Publications by authors named "Douglas B Kell"

100Publications

An untargeted metabolomics strategy to measure differences in metabolite uptake and excretion by mammalian cell lines.

Metabolomics 2020 Oct 7;16(10):107. Epub 2020 Oct 7.

Department of Biochemistry and Systems Biology, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK.

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http://dx.doi.org/10.1007/s11306-020-01725-8DOI Listing
October 2020

A Quantitative Survey of Bacterial Persistence in the Presence of Antibiotics: Towards Antipersister Antimicrobial Discovery.

Antibiotics (Basel) 2020 Aug 13;9(8). Epub 2020 Aug 13.

Department of Biochemistry and Systems Biology, Institute of Systems, Molecular and Integrative Biology, Biosciences Building, University of Liverpool, Crown Street, Liverpool L69 7ZB, UK.

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http://dx.doi.org/10.3390/antibiotics9080508DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7460088PMC
August 2020

Gingipain R1 and Lipopolysaccharide From Have Major Effects on Blood Clot Morphology and Mechanics.

Front Immunol 2020 24;11:1551. Epub 2020 Jul 24.

Department of Physiological Sciences, Faculty of Science, Stellenbosch University, Stellenbosch, South Africa.

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http://dx.doi.org/10.3389/fimmu.2020.01551DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7393971PMC
July 2020

VAE-Sim: A Novel Molecular Similarity Measure Based on a Variational Autoencoder.

Molecules 2020 Jul 29;25(15). Epub 2020 Jul 29.

Department of Biochemistry and Systems Biology, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Crown St, Liverpool L69 7ZB, UK.

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http://dx.doi.org/10.3390/molecules25153446DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7435890PMC
July 2020

The Biology of Lactoferrin, an Iron-Binding Protein That Can Help Defend Against Viruses and Bacteria.

Front Immunol 2020 28;11:1221. Epub 2020 May 28.

Department of Physiological Sciences, Faculty of Science, Stellenbosch University, Stellenbosch, South Africa.

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http://dx.doi.org/10.3389/fimmu.2020.01221DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7271924PMC
July 2020

Is Porphyromonas gingivalis involved in Parkinson's disease?

Eur J Clin Microbiol Infect Dis 2020 Nov 21;39(11):2013-2018. Epub 2020 Jun 21.

Department of Physiological Sciences, Faculty of Science, Stellenbosch University, Stellenbosch, South Africa.

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http://dx.doi.org/10.1007/s10096-020-03944-2DOI Listing
November 2020

Author Correction: Hitchhiking into the cell.

Authors:
Douglas B Kell

Nat Chem Biol 2020 06;16(6):710

Department of Biochemistry, Institute of Integrative Biology, University of Liverpool, Liverpool, UK.

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http://dx.doi.org/10.1038/s41589-020-0540-yDOI Listing
June 2020

The RESOLUTE consortium: unlocking SLC transporters for drug discovery.

Authors:
Giulio Superti-Furga Daniel Lackner Tabea Wiedmer Alvaro Ingles-Prieto Barbara Barbosa Enrico Girardi Ulrich Goldmann Bettina Gürtl Kristaps Klavins Christoph Klimek Sabrina Lindinger Eva Liñeiro-Retes André C Müller Svenja Onstein Gregor Redinger Daniela Reil Vitaly Sedlyarov Gernot Wolf Matthew Crawford Robert Everley David Hepworth Shenping Liu Stephen Noell Mary Piotrowski Robert Stanton Hui Zhang Salvatore Corallino Andrea Faedo Maria Insidioso Giovanna Maresca Loredana Redaelli Francesca Sassone Lia Scarabottolo Michela Stucchi Paola Tarroni Sara Tremolada Helena Batoulis Andreas Becker Eckhard Bender Yung-Ning Chang Alexander Ehrmann Anke Müller-Fahrnow Vera Pütter Diana Zindel Bradford Hamilton Martin Lenter Diana Santacruz Coralie Viollet Charles Whitehurst Kai Johnsson Philipp Leippe Birgit Baumgarten Lena Chang Yvonne Ibig Martin Pfeifer Jürgen Reinhardt Julian Schönbett Paul Selzer Klaus Seuwen Charles Bettembourg Bruno Biton Jörg Czech Hélène de Foucauld Michel Didier Thomas Licher Vincent Mikol Antje Pommereau Frédéric Puech Veeranagouda Yaligara Aled Edwards Brandon J Bongers Laura H Heitman Ad P IJzerman Huub J Sijben Gerard J P van Westen Justine Grixti Douglas B Kell Farah Mughal Neil Swainston Marina Wright-Muelas Tina Bohstedt Nicola Burgess-Brown Liz Carpenter Katharina Dürr Jesper Hansen Andreea Scacioc Giulia Banci Claire Colas Daniela Digles Gerhard Ecker Barbara Füzi Viktoria Gamsjäger Melanie Grandits Riccardo Martini Florentina Troger Patrick Altermatt Cédric Doucerain Franz Dürrenberger Vania Manolova Anna-Lena Steck Hanna Sundström Maria Wilhelm Claire M Steppan

Nat Rev Drug Discov 2020 07;19(7):429-430

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http://dx.doi.org/10.1038/d41573-020-00056-6DOI Listing
July 2020

Hitchhiking into the cell.

Authors:
Douglas B Kell

Nat Chem Biol 2020 04;16(4):367-368

Department of Biochemistry, Institute of Integrative Biology, University of Liverpool, Liverpool, UK.

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http://dx.doi.org/10.1038/s41589-020-0489-xDOI Listing
April 2020

The biology of ergothioneine, an antioxidant nutraceutical.

Nutr Res Rev 2020 Feb 13:1-28. Epub 2020 Feb 13.

The Novo Nordisk Foundation Center for Biosustainability, Building 220, Chemitorvet 200, Technical University of Denmark, 2800Kongens Lyngby, Denmark.

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http://dx.doi.org/10.1017/S0954422419000301DOI Listing
February 2020

L-(+)-Ergothioneine Significantly Improves the Clinical Characteristics of Preeclampsia in the Reduced Uterine Perfusion Pressure Rat Model.

Hypertension 2020 02 23;75(2):561-568. Epub 2019 Dec 23.

From the Irish Centre for Fetal and Neonatal Translational Research, Cork University Maternity Hospital, Ireland (R.D.W., F.P.M., S.M., C.M.).

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.119.13929DOI Listing
February 2020

A Possible Role of Amyloidogenic Blood Clotting in the Evolving Haemodynamics of Female Migraine-With-Aura: Results From a Pilot Study.

Front Neurol 2019 26;10:1262. Epub 2019 Nov 26.

Department of Physiological Sciences, Faculty of Science, Stellenbosch University, Stellenbosch, South Africa.

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http://dx.doi.org/10.3389/fneur.2019.01262DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6887655PMC
November 2019

The role and robustness of the Gini coefficient as an unbiased tool for the selection of Gini genes for normalising expression profiling data.

Sci Rep 2019 11 29;9(1):17960. Epub 2019 Nov 29.

Department of Biochemistry, Institute of Integrative Biology, Faculty of Health and Life Sciences, University of Liverpool, Crown Street, Liverpool, L69 7ZB, UK.

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http://dx.doi.org/10.1038/s41598-019-54288-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6884504PMC
November 2019

Engineering the Yeast for the Production of L-(+)-Ergothioneine.

Front Bioeng Biotechnol 2019 11;7:262. Epub 2019 Oct 11.

The Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kongens Lyngby, Denmark.

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http://dx.doi.org/10.3389/fbioe.2019.00262DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6797849PMC
October 2019

A top priority in pre-eclampsia research: development of a reliable and inexpensive urinary screening test.

Lancet Glob Health 2019 10;7(10):e1312-e1313

Service de Réanimation néonatale, Centre d'Etudes Périnatales Océan Indien, Centre Hospitalier Universitaire Sud-Réunion, Saint-Pierre, France.

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http://dx.doi.org/10.1016/S2214-109X(19)30319-5DOI Listing
October 2019

Parkinson's Disease: A Systemic Inflammatory Disease Accompanied by Bacterial Inflammagens.

Front Aging Neurosci 2019 27;11:210. Epub 2019 Aug 27.

Department of Physiological Sciences, Faculty of Science, Stellenbosch University, Stellenbosch, South Africa.

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http://dx.doi.org/10.3389/fnagi.2019.00210DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6718721PMC
August 2019

Generation of a Small Library of Natural Products Designed to Cover Chemical Space Inexpensively.

Pharm Front 2019 9;1(1):e190005. Epub 2019 Aug 9.

School of Chemistry, The University of Manchester, 131 Princess St, Manchester M1 7DN, UK.

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http://dx.doi.org/10.20900/pf20190005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6726486PMC
August 2019

Involvement of multiple influx and efflux transporters in the accumulation of cationic fluorescent dyes by Escherichia coli.

BMC Microbiol 2019 08 22;19(1):195. Epub 2019 Aug 22.

Department of Chemistry, The University of Manchester, 131 Princess St, Manchester, M1 7DN, UK.

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http://dx.doi.org/10.1186/s12866-019-1561-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6704527PMC
August 2019

GeneORator: An Effective Strategy for Navigating Protein Sequence Space More Efficiently through Boolean OR-Type DNA Libraries.

ACS Synth Biol 2019 06 7;8(6):1371-1378. Epub 2019 Jun 7.

Manchester Centre for Synthetic Biology of Fine and Speciality Chemicals (SYNBIOCHEM), Manchester Institute of Biotechnology , The University of Manchester , Manchester M1 7DN , United Kingdom.

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http://dx.doi.org/10.1021/acssynbio.9b00063DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7007284PMC
June 2019

Serum amyloid A binds to fibrin(ogen), promoting fibrin amyloid formation.

Sci Rep 2019 02 28;9(1):3102. Epub 2019 Feb 28.

Department of Physiological Sciences, Stellenbosch University, Stellenbosch Private Bag X1 Matieland, 7602, Stellenbosch, South Africa.

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http://dx.doi.org/10.1038/s41598-019-39056-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6395759PMC
February 2019

Bacterial Dysbiosis and Translocation in Psoriasis Vulgaris.

Front Cell Infect Microbiol 2019 4;9. Epub 2019 Feb 4.

Department of Physiological Sciences, Stellenbosch University, Stellenbosch, South Africa.

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https://www.frontiersin.org/article/10.3389/fcimb.2019.00007
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http://dx.doi.org/10.3389/fcimb.2019.00007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369634PMC
December 2019

Very rapid flow cytometric assessment of antimicrobial susceptibility during the apparent lag phase of microbial (re)growth.

Microbiology (Reading) 2019 04 11;165(4):439-454. Epub 2019 Feb 11.

2​Manchester Institute of Biotechnology, The University of Manchester, 131 Princess St, Manchester M1 7DN, UK.

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http://dx.doi.org/10.1099/mic.0.000777DOI Listing
April 2019

Iron Dysregulation and Dormant Microbes as Causative Agents for Impaired Blood Rheology and Pathological Clotting in Alzheimer's Type Dementia.

Front Neurosci 2018 16;12:851. Epub 2018 Nov 16.

Department of Physiological Sciences, Stellenbosch University, Stellenbosch, South Africa.

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http://dx.doi.org/10.3389/fnins.2018.00851DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6251002PMC
November 2018

Ultra-high throughput functional enrichment of large monoamine oxidase (MAO-N) libraries by fluorescence activated cell sorting.

Analyst 2018 Sep;143(19):4747-4755

School of Chemistry, The University of Manchester, 131 Princess St, Manchester M1 7DN, UK.

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http://dx.doi.org/10.1039/c8an00851eDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156879PMC
September 2018

The Potential of LPS-Binding Protein to Reverse Amyloid Formation in Plasma Fibrin of Individuals With Alzheimer-Type Dementia.

Front Aging Neurosci 2018 22;10:257. Epub 2018 Aug 22.

Department of Physiological Sciences, Faculty of Science, Stellenbosch University, Stellenbosch, South Africa.

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http://dx.doi.org/10.3389/fnagi.2018.00257DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6113936PMC
August 2018

Fast and Flexible Synthesis of Combinatorial Libraries for Directed Evolution.

Methods Enzymol 2018 24;608:59-79. Epub 2018 May 24.

School of Chemistry, Faculty of Science and Engineering, Manchester Synthetic Biology Research Centre for Fine and Speciality Chemicals (SYNBIOCHEM), Manchester Institute of Biotechnology, University of Manchester, Manchester, United Kingdom. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00766879183014
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http://dx.doi.org/10.1016/bs.mie.2018.04.006DOI Listing
June 2019

PartsGenie: an integrated tool for optimizing and sharing synthetic biology parts.

Bioinformatics 2018 07;34(13):2327-2329

Manchester Centre for Synthetic Biology of Fine and Speciality Chemicals (SYNBIOCHEM), Manchester Institute of Biotechnology, The University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1093/bioinformatics/bty105DOI Listing
July 2018

Energetic evolution of cellular Transportomes.

BMC Genomics 2018 May 30;19(1):418. Epub 2018 May 30.

The Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, 2800, Lyngby, Denmark.

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http://dx.doi.org/10.1186/s12864-018-4816-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5977736PMC
May 2018

Engineering the "Missing Link" in Biosynthetic (-)-Menthol Production: Bacterial Isopulegone Isomerase.

ACS Catal 2018 Mar 24;8(3):2012-2020. Epub 2018 Jan 24.

Manchester Centre for Fine and Speciality Chemicals (SYNBIOCHEM) and School of Chemistry, Manchester Institute of Biotechnology, University of Manchester, Manchester M1 7DN, United Kingdom.

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http://dx.doi.org/10.1021/acscatal.7b04115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5937688PMC
March 2018

No effects without causes: the Iron Dysregulation and Dormant Microbes hypothesis for chronic, inflammatory diseases.

Biol Rev Camb Philos Soc 2018 08 25;93(3):1518-1557. Epub 2018 Mar 25.

Department of Physiological Sciences, Stellenbosch University, Stellenbosch Private Bag X1, Matieland, 7602, South Africa.

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http://dx.doi.org/10.1111/brv.12407DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6055827PMC
August 2018

Lipopolysaccharide-binding protein (LBP) can reverse the amyloid state of fibrin seen or induced in Parkinson's disease.

PLoS One 2018 1;13(3):e0192121. Epub 2018 Mar 1.

Department of Physiological Sciences, Faculty of Science, Stellenbosch University, Stellenbosch, South Africa.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0192121PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5832207PMC
June 2018

Both lipopolysaccharide and lipoteichoic acids potently induce anomalous fibrin amyloid formation: assessment with novel Amytracker™ stains.

J R Soc Interface 2018 02;15(139)

Department of Physiological Sciences, Stellenbosch University, Stellenbosch Private Bag X1, Matieland 7602, South Africa

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http://dx.doi.org/10.1098/rsif.2017.0941DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5832738PMC
February 2018

GeneGini: Assessment via the Gini Coefficient of Reference "Housekeeping" Genes and Diverse Human Transporter Expression Profiles.

Cell Syst 2018 Feb 7;6(2):230-244.e1. Epub 2018 Feb 7.

School of Chemistry, 131, Princess Street, Manchester M1 7DN, UK; The Manchester Institute of Biotechnology, 131, Princess Street, Manchester M1 7DN, UK. Electronic address:

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http://dx.doi.org/10.1016/j.cels.2018.01.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5840522PMC
February 2018

Selenzyme: enzyme selection tool for pathway design.

Bioinformatics 2018 06;34(12):2153-2154

BBSRC/EPSRC Manchester Centre for Synthetic Biology of Fine and Speciality Chemicals (SYNBIOCHEM), Manchester Institute of Biotechnology.

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http://dx.doi.org/10.1093/bioinformatics/bty065DOI Listing
June 2018

Immunological Tolerance, Pregnancy, and Preeclampsia: The Roles of Semen Microbes and the Father.

Front Med (Lausanne) 2017 4;4:239. Epub 2018 Jan 4.

School of Chemistry, The University of Manchester, Manchester, United Kingdom.

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http://dx.doi.org/10.3389/fmed.2017.00239DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5758600PMC
January 2018

The potential therapeutic effects of ergothioneine in pre-eclampsia.

Free Radic Biol Med 2018 03 25;117:145-157. Epub 2017 Dec 25.

Irish Centre for Fetal and Neonatal Translational Research (INFANT), Cork University Maternity Hospital, Cork, Ireland. Electronic address:

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http://dx.doi.org/10.1016/j.freeradbiomed.2017.12.030DOI Listing
March 2018

Analysing and Navigating Natural Products Space for Generating Small, Diverse, But Representative Chemical Libraries.

Biotechnol J 2018 Jan 6;13(1). Epub 2017 Dec 6.

Dr. S. O'Hagan, Prof. D. B. Kell, School of Chemistry, The University of Manchester, 131 Princess St, Manchester M1 7DN, UK.

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http://dx.doi.org/10.1002/biot.201700503DOI Listing
January 2018

Substantial fibrin amyloidogenesis in type 2 diabetes assessed using amyloid-selective fluorescent stains.

Cardiovasc Diabetol 2017 11 2;16(1):141. Epub 2017 Nov 2.

Department of Physiological Sciences, Faculty of Science, Stellenbosch University, Stellenbosch Private Bag X1 Matieland, Stellenbosh, 7602, South Africa.

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http://dx.doi.org/10.1186/s12933-017-0624-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5668975PMC
November 2017

Evolutionary algorithms and synthetic biology for directed evolution: commentary on "on the mapping of genotype to phenotype in evolutionary algorithms" by Peter A. Whigham, Grant Dick, and James Maclaurin.

Authors:
Douglas B Kell

Genet Program Evolvable Mach 2017 29;18(3):373-378. Epub 2017 Mar 29.

School of Chemistry, The University of Manchester, 131, Princess St, Manchester, Lancs, M1 7DN UK.

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http://dx.doi.org/10.1007/s10710-017-9292-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5618731PMC
March 2017

Lipopolysaccharide-binding protein (LBP) reverses the amyloid state of fibrin seen in plasma of type 2 diabetics with cardiovascular co-morbidities.

Sci Rep 2017 08 29;7(1):9680. Epub 2017 Aug 29.

School of Chemistry, The University of Manchester, 131 Princess St, MANCHESTER M1 7DN, Lancs, UK.

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http://dx.doi.org/10.1038/s41598-017-09860-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5574907PMC
August 2017

biochem4j: Integrated and extensible biochemical knowledge through graph databases.

PLoS One 2017 14;12(7):e0179130. Epub 2017 Jul 14.

Manchester Centre for Synthetic Biology of Fine and Specialty Chemicals (SYNBIOCHEM), Manchester Institute of Biotechnology, The University of Manchester, Manchester, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0179130PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5510799PMC
September 2017

Mass spectrometry imaging shows major derangements in neurogranin and in purine metabolism in the triple-knockout 3×Tg Alzheimer mouse model.

Biochim Biophys Acta Proteins Proteom 2017 Jul 11;1865(7):747-754. Epub 2017 Apr 11.

Center for Proteomics and Metabolomics, Leiden University Medical Center, Leiden, The Netherlands; Fondazione Pisana per la Scienza ONLUS, Pisa, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.bbapap.2017.04.002DOI Listing
July 2017

Enhancing Drug Efficacy and Therapeutic Index through Cheminformatics-Based Selection of Small Molecule Binary Weapons That Improve Transporter-Mediated Targeting: A Cytotoxicity System Based on Gemcitabine.

Front Pharmacol 2017 27;8:155. Epub 2017 Mar 27.

Manchester Institute of Biotechnology, University of ManchesterManchester, UK; School of Chemistry, University of ManchesterManchester, UK; Centre for Synthetic Biology of Fine and Speciality Chemicals, University of ManchesterManchester, UK.

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http://dx.doi.org/10.3389/fphar.2017.00155DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5366350PMC
March 2017

Analysis of drug-endogenous human metabolite similarities in terms of their maximum common substructures.

J Cheminform 2017 9;9:18. Epub 2017 Mar 9.

School of Chemistry, The University of Manchester, 131 Princess St, Manchester, M1 7DN UK.

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http://dx.doi.org/10.1186/s13321-017-0198-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5344883PMC
March 2017

A Dormant Microbial Component in the Development of Preeclampsia.

Front Med (Lausanne) 2016 29;3:60. Epub 2016 Nov 29.

The Irish Centre for Fetal and Neonatal Translational Research (INFANT), University College Cork, Cork, Ireland; Department of Obstetrics and Gynecology, University College Cork, Cork, Ireland.

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http://dx.doi.org/10.3389/fmed.2016.00060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5126693PMC
November 2016

Major involvement of bacterial components in rheumatoid arthritis and its accompanying oxidative stress, systemic inflammation and hypercoagulability.

Exp Biol Med (Maywood) 2017 02 26;242(4):355-373. Epub 2016 Nov 26.

2 School of Chemistry, The University of Manchester, Manchester, M13 9PL, UK.

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http://dx.doi.org/10.1177/1535370216681549DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5298544PMC
February 2017

The metabolome 18 years on: a concept comes of age.

Metabolomics 2016 2;12(9):148. Epub 2016 Sep 2.

Cambridge Systems Biology Centre, University of Cambridge, Sanger Building, 80 Tennis Court Road, Cambridge, CB2 1GA UK ; Department of Biochemistry, University of Cambridge, Sanger Building, 80 Tennis Court Road, Cambridge, CB2 1GA UK.

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http://dx.doi.org/10.1007/s11306-016-1108-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5009154PMC
September 2016

SpeedyGenes: Exploiting an Improved Gene Synthesis Method for the Efficient Production of Synthetic Protein Libraries for Directed Evolution.

Methods Mol Biol 2017 ;1472:63-78

Manchester Institute of Biotechnology, The University of Manchester, 131, Princess St, Manchester, M1 7DN, UK.

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http://dx.doi.org/10.1007/978-1-4939-6343-0_5DOI Listing
January 2018

Acute induction of anomalous and amyloidogenic blood clotting by molecular amplification of highly substoichiometric levels of bacterial lipopolysaccharide.

J R Soc Interface 2016 09;13(122)

School of Chemistry, The University of Manchester, 131, Princess Street, Manchester M1 7DN, Lancs, UK The Manchester Institute of Biotechnology, The University of Manchester, 131, Princess Street, Manchester M1 7DN, Lancs, UK Centre for Synthetic Biology of Fine and Speciality Chemicals, The University of Manchester, 131, Princess Street, Manchester M1 7DN, Lancs, UK

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5046953PMC
http://dx.doi.org/10.1098/rsif.2016.0539DOI Listing
September 2016

MetMaxStruct: A Tversky-Similarity-Based Strategy for Analysing the (Sub)Structural Similarities of Drugs and Endogenous Metabolites.

Front Pharmacol 2016 22;7:266. Epub 2016 Aug 22.

School of Chemistry, The University of ManchesterManchester, UK; The Manchester Institute of Biotechnology, The University of ManchesterManchester, UK; Manchester Centre for Synthetic Biology of Fine and Speciality Chemicals, The University of ManchesterManchester, UK.

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http://dx.doi.org/10.3389/fphar.2016.00266DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4992690PMC
September 2016

Proteins behaving badly. Substoichiometric molecular control and amplification of the initiation and nature of amyloid fibril formation: lessons from and for blood clotting.

Prog Biophys Mol Biol 2017 01 21;123:16-41. Epub 2016 Aug 21.

Department of Physiology, Faculty of Health Sciences, University of Pretoria, Arcadia, 0007, South Africa. Electronic address:

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http://dx.doi.org/10.1016/j.pbiomolbio.2016.08.006DOI Listing
January 2017

Recon 2.2: from reconstruction to model of human metabolism.

Metabolomics 2016;12:109. Epub 2016 Jun 7.

Manchester Centre for Synthetic Biology of Fine and Speciality Chemicals (SYNBIOCHEM), Manchester Institute of Biotechnology, The University of Manchester, Manchester, M1 7DN UK ; School of Computer Science, The University of Manchester, Manchester, M13 9PL UK ; Center for Quantitative Medicine, UConn Health, 263 Farmington Avenue, Farmington, CT 06030-6033 USA.

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http://dx.doi.org/10.1007/s11306-016-1051-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4896983PMC
June 2016

SYNBIOCHEM-a SynBio foundry for the biosynthesis and sustainable production of fine and speciality chemicals.

Biochem Soc Trans 2016 06;44(3):675-7

BBSRC/EPSRC Synthetic Biology Research Centre for Fine and Speciality Chemicals (SYNBIOCHEM), Manchester Institute of Biotechnology, The University of Manchester, Manchester, U.K. SYNBIOCHEM Platform/Theme Lead, School of Chemistry, The University of Manchester, Manchester, U.K. SYNBIOCHEM, The University of Manchester, Manchester, U.K.

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http://dx.doi.org/10.1042/BST20160009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4900749PMC
June 2016

Response to 'The Need for Speed', by Matsson et al.

Trends Pharmacol Sci 2016 Apr 26;37(4):245-246. Epub 2016 Feb 26.

Manchester Institute of Biotechnology, The University of Manchester, 131 Princess St, Manchester M1 7DN, UK; Centre for Synthetic Biology of Fine and Speciality Chemicals (SYNBIOCHEM), The University of Manchester, 131, Princess St, Manchester M1 7DN, United Kingdom; School of Chemistry, The University of Manchester, Manchester M13 9PL, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.tips.2016.02.004DOI Listing
April 2016

Implications of endogenous roles of transporters for drug discovery: hitchhiking and metabolite-likeness.

Authors:
Douglas B Kell

Nat Rev Drug Discov 2016 Feb;15(2):143

School of Chemistry, The Manchester Institute of Biotechnology, and the Centre for Synthetic Biology of Fine and Speciality Chemicals (SYNBIOCHEM), The University of Manchester, 131 Princess Street, Manchester M1 7DN, UK.

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http://dx.doi.org/10.1038/nrd.2015.44DOI Listing
February 2016

The apparent permeabilities of Caco-2 cells to marketed drugs: magnitude, and independence from both biophysical properties and endogenite similarities.

PeerJ 2015 17;3:e1405. Epub 2015 Nov 17.

School of Chemistry & The Manchester Institute of Biotechnology and Centre for Synthetic Biology of Fine and Speciality Chemicals (SYNBIOCHEM), The University of Manchester , Manchester, Lancs , United Kingdom.

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http://dx.doi.org/10.7717/peerj.1405DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4655101PMC
November 2015

Fitting Transporter Activities to Cellular Drug Concentrations and Fluxes: Why the Bumblebee Can Fly.

Trends Pharmacol Sci 2015 Nov 1;36(11):710-723. Epub 2015 Nov 1.

Manchester Institute of Biotechnology, The University of Manchester, 131 Princess St, Manchester M1 7DN, UK; Centre for Synthetic Biology of Fine and Speciality Chemicals (SYNBIOCHEM), The University of Manchester, 131, Princess St, Manchester M1 7DN, United Kingdom; School of Chemistry, The University of Manchester, Manchester M13 9PL, United Kingdom. Electronic address:

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http://www.cell.com/trends/pharmacological-sciences/pdf/S016
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http://linkinghub.elsevier.com/retrieve/pii/S016561471500156
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http://dx.doi.org/10.1016/j.tips.2015.07.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4642801PMC
November 2015

On the translocation of bacteria and their lipopolysaccharides between blood and peripheral locations in chronic, inflammatory diseases: the central roles of LPS and LPS-induced cell death.

Integr Biol (Camb) 2015 Nov;7(11):1339-77

Department of Physiology, Faculty of Health Sciences, University of Pretoria, Arcadia 0007, South Africa.

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http://dx.doi.org/10.1039/c5ib00158gDOI Listing
November 2015

Understanding the foundations of the structural similarities between marketed drugs and endogenous human metabolites.

Front Pharmacol 2015 13;6:105. Epub 2015 May 13.

School of Chemistry, The University of Manchester Manchester, UK ; The Manchester Institute of Biotechnology, The University of Manchester Manchester, UK.

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http://dx.doi.org/10.3389/fphar.2015.00105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4429554PMC
June 2015

The dormant blood microbiome in chronic, inflammatory diseases.

FEMS Microbiol Rev 2015 Jul 3;39(4):567-91. Epub 2015 May 3.

Department of Physiology, Faculty of Health Sciences, University of Pretoria, Arcadia 0007, South Africa.

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http://dx.doi.org/10.1093/femsre/fuv013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4487407PMC
July 2015

A 'rule of 0.5' for the metabolite-likeness of approved pharmaceutical drugs.

Metabolomics 2015;11(2):323-339. Epub 2014 Sep 19.

School of Chemistry, The University of Manchester, 131 Princess St, Manchester, M1 7DN UK ; The Manchester Institute of Biotechnology, The University of Manchester, 131 Princess St, Manchester, M1 7DN UK.

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http://dx.doi.org/10.1007/s11306-014-0733-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4342520PMC
September 2014

Membrane transporter engineering in industrial biotechnology and whole cell biocatalysis.

Trends Biotechnol 2015 Apr 3;33(4):237-46. Epub 2015 Mar 3.

Cambridge Systems Biology Centre and Department of Biochemistry, University of Cambridge, Sanger Building, 80 Tennis Court Road, Cambridge CB2 1GA, UK.

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http://dx.doi.org/10.1016/j.tibtech.2015.02.001DOI Listing
April 2015

The virtue of innovation: innovation through the lenses of biological evolution.

J R Soc Interface 2015 Feb;12(103)

Life Sciences Open Innovation, Procter and Gamble, Procter and Gamble Technical Centres Limited, Whitehall Lane, Egham TW20 9NW, UK.

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http://rsif.royalsocietypublishing.org/cgi/doi/10.1098/rsif.
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http://dx.doi.org/10.1098/rsif.2014.1183DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4305420PMC
February 2015

Synthetic biology for the directed evolution of protein biocatalysts: navigating sequence space intelligently.

Chem Soc Rev 2015 Mar;44(5):1172-239

Manchester Institute of Biotechnology, The University of Manchester, 131, Princess St, Manchester M1 7DN, UK.

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http://xlink.rsc.org/?DOI=C4CS00351A
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http://dx.doi.org/10.1039/c4cs00351aDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4349129PMC
March 2015

What would be the observable consequences if phospholipid bilayer diffusion of drugs into cells is negligible?

Authors:
Douglas B Kell

Trends Pharmacol Sci 2015 Jan 10;36(1):15-21. Epub 2014 Nov 10.

School of Chemistry and Manchester Institute of Biotechnology, The University of Manchester, 131 Princess Street, Manchester M1 7DN, UK. Electronic address:

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http://dx.doi.org/10.1016/j.tips.2014.10.005DOI Listing
January 2015

Eryptosis as a marker of Parkinson's disease.

Aging (Albany NY) 2014 Oct;6(10):788-819

School of Chemistry and The Manchester Institute of Biotechnology, The University of Manchester, Manchester M1 7DN, Lancs, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4247384PMC
http://dx.doi.org/10.18632/aging.100695DOI Listing
October 2014

How drugs get into cells: tested and testable predictions to help discriminate between transporter-mediated uptake and lipoidal bilayer diffusion.

Front Pharmacol 2014 31;5:231. Epub 2014 Oct 31.

Department of Biochemistry, University of Cambridge Cambridge, UK ; Cambridge Systems Biology Centre, University of Cambridge Cambridge, UK.

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http://dx.doi.org/10.3389/fphar.2014.00231DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4215795PMC
November 2014

Corrigendum to "Metabolomics and systems pharmacology: why and how to model the human metabolic network for drug discovery" [Drug Discov. Today 19 (2014), 171-182.

Drug Discov Today 2014 Nov 31;19(11):1828. Epub 2014 Mar 31.

School of Chemistry and Manchester Institute of Biotechnology, The University of Manchester, 131 Princess Street, Manchester M1 7DN, UK.

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http://dx.doi.org/10.1016/j.drudis.2014.03.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5617745PMC
November 2014

The simultaneous occurrence of both hypercoagulability and hypofibrinolysis in blood and serum during systemic inflammation, and the roles of iron and fibrin(ogen).

Integr Biol (Camb) 2015 Jan;7(1):24-52

School of Chemistry and The Manchester Institute of Biotechnology, The University of Manchester, 131, Princess St, Manchester M1 7DN, Lancs, UK.

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http://dx.doi.org/10.1039/c4ib00173gDOI Listing
January 2015

Evidence that multiple defects in lipid regulation occur before hyperglycemia during the prodrome of type-2 diabetes.

PLoS One 2014 3;9(9):e103217. Epub 2014 Sep 3.

Institute of Cardiovascular Sciences, Core Technology Facility, The University of Manchester, Manchester, United Kingdom; Diabetes & Nutritional Sciences Division, King's College London, London, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0103217PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4153569PMC
May 2015

SpeedyGenes: an improved gene synthesis method for the efficient production of error-corrected, synthetic protein libraries for directed evolution.

Protein Eng Des Sel 2014 Sep 9;27(9):273-80. Epub 2014 Aug 9.

Manchester Institute of Biotechnology, The University of Manchester, Manchester M1 7DN, UK School of Chemistry, The University of Manchester, Manchester M13 9PL, UK

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https://academic.oup.com/peds/article-lookup/doi/10.1093/pro
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http://dx.doi.org/10.1093/protein/gzu029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4140418PMC
September 2014

GeneGenie: optimized oligomer design for directed evolution.

Nucleic Acids Res 2014 Jul 29;42(Web Server issue):W395-400. Epub 2014 Apr 29.

Manchester Institute of Biotechnology, The University of Manchester, Manchester M1 7DN, UK School of Chemistry, The University of Manchester, Manchester M13 9PL, UK.

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http://dx.doi.org/10.1093/nar/gku336DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4086129PMC
July 2014

Diagnostic morphology: biophysical indicators for iron-driven inflammatory diseases.

Integr Biol (Camb) 2014 May;6(5):486-510

Department of Physiology, Faculty of Health Sciences, University of Pretoria, Private Bag x323, Arcadia 0007, South Africa.

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http://dx.doi.org/10.1039/c4ib00025kDOI Listing
May 2014

Serum ferritin is an important inflammatory disease marker, as it is mainly a leakage product from damaged cells.

Metallomics 2014 Apr;6(4):748-73

School of Chemistry and The Manchester Institute of Biotechnology, The University of Manchester, 131, Princess St, Manchester M1 7DN, Lancs, UK.

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http://dx.doi.org/10.1039/c3mt00347gDOI Listing
April 2014

High ferritin levels have major effects on the morphology of erythrocytes in Alzheimer's disease.

Front Aging Neurosci 2013 6;5:88. Epub 2013 Dec 6.

Department of Physiology, Faculty of Health Sciences, University of Pretoria Arcadia, South Africa.

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http://dx.doi.org/10.3389/fnagi.2013.00088DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3853801PMC
December 2013

Yeast cells with impaired drug resistance accumulate glycerol and glucose.

Mol Biosyst 2014 Jan;10(1):93-102

Cambridge Systems Biology Centre & Department of Biochemistry, University of Cambridge, CB2 1GA, Cambridge, UK.

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http://xlink.rsc.org/?DOI=C2MB25512J
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http://dx.doi.org/10.1039/c2mb25512jDOI Listing
January 2014

Metabolomics and systems pharmacology: why and how to model the human metabolic network for drug discovery.

Drug Discov Today 2014 Feb 26;19(2):171-82. Epub 2013 Jul 26.

School of Chemistry and Manchester Institute of Biotechnology, The University of Manchester, 131 Princess Street, Manchester M1 7DN, UK.

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http://dx.doi.org/10.1016/j.drudis.2013.07.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3989035PMC
February 2014

An analysis of a 'community-driven' reconstruction of the human metabolic network.

Metabolomics 2013 Aug 12;9(4):757-764. Epub 2013 Jul 12.

School of Chemistry, The University of Manchester, Oxford Road, Manchester, M13 9PL UK ; Manchester Institute of Biotechnology, The University of Manchester, Princess Street, Manchester, M1 7DN UK.

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http://dx.doi.org/10.1007/s11306-013-0564-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3715687PMC
August 2013

A method for integrating and ranking the evidence for biochemical pathways by mining reactions from text.

Bioinformatics 2013 Jul;29(13):i44-52

The National Centre for Text Mining and School of Computer Science and School of Chemistry and the Manchester Institute of Biotechnology, The University of Manchester, Manchester M1 7DN, UK.

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http://dx.doi.org/10.1093/bioinformatics/btt227DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3694679PMC
July 2013

Finding novel pharmaceuticals in the systems biology era using multiple effective drug targets, phenotypic screening and knowledge of transporters: where drug discovery went wrong and how to fix it.

Authors:
Douglas B Kell

FEBS J 2013 Dec 22;280(23):5957-80. Epub 2013 Apr 22.

School of Chemistry, The University of Manchester, UK; Manchester Institute of Biotechnology, The University of Manchester, UK.

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http://dx.doi.org/10.1111/febs.12268DOI Listing
December 2013

Genetics and iron in the systems biology of Parkinson's disease and some related disorders.

Neurochem Int 2013 Apr 7;62(5):637-52. Epub 2012 Dec 7.

Department of Neurodegeneration, Hertie Institute for Clinical Brain Research, University of Tübingen, Otfried-Müller-Strasse 27, 72076 Tübingen, Germany.

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http://dx.doi.org/10.1016/j.neuint.2012.11.015DOI Listing
April 2013