Douglas Melton

Douglas Melton

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Douglas Melton

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Synchronized stimulation and continuous insulin sensing in a microfluidic human Islet on a Chip designed for scalable manufacturing.

Lab Chip 2019 Sep;19(18):2993-3010

Disease Biophysics Group, Wyss Institute for Biologically Inspired Engineering, Harvard John A. Paulson School of Engineering and Applied Sciences, Harvard University, Pierce Hall, 29 Oxford Street, Cambridge, MA 02138, USA.

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http://dx.doi.org/10.1039/c9lc00253gDOI Listing
September 2019

Generation of hypoimmunogenic human pluripotent stem cells.

Proc Natl Acad Sci U S A 2019 May 30;116(21):10441-10446. Epub 2019 Apr 30.

Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138;

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http://dx.doi.org/10.1073/pnas.1902566116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6535035PMC
May 2019

Charting cellular identity during human in vitro β-cell differentiation.

Nature 2019 May 8;569(7756):368-373. Epub 2019 May 8.

Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.

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http://dx.doi.org/10.1038/s41586-019-1168-5DOI Listing
May 2019

Wnt Signaling Separates the Progenitor and Endocrine Compartments during Pancreas Development.

Cell Rep 2019 May;27(8):2281-2291.e5

Department of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22111247193056
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http://dx.doi.org/10.1016/j.celrep.2019.04.083DOI Listing
May 2019

YAP inhibition enhances the differentiation of functional stem cell-derived insulin-producing β cells.

Nat Commun 2019 04 1;10(1):1464. Epub 2019 Apr 1.

Department of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Harvard University, Cambridge, MA, 02138, USA.

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http://dx.doi.org/10.1038/s41467-019-09404-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443737PMC
April 2019

Regenerating the field of cardiovascular cell therapy.

Nat Biotechnol 2019 03 18;37(3):232-237. Epub 2019 Feb 18.

Institute for Stem Cell Biology and Regenerative Medicine; Ludwig Center for Cancer Stem Cell Biology and Medicine; Departments of Pathology and Developmental Biology, Stanford University School of Medicine, Stanford, CA, USA.

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http://www.nature.com/articles/s41587-019-0042-1
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http://dx.doi.org/10.1038/s41587-019-0042-1DOI Listing
March 2019

Blastemal progenitors modulate immune signaling during early limb regeneration.

Development 2019 01 2;146(1). Epub 2019 Jan 2.

Department of Stem Cell and Regenerative Biology, Harvard University, 7 Divinity Avenue, Cambridge, MA 02138, USA

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http://dev.biologists.org/lookup/doi/10.1242/dev.169128
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http://dx.doi.org/10.1242/dev.169128DOI Listing
January 2019

New Approaches, New Opportunities at the 2019 ISSCR Annual Meeting.

Stem Cell Reports 2018 12;11(6):1305

2019 ISSCR Program Committee Chair.

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http://dx.doi.org/10.1016/j.stemcr.2018.11.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294715PMC
December 2018

Author Correction: Pancreas regeneration.

Nature 2018 08;560(7720):E34

Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.

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http://dx.doi.org/10.1038/s41586-018-0294-9DOI Listing
August 2018

Pancreas regeneration.

Nature 2018 05 16;557(7705):351-358. Epub 2018 May 16.

Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.

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http://dx.doi.org/10.1038/s41586-018-0088-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6168194PMC
May 2018

Establishment of human pluripotent stem cell-derived pancreatic β-like cells in the mouse pancreas.

Proc Natl Acad Sci U S A 2018 04 29;115(15):3924-3929. Epub 2018 Mar 29.

Whitehead Institute for Biomedical Research, Cambridge, MA 02142;

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http://dx.doi.org/10.1073/pnas.1702059115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5899428PMC
April 2018

Resolving Discrepant Findings on ANGPTL8 in β-Cell Proliferation: A Collaborative Approach to Resolving the Betatrophin Controversy.

PLoS One 2016 13;11(7):e0159276. Epub 2016 Jul 13.

McNair Medical Institute, Pediatric Diabetes and Endocrinology, Baylor College of Medicine, Texas Children's Hospital, Houston, Texas, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0159276PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4943640PMC
August 2017

Retraction Notice to: Betatrophin: A Hormone that Controls Pancreatic β Cell Proliferation.

Cell 2017 01 28;168(1-2):326. Epub 2016 Dec 28.

Department of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Howard Hughes Medical Institute, Harvard University, 7 Divinity Avenue, Cambridge, MA 02138, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2016.12.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5287220PMC
January 2017

Applied Developmental Biology: Making Human Pancreatic Beta Cells for Diabetics.

Authors:
Douglas A Melton

Curr Top Dev Biol 2016 20;117:65-73. Epub 2016 Jan 20.

Department of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Harvard University, Cambridge, Massachusetts, USA. Electronic address:

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http://dx.doi.org/10.1016/bs.ctdb.2015.11.013DOI Listing
December 2016

Generation of stem cell-derived β-cells from patients with type 1 diabetes.

Nat Commun 2016 05 10;7:11463. Epub 2016 May 10.

Department of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Harvard University 7 Divinity Avenue, Cambridge, Massachusetts 02138, USA.

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http://dx.doi.org/10.1038/ncomms11463DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4866045PMC
May 2016

Testing pancreatic islet function at the single cell level by calcium influx with associated marker expression.

PLoS One 2015 8;10(4):e0122044. Epub 2015 Apr 8.

Department of Stem Cell and Regenerative Biology, Harvard University, Harvard Stem Cell Institute, Cambridge, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0122044PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4390334PMC
March 2016

Angptl4 links α-cell proliferation following glucagon receptor inhibition with adipose tissue triglyceride metabolism.

Proc Natl Acad Sci U S A 2015 Dec 30;112(50):15498-503. Epub 2015 Nov 30.

Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138.

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http://dx.doi.org/10.1073/pnas.1513872112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4687559PMC
December 2015

A Src inhibitor regulates the cell cycle of human pluripotent stem cells and improves directed differentiation.

J Cell Biol 2015 Sep;210(7):1257-68

Department of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Cambridge, MA 02138 Howard Hughes Medical Institute, Harvard University, Cambridge, MA 02138

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http://dx.doi.org/10.1083/jcb.201502035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4586752PMC
September 2015

Modeling human nutrition using human embryonic stem cells.

Cell 2015 Mar;161(1):12-17

Department of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Harvard University, 7 Divinity Avenue, Cambridge MA, USA.

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http://dx.doi.org/10.1016/j.cell.2015.02.039DOI Listing
March 2015

MARIS: method for analyzing RNA following intracellular sorting.

PLoS One 2014 3;9(3):e89459. Epub 2014 Mar 3.

The Harvard Department of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Harvard University, Cambridge, Massachusetts, United States of America; Howard Hughes Medical Institute, Harvard University, Cambridge, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0089459PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3940959PMC
January 2015

Covalent adduct formation between the antihypertensive drug hydralazine and abasic sites in double- and single-stranded DNA.

Chem Res Toxicol 2014 Dec 18;27(12):2113-8. Epub 2014 Nov 18.

Department of Chemistry, ‡Department of Biochemistry, University of Missouri , 125 Chemistry Building, Columbia, Missouri 65211, United States.

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http://dx.doi.org/10.1021/tx5003657DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4269403PMC
December 2014

Generation of functional human pancreatic β cells in vitro.

Cell 2014 Oct;159(2):428-39

Department of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Harvard University, 7 Divinity Avenue, Cambridge, MA 02138, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2014.09.040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4617632PMC
October 2014

Perspectives on the activities of ANGPTL8/betatrophin.

Cell 2014 Oct;159(3):467-8

Department of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Howard Hughes Medical Institute, Harvard University, 7 Divinity Avenue, Cambridge, MA 02138, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2014.09.028DOI Listing
October 2014

Reversal of β cell de-differentiation by a small molecule inhibitor of the TGFβ pathway.

Elife 2014 Sep 16;3:e02809. Epub 2014 Sep 16.

Department of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Harvard University, Cambridge, United States.

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http://dx.doi.org/10.7554/eLife.02809DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4204634PMC
September 2014

Differentiated human stem cells resemble fetal, not adult, β cells.

Proc Natl Acad Sci U S A 2014 Feb 10;111(8):3038-43. Epub 2014 Feb 10.

Department of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute and Howard Hughes Medical Institute, Harvard University, Cambridge, MA 02138.

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http://dx.doi.org/10.1073/pnas.1400709111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3939927PMC
February 2014

In vivo reprogramming of pancreatic acinar cells to three islet endocrine subtypes.

Elife 2014 Jan 1;3:e01846. Epub 2014 Jan 1.

Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, United States.

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https://elifesciences.org/articles/01846
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3977343PMC
http://dx.doi.org/10.7554/eLife.01846DOI Listing
January 2014

Brief report: VGLL4 is a novel regulator of survival in human embryonic stem cells.

Stem Cells 2013 Dec;31(12):2833-41

Department of Stem Cell and Regenerative Biology, Howard Hughes Medical Institute, Harvard Stem Cell Institute, Harvard University, Cambridge, Massachusetts, USA.

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http://dx.doi.org/10.1002/stem.1445DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4617635PMC
December 2013

A simple tool to improve pluripotent stem cell differentiation.

Nat Methods 2013 Jun 14;10(6):553-6. Epub 2013 Apr 14.

Department of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Cambridge, Massachusetts, USA.

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http://dx.doi.org/10.1038/nmeth.2442DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3694177PMC
June 2013

How to make a functional β-cell.

Development 2013 Jun;140(12):2472-83

Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA.

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http://dev.biologists.org/cgi/doi/10.1242/dev.093187
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http://dx.doi.org/10.1242/dev.093187DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3666377PMC
June 2013

Betatrophin: a hormone that controls pancreatic β cell proliferation.

Cell 2013 May 25;153(4):747-58. Epub 2013 Apr 25.

Department of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Howard Hughes Medical Institute, Harvard University, Cambridge, MA 02138, USA.

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http://dx.doi.org/10.1016/j.cell.2013.04.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3756510PMC
May 2013

New findings in pancreatic and intestinal endocrine development to advance regenerative medicine.

Curr Opin Endocrinol Diabetes Obes 2013 Feb;20(1):1-7

Gastrointestinal Unit, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1097/MED.0b013e32835bc380DOI Listing
February 2013

Functional evaluation of ES cell-derived endodermal populations reveals differences between Nodal and Activin A-guided differentiation.

Development 2013 Feb;140(3):675-86

Department of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA.

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http://dx.doi.org/10.1242/dev.085431DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3561793PMC
February 2013

Self-renewal of embryonic-stem-cell-derived progenitors by organ-matched mesenchyme.

Nature 2012 Nov 7;491(7426):765-8. Epub 2012 Oct 7.

Department of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Harvard University, 7 Divinity Avenue, Cambridge, Massachusetts 02138, USA.

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http://dx.doi.org/10.1038/nature11463DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6005657PMC
November 2012

Wnt signaling specifies and patterns intestinal endoderm.

Mech Dev 2011 Sep-Dec;128(7-10):387-400. Epub 2011 Aug 10.

Brigham and Women's Hospital and Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.mod.2011.07.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3223331PMC
March 2012

Adenosine kinase inhibition selectively promotes rodent and porcine islet β-cell replication.

Proc Natl Acad Sci U S A 2012 Mar 15;109(10):3915-20. Epub 2012 Feb 15.

Department of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Cambridge, MA 02138, USA.

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http://dx.doi.org/10.1073/pnas.1201149109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3309788PMC
March 2012

Functional beta-cell maturation is marked by an increased glucose threshold and by expression of urocortin 3.

Nat Biotechnol 2012 02 26;30(3):261-4. Epub 2012 Feb 26.

Department of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Harvard University, Cambridge, Massachusetts, USA.

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http://dx.doi.org/10.1038/nbt.2141DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4617627PMC
February 2012

Turning straw into gold: directing cell fate for regenerative medicine.

Nat Rev Genet 2011 Apr 9;12(4):243-52. Epub 2011 Mar 9.

Department of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Harvard University, 7 Divinity Avenue, Cambridge, Massachusetts 02138, USA.

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http://dx.doi.org/10.1038/nrg2938DOI Listing
April 2011

How to make beta cells?

Curr Opin Cell Biol 2009 Dec 24;21(6):727-32. Epub 2009 Sep 24.

Harvard Stem Cell Institute, Department of Stem Cell and Regeneration Biology, Harvard University, Cambridge, MA 02138, USA.

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http://dx.doi.org/10.1016/j.ceb.2009.08.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4617625PMC
December 2009

Generation of pluripotent stem cells from patients with type 1 diabetes.

Proc Natl Acad Sci U S A 2009 Sep 31;106(37):15768-73. Epub 2009 Aug 31.

Department of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Harvard University, 7 Divinity Avenue, Cambridge, MA 02138, USA.

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http://dx.doi.org/10.1073/pnas.0906894106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2735559PMC
September 2009

Notch signaling promotes airway mucous metaplasia and inhibits alveolar development.

Development 2009 May 15;136(10):1751-9. Epub 2009 Apr 15.

Department of Stem Cell and Regenerative Biology, Howard Hughes Medical Institute, Harvard University, Cambridge, MA 02138, USA.

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http://dx.doi.org/10.1242/dev.029249DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2673763PMC
May 2009

A small molecule that directs differentiation of human ESCs into the pancreatic lineage.

Nat Chem Biol 2009 Apr 15;5(4):258-65. Epub 2009 Mar 15.

Department of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Cambridge, Massachusetts, USA.

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http://dx.doi.org/10.1038/nchembio.154DOI Listing
April 2009

Derivation of human embryonic stem cells by immunosurgery.

J Vis Exp 2007 13(10):574. Epub 2007 Dec 13.

Dept. of Molecular and Cellular Biology, Harvard University, USA.

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http://dx.doi.org/10.3791/574DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2557078PMC
February 2009

Transcriptional dynamics of endodermal organ formation.

Dev Dyn 2009 Jan;238(1):29-42

Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA.

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http://dx.doi.org/10.1002/dvdy.21810DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3756511PMC
January 2009

Induction of pluripotent stem cells from primary human fibroblasts with only Oct4 and Sox2.

Nat Biotechnol 2008 Nov 12;26(11):1269-75. Epub 2008 Oct 12.

Department of Stem Cell and Regenerative Biology, Howard Hughes Medical Institute, Harvard Stem Cell Institute, Harvard University, 7 Divinity Avenue, Cambridge, Massachusetts 02138, USA.

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http://www.nature.com/articles/nbt.1502
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http://dx.doi.org/10.1038/nbt.1502DOI Listing
November 2008

In vivo reprogramming of adult pancreatic exocrine cells to beta-cells.

Nature 2008 Oct 27;455(7213):627-32. Epub 2008 Aug 27.

Department of Stem Cell and Regenerative Biology, Howard Hughes Medical Institute, Harvard Stem Cell Institute, Harvard University, 7 Divinity Avenue, Cambridge, Massachusetts 02138, USA.

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http://dx.doi.org/10.1038/nature07314DOI Listing
October 2008

Extreme makeover: converting one cell into another.

Cell Stem Cell 2008 Oct;3(4):382-8

Department of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, HHMI, Harvard University, 7 Divinity Avenue, Cambridge, MA 02138, USA.

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http://dx.doi.org/10.1016/j.stem.2008.09.015DOI Listing
October 2008

Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds.

Nat Biotechnol 2008 Jul 22;26(7):795-7. Epub 2008 Jun 22.

Department of Stem Cell and Regenerative Biology, Howard Hughes Medical Institute, Harvard Stem Cell Institute, Harvard University, 7 Divinity Avenue, Cambridge, Massachusetts 02138, USA.

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http://dx.doi.org/10.1038/nbt1418DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334647PMC
July 2008

Wnt7b stimulates embryonic lung growth by coordinately increasing the replication of epithelium and mesenchyme.

Development 2008 May 26;135(9):1625-34. Epub 2008 Mar 26.

Department of Molecular and Cellular Biology, Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA.

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http://dx.doi.org/10.1242/dev.015495DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2556060PMC
May 2008

Marked differences in differentiation propensity among human embryonic stem cell lines.

Nat Biotechnol 2008 Mar 17;26(3):313-5. Epub 2008 Feb 17.

Harvard Stem Cell Institute, 42 Church Street, Cambridge, Massachusetts 02138, USA.

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http://dx.doi.org/10.1038/nbt1383DOI Listing
March 2008

Genetic targeting of the endoderm with claudin-6CreER.

Dev Dyn 2008 Feb;237(2):504-12

Department of Molecular and Cellular Biology, Howard Hughes Medical Institute, Harvard Stem Cell Institute, Harvard University, Cambridge, Massachusetts 02138, USA.

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http://dx.doi.org/10.1002/dvdy.21437DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2665265PMC
February 2008

Facultative endocrine progenitor cells in the adult pancreas.

Cell 2008 Jan;132(2):183-4

Department of Cellular Biochemistry and Human Genetics, The Hebrew University-Hadassah Medical School, Jerusalem 91120, Israel.

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http://dx.doi.org/10.1016/j.cell.2008.01.004DOI Listing
January 2008

A gene regulatory network in mouse embryonic stem cells.

Proc Natl Acad Sci U S A 2007 Oct 10;104(42):16438-43. Epub 2007 Oct 10.

Department of Statistics, University of California, Los Angeles, 8125 Math Science Building, Los Angeles, CA 90095, USA.

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http://dx.doi.org/10.1073/pnas.0701014104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2034259PMC
October 2007

Recovery from diabetes in mice by beta cell regeneration.

J Clin Invest 2007 Sep;117(9):2553-61

Department of Cellular Biochemistry and Human Genetics, Hebrew University-Hadassah Medical School, Jerusalem, Israel.

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http://dx.doi.org/10.1172/JCI32959DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1957545PMC
September 2007

A multipotent progenitor domain guides pancreatic organogenesis.

Dev Cell 2007 Jul;13(1):103-14

Department of Molecular and Cellular Biology, Howard Hughes Medical Institute, Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA.

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http://dx.doi.org/10.1016/j.devcel.2007.06.001DOI Listing
July 2007

Prospective isolation and global gene expression analysis of definitive and visceral endoderm.

Dev Biol 2007 Apr 12;304(2):541-55. Epub 2007 Jan 12.

Department of Molecular and Cellular Biology, Harvard Stem Cell Institute, Harvard University, 7 Divinity Ave, Cambridge, MA 02138, USA.

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http://dx.doi.org/10.1016/j.ydbio.2007.01.011DOI Listing
April 2007

Notch signaling reveals developmental plasticity of Pax4(+) pancreatic endocrine progenitors and shunts them to a duct fate.

Mech Dev 2007 Feb 17;124(2):97-107. Epub 2006 Nov 17.

Department of Molecular and Cellular Biology, Harvard University, 7 Divinity Avenue, Cambridge, MA 02138, USA.

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http://dx.doi.org/10.1016/j.mod.2006.11.002DOI Listing
February 2007

Organ size is limited by the number of embryonic progenitor cells in the pancreas but not the liver.

Nature 2007 Feb 28;445(7130):886-91. Epub 2007 Jan 28.

Department of Molecular and Cellular Biology, Harvard Stem Cell Institute, and Howard Hughes Medical Institute, Cambridge, Massachusetts 02138, USA.

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http://dx.doi.org/10.1038/nature05537DOI Listing
February 2007

Human embryonic stem cells.

Methods Enzymol 2006 ;418:78-92

Harvard University, Howard Huges Medical Institute, Cambridge, Massachusetts, USA.

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http://dx.doi.org/10.1016/S0076-6879(06)18005-2DOI Listing
January 2007

Reversal of type 1 diabetes in mice.

Authors:
Douglas A Melton

N Engl J Med 2006 Jul;355(1):89-90

Harvard Stem Cell Institute, Department of Molecular and Cellular Biology, Harvard University, Boston, USA.

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http://dx.doi.org/10.1056/NEJMcibr062559DOI Listing
July 2006

Beta-catenin is essential for pancreatic acinar but not islet development.

Development 2005 Nov 28;132(21):4663-74. Epub 2005 Sep 28.

Department of Molecular and Cellular Biology and Howard Hughes Medical Institute, Harvard University, Cambridge, MA 02138, USA.

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http://dx.doi.org/10.1242/dev.02063DOI Listing
November 2005

Pten constrains centroacinar cell expansion and malignant transformation in the pancreas.

Cancer Cell 2005 Sep;8(3):185-95

Howard Hughes Medical Institute and the Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA.

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http://dx.doi.org/10.1016/j.ccr.2005.07.015DOI Listing
September 2005

Direct regulation of intestinal fate by Notch.

Proc Natl Acad Sci U S A 2005 Aug 17;102(35):12443-8. Epub 2005 Aug 17.

Howard Hughes Medical Institute and Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA.

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http://www.pnas.org/content/102/35/12443.full.pdf
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http://www.pnas.org/cgi/doi/10.1073/pnas.0505690102
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http://dx.doi.org/10.1073/pnas.0505690102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1194941PMC
August 2005

Nuclear reprogramming of somatic cells after fusion with human embryonic stem cells.

Science 2005 Aug;309(5739):1369-73

Howard Hughes Medical Institute, Harvard Stem Cell Institute, Department of Molecular and Cellular Biology, Harvard University, 7 Divinity Avenue, Cambridge, MA 02138, USA.

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http://dx.doi.org/10.1126/science.1116447DOI Listing
August 2005

The molecular biography of the cell.

Cell 2005 Mar;120(6):729-31

Neuroendocrine Unit, Bulfinch 457, Massachusetts General Hospital, 55 Fruit Street, Boston, Massachusetts 02114, USA.

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http://dx.doi.org/10.1016/j.cell.2005.03.002DOI Listing
March 2005

Altered nuclear transfer in stem-cell research - a flawed proposal.

N Engl J Med 2004 Dec;351(27):2791-2

Harvard Stem Cell Institute, Boston, MA, USA.

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http://dx.doi.org/10.1056/NEJMp048348DOI Listing
December 2004

Artifactual insulin release from differentiated embryonic stem cells.

Diabetes 2004 Oct;53(10):2603-9

Department of Developmental Biology, Hagedorn Research Institute, Niels Steensens vej 6, DK-2820 Gentofte, Denmark.

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http://dx.doi.org/10.2337/diabetes.53.10.2603DOI Listing
October 2004

How important are adult stem cells for tissue maintenance?

Cell Cycle 2004 Sep 19;3(9):1104-6. Epub 2004 Sep 19.

Howard Hughes Medical Institute, Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA.

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September 2004

The Src family of tyrosine kinases is important for embryonic stem cell self-renewal.

J Biol Chem 2004 Jul 17;279(30):31590-8. Epub 2004 May 17.

Howard Hughes Medical Institute and Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA.

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http://dx.doi.org/10.1074/jbc.M403547200DOI Listing
July 2004

Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation.

Nature 2004 May;429(6987):41-6

Department of Molecular and Cellular Biology and Howard Hughes Medical Institute, Harvard University, 7 Divinity Avenue, Cambridge, Massachusetts 02138, USA.

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http://dx.doi.org/10.1038/nature02520DOI Listing
May 2004

Derivation of embryonic stem-cell lines from human blastocysts.

N Engl J Med 2004 Mar 3;350(13):1353-6. Epub 2004 Mar 3.

Howard Hughes Medical Institute, Cambridge, Mass, USA.

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http://dx.doi.org/10.1056/NEJMsr040330DOI Listing
March 2004

Genes, signals, and lineages in pancreas development.

Annu Rev Cell Dev Biol 2003 ;19:71-89

Department of Molecular and Cellular Biology, Howard Hughes Medical Institute, Harvard University, 7 Divinity Avenue, Cambridge, Massachusetts 02138, USA.

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http://dx.doi.org/10.1146/annurev.cellbio.19.111301.144752DOI Listing
February 2004

Global expression analysis of gene regulatory pathways during endocrine pancreatic development.

Development 2004 Jan 3;131(1):165-79. Epub 2003 Dec 3.

Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA.

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http://dx.doi.org/10.1242/dev.00921DOI Listing
January 2004

Notch signaling controls multiple steps of pancreatic differentiation.

Proc Natl Acad Sci U S A 2003 Dec 1;100(25):14920-5. Epub 2003 Dec 1.

Howard Hughes Medical Institute and Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA.

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http://dx.doi.org/10.1073/pnas.2436557100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC299853PMC
December 2003

Endothelial signaling during development.

Nat Med 2003 Jun;9(6):661-8

Howard Hughes Medical Institute and Department of Cellular and Molecular Biology, Harvard University, 7 Divinity Ave, Cambridge, Massachusetts 02138, USA.

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http://dx.doi.org/10.1038/nm0603-661DOI Listing
June 2003

Role of VEGF-A in vascularization of pancreatic islets.

Curr Biol 2003 Jun;13(12):1070-4

Max-Planck Institute of Molecular Cell Biology and Genetics, 01307 Dresden, Germany.

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http://dx.doi.org/10.1016/s0960-9822(03)00378-6DOI Listing
June 2003

Single-cell transcript analysis of pancreas development.

Dev Cell 2003 Mar;4(3):383-93

Department of Molecular and Cellular Biology, Howard Hughes Medical Institute, Harvard University, 7 Divinity Avenue, Cambridge, MA 02138, USA.

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March 2003

Direct lineage tracing reveals the ontogeny of pancreatic cell fates during mouse embryogenesis.

Mech Dev 2003 Jan;120(1):35-43

Department of Molecular and Cell Biology, Howard Hughes Medical Institute, Harvard University, Cambridge, MA 02138, USA.

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http://dx.doi.org/10.1016/s0925-4773(02)00330-1DOI Listing
January 2003

Role of endothelial cells in early pancreas and liver development.

Mech Dev 2003 Jan;120(1):59-64

Department of Molecular and Cellular Biology, Harvard University, 7 Divinity Avenue, Cambridge, MA 02138, USA.

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http://dx.doi.org/10.1016/s0925-4773(02)00332-5DOI Listing
January 2003

Insulin staining of ES cell progeny from insulin uptake.

Science 2003 Jan;299(5605):363

Department of Molecular and Cellular Biology, Howard Hughes Medical Institute, Harvard University, 7 Divinity Avenue, Cambridge, MA 02138, USA.

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http://dx.doi.org/10.1126/science.1077838DOI Listing
January 2003

"Stemness": transcriptional profiling of embryonic and adult stem cells.

Science 2002 Oct 12;298(5593):597-600. Epub 2002 Sep 12.

Department of Molecular and Cellular Biology and Howard Hughes Medical Institute (HHMI), Harvard University, Cambridge, MA 02138, USA.

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http://www.sciencemag.org/cgi/doi/10.1126/science.1072530
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http://dx.doi.org/10.1126/science.1072530DOI Listing
October 2002