Douglas J Adams

Douglas J Adams

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Douglas J Adams

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CD55 Regulates Bone Mass in Mice by Modulating RANKL-Mediated Rac Signaling and Osteoclast Function.

J Bone Miner Res 2020 Jan 23;35(1):130-142. Epub 2019 Oct 23.

UCONN Center on Aging, University of Connecticut Health Center, Farmington, CT, USA.

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http://dx.doi.org/10.1002/jbmr.3861DOI Listing
January 2020

Cells from a GDF5 origin produce zonal tendon-to-bone attachments following anterior cruciate ligament reconstruction.

Ann N Y Acad Sci 2020 Jan 9;1460(1):57-67. Epub 2019 Oct 9.

McKay Orthopaedic Research Laboratory, Department of Orthopaedic Surgery, University of Pennsylvania, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1111/nyas.14250DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6992521PMC
January 2020

Responses to spaceflight of mouse mandibular bone and teeth.

Arch Oral Biol 2018 09 7;93:163-176. Epub 2018 Jun 7.

Department of Craniofacial Sciences, School of Dental Medicine, USA. Electronic address:

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http://dx.doi.org/10.1016/j.archoralbio.2018.06.008DOI Listing
September 2018

Screening Gene Knockout Mice for Variation in Bone Mass: Analysis by μCT and Histomorphometry.

Curr Osteoporos Rep 2018 04;16(2):77-94

Center for Musculoskeletal Research, Department of Orthopaedics and Rehabilitation, University of Rochester School of Medicine, Rochester, NY, 14642, USA.

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http://link.springer.com/10.1007/s11914-018-0421-4
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http://dx.doi.org/10.1007/s11914-018-0421-4DOI Listing
April 2018

High-Throughput, Multi-Image Cryohistology of Mineralized Tissues.

J Vis Exp 2016 09 14(115). Epub 2016 Sep 14.

Department of Reconstructive Sciences, University of Connecticut Health Center;

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http://dx.doi.org/10.3791/54468DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5092021PMC
September 2016

Loss of Bone in Sickle Cell Trait and Sickle Cell Disease Female Mice Is Associated With Reduced IGF-1 in Bone and Serum.

Endocrinology 2016 08 12;157(8):3036-46. Epub 2016 May 12.

Departments of Medicine (L.X., B.A., P.T., V.D., M.M.H.) and Orthopedic Surgery (D.J.A.), UConn Health, Farmington, Connecticut 06030-3105; and Connecticut Children's Hospital (W.T.Z.), Hartford, Connecticut 06106-3322.

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http://dx.doi.org/10.1210/en.2015-2001DOI Listing
August 2016

Genetics of aging bone.

Mamm Genome 2016 08 6;27(7-8):367-80. Epub 2016 Jun 6.

Center for Musculoskeletal Research, Department of Orthopaedics and Rehabilitation, School of Medicine and Dentistry, University of Rochester, 601 Elmwood Ave, Box 665, Rochester, NY, 14624, USA.

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http://dx.doi.org/10.1007/s00335-016-9650-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4948189PMC
August 2016

Evaluation of the donor cell contribution in rhBMP-2 mediated bone formation with chitosan thermogels using fluorescent protein reporter mice.

J Biomed Mater Res A 2016 04 13;104(4):928-41. Epub 2016 Jan 13.

Department of Orthopaedic Surgery, UConn Health, Farmington, Connecticut, 06030.

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http://dx.doi.org/10.1002/jbm.a.35634DOI Listing
April 2016

Accelerated fracture healing in transgenic mice overexpressing an anabolic isoform of fibroblast growth factor 2.

J Cell Biochem 2016 Mar;117(3):599-611

Department of Medicine, University of Connecticut School of Medicine, UCONN Health, Farmington, Connecticut, 06030-052.

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http://dx.doi.org/10.1002/jcb.25308DOI Listing
March 2016

Combination therapy with BMP-2 and a systemic RANKL inhibitor enhances bone healing in a mouse critical-sized femoral defect.

Bone 2016 Mar 23;84:93-103. Epub 2015 Dec 23.

Department of Orthopaedic Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bone.2015.12.052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4903101PMC
March 2016

Systemic Administration of Sclerostin Antibody Enhances Bone Morphogenetic Protein-Induced Femoral Defect Repair in a Rat Model.

J Bone Joint Surg Am 2015 Nov;97(22):1852-9

Department of Orthopaedic Surgery, Keck School of Medicine, University of Southern California, 1520 San Pablo Street, Los Angeles, CA 90033.

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http://dx.doi.org/10.2106/JBJS.O.00171DOI Listing
November 2015

Fixation stability dictates the differentiation pathway of periosteal progenitor cells in fracture repair.

J Orthop Res 2015 Jul 13;33(7):948-56. Epub 2015 May 13.

Center for Regenerative Medicine and Skeletal Development, School of Dental Medicine, University of Rochester School of Medicine, Rochester, New York, 14642.

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http://dx.doi.org/10.1002/jor.22816DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4891973PMC
July 2015

Genetic regulation of bone strength: a review of animal model studies.

Bonekey Rep 2015 8;4:714. Epub 2015 Jul 8.

Center for Musculoskeletal Research, Department of Orthopaedics and Rehabilitation, University of Rochester, School of Medicine and Dentistry , Rochester, NY, USA.

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http://dx.doi.org/10.1038/bonekey.2015.83DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4495779PMC
July 2015

Evaluation of rhBMP-2 and bone marrow derived stromal cell mediated bone regeneration using transgenic fluorescent protein reporter mice.

J Biomed Mater Res A 2014 12 3;102(12):4568-80. Epub 2014 Mar 3.

Department of Orthopedic Surgery, University of Connecticut Health Center, Farmington, Connecticut, 06032; Institute for Regenerative Engineering, The Raymond Beverly Sackler Center for Biomedical, Biological, Physical and Engineering Sciences, University of Connecticut Health Center, Farmington, Connecticut, 06032.

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http://dx.doi.org/10.1002/jbm.a.35122DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4894319PMC
December 2014

Notch signaling in osteocytes differentially regulates cancellous and cortical bone remodeling.

J Biol Chem 2013 Aug 24;288(35):25614-25. Epub 2013 Jul 24.

Department of Research, Saint Francis Hospital and Medical Center, Hartford, Connecticut 06105-1299, USA.

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http://dx.doi.org/10.1074/jbc.M113.470492DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757222PMC
August 2013

Optimally porous and biomechanically compatible scaffolds for large-area bone regeneration.

Tissue Eng Part A 2012 Jul 16;18(13-14):1376-88. Epub 2012 Apr 16.

Institute for Regenerative Engineering, University of Connecticut Health Center, 263 Farmington Ave., Farmington, CT 06030, USA.

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http://dx.doi.org/10.1089/ten.TEA.2011.0076DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5802344PMC
July 2012

In vivo fate mapping identifies mesenchymal progenitor cells.

Stem Cells 2012 Feb;30(2):187-96

Department of Physiology and Immunology, School of Medicine, University of Zagreb, Zagreb Croatia.

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http://dx.doi.org/10.1002/stem.780DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3560295PMC
February 2012

Radius fracture repair using volumetrically expanding polyurethane bone cement.

J Hand Surg Am 2011 Aug 29;36(8):1294-302. Epub 2011 Jun 29.

Doctors Research Group, Inc., Southbury, CT 06488, USA.

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http://dx.doi.org/10.1016/j.jhsa.2011.05.031DOI Listing
August 2011

Hyperlipidemia induces resistance to PTH bone anabolism in mice via oxidized lipids.

J Bone Miner Res 2011 Jun;26(6):1197-206

Division of Cardiology, Department of Medicine, University of California, Los Angeles, Los Angeles, CA 90095-1679, USA.

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http://dx.doi.org/10.1002/jbmr.312DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3312754PMC
June 2011

"Same day" ex-vivo regional gene therapy: a novel strategy to enhance bone repair.

Mol Ther 2011 May 22;19(5):960-8. Epub 2011 Feb 22.

New England Musculoskeletal Institute, Department of Orthopedic Surgery, University of Connecticut Health Center, Farmington, Connecticut 06030-5456, USA.

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http://dx.doi.org/10.1038/mt.2011.2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3098640PMC
May 2011

Two imaging techniques for 3D quantification of pre-cementation space for CAD/CAM crowns.

J Dent 2010 Dec 27;38(12):995-1000. Epub 2010 Aug 27.

Department of Reconstructive Sciences, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030-1615, USA.

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http://dx.doi.org/10.1016/j.jdent.2010.08.015DOI Listing
December 2010

Long bone fracture repair in mice harboring GFP reporters for cells within the osteoblastic lineage.

J Orthop Res 2010 Oct;28(10):1338-47

Department of Orthopedic Surgery, New England Musculoskeletal Institute, School of Medicine, University of Connecticut Health Center, Farmington, Connecticut 06032, USA.

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http://doi.wiley.com/10.1002/jor.21105
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http://dx.doi.org/10.1002/jor.21105DOI Listing
October 2010

Col3.6-HSD2 transgenic mice: a glucocorticoid loss-of-function model spanning early and late osteoblast differentiation.

Bone 2010 Sep 9;47(3):573-82. Epub 2010 Jun 9.

Department of Medicine, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030, USA.

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http://dx.doi.org/10.1016/j.bone.2010.06.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2926146PMC
September 2010

Altered metabolism and lipodystrophy in the early B-cell factor 1-deficient mouse.

Endocrinology 2010 Apr 19;151(4):1611-21. Epub 2010 Feb 19.

Department of Orthopaedics and Rehabilitation, Yale University School of Medicine, P.O. Box 208071, TMP 516, New Haven, Connecticut 06520-8071.

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http://dx.doi.org/10.1210/en.2009-0987DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2850234PMC
April 2010

Hyponatremia-induced osteoporosis.

J Bone Miner Res 2010 Mar;25(3):554-63

Division of Endocrinology and Metabolism, Georgetown University, Washington, DC 20007, USA.

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http://dx.doi.org/10.1359/jbmr.090827DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3153395PMC
March 2010

Increased bone volume and correction of HYP mouse hypophosphatemia in the Klotho/HYP mouse.

Endocrinology 2010 Feb 1;151(2):492-501. Epub 2009 Dec 1.

Department of Genetics, Yale University School of Medicine, 333 Cedar Street, SHM I-308, New Haven, Connecticut 06510, USA.

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http://dx.doi.org/10.1210/en.2009-0564DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2817612PMC
February 2010

Neuropeptide Y is expressed by osteocytes and can inhibit osteoblastic activity.

J Cell Biochem 2009 Oct;108(3):621-30

Department of Reconstructive Sciences, University of Connecticut Health Center, Farmington, Connecticut 06032, USA.

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http://dx.doi.org/10.1002/jcb.22294DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2754602PMC
October 2009

Measurement of muscle disease by quantitative second-harmonic generation imaging.

J Biomed Opt 2008 Jul-Aug;13(4):044018

University of Connecticut Health Center, Department of Genetics and Developmental Biology, Farmington, Connecticut 06030, USA.

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http://dx.doi.org/10.1117/1.2967536DOI Listing
January 2009

Use of an alpha-smooth muscle actin GFP reporter to identify an osteoprogenitor population.

Bone 2008 Sep 10;43(3):501-10. Epub 2008 May 10.

Department of Genetics and Developmental Biology, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, Connecticut 06032, USA.

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http://dx.doi.org/10.1016/j.bone.2008.04.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2614133PMC
September 2008

The anabolic response to parathyroid hormone is augmented in Rac2 knockout mice.

Endocrinology 2008 Aug 8;149(8):4009-15. Epub 2008 May 8.

Section of Endocrinology, Yale School of Medicine, New Haven, Connecticut 06520-8020, USA.

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http://dx.doi.org/10.1210/en.2008-0034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2488220PMC
August 2008

Osteopenia in transgenic mice with osteoblast-targeted expression of the inducible cAMP early repressor.

Bone 2008 Jul 29;43(1):101-109. Epub 2008 Mar 29.

Department of Medicine, University of Connecticut Health Center, Farmington, CT 06030, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bone.2008.03.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2474743PMC
July 2008

Leg joint power output during progressive resistance FES-LCE cycling in SCI subjects: developing an index of fatigue.

J Neuroeng Rehabil 2008 Apr 26;5:14. Epub 2008 Apr 26.

Functional Performance Laboratory, Department of Allied Health Sciences, University of Connecticut, Storrs, CT, USA.

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http://dx.doi.org/10.1186/1743-0003-5-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2396645PMC
April 2008

Marfan-like skeletal phenotype in the tight skin (Tsk) mouse.

Calcif Tissue Int 2007 Oct 19;81(4):305-15. Epub 2007 Aug 19.

Department of Genetics and Developmental Biology, University of Connecticut Health Center, Farmington, CT 06030, USA.

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http://link.springer.com/10.1007/s00223-007-9059-4
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http://dx.doi.org/10.1007/s00223-007-9059-4DOI Listing
October 2007

Weaning triggers a decrease in receptor activator of nuclear factor-kappaB ligand expression, widespread osteoclast apoptosis, and rapid recovery of bone mass after lactation in mice.

Endocrinology 2007 Aug 10;148(8):3875-86. Epub 2007 May 10.

Section of Pediatric Endocrinology, Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut 06520-8020, USA.

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https://academic.oup.com/endo/article-lookup/doi/10.1210/en.
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http://dx.doi.org/10.1210/en.2006-1467DOI Listing
August 2007

CREM deficiency in mice alters the response of bone to intermittent parathyroid hormone treatment.

Bone 2007 Apr 1;40(4):1135-43. Epub 2007 Feb 1.

Department of Medicine, MC-1850, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030, USA.

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http://dx.doi.org/10.1016/j.bone.2006.12.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1995436PMC
April 2007

T lymphocyte-deficient mice lose trabecular bone mass with ovariectomy.

J Bone Miner Res 2006 Nov;21(11):1704-12

Division of Endocrinology, Department of Medicine, University of Connecticut Health Center, Farmington, Connecticut 06030-5456, USA.

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http://dx.doi.org/10.1359/jbmr.060726DOI Listing
November 2006

Medial opening wedge tibial osteotomy and the sagittal plane: the effect of increasing tibial slope on tibiofemoral contact pressure.

Am J Sports Med 2006 Sep 24;34(9):1431-41. Epub 2006 Apr 24.

Department of Orthopaedics, Medical Arts and Research Building, University of Connecticut Health Center, Farmington, CT 06030, USA.

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http://journals.sagepub.com/doi/10.1177/0363546506287297
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http://dx.doi.org/10.1177/0363546506287297DOI Listing
September 2006

Transgenic mice with osteoblast-targeted insulin-like growth factor-I show increased bone remodeling.

Bone 2006 Sep 27;39(3):494-504. Epub 2006 Apr 27.

Department of Oral Health and Diagnostic Sciences, University of Connecticut Health Center, Farmington, CT 06030, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S875632820600361
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http://dx.doi.org/10.1016/j.bone.2006.02.068DOI Listing
September 2006

Cyclic loading of Achilles tendon repairs: a comparison of polyester and polyblend suture.

Foot Ankle Int 2006 Jul;27(7):512-8

Orthopedic Associates of Hartford, 85 Seymour Street, Suite 607, Hartford, CT 06106, USA.

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http://journals.sagepub.com/doi/10.1177/107110070602700706
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http://dx.doi.org/10.1177/107110070602700706DOI Listing
July 2006

Postnatal growth and bone mass in mice with IGF-I haploinsufficiency.

Bone 2006 Jun 19;38(6):826-35. Epub 2006 Jan 19.

Department of Medicine, The University of Connecticut Health Center, Farmington, 06030-1850, USA.

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http://dx.doi.org/10.1016/j.bone.2005.11.021DOI Listing
June 2006

Interleukin-7 influences osteoclast function in vivo but is not a critical factor in ovariectomy-induced bone loss.

J Bone Miner Res 2006 May;21(5):695-702

Division of Endocrinology, Department of Medicine, University of Connecticut Health Center, Farmington, 06030, USA.

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http://dx.doi.org/10.1359/jbmr.060117DOI Listing
May 2006

Residual strength of the quadriceps versus patellar tendon after harvesting a central free tendon graft.

Arthroscopy 2006 Jan;22(1):76-9

Department of Orthopaedic Surgery, The University of Connecticut School of Medicine, Farmington, Connecticut, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S074980630501575
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http://dx.doi.org/10.1016/j.arthro.2005.10.015DOI Listing
January 2006

The effect of triceps surae contracture force on plantar foot pressure distribution.

Foot Ankle Int 2006 Jan;27(1):43-52

Department of Orthopaedic Surgery, Medical Arts and Research Bldg., 263 Farmington Ave., Farmington, CT 06034-4037, USA.

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http://dx.doi.org/10.1177/107110070602700108DOI Listing
January 2006

Col1a1 promoter-targeted expression of p20 CCAAT enhancer-binding protein beta (C/EBPbeta), a truncated C/EBPbeta isoform, causes osteopenia in transgenic mice.

J Biol Chem 2005 Mar 14;280(9):8117-24. Epub 2004 Dec 14.

Department of Orthodontics, University of Connecticut Health Center, Farmington, Connecticut 06030, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M410076200
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http://dx.doi.org/10.1074/jbc.M410076200DOI Listing
March 2005

The biomechanical effects of low-dose irradiation on bone-patellar tendon-bone allografts.

Am J Sports Med 2004 Jul-Aug;32(5):1131-5. Epub 2004 May 18.

New England Baptist Hospital Sports Medicine Program, Boston, MA, USA.

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http://dx.doi.org/10.1177/0363546503260060DOI Listing
January 2005

Transgenic expression of 11beta-hydroxysteroid dehydrogenase type 2 in osteoblasts reveals an anabolic role for endogenous glucocorticoids in bone.

Endocrinology 2004 Feb 14;145(2):922-9. Epub 2003 Nov 14.

Department of Medicine, MC-1850, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030, USA.

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http://dx.doi.org/10.1210/en.2003-0655DOI Listing
February 2004

Valgus medial collateral ligament rupture causes concomitant loading and damage of the anterior cruciate ligament.

J Knee Surg 2003 Jul;16(3):148-51

Dept of Orthopedic Surgery, University of Connecticut Health Center, 10 Talcott Notch Rd, MC 4037, Farmington, CT 06034-4037, USA.

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July 2003