Publications

The Pseudokinase MLKL and the Kinase RIPK3 Have Distinct Roles in Autoimmune Disease Caused by Loss of Death-Receptor-Induced Apoptosis.
Immunity 2016 Sep 11;45(3):513-26. Epub 2016 Aug 11.
The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia; Department of Medical Biology, University of Melbourne, Parkville, Victoria 3050, Australia. Electronic address:


A Distinct Lung-Interstitium-Resident Memory CD8(+) T Cell Subset Confers Enhanced Protection to Lower Respiratory Tract Infection.
Cell Rep 2016 Aug 4;16(7):1800-9. Epub 2016 Aug 4.
Department of Veterans Affairs Tennessee Valley Healthcare System, Nashville, TN 37232, USA; Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA. Electronic address:







Proinflammatory signal suppresses proliferation and shifts macrophage metabolism from Myc-dependent to HIF1α-dependent.
Proc Natl Acad Sci U S A 2016 Feb 25;113(6):1564-9. Epub 2016 Jan 25.
Center for Childhood Cancer & Blood Diseases, The Research Institute at Nationwide Children's Hospital, Ohio State University, Columbus, OH 43205; Hematology/Oncology & Blood and Marrow Transplant, The Research Institute at Nationwide Children's Hospital, Ohio State University, Columbus, OH 43205;



Apoptosis-Inducing-Factor-Dependent Mitochondrial Function Is Required for T Cell but Not B Cell Function.
Immunity 2016 Jan 12;44(1):88-102. Epub 2016 Jan 12.
Department of Immunology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA. Electronic address:

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).
Autophagy 2016 ;12(1):1-222
kb Emory University, School of Medicine , Department of Microbiology and Immunology , Atlanta , GA , USA.

RIPK1 and NF-κB signaling in dying cells determines cross-priming of CD8⁺ T cells.
Science 2015 Oct 24;350(6258):328-34. Epub 2015 Sep 24.
Laboratory of Dendritic Cell Biology, Department of Immunology, Institut Pasteur, 25 Rue du Docteur Roux, 75015 Paris, France. Institut National de la Santé et de la Recherche Médicale, U818, 25 Rue du Docteur Roux, 75015 Paris, France.

Pin1-Induced Proline Isomerization in Cytosolic p53 Mediates BAX Activation and Apoptosis.
Mol Cell 2015 Aug 30;59(4):677-84. Epub 2015 Jul 30.
Department of Structural Biology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA; Department of Microbiology, Immunology and Biochemistry, University of Tennessee Health Sciences Center, 920 Court Avenue, Memphis, TN 38163, USA. Electronic address:

IL-21-mediated non-canonical pathway for IL-1β production in conventional dendritic cells.
Nat Commun 2015 Aug 13;6:7988. Epub 2015 Aug 13.
Laboratory of Molecular Immunology and the Immunology Center, National Heart, Lung and Blood Institute, National Institutes of Health, 10 Center Drive, Building 10, Room 7B05, Bethesda, Maryland 20892-1674 USA.


Caspase-8 scaffolding function and MLKL regulate NLRP3 inflammasome activation downstream of TLR3.
Nat Commun 2015 Jun 24;6:7515. Epub 2015 Jun 24.
Department of Biochemistry and Molecular Biology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.

Autophagy is essential for effector CD8(+) T cell survival and memory formation.
Nat Immunol 2014 Dec 2;15(12):1152-61. Epub 2014 Nov 2.
Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia, USA.

Viral suppressors of the RIG-I-mediated interferon response are pre-packaged in influenza virions.
Nat Commun 2014 Dec 9;5:5645. Epub 2014 Dec 9.
1] Institute of Molecular Virology (IMV), Center for Molecular Biology of Inflammation (ZMBE), University of Muenster, Von-Esmarch-Street 56, D-48149 Muenster, Germany [2] Cluster of Excellence Cells in Motion, University of Muenster, Muenster, Germany.

Myeloid-derived suppressor activity is mediated by monocytic lineages maintained by continuous inhibition of extrinsic and intrinsic death pathways.
Immunity 2014 Dec 11;41(6):947-59. Epub 2014 Dec 11.
Department of Infectious Diseases, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA; Department of Immunology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA. Electronic address:


Caspase-8 modulates dectin-1 and complement receptor 3-driven IL-1β production in response to β-glucans and the fungal pathogen, Candida albicans.
J Immunol 2014 Sep 25;193(5):2519-30. Epub 2014 Jul 25.
Program in Innate Immunity, Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605;

The DNA-binding domain mediates both nuclear and cytosolic functions of p53.
Nat Struct Mol Biol 2014 Jun 11;21(6):535-43. Epub 2014 May 11.
1] Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA. [2] Department of Microbiology, Immunology and Biochemistry, University of Tennessee Health Sciences Center, Memphis, Tennessee, USA.

Novel combination of mitochondrial division inhibitor 1 (mdivi-1) and platinum agents produces synergistic pro-apoptotic effect in drug resistant tumor cells.
Oncotarget 2014 Jun;5(12):4180-94
Department of Pharmacology and Chemical Biology, School of Medicine, University of Pittsburgh and Hillman Cancer Center, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213, USA.




Cutting edge: Endoplasmic reticulum stress licenses macrophages to produce mature IL-1β in response to TLR4 stimulation through a caspase-8- and TRIF-dependent pathway.
J Immunol 2014 Mar 31;192(5):2029-33. Epub 2014 Jan 31.
Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892;


Is SIRT2 required for necroptosis?
Nature 2014 Feb;506(7489):E4-6
1] The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia [2] Department of Medical Biology, University of Melbourne, Parkville, Victoria 3050, Australia.

Necroptosis.
N Engl J Med 2014 Jan;370(5):455-65
From the Division of Nephrology and Hypertension, Christian-Albrechts-University, Kiel, Germany (A.L.); and the Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN (D.R.G.).

Autosis is a Na+,K+-ATPase-regulated form of cell death triggered by autophagy-inducing peptides, starvation, and hypoxia-ischemia.
Proc Natl Acad Sci U S A 2013 Dec 25;110(51):20364-71. Epub 2013 Nov 25.
Center for Autophagy Research, Departments of Internal Medicine, Biochemistry, and Microbiology, and Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390.


Anthracyclines induce DNA damage response-mediated protection against severe sepsis.
Immunity 2013 Nov 31;39(5):874-84. Epub 2013 Oct 31.
Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, 1649-028 Lisboa, Portugal; Clínica Universitária de Cirurgia I, Centro Hospitalar Lisboa Norte, EPE, 1649-028 Lisboa, Portugal; Gulbenkian Programme for Advanced Medical Education, 2780-156 Oeiras, Portugal; Champalimaud Foundation, 1400-038 Lisboa, Portugal.

Widespread mitochondrial depletion via mitophagy does not compromise necroptosis.
Cell Rep 2013 Nov 21;5(4):878-85. Epub 2013 Nov 21.
Department of Immunology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA. Electronic address:

Two independent pathways of regulated necrosis mediate ischemia-reperfusion injury.
Proc Natl Acad Sci U S A 2013 Jul 1;110(29):12024-9. Epub 2013 Jul 1.
Division of Nephrology and Hypertension and Institute for Pathology, Christian-Albrechts-University, 24105 Kiel, Germany.





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