Douglas P Kiel

Douglas P Kiel

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Douglas P Kiel

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Validation of the FRAiL model to predict non-vertebral and hip fractures in nursing home residents.

Bone 2019 Nov 28;128:115050. Epub 2019 Aug 28.

Hebrew SeniorLife, Hinda and Arthur Marcus Institute for Aging Research, Boston, MA, United States of America; Beth Israel Deaconess Medical Center & Harvard Medical School, Boston, MA, United States of America.

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http://dx.doi.org/10.1016/j.bone.2019.115050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6823926PMC
November 2019

Corrigendum to "Incidence of hip fracture in native American residents of U.S. nursing homes" [Bone 123 (2019) 204-210].

Bone 2019 Oct 17;127:676. Epub 2019 Jul 17.

Department of Health Services, Policy and Practice, School of Public Health, Brown University, 121 South Main Street, Providence, RI 02912, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bone.2019.07.005DOI Listing
October 2019

Predictors of Hip Fracture Despite Treatment with Bisphosphonates among Frail Older Adults.

J Am Geriatr Soc 2019 Oct 3. Epub 2019 Oct 3.

Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Hinda and Arthur Marcus Institute for Aging Research, Hebrew SeniorLife, Boston, Massachusetts.

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http://dx.doi.org/10.1111/jgs.16176DOI Listing
October 2019

Antihypertensive Medication Use in Older Adults at Risk for Hip Fracture-Reply.

JAMA 2019 10;322(16):1609

Duke University School of Medicine, Durham, North Carolina.

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http://dx.doi.org/10.1001/jama.2019.13954DOI Listing
October 2019

The genetics of vitamin D.

Bone 2019 Sep 12;126:59-77. Epub 2018 Oct 12.

Program in Genetic Epidemiology, Harvard T.H. Chan School of Public Health, 677 Huntington Ave, Brookline, Boston 02115, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S87563282183037
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http://dx.doi.org/10.1016/j.bone.2018.10.006DOI Listing
September 2019

Preface to the BONE special issue on skeletal genomics.

Bone 2019 Sep 25;126. Epub 2019 May 25.

Department of Medicine Beth Israel Deaconess Medical Center and Harvard Medical School, Director Musculoskeletal Research Center, Hinda and Arthur Marcus Institute for Aging Research, Hebrew SeniorLife, Associate Member Broad Institute of Harvard and MIT, United States of America. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S87563282193021
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http://dx.doi.org/10.1016/j.bone.2019.05.030DOI Listing
September 2019

Post-Hip Fracture Mortality in Nursing Home Residents by Obesity Status.

J Am Geriatr Soc 2019 Sep 12;67(9):1983-1985. Epub 2019 Jun 12.

Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1111/jgs.16028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6732026PMC
September 2019

A Lot of Progress, With More to Be Done: A Response to NIH Pathways to Prevention Report "Research Gaps for Long-Term Drug Therapies for Osteoporotic Fracture Prevention".

J Bone Miner Res 2019 Sep 25;34(9):1549-1551. Epub 2019 Jul 25.

Harvard Medical School, Musculoskeletal Research Center, Marcus Institute for Aging Research, Hebrew SeniorLife, Boston, MA, USA.

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http://dx.doi.org/10.1002/jbmr.3823DOI Listing
September 2019

Body Composition and Genetic Lipodystrophy Risk Score Associate With Nonalcoholic Fatty Liver Disease and Liver Fibrosis.

Hepatol Commun 2019 Aug 18;3(8):1073-1084. Epub 2019 Jun 18.

Division of Gastroenterology and Hepatology, Department of Medicine University of Michigan Health System Ann Arbor MI.

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http://dx.doi.org/10.1002/hep4.1391DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6671828PMC
August 2019

A meta-analysis of genome-wide association studies identifies multiple longevity genes.

Nat Commun 2019 Aug 14;10(1):3669. Epub 2019 Aug 14.

NHLBI's and Boston University's Framingham Heart Study, Framingham, MA, 01702, USA.

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http://dx.doi.org/10.1038/s41467-019-11558-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6694136PMC
August 2019

Incidence of hip fracture in Native American residents of U.S. nursing homes.

Bone 2019 Jun 3;123:204-210. Epub 2019 Apr 3.

Department of Health Services, Policy and Practice, School of Public Health, Brown University, 121 South Main Street, Providence, RI 02912, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S87563282193012
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http://dx.doi.org/10.1016/j.bone.2019.04.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6527125PMC
June 2019

Hip Fractures in Older Adults in 2019.

JAMA 2019 06;321(22):2231-2232

Duke University School of Medicine, Durham, North Carolina.

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http://dx.doi.org/10.1001/jama.2019.5453DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6800121PMC
June 2019

Considering the Risks and Benefits of Osteoporosis Treatment in Older Adults.

JAMA Intern Med 2019 Jun 17. Epub 2019 Jun 17.

Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1001/jamainternmed.2019.0688DOI Listing
June 2019

Predictors of Imminent Risk of Nonvertebral Fracture in Older, High-Risk Women: The Framingham Osteoporosis Study.

JBMR Plus 2019 Jun 18;3(6):e10129. Epub 2019 Jan 18.

Institute for Aging Research Hebrew SeniorLife Department of Medicine Beth Israel Deaconess Medical Center, and Harvard Medical School Boston MA USA.

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http://dx.doi.org/10.1002/jbm4.10129DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6636767PMC
June 2019

Effect of Bisphosphonates on Fracture Outcomes Among Frail Older Adults.

J Am Geriatr Soc 2019 Apr 21;67(4):768-776. Epub 2018 Dec 21.

Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Marcus Institute for Aging Research, Hebrew SeniorLife, Boston, Massachusetts.

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http://dx.doi.org/10.1111/jgs.15725DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6705123PMC
April 2019

Genetics of Bone and Muscle Interactions in Humans.

Curr Osteoporos Rep 2019 Apr;17(2):86-95

Hebrew SeniorLife, Institute for Aging Research, Boston, MA, USA.

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http://dx.doi.org/10.1007/s11914-019-00505-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424938PMC
April 2019

Abdominal aortic calcification, bone mineral density and fractures: a systematic review and meta-analysis protocol.

BMJ Open 2019 Apr 2;9(4):e026232. Epub 2019 Apr 2.

The University of Sydney, Centre for Kidney Research, School of Public Health, Sydney Medical School, Children's Hospital at Westmead, New South Wales, Australia.

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http://dx.doi.org/10.1136/bmjopen-2018-026232DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6500258PMC
April 2019

Adding Lateral Spine Imaging for Vertebral Fractures to Densitometric Screening: Improving Ascertainment of Patients at High Risk of Incident Osteoporotic Fractures.

J Bone Miner Res 2019 Feb 5;34(2):282-289. Epub 2018 Nov 5.

Park Nicollet Osteoporosis Center and HealthPartners Institute, and Division of Health Policy and Management, University of Minnesota, Minneapolis, MN, USA.

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http://doi.wiley.com/10.1002/jbmr.3595
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http://dx.doi.org/10.1002/jbmr.3595DOI Listing
February 2019

Disentangling the genetics of lean mass.

Authors:
David Karasik M Carola Zillikens Yi-Hsiang Hsu Ali Aghdassi Kristina Akesson Najaf Amin Inês Barroso David A Bennett Lars Bertram Murielle Bochud Ingrid B Borecki Linda Broer Aron S Buchman Liisa Byberg Harry Campbell Natalia Campos-Obando Jane A Cauley Peggy M Cawthon John C Chambers Zhao Chen Nam H Cho Hyung Jin Choi Wen-Chi Chou Steven R Cummings Lisette C P G M de Groot Phillip L De Jager Ilja Demuth Luda Diatchenko Michael J Econs Gudny Eiriksdottir Anke W Enneman Joel Eriksson Johan G Eriksson Karol Estrada Daniel S Evans Mary F Feitosa Mao Fu Christian Gieger Harald Grallert Vilmundur Gudnason Launer J Lenore Caroline Hayward Albert Hofman Georg Homuth Kim M Huffman Lise B Husted Thomas Illig Erik Ingelsson Till Ittermann John-Olov Jansson Toby Johnson Reiner Biffar Joanne M Jordan Antti Jula Magnus Karlsson Kay-Tee Khaw Tuomas O Kilpeläinen Norman Klopp Jacqueline S L Kloth Daniel L Koller Jaspal S Kooner William E Kraus Stephen Kritchevsky Zoltán Kutalik Teemu Kuulasmaa Johanna Kuusisto Markku Laakso Jari Lahti Thomas Lang Bente L Langdahl Markus M Lerch Joshua R Lewis Christina Lill Lars Lind Cecilia Lindgren Yongmei Liu Gregory Livshits Östen Ljunggren Ruth J F Loos Mattias Lorentzon Jian'an Luan Robert N Luben Ida Malkin Fiona E McGuigan Carolina Medina-Gomez Thomas Meitinger Håkan Melhus Dan Mellström Karl Michaëlsson Braxton D Mitchell Andrew P Morris Leif Mosekilde Maria Nethander Anne B Newman Jeffery R O'Connell Ben A Oostra Eric S Orwoll Aarno Palotie Munro Peacock Markus Perola Annette Peters Richard L Prince Bruce M Psaty Katri Räikkönen Stuart H Ralston Samuli Ripatti Fernando Rivadeneira John A Robbins Jerome I Rotter Igor Rudan Veikko Salomaa Suzanne Satterfield Sabine Schipf Chan Soo Shin Albert V Smith Shad B Smith Nicole Soranzo Timothy D Spector Alena Stancáková Kari Stefansson Elisabeth Steinhagen-Thiessen Lisette Stolk Elizabeth A Streeten Unnur Styrkarsdottir Karin M A Swart Patricia Thompson Cynthia A Thomson Gudmar Thorleifsson Unnur Thorsteinsdottir Emmi Tikkanen Gregory J Tranah André G Uitterlinden Cornelia M van Duijn Natasja M van Schoor Liesbeth Vandenput Peter Vollenweider Henry Völzke Jean Wactawski-Wende Mark Walker Nicholas J Wareham Dawn Waterworth Michael N Weedon H-Erich Wichmann Elisabeth Widen Frances M K Williams James F Wilson Nicole C Wright Laura M Yerges-Armstrong Lei Yu Weihua Zhang Jing Hua Zhao Yanhua Zhou Carrie M Nielson Tamara B Harris Serkalem Demissie Douglas P Kiel Claes Ohlsson

Am J Clin Nutr 2019 02;109(2):276-287

Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

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http://dx.doi.org/10.1093/ajcn/nqy272DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6500901PMC
February 2019

Aortic Calcification is Associated with Five-Year Decline in Handgrip Strength in Older Women.

Calcif Tissue Int 2018 12 23;103(6):589-598. Epub 2018 Jul 23.

Sir Charles Gairdner Hospital Unit, Medical School, University of Western Australia, Nedlands, WA, Australia.

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http://link.springer.com/10.1007/s00223-018-0458-5
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http://dx.doi.org/10.1007/s00223-018-0458-5DOI Listing
December 2018

A longitudinal study of disc height narrowing and facet joint osteoarthritis at the thoracic and lumbar spine, evaluated by computed tomography: the Framingham Study.

Spine J 2018 11 19;18(11):2065-2073. Epub 2018 Apr 19.

Institute for Aging Research, Hebrew SeniorLife, 1200 Center St, Boston, MA 02131, USA; Department of Medicine, Harvard Medical School, 25 Shattuck St, Boston, MA, 02115, USA; Division of Gerontology, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA, 02215, USA. Electronic address:

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http://dx.doi.org/10.1016/j.spinee.2018.04.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6195485PMC
November 2018

Epidemiology of hip fracture in nursing home residents with multiple sclerosis.

Disabil Health J 2018 10 21;11(4):591-597. Epub 2018 Mar 21.

Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States; Hebrew SeniorLife, Institute for Aging Research, Boston, Massachusetts, United States. Electronic address:

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http://dx.doi.org/10.1016/j.dhjo.2018.03.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6150858PMC
October 2018

Harmonizing finite element modelling for non-invasive strength estimation by high-resolution peripheral quantitative computed tomography.

J Biomech 2018 10 29;80:63-71. Epub 2018 Aug 29.

McCaig Institute for Bone and Joint Health and Department of Radiology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jbiomech.2018.08.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6188787PMC
October 2018

Association of Alendronate and Risk of Cardiovascular Events in Patients With Hip Fracture.

J Bone Miner Res 2018 08 9;33(8):1422-1434. Epub 2018 May 9.

Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong.

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http://dx.doi.org/10.1002/jbmr.3448DOI Listing
August 2018

Higher Dairy Food Intake Is Associated With Higher Spine Quantitative Computed Tomography (QCT) Bone Measures in the Framingham Study for Men But Not Women.

J Bone Miner Res 2018 07 30;33(7):1283-1290. Epub 2018 Mar 30.

Institute for Aging Research, Hebrew SeniorLife, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1002/jbmr.3414DOI Listing
July 2018

Association of Clinical Outcomes With Surgical Repair of Hip Fracture vs Nonsurgical Management in Nursing Home Residents With Advanced Dementia.

JAMA Intern Med 2018 06;178(6):774-780

Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1001/jamainternmed.2018.0743DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5997966PMC
June 2018

Fracture Risk Assessment in Long-term Care (FRAiL): Development and Validation of a Prediction Model.

J Gerontol A Biol Sci Med Sci 2018 05;73(6):763-769

Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1093/gerona/glx147DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5946931PMC
May 2018

Identification of a novel locus on chromosome 2q13, which predisposes to clinical vertebral fractures independently of bone density.

Ann Rheum Dis 2018 03 23;77(3):378-385. Epub 2017 Nov 23.

Rheumatology and Bone Disease Unit, Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.

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http://dx.doi.org/10.1136/annrheumdis-2017-212469DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5912156PMC
March 2018

Facility and State Variation in Hip Fracture in U.S. Nursing Home Residents.

J Am Geriatr Soc 2018 03 16;66(3):539-545. Epub 2018 Jan 16.

Department of Medicine, Hebrew SeniorLife, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1111/jgs.15264DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5849498PMC
March 2018

Association Between Dietary Fiber Intake and Bone Loss in the Framingham Offspring Study.

J Bone Miner Res 2018 02 7;33(2):241-249. Epub 2017 Nov 7.

Institute for Aging Research, Hebrew SeniorLife, and Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1002/jbmr.3308DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5990003PMC
February 2018

Pain Treatments After Hip Fracture Among Older Nursing Home Residents.

J Am Med Dir Assoc 2018 02 26;19(2):174-176. Epub 2017 Dec 26.

Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Institute for Aging Research, Hebrew SeniorLife, Boston, MA.

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http://dx.doi.org/10.1016/j.jamda.2017.11.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5803325PMC
February 2018

Life-Course Genome-wide Association Study Meta-analysis of Total Body BMD and Assessment of Age-Specific Effects.

Am J Hum Genet 2018 01;102(1):88-102

Department of Internal Medicine, Erasmus MC, 3000 CA Rotterdam, the Netherlands; The Generation R Study Group, Erasmus MC, 3000 CA Rotterdam, the Netherlands; Department of Epidemiology, Erasmus MC, 3000 CA Rotterdam, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2017.12.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5777980PMC
January 2018

Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels.

Authors:
Xia Jiang Paul F O'Reilly Hugues Aschard Yi-Hsiang Hsu J Brent Richards Josée Dupuis Erik Ingelsson David Karasik Stefan Pilz Diane Berry Bryan Kestenbaum Jusheng Zheng Jianan Luan Eleni Sofianopoulou Elizabeth A Streeten Demetrius Albanes Pamela L Lutsey Lu Yao Weihong Tang Michael J Econs Henri Wallaschofski Henry Völzke Ang Zhou Chris Power Mark I McCarthy Erin D Michos Eric Boerwinkle Stephanie J Weinstein Neal D Freedman Wen-Yi Huang Natasja M Van Schoor Nathalie van der Velde Lisette C P G M de Groot Anke Enneman L Adrienne Cupples Sarah L Booth Ramachandran S Vasan Ching-Ti Liu Yanhua Zhou Samuli Ripatti Claes Ohlsson Liesbeth Vandenput Mattias Lorentzon Johan G Eriksson M Kyla Shea Denise K Houston Stephen B Kritchevsky Yongmei Liu Kurt K Lohman Luigi Ferrucci Munro Peacock Christian Gieger Marian Beekman Eline Slagboom Joris Deelen Diana van Heemst Marcus E Kleber Winfried März Ian H de Boer Alexis C Wood Jerome I Rotter Stephen S Rich Cassianne Robinson-Cohen Martin den Heijer Marjo-Riitta Jarvelin Alana Cavadino Peter K Joshi James F Wilson Caroline Hayward Lars Lind Karl Michaëlsson Stella Trompet M Carola Zillikens Andre G Uitterlinden Fernando Rivadeneira Linda Broer Lina Zgaga Harry Campbell Evropi Theodoratou Susan M Farrington Maria Timofeeva Malcolm G Dunlop Ana M Valdes Emmi Tikkanen Terho Lehtimäki Leo-Pekka Lyytikäinen Mika Kähönen Olli T Raitakari Vera Mikkilä M Arfan Ikram Naveed Sattar J Wouter Jukema Nicholas J Wareham Claudia Langenberg Nita G Forouhi Thomas E Gundersen Kay-Tee Khaw Adam S Butterworth John Danesh Timothy Spector Thomas J Wang Elina Hyppönen Peter Kraft Douglas P Kiel

Nat Commun 2018 01 17;9(1):260. Epub 2018 Jan 17.

Institute for Aging Research, Hebrew SeniorLife, 1200 Centre Street, Boston, MA, 02131, USA.

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http://dx.doi.org/10.1038/s41467-017-02662-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5772647PMC
January 2018

Abdominal aortic calcification on dual-energy X-ray absorptiometry: Methods of assessment and clinical significance.

Bone 2017 Nov 22;104:91-100. Epub 2017 Jan 22.

Institute for Aging Research, Hebrew Senior Life, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1016/j.bone.2017.01.025DOI Listing
November 2017

Erratum: Large meta-analysis of genome-wide association studies identifies five loci for lean body mass.

Authors:
M Carola Zillikens Serkalem Demissie Yi-Hsiang Hsu Laura M Yerges-Armstrong Wen-Chi Chou Lisette Stolk Gregory Livshits Linda Broer Toby Johnson Daniel L Koller Zoltán Kutalik Jian'an Luan Ida Malkin Janina S Ried Albert V Smith Gudmar Thorleifsson Liesbeth Vandenput Jing Hua Zhao Weihua Zhang Ali Aghdassi Kristina Åkesson Najaf Amin Leslie J Baier Inês Barroso David A Bennett Lars Bertram Rainer Biffar Murielle Bochud Michael Boehnke Ingrid B Borecki Aron S Buchman Liisa Byberg Harry Campbell Natalia Campos Obanda Jane A Cauley Peggy M Cawthon Henna Cederberg Zhao Chen Nam H Cho Hyung Jin Choi Melina Claussnitzer Francis Collins Steven R Cummings Philip L De Jager Ilja Demuth Rosalie A M Dhonukshe-Rutten Luda Diatchenko Gudny Eiriksdottir Anke W Enneman Mike Erdos Johan G Eriksson Joel Eriksson Karol Estrada Daniel S Evans Mary F Feitosa Mao Fu Melissa Garcia Christian Gieger Thomas Girke Nicole L Glazer Harald Grallert Jagvir Grewal Bok-Ghee Han Robert L Hanson Caroline Hayward Albert Hofman Eric P Hoffman Georg Homuth Wen-Chi Hsueh Monica J Hubal Alan Hubbard Kim M Huffman Lise B Husted Thomas Illig Erik Ingelsson Till Ittermann John-Olov Jansson Joanne M Jordan Antti Jula Magnus Karlsson Kay-Tee Khaw Tuomas O Kilpeläinen Norman Klopp Jacqueline S L Kloth Heikki A Koistinen William E Kraus Stephen Kritchevsky Teemu Kuulasmaa Johanna Kuusisto Markku Laakso Jari Lahti Thomas Lang Bente L Langdahl Lenore J Launer Jong-Young Lee Markus M Lerch Joshua R Lewis Lars Lind Cecilia Lindgren Yongmei Liu Tian Liu Youfang Liu Östen Ljunggren Mattias Lorentzon Robert N Luben William Maixner Fiona E McGuigan Carolina Medina-Gomez Thomas Meitinger Håkan Melhus Dan Mellström Simon Melov Karl Michaëlsson Braxton D Mitchell Andrew P Morris Leif Mosekilde Anne Newman Carrie M Nielson Jeffrey R O'Connell Ben A Oostra Eric S Orwoll Aarno Palotie Stephen C J Parker Munro Peacock Markus Perola Annette Peters Ozren Polasek Richard L Prince Katri Räikkönen Stuart H Ralston Samuli Ripatti John A Robbins Jerome I Rotter Igor Rudan Veikko Salomaa Suzanne Satterfield Eric E Schadt Sabine Schipf Laura Scott Joban Sehmi Jian Shen Chan Soo Shin Gunnar Sigurdsson Shad Smith Nicole Soranzo Alena Stančáková Elisabeth Steinhagen-Thiessen Elizabeth A Streeten Unnur Styrkarsdottir Karin M A Swart Sian-Tsung Tan Mark A Tarnopolsky Patricia Thompson Cynthia A Thomson Unnur Thorsteinsdottir Emmi Tikkanen Gregory J Tranah Jaakko Tuomilehto Natasja M van Schoor Arjun Verma Peter Vollenweider Henry Völzke Jean Wactawski-Wende Mark Walker Michael N Weedon Ryan Welch H-Erich Wichmann Elisabeth Widen Frances M K Williams James F Wilson Nicole C Wright Weijia Xie Lei Yu Yanhua Zhou John C Chambers Angela Döring Cornelia M van Duijn Michael J Econs Vilmundur Gudnason Jaspal S Kooner Bruce M Psaty Timothy D Spector Kari Stefansson Fernando Rivadeneira André G Uitterlinden Nicholas J Wareham Vicky Ossowski Dawn Waterworth Ruth J F Loos David Karasik Tamara B Harris Claes Ohlsson Douglas P Kiel

Nat Commun 2017 11 7;8(1):1414. Epub 2017 Nov 7.

Hebrew SeniorLife, Institute for Aging Research, Roslindale, MA, 02131, USA.

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http://dx.doi.org/10.1038/s41467-017-01008-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5676783PMC
November 2017

Low-Frequency Synonymous Coding Variation in CYP2R1 Has Large Effects on Vitamin D Levels and Risk of Multiple Sclerosis.

Am J Hum Genet 2017 Aug 27;101(2):227-238. Epub 2017 Jul 27.

Department of Human Genetics, McGill University, Montreal, QC H3A 1B1, Canada; Lady Davis Institute for Medical Research, Jewish General Hospital, McGill University, Montreal, QC H3T 1E2, Canada; Department of Twin Research and Genetic Epidemiology, King's College London, London WC2R 2LS, UK; Department of Medicine, McGill University, Montreal, QC H3G 1Y6, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2017.06.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5544392PMC
August 2017

Reply to G Bahat and MA Karan.

Am J Clin Nutr 2017 08;106(2):703

From the Department of Biomedical and Nutritional Sciences, University of Massachusetts, Lowell, MA (KLT; KMM, e-mail: and the Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA (SS, DPK, ABD, and MTH).

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http://dx.doi.org/10.3945/ajcn.117.160150DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5525127PMC
August 2017

Large meta-analysis of genome-wide association studies identifies five loci for lean body mass.

Authors:
M Carola Zillikens Serkalem Demissie Yi-Hsiang Hsu Laura M Yerges-Armstrong Wen-Chi Chou Lisette Stolk Gregory Livshits Linda Broer Toby Johnson Daniel L Koller Zoltán Kutalik Jian'an Luan Ida Malkin Janina S Ried Albert V Smith Gudmar Thorleifsson Liesbeth Vandenput Jing Hua Zhao Weihua Zhang Ali Aghdassi Kristina Åkesson Najaf Amin Leslie J Baier Inês Barroso David A Bennett Lars Bertram Rainer Biffar Murielle Bochud Michael Boehnke Ingrid B Borecki Aron S Buchman Liisa Byberg Harry Campbell Natalia Campos Obanda Jane A Cauley Peggy M Cawthon Henna Cederberg Zhao Chen Nam H Cho Hyung Jin Choi Melina Claussnitzer Francis Collins Steven R Cummings Philip L De Jager Ilja Demuth Rosalie A M Dhonukshe-Rutten Luda Diatchenko Gudny Eiriksdottir Anke W Enneman Mike Erdos Johan G Eriksson Joel Eriksson Karol Estrada Daniel S Evans Mary F Feitosa Mao Fu Melissa Garcia Christian Gieger Thomas Girke Nicole L Glazer Harald Grallert Jagvir Grewal Bok-Ghee Han Robert L Hanson Caroline Hayward Albert Hofman Eric P Hoffman Georg Homuth Wen-Chi Hsueh Monica J Hubal Alan Hubbard Kim M Huffman Lise B Husted Thomas Illig Erik Ingelsson Till Ittermann John-Olov Jansson Joanne M Jordan Antti Jula Magnus Karlsson Kay-Tee Khaw Tuomas O Kilpeläinen Norman Klopp Jacqueline S L Kloth Heikki A Koistinen William E Kraus Stephen Kritchevsky Teemu Kuulasmaa Johanna Kuusisto Markku Laakso Jari Lahti Thomas Lang Bente L Langdahl Lenore J Launer Jong-Young Lee Markus M Lerch Joshua R Lewis Lars Lind Cecilia Lindgren Yongmei Liu Tian Liu Youfang Liu Östen Ljunggren Mattias Lorentzon Robert N Luben William Maixner Fiona E McGuigan Carolina Medina-Gomez Thomas Meitinger Håkan Melhus Dan Mellström Simon Melov Karl Michaëlsson Braxton D Mitchell Andrew P Morris Leif Mosekilde Anne Newman Carrie M Nielson Jeffrey R O'Connell Ben A Oostra Eric S Orwoll Aarno Palotie Stephen C J Parker Munro Peacock Markus Perola Annette Peters Ozren Polasek Richard L Prince Katri Räikkönen Stuart H Ralston Samuli Ripatti John A Robbins Jerome I Rotter Igor Rudan Veikko Salomaa Suzanne Satterfield Eric E Schadt Sabine Schipf Laura Scott Joban Sehmi Jian Shen Chan Soo Shin Gunnar Sigurdsson Shad Smith Nicole Soranzo Alena Stančáková Elisabeth Steinhagen-Thiessen Elizabeth A Streeten Unnur Styrkarsdottir Karin M A Swart Sian-Tsung Tan Mark A Tarnopolsky Patricia Thompson Cynthia A Thomson Unnur Thorsteinsdottir Emmi Tikkanen Gregory J Tranah Jaakko Tuomilehto Natasja M van Schoor Arjun Verma Peter Vollenweider Henry Völzke Jean Wactawski-Wende Mark Walker Michael N Weedon Ryan Welch H-Erich Wichmann Elisabeth Widen Frances M K Williams James F Wilson Nicole C Wright Weijia Xie Lei Yu Yanhua Zhou John C Chambers Angela Döring Cornelia M van Duijn Michael J Econs Vilmundur Gudnason Jaspal S Kooner Bruce M Psaty Timothy D Spector Kari Stefansson Fernando Rivadeneira André G Uitterlinden Nicholas J Wareham Vicky Ossowski Dawn Waterworth Ruth J F Loos David Karasik Tamara B Harris Claes Ohlsson Douglas P Kiel

Nat Commun 2017 07 19;8(1):80. Epub 2017 Jul 19.

Hebrew SeniorLife, Institute for Aging Research, Roslindale, MA, 02131, USA.

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http://dx.doi.org/10.1038/s41467-017-00031-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5517526PMC
July 2017

Large-scale GWAS identifies multiple loci for hand grip strength providing biological insights into muscular fitness.

Nat Commun 2017 07 12;8:16015. Epub 2017 Jul 12.

MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge CB2 0QQ, UK.

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http://dx.doi.org/10.1038/ncomms16015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5510175PMC
July 2017

Addressing the Crisis in the Treatment of Osteoporosis: A Path Forward.

J Bone Miner Res 2017 03 29;32(3):424-430. Epub 2016 Dec 29.

Division of Endocrinology, Department of Medicine, Columbia University, New York, NY, USA.

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http://dx.doi.org/10.1002/jbmr.3074DOI Listing
March 2017

Vitamin D, bones and muscle: myth versus reality.

Australas J Ageing 2017 Mar;36 Suppl 1:8-13

Institute for Aging Research, Hebrew SeniorLife, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1111/ajag.12408DOI Listing
March 2017

Intermittent Nitrate Use and Risk of Hip Fracture.

Am J Med 2017 02 6;130(2):229.e15-229.e20. Epub 2016 Oct 6.

Boston University School of Medicine, Mass.

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http://dx.doi.org/10.1016/j.amjmed.2016.09.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5262534PMC
February 2017

Heritability and Genetic Correlations for Bone Microarchitecture: The Framingham Study Families.

J Bone Miner Res 2017 01 26;32(1):106-114. Epub 2016 Oct 26.

Institute for Aging Research, Hebrew SeniorLife, Boston, MA, USA.

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http://dx.doi.org/10.1002/jbmr.2915DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5310688PMC
January 2017

A combined reference panel from the 1000 Genomes and UK10K projects improved rare variant imputation in European and Chinese samples.

Sci Rep 2016 12 22;6:39313. Epub 2016 Dec 22.

Institute for Aging Research, Hebrew SeniorLife, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1038/srep39313DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5177868PMC
December 2016

Medication Review After a Fracture-Absolutely Essential.

JAMA Intern Med 2016 10;176(10):1539-1540

Department of Medicine, Beth Israel Deaconess Medical Center & Harvard Medical School, Boston Massachusetts2Hebrew SeniorLife, Institute for Aging Research, Boston, Massachusetts.

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http://dx.doi.org/10.1001/jamainternmed.2016.4822DOI Listing
October 2016

Epigenetic Signatures of Cigarette Smoking.

Circ Cardiovasc Genet 2016 Oct 20;9(5):436-447. Epub 2016 Sep 20.

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http://dx.doi.org/10.1161/CIRCGENETICS.116.001506DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5267325PMC
October 2016

Associations of Computed Tomography-Based Trunk Muscle Size and Density With Balance and Falls in Older Adults.

J Gerontol A Biol Sci Med Sci 2016 06 26;71(6):811-6. Epub 2015 Oct 26.

Institute for Aging Research, Hebrew SeniorLife, Boston, Massachusetts. Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1093/gerona/glv185DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4888389PMC
June 2016

Dietary Protein Intake Is Protective Against Loss of Grip Strength Among Older Adults in the Framingham Offspring Cohort.

J Gerontol A Biol Sci Med Sci 2016 Mar 2;71(3):356-61. Epub 2015 Nov 2.

Institute for Aging Research, Hebrew SeniorLife, Boston, Massachusetts. Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1093/gerona/glv184DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5864162PMC
March 2016

Antipsychotic and Benzodiazepine Drug Changes Affect Acute Falls Risk Differently in the Nursing Home.

J Gerontol A Biol Sci Med Sci 2016 Feb 5;71(2):273-8. Epub 2015 Aug 5.

Division of Gerontology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts. Institute for Aging Research, Hebrew SeniorLife, Boston, Massachusetts.

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http://dx.doi.org/10.1093/gerona/glv091DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4881828PMC
February 2016

Vitamin D Supplementation and Increased Risk of Falling: A Cautionary Tale of Vitamin Supplements Retold.

JAMA Intern Med 2016 Feb;176(2):171-2

Department of Epidemiology and Biostatistics, University of California San Francisco.

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http://dx.doi.org/10.1001/jamainternmed.2015.7568DOI Listing
February 2016

New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk.

Authors:
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Nat Commun 2016 Feb 1;7:10495. Epub 2016 Feb 1.

The Charles Bronfman Institute for Personalized Medicine, The Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.

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http://dx.doi.org/10.1038/ncomms10495DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4740398PMC
February 2016

Abdominal Aortic Calcification Identified on Lateral Spine Images From Bone Densitometers Are a Marker of Generalized Atherosclerosis in Elderly Women.

Arterioscler Thromb Vasc Biol 2016 Jan 24;36(1):166-173. Epub 2015 Nov 24.

University of Western Australia School of Medicine and Pharmacology, Sir Charles Gairdner Hospital Unit, Perth, Australia.

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http://dx.doi.org/10.1161/ATVBAHA.115.306383DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4702255PMC
January 2016

Abdominal aortic calcification and risk of fracture among older women - The SOF study.

Bone 2015 Dec 24;81:16-23. Epub 2015 Jun 24.

Department of Medicine and Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN, USA; Center for Chronic Disease Outcomes Research, VA Health Care System, Minneapolis, MN, USA.

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http://dx.doi.org/10.1016/j.bone.2015.06.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4640997PMC
December 2015

Whole-genome sequencing identifies EN1 as a determinant of bone density and fracture.

Authors:
Hou-Feng Zheng Vincenzo Forgetta Yi-Hsiang Hsu Karol Estrada Alberto Rosello-Diez Paul J Leo Chitra L Dahia Kyung Hyun Park-Min Jonathan H Tobias Charles Kooperberg Aaron Kleinman Unnur Styrkarsdottir Ching-Ti Liu Charlotta Uggla Daniel S Evans Carrie M Nielson Klaudia Walter Ulrika Pettersson-Kymmer Shane McCarthy Joel Eriksson Tony Kwan Mila Jhamai Katerina Trajanoska Yasin Memari Josine Min Jie Huang Petr Danecek Beth Wilmot Rui Li Wen-Chi Chou Lauren E Mokry Alireza Moayyeri Melina Claussnitzer Chia-Ho Cheng Warren Cheung Carolina Medina-Gómez Bing Ge Shu-Huang Chen Kwangbom Choi Ling Oei James Fraser Robert Kraaij Matthew A Hibbs Celia L Gregson Denis Paquette Albert Hofman Carl Wibom Gregory J Tranah Mhairi Marshall Brooke B Gardiner Katie Cremin Paul Auer Li Hsu Sue Ring Joyce Y Tung Gudmar Thorleifsson Anke W Enneman Natasja M van Schoor Lisette C P G M de Groot Nathalie van der Velde Beatrice Melin John P Kemp Claus Christiansen Adrian Sayers Yanhua Zhou Sophie Calderari Jeroen van Rooij Chris Carlson Ulrike Peters Soizik Berlivet Josée Dostie Andre G Uitterlinden Stephen R Williams Charles Farber Daniel Grinberg Andrea Z LaCroix Jeff Haessler Daniel I Chasman Franco Giulianini Lynda M Rose Paul M Ridker John A Eisman Tuan V Nguyen Jacqueline R Center Xavier Nogues Natalia Garcia-Giralt Lenore L Launer Vilmunder Gudnason Dan Mellström Liesbeth Vandenput Najaf Amin Cornelia M van Duijn Magnus K Karlsson Östen Ljunggren Olle Svensson Göran Hallmans François Rousseau Sylvie Giroux Johanne Bussière Pascal P Arp Fjorda Koromani Richard L Prince Joshua R Lewis Bente L Langdahl A Pernille Hermann Jens-Erik B Jensen Stephen Kaptoge Kay-Tee Khaw Jonathan Reeve Melissa M Formosa Angela Xuereb-Anastasi Kristina Åkesson Fiona E McGuigan Gaurav Garg Jose M Olmos Maria T Zarrabeitia Jose A Riancho Stuart H Ralston Nerea Alonso Xi Jiang David Goltzman Tomi Pastinen Elin Grundberg Dominique Gauguier Eric S Orwoll David Karasik George Davey-Smith Albert V Smith Kristin Siggeirsdottir Tamara B Harris M Carola Zillikens Joyce B J van Meurs Unnur Thorsteinsdottir Matthew T Maurano Nicholas J Timpson Nicole Soranzo Richard Durbin Scott G Wilson Evangelia E Ntzani Matthew A Brown Kari Stefansson David A Hinds Tim Spector L Adrienne Cupples Claes Ohlsson Celia M T Greenwood Rebecca D Jackson David W Rowe Cynthia A Loomis David M Evans Cheryl L Ackert-Bicknell Alexandra L Joyner Emma L Duncan Douglas P Kiel Fernando Rivadeneira J Brent Richards

Nature 2015 Oct 14;526(7571):112-7. Epub 2015 Sep 14.

Departments of Medicine, Human Genetics, Epidemiology and Biostatistics, McGill University, Montréal H3A 1A2, Canada.

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http://dx.doi.org/10.1038/nature14878DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4755714PMC
October 2015

Dietary Approaches for Bone Health: Lessons from the Framingham Osteoporosis Study.

Curr Osteoporos Rep 2015 Aug;13(4):245-55

Institute for Aging Research, Hebrew SeniorLife, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 1200 Centre St., Boston, MA, 02131, USA,

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http://dx.doi.org/10.1007/s11914-015-0272-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4928581PMC
August 2015