Douglas B Cines

COVID-19-associated Acute Respiratory Distress Syndrome Clarified: A Vascular Endotype?

Authors:

Nilam S Mangalmurti John P Reilly Douglas B Cines Nuala J Meyer Christopher A Hunter Andrew E Vaughan

Am J Respir Crit Care Med 2020 09;202(5):750-753

University of Pennsylvania School of Veterinary Medicine Philadelphia, Pennsylvania.

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September 2020

Erythrocytes Reveal Complement Activation in Patients with COVID-19.

Authors:

Lk Metthew Lam Sophie J Murphy Leticia Kuri-Cervantes Ariel R Weisman Caroline A G Ittner John P Reilly M Betina Pampena Michael R Betts E John Wherry Wen-Chao Song John D Lambris Douglas B Cines Nuala J Meyer Nilam S Mangalmurti

medRxiv 2020 May 22. Epub 2020 May 22.

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May 2020

Pathogenesis of heparin-induced thrombocytopenia.

Authors:

Gowthami M Arepally Douglas B Cines

Transl Res 2020 11 15;225:131-140. Epub 2020 May 15.

Department of Pathology and Laboratory Medicine, Perelman-University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania.

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November 2020

Opposing effects of HNP1 (α-defensin-1) on plasma cholesterol and atherogenesis.

Authors:

Mohamed Higazi Suhair Abdeen Rami Abu-Fanne Samuel N Heyman Aseel Masarwy Khalil Bdeir Emad Maraga Douglas B Cines Abd Al-Roof Higazi

PLoS One 2020 17;15(4):e0231582. Epub 2020 Apr 17.

Department of Clinical Biochemistry, Hadassah-Hebrew University, Jerusalem, Israel.

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July 2020

Diagnosing HIT: the need for speed.

Authors:

Adam Cuker Douglas B Cines

Blood 2020 04;135(14):1082-1083

University of Pennsylvania.

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April 2020

The distinctive structure and composition of arterial and venous thrombi and pulmonary emboli.

Authors:

Irina N Chernysh Chandrasekaran Nagaswami Sofia Kosolapova Alina D Peshkova Adam Cuker Douglas B Cines Carolyn L Cambor Rustem I Litvinov John W Weisel

Sci Rep 2020 03 20;10(1):5112. Epub 2020 Mar 20.

University of Pennsylvania School of Medicine, Philadelphia, PA, USA.

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March 2020

FcRn augments induction of tissue factor activity by IgG-containing immune complexes.

Authors:

Douglas B Cines Sergei Zaitsev Lubica Rauova Ann H Rux Victoria Stepanova Sriram Krishnaswamy Amrita Sarkar M Anna Kowalska Guohua Zhao Alan E Mast Laurence J Blumberg Keith R McCrae Mortimer Poncz Jonathan J Hubbard Michal Pyzik Richard S Blumberg

Blood 2020 Jun;135(23):2085-2093

Department of Cardiovascular and Metabolic Sciences, Cleveland Clinic, Cleveland, OH.

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June 2020

Recognition of PF4-VWF complexes by heparin-induced thrombocytopenia antibodies contributes to thrombus propagation.

Authors:

Ian Johnston Amrita Sarkar Vincent Hayes Gavin T Koma Gowthami M Arepally Junmei Chen Dominic W Chung José A López Douglas B Cines Lubica Rauova Mortimer Poncz

Blood 2020 04;135(15):1270-1280

Division of Hematology, The Children's Hospital of Philadelphia, Philadelphia, PA.

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April 2020

American Society of Hematology 2019 guidelines for immune thrombocytopenia.

Authors:

Cindy Neunert Deirdra R Terrell Donald M Arnold George Buchanan Douglas B Cines Nichola Cooper Adam Cuker Jenny M Despotovic James N George Rachael F Grace Thomas Kühne David J Kuter Wendy Lim Keith R McCrae Barbara Pruitt Hayley Shimanek Sara K Vesely

Blood Adv 2019 12;3(23):3829-3866

Department of Biostatistics and Epidemiology, Hudson College of Public Health, University of Oklahoma Health Sciences Center, Oklahoma City, OK.

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December 2019

Thrombocytopenia in pregnancy: Diagnosis and approach to management.

Authors:

Allyson M Pishko Lisa D Levine Douglas B Cines

Blood Rev 2020 03 6;40:100638. Epub 2019 Nov 6.

Departments of Pathology and Laboratory Medicine and Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

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March 2020

The child with immune thrombocytopenia: to treat or not to treat, is that still the question?

Authors:

Nichola Cooper Douglas B Cines

Haematologica 2019 11;104(11):2132-2134

Departments of Pathology and Laboratory Medicine and Medicine, University of Pennsylvania-Perelman School of Medicine, Philadelphia, PA, USA

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November 2019

The risk of major bleeding in patients with suspected heparin-induced thrombocytopenia.

Authors:

Allyson M Pishko Daniel S Lefler Phyllis Gimotty Koosha Paydary Sara Fardin Gowthami M Arepally Mark Crowther Lawrence Rice Rolando Vega Douglas B Cines James P Guevara Adam Cuker

J Thromb Haemost 2019 11 12;17(11):1956-1965. Epub 2019 Aug 12.

Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.

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November 2019

Human neutrophil peptide-1 inhibits thrombus formation under arterial flow via its terminal free cysteine thiols.

Authors:

Jenny K McDaniel Mohammad S Abdelgawwad Audra Hargett Matthew B Renfrow Khalil Bdeir Wenjing Cao Douglas B Cines X Long Zheng

J Thromb Haemost 2019 04 13;17(4):596-606. Epub 2019 Mar 13.

Division of Laboratory Medicine, Department of Pathology, The University of Alabama at Birmingham, Birmingham, AL, USA.

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April 2019

Blood clot contraction differentially modulates internal and external fibrinolysis.

Authors:

Valerie Tutwiler Alina D Peshkova Giang Le Minh Sergei Zaitsev Rustem I Litvinov Douglas B Cines John W Weisel

J Thromb Haemost 2019 02 6;17(2):361-370. Epub 2019 Feb 6.

Department of Cell and Developmental Biology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.

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February 2019

American Society of Hematology 2018 guidelines for management of venous thromboembolism: heparin-induced thrombocytopenia.

Authors:

Adam Cuker Gowthami M Arepally Beng H Chong Douglas B Cines Andreas Greinacher Yves Gruel Lori A Linkins Stephen B Rodner Sixten Selleng Theodore E Warkentin Ashleigh Wex Reem A Mustafa Rebecca L Morgan Nancy Santesso

Blood Adv 2018 11;2(22):3360-3392

Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, ON, Canada; and.

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November 2018

Prospective comparison of the HEP score and 4Ts score for the diagnosis of heparin-induced thrombocytopenia.

Authors:

Allyson M Pishko Sara Fardin Daniel S Lefler Koosha Paydary Rolando Vega Gowthami M Arepally Mark Crowther Lawrence Rice Douglas B Cines Adam Cuker

Blood Adv 2018 11;2(22):3155-3162

Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.

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November 2018

Neutrophil α-defensins promote thrombosis in vivo by altering fibrin formation, structure, and stability.

Authors:

Rami Abu-Fanne Victoria Stepanova Rustem I Litvinov Suhair Abdeen Khalil Bdeir Mohamed Higazi Emad Maraga Chandrasekaran Nagaswami Alexander R Mukhitov John W Weisel Douglas B Cines Abd Al-Roof Higazi

Blood 2019 01 15;133(5):481-493. Epub 2018 Nov 15.

Department of Clinical Biochemistry, Hadassah-Hebrew University, Jerusalem, Israel.

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January 2019

Polyreactive IgM initiates complement activation by PF4/heparin complexes through the classical pathway.

Authors:

Sanjay Khandelwal Joann Ravi Lubica Rauova Alexandra Johnson Grace M Lee Jennifer B Gilner Sreenivasulu Gunti Abner L Notkins Maragatha Kuchibhatla Michael Frank Mortimer Poncz Douglas B Cines Gowthami M Arepally

Blood 2018 12 11;132(23):2431-2440. Epub 2018 Oct 11.

Division of Hematology, Duke University Medical Center, Durham, NC.

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December 2018

Neutrophil accumulation and NET release contribute to thrombosis in HIT.

Authors:

Kandace Gollomp Minna Kim Ian Johnston Vincent Hayes John Welsh Gowthami M Arepally Mark Kahn Michele P Lambert Adam Cuker Douglas B Cines Lubica Rauova M Anna Kowalska Mortimer Poncz

JCI Insight 2018 09 20;3(18). Epub 2018 Sep 20.

Division of Hematology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.

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September 2018

T2 Magnetic Resonance to Monitor Hemostasis.

Authors:

Adam Cuker Joseph E Marturano Maria E Carinato Thomas J Lowery Douglas B Cines

Semin Thromb Hemost 2019 Apr 17;45(3):247-252. Epub 2018 Aug 17.

Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.

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April 2019

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