 2007

Defining the cause of skewed X-chromosome inactivation in X-linked mental retardation by use of a mouse model.

Am J Hum Genet 2007 Jun 25;80(6):1138-49. Epub 2007 Apr 25.

MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK.

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http://dx.doi.org/10.1086/518369DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1867101PMC
June 2007

Long-range chromosomal interactions regulate the timing of the transition between poised and active gene expression.

EMBO J 2007 Apr 22;26(8):2041-51. Epub 2007 Mar 22.

MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford, UK.

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http://dx.doi.org/10.1038/sj.emboj.7601654DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1852780PMC
April 2007

Elderly survivors with homozygous sickle cell disease.

N Engl J Med 2007 Feb;356(6):642-3

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http://dx.doi.org/10.1056/NEJMc066547DOI Listing
February 2007

Manipulating the mouse genome to engineer precise functional syntenic replacements with human sequence.

Cell 2007 Jan;128(1):197-209

Institute for Stem Cell Research, University of Edinburgh, King's Buildings, West Mains Road, Edinburgh EH9 3JQ, United Kingdom.

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http://dx.doi.org/10.1016/j.cell.2006.11.044DOI Listing
January 2007

A regulatory SNP causes a human genetic disease by creating a new transcriptional promoter.

Science 2006 May;312(5777):1215-7

Medical Research Council Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, OX3 9DS, UK.

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http://dx.doi.org/10.1126/science.1126431DOI Listing
May 2006

Loss of Atrx affects trophoblast development and the pattern of X-inactivation in extraembryonic tissues.

PLoS Genet 2006 Apr 21;2(4):e58. Epub 2006 Apr 21.

MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom.

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http://dx.doi.org/10.1371/journal.pgen.0020058DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1440874PMC
April 2006