Douglas B Cines

Douglas B Cines

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Douglas B Cines

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The risk of major bleeding in patients with suspected heparin-induced thrombocytopenia.

Authors:
Allyson M Pishko Daniel S Lefler Phyllis Gimotty Koosha Paydary Sara Fardin Gowthami M Arepally Mark Crowther Lawrence Rice Rolando Vega Douglas B Cines James P Guevara Adam Cuker

J Thromb Haemost 2019 Jul 27. Epub 2019 Jul 27.

Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1111/jth.14587DOI Listing
July 2019

T2 Magnetic Resonance to Monitor Hemostasis.

Authors:
Adam Cuker Joseph E Marturano Maria E Carinato Thomas J Lowery Douglas B Cines

Semin Thromb Hemost 2019 Apr 17;45(3):247-252. Epub 2018 Aug 17.

Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0038-1667114
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http://dx.doi.org/10.1055/s-0038-1667114DOI Listing
April 2019

Human neutrophil peptide-1 inhibits thrombus formation under arterial flow via its terminal free cysteine thiols.

Authors:
Jenny K McDaniel Mohammad S Abdelgawwad Audra Hargett Matthew B Renfrow Khalil Bdeir Wenjing Cao Douglas B Cines X Long Zheng

J Thromb Haemost 2019 Apr 13;17(4):596-606. Epub 2019 Mar 13.

Division of Laboratory Medicine, Department of Pathology, The University of Alabama at Birmingham, Birmingham, AL, USA.

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http://dx.doi.org/10.1111/jth.14407DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443439PMC
April 2019

Release of IL-6 After Stroke Contributes to Impaired Cerebral Autoregulation and Hippocampal Neuronal Necrosis Through NMDA Receptor Activation and Upregulation of ET-1 and JNK.

Authors:
William M Armstead Hugh Hekierski Philip Pastor Serge Yarovoi Abd Al-Roof Higazi Douglas B Cines

Transl Stroke Res 2019 02 23;10(1):104-111. Epub 2018 Feb 23.

Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.

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http://link.springer.com/10.1007/s12975-018-0617-z
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http://dx.doi.org/10.1007/s12975-018-0617-zDOI Listing
February 2019

Blood clot contraction differentially modulates internal and external fibrinolysis.

Authors:
Valerie Tutwiler Alina D Peshkova Giang Le Minh Sergei Zaitsev Rustem I Litvinov Douglas B Cines John W Weisel

J Thromb Haemost 2019 Feb 6;17(2):361-370. Epub 2019 Feb 6.

Department of Cell and Developmental Biology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.

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http://dx.doi.org/10.1111/jth.14370DOI Listing
February 2019

Neutrophil α-defensins promote thrombosis in vivo by altering fibrin formation, structure, and stability.

Authors:
Rami Abu-Fanne Victoria Stepanova Rustem I Litvinov Suhair Abdeen Khalil Bdeir Mohamed Higazi Emad Maraga Chandrasekaran Nagaswami Alexander R Mukhitov John W Weisel Douglas B Cines Abd Al-Roof Higazi

Blood 2019 01 15;133(5):481-493. Epub 2018 Nov 15.

Department of Clinical Biochemistry, Hadassah-Hebrew University, Jerusalem, Israel.

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http://www.bloodjournal.org/lookup/doi/10.1182/blood-2018-07
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http://dx.doi.org/10.1182/blood-2018-07-861237DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356988PMC
January 2019

Polyreactive IgM initiates complement activation by PF4/heparin complexes through the classical pathway.

Authors:
Sanjay Khandelwal Joann Ravi Lubica Rauova Alexandra Johnson Grace M Lee Jennifer B Gilner Sreenivasulu Gunti Abner L Notkins Maragatha Kuchibhatla Michael Frank Mortimer Poncz Douglas B Cines Gowthami M Arepally

Blood 2018 12 11;132(23):2431-2440. Epub 2018 Oct 11.

Division of Hematology, Duke University Medical Center, Durham, NC.

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http://www.bloodjournal.org/lookup/doi/10.1182/blood-2018-03
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http://dx.doi.org/10.1182/blood-2018-03-834598DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284214PMC
December 2018

Prospective comparison of the HEP score and 4Ts score for the diagnosis of heparin-induced thrombocytopenia.

Authors:
Allyson M Pishko Sara Fardin Daniel S Lefler Koosha Paydary Rolando Vega Gowthami M Arepally Mark Crowther Lawrence Rice Douglas B Cines Adam Cuker

Blood Adv 2018 11;2(22):3155-3162

Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.

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http://dx.doi.org/10.1182/bloodadvances.2018023077DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6258908PMC
November 2018

American Society of Hematology 2018 guidelines for management of venous thromboembolism: heparin-induced thrombocytopenia.

Authors:
Adam Cuker Gowthami M Arepally Beng H Chong Douglas B Cines Andreas Greinacher Yves Gruel Lori A Linkins Stephen B Rodner Sixten Selleng Theodore E Warkentin Ashleigh Wex Reem A Mustafa Rebecca L Morgan Nancy Santesso

Blood Adv 2018 11;2(22):3360-3392

Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, ON, Canada; and.

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http://www.bloodadvances.org/lookup/doi/10.1182/bloodadvance
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http://dx.doi.org/10.1182/bloodadvances.2018024489DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6258919PMC
November 2018

Molecular and cellular pathogenesis of heparin-induced thrombocytopenia (HIT).

Authors:
Lubica Rauova Gowthami Arepally Mortimer Poncz Douglas B Cines

Autoimmun Rev 2018 10 10;17(10):1046-1052. Epub 2018 Aug 10.

Department of Pathology and Laboratory Medicine, University of Pennsylvania, Perelman School of Medicine, USA; Department of Medicine, University of Pennsylvania, Perelman School of Medicine, USA. Electronic address:

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http://dx.doi.org/10.1016/j.autrev.2018.05.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6201246PMC
October 2018

Neutrophil accumulation and NET release contribute to thrombosis in HIT.

Authors:
Kandace Gollomp Minna Kim Ian Johnston Vincent Hayes John Welsh Gowthami M Arepally Mark Kahn Michele P Lambert Adam Cuker Douglas B Cines Lubica Rauova M Anna Kowalska Mortimer Poncz

JCI Insight 2018 09 20;3(18). Epub 2018 Sep 20.

Division of Hematology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1172/jci.insight.99445DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6237233PMC
September 2018

Dynamic intercellular redistribution of HIT antigen modulates heparin-induced thrombocytopenia.

Authors:
Jing Dai Daria Madeeva Vincent Hayes Hyun Sook Ahn Valerie Tutwiler Gowthami M Arepally Douglas B Cines Mortimer Poncz Lubica Rauova

Blood 2018 08 18;132(7):727-734. Epub 2018 Jun 18.

Division of Hematology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA.

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http://dx.doi.org/10.1182/blood-2018-02-830737DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6097133PMC
August 2018

Management of antithrombotic therapy in adults with immune thrombocytopenia (ITP): a survey of ITP specialists and general hematologist-oncologists.

Authors:
Allyson M Pishko Mudi Misgav Adam Cuker Douglas B Cines James N George Sara K Vesely Deirdra R Terrell

J Thromb Thrombolysis 2018 Jul;46(1):24-30

Department of Biostatistics and Epidemiology, College of Public Health, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.

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http://dx.doi.org/10.1007/s11239-018-1649-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355248PMC
July 2018

Biocompatible coupling of therapeutic fusion proteins to human erythrocytes.

Authors:
Carlos H Villa Daniel C Pan Ian H Johnston Colin F Greineder Landis R Walsh Elizabeth D Hood Douglas B Cines Mortimer Poncz Don L Siegel Vladimir R Muzykantov

Blood Adv 2018 02;2(3):165-176

Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA; and.

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http://www.bloodadvances.org/lookup/doi/10.1182/bloodadvance
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http://dx.doi.org/10.1182/bloodadvances.2017011734DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5812327PMC
February 2018

tPA variant tPA-A Prevents impairment of cerebral autoregulation and necrosis of hippocampal neurons after stroke by inhibiting upregulation of ET-1.

Authors:
William M Armstead Hugh Hekierski Serge Yarovoi Abd Al-Roof Higazi Douglas B Cines

J Neurosci Res 2018 01 13;96(1):128-137. Epub 2017 Jul 13.

Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, l9l04.

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http://dx.doi.org/10.1002/jnr.24112DOI Listing
January 2018

Targeting plasminogen activator inhibitor-1 in tetracycline-induced pleural injury in rabbits.

Authors:
Galina Florova Ali O Azghani Sophia Karandashova Chris Schaefer Serge V Yarovoi Paul J Declerck Douglas B Cines Steven Idell Andrey A Komissarov

Am J Physiol Lung Cell Mol Physiol 2018 01 31;314(1):L54-L68. Epub 2017 Aug 31.

Texas Lung Injury Institute, The University of Texas Health Science Center at Tyler , Tyler, Texas.

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http://dx.doi.org/10.1152/ajplung.00579.2016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6048456PMC
January 2018

Urokinase-type plasminogen activator (uPA) is critical for progression of tuberous sclerosis complex 2 (TSC2)-deficient tumors.

Authors:
Victoria Stepanova Konstantin V Dergilev Kelci R Holman Yelena V Parfyonova Zoya I Tsokolaeva Mimi Teter Elena N Atochina-Vasserman Alla Volgina Sergei V Zaitsev Shane P Lewis Fedor G Zabozlaev Kseniya Obraztsova Vera P Krymskaya Douglas B Cines

J Biol Chem 2017 12 27;292(50):20528-20543. Epub 2017 Sep 27.

From the Department of Pathology and Laboratory Medicine and.

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http://dx.doi.org/10.1074/jbc.M117.799593DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5733590PMC
December 2017

Thrombocytopenia in pregnancy.

Authors:
Douglas B Cines Lisa D Levine

Hematology Am Soc Hematol Educ Program 2017 12;2017(1):144-151

Maternal and Child Health Research Center, Department of Obstetrics and Gynecology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.

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http://dx.doi.org/10.1182/asheducation-2017.1.144DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6142617PMC
December 2017

Thrombocytopenia in pregnancy.

Authors:
Douglas B Cines Lisa D Levine

Blood 2017 11 21;130(21):2271-2277. Epub 2017 Jun 21.

Maternal and Child Health Research Center, Department of Obstetrics and Gynecology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.

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http://dx.doi.org/10.1182/blood-2017-05-781971DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5701522PMC
November 2017

Safety and efficacy of romiplostim in splenectomized and nonsplenectomized patients with primary immune thrombocytopenia.

Authors:
Douglas B Cines Jeffrey Wasser Francesco Rodeghiero Beng H Chong Michael Steurer Drew Provan Roger Lyons Jaime Garcia-Chavez Nancy Carpenter Xuena Wang Melissa Eisen

Haematologica 2017 08 14;102(8):1342-1351. Epub 2017 Apr 14.

Amgen Inc., Thousand Oaks, CA, USA.

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http://dx.doi.org/10.3324/haematol.2016.161968DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5541869PMC
August 2017

ICAM-1-targeted thrombomodulin mitigates tissue factor-driven inflammatory thrombosis in a human endothelialized microfluidic model.

Authors:
Colin F Greineder Ian H Johnston Carlos H Villa Kandace Gollomp Charles T Esmon Douglas B Cines Mortimer Poncz Vladimir R Muzykantov

Blood Adv 2017 Aug 8;1(18):1452-1465. Epub 2017 Aug 8.

Department of Systems Pharmacology and Translational Therapeutics and.

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http://dx.doi.org/10.1182/bloodadvances.2017007229DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5727853PMC
August 2017

Endothelial antigen assembly leads to thrombotic complications in heparin-induced thrombocytopenia.

Authors:
Vincent Hayes Ian Johnston Gowthami M Arepally Steven E McKenzie Douglas B Cines Lubica Rauova Mortimer Poncz

J Clin Invest 2017 Mar 20;127(3):1090-1098. Epub 2017 Feb 20.

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http://dx.doi.org/10.1172/JCI90958DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5330743PMC
March 2017

Platelet-Specific Chemokines Contribute to the Pathogenesis of Acute Lung Injury.

Authors:
Khalil Bdeir Kandace Gollomp Marta Stasiak Junjie Mei Izabela Papiewska-Pajak Guohua Zhao G Scott Worthen Douglas B Cines Mortimer Poncz M Anna Kowalska

Am J Respir Cell Mol Biol 2017 Feb;56(2):261-270

Divisions of 2 Hematology and.

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http://dx.doi.org/10.1165/rcmb.2015-0245OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5455412PMC
February 2017

Targeting thrombomodulin to circulating red blood cells augments its protective effects in models of endotoxemia and ischemia-reperfusion injury.

Authors:
Ronald Carnemolla Carlos H Villa Colin F Greineder Sergei Zaitsev Kruti R Patel M Anna Kowalska Dmitriy N Atochin Douglas B Cines Don L Siegel Charles T Esmon Vladimir R Muzykantov

FASEB J 2017 02 11;31(2):761-770. Epub 2016 Nov 11.

Department of Pharmacology, The Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; USA;

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http://dx.doi.org/10.1096/fj.201600912RDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5240667PMC
February 2017

Erythrocytes as Carriers for Drug Delivery in Blood Transfusion and Beyond.

Authors:
Carlos H Villa Douglas B Cines Don L Siegel Vladimir Muzykantov

Transfus Med Rev 2017 01 17;31(1):26-35. Epub 2016 Aug 17.

Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.

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http://dx.doi.org/10.1016/j.tmrv.2016.08.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5161683PMC
January 2017

Rapid Evaluation of Platelet Function With T2 Magnetic Resonance.

Authors:
Adam Cuker Holleh Husseinzadeh Tatiana Lebedeva Joseph E Marturano Walter Massefski Thomas J Lowery Michele P Lambert Charles S Abrams John W Weisel Douglas B Cines

Am J Clin Pathol 2016 Dec 27;146(6):681-693. Epub 2016 Dec 27.

From the Departments of Medicine

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https://academic.oup.com/ajcp/article-lookup/doi/10.1093/ajc
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http://dx.doi.org/10.1093/ajcp/aqw189DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5225753PMC
December 2016

Polyphosphate/platelet factor 4 complexes can mediate heparin-independent platelet activation in heparin-induced thrombocytopenia.

Authors:
Douglas B Cines Serge V Yarovoi Sergei V Zaitsev Tatiana Lebedeva Lubica Rauova Mortimer Poncz Gowthami M Arepally Sanjay Khandelwal Victoria Stepanova Ann H Rux Adam Cuker Cecilia Guo Linnette Mae Ocariza Richard J Travers Stephanie A Smith Hugh Kim James H Morrissey Edward M Conway

Blood Adv 2016 Nov 22;1(1):62-74. Epub 2016 Nov 22.

Faculty of Medicine and Centre for Blood Research, University of British Columbia, Vancouver, BC, Canada.

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http://dx.doi.org/10.1182/bloodadvances.2016000877DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5744055PMC
November 2016

The antigenic complex in HIT binds to B cells via complement and complement receptor 2 (CD21).

Authors:
Sanjay Khandelwal Grace M Lee C Garren Hester Mortimer Poncz Steven E McKenzie Bruce S Sachais Lubica Rauova Garnett Kelsoe Douglas B Cines Michael Frank Gowthami M Arepally

Blood 2016 10 13;128(14):1789-1799. Epub 2016 Jul 13.

Division of Hematology, and.

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http://dx.doi.org/10.1182/blood-2016-04-709634DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5054694PMC
October 2016

Role of monocytes and endothelial cells in heparin-induced thrombocytopenia.

Authors:
Daria Madeeva Douglas B Cines Mortimer Poncz Lubica Rauova

Thromb Haemost 2016 Oct 4;116(5):806-812. Epub 2016 Aug 4.

Lubica Rauova, MD, PhD, The Children's Hospital of Philadelphia, 3615 Civic Center Blvd, ARC, Rm. 316F, Philadelphia, PA 19104, USA, Tel.: +1 215 590 4667, Fax: +1 267 426 5476, E-mail:

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http://dx.doi.org/10.1160/TH16-02-0162DOI Listing
October 2016

Controversies in the treatment of immune thrombocytopenia.

Authors:
Adam Cuker Douglas B Cines Cindy E Neunert

Curr Opin Hematol 2016 09;23(5):479-85

aDepartment of Medicine bDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania cDepartment of Pediatrics, Columbia University, New York City, New York, USA.

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http://dx.doi.org/10.1097/MOH.0000000000000270DOI Listing
September 2016

Tissue-Type Plasminogen Activator-A296-299 Prevents Impairment of Cerebral Autoregulation After Stroke Through Lipoprotein-Related Receptor-Dependent Increase in cAMP and p38.

Authors:
William M Armstead John Riley Serge Yarovoi Abd Al-Roof Higazi Douglas B Cines

Stroke 2016 08 28;47(8):2096-102. Epub 2016 Jun 28.

From the Departments of Anesthesiology and Critical Care (W.M.A., J.R.), Pharmacology (W.M.A.), and Pathology and Laboratory Medicine (S.Y., A.A.-R.H., D.B.C.), University of Pennsylvania, Philadelphia; and Department of Clinical Biochemistry Hebrew University-Hadassah Medical School, Jerusalem, Israel (A.A.-R.H.).

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http://dx.doi.org/10.1161/STROKEAHA.116.012678DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4961526PMC
August 2016

Platelet Factor 4 Inhibits and Enhances HIV-1 Infection in a Concentration-Dependent Manner by Modulating Viral Attachment.

Authors:
Zahra F Parker Ann H Rux Amber M Riblett Fang-Hua Lee Lubica Rauova Douglas B Cines Mortimer Poncz Bruce S Sachais Robert W Doms

AIDS Res Hum Retroviruses 2016 07 15;32(7):705-17. Epub 2016 Mar 15.

1 Department of Microbiology, University of Pennsylvania School of Medicine , Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1089/AID.2015.0344DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931766PMC
July 2016

Atomic features of an autoantigen in heparin-induced thrombocytopenia (HIT).

Authors:
Zheng Cai Zhiqiang Zhu Mark I Greene Douglas B Cines

Autoimmun Rev 2016 Jul 9;15(7):752-5. Epub 2016 Mar 9.

Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1016/j.autrev.2016.03.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4875785PMC
July 2016

ADAMTS13 autoantibodies cloned from patients with acquired thrombotic thrombocytopenic purpura: 2. Pathogenicity in an animal model.

Authors:
Eric M Ostertag Khalil Bdeir Stephen Kacir Michelle Thiboutot Gayathri Gulendran Lenka Yunk Vincent M Hayes David G Motto Mortimer Poncz X Long Zheng Douglas B Cines Don L Siegel

Transfusion 2016 07 4;56(7):1775-85. Epub 2016 Apr 4.

Department of Pathology & Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1111/trf.13583DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4938757PMC
July 2016

ADAMTS13 autoantibodies cloned from patients with acquired thrombotic thrombocytopenic purpura: 1. Structural and functional characterization in vitro.

Authors:
Eric M Ostertag Stephen Kacir Michelle Thiboutot Gayathri Gulendran X Long Zheng Douglas B Cines Don L Siegel

Transfusion 2016 07 4;56(7):1763-74. Epub 2016 Apr 4.

Department of Pathology & Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1111/trf.13584DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4938786PMC
July 2016

Urokinase-type Plasminogen Activator (uPA) Promotes Angiogenesis by Attenuating Proline-rich Homeodomain Protein (PRH) Transcription Factor Activity and De-repressing Vascular Endothelial Growth Factor (VEGF) Receptor Expression.

Authors:
Victoria Stepanova Padma-Sheela Jayaraman Sergei V Zaitsev Tatiana Lebedeva Khalil Bdeir Rachael Kershaw Kelci R Holman Yelena V Parfyonova Ekaterina V Semina Irina B Beloglazova Vsevolod A Tkachuk Douglas B Cines

J Biol Chem 2016 07 4;291(29):15029-45. Epub 2016 May 4.

From the Departments of Pathology and Laboratory Medicine and.

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http://dx.doi.org/10.1074/jbc.M115.678490DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4946921PMC
July 2016

Human neutrophil peptides inhibit cleavage of von Willebrand factor by ADAMTS13: a potential link of inflammation to TTP.

Authors:
Vikram G Pillai Jialing Bao Catherine B Zander Jenny K McDaniel Palaniappan S Chetty Steven H Seeholzer Khalil Bdeir Douglas B Cines X Long Zheng

Blood 2016 07 13;128(1):110-9. Epub 2016 May 13.

Division of Laboratory Medicine, Department of Pathology, University of Alabama at Birmingham, Birmingham, AL;

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http://dx.doi.org/10.1182/blood-2015-12-688747DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4937355PMC
July 2016

α-Defensins Induce a Post-translational Modification of Low Density Lipoprotein (LDL) That Promotes Atherosclerosis at Normal Levels of Plasma Cholesterol.

Authors:
Rami Abu-Fanne Emad Maraga Ihab Abd-Elrahman Aviel Hankin Galia Blum Suhair Abdeen Nuha Hijazi Douglas B Cines Abd Al-Roof Higazi

J Biol Chem 2016 Feb 30;291(6):2777-86. Epub 2015 Oct 30.

From the Department of Clinical Biochemistry and the Department of Pathology and Laboratory Medicine, Perelman School of Medicine-University of Pennsylvania, Philadelphia, Pennsylvania 19104

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http://www.jbc.org/lookup/doi/10.1074/jbc.M115.669812
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http://dx.doi.org/10.1074/jbc.M115.669812DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4742743PMC
February 2016

A chimeric platelet-targeted urokinase prodrug selectively blocks new thrombus formation.

Authors:
Rudy E Fuentes Sergei Zaitsev Hyun Sook Ahn Vincent Hayes M Anna Kowalska Michele P Lambert Yuhuan Wang Donald L Siegel Daniel W Bougie Richard H Aster Daniel D Myers Victoria Stepanova Douglas B Cines Vladimir R Muzykantov Mortimer Poncz

J Clin Invest 2016 Feb;126(2):483-94

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http://dx.doi.org/10.1172/JCI81470DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4731161PMC
February 2016

Platelet transactivation by monocytes promotes thrombosis in heparin-induced thrombocytopenia.

Authors:
Valerie Tutwiler Daria Madeeva Hyun Sook Ahn Izabella Andrianova Vincent Hayes X Long Zheng Douglas B Cines Steven E McKenzie Mortimer Poncz Lubica Rauova

Blood 2016 Jan 30;127(4):464-72. Epub 2015 Oct 30.

Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia PA; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2013-11-53
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http://dx.doi.org/10.1182/blood-2013-11-539262DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4731847PMC
January 2016

Kinetics and mechanics of clot contraction are governed by the molecular and cellular composition of the blood.

Authors:
Valerie Tutwiler Rustem I Litvinov Andrey P Lozhkin Alina D Peshkova Tatiana Lebedeva Fazoil I Ataullakhanov Kara L Spiller Douglas B Cines John W Weisel

Blood 2016 Jan 24;127(1):149-59. Epub 2015 Nov 24.

Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA;

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http://www.bloodjournal.org/content/early/2015/11/24/blood-2
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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2015-05-64
Publisher Site
http://dx.doi.org/10.1182/blood-2015-05-647560DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4705605PMC
January 2016

Integrated analysis of long-term safety in patients with chronic immune thrombocytopaenia (ITP) treated with the thrombopoietin (TPO) receptor agonist romiplostim.

Authors:
Douglas B Cines Terry Gernsheimer Jeffrey Wasser Bertrand Godeau Drew Provan Roger Lyons Ivy Altomare Xuena Wang Angela Lopez

Int J Hematol 2015 Sep 23;102(3):259-70. Epub 2015 Jul 23.

Departments of Pathology and Laboratory Medicine, Perelman-University of Pennsylvania School of Medicine, 513 A Stellar Chance, 422 Curie Blvd, Philadelphia, PA, 19104, USA,

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September 2015

Atomic description of the immune complex involved in heparin-induced thrombocytopenia.

Authors:
Zheng Cai Serge V Yarovoi Zhiqiang Zhu Lubica Rauova Vincent Hayes Tatiana Lebedeva Qun Liu Mortimer Poncz Gowthami Arepally Douglas B Cines Mark I Greene

Nat Commun 2015 Sep 22;6:8277. Epub 2015 Sep 22.

Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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September 2015

Delivery of drugs bound to erythrocytes: new avenues for an old intravascular carrier.

Authors:
Carlos H Villa Daniel C Pan Sergei Zaitsev Douglas B Cines Donald L Siegel Vladimir R Muzykantov

Ther Deliv 2015 Jul;6(7):795-826

Department of Systems Pharmacology & Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.4155/tde.15.34DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4712023PMC
July 2015

Can immune thrombocytopenia be cured with medical therapy?

Authors:
Adam Cuker Eline T Luning Prak Douglas B Cines

Semin Thromb Hemost 2015 Jun 20;41(4):395-404. Epub 2015 Mar 20.

Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.

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June 2015

Platelet-delivered ADAMTS13 inhibits arterial thrombosis and prevents thrombotic thrombocytopenic purpura in murine models.

Authors:
Brandy Pickens Yingying Mao Dengju Li Don L Siegel Mortimer Poncz Douglas B Cines X Long Zheng

Blood 2015 May 23;125(21):3326-34. Epub 2015 Mar 23.

Department of Pathology and Department of Laboratory Medicine, The University of Pennsylvania, Philadelphia, PA; Division of Laboratory Medicine, Department of Pathology, The University of Alabama at Birmingham, Birmingham, AL.

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http://dx.doi.org/10.1182/blood-2014-07-587139DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4440884PMC
May 2015

Endogenous plasminogen activators mediate progressive intracerebral hemorrhage after traumatic brain injury in mice.

Authors:
Nuha Hijazi Rami Abu Fanne Rinat Abramovitch Serge Yarovoi Muhamed Higazi Suhair Abdeen Maamon Basheer Emad Maraga Douglas B Cines Abd Al-Roof Higazi

Blood 2015 Apr 11;125(16):2558-67. Epub 2015 Feb 11.

Department of Clinical Biochemistry and Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.

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April 2015

T2 magnetic resonance: a diagnostic platform for studying integrated hemostasis in whole blood--proof of concept.

Authors:
Lynell R Skewis Tatiana Lebedeva Vyacheslav Papkov Edward C Thayer Walter Massefski Adam Cuker Chandrasekaran Nagaswami Rustem I Litvinov M Anna Kowalska Lubica Rauova Mortimer Poncz John W Weisel Thomas J Lowery Douglas B Cines

Clin Chem 2014 Sep 23;60(9):1174-82. Epub 2014 Jun 23.

Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104;

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September 2014

Pathogenesis of immune thrombocytopenia.

Authors:
Douglas B Cines Adam Cuker John W Semple

Presse Med 2014 Apr 12;43(4 Pt 2):e49-59. Epub 2014 Mar 12.

The Keenan Research Centre for Biomedical Science in St. Michael's Hospital, Departments of Laboratory Medicine and Pathobiology, Toronto, ON M5B 1W8, Canada.

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April 2014

Clot contraction: compression of erythrocytes into tightly packed polyhedra and redistribution of platelets and fibrin.

Authors:
Douglas B Cines Tatiana Lebedeva Chandrasekaran Nagaswami Vincent Hayes Walter Massefski Rustem I Litvinov Lubica Rauova Thomas J Lowery John W Weisel

Blood 2014 Mar 13;123(10):1596-603. Epub 2013 Dec 13.

Department of Pathology and Laboratory Medicine and.

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http://dx.doi.org/10.1182/blood-2013-08-523860DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3945867PMC
March 2014

PAI-1-derived peptide EEIIMD prevents hypoxia/ischemia-induced aggravation of endothelin- and thromboxane-induced cerebrovasoconstriction.

Authors:
William M Armstead John Riley Douglas B Cines Abd Al-Roof Higazi

Neurocrit Care 2014 Feb;20(1):111-8

Department of Anesthesiology and Critical Care, University of Pennsylvania, 3620 Hamilton Walk, JM3, Philadelphia, PA, l9l04, USA,

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http://dx.doi.org/10.1007/s12028-013-9906-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4423732PMC
February 2014

tPA-S(481)A prevents impairment of cerebrovascular autoregulation by endogenous tPA after traumatic brain injury by upregulating p38 MAPK and inhibiting ET-1.

Authors:
William M Armstead Leif-Erik Bohman John Riley Serge Yarovoi Abd Al-Roof Higazi Douglas B Cines

J Neurotrauma 2013 Nov 24;30(22):1898-907. Epub 2013 Aug 24.

1 Department of Anesthesiology and Critical Care, University of Pennsylvania , Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1089/neu.2013.2962DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3814982PMC
November 2013

Distinct specificity and single-molecule kinetics characterize the interaction of pathogenic and non-pathogenic antibodies against platelet factor 4-heparin complexes with platelet factor 4.

Authors:
Rustem I Litvinov Serge V Yarovoi Lubica Rauova Valeri Barsegov Bruce S Sachais Ann H Rux Jillian L Hinds Gowthami M Arepally Douglas B Cines John W Weisel

J Biol Chem 2013 Nov 4;288(46):33060-70. Epub 2013 Oct 4.

From the Department of Cell and Developmental Biology and.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3829155PMC
November 2013

Bad (or good) things come in small packages.

Authors:
Lubica Rauova Douglas B Cines

Blood 2013 Nov;122(23):3707-8

UNIVERSITY OF PENNSYLVANIA;

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3843233PMC
November 2013

Multifunctional roles of urokinase plasminogen activator (uPA) in cancer stemness and chemoresistance of pancreatic cancer.

Authors:
Swapna Asuthkar Victoria Stepanova Tatiana Lebedeva Aixuan L Holterman Norman Estes Douglas B Cines Jasti S Rao Christopher S Gondi

Mol Biol Cell 2013 Sep 17;24(17):2620-32. Epub 2013 Jul 17.

Department of Cancer Biology and Pharmacology, University of Illinois College of Medicine at Peoria, Peoria, IL 61605, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3756915PMC
September 2013

TMA: beware of complements.

Authors:
Daniel Ricklin Douglas B Cines

Blood 2013 Sep;122(12):1997-9

PERELMAN-UNIVERSITY OF PENNSYLVANIA SCHOOL OF MEDICINE.

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http://dx.doi.org/10.1182/blood-2013-07-512707DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3778545PMC
September 2013

Domain 2 of uPAR regulates single-chain urokinase-mediated angiogenesis through β1-integrin and VEGFR2.

Authors:
Gretchen A Larusch Alona Merkulova Fakhri Mahdi Zia Shariat-Madar Robert G Sitrin Douglas B Cines Alvin H Schmaier

Am J Physiol Heart Circ Physiol 2013 Aug 24;305(3):H305-20. Epub 2013 May 24.

Division of Hematology and Oncology, Department of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.

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http://dx.doi.org/10.1152/ajpheart.00110.2013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3742872PMC
August 2013

Advanced drug delivery systems for antithrombotic agents.

Authors:
Colin F Greineder Melissa D Howard Ronald Carnemolla Douglas B Cines Vladimir R Muzykantov

Blood 2013 Aug 24;122(9):1565-75. Epub 2013 Jun 24.

Department of Pharmacology and Center for Targeted Therapeutics and Translational Nanomedicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757370PMC
August 2013

Novel diagnostic assays for heparin-induced thrombocytopenia.

Authors:
Adam Cuker Ann H Rux Jillian L Hinds May Dela Cruz Serge V Yarovoi Isola A M Brown Wei Yang Barbara A Konkle Gowthami M Arepally Stephen P Watson Douglas B Cines Bruce S Sachais

Blood 2013 May 27;121(18):3727-32. Epub 2013 Feb 27.

Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.1182/blood-2013-01-479576DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3643769PMC
May 2013

Standardization of bleeding assessment in immune thrombocytopenia: report from the International Working Group.

Authors:
Francesco Rodeghiero Marc Michel Terry Gernsheimer Marco Ruggeri Victor Blanchette James B Bussel Douglas B Cines Nichola Cooper Bertrand Godeau Andreas Greinacher Paul Imbach Mehdi Khellaf Robert J Klaassen Thomas Kühne Howard Liebman Maria Gabriella Mazzucconi Adrian Newland Ingrid Pabinger Alberto Tosetto Roberto Stasi

Blood 2013 Apr 29;121(14):2596-606. Epub 2013 Jan 29.

Department of Cell Therapy and Hematology, San Bortolo Hospital, Vicenza, Italy.

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http://dx.doi.org/10.1182/blood-2012-07-442392DOI Listing
April 2013

Protamine-induced thrombocytopenia?

Authors:
Adam Cuker Douglas B Cines

Blood 2013 Apr;121(15):2818-9

Perelman School of Medicine, University of Pennsylvania.

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http://dx.doi.org/10.1182/blood-2013-02-480467DOI Listing
April 2013

Innate and adaptive immunity in immune thrombocytopenia.

Authors:
Alan H Lazarus John W Semple Douglas B Cines

Semin Hematol 2013 Jan;50 Suppl 1:S68-70

The Canadian Blood Services, Ottawa, Canada.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3691820PMC
January 2013

Antigen and substrate withdrawal in the management of autoimmune thrombotic disorders.

Authors:
Douglas B Cines Keith R McCrae X Long Zheng Bruce S Sachais Eline T Luning Prak Don L Siegel

Blood 2012 Nov 10;120(20):4134-42. Epub 2012 Sep 10.

Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104-4274, USA.

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http://dx.doi.org/10.1182/blood-2012-06-389445DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3501713PMC
November 2012

Contact with stroke.

Authors:
Abd Al-Roof Higazi Douglas B Cines

Blood 2012 Nov;120(19):3870-1

Perelman School of Medicine.

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November 2012

Quantitative analysis of thrombomodulin-mediated conversion of protein C to APC: translation from in vitro to in vivo.

Authors:
Ronald Carnemolla Kruti Rajan Patel Sergei Zaitsev Douglas B Cines Charles T Esmon Vladimir R Muzykantov

J Immunol Methods 2012 Oct 27;384(1-2):21-4. Epub 2012 Jun 27.

Department of Pharmacology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1016/j.jim.2012.06.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3443618PMC
October 2012

Dynamic antibody-binding properties in the pathogenesis of HIT.

Authors:
Bruce S Sachais Rustem I Litvinov Serge V Yarovoi Lubica Rauova Jillian L Hinds Ann H Rux Gowthami M Arepally Mortimer Poncz Adam Cuker John W Weisel Douglas B Cines

Blood 2012 Aug 10;120(5):1137-42. Epub 2012 May 10.

Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1182/blood-2012-01-407262DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3412334PMC
August 2012

How I treat immune thrombocytopenia: the choice between splenectomy or a medical therapy as a second-line treatment.

Authors:
Waleed Ghanima Bertrand Godeau Douglas B Cines James B Bussel

Blood 2012 Aug 26;120(5):960-9. Epub 2012 Jun 26.

Department of Pediatric Hematology/Oncology, Weill Cornell Medical College, New York, NY 10065, USA.

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August 2012

Combination therapy with glucagon and a novel plasminogen activator inhibitor-1-derived peptide enhances protection against impaired cerebrovasodilation during hypotension after traumatic brain injury through inhibition of ERK and JNK MAPK.

Authors:
William M Armstead John Riley Douglas B Cines Abd Al-Roof Higazi

Neurol Res 2012 Jul 30;34(6):530-7. Epub 2012 May 30.

Department of Anesthesiology and Critical Care, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1179/1743132812Y.0000000039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3524516PMC
July 2012

tPA-S481A prevents neurotoxicity of endogenous tPA in traumatic brain injury.

Authors:
William M Armstead John Riley Serge Yarovoi Douglas B Cines Douglas H Smith Abd Al-Roof Higazi

J Neurotrauma 2012 Jun 30;29(9):1794-802. Epub 2012 Apr 30.

Department of Anesthesiology and Critical Care, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1089/neu.2012.2328DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3360893PMC
June 2012

Rational design and characterization of platelet factor 4 antagonists for the study of heparin-induced thrombocytopenia.

Authors:
Bruce S Sachais Ann H Rux Douglas B Cines Serge V Yarovoi Lee I Garner Stephen P Watson Jillian L Hinds John J Rux

Blood 2012 Jun 27;119(25):5955-62. Epub 2012 Mar 27.

Department of Pathology and Laboratory Medicine, Pearlman School of Medicine, University of Pennsylvania, 605A Stellar-Chance Labs, 422 Curie Blvd, Philadelphia, PA 19104, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3383011PMC
June 2012

Targeting recombinant thrombomodulin fusion protein to red blood cells provides multifaceted thromboprophylaxis.

Authors:
Sergei Zaitsev M Anna Kowalska Michael Neyman Ronald Carnemolla Samira Tliba Bi-Sen Ding Aaron Stonestrom Dirk Spitzer John P Atkinson Mortimer Poncz Douglas B Cines Charles T Esmon Vladimir R Muzykantov

Blood 2012 May 4;119(20):4779-85. Epub 2012 Apr 4.

Program in Targeted Therapeutics, Institute for Translational Medicine and Therapeutics, and Department of Pharmacology, University of Pennsylvania School of Medicine, 3400 Civic Center Blvd., Philadelphia, PA 19104-5158, USA.

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http://dx.doi.org/10.1182/blood-2011-12-398149DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3367878PMC
May 2012

Fibulin-5 binds urokinase-type plasminogen activator and mediates urokinase-stimulated β1-integrin-dependent cell migration.

Authors:
Alexander Kapustin Victoria Stepanova Natalia Aniol Douglas B Cines Alexei Poliakov Serge Yarovoi Tatiana Lebedeva Robin Wait Grigory Ryzhakov Yelena Parfyonova Yaroslav Gursky Hiromi Yanagisawa Mikhail Minashkin Robert Beabealashvilli Alexander Vorotnikov Alex Bobik Vsevolod Tkachuk

Biochem J 2012 Apr;443(2):491-503

Faculty of Fundamental Medicine, MV Lomonosov Moscow State University, Moscow, Russia.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4591041PMC
April 2012

Avoiding intuxication.

Authors:
James B Bussel Douglas B Cines

Blood 2012 Apr;119(16):3648-9

NYPH-Weill Medical College of Cornell University, USA.

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April 2012

How I treat heparin-induced thrombocytopenia.

Authors:
Adam Cuker Douglas B Cines

Blood 2012 Mar 13;119(10):2209-18. Epub 2012 Jan 13.

Departments of Medicine, University of Pennsylvania, Philadelphia, USA.

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http://dx.doi.org/10.1182/blood-2011-11-376293DOI Listing
March 2012

RBC-coupled tPA Prevents Whereas tPA Aggravates JNK MAPK-Mediated Impairment of ATP- and Ca-Sensitive K Channel-Mediated Cerebrovasodilation After Cerebral Photothrombosis.

Authors:
William M Armstead Kumkum Ganguly John Riley Sergei Zaitsev Douglas B Cines Abd Al-Roof Higazi Vladimir R Muzykantov

Transl Stroke Res 2012 Mar;3(1):114-21

Departments of Anesthesiology and Critical Care, University of Pennsylvania, 3620 Hamilton Walk, JM3, Philadelphia, PA 19104, USA. Pharmacology, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1007/s12975-011-0105-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3619434PMC
March 2012

Clinical trial opportunities in hemostasis and thrombosis: NHBLI State-of-the-Science symposium.

Authors:
Douglas B Cines Morris A Blajchman Katherine A High James B Bussel

Am J Hematol 2012 Feb 25;87(2):235-8. Epub 2011 Nov 25.

Department of Pathology and Laboratory Medicine and Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1002/ajh.22225DOI Listing
February 2012

False normal von Willebrand factor activity by monoclonal antibody-based ELISA in a patient with type 2A(IID) von Willebrand disease.

Authors:
Sufian Ahmad Beverly Ptashkin Cara DiGiovanni Douglas B Cines Barbara A Konkle Adam Cuker

Thromb Haemost 2011 Dec 6;106(6):1224-5. Epub 2011 Oct 6.

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http://dx.doi.org/10.1160/TH11-07-0484DOI Listing
December 2011

Red blood cell-coupled tissue plasminogen activator prevents impairment of cerebral vasodilatory responses through inhibition of c-Jun-N-terminal kinase and potentiation of p38 mitogen-activated protein kinase after cerebral photothrombosis in the newborn pig.

Authors:
William M Armstead Kumkum Ganguly John Riley J Willis Kiessling Douglas B Cines Abd A R Higazi Sergei Zaitsev Vladimir R Muzykantov

Pediatr Crit Care Med 2011 Nov;12(6):e369-75

Department of Anesthesiology and Critical Care, University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.1097/PCC.0b013e3181fe40a7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3681424PMC
November 2011

Urokinase plasminogen activator regulates pulmonary arterial contractility and vascular permeability in mice.

Authors:
Taher Nassar Serge Yarovoi Rami Abu Fanne Otailah Waked Timothy C Allen Steven Idell Douglas B Cines Abd Al-Roof Higazi

Am J Respir Cell Mol Biol 2011 Nov 26;45(5):1015-21. Epub 2011 May 26.

Department of Pathology, Laboratory Medicine, University of Pennsylvania, Philadelphia, 19104, USA.

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http://dx.doi.org/10.1165/rcmb.2010-0302OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3262683PMC
November 2011

tPA regulates pulmonary vascular activity through NMDA receptors.

Authors:
Taher Nassar Khalil Bdeir Serge Yarovoi Rami Abu Fanne Juan-Carlos Murciano Steven Idell Timothy Craig Allen Douglas B Cines Abd Al-Roof Higazi

Am J Physiol Lung Cell Mol Physiol 2011 Sep 13;301(3):L307-14. Epub 2011 May 13.

Dept. of Pathology and Laboratory Medicine, Univ. of Pennsylvania, 513A Stellar-Chance, 422 Curie Blvd., Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1152/ajplung.00429.2010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3174743PMC
September 2011

tPA contributes to impaired NMDA cerebrovasodilation after traumatic brain injury through activation of JNK MAPK.

Authors:
William M Armstead J Willis Kiessling John Riley Douglas B Cines Abd Al-Roof Higazi

Neurol Res 2011 Sep;33(7):726-33

Department of Anesthesiology and Critical Care, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1179/016164110X12807570509853DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3523283PMC
September 2011

Antibodies associated with heparin-induced thrombocytopenia (HIT) inhibit activated protein C generation: new insights into the prothrombotic nature of HIT.

Authors:
M Anna Kowalska Sriram Krishnaswamy Lubica Rauova Li Zhai Vincent Hayes Karine Amirikian Jeffrey D Esko Daniel W Bougie Richard H Aster Douglas B Cines Mortimer Poncz

Blood 2011 Sep 19;118(10):2882-8. Epub 2011 Jul 19.

Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3172804PMC
September 2011

Urokinase-type plasminogen activator (uPA) induces pulmonary microvascular endothelial permeability through low density lipoprotein receptor-related protein (LRP)-dependent activation of endothelial nitric-oxide synthase.

Authors:
Anastasia M Makarova Tatiana V Lebedeva Taher Nassar Abd Al-Roof Higazi Jing Xue Maria E Carinato Khalil Bdeir Douglas B Cines Victoria Stepanova

J Biol Chem 2011 Jul 3;286(26):23044-53. Epub 2011 May 3.

Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3123072PMC
July 2011

Flow-dependent channel formation in clots by an erythrocyte-bound fibrinolytic agent.

Authors:
Kathryn C Gersh Sergei Zaitsev Douglas B Cines Vladimir Muzykantov John W Weisel

Blood 2011 May 9;117(18):4964-7. Epub 2011 Mar 9.

Department of Cell & Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.

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http://dx.doi.org/10.1182/blood-2010-10-310409DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3100703PMC
May 2011

Immune thrombocytopenia.

Authors:
Adam Cuker Douglas B Cines

Hematology Am Soc Hematol Educ Program 2010 ;2010:377-84

Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1182/asheducation-2010.1.377DOI Listing
April 2011

Evidence-based mini-review: Is indium-labeled autologous platelet scanning predictive of response to splenectomy in patients with chronic immune thrombocytopenia?

Authors:
Adam Cuker Douglas B Cines

Hematology Am Soc Hematol Educ Program 2010 ;2010:385-6

Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1182/asheducation-2010.1.385DOI Listing
April 2011

Glucagon protects against impaired NMDA-mediated cerebrovasodilation and cerebral autoregulation during hypotension after brain injury by activating cAMP protein kinase A and inhibiting upregulation of tPA.

Authors:
William M Armstead J Willis Kiessling Douglas B Cines Abd Al-Roof Higazi

J Neurotrauma 2011 Mar 4;28(3):451-7. Epub 2011 Mar 4.

Department of Anesthesiology and Critical Care, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1089/neu.2010.1659DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3057207PMC
March 2011

tPA contributes to impairment of ATP and Ca sensitive K channel mediated cerebrovasodilation after hypoxia/ischemia through upregulation of ERK MAPK.

Authors:
William M Armstead John Riley Douglas B Cines Abd Al-Roof Higazi

Brain Res 2011 Feb 20;1376:88-93. Epub 2010 Dec 20.

Department of Anesthesiology and Critical Care, University of Pennsylvania, Philadelphia, PA l9l04, USA.

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http://dx.doi.org/10.1016/j.brainres.2010.12.052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3038175PMC
February 2011

Regulation of airway contractility by plasminogen activators through N-methyl-D-aspartate receptor-1.

Authors:
Taher Nassar Serge Yarovoi Rami Abu Fanne Sa'ed Akkawi Mahmud Jammal Timothy Craig Allen Steven Idell Douglas B Cines Abd Al-Roof Higazi

Am J Respir Cell Mol Biol 2010 Dec 22;43(6):703-11. Epub 2010 Jan 22.

Department of Pathology and Laboratory Medicine, University of Pennsylvania, 513A Stellar-Chance, 422 Curie Boulevard, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1165/rcmb.2009-0257OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2993090PMC
December 2010

Urokinase-type plasminogen activator inhibits efferocytosis of neutrophils.

Authors:
Yanping Yang Arnaud Friggeri Sami Banerjee Khalil Bdeir Douglas B Cines Gang Liu Edward Abraham

Am J Respir Crit Care Med 2010 Dec 23;182(12):1516-23. Epub 2010 Jul 23.

Department of Medicine, University of Alabama at Birmingham, 35294, USA.

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http://dx.doi.org/10.1164/rccm.201003-0452OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3029937PMC
December 2010

Monocyte-bound PF4 in the pathogenesis of heparin-induced thrombocytopenia.

Authors:
Lubica Rauova Jessica D Hirsch Teshell K Greene Li Zhai Vincent M Hayes M Anna Kowalska Douglas B Cines Mortimer Poncz

Blood 2010 Dec 19;116(23):5021-31. Epub 2010 Aug 19.

Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2010-03-27
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http://dx.doi.org/10.1182/blood-2010-03-276964DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3012595PMC
December 2010

Novel plasminogen activator inhibitor-1-derived peptide protects against impairment of cerebrovasodilation after photothrombosis through inhibition of JNK MAPK.

Authors:
William M Armstead John Riley J Willis Kiessling Douglas B Cines Abd Al-Roof Higazi

Am J Physiol Regul Integr Comp Physiol 2010 Aug 10;299(2):R480-5. Epub 2010 Jun 10.

Dept. of Anesthesiology and Critical Care, 3620 Hamilton Walk, JM3, Univ. of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1152/ajpregu.00256.2010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2928614PMC
August 2010

Future research in ITP: an ICIS consensus.

Authors:
James L Zehnder John W Semple Paul Imbach Ellis J Neufeld George R Buchanan Douglas B Cines

Ann Hematol 2010 Jul 23;89 Suppl 1:19-23. Epub 2010 Mar 23.

Department of Pathology, Stanford University School of Medicine, L235, Stanford, CA, 94305, USA,

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http://dx.doi.org/10.1007/s00277-010-0917-1DOI Listing
July 2010

PAI-1-derived peptide EEIIMD prevents impairment of cerebrovasodilation by augmenting p38 MAPK upregulation after cerebral hypoxia/ischemia.

Authors:
William M Armstead John Riley J Willis Kiessling Douglas B Cines Abd Al-Roof Higazi

Am J Physiol Heart Circ Physiol 2010 Jul 30;299(1):H76-80. Epub 2010 Apr 30.

Department of Anesthesiology and Critical Care, University of Pennsylvania, 3620 Hamilton Walk, Philadelphia, PA 19104, USA.

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http://www.physiology.org/doi/10.1152/ajpheart.00185.2010
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http://dx.doi.org/10.1152/ajpheart.00185.2010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2904139PMC
July 2010

Blood-brain barrier permeability and tPA-mediated neurotoxicity.

Authors:
Rami Abu Fanne Taher Nassar Sergei Yarovoi Anwar Rayan Itschak Lamensdorf Michael Karakoveski Polianski Vadim Mahmud Jammal Douglas B Cines Abd Al-Roof Higazi

Neuropharmacology 2010 Jun 6;58(7):972-80. Epub 2010 Jan 6.

Department of Clinical Biochemistry, Hebrew University - Hadassah Medical Center, Jerusalem, Israel.

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http://dx.doi.org/10.1016/j.neuropharm.2009.12.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4423729PMC
June 2010

Induction of tissue factor by urokinase in lung epithelial cells and in the lungs.

Authors:
Sreerama Shetty Yashodhar P Bhandary Shwetha K Shetty Thirunavukkarasu Velusamy Praveenkumar Shetty Khalil Bdeir Margaret R Gyetko Douglas B Cines Steven Idell Pierre F Neuenschwander Clemens Ruppert Andreas Guenther Edward Abraham Rashmi S Shetty

Am J Respir Crit Care Med 2010 Jun 1;181(12):1355-66. Epub 2010 Mar 1.

Department of Specialty Care Services, The Texas Lung Injury Institute, University of Texas Health Center at Tyler, 11937 US Highway 271, Tyler, TX 75708, USA.

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http://www.atsjournals.org/doi/abs/10.1164/rccm.200901-0015O
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http://dx.doi.org/10.1164/rccm.200901-0015OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2894411PMC
June 2010

Sustained thromboprophylaxis mediated by an RBC-targeted pro-urokinase zymogen activated at the site of clot formation.

Authors:
Sergei Zaitsev Dirk Spitzer Juan-Carlos Murciano Bi-Sen Ding Samira Tliba M Anna Kowalska Oscar A Marcos-Contreras Alice Kuo Victoria Stepanova John P Atkinson Mortimer Poncz Douglas B Cines Vladimir R Muzykantov

Blood 2010 Jun 21;115(25):5241-8. Epub 2010 Apr 21.

Program in Targeted Therapeutics, Institute for Translational Medicine and Therapeutics and Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia 19104-6068, USA.

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http://dx.doi.org/10.1182/blood-2010-01-261610DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2892950PMC
June 2010

Neutrophil alpha-defensins cause lung injury by disrupting the capillary-epithelial barrier.

Authors:
Khalil Bdeir Abd Al-Roof Higazi Irina Kulikovskaya Melpo Christofidou-Solomidou Sergei A Vinogradov Timothy C Allen Steven Idell Rose Linzmeier Tomas Ganz Douglas B Cines

Am J Respir Crit Care Med 2010 May 21;181(9):935-46. Epub 2010 Jan 21.

Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA l9l04, USA.

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http://www.atsjournals.org/doi/abs/10.1164/rccm.200907-1128O
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http://dx.doi.org/10.1164/rccm.200907-1128OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2862305PMC
May 2010

Signaling, delivery and age as emerging issues in the benefit/risk ratio outcome of tPA For treatment of CNS ischemic disorders.

Authors:
William M Armstead Kumkum Ganguly J W Kiessling John Riley Xiao-Han Chen Douglas H Smith Sherman C Stein Abd A R Higazi Douglas B Cines Khalil Bdeir Sergei Zaitsev Vladimir R Muzykantov

J Neurochem 2010 Apr;113(2):303-12

Department of Anesthesiology and Critical Care, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3467975PMC
http://dx.doi.org/10.1111/j.1471-4159.2010.06613.xDOI Listing
April 2010

Targeting of a mutant plasminogen activator to circulating red blood cells for prophylactic fibrinolysis.

Authors:
Sergei Zaitsev Sergei Zaitzev Dirk Spitzer Juan-Carlos Murciano Bi-Sen Ding Samira Tliba M Anna Kowalska Khalil Bdeir Alice Kuo Victoria Stepanova John P Atkinson Mortimer Poncz Douglas B Cines Vladimir R Muzykantov

J Pharmacol Exp Ther 2010 Mar 1;332(3):1022-31. Epub 2009 Dec 1.

IFEM, University of Pennsylvania School of Medicine, One John Morgan Building, 3620 Hamilton Walk, Philadelphia, PA 19104-6068, USA.

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http://dx.doi.org/10.1124/jpet.109.159194DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2835436PMC
March 2010