Douglas J Perkins

Douglas J Perkins

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Douglas J Perkins

Publications by authors named "Douglas J Perkins"

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Comparison of 71 bipolar disorder pharmacotherapies for kidney disorder risk: The potential hazards of polypharmacy.

J Affect Disord 2019 Jun 8;252:201-211. Epub 2019 Apr 8.

Department of Internal Medicine, Center for Global Health, University of New Mexico Health Sciences Center, Albuquerque, NM, USA; Department of Internal Medicine, Division of Translational Informatics, University of New Mexico Health Sciences Center, Albuquerque, NM, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jad.2019.04.009DOI Listing
June 2019

Evolution and genetic diversity of the gene associated with artemisinin delayed parasite clearance in .

Antimicrob Agents Chemother 2019 May 13. Epub 2019 May 13.

Department of Biology/Institute for Genomics and Evolutionary Medicine (iGEM), Temple University, Philadelphia, Pennsylvania, USA

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http://dx.doi.org/10.1128/AAC.02550-18DOI Listing
May 2019

Comprehensive comparison of monotherapies for psychiatric hospitalization risk in bipolar disorders.

Bipolar Disord 2018 12 19;20(8):761-771. Epub 2018 Jun 19.

Center for Global Health, Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.

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http://dx.doi.org/10.1111/bdi.12665DOI Listing
December 2018

CD4 T-cell expression of IFN-γ and IL-17 in pediatric malarial anemia.

PLoS One 2017 20;12(4):e0175864. Epub 2017 Apr 20.

University of New Mexico Laboratories of Parasitic and Viral Diseases, Centre for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0175864PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5398558PMC
September 2017

Antimalarials: Molecular Drug Targets and Mechanism of Action.

Curr Top Med Chem 2017 ;17(19):2114-2128

Department of Internal Medicine, Center for Global Health, University of New Mexico Health Sciences Center, MSC10-5550, Albuquerque, NM 87131-0001. United States.

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http://dx.doi.org/10.2174/1568026617666170130115323DOI Listing
August 2017

Reduced Parasite Burden in Children with Falciparum Malaria and Bacteremia Coinfections: Role of Mediators of Inflammation.

Mediators Inflamm 2016 22;2016:4286576. Epub 2016 Jun 22.

Center for Global Health, Department of Internal Medicine, Division of Infectious Diseases, School of Medicine, University of New Mexico, Albuquerque, NM 87131, USA; University of New Mexico/KEMRI Laboratories of Parasitic and Viral Diseases, Centre for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya.

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http://dx.doi.org/10.1155/2016/4286576DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4933845PMC
June 2017

Haplotype of non-synonymous mutations within IL-23R is associated with susceptibility to severe malaria anemia in a P. falciparum holoendemic transmission area of Kenya.

BMC Infect Dis 2017 04 20;17(1):291. Epub 2017 Apr 20.

Department of Biomedical Sciences and Technology, School of Public Health and Community Development, Maseno University, Maseno, Kenya.

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http://dx.doi.org/10.1186/s12879-017-2404-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5397818PMC
April 2017

Association between Fcγ receptor IIA, IIIA and IIIB genetic polymorphisms and susceptibility to severe malaria anemia in children in western Kenya.

BMC Infect Dis 2017 04 20;17(1):289. Epub 2017 Apr 20.

Department of Biomedical Sciences and Technology, School of Public Health and Community Development, Maseno University, Maseno, Kenya.

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http://dx.doi.org/10.1186/s12879-017-2390-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5397742PMC
April 2017

Reduced Hsp70 and Glutamine in Pediatric Severe Malaria Anemia: Role of Hemozoin in Suppressing Hsp70 and NF-κB activation.

Mol Med 2016 Oct 30;22:570-584. Epub 2016 Aug 30.

Center for Global Health, Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.

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http://dx.doi.org/10.2119/molmed.2016.00130DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5082292PMC
October 2016

Hypothyroidism risk compared among nine common bipolar disorder therapies in a large US cohort.

Bipolar Disord 2016 05;18(3):247-60

Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.

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http://dx.doi.org/10.1111/bdi.12391DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5089566PMC
May 2016

Cystic fibrosis CFBE41o- cells contain TLR1 SNP I602S and fail to respond to Mycobacterium abscessus.

J Cyst Fibros 2013 Dec 9;12(6):773-9. Epub 2013 Feb 9.

The University of New Mexico School of Medicine, Center for Global Health, Albuquerque, NM 87131, USA.

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http://dx.doi.org/10.1016/j.jcf.2013.01.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4712101PMC
December 2013

Suppressed circulating bicyclo-PGE2 levels and leukocyte COX-2 transcripts in children co-infected with P. falciparum malaria and HIV-1 or bacteremia.

Biochem Biophys Res Commun 2013 Jul 3;436(4):585-90. Epub 2013 Jun 3.

University of New Mexico, Laboratories of Parasitic and Viral Diseases, Centre for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya.

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http://dx.doi.org/10.1016/j.bbrc.2013.05.089DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4703399PMC
July 2013

Connecting network properties of rapidly disseminating epizoonotics.

PLoS One 2012 25;7(6):e39778. Epub 2012 Jun 25.

Center for Global Health, Health Sciences Center, University of New Mexico, Albuquerque, New Mexico, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0039778PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3382573PMC
January 2013

Reduced interferon (IFN)-α conditioned by IFNA2 (-173) and IFNA8 (-884) haplotypes is associated with enhanced susceptibility to severe malarial anemia and longitudinal all-cause mortality.

Hum Genet 2012 Aug 9;131(8):1375-91. Epub 2012 May 9.

Center for Global Health, Department of Internal Medicine, University of New Mexico Health Sciences Center, MSC10-5550, Albuquerque, NM 87131-0001, USA.

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http://dx.doi.org/10.1007/s00439-012-1175-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3665420PMC
August 2012

Relationship between inflammatory mediator patterns and anemia in HIV-1 positive and exposed children with Plasmodium falciparum malaria.

Am J Hematol 2012 Jul 8;87(7):652-8. Epub 2012 May 8.

Center for Global Health, Department of Internal Medicine, University of New Mexico, Albuquerque, NM 87131-0001, USA.

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http://dx.doi.org/10.1002/ajh.23200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4703404PMC
July 2012

Severe malarial anemia: innate immunity and pathogenesis.

Int J Biol Sci 2011 2;7(9):1427-42. Epub 2011 Nov 2.

Center for Global Health, Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque NM, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3221949PMC
http://dx.doi.org/10.7150/ijbs.7.1427DOI Listing
May 2012

Functional promoter haplotypes of interleukin-18 condition susceptibility to severe malarial anemia and childhood mortality.

Infect Immun 2011 Dec 3;79(12):4923-32. Epub 2011 Oct 3.

University of New Mexico/Kenya Medical Research Institute, Laboratories of Parasitic and Viral Diseases, Centre for Global Health Research, Kisumu, Kenya.

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http://dx.doi.org/10.1128/IAI.05601-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3232671PMC
December 2011

Identification of inflammatory biomarkers for pediatric malarial anemia severity using novel statistical methods.

Infect Immun 2011 Nov 22;79(11):4674-80. Epub 2011 Aug 22.

University of New Mexico Laboratories of Parasitic and Viral Diseases, Centre for Global Health Research, Kenya Medical Research Institute, P.O. Box 1578, 40100, Kisumu, Kenya.

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http://dx.doi.org/10.1128/IAI.05161-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3257924PMC
November 2011

Mechanisms of erythropoiesis inhibition by malarial pigment and malaria-induced proinflammatory mediators in an in vitro model.

Am J Hematol 2011 Feb;86(2):155-62

Department of Infectious Diseases and Microbiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pennsylvania, USA.

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http://doi.wiley.com/10.1002/ajh.21933
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http://dx.doi.org/10.1002/ajh.21933DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4703402PMC
February 2011

Clinical predictors of severe malarial anaemia in a holoendemic Plasmodium falciparum transmission area.

Br J Haematol 2010 Jun 16;149(5):711-21. Epub 2010 Apr 16.

Division of Haematology/Oncology, Vascular Medicine Institute, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.

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http://dx.doi.org/10.1111/j.1365-2141.2010.08147.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3095459PMC
June 2010

A novel functional variant in the stem cell growth factor promoter protects against severe malarial anemia.

Infect Immun 2010 Jan 2;78(1):453-60. Epub 2009 Nov 2.

University of New Mexico/KEMRI Laboratories of Parasitic and Viral Diseases, Centre for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya.

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http://dx.doi.org/10.1128/IAI.00895-09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2798205PMC
January 2010

Suppression of a novel hematopoietic mediator in children with severe malarial anemia.

Infect Immun 2009 Sep 15;77(9):3864-71. Epub 2009 Jun 15.

Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, USA.

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http://dx.doi.org/10.1128/IAI.00342-09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2737985PMC
September 2009

Naturally acquired hemozoin by monocytes promotes suppression of RANTES in children with malarial anemia through an IL-10-dependent mechanism.

Microbes Infect 2009 Jul-Aug;11(8-9):811-9. Epub 2009 May 7.

University of New Mexico/Kenya Medical Research Institute, Laboratories of Parasitic and Viral Diseases, Centre for Global Health Research, Kisumu, Kenya.

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http://dx.doi.org/10.1016/j.micinf.2009.04.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2745194PMC
August 2009

MIF (macrophage migration inhibitory factor) promoter polymorphisms and susceptibility to severe malarial anemia.

J Infect Dis 2009 Aug;200(4):629-37

Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

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http://dx.doi.org/10.1086/600894DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3607439PMC
August 2009

Haplotypes of IL-10 promoter variants are associated with susceptibility to severe malarial anemia and functional changes in IL-10 production.

Hum Genet 2008 Dec 30;124(5):515-24. Epub 2008 Oct 30.

Centre for Global Health Research, Kenya Medical Research Institute, University of New Mexico/KEMRI Laboratories of Parasitic and Viral Diseases, Kisumu, Kenya.

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http://dx.doi.org/10.1007/s00439-008-0578-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2723852PMC
December 2008

Increased circulating interleukin (IL)-23 in children with malarial anemia: in vivo and in vitro relationship with co-regulatory cytokines IL-12 and IL-10.

Clin Immunol 2008 Feb 22;126(2):211-21. Epub 2007 Oct 22.

University of Pittsburgh/KEMRI Laboratories of Parasitic and Viral Diseases, Centre for Vector Biology and Control Research, Kenya Medical Research Institute, Kisumu, Kenya.

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http://dx.doi.org/10.1016/j.clim.2007.08.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2257984PMC
February 2008

Higher production of peripheral blood macrophage migration inhibitory factor in healthy children with a history of mild malaria relative to children with a history of severe malaria.

Am J Trop Med Hyg 2007 Jun;76(6):1033-6

Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA.

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http://www.ajtmh.org/content/76/6/1033.full.pdf
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June 2007

Role of monocyte-acquired hemozoin in suppression of macrophage migration inhibitory factor in children with severe malarial anemia.

Infect Immun 2007 Jan 23;75(1):201-10. Epub 2006 Oct 23.

Department of Infectious Diseases & Microbiology, Graduate School of Public Health, University of Pittsburgh, 130 DeSoto Street, 603 Parran Hall, Pittsburgh, PA 15261, USA.

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http://iai.asm.org/cgi/doi/10.1128/IAI.01327-06
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http://dx.doi.org/10.1128/IAI.01327-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1828375PMC
January 2007

Suppression of RANTES in children with Plasmodium falciparum malaria.

Haematologica 2006 Oct;91(10):1396-9

Department of Pathology, School of Health Sciences, Kenyatta University, Nairobi, Kenya.

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October 2006

Acquisition of hemozoin by monocytes down-regulates interleukin-12 p40 (IL-12p40) transcripts and circulating IL-12p70 through an IL-10-dependent mechanism: in vivo and in vitro findings in severe malarial anemia.

Infect Immun 2006 Sep;74(9):5249-60

University of Pittsburgh Graduate School of Public Health, Department of Infectious Diseases and Microbiology, 130 DeSoto Street, 603 Parran Hall, Pittsburgh, PA 15261, USA.

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http://dx.doi.org/10.1128/IAI.00843-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1594872PMC
September 2006

Decreased circulating macrophage migration inhibitory factor (MIF) protein and blood mononuclear cell MIF transcripts in children with Plasmodium falciparum malaria.

Clin Immunol 2006 May 7;119(2):219-25. Epub 2006 Feb 7.

Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, 130 DeSoto Street, 603 Parran Hall, Pittsburgh, PA 15261, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S152166160500420
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http://dx.doi.org/10.1016/j.clim.2005.12.003DOI Listing
May 2006

Suppression of prostaglandin E2 by malaria parasite products and antipyretics promotes overproduction of tumor necrosis factor-alpha: association with the pathogenesis of childhood malarial anemia.

J Infect Dis 2006 May 7;193(10):1384-93. Epub 2006 Apr 7.

Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA, and Albert Schweitzer Hospital, Lambaréné, Gabon.

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http://dx.doi.org/10.1086/503047DOI Listing
May 2006

Association of FCgamma receptor IIA (CD32) polymorphism with malarial anemia and high-density parasitemia in infants and young children.

Am J Trop Med Hyg 2006 Apr;74(4):573-7

University of Pittsburgh/Kenya Medical Research Institute Laboratories of Parasitic and Viral Diseases, Kisumu, Kenya.

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April 2006

Parasitemia, anemia, and malarial anemia in infants and young children in a rural holoendemic Plasmodium falciparum transmission area.

Am J Trop Med Hyg 2006 Mar;74(3):376-85

University of Pittsburgh/KEMRI Laboratories of Parasitic and Viral Diseases, Kenya Medical Research Institute, Center for Vector Biology and Control Research, Kisumu, Kenya.

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March 2006

Stage-specific effects of Plasmodium falciparum-derived hemozoin on blood mononuclear cell TNF-alpha regulation and viral replication.

AIDS 2005 Nov;19(16):1771-80

Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

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November 2005

Reduced peripheral PGE2 biosynthesis in Plasmodium falciparum malaria occurs through hemozoin-induced suppression of blood mononuclear cell cyclooxygenase-2 gene expression via an interleukin-10-independent mechanism.

Mol Med 2004 Jan-Jun;10(1-6):45-54

Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, 130 DeSoto Street, Pittsburgh, PA 15261, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1431354PMC
October 2005

Differential regulation of beta-chemokines in children with Plasmodium falciparum malaria.

Infect Immun 2005 Jul;73(7):4190-7

Department of Infectious Diseases & Microbiology, University of Pittsburgh, 130 DeSoto Street, 603 Parran Hall, Pittsburgh, Pennsylvania 15261, USA.

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http://dx.doi.org/10.1128/IAI.73.7.4190-4197.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1168587PMC
July 2005

Impaired systemic production of prostaglandin E2 in children with cerebral malaria.

J Infect Dis 2005 May 31;191(9):1548-57. Epub 2005 Mar 31.

University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pennsylvania 15261, USA.

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https://academic.oup.com/jid/article-lookup/doi/10.1086/4293
Publisher Site
http://dx.doi.org/10.1086/429332DOI Listing
May 2005

In vivo acquisition of hemozoin by placental blood mononuclear cells suppresses PGE2, TNF-alpha, and IL-10.

Biochem Biophys Res Commun 2003 Nov;311(4):839-46

Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.

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http://dx.doi.org/10.1016/j.bbrc.2003.10.073DOI Listing
November 2003