Publications by authors named "Douglas Hanahan"

96Publications

Myeloid Cells Orchestrate Systemic Immunosuppression, Impairing the Efficacy of Immunotherapy against HPV Cancers.

Cancer Immunol Res 2020 01 26;8(1):131-145. Epub 2019 Nov 26.

Swiss Institute for Experimental Cancer Research, School of Life Sciences, Swiss Federal Institute of Technology Lausanne (EPFL), Lausanne, Switzerland.

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January 2020

A set of microRNAs coordinately controls tumorigenesis, invasion, and metastasis.

Proc Natl Acad Sci U S A 2019 11 8;116(48):24184-24195. Epub 2019 Nov 8.

Swiss Institute for Experimental Cancer Research, School of Life Sciences, Swiss Federal Institute of Technology Lausanne, 1015 Lausanne, Switzerland;

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November 2019

Synaptic proximity enables NMDAR signalling to promote brain metastasis.

Nature 2019 09 18;573(7775):526-531. Epub 2019 Sep 18.

Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, Swiss Federal Institute of Technology Lausanne (EPFL), Lausanne, Switzerland.

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September 2019

ALK7 Signaling Manifests a Homeostatic Tissue Barrier That Is Abrogated during Tumorigenesis and Metastasis.

Dev Cell 2019 05;49(3):409-424.e6

Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, Swiss Federal Institute of Technology Lausanne (EPFL), Lausanne 1015, Switzerland. Electronic address:

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May 2019

Carboplatin/paclitaxel, E7-vaccination and intravaginal CpG as tri-therapy towards efficient regression of genital HPV16 tumors.

J Immunother Cancer 2019 05 6;7(1):122. Epub 2019 May 6.

Department of Urology, Centre Hospitalier Universitaire Vaudois, Bugnon 48, 1011, Lausanne, Switzerland.

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May 2019

Pan-Cancer Landscape of Aberrant DNA Methylation across Human Tumors.

Cell Rep 2018 10;25(4):1066-1080.e8

Department of Computational Biology, University of Lausanne (UNIL), Lausanne, Switzerland; Swiss Institute of Bioinformatics (SIB), University of Lausanne (UNIL), Lausanne, Switzerland. Electronic address:

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October 2018

GKAP Acts as a Genetic Modulator of NMDAR Signaling to Govern Invasive Tumor Growth.

Cancer Cell 2018 04 29;33(4):736-751.e5. Epub 2018 Mar 29.

Swiss Institute of Cancer Research, School of Life Sciences, Swiss Federal Institute of Technology Lausanne (EPFL), 1015 Lausanne, Switzerland. Electronic address:

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April 2018

A Subset of Cancer-Associated Fibroblasts Determines Therapy Resistance.

Cell 2018 02;172(4):643-644

Laboratory of Translational Oncology, ISREC (Swiss Institute for Experimental Cancer Research), School of Life Sciences, Swiss Federal Institute of Technology Lausanne (EPFL), Lausanne CH-1015, Switzerland.

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February 2018

Swiss Medical Weekly congratulates Jaco van Rheenen, recipient of the Dr Josef Steiner Cancer Research Foundation Award for 2017.

Authors:
Douglas Hanahan

Swiss Med Wkly 2017 8;147:w14542. Epub 2017 Nov 8.

Swiss Institute for Experimental Cancer Research (ISREC), EPFL, Geneva, Switzerland.

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November 2017

Combined antiangiogenic and anti-PD-L1 therapy stimulates tumor immunity through HEV formation.

Sci Transl Med 2017 04;9(385)

Laboratory of Tumor Microenvironment and Therapeutic Resistance, VIB-Center for Cancer Biology, Department of Oncology, Katholieke Universiteit Leuven, 3000 Leuven, Belgium.

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April 2017

Metabolic Symbiosis Enables Adaptive Resistance to Anti-angiogenic Therapy that Is Dependent on mTOR Signaling.

Cell Rep 2016 05 28;15(6):1144-60. Epub 2016 Apr 28.

The Swiss Institute for Experimental Cancer Research (ISREC), EPFL SV ISREC, Station 19, 1015 Lausanne, Switzerland; The Swiss Cancer Center Lausanne (SCCL), Swiss Federal Institute of Technology Lausanne (EPFL), 1015 Lausanne, Switzerland. Electronic address:

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May 2016

Bruton Tyrosine Kinase-Dependent Immune Cell Cross-talk Drives Pancreas Cancer.

Cancer Discov 2016 Mar 29;6(3):270-85. Epub 2015 Dec 29.

Department of Cell, Developmental and Cancer Biology, Oregon Health and Science University, Portland, Oregon. Knight Cancer Institute, Oregon Health and Science University, Portland, Oregon.

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March 2016

Dual Targeting of the Autophagic Regulatory Circuitry in Gliomas with Repurposed Drugs Elicits Cell-Lethal Autophagy and Therapeutic Benefit.

Cancer Cell 2015 Oct 24;28(4):456-471. Epub 2015 Sep 24.

Swiss Institute for Experimental Cancer Research, Swiss Federal Institute of Technology, Lausanne 1015, Switzerland. Electronic address:

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October 2015

Deficiency for the cysteine protease cathepsin L impairs Myc-induced tumorigenesis in a mouse model of pancreatic neuroendocrine cancer.

PLoS One 2015 30;10(4):e0120348. Epub 2015 Apr 30.

Swiss Institute for Experimental Cancer Research (ISREC), Swiss Federal Institute of Technology Lausanne (EPFL), Lausanne, Switzerland; Departments of Pathology and Department of Biochemistry and Biophysics, University of California San Francisco (UCSF), San Francisco, United States of America.

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April 2016

Reply to Colorectal cancer classification based on gene expression is not associated with FOLFIRI response.

Nat Med 2014 Nov;20(11):1231-2

cole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.

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November 2014

Reconciliation of classification systems defining molecular subtypes of colorectal cancer: interrelationships and clinical implications.

Cell Cycle 2014 9;13(3):353-7. Epub 2014 Jan 9.

Laboratory for Experimental Oncology and Radiobiology; Center for Experimental Molecular Medicine; Academic Medical Center (AMC); Amsterdam, The Netherlands.

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January 2015

Rethinking the war on cancer.

Authors:
Douglas Hanahan

Lancet 2014 Feb 16;383(9916):558-63. Epub 2013 Dec 16.

Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences. Swiss Federal Institute of Technology Lausanne (EPFL), CH-1015 Lausanne, Switzerland. Electronic address:

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February 2014

A new twist on radiation oncology: low-dose irradiation elicits immunostimulatory macrophages that unlock barriers to tumor immunotherapy.

Cancer Cell 2013 Nov;24(5):559-61

The Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, Swiss Federal Institute of Technology Lausanne (EPFL), 1015 Lausanne, Switzerland.

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November 2013

Bioavailable copper modulates oxidative phosphorylation and growth of tumors.

Proc Natl Acad Sci U S A 2013 Nov 11;110(48):19507-12. Epub 2013 Nov 11.

Swiss Institute for Experimental Cancer Research and Laboratory for Integrative and Systems Physiology, Interfaculty Institute of Bioengineering, School of Life Sciences, and Biomedical Imaging Center, Institute of Physics of Biological Systems, Swiss Federal Institute of Technology Lausanne, CH-1015 Lausanne, Switzerland.

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November 2013

Identification and characterization of poorly differentiated invasive carcinomas in a mouse model of pancreatic neuroendocrine tumorigenesis.

PLoS One 2013 14;8(5):e64472. Epub 2013 May 14.

Cancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.

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December 2013

Using a preclinical mouse model of high-grade astrocytoma to optimize p53 restoration therapy.

Proc Natl Acad Sci U S A 2013 Apr 29;110(16):E1480-9. Epub 2013 Mar 29.

Department of Pathology, Neurology, Neurological Surgery, and Pediatrics, Sandler Neurosciences Center, and Brain Tumor Research Center, University of California, San Francisco, CA 94158, USA.

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April 2013

Hijacking the neuronal NMDAR signaling circuit to promote tumor growth and invasion.

Cell 2013 Mar;153(1):86-100

Swiss Institute for Experimental Cancer Research, School of Life Science, Swiss Federal Institute of Technology Lausanne (EPFL), Lausanne 1015, Switzerland.

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March 2013

A biocompatible in vivo ligation reaction and its application for noninvasive bioluminescent imaging of protease activity in living mice.

ACS Chem Biol 2013 May 29;8(5):987-99. Epub 2013 Mar 29.

Institute of Chemical Sciences and Engineering, Swiss Federal Institute of Technology of Lausanne, LCBIM, CH-1015 Lausanne, Switzerland.

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May 2013

Accessories to the crime: functions of cells recruited to the tumor microenvironment.

Cancer Cell 2012 Mar;21(3):309-22

The Swiss Institute for Experimental Cancer Research, School of Life Sciences, Swiss Federal Institute of Technology Lausanne, CH-1015 Lausanne, Switzerland.

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March 2012

The biology of personalized cancer medicine: facing individual complexities underlying hallmark capabilities.

Mol Oncol 2012 Apr 4;6(2):111-27. Epub 2012 Feb 4.

The Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, Swiss Federal Institute of Technology Lausanne (EPFL), CH-1015 Lausanne, Switzerland.

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April 2012

Imaging guided trials of the angiogenesis inhibitor sunitinib in mouse models predict efficacy in pancreatic neuroendocrine but not ductal carcinoma.

Proc Natl Acad Sci U S A 2011 Dec 14;108(49):E1275-84. Epub 2011 Nov 14.

Diabetes Center, University of California, San Francisco, CA 94143, USA.

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December 2011

Pericytes promote endothelial cell survival through induction of autocrine VEGF-A signaling and Bcl-w expression.

Blood 2011 Sep 21;118(10):2906-17. Epub 2011 Jul 21.

Department of Medical Biochemistry and Biophysics, Division of Vascular Biology, Karolinska Institutet, Stockholm, Sweden.

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September 2011

Increased vascular delivery and efficacy of chemotherapy after inhibition of platelet-derived growth factor-B.

Am J Pathol 2011 Jun;178(6):2920-30

Cardiovascular Research Institute, Comprehensive Cancer Center, Department of Anatomy, University of California, San Francisco, California, USA.

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June 2011

Counterbalancing angiogenic regulatory factors control the rate of cancer progression and survival in a stage-specific manner.

Proc Natl Acad Sci U S A 2011 Jun 27;108(24):9939-44. Epub 2011 May 27.

Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA.

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June 2011

Brivanib, a dual FGF/VEGF inhibitor, is active both first and second line against mouse pancreatic neuroendocrine tumors developing adaptive/evasive resistance to VEGF inhibition.

Clin Cancer Res 2011 Aug 27;17(16):5299-310. Epub 2011 May 27.

Department of Biochemistry & Biophysics, Comprehensive Cancer Center, and Diabetes Center, The University of California at San Francisco, San Francisco, California, USA.

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August 2011

Endogenous Myc maintains the tumor microenvironment.

Genes Dev 2011 May 8;25(9):907-16. Epub 2011 Apr 8.

Department of Pathology, University of California at San Francisco, San Francisco, California 94143, USA.

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May 2011

Hallmarks of cancer: the next generation.

Cell 2011 Mar;144(5):646-74

The Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, EPFL, Lausanne CH-1015, Switzerland.

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March 2011

Differential contribution to neuroendocrine tumorigenesis of parallel egfr signaling in cancer cells and pericytes.

Genes Cancer 2010 Feb;1(2):125-41

Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA, USA.

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February 2010

Genetic deletion of the desmosomal component desmoplakin promotes tumor microinvasion in a mouse model of pancreatic neuroendocrine carcinogenesis.

PLoS Genet 2010 Sep 16;6(9):e1001120. Epub 2010 Sep 16.

Department of Biochemistry and Biophysics, Helen Diller Family Comprehensive Cancer Center, and Diabetes Center, University of California San Francisco, San Francisco, California, USA.

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September 2010

Polymorphic genetic control of tumor invasion in a mouse model of pancreatic neuroendocrine carcinogenesis.

Proc Natl Acad Sci U S A 2010 Oct 20;107(40):17268-73. Epub 2010 Sep 20.

Department of Biochemistry and Biophysics, Diabetes Center, and Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA 94143, USA.

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October 2010

Loss of p19(Arf) facilitates the angiogenic switch and tumor initiation in a multi-stage cancer model via p53-dependent and independent mechanisms.

PLoS One 2010 Aug 27;5(8):e12454. Epub 2010 Aug 27.

Diabetes Center, University of California San Francisco, San Francisco, California, United States of America.

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August 2010

Enhancing tumor-specific uptake of the anticancer drug cisplatin with a copper chelator.

Cancer Cell 2010 Jun;17(6):574-83

Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94143, USA.

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June 2010

Insulin receptor functionally enhances multistage tumor progression and conveys intrinsic resistance to IGF-1R targeted therapy.

Proc Natl Acad Sci U S A 2010 Jun 10;107(24):10791-8. Epub 2010 May 10.

Department of Biochemistry and Biophysics, Diabetes Center, University of California, San Francisco, CA 94143, USA.

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June 2010

Cancer-Associated Fibroblasts Are Activated in Incipient Neoplasia to Orchestrate Tumor-Promoting Inflammation in an NF-kappaB-Dependent Manner.

Cancer Cell 2010 Feb 4;17(2):135-47. Epub 2010 Feb 4.

Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, 94143, USA.

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February 2010

Tissue-penetrating delivery of compounds and nanoparticles into tumors.

Cancer Cell 2009 Dec;16(6):510-20

Vascular Mapping Center, Burnham Institute for Medical Research at UCSB, Biology II Building, University of California, Santa Barbara, Santa Barbara, CA 93106-9610, USA.

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December 2009

MicroRNA dynamics in the stages of tumorigenesis correlate with hallmark capabilities of cancer.

Genes Dev 2009 Sep;23(18):2152-65

Diabetes Center, University of California at San Francisco, San Francisco, California 94143, USA.

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September 2009

Cancer. Breaching the cancer fortress.

Science 2009 Jun;324(5933):1400-1

Comprehensive Cancer Center, Diabetes Center and Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94143-0534, USA.

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June 2009

Genetic ablation of Bcl-x attenuates invasiveness without affecting apoptosis or tumor growth in a mouse model of pancreatic neuroendocrine cancer.

PLoS One 2009 11;4(2):e4455. Epub 2009 Feb 11.

Diabetes and Hellen Diller Family Comprehensive Cancer Centers, Department of Biochemistry & Biophysics, University of California San Francisco, San Francisco, California, United States of America.

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April 2009

Modes of resistance to anti-angiogenic therapy.

Nat Rev Cancer 2008 Aug;8(8):592-603

University of California, San Francisco, Department of Neurological Surgery, Brain Tumour Research Center, San Francisco, California 94143, USA.

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August 2008

Plasticity in tumor-promoting inflammation: impairment of macrophage recruitment evokes a compensatory neutrophil response.

Neoplasia 2008 Apr;10(4):329-40

Department of Biochemistry and Biophysics, Comprehensive Cancer Center, University of California - San Francisco, San Francisco, CA 94143, USA.

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April 2008

Retrospective: Judah Folkman (1933-2008).

Science 2008 Feb;319(5866):1055

Department of Biochemistry and Biophysics, University of California-San Francisco, San Francisco, CA 94143, USA.

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February 2008

Functions of paracrine PDGF signaling in the proangiogenic tumor stroma revealed by pharmacological targeting.

PLoS Med 2008 Jan;5(1):e19

Department of Biochemistry and Biophysics, Diabetes Center and Comprehensive Cancer Center, University of California San Francisco, San Francisco, California, United States ofAmerica.

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January 2008

Assessing tumor progression factors by somatic gene transfer into a mouse model: Bcl-xL promotes islet tumor cell invasion.

PLoS Biol 2007 Oct;5(10):e276

Program in Cancer Biology and Genetics, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.

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October 2007

The origins of oncomice: a history of the first transgenic mice genetically engineered to develop cancer.

Genes Dev 2007 Sep;21(18):2258-70

Department of Biochemistry and Biophysics, Diabetes Center, and Comprehensive Cancer Center, University of California at San Francisco, San Francisco, CA 94143, USA.

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September 2007

Infiltrating neutrophils mediate the initial angiogenic switch in a mouse model of multistage carcinogenesis.

Proc Natl Acad Sci U S A 2006 Aug 4;103(33):12493-8. Epub 2006 Aug 4.

Diabetes and Comprehensive Cancer Centers, University of California, San Francisco, CA 94143, USA.

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August 2006

Lymphatic zip codes in premalignant lesions and tumors.

Cancer Res 2006 Jun;66(11):5696-706

Cancer Research Center and Program in Molecular Pathology, Burnham Institute for Medical Research, La Jolla, California, USA.

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June 2006

Distinct roles for cysteine cathepsin genes in multistage tumorigenesis.

Genes Dev 2006 Mar 15;20(5):543-56. Epub 2006 Feb 15.

Cancer Biology and Genetics Program, Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA.

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March 2006

Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors.

Cancer Cell 2005 Oct;8(4):299-309

Department of Biochemistry and Biophysics, Comprehensive Cancer Center, and Diabetes Center, University of California, San Francisco, San Francisco, California 94143, USA.

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October 2005

Incomplete inhibition of the Rb tumor suppressor pathway in the context of inactivated p53 is sufficient for pancreatic islet tumorigenesis.

Oncogene 2005 Oct;24(44):6597-604

Department of Biochemistry and Biophysics, Diabetes Center and Comprehensive Cancer Center, University of California-San Francisco, 94143, USA.

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October 2005

A functional heparan sulfate mimetic implicates both heparanase and heparan sulfate in tumor angiogenesis and invasion in a mouse model of multistage cancer.

Oncogene 2005 Jun;24(25):4037-51

Department of Biochemistry and Biophysics, Diabetes and Comprehensive Cancer Centers, University of California at San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143-0534, USA.

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June 2005

CD4+ T cell-mediated antigen-specific immunotherapy in a mouse model of cervical cancer.

Cancer Res 2005 Mar;65(5):2018-25

Department of Biochemistry, Diabetes Center and Comprehensive Cancer Center, University of California at San Francisco, San Francisco, California 94143-0534, USA.

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March 2005

A multitargeted, metronomic, and maximum-tolerated dose "chemo-switch" regimen is antiangiogenic, producing objective responses and survival benefit in a mouse model of cancer.

J Clin Oncol 2005 Feb 22;23(5):939-52. Epub 2004 Nov 22.

Department of Biochemistry and Biophysics, Diabetes and Comprehensive Cancer Centers, University of California San Francisco, 513 Parnassas Avenue, San Francisco, CA 94143, USA.

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February 2005

Multiple roles for cysteine cathepsins in cancer.

Cell Cycle 2004 Dec 6;3(12):1516-619. Epub 2004 Dec 6.

Department of Biochemistry and Biophysics, Diabetes and Comprehensive Cancer Centers, University of California at San Francisco, San Francisco, California, USA.

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December 2004

Absence of telomerase and shortened telomeres have minimal effects on skin and pancreatic carcinogenesis elicited by viral oncogenes.

Cancer Cell 2004 Oct;6(4):373-85

Department of Biochemistry and Biophysics, Diabetes Center, and Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94143, USA.

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October 2004

Direct test of potential roles of EIIIA and EIIIB alternatively spliced segments of fibronectin in physiological and tumor angiogenesis.

Mol Cell Biol 2004 Oct;24(19):8662-70

Howard Hughes Medical Institute, Center for Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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October 2004

An amino-bisphosphonate targets MMP-9-expressing macrophages and angiogenesis to impair cervical carcinogenesis.

J Clin Invest 2004 Sep;114(5):623-33

Department of Biochemistry and Biophysics, Diabetes Center, and Comprehensive Cancer Center, University of California, San Francisco, San Francisco, California, USA.

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September 2004

Cathepsin cysteine proteases are effectors of invasive growth and angiogenesis during multistage tumorigenesis.

Cancer Cell 2004 May;5(5):443-53

Department of Biochemistry and Biophysics, Diabetes and Comprehensive Cancer Centers, University of California at San Francisco, 94143, USA.

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May 2004

Oncogene expression and genetic background influence the frequency of DNA copy number abnormalities in mouse pancreatic islet cell carcinomas.

Cancer Res 2004 Apr;64(7):2406-10

Department of Biochemistry, University of California at San Francisco Diabetes and Comprehensive Cancer Center, University of California at San Francisco, San Francisco, California 94143, USA.

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April 2004

Stage-specific vascular markers revealed by phage display in a mouse model of pancreatic islet tumorigenesis.

Cancer Cell 2003 Nov;4(5):393-403

Department of Biochemistry and Biophysics, Diabetes and Comprehensive Cancer Centers, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA.

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November 2003

Progressive vascular changes in a transgenic mouse model of squamous cell carcinoma.

Cancer Cell 2003 Nov;4(5):383-91

Cancer Research Center, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.

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November 2003

Fourteenth Annual Pezcoller Symposium: the novel dichotomy of immune interactions with tumors.

Cancer Res 2003 Jun;63(11):3005-8

University of California at San Francisco, San Francisco, California 94143, USA.

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June 2003

Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors.

J Clin Invest 2003 May;111(9):1287-95

Department of Neurological Surgery, University of California, San Francisco Comprehensive Cancer Center, San Francisco, San Francisco, California 94115, USA.

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May 2003

Immune enhancement of skin carcinogenesis by CD4+ T cells.

J Exp Med 2003 Apr 14;197(8):1017-28. Epub 2003 Apr 14.

Department of Biochemistry and Biophysics, Diabetes and Comprehensive Cancer Centers, University of California at San Francisco, 94143, USA.

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April 2003

VEGF-A has a critical, nonredundant role in angiogenic switching and pancreatic beta cell carcinogenesis.

Cancer Cell 2002 Mar;1(2):193-202

Department of Biochemistry & Biophysics, Diabetes and Comprehensive Cancer Centers, University of California at San Francisco, San Francisco, CA 94143, USA.

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March 2002

Elevated levels of IGF-1 receptor convey invasive and metastatic capability in a mouse model of pancreatic islet tumorigenesis.

Cancer Cell 2002 May;1(4):339-53

Department of Biochemistry & Biophysics and the UCSF Diabetes and Comprehensive Cancer Centers, University of California, San Francisco, 94143, USA.

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May 2002

Antitumor effects in mice of low-dose (metronomic) cyclophosphamide administered continuously through the drinking water.

Cancer Res 2002 May;62(10):2731-5

Departments of Medical Biophysics, Sunnybrook and Women's College Health Sciences Centre, University of Toronto, 2075 Bayview Avenue, Toronto, Ontario, M4N 3M5 Canada.

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May 2002

Sub-lethal radiation enhances anti-tumor immunotherapy in a transgenic mouse model of pancreatic cancer.

BMC Cancer 2002 May 3;2:11. Epub 2002 May 3.

Department of Biochemistry, Diabetes and Comprehensive Cancer Centers, University of California at San Francisco, San Francisco, CA 94143-0534, USA.

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May 2002