Douglas L Arnold

Douglas L Arnold

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Douglas L Arnold

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White matter plasticity and maturation in human cognition.

Glia 2019 Nov 24;67(11):2020-2037. Epub 2019 Jun 24.

Neurosciences and Mental Health Program, Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/glia.23661DOI Listing
November 2019

High serum neurofilament light chain normalizes after hematopoietic stem cell transplantation for MS.

Neurol Neuroimmunol Neuroinflamm 2019 Sep 8;6(5):e598. Epub 2019 Aug 8.

The University of Ottawa and Ottawa Hospital Research Institute (S.T., M.B., H.L.A., M.S.F.); Department of Physics (D.R.T., V.T.-C.), University of Ottawa; Montreal Neurological Institute (H.L., D.L.A.); and Perelman School of Medicine and University of Pennsylvania (A.B.-O.).

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http://dx.doi.org/10.1212/NXI.0000000000000598DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6715458PMC
September 2019

Early neuroaxonal injury is seen in the acute phase of pediatric optic neuritis.

Mult Scler Relat Disord 2019 Sep 7;36:101387. Epub 2019 Sep 7.

Division of Neurosciences and Mental Health, SickKids Research Institute, Toronto, Ontario, Canada; Division of Neurology, Department of Pediatrics, The Hospital for Sick Children, Toronto, Ontario, Canada; Department of Pediatrics (Neurology), University of Toronto, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.msard.2019.101387DOI Listing
September 2019

Detection and clinical correlation of leukocortical lesions in pediatric-onset multiple sclerosis on multi-contrast MRI.

Mult Scler 2019 Jun 1;25(7):980-986. Epub 2018 Jun 1.

Departments of Neurology and Neurosurgery, Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada.

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http://dx.doi.org/10.1177/1352458518779952DOI Listing
June 2019

Placebo-Controlled Trial of an Oral BTK Inhibitor in Multiple Sclerosis.

N Engl J Med 2019 06 10;380(25):2406-2417. Epub 2019 May 10.

From Vall d'Hebron University Hospital, Barcelona (X.M.); St. Michael's Hospital, University of Toronto, Toronto (X.M.), and Montreal Neurological Institute and NeuroRx Research, Montreal (D.L.A.) - both in Canada; the Institute of Neuropathology and the Department of Neurology, University Medical Center, Göttingen, Germany (M.S.W.); the Department of Neurology, Acibadem City Clinic Tokuda Hospital, Sofia, Bulgaria (I.S.); the Department of Histology and Embryology, Poznan University of Medical Science, Poznan, Poland (K.P.-S.); the Global Clinical Development Center, EMD Serono Research and Development Institute, Billerica, MA (J.W., E.M., F.D., S.S.); and McGovern Medical School, University of Texas Health Science Center at Houston, Houston (J.S.W.).

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http://dx.doi.org/10.1056/NEJMoa1901981DOI Listing
June 2019

High rates of health care utilization in pediatric multiple sclerosis: A Canadian population-based study.

PLoS One 2019 11;14(6):e0218215. Epub 2019 Jun 11.

Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0218215PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6559708PMC
June 2019

Effect of dimethyl fumarate on lymphocytes in RRMS: Implications for clinical practice.

Neurology 2019 Apr 27;92(15):e1724-e1738. Epub 2019 Mar 27.

From Biogen (D.M., C.M., E.B., J.H., S.L., A.M., C.A.v.H., L.Y.), Cambridge, MA; NeuroRx Research (D.L.A.), Montreal; Montreal Neurological Institute (D.L.A.), McGill University, Montreal, Canada; Center for Neuroinflammation and Experimental Therapeutics and Department of Neurology (A.B.-O.), Perelman School of Medicine, University of Pennsylvania, Philadelphia; Department of Neurology (R.G.), St. Josef Hospital, Ruhr University, Bochum, Germany; Department of Neurology (L.K.), University Hospital Basel, Switzerland; University of New Mexico Health Sciences Center (J.T.P.), Albuquerque; Department of Neurology, Multiple Sclerosis Division (D.R.), Morsani College of Medicine, University of South Florida, Tampa; Mellen Center for Multiple Sclerosis, Neurological Institute (R.J.F.), Cleveland Clinic, OH; Envision Pharma Group (J.C.), Sydney, Australia; and Envision Pharma Group (K.S.), Southport, CT.

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http://dx.doi.org/10.1212/WNL.0000000000007262DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6511089PMC
April 2019

A surface-in gradient of thalamic damage evolves in pediatric multiple sclerosis.

Ann Neurol 2019 Mar 20;85(3):340-351. Epub 2019 Feb 20.

Department of Neurology, Perelman Center for Advanced Medicine, University of Pennsylvania, Philadelphia, PA.

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http://dx.doi.org/10.1002/ana.25429DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6593844PMC
March 2019

Abnormal effector and regulatory T cell subsets in paediatric-onset multiple sclerosis.

Brain 2019 Mar;142(3):617-632

Neuroimmunology Unit, Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, 3801 University Street, Suite # 111, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1093/brain/awz017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391601PMC
March 2019

Imaging outcome measures of neuroprotection and repair in MS: A consensus statement from NAIMS.

Neurology 2019 Mar 20;92(11):519-533. Epub 2019 Feb 20.

From the Division of Neurology (J.O.), St. Michael's Hospital, University of Toronto, Canada; Department of Neurology (J.O., P.A.C., B.D., D.S.R.), Johns Hopkins University, Baltimore, MD; Mellen Center for Multiple Sclerosis (D.O.), Cleveland Clinic, OH; Department of Neurology (C.A., D.P.), University of Southern California, Los Angeles; Department of Neurology (E.C.K.), Massachusetts General Hospital, Harvard Medical School, Boston; Translational Neuroradiology Unit (M.A., G.N., P.S., D.S.R.), National Institute of Neurological Disorders and Stroke, Bethesda, MD; Brain Imaging Centre (D.L.A., S.N.), Montreal Neurological Institute, McGill University, Canada; Departments of Neurology (R.B.) and Radiology (R.B.), Brigham and Women's Hospital, Harvard Medical School, Boston; Department of Biostatistics (C.C.), Johns Hopkins School of Public Health, Baltimore, MD; Department of Neurology (L.F.), University of Texas Health Science Center at Houston; Department of Neurology (S.G., Y.W.), Weill Cornell Medical College, Cornell University, Ithaca, NY; Department of Neurology (R.H.), University of California at San Francisco; Department of Neurology (M.I., A.T.), Mount Sinai Hospital, New York, NY; Division of Neurology, Department of Medicine (S.K., D.K.B.L.), Department of Radiology (S.K., D.K.B.L., A.R.), Department of Physics and Astronomy (S.K., A.R., A.T., Y.Y.), MS/MRI Research Group (S.K., D.K.B.L., A.T., Y.Y.), MRI Research Centre (S.K., D.K.B.L., A.R.), and Department of Pediatrics (A.R.), University of British Columbia, Vancouver, Canada; A. A. Martinos Center for Biomedical Imaging (C.M.), Department of Radiology, Massachusetts General Hospital, Boston; Centre for Functional and Metabolic Mapping (R.S.M.), Robarts Research Institute, Western University, London, CA; Department of Neurology (F.N.), University of Minnesota, Minneapolis; Advanced Imaging Research Center (W.R., D.S., I.T.), Oregon Health & Science University, Portland; Department of Biostatistics, Epidemiology, and Informatics (R.T.S.), University of Pennsylvania Perelman School of Medicine, Philadelphia; Division of Neuroradiology and Neurophysics (T.Y.), University College London Institute of Neurology, UK; Department of Radiology (Y.Z.) and Department of Clinical Neurosciences and Hotchkiss Brain Institute (Y.Z.), University of Calgary, Canada; and Department of Neurology (N.L.S.), Cedars-Sinai Medical Center, Los Angeles, CA.

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http://dx.doi.org/10.1212/WNL.0000000000007099DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6511106PMC
March 2019

Improving the SIENA performance using BEaST brain extraction.

PLoS One 2018 20;13(9):e0196945. Epub 2018 Sep 20.

McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0196945PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6147402PMC
February 2019

Estimating and accounting for the effect of MRI scanner changes on longitudinal whole-brain volume change measurements.

Neuroimage 2019 01 22;184:555-565. Epub 2018 Sep 22.

Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.

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https://linkinghub.elsevier.com/retrieve/pii/S10538119183186
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http://dx.doi.org/10.1016/j.neuroimage.2018.09.062DOI Listing
January 2019

Slowly expanding/evolving lesions as a magnetic resonance imaging marker of chronic active multiple sclerosis lesions.

Mult Scler 2018 Dec 19:1352458518814117. Epub 2018 Dec 19.

NeuroRx Research, Montreal, QC, Canada/Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada.

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http://dx.doi.org/10.1177/1352458518814117DOI Listing
December 2018

Physical activity and dentate gyrus volume in pediatric acquired demyelinating syndromes.

Neurol Neuroimmunol Neuroinflamm 2018 Nov 6;5(6):e499. Epub 2018 Sep 6.

Division of Neurology, Department of Neurosciences and Mental Health (G.L., S.A.G., E.A.Y.), the Hospital for Sick Children, Toronto, ON, Canada; Department of Pediatrics (G.L., H.M.B., E.A.Y.), the University of Toronto, Toronto, ON, Canada; McConnell Brain Imaging Centre (R.A.B., B.A.-B., D.F., D.L.C., S.N., D.L.A.), Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada; Division of Medical Imaging (H.M.B.), the Hospital for Sick Children, Toronto, ON, Canada; Department of Physical Therapy (R.W.M.), University of Alabama at Birmingham, Birmingham, AL; Departments of Internal Medicine and Community Health Sciences (R.A.M.), Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Manitoba, Canada; and Division of Neurology (B.B.), the Children's Hospital of Philadelphia, Perelman School of Medicine (A.B.-O.), University of Pennsylvania, Philadelphia, PA.

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http://nn.neurology.org/lookup/doi/10.1212/NXI.0000000000000
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http://dx.doi.org/10.1212/NXI.0000000000000499DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6131051PMC
November 2018

Incidence and prevalence of MS in children: A population-based study in Ontario, Canada.

Neurology 2018 10 26;91(17):e1579-e1590. Epub 2018 Sep 26.

From the Departments of Internal Medicine and Community Health Sciences (R.A.M.), Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg; Institute of Health Policy, Management and Evaluation (J.O.), University of Toronto, the Hospital for Sick Children; Schools of Pharmacy and Public Health and Health Systems (C.M.), University of Waterloo; Institute for Clinical Evaluative Sciences (C.M., V.L.), Toronto; Department of Pediatrics (E.A.Y.), University of Toronto; Division of Neurology, Neurosciences and Mental Health (E.A.Y.), the Hospital for Sick Children, SickKids Research Institute, Toronto; Montreal Neurological Institute (D.L.A.), McGill University, Montreal, Canada; Center for Neuroinflammation and Experimental Therapeutics and Department of Neurology (A.B.-O.), Perelman School of Medicine (B.B.), University of Pennsylvania, Philadelphia; and Division of Child Neurology (B.B.), the Children's Hospital of Philadelphia, PA.

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http://dx.doi.org/10.1212/WNL.0000000000006395DOI Listing
October 2018

Trial of Fingolimod versus Interferon Beta-1a in Pediatric Multiple Sclerosis.

N Engl J Med 2018 09;379(11):1017-1027

From the Partners Pediatric Multiple Sclerosis Center, Massachusetts General Hospital, Boston (T.C.); Montreal Neurological Institute, McGill University, and NeuroRx Research - both in Montreal (D.L.A.); Children's Hospital of Philadelphia (B.B.) and the Center for Neuroinflammation and Experimental Neurotherapeutics and the Department of Neurology (A.B.-O.), Perelman School of Medicine, University of Pennsylvania - all in Philadelphia; the Department of Neuropathology (W.B.) and the Department of Pediatrics and Adolescent Medicine, German Center for Multiple Sclerosis in Childhood and Adolescence (J.G.), University Medical Center Göttingen, Göttingen, and the Division of Pediatric Neurology, Children's Hospital Datteln, Witten/Herdecke University, Datteln (K.R.) - all in Germany; Gallarate Hospital, Gallarate, Italy (A.G.); Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London (G.G.); the University of Texas Southwestern Medical Center, Children's Health, Dallas (B.G.), and McGovern Medical School, University of Texas Health Science Center at Houston, Houston (J.S.W.) - both in Texas; Pediatric Multiple Sclerosis Center at NYU Langone, New York (L.K.); Hôpitaux Universitaires Paris-Sud, Assistance Publique-Hôpitaux de Paris, Paris (M.T.); the Department of Neurology, University of California at San Francisco, San Francisco (E.W.); Novartis Pharmaceuticals, East Hanover, NJ (T.S., Y.C., N.P.); and Novartis Pharma, Basel, Switzerland (M.M.).

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http://www.nejm.org/doi/10.1056/NEJMoa1800149
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http://dx.doi.org/10.1056/NEJMoa1800149DOI Listing
September 2018

Standardized quality metric system for structural brain magnetic resonance images in multi-center neuroimaging study.

BMC Med Imaging 2018 09 17;18(1):31. Epub 2018 Sep 17.

The Alzheimer's Disease Neuroimaging Initiative, Center for Imaging of Neurodegenerative Disease, San Francisco VA Medical Center, University of California, San Francisco, USA.

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http://dx.doi.org/10.1186/s12880-018-0266-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6142697PMC
September 2018

Long-term outcomes of peginterferon beta-1a in multiple sclerosis: results from the ADVANCE extension study, ATTAIN.

Ther Adv Neurol Disord 2018 28;11:1756286418791143. Epub 2018 Aug 28.

Department of Clinical Neurological Sciences, University of Western Ontario, and London Health Science Centre, London, ON, Canada.

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http://dx.doi.org/10.1177/1756286418791143DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6113734PMC
August 2018

Impact of immunoablation and autologous hematopoietic stem cell transplantation on gray and white matter atrophy in multiple sclerosis.

Mult Scler 2018 07 15;24(8):1055-1066. Epub 2017 Jun 15.

McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, QC, Canada.

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http://journals.sagepub.com/doi/10.1177/1352458517715811
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http://dx.doi.org/10.1177/1352458517715811DOI Listing
July 2018

Blind blur assessment of MRI images using parallel multiscale difference of Gaussian filters.

Biomed Eng Online 2018 Jun 13;17(1):76. Epub 2018 Jun 13.

BrainCare Oy, Finn-Medi 1 PL 2000, 33521, Tampere, Finland.

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http://dx.doi.org/10.1186/s12938-018-0514-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6001176PMC
June 2018

MRI and laboratory features and the performance of international criteria in the diagnosis of multiple sclerosis in children and adolescents: a prospective cohort study.

Lancet Child Adolesc Health 2018 03 1;2(3):191-204. Epub 2018 Feb 1.

Division of Child Neurology, Department of Neurology, The Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S23524642183002
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http://dx.doi.org/10.1016/S2352-4642(18)30026-9DOI Listing
March 2018

Delineation of cortical pathology in multiple sclerosis using multi-surface magnetization transfer ratio imaging.

Neuroimage Clin 2016 13;12:858-868. Epub 2016 Oct 13.

McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada; Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1016/j.nicl.2016.10.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5107650PMC
November 2017

Alemtuzumab CARE-MS I 5-year follow-up: Durable efficacy in the absence of continuous MS therapy.

Neurology 2017 Sep 23;89(11):1107-1116. Epub 2017 Aug 23.

From the Department of Neurology and Center for Clinical Neuroscience (E.H.), First Faculty of Medicine, Charles University and General University Hospital in Prague, Czech Republic; NeuroRx Research (D.L.A.), Montréal; Department of Neurology and Neurosurgery (D.L.A.), Montréal Neurological Institute, McGill University, Québec, Canada; Mellen Center (J.A.C.), Cleveland Clinic, OH; Department of Neurology and Center for Neuropsychiatry (H.-P.H.), Medical Faculty, Heinrich-Heine University, Düsseldorf, Germany; MS Clinic of Central Texas (E.J.F.), Central Texas Neurology Consultants, Round Rock; Queen Mary University of London (G.G.), Barts and The London School of Medicine, UK; Neuroimmunology and Multiple Sclerosis Research (S.S.), Department of Neurology, University Hospital Zürich and University of Zürich, Switzerland; Department of Neurology (K.W.S.), Medical University of Łódź, Poland; The University of British Columbia (A.T.), Vancouver, Canada; Department of Clinical Neurosciences (D.A.S.C., A.J.C.), University of Cambridge, UK; Sanofi (D.H.M., K.T., C.E.R., D.J., M.A.P.), Cambridge, MA; Evidence Scientific Solutions (R.J.H.), Sydney, NSW, Australia; and Evidence Scientific Solutions (P.X.), Philadelphia, PA. M.A.P. is currently affiliated with Wave Life Sciences, Cambridge, MA.

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http://dx.doi.org/10.1212/WNL.0000000000004313DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5595278PMC
September 2017

Alemtuzumab CARE-MS II 5-year follow-up: Efficacy and safety findings.

Neurology 2017 Sep 23;89(11):1117-1126. Epub 2017 Aug 23.

From the Department of Clinical Neurosciences (A.J.C., D.A.S.C.), University of Cambridge, UK; Mellen Center (J.A.C.), Cleveland Clinic, OH; MS Clinic of Central Texas (E.J.F.), Central Texas Neurology Consultants, Round Rock; Queen Mary University of London (G.G.), Barts and the London School of Medicine, UK; Department of Neurology and Center for Neuropsychiatry (H.-P.H.), Medical Faculty, Heinrich-Heine University, Düsseldorf, Germany; Department of Neurology and Center for Clinical Neuroscience (E.H.), First Faculty of Medicine, Charles University and General Hospital in Prague, Czech Republic; Neuroimmunology and Multiple Sclerosis Research, Department of Neurology (S.S.), University Hospital Zürich and University of Zürich, Switzerland; Department of Neurology (K.W.S.), Medical University of Łódź, Poland; The University of British Columbia (A.T.), Vancouver, Canada; Sanofi (D.H.M., K.T., M.C.C., D.J., M.A.P.), Cambridge, MA; Envision Scientific Solutions (P.X.), Philadelphia, PA; Envision Scientific Solutions (R.J.H.), Sydney, NSW, Australia; NeuroRx Research (D.L.A.), Montréal; Department of Neurology and Neurosurgery (D.L.A.), Montréal Neurological Institute, McGill University, Québec, Canada. M.A.P. is currently affiliated with Wave Life Sciences, Cambridge, MA.

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http://dx.doi.org/10.1212/WNL.0000000000004354DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5595276PMC
September 2017

MRI evidence of acute inflammation in leukocortical lesions of patients with early multiple sclerosis.

Neurology 2017 Aug 19;89(7):714-721. Epub 2017 Jul 19.

From the Department of Neurology and Neurosurgery (J.M., D.A.R., K.N., D.L.A., S.N.), Montreal Neurological Hospital and Institute, McGill University, Canada; Cleveland Clinic (K.N.), OH; Rutgers-New Jersey Medical School (S.C., D.C.), Newark, NJ; and Case Western Reserve University (L.W.), Cleveland, OH. L.W. is currently with the University of Connecticut, School of Medicine, Farmington.

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http://dx.doi.org/10.1212/WNL.0000000000004227DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5562966PMC
August 2017

White matter changes in paediatric multiple sclerosis and monophasic demyelinating disorders.

Brain 2017 May;140(5):1300-1315

McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada.

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http://dx.doi.org/10.1093/brain/awx041DOI Listing
May 2017

Monophasic demyelination reduces brain growth in children.

Neurology 2017 May 5;88(18):1744-1750. Epub 2017 Apr 5.

From the McConnell Brain Imaging Center (B.A.-B., K.W., V.S.F., S.N., D.L.A., D.L.C.) and Department of Neurology and Neurosurgery and Experimental Therapeutics Program (A.B.-O.), Montreal Neurological Institute, McGill University; The Hospital for Sick Children (G.L., E.A.Y., L.H.V.), University of Toronto; Departments of Internal Medicine and Community Health Sciences (R.A.M.), University of Manitoba, Winnipeg, Canada; and Children's Hospital of Philadelphia (B.B.), Perelman School of Medicine, University of Pennsylvania.

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http://dx.doi.org/10.1212/WNL.0000000000003884DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5409842PMC
May 2017

Brain atrophy after bone marrow transplantation for treatment of multiple sclerosis.

Mult Scler 2017 Mar 11;23(3):420-431. Epub 2016 Jul 11.

McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, QC, Canada.

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http://dx.doi.org/10.1177/1352458516650992DOI Listing
March 2017

Corrigendum to "Intracortical inhibition abnormality during the remission phase of multiple sclerosis is related to upper limb dexterity and lesions" [Clin. Neurophysiol. 127 (2016) 1503-1511].

Clin Neurophysiol 2017 02 7;128(2):393. Epub 2017 Jan 7.

Research Institute of the McGill University Health Centre, 2155 Guy Street, 5th Floor, Montreal, Que. H3H 2R9, Canada; Department of Neurology and Neurosurgery, McGill University, 845 Rue Sherbrooke Ouest, Montréal, Que., Canada.

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http://dx.doi.org/10.1016/j.clinph.2016.11.022DOI Listing
February 2017

High-dose immunosuppressive therapy and autologous HCT for relapsing-remitting MS.

Neurology 2017 Feb 1;88(9):842-852. Epub 2017 Feb 1.

From the Colorado Blood Cancer Institute (R.A.N.), Denver; Baylor College of Medicine (G.J.H.), Houston, TX; Ohio State University (M.K.R., S.M.D.), Columbus; MD Anderson Cancer Research Center (U.P.), Houston, TX; Rho, Inc. (K.C.S.), Chapel Hill, NC; National Institute of Allergy and Infectious Diseases (L.M.G.), National Institutes of Health, Bethesda, MD; Division of Brain Sciences (P.A.M.), Imperial College London, UK; City of Hope National Medical Center (H.O.), Duarte, CA; Immune Tolerance Network (P.H.S.), University of California San Francisco; University of Texas Southwestern (O.S.), Dallas; NeuroRx (D.L.A.), McGill University, Montreal, Canada; Fred Hutchinson Cancer Research Center (G.E.G.), University of Washington (M.H.W., A.W., G.H.K.); and Swedish Hospital Medical Center (J.D.B.), Seattle, WA.

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http://dx.doi.org/10.1212/WNL.0000000000003660DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5331868PMC
February 2017

Ocrelizumab versus Interferon Beta-1a in Relapsing Multiple Sclerosis.

N Engl J Med 2017 01 21;376(3):221-234. Epub 2016 Dec 21.

From the University of California, San Francisco (S.L.H.), and Genentech, South San Francisco (D.M., P.C., H.G.) - both in California; McGill University (A.B.-O., D.L.A.) and NeuroRx Research (D.L.A.), Montreal, and University of British Columbia, Vancouver, BC (A.T.) - both in Canada; University Vita-Salute San Raffaele, Milan (G.C.); Barts and the London School of Medicine and Dentistry, London (G.G.); Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf (H.-P.H.), and the Technical University of Munich and Munich Cluster for Systems Neurology, Munich (B.H.) - both in Germany; Icahn School of Medicine at Mount Sinai, New York (F.L.); Hospital Vall d'Hebron University, Barcelona (X.M.); University of Miami, Miami (K.W.R.); Medical University of Lodz and Center for Neurology, Lodz, Poland (K.S.); McGovern Medical School, University of Texas Health Science Center at Houston, Houston (J.S.W.); and F. Hoffmann-La Roche (G.K., P.F., S.B., N.M.) and University Hospital Basel, University of Basel (L.K.), Basel, Switzerland.

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http://dx.doi.org/10.1056/NEJMoa1601277DOI Listing
January 2017

Ocrelizumab versus Placebo in Primary Progressive Multiple Sclerosis.

N Engl J Med 2017 01 21;376(3):209-220. Epub 2016 Dec 21.

From Hospital Vall d'Hebron University, Barcelona (X.M.); University of California, San Francisco, San Francisco (S.L.H.), and Genentech, South San Francisco (D.M., H.G., P.C.) - both in California; University Hospital Basel, University of Basel (L.K.), and F. Hoffmann-La Roche (A.S., P.F., S.B., N.M.), Basel, Switzerland; McGill University (D.L.A., A.B.-O.) and NeuroRx Research (D.L.A.), Montreal, and University of British Columbia, Vancouver (A.T.) - both in Canada; University Vita-Salute San Raffaele, Milan (G.C.); University Hospital of Strasbourg, Clinical Investigation Center (INSERM Unité 1434), Fédération de Médecine Translationnelle de Strasbourg, Strasbourg, France (J.S.); Barts and the London School of Medicine and Dentistry, London (G.G.); Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf (H.-P.H.), and Technical University of Munich and Munich Cluster for Systems Neurology, Munich (B.H.) - both in Germany; Icahn School of Medicine at Mount Sinai, New York (F.L.); University of Miami, Miami (K.W.R.); Medical University of Łódź, Łódź, Poland (K.S.); and McGovern Medical School, University of Texas Health Science Center at Houston, Houston (J.S.W.).

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http://dx.doi.org/10.1056/NEJMoa1606468DOI Listing
January 2017

Improvement in relapse recovery with peginterferon beta-1a in patients with multiple sclerosis.

Mult Scler J Exp Transl Clin 2016 Jan-Dec;2:2055217316676644. Epub 2016 Nov 15.

Department of Neurology, Allegheny General Hospital, Pittsburgh, PA, USA.

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http://dx.doi.org/10.1177/2055217316676644DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5433498PMC
November 2016

Superior MRI outcomes with alemtuzumab compared with subcutaneous interferon β-1a in MS.

Neurology 2016 Oct 2;87(14):1464-1472. Epub 2016 Sep 2.

From NeuroRx Research (D.L.A.) and Department of Neurology and Neurosurgery (D.L.A.), Montréal Neurological Institute, McGill University, Québec, Canada; Department of Biomedical Engineering (E.F.) and Mellen Center (J.A.C.), Cleveland Clinic, OH; Zagreb Medical School and University Hospital Center (V.V.B.), Croatia; Department of Clinical Neurosciences (A.J.C., D.A.S.C.), University of Cambridge, UK; Queen Mary University of London (G.G.), Barts and the London School of Medicine, UK; Department of Neurology and Center for Neuropsychiatry (H.-P.H.), Heinrich-Heine University, Düsseldorf, Germany; Department of Neurology (E.H.), First Medical Faculty, Charles University in Prague, Czech Republic; Department of Neurology (K.W.S.), Medical University of Łódź, Poland; Clinical Centre Kragujevac (M.S.), Clinic of Neurology, Serbia; Brigham and Women's Hospital Center for Neurologic Diseases (H.L.W.), Boston, MA; Sanofi Genzyme (S.L.L., D.H.M., M.A.P.), Cambridge, MA; and Evidence Scientific Solutions (D.R.T.), Horsham, West Sussex, UK. Dr. Panzara is currently with Wave Life Sciences, Cambridge, MA.

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http://dx.doi.org/10.1212/WNL.0000000000003169DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5075976PMC
October 2016

Impaired growth of the cerebellum in pediatric-onset acquired CNS demyelinating disease.

Mult Scler 2016 09 9;22(10):1266-78. Epub 2015 Nov 9.

McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, QC, Canada

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http://dx.doi.org/10.1177/1352458515615224DOI Listing
September 2016

MTR recovery in brain lesions in the BECOME study of glatiramer acetate vs interferon β-1b.

Neurology 2016 Aug 29;87(9):905-11. Epub 2016 Jul 29.

From the McConnell Brain Imaging Centre (R.A.B., S.N., N.S., D.L.A.), Montreal Neurological Institute and Hospital, Canada; Rutgers-New Jersey Medical School (S.C., D.C.), Newark, NJ; and Case Western Reserve University (L.W.), Cleveland, OH.

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http://dx.doi.org/10.1212/WNL.0000000000003043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5035157PMC
August 2016

MRI in the evaluation of pediatric multiple sclerosis.

Neurology 2016 Aug;87(9 Suppl 2):S88-96

From The Children's Hospital of Philadelphia (B.B.) Perelman School of Medicine, University of Pennsylvania; McConnell Imaging Center (D.L.A.), McGill University, Montreal, Quebec, Canada; Mayo Clinic (J.-M.T.), Rochester, MN; Neuroimaging Research Unit (M.A.R., M.F.), Institute of Experimental Neurology, San Raffaele Scientific Institute, "Vita-Salute" San Raffaele University, Milan, Italy; State University of New York at Buffalo (B.W.-G., R.Z.); and Department of Health Sciences (M.P.S.), University of Genoa, Italy.

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http://dx.doi.org/10.1212/WNL.0000000000002787DOI Listing
August 2016

Normalization of white matter intensity on T1-weighted images of patients with acquired central nervous system demyelination.

J Neuroimaging 2015 Mar-Apr;25(2):184-190. Epub 2014 Jun 19.

Montreal Neurological Institute, McGill University, 3801 rue University, Montreal, QC, Canada, H3A 2B4.

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http://dx.doi.org/10.1111/jon.12129DOI Listing
April 2016

Rotation-invariant multi-contrast non-local means for MS lesion segmentation.

Neuroimage Clin 2015 13;8:376-89. Epub 2015 May 13.

Montreal Neurological Institute, McGill University, Canada.

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http://dx.doi.org/10.1016/j.nicl.2015.05.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4474283PMC
April 2016

Contribution of the cerebellum to cognitive performance in children and adolescents with multiple sclerosis.

Mult Scler 2016 Apr 22;22(5):599-607. Epub 2015 Jul 22.

McConnell Brain Imaging Center, Montreal Neurological Institute, McGill University, Canada

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http://dx.doi.org/10.1177/1352458515595132DOI Listing
April 2016

Intracortical inhibition abnormality during the remission phase of multiple sclerosis is related to upper limb dexterity and lesions.

Clin Neurophysiol 2016 Feb 31;127(2):1503-1511. Epub 2015 Aug 31.

Research Institute of the McGill University Health Centre, 2155 Guy Street, 5th Floor, Montreal, Que. H3H 2R9, Canada; Department of Neurology and Neurosurgery, McGill University, 845 Rue Sherbrooke Ouest, Montréal, Que., Canada. Electronic address:

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http://dx.doi.org/10.1016/j.clinph.2015.08.011DOI Listing
February 2016

Adaptive multi-level conditional random fields for detection and segmentation of small enhanced pathology in medical images.

Med Image Anal 2016 Jan 11;27:17-30. Epub 2015 Jul 11.

Centre for Intelligent Machines, McGill University, Montreal, Canada.

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http://dx.doi.org/10.1016/j.media.2015.06.004DOI Listing
January 2016

Non-Local Means Inpainting of MS Lesions in Longitudinal Image Processing.

Front Neurosci 2015 15;9:456. Epub 2015 Dec 15.

McConnell Brain Imaging Center, Montreal Neurological Institute, McGill University Montreal, QC Canada.

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http://dx.doi.org/10.3389/fnins.2015.00456DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4678220PMC
December 2015

Lower physical activity is associated with higher disease burden in pediatric multiple sclerosis.

Neurology 2015 Nov 12;85(19):1663-9. Epub 2015 Aug 12.

From the Division of Neurology (S.A.G., E.A.Y.), Department of Pediatrics, Hospital for Sick Children, University of Toronto, and Program in Neurosciences and Mental Health, SickKids Research Institute, Toronto, Ontario, Canada; Montreal Neurological Institute (B.A.-B., D.F., D.L.C., D.L.A.), McGill University; the School of Rehabilitation Therapy (M.F.), Faculty of Health Sciences, Queen's University, Kingston, Canada; the Division of Neurology (B.L.B.), the Children's Hospital of Philadelphia, PA; and the Department of Kinesiology and Community Health (R.W.M.), University of Illinois at Urbana-Champaign.

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http://www.neurology.org/content/85/19/1663.full.pdf
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http://www.neurology.org/cgi/doi/10.1212/WNL.000000000000193
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http://dx.doi.org/10.1212/WNL.0000000000001939DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4653106PMC
November 2015

Daclizumab HYP versus Interferon Beta-1a in Relapsing Multiple Sclerosis.

N Engl J Med 2015 Oct;373(15):1418-28

From the Neurologic Clinic and Policlinic, the Departments of Medicine, Clinical Research, and Biomedicine and Biomedical Engineering, University Hospital, Basel, Switzerland (L.K.); the Department of Neurology, University of Münster, Münster, Germany (H.W.); the Department of Neurology, Medical University of Lodz, Lodz, Poland (K.S.); NeuroRx Research and Montreal Neurological Institute, McGill University - both in Montreal (D.L.A.); the Department of Neurology, First Faculty of Medicine, Charles University in Prague, Prague, Czech Republic (E.H.); the Department of Neurology and Neurosurgery, Russian National Research Medical University, and Moscow Multiple Sclerosis Center - both in Moscow (A.B.); Cole Neurological Institute, University of Tennessee, Knoxville (M.K.); the Department of Neurology and the Neurovirology Research Laboratory, University of Utah, and the Veterans Affairs Salt Lake City Health Care System - both in Salt Lake City (J.R.); AbbVie Biotherapeutics, Redwood City, CA (S.G.); and Biogen, Cambridge, MA (M.S., K.R., G.O., J.E.).

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http://www.nejm.org/doi/10.1056/NEJMoa1501481
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http://dx.doi.org/10.1056/NEJMoa1501481DOI Listing
October 2015

Diurnal fluctuations in brain volume: Statistical analyses of MRI from large populations.

Neuroimage 2015 Sep 3;118:126-32. Epub 2015 Jun 3.

McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, 3801 University Street, Montreal, Quebec H3A 2B4, Canada; NeuroRx Research, 3575 Park Avenue, Suite #5322, Montreal, Quebec H2X 4B3, Canada.

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http://dx.doi.org/10.1016/j.neuroimage.2015.05.077DOI Listing
September 2015

Imaging of repeated episodes of demyelination and remyelination in multiple sclerosis.

Neuroimage Clin 2014 15;6:20-5. Epub 2014 Aug 15.

McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, 3801 Rue University, Montreal H3A 2B4, Canada.

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http://dx.doi.org/10.1016/j.nicl.2014.06.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4299955PMC
August 2015

Correlation between brain volume change and T2 relaxation time induced by dehydration and rehydration: implications for monitoring atrophy in clinical studies.

Neuroimage Clin 2014 23;6:166-70. Epub 2014 Aug 23.

McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, 3801 University Street, Montreal, Quebec H3A 2B4, Canada.

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http://dx.doi.org/10.1016/j.nicl.2014.08.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4215533PMC
July 2015

Magnetization transfer ratio recovery in new lesions decreases during adolescence in pediatric-onset multiple sclerosis patients.

Neuroimage Clin 2014 10;6:237-42. Epub 2014 Sep 10.

McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital 3801 Rue University, Montreal H3A 2B4, Canada.

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https://linkinghub.elsevier.com/retrieve/pii/S22131582140013
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http://dx.doi.org/10.1016/j.nicl.2014.09.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4215523PMC
July 2015

Jacobian integration method increases the statistical power to measure gray matter atrophy in multiple sclerosis.

Neuroimage Clin 2014 29;4:10-7. Epub 2013 Oct 29.

McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, 3801 University Street, Montreal, Quebec H3A 2B4, Canada.

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http://dx.doi.org/10.1016/j.nicl.2013.10.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3830061PMC
May 2015

Quantitative Measurement of tissue damage and recovery within new T2w lesions in pediatric- and adult-onset multiple sclerosis.

Mult Scler 2015 May 5;21(6):718-25. Epub 2014 Dec 5.

Montreal Neurological Institute, McGill University, Montreal, QC, Canada

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http://dx.doi.org/10.1177/1352458514551594DOI Listing
May 2015

Towards a better understanding of pseudoatrophy in the brain of multiple sclerosis patients.

Mult Scler 2015 May 26;21(6):675-6. Epub 2015 Jan 26.

Montreal Neurological Institute, McGill University, Canada.

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http://dx.doi.org/10.1177/1352458514564494DOI Listing
May 2015

Onset of multiple sclerosis before adulthood leads to failure of age-expected brain growth.

Neurology 2014 Dec 5;83(23):2140-6. Epub 2014 Nov 5.

From the McConnell Brain Imaging Center (B.A.-B., V.F., S.N., D.L.A., D.A., D.F., D.L.C.), Montreal Neurological Institute, McGill University; The Hospital for Sick Children (C.T., J.G.S., B.B.), University of Toronto; York University (C.T.), Toronto, Canada; and Children's Hospital of Philadelphia (B.B.), University of Pennsylvania.

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http://dx.doi.org/10.1212/WNL.0000000000001045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4276405PMC
December 2014

Epitope spreading as an early pathogenic event in pediatric multiple sclerosis.

Neurology 2014 Dec 7;83(24):2219-26. Epub 2014 Nov 7.

From the Center for Neurologic Diseases (F.J.Q., B.P., A.Y., J.K., R.R., M.H., H.L.W.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA; Neuroimmunology Unit (M.N., S.M., A.B.-O.) and the McConnell Brain Imaging Centre (D.F., S.N., D.L.A.), Montreal Neurological Institute and Hospital, McGill University, Montreal; Hospital for Sick Children (J.O., M.M., B.B.) and the Institute of Health Policy, Management, and Evaluation (J.O.), University of Toronto; Experimental Therapeutics Program (T.J., S.R., A.B.-O.), Montreal Neurological Institute and Hospital, McGill University, Montreal, Canada; and The Children's Hospital of Philadelphia (B.B.), PA.

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http://dx.doi.org/10.1212/WNL.0000000000001066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4277672PMC
December 2014

Surface-based analysis reveals regions of reduced cortical magnetization transfer ratio in patients with multiple sclerosis: a proposed method for imaging subpial demyelination.

Hum Brain Mapp 2014 Jul 4;35(7):3402-13. Epub 2013 Dec 4.

McConnell Brain Imaging Centre, Montreal Neurological Institute, Montreal, Quebec, H3A 2B4, Canada.

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http://dx.doi.org/10.1002/hbm.22410DOI Listing
July 2014

Brain volume and fatigue in patients with postpoliomyelitis syndrome.

PM R 2014 Mar 20;6(3):215-20. Epub 2013 Sep 20.

Department of Neurology and Neurosurgery, Montreal Neurological Institute and Hospital, McGill University Health Centre, Montreal, Quebec, Canada(#).

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http://dx.doi.org/10.1016/j.pmrj.2013.09.009DOI Listing
March 2014

Reply: To PMID 24006277.

Ann Neurol 2014 Mar 7;75(3):463-4. Epub 2014 Mar 7.

Biostatistics Unit, Department of Health Sciences, University of Genoa, Genoa, Italy.

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http://dx.doi.org/10.1002/ana.24111DOI Listing
March 2014

Adaptive voxel, texture and temporal conditional random fields for detection of Gad-enhancing multiple sclerosis lesions in brain MRI.

Med Image Comput Comput Assist Interv 2013 ;16(Pt 3):543-50

Centre for Intelligent Machines, McGill University, Canada.

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http://dx.doi.org/10.1007/978-3-642-40760-4_68DOI Listing
February 2014

Treatment effect on brain atrophy correlates with treatment effect on disability in multiple sclerosis.

Ann Neurol 2014 Jan 2;75(1):43-9. Epub 2014 Jan 2.

Biostatistics Unit, Department of Health Sciences, University of Genoa, Genoa, Italy.

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http://dx.doi.org/10.1002/ana.24018DOI Listing
January 2014

Clinical and MRI activity as determinants of sample size for pediatric multiple sclerosis trials.

Neurology 2013 Oct 21;81(14):1215-21. Epub 2013 Aug 21.

From the Pediatric Demyelinating Disease Program (L.H.V.), Program in Neuroscience & Mental Health, The Hospital for Sick Children, University of Toronto, Canada; Biostatistics Unit (A.S., M.P.S.), Department of Health Sciences, University of Genova, Italy; Department of Neurology & Neurosurgery (D.L.A., A.B.-O.), Montreal Neurological Institute and Hospital, McGill University, Montreal; Department of Neurology and Division of Medical Genetics (A.D.S.), University of British Columbia, Vancouver; Departments of Internal Medicine and Community Health Sciences (R.A.M.), Winnipeg Health Sciences Centre, University of Manitoba, Winnipeg, Canada; and Division of Neurology (B.B.), Department of Pediatrics, The Children's Hospital of Philadelphia, University of Pennsylvania.

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http://dx.doi.org/10.1212/WNL.0b013e3182a6cb9bDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3795606PMC
October 2013