Douglas B Cines

Douglas B Cines

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The risk of major bleeding in patients with suspected heparin-induced thrombocytopenia.

J Thromb Haemost 2019 Jul 27. Epub 2019 Jul 27.

Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1111/jth.14587DOI Listing
July 2019

T2 Magnetic Resonance to Monitor Hemostasis.

Semin Thromb Hemost 2019 Apr 17;45(3):247-252. Epub 2018 Aug 17.

Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0038-1667114
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http://dx.doi.org/10.1055/s-0038-1667114DOI Listing
April 2019

Human neutrophil peptide-1 inhibits thrombus formation under arterial flow via its terminal free cysteine thiols.

J Thromb Haemost 2019 Apr 13;17(4):596-606. Epub 2019 Mar 13.

Division of Laboratory Medicine, Department of Pathology, The University of Alabama at Birmingham, Birmingham, AL, USA.

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http://dx.doi.org/10.1111/jth.14407DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443439PMC
April 2019

Blood clot contraction differentially modulates internal and external fibrinolysis.

J Thromb Haemost 2019 Feb 6;17(2):361-370. Epub 2019 Feb 6.

Department of Cell and Developmental Biology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.

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http://dx.doi.org/10.1111/jth.14370DOI Listing
February 2019

Molecular and cellular pathogenesis of heparin-induced thrombocytopenia (HIT).

Autoimmun Rev 2018 10 10;17(10):1046-1052. Epub 2018 Aug 10.

Department of Pathology and Laboratory Medicine, University of Pennsylvania, Perelman School of Medicine, USA; Department of Medicine, University of Pennsylvania, Perelman School of Medicine, USA. Electronic address:

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http://dx.doi.org/10.1016/j.autrev.2018.05.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6201246PMC
October 2018

Dynamic intercellular redistribution of HIT antigen modulates heparin-induced thrombocytopenia.

Blood 2018 08 18;132(7):727-734. Epub 2018 Jun 18.

Division of Hematology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA.

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http://dx.doi.org/10.1182/blood-2018-02-830737DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6097133PMC
August 2018

Management of antithrombotic therapy in adults with immune thrombocytopenia (ITP): a survey of ITP specialists and general hematologist-oncologists.

J Thromb Thrombolysis 2018 Jul;46(1):24-30

Department of Biostatistics and Epidemiology, College of Public Health, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.

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http://dx.doi.org/10.1007/s11239-018-1649-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355248PMC
July 2018

Biocompatible coupling of therapeutic fusion proteins to human erythrocytes.

Blood Adv 2018 02;2(3):165-176

Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA; and.

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http://www.bloodadvances.org/lookup/doi/10.1182/bloodadvance
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http://dx.doi.org/10.1182/bloodadvances.2017011734DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5812327PMC
February 2018

tPA variant tPA-A Prevents impairment of cerebral autoregulation and necrosis of hippocampal neurons after stroke by inhibiting upregulation of ET-1.

J Neurosci Res 2018 01 13;96(1):128-137. Epub 2017 Jul 13.

Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, l9l04.

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http://dx.doi.org/10.1002/jnr.24112DOI Listing
January 2018

Targeting plasminogen activator inhibitor-1 in tetracycline-induced pleural injury in rabbits.

Am J Physiol Lung Cell Mol Physiol 2018 01 31;314(1):L54-L68. Epub 2017 Aug 31.

Texas Lung Injury Institute, The University of Texas Health Science Center at Tyler , Tyler, Texas.

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http://dx.doi.org/10.1152/ajplung.00579.2016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6048456PMC
January 2018

Thrombocytopenia in pregnancy.

Hematology Am Soc Hematol Educ Program 2017 12;2017(1):144-151

Maternal and Child Health Research Center, Department of Obstetrics and Gynecology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.

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http://dx.doi.org/10.1182/asheducation-2017.1.144DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6142617PMC
December 2017

Thrombocytopenia in pregnancy.

Blood 2017 11 21;130(21):2271-2277. Epub 2017 Jun 21.

Maternal and Child Health Research Center, Department of Obstetrics and Gynecology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.

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http://dx.doi.org/10.1182/blood-2017-05-781971DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5701522PMC
November 2017

Erythrocytes as Carriers for Drug Delivery in Blood Transfusion and Beyond.

Transfus Med Rev 2017 01 17;31(1):26-35. Epub 2016 Aug 17.

Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.

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http://dx.doi.org/10.1016/j.tmrv.2016.08.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5161683PMC
January 2017

Role of monocytes and endothelial cells in heparin-induced thrombocytopenia.

Thromb Haemost 2016 Oct 4;116(5):806-812. Epub 2016 Aug 4.

Lubica Rauova, MD, PhD, The Children's Hospital of Philadelphia, 3615 Civic Center Blvd, ARC, Rm. 316F, Philadelphia, PA 19104, USA, Tel.: +1 215 590 4667, Fax: +1 267 426 5476, E-mail:

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http://dx.doi.org/10.1160/TH16-02-0162DOI Listing
October 2016

Controversies in the treatment of immune thrombocytopenia.

Curr Opin Hematol 2016 09;23(5):479-85

aDepartment of Medicine bDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania cDepartment of Pediatrics, Columbia University, New York City, New York, USA.

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http://dx.doi.org/10.1097/MOH.0000000000000270DOI Listing
September 2016

Tissue-Type Plasminogen Activator-A296-299 Prevents Impairment of Cerebral Autoregulation After Stroke Through Lipoprotein-Related Receptor-Dependent Increase in cAMP and p38.

Stroke 2016 08 28;47(8):2096-102. Epub 2016 Jun 28.

From the Departments of Anesthesiology and Critical Care (W.M.A., J.R.), Pharmacology (W.M.A.), and Pathology and Laboratory Medicine (S.Y., A.A.-R.H., D.B.C.), University of Pennsylvania, Philadelphia; and Department of Clinical Biochemistry Hebrew University-Hadassah Medical School, Jerusalem, Israel (A.A.-R.H.).

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http://dx.doi.org/10.1161/STROKEAHA.116.012678DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4961526PMC
August 2016

Platelet Factor 4 Inhibits and Enhances HIV-1 Infection in a Concentration-Dependent Manner by Modulating Viral Attachment.

AIDS Res Hum Retroviruses 2016 07 15;32(7):705-17. Epub 2016 Mar 15.

1 Department of Microbiology, University of Pennsylvania School of Medicine , Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1089/AID.2015.0344DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931766PMC
July 2016

Atomic features of an autoantigen in heparin-induced thrombocytopenia (HIT).

Autoimmun Rev 2016 Jul 9;15(7):752-5. Epub 2016 Mar 9.

Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1016/j.autrev.2016.03.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4875785PMC
July 2016

ADAMTS13 autoantibodies cloned from patients with acquired thrombotic thrombocytopenic purpura: 2. Pathogenicity in an animal model.

Transfusion 2016 07 4;56(7):1775-85. Epub 2016 Apr 4.

Department of Pathology & Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1111/trf.13583DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4938757PMC
July 2016

ADAMTS13 autoantibodies cloned from patients with acquired thrombotic thrombocytopenic purpura: 1. Structural and functional characterization in vitro.

Transfusion 2016 07 4;56(7):1763-74. Epub 2016 Apr 4.

Department of Pathology & Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1111/trf.13584DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4938786PMC
July 2016

α-Defensins Induce a Post-translational Modification of Low Density Lipoprotein (LDL) That Promotes Atherosclerosis at Normal Levels of Plasma Cholesterol.

J Biol Chem 2016 Feb 30;291(6):2777-86. Epub 2015 Oct 30.

From the Department of Clinical Biochemistry and the Department of Pathology and Laboratory Medicine, Perelman School of Medicine-University of Pennsylvania, Philadelphia, Pennsylvania 19104

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http://www.jbc.org/lookup/doi/10.1074/jbc.M115.669812
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http://dx.doi.org/10.1074/jbc.M115.669812DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4742743PMC
February 2016

Platelet transactivation by monocytes promotes thrombosis in heparin-induced thrombocytopenia.

Blood 2016 Jan 30;127(4):464-72. Epub 2015 Oct 30.

Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia PA; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2013-11-53
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http://dx.doi.org/10.1182/blood-2013-11-539262DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4731847PMC
January 2016

Integrated analysis of long-term safety in patients with chronic immune thrombocytopaenia (ITP) treated with the thrombopoietin (TPO) receptor agonist romiplostim.

Int J Hematol 2015 Sep 23;102(3):259-70. Epub 2015 Jul 23.

Departments of Pathology and Laboratory Medicine, Perelman-University of Pennsylvania School of Medicine, 513 A Stellar Chance, 422 Curie Blvd, Philadelphia, PA, 19104, USA,

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https://link.springer.com/content/pdf/10.1007%2Fs12185-015-1
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http://link.springer.com/10.1007/s12185-015-1837-6
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http://dx.doi.org/10.1007/s12185-015-1837-6DOI Listing
September 2015

Atomic description of the immune complex involved in heparin-induced thrombocytopenia.

Nat Commun 2015 Sep 22;6:8277. Epub 2015 Sep 22.

Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1038/ncomms9277DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4580983PMC
September 2015

Delivery of drugs bound to erythrocytes: new avenues for an old intravascular carrier.

Ther Deliv 2015 Jul;6(7):795-826

Department of Systems Pharmacology & Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.4155/tde.15.34DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4712023PMC
July 2015

Can immune thrombocytopenia be cured with medical therapy?

Semin Thromb Hemost 2015 Jun 20;41(4):395-404. Epub 2015 Mar 20.

Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1055/s-0034-1544001DOI Listing
June 2015

Platelet-delivered ADAMTS13 inhibits arterial thrombosis and prevents thrombotic thrombocytopenic purpura in murine models.

Blood 2015 May 23;125(21):3326-34. Epub 2015 Mar 23.

Department of Pathology and Department of Laboratory Medicine, The University of Pennsylvania, Philadelphia, PA; Division of Laboratory Medicine, Department of Pathology, The University of Alabama at Birmingham, Birmingham, AL.

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http://dx.doi.org/10.1182/blood-2014-07-587139DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4440884PMC
May 2015

T2 magnetic resonance: a diagnostic platform for studying integrated hemostasis in whole blood--proof of concept.

Clin Chem 2014 Sep 23;60(9):1174-82. Epub 2014 Jun 23.

Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104;

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http://www.clinchem.org/content/60/9/1174.full.pdf
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http://www.clinchem.org/cgi/doi/10.1373/clinchem.2014.223735
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http://dx.doi.org/10.1373/clinchem.2014.223735DOI Listing
September 2014

Pathogenesis of immune thrombocytopenia.

Presse Med 2014 Apr 12;43(4 Pt 2):e49-59. Epub 2014 Mar 12.

The Keenan Research Centre for Biomedical Science in St. Michael's Hospital, Departments of Laboratory Medicine and Pathobiology, Toronto, ON M5B 1W8, Canada.

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http://dx.doi.org/10.1016/j.lpm.2014.01.010DOI Listing
April 2014

PAI-1-derived peptide EEIIMD prevents hypoxia/ischemia-induced aggravation of endothelin- and thromboxane-induced cerebrovasoconstriction.

Neurocrit Care 2014 Feb;20(1):111-8

Department of Anesthesiology and Critical Care, University of Pennsylvania, 3620 Hamilton Walk, JM3, Philadelphia, PA, l9l04, USA,

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http://dx.doi.org/10.1007/s12028-013-9906-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4423732PMC
February 2014

tPA-S(481)A prevents impairment of cerebrovascular autoregulation by endogenous tPA after traumatic brain injury by upregulating p38 MAPK and inhibiting ET-1.

J Neurotrauma 2013 Nov 24;30(22):1898-907. Epub 2013 Aug 24.

1 Department of Anesthesiology and Critical Care, University of Pennsylvania , Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1089/neu.2013.2962DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3814982PMC
November 2013

Bad (or good) things come in small packages.

Blood 2013 Nov;122(23):3707-8

UNIVERSITY OF PENNSYLVANIA;

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http://dx.doi.org/10.1182/blood-2013-09-522482DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3843233PMC
November 2013

Multifunctional roles of urokinase plasminogen activator (uPA) in cancer stemness and chemoresistance of pancreatic cancer.

Mol Biol Cell 2013 Sep 17;24(17):2620-32. Epub 2013 Jul 17.

Department of Cancer Biology and Pharmacology, University of Illinois College of Medicine at Peoria, Peoria, IL 61605, USA.

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http://dx.doi.org/10.1091/mbc.E12-04-0306DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3756915PMC
September 2013

TMA: beware of complements.

Blood 2013 Sep;122(12):1997-9

PERELMAN-UNIVERSITY OF PENNSYLVANIA SCHOOL OF MEDICINE.

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http://dx.doi.org/10.1182/blood-2013-07-512707DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3778545PMC
September 2013

Domain 2 of uPAR regulates single-chain urokinase-mediated angiogenesis through β1-integrin and VEGFR2.

Am J Physiol Heart Circ Physiol 2013 Aug 24;305(3):H305-20. Epub 2013 May 24.

Division of Hematology and Oncology, Department of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.

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http://dx.doi.org/10.1152/ajpheart.00110.2013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3742872PMC
August 2013

Advanced drug delivery systems for antithrombotic agents.

Blood 2013 Aug 24;122(9):1565-75. Epub 2013 Jun 24.

Department of Pharmacology and Center for Targeted Therapeutics and Translational Nanomedicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1182/blood-2013-03-453498DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757370PMC
August 2013

Novel diagnostic assays for heparin-induced thrombocytopenia.

Blood 2013 May 27;121(18):3727-32. Epub 2013 Feb 27.

Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.1182/blood-2013-01-479576DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3643769PMC
May 2013

Protamine-induced thrombocytopenia?

Blood 2013 Apr;121(15):2818-9

Perelman School of Medicine, University of Pennsylvania.

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http://dx.doi.org/10.1182/blood-2013-02-480467DOI Listing
April 2013

Innate and adaptive immunity in immune thrombocytopenia.

Semin Hematol 2013 Jan;50 Suppl 1:S68-70

The Canadian Blood Services, Ottawa, Canada.

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http://dx.doi.org/10.1053/j.seminhematol.2013.03.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3691820PMC
January 2013

Antigen and substrate withdrawal in the management of autoimmune thrombotic disorders.

Blood 2012 Nov 10;120(20):4134-42. Epub 2012 Sep 10.

Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104-4274, USA.

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http://dx.doi.org/10.1182/blood-2012-06-389445DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3501713PMC
November 2012

Contact with stroke.

Blood 2012 Nov;120(19):3870-1

Perelman School of Medicine.

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http://dx.doi.org/10.1182/blood-2012-09-455154DOI Listing
November 2012

Quantitative analysis of thrombomodulin-mediated conversion of protein C to APC: translation from in vitro to in vivo.

J Immunol Methods 2012 Oct 27;384(1-2):21-4. Epub 2012 Jun 27.

Department of Pharmacology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1016/j.jim.2012.06.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3443618PMC
October 2012

Dynamic antibody-binding properties in the pathogenesis of HIT.

Blood 2012 Aug 10;120(5):1137-42. Epub 2012 May 10.

Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1182/blood-2012-01-407262DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3412334PMC
August 2012

How I treat immune thrombocytopenia: the choice between splenectomy or a medical therapy as a second-line treatment.

Blood 2012 Aug 26;120(5):960-9. Epub 2012 Jun 26.

Department of Pediatric Hematology/Oncology, Weill Cornell Medical College, New York, NY 10065, USA.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2011-12-30
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http://dx.doi.org/10.1182/blood-2011-12-309153DOI Listing
August 2012

tPA-S481A prevents neurotoxicity of endogenous tPA in traumatic brain injury.

J Neurotrauma 2012 Jun 30;29(9):1794-802. Epub 2012 Apr 30.

Department of Anesthesiology and Critical Care, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1089/neu.2012.2328DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3360893PMC
June 2012

Targeting recombinant thrombomodulin fusion protein to red blood cells provides multifaceted thromboprophylaxis.

Blood 2012 May 4;119(20):4779-85. Epub 2012 Apr 4.

Program in Targeted Therapeutics, Institute for Translational Medicine and Therapeutics, and Department of Pharmacology, University of Pennsylvania School of Medicine, 3400 Civic Center Blvd., Philadelphia, PA 19104-5158, USA.

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http://dx.doi.org/10.1182/blood-2011-12-398149DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3367878PMC
May 2012

Avoiding intuxication.

Blood 2012 Apr;119(16):3648-9

NYPH-Weill Medical College of Cornell University, USA.

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http://dx.doi.org/10.1182/blood-2012-02-406736DOI Listing
April 2012

How I treat heparin-induced thrombocytopenia.

Blood 2012 Mar 13;119(10):2209-18. Epub 2012 Jan 13.

Departments of Medicine, University of Pennsylvania, Philadelphia, USA.

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http://dx.doi.org/10.1182/blood-2011-11-376293DOI Listing
March 2012

RBC-coupled tPA Prevents Whereas tPA Aggravates JNK MAPK-Mediated Impairment of ATP- and Ca-Sensitive K Channel-Mediated Cerebrovasodilation After Cerebral Photothrombosis.

Transl Stroke Res 2012 Mar;3(1):114-21

Departments of Anesthesiology and Critical Care, University of Pennsylvania, 3620 Hamilton Walk, JM3, Philadelphia, PA 19104, USA. Pharmacology, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1007/s12975-011-0105-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3619434PMC
March 2012

Clinical trial opportunities in hemostasis and thrombosis: NHBLI State-of-the-Science symposium.

Am J Hematol 2012 Feb 25;87(2):235-8. Epub 2011 Nov 25.

Department of Pathology and Laboratory Medicine and Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1002/ajh.22225DOI Listing
February 2012

Urokinase plasminogen activator regulates pulmonary arterial contractility and vascular permeability in mice.

Am J Respir Cell Mol Biol 2011 Nov 26;45(5):1015-21. Epub 2011 May 26.

Department of Pathology, Laboratory Medicine, University of Pennsylvania, Philadelphia, 19104, USA.

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http://dx.doi.org/10.1165/rcmb.2010-0302OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3262683PMC
November 2011

tPA regulates pulmonary vascular activity through NMDA receptors.

Am J Physiol Lung Cell Mol Physiol 2011 Sep 13;301(3):L307-14. Epub 2011 May 13.

Dept. of Pathology and Laboratory Medicine, Univ. of Pennsylvania, 513A Stellar-Chance, 422 Curie Blvd., Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1152/ajplung.00429.2010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3174743PMC
September 2011

tPA contributes to impaired NMDA cerebrovasodilation after traumatic brain injury through activation of JNK MAPK.

Neurol Res 2011 Sep;33(7):726-33

Department of Anesthesiology and Critical Care, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1179/016164110X12807570509853DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3523283PMC
September 2011

Flow-dependent channel formation in clots by an erythrocyte-bound fibrinolytic agent.

Blood 2011 May 9;117(18):4964-7. Epub 2011 Mar 9.

Department of Cell & Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.

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http://dx.doi.org/10.1182/blood-2010-10-310409DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3100703PMC
May 2011

Immune thrombocytopenia.

Hematology Am Soc Hematol Educ Program 2010 ;2010:377-84

Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1182/asheducation-2010.1.377DOI Listing
April 2011

Evidence-based mini-review: Is indium-labeled autologous platelet scanning predictive of response to splenectomy in patients with chronic immune thrombocytopenia?

Hematology Am Soc Hematol Educ Program 2010 ;2010:385-6

Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1182/asheducation-2010.1.385DOI Listing
April 2011

tPA contributes to impairment of ATP and Ca sensitive K channel mediated cerebrovasodilation after hypoxia/ischemia through upregulation of ERK MAPK.

Brain Res 2011 Feb 20;1376:88-93. Epub 2010 Dec 20.

Department of Anesthesiology and Critical Care, University of Pennsylvania, Philadelphia, PA l9l04, USA.

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http://dx.doi.org/10.1016/j.brainres.2010.12.052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3038175PMC
February 2011

Regulation of airway contractility by plasminogen activators through N-methyl-D-aspartate receptor-1.

Am J Respir Cell Mol Biol 2010 Dec 22;43(6):703-11. Epub 2010 Jan 22.

Department of Pathology and Laboratory Medicine, University of Pennsylvania, 513A Stellar-Chance, 422 Curie Boulevard, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1165/rcmb.2009-0257OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2993090PMC
December 2010

Urokinase-type plasminogen activator inhibits efferocytosis of neutrophils.

Am J Respir Crit Care Med 2010 Dec 23;182(12):1516-23. Epub 2010 Jul 23.

Department of Medicine, University of Alabama at Birmingham, 35294, USA.

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http://dx.doi.org/10.1164/rccm.201003-0452OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3029937PMC
December 2010

Novel plasminogen activator inhibitor-1-derived peptide protects against impairment of cerebrovasodilation after photothrombosis through inhibition of JNK MAPK.

Am J Physiol Regul Integr Comp Physiol 2010 Aug 10;299(2):R480-5. Epub 2010 Jun 10.

Dept. of Anesthesiology and Critical Care, 3620 Hamilton Walk, JM3, Univ. of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1152/ajpregu.00256.2010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2928614PMC
August 2010

Future research in ITP: an ICIS consensus.

Ann Hematol 2010 Jul 23;89 Suppl 1:19-23. Epub 2010 Mar 23.

Department of Pathology, Stanford University School of Medicine, L235, Stanford, CA, 94305, USA,

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http://dx.doi.org/10.1007/s00277-010-0917-1DOI Listing
July 2010

PAI-1-derived peptide EEIIMD prevents impairment of cerebrovasodilation by augmenting p38 MAPK upregulation after cerebral hypoxia/ischemia.

Am J Physiol Heart Circ Physiol 2010 Jul 30;299(1):H76-80. Epub 2010 Apr 30.

Department of Anesthesiology and Critical Care, University of Pennsylvania, 3620 Hamilton Walk, Philadelphia, PA 19104, USA.

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http://www.physiology.org/doi/10.1152/ajpheart.00185.2010
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http://dx.doi.org/10.1152/ajpheart.00185.2010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2904139PMC
July 2010

Blood-brain barrier permeability and tPA-mediated neurotoxicity.

Neuropharmacology 2010 Jun 6;58(7):972-80. Epub 2010 Jan 6.

Department of Clinical Biochemistry, Hebrew University - Hadassah Medical Center, Jerusalem, Israel.

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http://dx.doi.org/10.1016/j.neuropharm.2009.12.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4423729PMC
June 2010

Induction of tissue factor by urokinase in lung epithelial cells and in the lungs.

Am J Respir Crit Care Med 2010 Jun 1;181(12):1355-66. Epub 2010 Mar 1.

Department of Specialty Care Services, The Texas Lung Injury Institute, University of Texas Health Center at Tyler, 11937 US Highway 271, Tyler, TX 75708, USA.

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http://www.atsjournals.org/doi/abs/10.1164/rccm.200901-0015O
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http://dx.doi.org/10.1164/rccm.200901-0015OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2894411PMC
June 2010

Sustained thromboprophylaxis mediated by an RBC-targeted pro-urokinase zymogen activated at the site of clot formation.

Blood 2010 Jun 21;115(25):5241-8. Epub 2010 Apr 21.

Program in Targeted Therapeutics, Institute for Translational Medicine and Therapeutics and Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia 19104-6068, USA.

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http://dx.doi.org/10.1182/blood-2010-01-261610DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2892950PMC
June 2010

Targeting of a mutant plasminogen activator to circulating red blood cells for prophylactic fibrinolysis.

J Pharmacol Exp Ther 2010 Mar 1;332(3):1022-31. Epub 2009 Dec 1.

IFEM, University of Pennsylvania School of Medicine, One John Morgan Building, 3620 Hamilton Walk, Philadelphia, PA 19104-6068, USA.

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http://dx.doi.org/10.1124/jpet.109.159194DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2835436PMC
March 2010